[
    {
        "uniprot_canonical_ac": "P34130-1",
        "uniprot_id": "NTF4_HUMAN",
        "mass": 22427.0,
        "length": 210,
        "protein_name": "Neurotrophin-4",
        "gene_name": "NTF4",
        "organism": "Human",
        "refseq_name": "neurotrophin-4 preproprotein",
        "refseq_ac": "NP_006170",
        "gene_names_uniprotkb": "NTF4; NTF5",
        "gene_names_refseq": "GLC10; GLC1O; NT-4/5; NT-4; NT-5; NT4; NT5; NTF4; NTF5",
        "protein_names_uniprotkb": "Neurotrophin-4; NT-4; NT-5; Neurotrophin-5; Neutrophic factor 4",
        "protein_names_refseq": "neurotrophic factor 4; neurotrophic factor 5; neurotrophin 5 (neurotrophin 4/5); neurotrophin-4 preproprotein; neurotrophin-5; neutrophic factor 4",
        "tax_id": 9606,
        "disease": "open-angle glaucoma (Disease Ontology:DOID:1067)",
        "pathway": " (hsa:4909);  (R-HSA-1257604);  (R-HSA-2219530);  (R-HSA-6811558);  (R-HSA-9026357);  (R-HSA-9026519);  (R-HSA-9026527);  (R-HSA-9028335);  (R-HSA-9028731)",
        "pathway_count": 9,
        "publication_count": 63,
        "publication_id_list": "10191262;10196222;10579907;10631974;11147812;11237011;11803464;12167717;12767043;1313578;1325671;15718470;15834429;16339315;16456541;16647110;17200115;1742028;17626883;18079394;18317450;18594509;18606717;18754654;18755892;18829560;18925875;19185485;19411071;19576174;19644473;19765683;19805105;19962665;20215012;20231295;20338997;20522708;20713702;21188471;21317208;21368164;21478295;21668414;21827948;21976531;21984976;22120714;22188813;22588880;22802530;24470253;33141586;34076998;34087483;34445512;34481496;7637810;7744773;8645157;8657148;9736715;9895304",
        "class_list": "",
        "function": "NTF4 stimulates the progression of gastric cancer via regulating FOXL1., [RefSeq, PubMed]; Single-cell transcriptome and cell-specific network analysis reveal the reparative effect of neurotrophin-4 in preantral follicles grown in vitro. Publication Status: Online-Only, [RefSeq, PubMed]; Target-derived survival factor for peripheral sensory sympathetic neurons (PubMed:1742028). May promote ameloblast differentiation and subsequent reduction in proliferation of ameloblasts (By similarity)., [UniProtKB, UniProtKB, PubMed]; The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3  prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6FH56",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0008021 synaptic vesicle",
        "go_biological_process": "GO:0007402 ganglion mother cell fate determination;GO:0008052 sensory organ boundary specification;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008344 adult locomotory behavior;GO:0008544 epidermis development",
        "synthesized_glycan_count": 0,
        "hit_score": 6.4,
        "record_id": "P34130-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96PB7-1",
        "uniprot_id": "NOE3_HUMAN",
        "mass": 54930.0,
        "length": 478,
        "protein_name": "Noelin-3",
        "gene_name": "OLFM3",
        "organism": "Human",
        "refseq_name": "noelin-3 isoform 1 precursor",
        "refseq_ac": "NP_001275750",
        "gene_names_uniprotkb": "OLFM3; NOE3; PRO4399",
        "gene_names_refseq": "NOE3; NOELIN3; OLFM3; OPTIMEDIN",
        "protein_names_uniprotkb": "Noelin-3; Olfactomedin-3; Optimedin",
        "protein_names_refseq": "noelin-3 isoform 1 precursor; noelin-3; olfactomedin related ER localized protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:118427)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "12019210;12975309;15123989;16115881;18519826;21228389;22281030;29557506;35051231;38253038",
        "class_list": "",
        "function": "Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Pax6 regulation of Optimedin in the eye and brain may directly affect multiple developmental processes, including cell migration and axon growth, [RefSeq, PubMed]; This is the first instance of OLFM3 being linked with anoikis resistance in a human cancer cell line, [RefSeq, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T3V6;Q6IMI7;Q6IMI8;Q6IMI9;Q6IMJ1;Q8TBG1;Q96PB2;Q96PB3;Q96PB4;Q96PB5;Q96PB6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0045202 synapse;GO:0032281 AMPA glutamate receptor complex",
        "go_biological_process": "GO:0007165 signal transduction;GO:0042462 eye photoreceptor cell development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q96PB7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43865-1",
        "uniprot_id": "SAHH2_HUMAN",
        "mass": 58951.0,
        "length": 530,
        "protein_name": "S-adenosylhomocysteine hydrolase-like protein 1",
        "gene_name": "AHCYL1",
        "organism": "Human",
        "refseq_name": "S-adenosylhomocysteine hydrolase-like protein 1 isoform b",
        "refseq_ac": "NP_001229602",
        "gene_names_uniprotkb": "AHCYL1; DCAL; IRBIT; XPVKONA",
        "gene_names_refseq": "AHCYL1; DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA",
        "protein_names_uniprotkb": "S-adenosylhomocysteine hydrolase-like protein 1; AdoHcyase 2; DC-expressed AHCY-like molecule; IP(3)Rs binding protein released with IP(3); IRBIT; Putative adenosylhomocysteinase 2; S-adenosyl-L-homocysteine hydrolase 2",
        "protein_names_refseq": "DC-expressed AHCY-like molecule; IP(3)Rs binding protein released with IP(3); S-adenosyl homocysteine hydrolase homolog; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase-like protein 1 isoform b; S-adenosylhomocysteine hydrolase-like protein 1; adoHcyase 2; dendritic cell expressed AHCY-like protein; epididymis secretory sperm binding protein; inositol 1,4,5-trisphosphate receptor-binding protein; protein phosphatase 1, regulatory subunit 78; putative adenosylhomocysteinase 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10768);  (R-HSA-111996);  (R-HSA-112043);  (R-HSA-1489509);  (R-HSA-2029485);  (R-HSA-2871809);  (R-HSA-422356);  (R-HSA-5218921);  (R-HSA-5578775);  (R-HSA-5607763);  (R-HSA-9664323);  (R-HSA-983695)",
        "pathway_count": 12,
        "publication_count": 377,
        "publication_id_list": "10.1101/2023.09.13.557529;10051622;10194514;10206966;10220561;10224668;10342826;10421574;10424882;10432293;10498607;10526167;10556826;10579907;10648173;10706702;10770799;10773014;10802064;1081164;10860980;10861086;10866047;10868950;10880360;10913253;10983984;11015619;11030334;11042164;11062458;11071869;11078440;11078469;11118617;11226282;11264248;11387210;11395409;11425868;11449366;11577798;11600407;11606584;11716850;11749377;11780755;11815450;11815460;11815462;11815463;11873862;11901194;11904675;11909947;12117970;12119109;12181444;12196472;12391145;12403834;12417718;12453414;12456653;12475777;12573241;12660731;12684222;12764427;12776187;12832055;12840507;12869549;12878157;12887316;12953268;12975316;1309948;1322796;13459201;1372004;1372019;1374290;1375264;1376928;14514350;14532121;15000528;15161916;15174025;15187135;15260953;15294978;15305887;15504896;1550550;15509800;15536084;15572341;15585596;15598648;15678092;15754088;15809313;15879121;15879134;15951569;1599430;16332676;16443778;16497229;16513675;16556766;16678913;16714477;16754674;16769890;16793548;16849466;16861033;16868246;16906149;16921024;1693919;17016520;17021801;1702903;1705565;17224452;17259518;17357072;17380317;17452328;17486119;17502104;17590538;17635105;17660294;17900700;17919183;18006696;18025150;18052078;18070890;18162464;18187424;18296442;18326500;18346985;18420269;18596693;18596924;18669648;18818202;18829453;18843204;18995841;19206206;19220705;19224921;19249086;19278978;19372136;19587354;19751721;19901323;20068231;20086079;2011584;20192804;20388710;20584908;20807769;21037092;21108950;21406692;21408196;21469132;21822214;22180443;22210847;2226863;22424782;22427649;22707725;22972900;2303036;2304550;23186163;23362265;23481700;23549614;23610579;23675550;23992284;2430951;24366607;24397554;24714562;24715725;2477373;25237103;25576301;2559024;25645385;25880248;25994790;26154972;26375851;26517901;26728094;26768311;26811146;26992070;27279487;27600516;27846572;27862975;27920218;27995898;28218747;28228285;2838329;28467828;28514659;28645727;28647132;28832583;28834231;28904123;29108130;29242379;29314611;29371260;29393594;29437277;29493099;29508533;2953725;29557506;29632711;29769354;29786170;29789417;30315122;30410026;30429286;30484775;30524438;30779550;30833945;31067468;31092671;31154438;31217245;31222486;31530632;31799605;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33717175;33912179;33936100;33968037;33981976;33993848;34087483;34171305;34185709;34211107;34229054;34357683;34405274;34509645;34725712;34932366;3500860;35051231;35138101;35154160;3517644;35218773;35251023;35318648;35580925;36010968;36215666;36241641;36284347;37938771;38294692;38665916;39154900;3923453;4589993;6019353;6328127;6335036;6424440;6435940;7517665;7518558;7522622;7524079;7528218;7530449;7538118;7589840;7592958;7593639;7641683;7687428;7687539;7688784;7691807;7702581;7782076;7927516;7929371;7929812;8027028;803528;8163536;8226994;8228618;8306975;8340414;8457197;8629002;8630736;8631904;8657103;8675920;8798450;8799126;8862523;8918259;8947047;8987985;8997178;9000504;9042338;9050880;9162098;9218480;9235916;9314552;9326643;9341187;9346285;9350615;9382888;9697839;9705962;9726229;9739505;9751501;9857068;9889098;9914469;9973503",
        "class_list": "",
        "function": "Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (PubMed:27995898). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). Functions as a SAH (S-adenosyl-L-homocysteine) sensor that inhibits autophagy through an MTORC1-independent mechanism. Upon SAH binding, interacts with the catalytic domain of PIK3C3, inhibiting its lipid kinase activity and reducing production of phosphatidylinositol-3-phosphate (PtdIns3P), thereby blocking autophagosome formation (PubMed:33993848)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; NRAS Mutant Dictates AHCYL1-Governed ER Calcium Homeostasis for Melanoma Tumor Growth., [RefSeq, PubMed]; The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]., [RefSeq]; The role of S-adenosylhomocysteine hydrolase-like 1 in cancer. Review article, [RefSeq, PubMed]; Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 20,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E168;Q2TAJ6;Q502W8;Q5VSM0;Q6P171;Q96PK4;Q9UG84",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0030234 enzyme regulator activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0042045 epithelial fluid transport;GO:0051592 response to calcium ion;GO:0006915 apoptotic process;GO:0038166 angiotensin-activated signaling pathway;GO:0006730 one-carbon metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 38.2,
        "record_id": "O43865-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92622-1",
        "uniprot_id": "RUBIC_HUMAN",
        "mass": 108622.0,
        "length": 972,
        "protein_name": "Run domain Beclin-1-interacting and cysteine-rich domain-containing protein",
        "gene_name": "RUBCN",
        "organism": "Human",
        "refseq_name": "run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform 1",
        "refseq_ac": "NP_001139114",
        "gene_names_uniprotkb": "RUBCN; KIAA0226",
        "gene_names_refseq": "KIAA0226; RUBCN; RUBICON; SCAR15",
        "protein_names_uniprotkb": "Run domain Beclin-1-interacting and cysteine-rich domain-containing protein; Baron; Beclin-1 associated RUN domain containing protein; Rubicon",
        "protein_names_refseq": "RUN and cysteine rich domain containing beclin 1 interacting protein; RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein; baron; beclin-1 associated RUN domain containing protein; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform 1; rundataxin",
        "tax_id": 9606,
        "disease": "autosomal recessive spinocerebellar ataxia 15 (Disease Ontology:DOID:0080057)",
        "pathway": " (hsa:9711)",
        "pathway_count": 1,
        "publication_count": 52,
        "publication_id_list": "11237011;18691976;19270696;19369195;19690332;20826435;20943950;20974968;21062745;22423966;22423967;23186163;23481700;23728897;26154972;26992070;27846572;27862975;28228285;28832583;28834231;28904123;29242379;29331515;29557506;29632046;29769354;30315122;30410026;31154438;31217245;31752345;31844290;32157095;32350084;32488085;32502341;32938616;33141586;33717175;33912179;33936100;33968037;33981976;34171305;35051231;35580925;35740989;36010968;36241641;37938771;38728007",
        "class_list": "",
        "function": "A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy., [RefSeq, PubMed]; Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745)., [UniProtKB, PubMed, PubMed]; Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967)., [UniProtKB, PubMed, PubMed]; Neuronal Rubicon Represses Extracellular APP/Amyloid beta Deposition in Alzheimer's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]., [RefSeq]; This study demonistrated that KIAA0226 mutation impairs Rubicon endosomal localization, [RefSeq, PubMed]; Two Beclin 1 associated proteins, Atg14L and Rubicon, were identified., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 16,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96CK5",
        "ec_number_list": "",
        "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity",
        "go_cellular_component": "GO:0005769 early endosome;GO:0005764 lysosome;GO:0005770 late endosome",
        "go_biological_process": "GO:0071985 multivesicular body sorting pathway;GO:1901097 negative regulation of autophagosome maturation;GO:0045806 negative regulation of endocytosis;GO:0006909 phagocytosis;GO:0006914 autophagy",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q92622-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96G01-1",
        "uniprot_id": "BICD1_HUMAN",
        "mass": 110750.0,
        "length": 975,
        "protein_name": "Protein bicaudal D homolog 1",
        "gene_name": "BICD1",
        "organism": "Human",
        "refseq_name": "protein bicaudal D homolog 1 isoform 2",
        "refseq_ac": "NP_001003398",
        "gene_names_uniprotkb": "BICD1",
        "gene_names_refseq": "BICD1; BICD; bic-D 1",
        "protein_names_uniprotkb": "Protein bicaudal D homolog 1; Bic-D 1",
        "protein_names_refseq": "bicaudal D homolog 1; cytoskeleton-like bicaudal D protein homolog 1; protein bicaudal D homolog 1 isoform 2",
        "tax_id": 9606,
        "disease": "spinal muscular atrophy with lower extremity predominant 2A (Disease Ontology:DOID:0070349)",
        "pathway": " (hsa:636);  (R-HSA-6811436)",
        "pathway_count": 2,
        "publication_count": 89,
        "publication_id_list": "10359595;10559986;10562278;11080672;11237011;11483508;12401177;12432908;12447383;12925777;15483056;15914536;16207721;16314391;17139249;17488286;17707369;17827179;18641641;18664496;19635840;19753100;20058876;20089649;20420828;21173190;22130221;22424782;22562055;23333653;23481700;23783758;24366607;24715725;24891604;25233431;25453831;25892735;26154972;26811146;26992070;27920218;28228285;28832583;28834231;28904123;29242379;29632046;29769354;29786170;30410026;30429286;30484775;31217245;31844290;31846791;32088084;32157095;32357974;32387766;32502341;32897882;32938616;32983136;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;34211107;34357683;34509645;35051231;35318648;35561310;35580925;36010968;36215666;36241641;37240244;37938771;9030515;9050864;9367685;9671731;9733780",
        "class_list": "",
        "function": "BICD1 functions as a prognostic biomarker and promotes hepatocellular carcinoma progression., [RefSeq, PubMed]; BICD1 genes may contribute to the decrease in forced vital capacity levels by interacting with PM10 exposure, [RefSeq, PubMed]; Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex., [UniProtKB]; This gene encodes an adaptor protein that belongs to the bicaudal D family of dynein cargo adaptors. The encoded protein acts as an intracellular cargo transport cofactor that regulates the microtubule-based loading of cargo onto the dynein motor complex. It also controls dynein motor activity and coordination. It has a domain architecture consisting of coiled-coil domains at the N- and C-termini that are highly conserved in other family members. Naturally occurring mutations in this gene are associated with short telomere length and emphysema. [provided by RefSeq, Aug 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2C3;F8W113;O43892;O43893",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0019901 protein kinase binding;GO:0008093 cytoskeletal anchor activity;GO:0031267 small GTPase binding;GO:0070840 dynein complex binding",
        "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0045054 constitutive secretory pathway;GO:0006396 RNA processing;GO:1904781 positive regulation of protein localization to centrosome;GO:0048260 positive regulation of receptor-mediated endocytosis;GO:0019068 virion assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "Q96G01-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P08236-1",
        "uniprot_id": "BGLR_HUMAN",
        "mass": 74732.0,
        "length": 651,
        "protein_name": "Beta-glucuronidase",
        "gene_name": "GUSB",
        "organism": "Human",
        "refseq_name": "beta-glucuronidase isoform 1 precursor",
        "refseq_ac": "NP_000172",
        "gene_names_uniprotkb": "GUSB",
        "gene_names_refseq": "BG; GUSB; MPS7",
        "protein_names_uniprotkb": "Beta-glucuronidase; 3.2.1.31; Beta-G1",
        "protein_names_refseq": "beta-D-glucuronidase; beta-G1; beta-glucuronidase isoform 1 precursor; beta-glucuronidase",
        "tax_id": 9606,
        "disease": "mucopolysaccharidosis (Disease Ontology:DOID:12798); mucopolysaccharidosis type VII (Disease Ontology:DOID:12803); peritonitis (Disease Ontology:DOID:8283)",
        "pathway": " (hsa:2990);  (R-HSA-2024101);  (R-HSA-2160916);  (R-HSA-2206292);  (R-HSA-6798695);  (R-HSA-9953080)",
        "pathway_count": 6,
        "publication_count": 152,
        "publication_id_list": "37639587;10.1007/s00018-021-03863-1;10.1101/2023.09.13.557529;10339581;11226217;11237011;11350981;11568288;12403825;12522561;12754519;12859417;12888274;1311180;144057;14514708;15035633;15090545;15503855;15510212;15647514;16104017;16335952;1702266;17050540;1833732;1907800;19159218;1916806;19224584;1928092;1946389;19889881;2122463;22661428;23090970;23481700;23509262;23650620;24190977;24260279;24366607;25418920;25645385;25880248;26154972;26811146;26992070;27846572;27862975;27920218;28218747;28228285;28514659;28649982;28734840;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29508533;29557506;29632046;29632711;2971395;29741879;29786170;29885630;30059200;30192525;30315122;30410026;30429286;30444036;30779550;30833945;31154438;31217245;3134052;31530632;31611695;31844290;31937595;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;3355537;33592498;33691108;33717175;33912179;33936100;33968037;34089345;34171305;34211107;34357683;34509645;34561969;3468507;35051231;35251023;35254053;35318648;35561310;35580925;35812439;36010968;36215666;36241641;36284347;36473630;37074911;37938771;3924735;5822067;6811712;738706;7573038;7628016;7633414;7680524;8089138;8111412;8111413;8213840;8282124;8505339;8599764;8644704;8692836;8707294;8901634;9099834;9223416;9490302;9521684;9712871",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "Macrophages and derived-TNF-alpha promote lipopolysaccharide-induced upregulation of endogenous beta-glucuronidase in the epithelial cells of the bile duct: A possible facilitator of hepatolithiasis formation., [RefSeq, PubMed]; Over-Expression of GUSB Leads to Primary Resistance of Anti-PD1 Therapy in Hepatocellular Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Plays an important role in the degradation of dermatan and keratan sulfates., [UniProtKB]; Study summarized information on the 49 unique, disease-causing mutations determined so far in the GUS gene. Review article, [RefSeq, PubMed]; The beta-d-galactosidase, beta-d-glucuronidase and alpha-l-fucosidase activities in serums from hemolyzed blood, were determined., [RefSeq, PubMed]; This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]., [RefSeq]; We produced GUS from a CHO cell line grown in suspension in a 15 L perfused bioreactor and developed a three step purification procedure that yields approximately 99% pure enzyme with a recovery of more than 40%., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 3,
        "mined_n_glycosites": 3,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 8,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 860,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 45,
        "disease_count": 3,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E1F6;E9PCV0;Q549U0;Q96CL9",
        "ec_number_list": "3.4.19.12;3.6.4.13;4.6.1.19;3.2.1.24;1.1.1.42;1.6.2.2;2.4.2.1;3.4.21.46;1.16.3.1;1.11.1.6;3.2.1.51;4.1.2.13;3.5.3.1;1.11.2.2;3.2.1.-;3.2.1.22;2.4.1.1;5.3.1.9;5.1.3.-;3.4.23.5;3.4.22.52;3.4.21.4;3.2.1.52;3.4.22.1;3.6.4.10;3.2.1.31;3.4.21.37;3.4.21.20;2.5.1.18;1.13.11.-;1.13.11.34;3.3.2.6;3.4.11.4;4.6.1.18;3.4.16.5;3.4.16.-;1.1.1.205;3.1.27.-;4.2.99.18;5.6.2.4;3.6.5.-;4.2.1.24;3.4.19.1;5.3.2.1;5.3.3.12;2.7.10.2;2.7.11.1;2.7.1.40;3.4.24.35;3.1.6.8;3.1.6.14;3.1.6.12;3.2.1.23;2.7.1.11;5.4.2.11;5.4.2.4;3.5.1.26;2.7.4.6;2.7.13.3;3.4.21.76;3.4.22.27;2.7.11.24;1.11.1.27;3.1.1.4;2.3.1.23;3.5.4.5;3.1.6.4;5.4.2.2;2.4.1.186;3.6.1.-;2.7.1.1;2.7.1.-;2.3.3.8;3.4.14.1;3.6.4.6;3.2.1.17;5.2.1.8;3.1.1.47;3.1.1.-;3.5.4.6;2.7.11.13;1.11.1.24;3.5.1.23;3.5.1.-;3.5.1.109;2.7.11.22;2.7.11.23;2.3.2.5;6.3.4.21;2.3.2.26;1.8.4.-;5.3.4.1;3.6.1.6;3.4.19.9;5.4.2.7;3.4.25.1;1.6.5.5;3.1.3.16;5.3.99.3;3.5.4.4;2.3.2.27;3.4.18.1;3.4.14.2;3.5.3.15;4.1.2.4",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019904 protein domain specific binding;GO:0030246 carbohydrate binding;GO:0004566 beta-glucuronidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006027 glycosaminoglycan catabolic process;GO:0030207 chondroitin sulfate proteoglycan catabolic process;GO:0030200 heparan sulfate proteoglycan catabolic process;GO:0030214 hyaluronan catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 20.5,
        "record_id": "P08236-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z4V0-1",
        "uniprot_id": "ZN438_HUMAN",
        "mass": 91836.0,
        "length": 828,
        "protein_name": "Zinc finger protein 438",
        "gene_name": "ZNF438",
        "organism": "Human",
        "refseq_name": "zinc finger protein 438 isoform a",
        "refseq_ac": "NP_001137238",
        "gene_names_uniprotkb": "ZNF438",
        "gene_names_refseq": "ZNF438; bA330O11.1",
        "protein_names_uniprotkb": "Zinc finger protein 438",
        "protein_names_refseq": "zinc finger protein 438 isoform a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:220929)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "11237011;16385451;16959974;17669267;23481700;28832583;29242379;29557506;30379171;30429286;30484775;31844290;31848261;32157095;32387766;32488085;32938616;33298915;34171305;34509645;34561969;35051231;36215666;37217939",
        "class_list": "",
        "function": "Isoform 1 acts as a transcriptional repressor., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The transcriptional activity of ZNF438 was studied by transfecting recombinant pM-ZNF438 into mammalian cells. The subsequent analysis based on the duel luciferase assay system showed that ZNF438 was a transcriptional repressor., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A3J4;A8K9L5;Q5T426;Q658Q4;Q6ZN65",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q7Z4V0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15560-1",
        "uniprot_id": "TCEA2_HUMAN",
        "mass": 33601.0,
        "length": 299,
        "protein_name": "Transcription elongation factor A protein 2",
        "gene_name": "TCEA2",
        "organism": "Human",
        "refseq_name": "transcription elongation factor A protein 2 isoform a",
        "refseq_ac": "NP_003186",
        "gene_names_uniprotkb": "TCEA2",
        "gene_names_refseq": "TCEA2; TFIIS",
        "protein_names_uniprotkb": "Transcription elongation factor A protein 2; Testis-specific S-II; Transcription elongation factor S-II protein 2; Transcription elongation factor TFIIS.l",
        "protein_names_refseq": "testis-specific S-II; transcription elongation factor A (SII), 2; transcription elongation factor A protein 2 isoform a; transcription elongation factor A protein 2; transcription elongation factor S-II protein 2; transcription elongation factor TFIIS.1; transcription elongation factor TFIIS.l",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6919)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "11237011;12034815;12943681;18655026;20068231;23301498;23481700;27846572;27920218;28063628;28834231;29242379;29393594;29557506;29632046;30779550;31154438;31217245;31530632;31844290;31998317;32157095;32387766;32488085;32502341;32938616;33141586;33298915;33968037;34087483;35051231;41062692;8566795;9441762",
        "class_list": "",
        "function": "Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KNM1;Q8TD37;Q8TD38",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003711 transcription elongation factor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex",
        "go_biological_process": "GO:0006368 transcription elongation by RNA polymerase II;GO:0032784 regulation of DNA-templated transcription elongation;GO:0006354 DNA-templated transcription elongation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q15560-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A2AJT9-1",
        "uniprot_id": "BCLA3_HUMAN",
        "mass": 83871.0,
        "length": 711,
        "protein_name": "BCLAF1 and THRAP3 family member 3",
        "gene_name": "BCLAF3",
        "organism": "Human",
        "refseq_name": "BCLAF1 and THRAP3 family member 3 isoform 1",
        "refseq_ac": "NP_938020",
        "gene_names_uniprotkb": "BCLAF3; CXorf23",
        "gene_names_refseq": "BCLAF3; CXorf23; TOBF1",
        "protein_names_uniprotkb": "BCLAF1 and THRAP3 family member 3; TOBF1; Transient octamer binding factor 1",
        "protein_names_refseq": "BCLAF1 and THRAP3 family member 3 isoform 1; transient octamer binding factor 1; uncharacterized protein CXorf23",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:256643)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "11237011;18669648;21406692;23186163;24715725;25576301;29557506;30429286;31844290;32157095;32938616;32983136;33592498;33912179;35051231;36241641;36284347",
        "class_list": "",
        "function": "Component of the spliceosome complex, important for maintaining embryonic stem cell (ESC) fate. May also be involved in the negative regulation of Wnt-driven stem cell-dependent epithelial renewal in the gastric mucosa., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A4E8;Q5VSM7;Q5VSN1;Q6ZS60;Q8N1W7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003712 transcription coregulator activity",
        "go_cellular_component": "GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0016592 mediator complex",
        "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000380 alternative mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "A2AJT9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TCE9-1",
        "uniprot_id": "PPL13_HUMAN",
        "mass": 16094.0,
        "length": 139,
        "protein_name": "Placental protein 13-like",
        "gene_name": "LGALS14",
        "organism": "Human",
        "refseq_name": "placental protein 13-like isoform 1",
        "refseq_ac": "NP_064514",
        "gene_names_uniprotkb": "LGALS14; PPL13",
        "gene_names_refseq": "CLC2; LGALS14; PPL13",
        "protein_names_uniprotkb": "Placental protein 13-like; CLC2; Charcot-Leyden crystal protein 2; Gal-14; Galectin-14",
        "protein_names_refseq": "Charcot-Leyden crystal protein 2; gal-14; lectin, galactoside-binding, soluble, 14; placental protein 13-like isoform 1; placental protein 13-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56891)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "11237011;11997112;16831268;17975119;19023099;19497882;25418920;25892735;27920218;28832583;29242379;29632046;31844290;32525264;32983136",
        "class_list": "glycogene",
        "function": "Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis., [UniProtKB, PubMed]; CIC-2 siRNA could inhibit the cell proliferation of a human glioma cell line U-87., [RefSeq, PubMed]; Cloning and expression in placenta - base sequence and amino acid sequences are given, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Structure-function studies of galectin-14, an important effector molecule in embryology., [RefSeq, PubMed]; This gene is predominantly expressed in placenta. The encoded protein belongs to the galectin (galaptin/S-lectin) family. The members of galectin family contain one or two carbohydrate recognition domains, which can bind beta-galactoside. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 195,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MPV8;B2R530;C5HZ19;Q7Z4X8;Q96KD4;Q96KD5;Q96KD6;Q9NR03",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030246 carbohydrate binding",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q8TCE9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z3K3-1",
        "uniprot_id": "POGZ_HUMAN",
        "mass": 155344.0,
        "length": 1410,
        "protein_name": "Pogo transposable element with ZNF domain",
        "gene_name": "POGZ",
        "organism": "Human",
        "refseq_name": "pogo transposable element with ZNF domain isoform 4",
        "refseq_ac": "NP_001181866",
        "gene_names_uniprotkb": "POGZ; KIAA0461; Nbla00003; SUHW5; ZNF280E; ZNF635",
        "gene_names_refseq": "MRD37; POGZ; WHSUS; ZNF280E; ZNF635m; ZNF635",
        "protein_names_uniprotkb": "Pogo transposable element with ZNF domain; Suppressor of hairy wing homolog 5; Zinc finger protein 280E; Zinc finger protein 635",
        "protein_names_refseq": "pogo transposable element with ZNF domain isoform 4; pogo transposable element with ZNF domain; putative protein product of Nbla00003; zinc finger protein 280E; zinc finger protein 635",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); White-Sutton syndrome (Disease Ontology:DOID:0070067); intellectual disability (Disease Ontology:DOID:1059)",
        "pathway": " (hsa:23126)",
        "pathway_count": 1,
        "publication_count": 133,
        "publication_id_list": "10.1101/2023.09.13.557529;10976766;11237011;12750860;12880961;15302935;17081983;18452278;18669648;19244240;19413330;19651622;19664995;19690332;19691289;20068230;20068231;20562864;20850016;21406692;22661428;23186163;23301498;23481700;24275569;24366607;24397554;24715725;25082813;25533962;25576301;25694107;25880248;26721387;26739615;26811146;26992070;27114449;27655845;27846572;27862975;27920218;28063628;28228285;28314751;28514659;28657654;28832583;28834231;28904123;29237092;29242379;29249144;29351928;29393594;29485866;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29997176;30059200;30315122;30379171;30429286;30484775;30524438;30620550;30779550;31092671;31154438;31492838;31530632;31637018;31844290;32119511;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32574038;32870666;32897882;32938616;32938750;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33691108;33912179;33968037;34019948;34087483;34185709;34509645;34561969;34725712;34846842;35051231;35052493;35132862;35254053;35289036;35318648;35367590;35513511;35580925;35705054;36010968;36241641;36658409;37340703;37541260;37938771;38350721;38665916;38838015;39302247;39531497;39534244;40136647;40307207;40596516",
        "class_list": "",
        "function": "Chromodomain on Y-like 2 (CDYL2) implicated in mitosis and genome stability regulation via interaction with CHAMP1 and POGZ. Publication Status: Online-Only, [RefSeq, PubMed]; Exploring the molecular pathways linking sleep phenotypes and POGZ-associated neurodevelopmental disorder. Publication Status: Online-Only, [RefSeq, PubMed]; Genotype-Phenotype Comparison in POGZ-Related Neurodevelopmental Disorders by Using Clinical Scoring. Publication Status: Online-Only, [RefSeq, PubMed]; LEDGF/p75 has a role in DDE domain protein function and interacts with the transposase-derived DDE domain of PogZ, [RefSeq, PubMed]; Loss of POGZ alters neural differentiation of human embryonic stem cells., [RefSeq, PubMed]; Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]., [RefSeq]; The results reveal POGZ as an essential protein that links HP1alpha dissociation with Aurora B kinase activation during mitosis., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 43,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 43,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 43,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 34,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 82,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 3,
        "glyco_site_count": 48,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DTP8;B4DYL9;B7ZBY5;E9PM80;O75049;Q3LIC4;Q5SZS1;Q5SZS2;Q5SZS3;Q5SZS4;Q8TDZ7;Q9Y4X7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0051382 kinetochore assembly;GO:0051301 cell division;GO:0006355 regulation of DNA-templated transcription;GO:0000724 double-strand break repair via homologous recombination;GO:0007064 mitotic sister chromatid cohesion",
        "synthesized_glycan_count": 0,
        "hit_score": 18.1,
        "record_id": "Q7Z3K3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NEB9-1",
        "uniprot_id": "PK3C3_HUMAN",
        "mass": 101549.0,
        "length": 887,
        "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3",
        "gene_name": "PIK3C3",
        "organism": "Human",
        "refseq_name": "phosphatidylinositol 3-kinase catalytic subunit type 3 isoform 1",
        "refseq_ac": "NP_002638",
        "gene_names_uniprotkb": "PIK3C3; VPS34",
        "gene_names_refseq": "PIK3C3; VPS34; Vps34; hVps34",
        "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase catalytic subunit type 3; 2.7.1.137; PI3-kinase type 3; PI3K type 3; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; PtdIns-3-kinase type 3; hVps34",
        "protein_names_refseq": "PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform 1; phosphatidylinositol 3-kinase p100 subunit; phosphoinositide-3-kinase, class 3; vacuolar protein sorting 34 homolog",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)",
        "pathway": " (hsa:5289);  (R-HSA-109704);  (R-HSA-1632852);  (R-HSA-1660514);  (R-HSA-1660516);  (R-HSA-1660517);  (R-HSA-168138);  (R-HSA-5668599);  (R-HSA-9679504);  (R-HSA-9694676);  (R-HSA-9705671);  (R-HSA-983170);  (R-HSA-9920951)",
        "pathway_count": 13,
        "publication_count": 305,
        "publication_id_list": "10064069;10072071;10101268;10400704;10419465;10455184;10559940;10567352;10600378;10764818;10766823;10777614;10805725;10806194;10825291;10982397;11027663;11090627;11096062;11145705;11160214;11163199;11237011;11279162;11302699;11514579;11706043;11716755;11733541;11825910;11923287;12019269;12056906;12270933;12324459;12436109;12436110;12645939;12660731;12692549;12716910;12759408;12847286;12890864;1381348;14527956;14530365;14617358;14659893;14660569;14681859;14718384;14722070;14751759;15187094;15207506;15208624;15286279;15331731;15591124;15716355;15824103;15927284;16329988;16417406;16465444;16473882;16507994;1655747;1660188;16636067;16762923;16778989;16787938;16847462;16963840;17056546;17088086;17316621;17555535;17556371;17583407;17618624;17651088;17656363;17878374;18321988;18347018;18439900;18524850;18691976;18820679;18950639;19050071;19119025;19193869;19211563;19211835;19261456;19270696;19322194;19342655;19361863;19369195;19372727;19413330;19426129;19438505;19575639;19590496;19664994;19668216;19805105;19851281;19855179;19898463;20059746;20208530;2038058;20513426;20605430;20643123;20713597;20813901;20921139;20956805;21050182;21081650;21177865;21205641;21239714;21258367;21383122;21460621;21604257;21799305;21819378;21827948;22095288;22170151;22493499;22682742;22808130;22941947;23186163;23202584;23289851;23685627;23727157;23818870;23875749;23878393;23884233;23954414;23980663;24342772;24397554;2450918;24582588;24747438;24855048;24954904;24973451;25135833;25484072;25568151;25576301;25645385;25869668;25877926;25892735;26496610;26811146;26992070;27108190;27452731;27558335;27600516;27846572;27920218;28218747;28228285;28299793;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30410026;31154438;31231549;31844290;31850239;32157095;32161166;32350084;32353859;32357974;32387766;32428392;32488085;32502341;32589897;32690950;32726803;32728199;32897882;32938616;32953130;32979938;32983136;33024073;33060197;33097660;33110251;33298915;33349665;33360543;33372174;33372854;33396605;33440148;33473107;33479219;33495715;33514628;33567255;33592498;33637724;33691108;33717175;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33912179;33963333;33968037;33981976;33989516;33990585;33993848;34021074;34054808;34084167;34110168;34166398;34171305;34239064;34290717;34320401;34341353;34357683;34375313;34400613;34439781;34452305;34471099;34502139;34509645;34597346;35051231;35102342;35580925;35643212;36010968;36241641;36284347;36310878;37051252;37267363;37938771;38609772;39173055;7543144;7608176;7628435;7642652;7761412;7876241;8089108;8342042;8634694;8999962;9148941;9295334;9405935;9516481;9605141;9804763;9878262",
        "class_list": "",
        "function": "(Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication., [UniProtKB, PubMed]; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435, PubMed:33993848). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Deregulated expression of autophagy genes; PIK3C3 and RAB7A in COVID-19 patients., [RefSeq, PubMed]; Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection. Publication Status: Online-Only, [RefSeq, PubMed]; ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "total_reported_o_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 17,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15134",
        "ec_number_list": "2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.1;2.7.10.1;2.7.11.31;3.1.3.48;2.7.11.26;3.6.5.2",
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0052742 phosphatidylinositol kinase activity;GO:0016301 kinase activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005777 peroxisome",
        "go_biological_process": "GO:0097352 autophagosome maturation;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0044829 host-mediated activation of viral genome replication;GO:0000045 autophagosome assembly;GO:0006897 endocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 30.6,
        "record_id": "Q8NEB9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P46527-1",
        "uniprot_id": "CDN1B_HUMAN",
        "mass": 22073.0,
        "length": 198,
        "protein_name": "Cyclin-dependent kinase inhibitor 1B",
        "gene_name": "CDKN1B",
        "organism": "Human",
        "refseq_name": "cyclin-dependent kinase inhibitor 1B",
        "refseq_ac": "NP_004055",
        "gene_names_uniprotkb": "CDKN1B; KIP1; p27",
        "gene_names_refseq": "CDKN1B; CDKN4; KIP1; MEN1B; MEN4; P27KIP1",
        "protein_names_uniprotkb": "Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1",
        "protein_names_refseq": "cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor 1B",
        "tax_id": 9606,
        "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); myelodysplastic syndrome (Disease Ontology:DOID:0050908); multiple endocrine neoplasia type 4 (Disease Ontology:DOID:0080137); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); sciatic neuropathy (Disease Ontology:DOID:11446); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); acute kidney failure (Disease Ontology:DOID:3021); multiple endocrine neoplasia (Disease Ontology:DOID:3125); pituitary adenoma (Disease Ontology:DOID:3829); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); infertility (Disease Ontology:DOID:5223); lung small cell carcinoma (Disease Ontology:DOID:5409); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); cataract (Disease Ontology:DOID:83); chronic myeloid leukemia (Disease Ontology:DOID:8552); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); senile cataract (Disease Ontology:DOID:9669); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:1027);  (R-HSA-187577);  (R-HSA-198323);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-5625900);  (R-HSA-5674400);  (R-HSA-6804116);  (R-HSA-69202);  (R-HSA-69205);  (R-HSA-69231);  (R-HSA-69563);  (R-HSA-69656);  (R-HSA-8849470);  (R-HSA-9607240);  (R-HSA-9617828);  (R-HSA-9634638);  (R-HSA-9661069)",
        "pathway_count": 18,
        "publication_count": 398,
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        "class_list": "",
        "function": "Data demonstrate that germ-line mutations in p27(Kip1) can predispose to the development of multiple endocrine tumors in both rats and humans. Erratum:[Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19213], [RefSeq, PubMed]; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The E3 ligase SMURF1 stabilizes p27 via UbcH7 catalyzed K29-linked ubiquitin chains to promote cell migration SMURF1-UbcH7 K29 ubiquitination of p27 and cell migration., [RefSeq, PubMed]; This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]., [RefSeq]; This study adds the CDKN1B gene to the short list of genes for which mutations that either create, delete, or severely modify their regulatory uORFs have been associated with human diseases, [RefSeq, PubMed]; UBE4B regulates p27 expression in A549 NSCLC cells through regulating the interaction of HuR and the p27 5' UTR., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 47,
        "reported_mutagensis": 17,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 30,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16307;Q5U0H2;Q9BUS6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome",
        "go_biological_process": "GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation;GO:0050680 negative regulation of epithelial cell proliferation;GO:0030308 negative regulation of cell growth;GO:0045930 negative regulation of mitotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 40.5,
        "record_id": "P46527-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13084-1",
        "uniprot_id": "RM28_HUMAN",
        "mass": 30157.0,
        "length": 256,
        "protein_name": "Large ribosomal subunit protein bL28m",
        "gene_name": "MRPL28",
        "organism": "Human",
        "refseq_name": "large ribosomal subunit protein bL28m",
        "refseq_ac": "NP_006419",
        "gene_names_uniprotkb": "MRPL28; MAAT1",
        "gene_names_refseq": "MAAT1; MRPL28; bL28m; p15",
        "protein_names_uniprotkb": "Large ribosomal subunit protein bL28m; 39S ribosomal protein L28, mitochondrial; L28mt; MRP-L28; Melanoma antigen p15; Melanoma-associated antigen recognized by T-lymphocytes",
        "protein_names_refseq": "39S ribosomal protein L28, mitochondrial; L28mt; MRP-L28; large ribosomal subunit protein bL28m; melanoma antigen p15; melanoma-associated antigen recognised by cytotoxic T lymphocytes; melanoma-associated antigen recognized by T-lymphocytes; mitochondrial large ribosomal subunit protein bL28m",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10573);  (R-HSA-5368286);  (R-HSA-5389840);  (R-HSA-5419276);  (R-HSA-9937383)",
        "pathway_count": 5,
        "publication_count": 62,
        "publication_id_list": "11237011;11551941;15358359;17803939;18429816;18782833;19524667;19716793;20186120;21907147;22172991;2250005;25233460;25278503;25418920;26154972;26929215;27029019;27846572;27893789;27920218;28228285;28510447;28832583;28834231;28892042;29242379;29393594;29557506;29632046;29786170;30315122;30833945;31154438;31844290;32265295;32357974;32387766;32488085;32502341;32938616;32983136;33091337;33141586;33243891;33392160;33691108;33878294;33936100;33968037;34171305;34561969;34932366;35177605;35580925;36010968;36241641;36302763;36596788;37141370;40914422;7751637",
        "class_list": "",
        "function": "Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "glyco_site_count": 0,
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        "secondary_ac_list": "B2RCM4;D3DU46;Q4TT39;Q96S26;Q9BQD8;Q9BR04",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome",
        "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome;GO:0005840 ribosome",
        "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q13084-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q05048-1",
        "uniprot_id": "CSTF1_HUMAN",
        "mass": 48358.0,
        "length": 431,
        "protein_name": "Cleavage stimulation factor subunit 1",
        "gene_name": "CSTF1",
        "organism": "Human",
        "refseq_name": "cleavage stimulation factor subunit 1",
        "refseq_ac": "NP_001028693",
        "gene_names_uniprotkb": "CSTF1",
        "gene_names_refseq": "CSTF1; CstF-50; CstFp50",
        "protein_names_uniprotkb": "Cleavage stimulation factor subunit 1; CF-1 50 kDa subunit; CSTF 50 kDa subunit; Cleavage stimulation factor 50 kDa subunit; CstF-50",
        "protein_names_refseq": "CF-1 50 kDa subunit; CSTF 50 kDa subunit; cleavage stimulation factor 50 kDa subunit; cleavage stimulation factor subunit 1; cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa; cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kD",
        "tax_id": 9606,
        "disease": "hereditary spastic paraplegia 5A (Disease Ontology:DOID:0110810); congenital bile acid synthesis defect 3 (Disease Ontology:DOID:0111070)",
        "pathway": " (hsa:1477);  (R-HSA-72187);  (R-HSA-73856);  (R-HSA-77595);  (R-HSA-9770562);  (R-HSA-9918481)",
        "pathway_count": 6,
        "publication_count": 148,
        "publication_id_list": "10.1101/2023.09.13.557529;10477523;10669729;11060040;11237011;11747608;11979277;12871933;1358884;14519844;14749727;14762106;15037765;15084397;15565158;15592455;15998806;17128255;17190602;17984224;18288197;18411249;18802091;18957205;18991276;19217410;19836239;20068231;20573985;20695905;20844015;21295486;21911577;21947206;21993680;22121020;22207203;22424782;22706990;22813749;22928037;23222130;23299939;23481700;23874216;24076191;24149845;24244187;24366607;24397554;24714562;24715725;25301780;25301781;25576301;25645385;25662211;25836925;26030138;26092250;26154972;26375851;26728094;26811146;26992070;27108190;27397612;27600516;27846572;27862975;27920218;28096519;28218747;28228285;28510447;28514659;28832583;28834231;28904123;28911096;29186539;29242379;29274231;29331515;29393594;29437277;29493099;29508533;29557506;29632711;29786170;29789417;29902443;30139799;30257008;30315122;30410026;30429286;30524438;30599162;31154438;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32816001;32897882;32938616;32983136;33123756;33141586;33177556;33214551;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;34019948;34087483;34171305;34211107;34229054;34357683;34509645;34932366;35051231;35177536;35215846;35318648;35561310;35580925;36010968;36241641;36284347;37938771;38665916;9659921",
        "class_list": "",
        "function": "One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (PubMed:10669729). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (PubMed:10669729)., [UniProtKB, PubMed]; This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5QPD8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005848 mRNA cleavage stimulating factor complex",
        "go_biological_process": "GO:0031124 mRNA 3'-end processing;GO:0031440 regulation of mRNA 3'-end processing",
        "synthesized_glycan_count": 0,
        "hit_score": 15.3,
        "record_id": "Q05048-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P62829-1",
        "uniprot_id": "RL23_HUMAN",
        "mass": 14865.0,
        "length": 140,
        "protein_name": "Large ribosomal subunit protein uL14",
        "gene_name": "RPL23",
        "organism": "Human",
        "refseq_name": "large ribosomal subunit protein uL14",
        "refseq_ac": "NP_000969",
        "gene_names_uniprotkb": "RPL23",
        "gene_names_refseq": "L23; RPL23; rpL17; uL14",
        "protein_names_uniprotkb": "Large ribosomal subunit protein uL14; 60S ribosomal protein L17; 60S ribosomal protein L23",
        "protein_names_refseq": "60S ribosomal protein L17; 60S ribosomal protein L23; large ribosomal subunit protein uL14; ribosomal protein L17",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9349);  (R-HSA-156827);  (R-HSA-156902);  (R-HSA-1799339);  (R-HSA-192823);  (R-HSA-2408557);  (R-HSA-6791226);  (R-HSA-72689);  (R-HSA-72706);  (R-HSA-72764);  (R-HSA-9010553);  (R-HSA-9633012);  (R-HSA-975956);  (R-HSA-975957);  (R-HSA-9954709);  (R-HSA-9954714);  (R-HSA-9954716)",
        "pathway_count": 17,
        "publication_count": 270,
        "publication_id_list": "10358005;10659855;1095581;10970870;10982836;11018020;11018027;11237011;11265756;11331269;11532962;11544179;11546874;11551508;11677247;11691921;11726970;11875025;11922599;11964406;12068309;12150911;12417715;12493757;12554878;12588972;12718880;12832468;12853463;1400365;14527413;14567916;14630918;14636577;14742663;14973490;15034551;15317934;15385533;15534230;15546618;15592455;15721257;15775988;15781252;15821744;16026328;16037817;16043514;16186820;16209946;16284618;16452507;16469117;16601204;16622410;16630668;16738141;16989641;17053788;17142313;17189298;17267404;17308301;17352659;17353269;17363904;17412707;17726049;17803942;17893241;18065403;18066079;18166647;18230761;18256688;18285520;18423202;18438418;18447580;18447585;18455985;18524595;18539146;1856230;1861871;1861993;18657639;18691976;1874450;18974281;19060897;19106111;19150429;19332556;19359157;19417104;19478851;19503078;19556969;19564402;19608919;19706539;19801658;19859661;19909264;20023408;20038530;20056613;2006156;20068231;20361218;20444697;20479275;20531386;20691628;20798176;20805244;20817927;20819938;20930030;21029861;21036871;21063389;21097556;21145460;21419344;21740066;22072790;22121020;22190735;22195017;22916032;23085078;23217742;23234702;23269699;23439679;23481700;23482395;23636399;23685075;23746841;23783831;2388630;24424021;24524803;24550520;24714562;24715725;25132172;25242263;25418920;25469497;25525153;25576301;25578875;25969445;26154972;26237581;26728094;26758079;26929215;26992070;27526673;27600516;27846572;27920218;28063628;28065601;28132843;28218747;28228285;28510447;28649982;28685749;28832583;28904123;29242379;29317506;29393594;29413899;29437277;29493099;29508533;29557506;29632046;29632312;29632711;29789417;30192525;30244831;30293783;30315122;30804176;31011209;31217245;31222486;31530632;31844290;31848261;31937595;31998317;32099016;32119511;32157095;32161166;32265295;32350084;32387766;32488085;32502341;32579943;32669547;32870666;32938616;32983136;33091337;33141586;33214551;33298915;33392160;33406423;33592498;33691108;33909987;33912179;33936100;33968037;33981976;34019948;34171305;34357683;34509645;34561969;34725712;34932366;35051231;35083852;35138101;35154160;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36302773;37217939;37676773;37938771;38665916;429297;592398;592399;641056;6568109;6901506;7990965;8336711;8407925;8890909;9211906;9431993;9482744;9631292;9637248;9712840",
        "class_list": "",
        "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P23131;P24048;Q29246;Q3SWV7;Q6P5S1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0031625 ubiquitin protein ligase binding;GO:0001223 transcription coactivator binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0003735 structural constituent of ribosome",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005925 focal adhesion",
        "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0006610 ribosomal protein import into nucleus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 27.3,
        "record_id": "P62829-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14511-1",
        "uniprot_id": "CASL_HUMAN",
        "mass": 92861.0,
        "length": 834,
        "protein_name": "Enhancer of filamentation 1",
        "gene_name": "NEDD9",
        "organism": "Human",
        "refseq_name": "enhancer of filamentation 1 isoform 3",
        "refseq_ac": "NP_001135865",
        "gene_names_uniprotkb": "NEDD9; CASL",
        "gene_names_refseq": "CAS-L; CAS2; CASL; CASS2; HEF1; NEDD9",
        "protein_names_uniprotkb": "Enhancer of filamentation 1; CAS-L; CASS2; CRK-associated substrate-related protein; Cas scaffolding protein family member 2; CasL; NEDD-9; Neural precursor cell expressed developmentally down-regulated protein 9; Renal carcinoma antigen NY-REN-12; hEF1; p105",
        "protein_names_refseq": "Cas scaffolding protein family member 2; Crk-associated substrate related protein Cas-L; Enhancer of filamentation 1 p55; cas-like docking; enhancer of filamentation 1 isoform 3; neural precursor cell expressed developmentally down-regulated protein 9; p130Cas-related protein; renal carcinoma antigen NY-REN-12",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4739)",
        "pathway_count": 1,
        "publication_count": 112,
        "publication_id_list": "10502414;10508479;11054566;11237011;11827972;12522270;15051726;15144186;16184168;16394104;16497976;17074750;17174122;17604723;18083107;18446792;19103205;19275884;19539609;22424782;22544926;22609948;22810897;22898188;23481700;23874939;24574519;24714562;24715725;25576301;25645385;25880248;25892735;26154972;26375851;26728094;26992070;27397612;27600516;27846572;28228285;28446606;28832583;28834231;29191835;29242379;29331515;29351928;29393594;29485866;29493099;29508533;29557506;29632711;29769354;29786170;29789417;29899023;30315122;30429286;30524438;30779550;31154438;31217245;31222486;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33392160;33537174;33592498;33717175;33912179;33936100;33968037;34078123;34087483;34211107;34357683;34509645;34932366;35051231;35154160;35318648;35561310;35577404;35580925;36010968;36203318;36215666;36284347;36581221;37938771;39060928;39326322;40914422;8668148;8879209;9020138;9360983;9497377;9584194",
        "class_list": "",
        "function": "Combined high NEDD9 expression and E-cadherin loss correlate with poor clinical outcome in gastric cancer., [RefSeq, PubMed]; NEDD9 Mediates the FAK/Src Signaling Pathway to Promote the Adhesion of Human Trabecular Meshwork Cells after Dexamethasone Treatment., [RefSeq, PubMed]; NEDD9 is transcriptionally regulated by HDAC4 and promotes breast cancer metastasis and macrophage M2 polarization via the FAK/NF-kappaB signaling pathway., [RefSeq, PubMed]; Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]., [RefSeq]; Transcription factor 7 like 2 promotes metastasis in hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 22,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9G7;A8MSJ9;G5E9Y9;Q5T9R4;Q5XKI0",
        "ec_number_list": "",
        "go_molecular_function": "GO:1990782 protein tyrosine kinase binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0007611 learning or memory",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "Q14511-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O94955-1",
        "uniprot_id": "RHBT3_HUMAN",
        "mass": 69413.0,
        "length": 611,
        "protein_name": "Rho-related BTB domain-containing protein 3",
        "gene_name": "RHOBTB3",
        "organism": "Human",
        "refseq_name": "rho-related BTB domain-containing protein 3",
        "refseq_ac": "NP_055714",
        "gene_names_uniprotkb": "RHOBTB3; KIAA0878",
        "gene_names_refseq": "RHOBTB3",
        "protein_names_uniprotkb": "Rho-related BTB domain-containing protein 3; 3.6.1.-",
        "protein_names_refseq": "rho-related BTB domain-containing protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22836);  (R-HSA-6811440);  (R-HSA-9706019)",
        "pathway_count": 3,
        "publication_count": 134,
        "publication_id_list": "10209123;10445031;10559959;10637310;10865125;10990452;11237011;11303027;11346801;11359012;11689439;11827983;11839770;12070132;12377769;12426103;12620188;12620189;14580338;14718928;15029241;15037235;15077113;15077114;15128430;15269279;15483056;15654769;15758030;15870108;15878329;16042553;16129887;16571679;16885419;16912714;16936697;17451557;17488291;17562788;17684057;17698061;18195106;18243103;18256213;18367545;18664496;18946081;19019082;19164740;19490898;19620288;20685960;21183348;21421921;21436057;21689688;21807881;22245496;22335553;22354037;22581368;22709582;22717455;23091056;23437303;24145166;24794632;25343031;25418920;25576301;25645385;25880248;25892735;26215701;26992070;27846572;27862975;28834231;28904123;29437277;29493099;29557506;29741879;30410026;30429286;30484775;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32720791;32897882;32938616;33298915;33392160;33537174;33592498;33633747;33912179;33968037;33981976;34087483;34171305;34185709;34357683;34416910;34561969;34932366;35051231;35251023;35318648;35580925;35698915;36010968;36215666;36241641;36284347;36939994;37938771;7909812;8221884;8440258;8620540;8636227;8670882;9050864;9177194;9230071;9590177",
        "class_list": "",
        "function": "Circular RNA circRHOBTB3 inhibits ovarian cancer progression through PI3K/AKT signaling pathway., [RefSeq, PubMed]; FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; NR1H4-mediated circRHOBTB3 modulates the proliferation, metastasis, and Warburg effects of cervical cancer through interacting with IGF2BP3., [RefSeq, PubMed]; Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9., [UniProtKB, PubMed]; RhoBTB3 Regulates Proliferation and Invasion of Breast Cancer Cells via Col1a1., [RefSeq, PubMed]; Study reports that the atypical Rho GTPase family member, RhoBTB3, binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 8796,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0PJA4;A8K1W9;Q8IW06",
        "ec_number_list": "3.6.1.-;3.6.5.2",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031625 ubiquitin protein ligase binding;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis;GO:0042147 retrograde transport, endosome to Golgi",
        "synthesized_glycan_count": 0,
        "hit_score": 13.8,
        "record_id": "O94955-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P14210-1",
        "uniprot_id": "HGF_HUMAN",
        "mass": 83134.0,
        "length": 728,
        "protein_name": "Hepatocyte growth factor",
        "gene_name": "HGF",
        "organism": "Human",
        "refseq_name": "hepatocyte growth factor isoform 1 preproprotein",
        "refseq_ac": "NP_000592",
        "gene_names_uniprotkb": "HGF; HPTA",
        "gene_names_refseq": "DFNB39; F-TCF; HGFB; HGF; HPTA; SF",
        "protein_names_uniprotkb": "Hepatocyte growth factor; Hepatopoietin-A; SF; Scatter factor",
        "protein_names_refseq": "fibroblast-derived tumor cytotoxic factor; hepatocyte growth factor (hepapoietin A; hepatocyte growth factor isoform 1 preproprotein; hepatopoietin-A; lung fibroblast-derived mitogen; scatter factor)",
        "tax_id": 9606,
        "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); limb ischemia (Disease Ontology:DOID:0050852); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); COVID-19 (Disease Ontology:DOID:0080600); polymyositis (Disease Ontology:DOID:0080745); graft-versus-host disease (Disease Ontology:DOID:0081267); autosomal recessive nonsyndromic deafness 39 (Disease Ontology:DOID:0110497); keratoconus (Disease Ontology:DOID:10126); dermatomyositis (Disease Ontology:DOID:10223); retinitis pigmentosa (Disease Ontology:DOID:10584); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); myopia (Disease Ontology:DOID:11830); vitiligo (Disease Ontology:DOID:12306); retinopathy of prematurity (Disease Ontology:DOID:13025); angle-closure glaucoma (Disease Ontology:DOID:13550); adult-onset Still's disease (Disease Ontology:DOID:14256); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); bilirubin metabolic disorder (Disease Ontology:DOID:2741); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); interstitial lung disease (Disease Ontology:DOID:3082); inverted papilloma (Disease Ontology:DOID:3179); central nervous system disease (Disease Ontology:DOID:331); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); brain infarction (Disease Ontology:DOID:3454); meningioma (Disease Ontology:DOID:3565); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); cholangiocarcinoma (Disease Ontology:DOID:4947); myocardial infarction (Disease Ontology:DOID:5844); myositis (Disease Ontology:DOID:633); rheumatoid arthritis (Disease Ontology:DOID:7148); retinal degeneration (Disease Ontology:DOID:8466); localized scleroderma (Disease Ontology:DOID:8472); cholesteatoma (Disease Ontology:DOID:869); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:3082);  (R-HSA-114608);  (R-HSA-1257604);  (R-HSA-1266695);  (R-HSA-2219530);  (R-HSA-5673001);  (R-HSA-6785807);  (R-HSA-6806942);  (R-HSA-6807004);  (R-HSA-6811558);  (R-HSA-8851805);  (R-HSA-8851907);  (R-HSA-8865999);  (R-HSA-8874081);  (R-HSA-8875513);  (R-HSA-8875555);  (R-HSA-8875656);  (R-HSA-8875791);  (R-HSA-9734091)",
        "pathway_count": 19,
        "publication_count": 375,
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        "class_list": "",
        "function": "A HGF Mutation in the Familial Case of Primary Lymphedema: A Report. Publication Status: Online-Only, [RefSeq, PubMed]; Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients., [RefSeq, PubMed]; Differential Immune Checkpoint Protein Expression in HNSCC: The Role of HGF/MET Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Pathogenic variants in HGF give rise to childhood-to-late onset primary lymphoedema by loss of function., [RefSeq, PubMed]; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (PubMed:15167892, PubMed:20977675). Activates MAPK signaling following TMPRSS13 cleavage and activation (PubMed:20977675)., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 105,
        "reported_interactions": 1,
        "missing_score": 0,
        "biomarker_type": "prognostic",
        "glycan_count": 31,
        "disease_count": 46,
        "glyco_site_count": 5,
        "binding_glycan_count": 1,
        "secondary_ac_list": "A1L3U6;Q02935;Q13494;Q14519;Q3KRB2;Q8TCE2;Q9BYL9;Q9BYM0;Q9UDU6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane;GO:0031093 platelet alpha granule lumen",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030335 positive regulation of cell migration;GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 41.2,
        "record_id": "P14210-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O94842-1",
        "uniprot_id": "TOX4_HUMAN",
        "mass": 66195.0,
        "length": 621,
        "protein_name": "TOX high mobility group box family member 4",
        "gene_name": "TOX4",
        "organism": "Human",
        "refseq_name": "TOX high mobility group box family member 4 isoform 2",
        "refseq_ac": "NP_001290452",
        "gene_names_uniprotkb": "TOX4; C14orf92; KIAA0737",
        "gene_names_refseq": "C14orf92; KIAA0737; LCP1; MIG7; TOX4",
        "protein_names_uniprotkb": "TOX high mobility group box family member 4",
        "protein_names_refseq": "TOX high mobility group box family member 4 isoform 2; epidermal Langerhans cell protein LCP1; migration-inducing protein 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9878)",
        "pathway_count": 1,
        "publication_count": 109,
        "publication_id_list": "11237011;17081983;18452278;18669648;19293638;19413330;19651622;20058876;20068231;20112406;20516061;23186163;23301498;23481700;24129315;24275569;24366607;25418920;25576301;25645385;25880248;26154972;26375851;26992070;27600516;27846572;27920218;28063628;28228285;28514659;28657654;28832583;28860189;28904123;29242379;29351928;29393594;29508533;29557506;29632046;29786170;30059200;30315122;30379171;30429286;30620550;30779550;31154438;31217245;31222486;31373491;31492838;31530632;31844290;31848261;31998317;32119511;32157095;32161166;32265295;32357974;32387766;32502341;32574038;32938616;32938750;32983136;33123756;33214551;33592498;33691108;33912179;33936100;33968037;33981976;34019948;34357683;34509645;34561969;34725712;34846842;34914893;34932366;35051231;35132862;35138101;35254053;35289036;35365735;35513511;35561310;35580925;35705054;36010968;36215666;36241641;36284347;37340703;37541260;37789777;38665916;38838015;39302247;39531497;39534244;39603239;39603240;40307207;40596516",
        "class_list": "",
        "function": "Migration-inducing gene-7 promotes glioma cell proliferation and invasiveness via activating the MAPK signaling pathway., [RefSeq, PubMed]; TOX4 facilitates promoter-proximal pausing and C-terminal domain dephosphorylation of RNA polymerase II in human cells. Publication Status: Online-Only, [RefSeq, PubMed]; TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver., [RefSeq, PubMed]; The coordinated spatial and temporal regulation of LCP1 and PNUTS may be a novel mechanism to control the expression of genes that are critical for certain physiological and pathological processes., [RefSeq, PubMed]; Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1 (By similarity). This regulation is independent of the insulin receptor activation (By similarity). Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes (PubMed:39603239, PubMed:39603240). Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (PubMed:39603239, PubMed:39603240). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 15,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 15,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 15,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 20,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 16,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DPY8;B4DSM0;E7EV69",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031490 chromatin DNA binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0072357 PTW/PP1 phosphatase complex;GO:0005694 chromosome",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0001111 RNA polymerase II promoter clearance;GO:0032968 positive regulation of transcription elongation by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 12.7,
        "record_id": "O94842-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13501-1",
        "uniprot_id": "SQSTM_HUMAN",
        "mass": 47687.0,
        "length": 440,
        "protein_name": "Sequestosome-1",
        "gene_name": "SQSTM1",
        "organism": "Human",
        "refseq_name": "sequestosome-1 isoform 2",
        "refseq_ac": "NP_001135770",
        "gene_names_uniprotkb": "SQSTM1; ORCA; OSIL",
        "gene_names_refseq": "A170; DMRV; EBIAP; FTDALS3; NADGP; OSIL; PDB3; SQSTM1; ZIP3; p60; p62B; p62",
        "protein_names_uniprotkb": "Sequestosome-1; EBI3-associated protein of 60 kDa; EBIAP; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62; p60; p62",
        "protein_names_refseq": "EBI3-associated protein of 60 kDa; EBI3-associated protein p60; autophagy receptor p62; oxidative stress induced like; phosphotyrosine independent ligand for the Lck SH2 domain p62; phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; sequestosome-1 isoform 2; ubiquitin-binding protein p62",
        "tax_id": 9606,
        "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); distal myopathy with rimmed vacuoles (Disease Ontology:DOID:0081363); neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset (Disease Ontology:DOID:0081364); Paget's disease of bone 3 (Disease Ontology:DOID:0081366); frontotemporal dementia and/or amyotrophic lateral sclerosis 3 (Disease Ontology:DOID:0110068); hypertension (Disease Ontology:DOID:10763); glaucoma (Disease Ontology:DOID:1686); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); Paget's disease of bone (Disease Ontology:DOID:5408); acute myocardial infarction (Disease Ontology:DOID:9408)",
        "pathway": " (hsa:8878);  (R-HSA-205043);  (R-HSA-209543);  (R-HSA-209560);  (R-HSA-5205685);  (R-HSA-8951664);  (R-HSA-9020702);  (R-HSA-9664873);  (R-HSA-9725370);  (R-HSA-9755511);  (R-HSA-9759194)",
        "pathway_count": 11,
        "publication_count": 556,
        "publication_id_list": 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        "class_list": "",
        "function": "A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements., [RefSeq, PubMed]; Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence., [RefSeq, PubMed]; Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024, PubMed:40542578). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; TRIM44 enhances autophagy via SQSTM1 oligomerization in response to oxidative stress. Publication Status: Online-Only, [RefSeq, PubMed]; The Autophagy Receptor SQSTM1/p62 Is a Restriction Factor of HCMV Infection. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 45,
        "reported_mutagensis": 37,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 10,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NFN7;B2R661;B3KUW5;Q13446;Q9BUV7;Q9BVS6;Q9UEU1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:0001659 temperature homeostasis;GO:0002931 response to ischemia;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 56.0,
        "record_id": "Q13501-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96BD5-1",
        "uniprot_id": "PF21A_HUMAN",
        "mass": 74854.0,
        "length": 680,
        "protein_name": "PHD finger protein 21A",
        "gene_name": "PHF21A",
        "organism": "Human",
        "refseq_name": "PHD finger protein 21A isoform a",
        "refseq_ac": "NP_001095272",
        "gene_names_uniprotkb": "PHF21A; BHC80; BM-006; KIAA1696",
        "gene_names_refseq": "BHC80; BM-006; IDDBCS; NEDMS; PHF21A",
        "protein_names_uniprotkb": "PHD finger protein 21A; BHC80a; BRAF35-HDAC complex protein BHC80",
        "protein_names_refseq": "BHC80a; BRAF35-HDAC complex protein BHC80; BRAF35/HDAC2 complex (80 kDa); PHD finger protein 21A isoform a",
        "tax_id": 9606,
        "disease": "intellectual developmental disorder with behavioral abnormalities and craniofacial dysmorphism with or without seizures (MONDO:MONDO:0032883)",
        "pathway": " (hsa:51317);  (R-HSA-3214815);  (R-HSA-9679191);  (R-HSA-983231)",
        "pathway_count": 4,
        "publication_count": 144,
        "publication_id_list": "10.1101/2023.09.13.557529;10087012;10444591;10449787;10748112;10904264;10922406;10926844;11042108;11062261;11237011;11242053;11509652;11739383;11742974;11744692;11751636;11895428;11909966;11950885;12032298;12134158;12427746;12493763;12724404;15020713;15247287;15325272;15710388;16054028;16115318;16140033;1630448;16522641;17027967;17196961;17211407;17662961;19293402;19690332;20223979;20530532;20627800;21587264;218813;22401777;22552008;22661428;22814904;23186163;23301498;23481700;23641311;24272870;24584101;24715725;25218447;25576301;25801024;26002965;26101246;26375851;26845023;26992070;27846572;27920218;28228285;28425720;28657654;28832583;28834231;28904123;29237092;29242379;29351928;29393594;29508533;29557506;29632711;29769354;29786170;29945920;30059200;30201761;30379171;30429286;30487643;30620550;31048504;31492838;31649809;31844290;32157095;32502341;32574038;32938616;32938750;32983136;33123756;33141586;33214551;33298915;33392160;33592498;33633747;33968037;34019948;34087483;3409321;34211107;34846842;34932366;35051231;35132862;35254053;35289036;35513511;35705054;36240223;36284347;36305691;36843358;37340703;37541260;38665916;39302247;39531497;39534244;40136647;40307207;40596516;41350704;7513682;8662638;8816476;9065479;9150135;9230307;9326583;9331217;9422515;9651585;9790534;9927674",
        "class_list": "",
        "function": "A novel de novo variant in the PHF21A causes craniofacial abnormalities, intellectual disability and skeletal manifestations., [RefSeq, PubMed]; Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation., [UniProtKB, PubMed]; PHF21A expression as a biomarker of hepatocellular carcinoma progression and prognosis., [RefSeq, PubMed]; Presumably serves as a scaffold protein in BHC in neuronal as well as non-neuronal cells. Possible role in spermatogenesis., [RefSeq, PubMed]; The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 17,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 17,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 17,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 19,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DQP5;Q6AWA2;Q9C0G7;Q9H8V9;Q9HAK6;Q9NZE9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000118 histone deacetylase complex;GO:1990391 DNA repair complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 16.6,
        "record_id": "Q96BD5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14CW9-1",
        "uniprot_id": "AT7L3_HUMAN",
        "mass": 38651.0,
        "length": 347,
        "protein_name": "Ataxin-7-like protein 3",
        "gene_name": "ATXN7L3",
        "organism": "Human",
        "refseq_name": "ataxin-7-like protein 3 isoform a",
        "refseq_ac": "NP_001369237",
        "gene_names_uniprotkb": "ATXN7L3",
        "gene_names_refseq": "ATXN7L3; HATONS; SGF11",
        "protein_names_uniprotkb": "Ataxin-7-like protein 3; SAGA-associated factor 11 homolog",
        "protein_names_refseq": "ataxin-7-like protein 3 isoform a",
        "tax_id": 9606,
        "disease": "Harel-Tora neurodevelopmental syndrome (Disease Ontology:DOID:0070711)",
        "pathway": " (hsa:56970);  (R-HSA-3214847)",
        "pathway_count": 2,
        "publication_count": 34,
        "publication_id_list": "10786633;10821277;11237011;15313887;16387653;18206972;18381289;18452278;18623064;18669648;18691976;19187765;19664995;19690332;20018852;20068231;20634802;21406692;21746879;23186163;24275569;27601583;27920218;28218747;29437277;30429286;31844290;35051231;35192684;35316324;38753057;9427644;9558366;9880483",
        "class_list": "",
        "function": "Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, HAMAP, PubMed, PubMed, PubMed]; Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL., [RefSeq, PubMed]; Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IY68;Q96N40;Q9NPU5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0071819 DUBm complex;GO:0000124 SAGA complex;GO:0070461 SAGA-type complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0043484 regulation of RNA splicing",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q14CW9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15304-1",
        "uniprot_id": "SIVA_HUMAN",
        "mass": 18695.0,
        "length": 175,
        "protein_name": "Apoptosis regulatory protein Siva",
        "gene_name": "SIVA1",
        "organism": "Human",
        "refseq_name": "apoptosis regulatory protein Siva isoform 1",
        "refseq_ac": "NP_006418",
        "gene_names_uniprotkb": "SIVA1; SIVA",
        "gene_names_refseq": "CD27BP; SIVA1; SIVA; Siva-1; Siva-2",
        "protein_names_uniprotkb": "Apoptosis regulatory protein Siva; CD27-binding protein; CD27BP",
        "protein_names_refseq": "CD27-binding (Siva) protein; apoptosis regulatory protein Siva isoform 1; apoptosis regulatory protein Siva",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10572)",
        "pathway_count": 1,
        "publication_count": 41,
        "publication_id_list": "10756043;11237011;11278261;11601913;12011449;14739602;15034012;15958577;16491128;16683188;24275569;25576301;28514659;28904123;29242379;29493099;29508533;29786170;30315122;31154438;31530632;31844290;32161166;32329870;32387766;32488085;32626967;33298915;33592498;33936100;33968037;33981976;34171305;34211107;34561969;35580925;36307991;37303491;38722955;39894887;9177220",
        "class_list": "",
        "function": "Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1. Publication Status: Online-Only, [RefSeq, PubMed]; Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis., [RefSeq, PubMed]; PM2.5 exposure induces alveolar epithelial cell apoptosis and causes emphysema through p53/Siva-1., [RefSeq, PubMed]; Siva1 regulates multidrug resistance of gastric cancer by targeting MDR1 and MRP1 via the NFkappaB pathway., [RefSeq, PubMed]; This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 2,
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        "reported_snv": 5,
        "reported_interactions": 0,
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        "biomarker_type": "",
        "glycan_count": 1,
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        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96P98;Q9UPD6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding;GO:0001618 virus receptor activity;GO:0005175 CD27 receptor binding;GO:0005164 tumor necrosis factor receptor binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005634 nucleus",
        "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0097191 extrinsic apoptotic signaling pathway;GO:0097193 intrinsic apoptotic signaling pathway;GO:0006924 activation-induced cell death of T cells",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "O15304-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TAP4-1",
        "uniprot_id": "LMO3_HUMAN",
        "mass": 16594.0,
        "length": 145,
        "protein_name": "LIM domain only protein 3",
        "gene_name": "LMO3",
        "organism": "Human",
        "refseq_name": "LIM domain only protein 3 isoform 1",
        "refseq_ac": "NP_001001395",
        "gene_names_uniprotkb": "LMO3; RBTN3; RBTNL2; RHOM3",
        "gene_names_refseq": "LMO3; RBTN3; RBTNL2; RHOM3; Rhom-3",
        "protein_names_uniprotkb": "LIM domain only protein 3; LMO-3; Neuronal-specific transcription factor DAT1; Rhombotin-3",
        "protein_names_refseq": "LIM domain only 3 (rhombotin-like 2); LIM domain only protein 3 isoform 1; LIM domain only protein 3; dopamine associated transcription factor-1; neuronal-specific transcription factor DAT1; rhombotin-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55885)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;1507224;15930276;19995558;31844290;32502341;34018016;35165791;36413852;36426731;38366633",
        "class_list": "",
        "function": "Circ_0007385 promotes the proliferation and inhibits the apoptosis of non-small cell lung cancer cells via miR-337-3p-dependent regulation of LMO3., [RefSeq, PubMed]; Hyperglycemia affects neuronal differentiation and Nestin, FOXO1, and LMO3 mRNA expression of human Wharton's jelly mesenchymal stem cells of children from diabetic mothers., [RefSeq, PubMed]; LMO3 acts as a co-repressor of p53, suppressing p53-dependent transcriptional regulation without inhibition of its DNA-binding activity., [RefSeq, PubMed]; LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism., [RefSeq, PubMed]; LMO3 reprograms visceral adipocyte metabolism during obesity., [RefSeq, PubMed]; The deregulated expression of neuronal-specific LMO3 and HEN2 contributes to the genesis and progression of human neuroblastoma in a lineage-specific manner., [RefSeq, PubMed]; The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]., [RefSeq]; Transcriptomic analysis and biological evaluation reveals that LMO3 regulates the osteogenic differentiation of human adipose derived stem cells via PI3K/Akt signaling pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "secondary_ac_list": "B4DG90;B4DH35;Q58A66;Q58A67;Q8N974;Q9UDD5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045600 positive regulation of fat cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8TAP4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P31321-1",
        "uniprot_id": "KAP1_HUMAN",
        "mass": 43073.0,
        "length": 381,
        "protein_name": "cAMP-dependent protein kinase type I-beta regulatory subunit",
        "gene_name": "PRKAR1B",
        "organism": "Human",
        "refseq_name": "cAMP-dependent protein kinase type I-beta regulatory subunit",
        "refseq_ac": "NP_001158230",
        "gene_names_uniprotkb": "PRKAR1B",
        "gene_names_refseq": "MASNS; PRKAR1B; PRKAR1",
        "protein_names_uniprotkb": "cAMP-dependent protein kinase type I-beta regulatory subunit",
        "protein_names_refseq": "cAMP-dependent protein kinase type I-beta regulatory subunit; protein kinase, cAMP-dependent, regulatory subunit type I beta; protein kinase, cAMP-dependent, regulatory, type I, beta",
        "tax_id": 9606,
        "disease": "Marbach-Schaaf neurodevelopmental syndrome (MONDO:MONDO:0859214)",
        "pathway": " (hsa:5575);  (R-HSA-163615);  (R-HSA-164378);  (R-HSA-180024);  (R-HSA-381676);  (R-HSA-432040);  (R-HSA-442720);  (R-HSA-5610787);  (R-HSA-9634597);  (R-HSA-9660821);  (R-HSA-9664323);  (R-HSA-983231);  (R-HSA-9856530)",
        "pathway_count": 13,
        "publication_count": 355,
        "publication_id_list": "10075700;10318832;10376603;10496952;10579907;10604473;10639123;10649434;10714768;10764742;10861086;10966113;11034202;11042108;11043579;11062261;11071853;11076974;11237011;11242053;11375483;11744692;11751636;11773440;11853546;11895428;11950885;11968001;12032298;12034449;12036966;12065642;12106601;12117970;12134158;12176338;12180908;12192414;12194985;12401793;12410638;12417718;12427746;12435627;12475787;12496249;12724311;12801959;12860470;12938160;1325798;13680124;1372004;1373524;14514735;14592814;14603322;14675202;14701836;14988243;15020713;15087129;1510932;15161916;15245432;15247287;15304325;1534149;15539556;15569269;15703994;15705806;15710388;15718470;15879134;15930098;15955806;15995848;16054028;16061793;16120822;16136078;16229832;16254602;1630448;16311594;16339192;16396903;16407073;16407156;16493421;16613843;16613879;16645038;16707575;16777052;16780920;16921024;16973695;17027958;17027967;1708242;17095603;17156409;17178220;17196961;17200122;17306374;17379646;17442700;17444618;17535922;17553904;17641202;17762891;17900700;17960137;18070890;18202100;18202181;18287102;18327258;18412318;18455992;18511455;18566127;18577758;18669648;18678926;18691976;18710921;18818202;18832070;19000668;19020623;19144687;19170255;19196978;19223390;19286674;19293402;19342448;19365551;19383790;19549984;19574955;19592253;19666503;19690332;19723632;19741198;19767740;19776033;19859570;19861722;19877275;19906846;19931550;19948480;19996169;20067783;20154143;20207148;20395968;20412786;20460306;20530532;20627800;20819953;20844016;20889716;20956384;21037092;2105456;21209331;21695114;21801010;21844907;218813;22007132;22231273;22391300;22424782;22495674;22869377;22898188;23115245;23186163;23209152;23332756;23481700;23675550;23719536;24273487;24275569;24302888;24339784;24530924;24714562;24715725;24845016;24863049;24917297;24925320;24952464;24962572;25418920;2553705;25576301;25645385;25892735;26154972;26190834;26308095;26768311;26845023;26929215;26987903;26992070;27028580;27392633;27543614;27566546;27600516;27797339;27846572;27920218;28063628;28218747;28228285;28446606;28450397;28467828;28595943;28832583;28834231;28904123;29242379;29393594;29437277;29508533;29557506;29632046;29632711;29769354;29786170;2991279;30315122;30379171;30410026;3049610;30524438;3104109;31092671;31205027;31217245;3127824;31844290;32157095;32296767;32357974;32387766;32502341;32895490;32897882;32938616;32983136;33141586;33298915;33633747;33691108;33833410;33936100;33968037;33981976;3409321;34499618;34509645;34716310;34932366;35051231;35154160;35251023;35318648;35561310;35580925;36010968;36241641;38326651;4065330;6087160;6296685;6330098;6501302;7503232;7510718;7517665;7522622;7526388;7530449;7535000;7538665;7568118;7589461;7651538;7678419;7876172;7925653;8007951;8063828;8138058;8140421;8226994;8340414;8404634;8405712;8522976;8527267;8598224;8621513;8657103;8662638;8663227;8683474;8700127;8702633;8816476;8830891;8855281;8862523;9000504;9042338;9050880;9065479;9099992;9162098;9227644;9230307;9314552;9326583;9331217;9369468;9371714;9374639;9374640;9417641;9422515;9488697;9620797;9651336;9756892;9829975;9857068;9920805;9927674",
        "class_list": "",
        "function": "EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Genomic and sequence variants of protein kinase A regulatory subunit type 1beta (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome. Erratum:[Genet Med. 2021 Jan;23(1):239. doi: 10.1038/s41436-020-01018-4. PMID: 33082560], [RefSeq, PubMed]; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells., [UniProtKB, PubMed]; The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]., [RefSeq]; Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
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        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N422",
        "ec_number_list": "",
        "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0008603 cAMP-dependent protein kinase regulator activity;GO:0030552 cAMP binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0098794 postsynapse",
        "go_biological_process": "GO:0003091 renal water homeostasis;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0034199 activation of protein kinase A activity;GO:0071377 cellular response to glucagon stimulus;GO:1900273 positive regulation of long-term synaptic potentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 35.8,
        "record_id": "P31321-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q12815-1",
        "uniprot_id": "TROAP_HUMAN",
        "mass": 83857.0,
        "length": 778,
        "protein_name": "Tastin",
        "gene_name": "TROAP",
        "organism": "Human",
        "refseq_name": "tastin isoform 2",
        "refseq_ac": "NP_001094090",
        "gene_names_uniprotkb": "TROAP",
        "gene_names_refseq": "TASTIN; TROAP",
        "protein_names_uniprotkb": "Tastin; Trophinin-assisting protein; Trophinin-associated protein",
        "protein_names_refseq": "tastin isoform 2; trophinin assisting protein; trophinin-assisting protein (tastin)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10024)",
        "pathway_count": 1,
        "publication_count": 63,
        "publication_id_list": "11237011;12049630;16964243;18669648;18691976;19007248;19690332;20068231;23186163;23481700;24715725;25418920;25576301;26154972;26992070;27846572;28228285;28832583;28834231;29242379;29508533;29632046;30059200;30315122;30620550;31092671;31844290;32157095;32350084;32387766;32488085;32502341;32897882;32938616;32938750;32983136;33214551;33298915;33592498;33936100;33968037;33981976;34019948;34171305;34287099;34509645;34846842;34932366;35051231;35132862;35254053;35513511;35705054;36691332;37298609;37340703;37608033;39302247;39531497;40136647;40307207;41350704;7758945",
        "class_list": "",
        "function": "Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation., [UniProtKB]; METTL3 regulatory TROAP can regulate the progression of non-small cell lung cancer through PI3K/AKT and EMT signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-532-3p suppresses cell viability, migration and invasion of clear cell renal cell carcinoma through targeting TROAP., [RefSeq, PubMed]; Plays an important role in mammalian cells by associating with the microtubular cytoskeleton, [RefSeq, PubMed]; TROAP Promotes the Proliferation, Migration, and Metastasis of Kidney Renal Clear Cell Carcinoma with the Help of STAT3. Publication Status: Online-Only, [RefSeq, PubMed]; Tastin promotes non-small-cell lung cancer progression through the ErbB4, PI3K/AKT, and ERK1/2 pathways., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 19,
        "reported_mutagensis": 0,
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        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F8VSF9;Q6PJU7;Q8N5B2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007155 cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "Q12815-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P52758-1",
        "uniprot_id": "RIDA_HUMAN",
        "mass": 14494.0,
        "length": 137,
        "protein_name": "2-iminobutanoate/2-iminopropanoate deaminase",
        "gene_name": "RIDA",
        "organism": "Human",
        "refseq_name": "2-iminobutanoate/2-iminopropanoate deaminase",
        "refseq_ac": "NP_005827",
        "gene_names_uniprotkb": "RIDA; HRSP12",
        "gene_names_refseq": "HRSP12; P14.5; PSP; RIDA; UK114; hp14.5",
        "protein_names_uniprotkb": "2-iminobutanoate/2-iminopropanoate deaminase; 14.5 kDa translational inhibitor protein; 3.5.99.10; Heat-responsive protein 12; Reactive intermediate imine deaminase A homolog; Translation inhibitor L-PSP ribonuclease; UK114 antigen homolog; hp14.5; p14.5",
        "protein_names_refseq": "14.5 kDa translational inhibitor protein; 2-iminobutanoate/2-iminopropanoate deaminase; UK114 antigen homolog; heat-responsive protein 12; perchloric acid-soluble protein; reactive intermediate imine deaminase A homolog; ribonuclease UK114; translation inhibitor L-PSP ribonuclease; translational inhibitor p14.5; translational inhibitor protein p14.5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10247);  (R-HSA-8849175)",
        "pathway_count": 2,
        "publication_count": 71,
        "publication_id_list": "11237011;14997576;15689518;18342636;20068231;20306345;20817725;22094463;22544926;23386433;23481700;24275569;24715725;25418920;25645385;25975565;26154972;26375851;26992070;28228285;28467828;28832583;29242379;29314611;29493099;29508533;29557506;29786170;30524438;30573663;30779550;30930054;31103411;31154438;31217245;31844290;31848261;31998317;32157095;32161166;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33109704;33141586;33298915;33392160;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34405274;34509645;35051231;35561310;36010968;36215666;36241641;36434386;8973653;9141440",
        "class_list": "",
        "function": "Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex (PubMed:30930054, PubMed:8973653). Acts by bridging YTHDF2 and the ribonuclease P/MRP complex (PubMed:30930054). RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage (PubMed:30930054)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; P14.5 functions to inhibit cell migration and can be used as a prognostic marker in hepatocellular carcinoma., [RefSeq, PubMed]; The new findings regarding the biological significance of enamine and imine production and outline the importance of RidA in controlling the accumulation of reactive metabolites. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6FHU9;Q6IBG0",
        "ec_number_list": "3.5.99.10",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019239 deaminase activity;GO:0016892 RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism;GO:0120242 2-iminobutanoate deaminase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome",
        "go_biological_process": "GO:0019518 L-threonine catabolic process to glycine;GO:0006629 lipid metabolic process;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process;GO:0061157 mRNA destabilization",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "P52758-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P53355-1",
        "uniprot_id": "DAPK1_HUMAN",
        "mass": 160046.0,
        "length": 1430,
        "protein_name": "Death-associated protein kinase 1",
        "gene_name": "DAPK1",
        "organism": "Human",
        "refseq_name": "death-associated protein kinase 1",
        "refseq_ac": "NP_001275658",
        "gene_names_uniprotkb": "DAPK1; DAPK",
        "gene_names_refseq": "DAPK1; DAPK; ROCO3",
        "protein_names_uniprotkb": "Death-associated protein kinase 1; 2.7.11.1; DAP kinase 1",
        "protein_names_refseq": "DAP kinase 1; death-associated protein kinase 1",
        "tax_id": 9606,
        "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); uterine fibroid (Disease Ontology:DOID:13223); anemia (Disease Ontology:DOID:2355)",
        "pathway": " (hsa:1612);  (R-HSA-418889)",
        "pathway_count": 2,
        "publication_count": 110,
        "publication_id_list": "10629061;11237011;11248093;11573098;11579085;11980920;12011067;12730201;14505650;14978097;15310786;15367680;15573119;15616583;15729359;16132846;16158190;16213824;16756490;17056602;17324930;17344846;17703233;17803936;17895359;18195017;18422656;18974095;18991276;18995835;19180116;19878313;20220139;20389280;21406692;21408167;21497122;22449708;22988864;23186163;23305096;23481700;24275569;24715725;25505266;25576301;25645385;25741596;25890206;25892735;26100670;26375851;26992070;27068745;27846572;27862975;27920218;28063628;28228285;28514659;28832583;28904123;29113343;29242379;29393594;29508533;29557506;29632046;29665256;29769354;29786170;30315122;30429286;31154438;31530632;31844290;31848261;32157095;32265295;32357974;32488085;32502341;32938616;32977471;32983136;33141586;33298915;33717175;33912179;33936100;33968037;34171305;34211107;34561969;34932366;35051231;35154442;35318648;35494241;35580925;36010968;36284347;36581221;38142898;38282318;38438055;38787485;38925973;7828849;9796814",
        "class_list": "",
        "function": "BNIP3 and DAPK1 methylation in peripheral blood leucocytes are noninvasive biomarkers for gastric cancer., [RefSeq, PubMed]; Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition., [UniProtKB]; Circ1811 suppresses gastric cancer progression by regulating the miR-632/DAPK1 axis., [RefSeq, PubMed]; Death associated protein kinase 1 predicts the prognosis and the immunotherapy response of various cancers. Erratum:[Mol Biol Rep. 2024 Jul 23;51(1):846. doi: 10.1007/s11033-024-09709-w. PMID: 39042224] Publication Status: Online-Only, [RefSeq, PubMed]; Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]., [RefSeq]; Frequent CDKN2B/P15 and DAPK1 methylation in duodenal follicular lymphoma is related to duodenal reactive lymphoid hyperplasia., [RefSeq, PubMed]; Isoform 2 cannot induce apoptosis but can induce membrane blebbing., [UniProtKB]; The targeting of DAPK1 with miR-190a-3p promotes autophagy in trophoblast cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 15,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
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        "secondary_ac_list": "B7ZLD2;B7ZLE7;Q14CQ7;Q1W5W0;Q68CP8;Q6ZRZ3;Q9BTL8",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005525 GTP binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0010506 regulation of autophagy;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.1,
        "record_id": "P53355-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P35372-1",
        "uniprot_id": "OPRM_HUMAN",
        "mass": 44779.0,
        "length": 400,
        "protein_name": "Mu-type opioid receptor",
        "gene_name": "OPRM1",
        "organism": "Human",
        "refseq_name": "mu-type opioid receptor isoform MOR-1",
        "refseq_ac": "NP_000905",
        "gene_names_uniprotkb": "OPRM1; MOR1",
        "gene_names_refseq": "LMOR; M-OR-1; MOP; MOR1; MOR; OPRM1; OPRM",
        "protein_names_uniprotkb": "Mu-type opioid receptor; M-OR-1; MOP; MOR-1; Mu opiate receptor; Mu opioid receptor; hMOP",
        "protein_names_refseq": "mu opiate receptor; mu opioid receptor hMOR-1a; mu-type opioid receptor isoform MOR-1",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); opioid abuse (Disease Ontology:DOID:11206); sciatic neuropathy (Disease Ontology:DOID:11446); extrahepatic cholestasis (Disease Ontology:DOID:13619); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); drug psychosis (Disease Ontology:DOID:1742); post-traumatic stress disorder (Disease Ontology:DOID:2055); brain ischemia (Disease Ontology:DOID:2316); opiate dependence (Disease Ontology:DOID:2559); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); schizophrenia (Disease Ontology:DOID:5419); rheumatoid arthritis (Disease Ontology:DOID:7148); neonatal abstinence syndrome (Disease Ontology:DOID:9828); obesity (Disease Ontology:DOID:9970); drug dependence (Disease Ontology:DOID:9974); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)",
        "pathway": " (hsa:4988);  (R-HSA-111885);  (R-HSA-202040);  (R-HSA-375276);  (R-HSA-418594);  (R-HSA-6785807);  (R-HSA-9022699)",
        "pathway_count": 7,
        "publication_count": 261,
        "publication_id_list": "10023775;10079109;10100623;10215864;10219247;10369418;10381885;10393893;10419536;10421367;10421368;10438732;10461880;10498338;10499587;10510379;10529478;10586089;10604470;10836142;10854085;10867011;10899166;10899953;10908300;11007482;11058569;11060299;11084045;11104795;11120780;11134674;11237011;11278437;11278523;11278729;11322507;11356008;11385580;11404481;11457843;11463377;11562423;11683476;11773063;11773858;11773859;11786497;11960372;12068084;12120503;12123746;12223527;12242343;12413885;12427552;12519790;12540846;12589820;12600988;12719537;12734358;1280419;12810704;12832402;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;14573758;14634100;14712222;15037869;15086512;15116091;15139756;15261459;15272312;15539556;15584925;1567413;15778451;15805299;15869882;15893644;15947423;15950906;15951850;15967873;16007214;16046395;16048438;16107692;16205632;16236134;16387451;16397018;16415903;16451196;16510571;16540365;16542645;1655761;16580639;16606674;16634148;16682505;16682632;16892066;16906017;16923326;1710450;1710578;1719979;1722333;17224450;17427945;17458857;17572495;18127230;18243101;18353781;18434541;18447642;1847994;18577758;18644974;19077058;19103668;19124156;19185846;19300905;19397496;19438807;19528658;19788913;20214800;20493732;20525224;21102457;21252155;21277709;21689689;21730069;21919606;21937440;21994466;22046235;22205702;22383755;22693070;22851691;23086340;23124025;23172665;23446738;23455323;23555662;23690594;23967200;24097101;24150225;24715725;24743777;24906252;25234944;2534964;25424712;26214522;2649896;2748346;27496565;2834384;31844290;3202875;3366244;35051231;3525564;3856870;38922774;38949208;6274691;6281660;6373251;6589611;7057924;7488213;7510216;7512451;7524088;7529288;7590751;7592910;7592911;7624359;7795521;7796300;7797512;7891175;7898939;7905839;7907877;7937899;7957926;8015379;8035319;8062389;8063797;8073283;8085155;8185599;8201839;8208289;8248172;8294032;8373420;8381365;8383682;8395824;8406495;8440682;8463333;8503909;8521505;8602263;8615752;8621622;8663118;8666380;8668165;8702752;873923;8797861;8816495;8823230;9013879;9171878;9193881;9312100;9399694;9521323;9530155;9544801;9593744;9607765;9651359;9685625;9689128;9722565;9723655;9736340;9792798;9822675;9832121;9851594;9874564",
        "class_list": "",
        "function": "Couples to GNAS and is proposed to be involved in excitatory effects., [UniProtKB, PubMed]; Delta opioid receptor expression correlates to skin ageing and melanin expression in Asian women., [RefSeq, PubMed]; Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity., [UniProtKB, PubMed]; Epigenetic and sex differences in opioid use disorder in chronic pain: A real-world study linked with OPRM1 DNA methylation. Erratum:[Addict Biol. 2025;30(3):e70030. doi: 10.1111/adb.70030. PMID: 40095778], [RefSeq, PubMed]; Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:10529478, PubMed:12589820, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10529478, PubMed:10836142, PubMed:12589820, PubMed:19300905, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (By similarity). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G protein complex and subsequent exchange of GDP for GTP in the G protein alpha subunit leading to dissociation of the G protein complex with the free GTP-bound G protein alpha and the G protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (By similarity). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (By similarity). The activation of the ERK pathway occurs either in a G protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G protein-coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G protein coupling (By similarity). Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; These results indicate that re-initiation in MOR gene expression could play an important role in OPRM1 regulation., [RefSeq, PubMed]; This article summarizes the genetic variations in the human OPRM1 gene, which are analyzed with regard to pain sensitivity, opioid drug sensitivity and susceptibility to drug dependence, and other disorders.[Review] Review article, [RefSeq, PubMed]; This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]., [RefSeq]",
        "predicted_glycosites": 4,
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        "reported_n_glycosites": 1,
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        "total_reported_n_glycosites": 1,
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        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 14,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 22,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0FXJ1;B2R9S7;B8Q1L7;B8Q1L8;B8Q1L9;E7EWZ3;G8XRH6;G8XRH8;Q12930;Q4VWM1;Q4VWM2;Q4VWM3;Q4VWM4;Q4VWM6;Q4VWX6;Q5TDA1;Q6UPP1;Q6UQ80;Q7Z2D8;Q86V80;Q8IWW3;Q8IWW4;Q9UCZ4;Q9UN57",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0004930 G protein-coupled receptor activity;GO:0001965 G-protein alpha-subunit binding;GO:0005245 voltage-gated calcium channel activity;GO:0038047 morphine receptor activity",
        "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030424 axon",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0008285 negative regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 26.3,
        "record_id": "P35372-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86YD7-1",
        "uniprot_id": "F90A1_HUMAN",
        "mass": 49793.0,
        "length": 464,
        "protein_name": "Protein FAM90A1",
        "gene_name": "FAM90A1",
        "organism": "Human",
        "refseq_name": "protein FAM90A1",
        "refseq_ac": "NP_001306911",
        "gene_names_uniprotkb": "FAM90A1",
        "gene_names_refseq": "FAM90A1",
        "protein_names_uniprotkb": "Protein FAM90A1",
        "protein_names_refseq": "protein FAM90A1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55138)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;28904123;31844290;32015217;33298915;35051231",
        "class_list": "",
        "function": "FAM90A1 belongs to subfamily I of the primate-specific FAM90A gene family, which originated from multiple duplications and rearrangements (Bosch et al., 2007 [PubMed 17684299]).[supplied by OMIM, Oct 2009]., [RefSeq]; Integrated analysis of DNA methylation and mRNA expression profiles to identify key genes involved in the regrowth of clinically non-functioning pituitary adenoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
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        "reported_s_glycosites_with_glycan": 0,
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        "reported_mutagensis": 0,
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        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DUU9;Q9NVZ6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q86YD7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P16930-1",
        "uniprot_id": "FAAA_HUMAN",
        "mass": 46374.0,
        "length": 419,
        "protein_name": "Fumarylacetoacetase",
        "gene_name": "FAH",
        "organism": "Human",
        "refseq_name": "fumarylacetoacetase",
        "refseq_ac": "NP_000128",
        "gene_names_uniprotkb": "FAH",
        "gene_names_refseq": "FAH",
        "protein_names_uniprotkb": "Fumarylacetoacetase; 3.7.1.2; Beta-diketonase; FAA; Fumarylacetoacetate hydrolase",
        "protein_names_refseq": "FAA; beta-diketonase; epididymis secretory sperm binding protein; fumarylacetoacetase; fumarylacetoacetate hydrolase (fumarylacetoacetase)",
        "tax_id": 9606,
        "disease": "tyrosinemia type I (Disease Ontology:DOID:0050726); hypertension (Disease Ontology:DOID:10763); liver cirrhosis (Disease Ontology:DOID:5082)",
        "pathway": " (hsa:2184);  (R-HSA-8963684)",
        "pathway_count": 2,
        "publication_count": 73,
        "publication_id_list": "10876237;10942115;11196105;11237011;11278491;11327815;11476670;1401056;16640556;1998338;20003495;21153519;2336361;23481700;24275569;25418920;26811146;26992070;27535533;27846572;27920218;28218747;28514659;28904123;29242379;29493099;29557506;29632046;29786170;30573663;30779550;30833945;31154438;31530632;31844290;31848261;32157095;32350084;32387766;32488085;32938616;33218190;33592498;33670179;33968037;33981976;34047349;34382351;34509645;34561969;34678209;34725712;34932366;35051231;35251023;35561310;35580925;36369907;37794595;38665916;5487549;7550234;7757089;7942842;7977370;8005583;8318997;8364576;8557261;8723690;8782815;9101289;9633815",
        "class_list": "",
        "function": "E3 Ubiquitin Ligase APC/C(Cdh1) Negatively Regulates FAH Protein Stability by Promoting Its Polyubiquitination. Publication Status: Online-Only, [RefSeq, PubMed]; Fumarylacetoacetate hydrolase gene as a knockout target for hepatic chimerism and donor liver production. Review article, [RefSeq, PubMed]; Survival-Assured Liver Injury Preconditioning (SALIC) Enables Robust Expansion of Human Hepatocytes in Fah(-/-) Rag2(-/-) IL2rg(-/-) Rats., [RefSeq, PubMed]; The compound heterozygous mutations of c.607G>a and c.657delC in the FAH gene are associated with renal damage with hereditary tyrosinemia type 1 (HT1)., [RefSeq, PubMed]; Therapeutic Targeting of Fumaryl Acetoacetate Hydrolase in Hereditary Tyrosinemia Type I. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9X1;D3DW95;Q53XA7",
        "ec_number_list": "3.7.1.2",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004334 fumarylacetoacetase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process;GO:1902000 homogentisate catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.6,
        "record_id": "P16930-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86UY5-1",
        "uniprot_id": "FA83A_HUMAN",
        "mass": 47458.0,
        "length": 434,
        "protein_name": "Protein FAM83A",
        "gene_name": "FAM83A",
        "organism": "Human",
        "refseq_name": "protein FAM83A isoform c",
        "refseq_ac": "NP_001275516",
        "gene_names_uniprotkb": "FAM83A; TSGP",
        "gene_names_refseq": "BJ-TSA-9; FAM83A; SACK1A",
        "protein_names_uniprotkb": "Protein FAM83A; Tumor antigen BJ-TSA-9; Tumor-specific gene expressed in prostate protein",
        "protein_names_refseq": "family with sequence similarity 83 member A; protein FAM83A isoform c; protein FAM83A; tumor antigen BJ-TSA-9; tumor-specific gene expressed in prostate protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84985);  (R-HSA-177929)",
        "pathway_count": 2,
        "publication_count": 31,
        "publication_id_list": "16354590;1688559;18452278;18514066;18669648;18767875;19413330;2022652;22886303;23186163;23912460;24736947;2543678;25576301;27893789;29331515;29557506;31075398;32350084;32938616;35051231;35251023;35580925;36284347;36797256;37065746;37904848;38432129;38942760;8639530;8845374",
        "class_list": "",
        "function": "B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with beta-catenin. Publication Status: Online-Only, [RefSeq, PubMed]; FAM83A interacted with and caused phosphorylation of c-RAF and PI3K p85, upstream of MAPK and downstream of EGFR., [RefSeq, PubMed]; High-risk histological subtype-related FAM83A hijacked FOXM1 transcriptional regulation to promote malignant progression in lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in mitochondrial maintenance during adipogenesis. May be acting by playing a role in the maintenance of normal mitochondrial function., [UniProtKB, UniProtKB]; NcRNA-mediated upregulation of FAM83A is associated with poor prognosis and immune infiltration in pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Over-expression of BJ-TSA-9 is associated with lung cancer, [RefSeq, PubMed]; Promotion of stem cell-like phenotype of lung adenocarcinoma by FAM83A via stabilization of ErbB2. Publication Status: Online-Only, [RefSeq, PubMed]; Sense and anti-sense: Role of FAM83A and FAM83A-AS1 in Wnt, EGFR, PI3K, EMT pathways and tumor progression. Review article, [RefSeq, PubMed]; The diagnostic value of BJ-TSA-9 was explored in combination with other known lung cancer markers for the detection of circulating cancer cells in lung cancer patients., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q71HL2;Q8N7I1;Q96I47",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:1904179 positive regulation of adipose tissue development;GO:0008283 cell population proliferation;GO:0050872 white fat cell differentiation;GO:0007173 epidermal growth factor receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q86UY5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NEG0-1",
        "uniprot_id": "GAR6_HUMAN",
        "mass": 27472.0,
        "length": 241,
        "protein_name": "Golgi-associated RAB2 interactor protein 6",
        "gene_name": "GARIN6",
        "organism": "Human",
        "refseq_name": "Golgi-associated RAB2 interactor protein 6",
        "refseq_ac": "NP_699195",
        "gene_names_uniprotkb": "GARIN6; FAM71C",
        "gene_names_refseq": "FAM71C; GARIN6",
        "protein_names_uniprotkb": "Golgi-associated RAB2 interactor protein 6",
        "protein_names_refseq": "Golgi associated RAB2 interactor protein 6; Golgi-associated RAB2 interactor protein 6; family with sequence similarity 71 member C; protein FAM71C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:196472)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "25576301",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6Y6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q8NEG0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NEA9-1",
        "uniprot_id": "GMCL2_HUMAN",
        "mass": 60299.0,
        "length": 526,
        "protein_name": "Germ cell-less protein-like 2",
        "gene_name": "GMCL2",
        "organism": "Human",
        "refseq_name": "germ cell-less protein-like 2",
        "refseq_ac": "NP_001344937",
        "gene_names_uniprotkb": "GMCL2; GCL; GMCL1L; GMCL1P1",
        "gene_names_refseq": "GCL; GMCL1L; GMCL1P1; GMCL2",
        "protein_names_uniprotkb": "Germ cell-less protein-like 2; Germ cell-less protein-like 1-like",
        "protein_names_refseq": "germ cell-less protein-like 2; germ cell-less related; germ cell-less, spermatogenesis associated 2; putative germ cell-less protein-like 1-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64396)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "14528312;16201836;16959974",
        "class_list": "",
        "function": "Possible function in spermatogenesis. Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312)., [UniProtKB, PubMed, UniProtKB]; This locus shares a high degree of identity with the multi-exon germ cell-less gene on chromosome 2. Despite its single-exon nature, this chromosome 5 locus contains an open reading frame that could putatively encode a full-length germ cell-less related protein. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDW6;Q2VIQ8;Q8TC88;Q8TC89",
        "ec_number_list": "",
        "go_molecular_function": "GO:0097602 cullin family protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0016363 nuclear matrix",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0016567 protein ubiquitination;GO:0007281 germ cell development",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q8NEA9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O76083-1",
        "uniprot_id": "PDE9A_HUMAN",
        "mass": 68493.0,
        "length": 593,
        "protein_name": "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A",
        "gene_name": "PDE9A",
        "organism": "Human",
        "refseq_name": "high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform b",
        "refseq_ac": "NP_001001567",
        "gene_names_uniprotkb": "PDE9A",
        "gene_names_refseq": "HSPDE9A2; PDE9A",
        "protein_names_uniprotkb": "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; 3.1.4.35",
        "protein_names_refseq": "CGMP-specific 3',5'-cyclic phosphodiesterase type 9; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform b; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; phosphodiesterase PDE9A21",
        "tax_id": 9606,
        "disease": "Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)",
        "pathway": " (hsa:5152);  (R-HSA-418457)",
        "pathway_count": 2,
        "publication_count": 35,
        "publication_id_list": "12565835;14527714;15210993;16150925;16990611;17090334;18757755;19919087;20121115;21483814;22328573;22985069;23025719;24746902;25576301;25799991;26992070;28228285;29314611;29493099;30429286;31844290;32983136;33787083;33936100;34016083;34087483;34171305;34561969;35051231;35580925;37217939;8557689;9624146;9856478",
        "class_list": "",
        "function": "Evaluation of phosphodiesterase 9A as a novel biomarker in heart failure with preserved ejection fraction., [RefSeq, PubMed]; Identification and distribution of different variants produced by differential splicing of phosphodiesterase 9A mRNA., [RefSeq, PubMed]; Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:18757755, PubMed:21483814, PubMed:9624146). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBI5;B4DFI5;D3DSJ8;D3DSJ9;O75490;O75491;O95225;Q53Y40;Q5QD39;Q86SF7;Q86SI6;Q86SJ3;Q86WN3;Q86WN4;Q86WN5;Q86WN6;Q86WN7;Q86WN8;Q86WN9;Q86WP0",
        "ec_number_list": "3.1.4.-;3.1.4.17;3.1.4.35;3.6.1.25;3.6.1.14;3.1.4.53",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043204 perikaryon",
        "go_biological_process": "GO:0007165 signal transduction;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0010613 positive regulation of cardiac muscle hypertrophy;GO:2000178 negative regulation of neural precursor cell proliferation;GO:0046068 cGMP metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "O76083-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P05783-1",
        "uniprot_id": "K1C18_HUMAN",
        "mass": 48058.0,
        "length": 430,
        "protein_name": "Keratin, type I cytoskeletal 18",
        "gene_name": "KRT18",
        "organism": "Human",
        "refseq_name": "keratin, type I cytoskeletal 18",
        "refseq_ac": "NP_000215",
        "gene_names_uniprotkb": "KRT18; CYK18; PIG46",
        "gene_names_refseq": "CK-18; CYK18; K18; KRT18",
        "protein_names_uniprotkb": "Keratin, type I cytoskeletal 18; CK-18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; K18; Keratin-18",
        "protein_names_refseq": "cell proliferation-inducing gene 46 protein; cytokeratin 18; keratin 18, type I; keratin, type I cytoskeletal 18",
        "tax_id": 9606,
        "disease": "primary sclerosing cholangitis (Disease Ontology:DOID:0060643); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); primary biliary cholangitis (Disease Ontology:DOID:12236); liver disease (Disease Ontology:DOID:409); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); cirrhosis, familial (MONDO:MONDO:0007329)",
        "pathway": " (hsa:3875);  (R-HSA-6805567);  (R-HSA-6809371);  (R-HSA-9927418);  (R-HSA-9927426)",
        "pathway_count": 5,
        "publication_count": 201,
        "publication_id_list": "10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10066784;10196183;10231017;10411887;10588656;10771479;10809736;10852826;10954706;11237011;11350120;11380615;11590230;11684708;12724528;12902340;1371281;1374067;14756564;15004565;15033990;15337775;15368451;15373777;15529338;15731013;15797384;15803139;15846844;16061697;16134083;16382671;16424149;16639001;1691188;1694855;17081983;17084817;1714783;17213200;17515931;17521629;17562024;17596512;17924679;18083107;18369606;18452278;18669648;18691976;18843291;19007248;19190773;19194479;19415658;19608861;19615748;19651622;19664994;19664995;20068230;20068231;20166139;20179351;20657595;20667819;20724476;20729549;20729838;20940292;21439340;21654840;21997417;22002106;22121020;22967762;23186163;23481192;23576270;23629652;23902688;24126823;24129315;2414304;2422083;24275569;2434380;2434381;2454392;24940650;25114211;25208914;25576301;25645385;25813380;25926655;25992863;26390218;26823019;26853435;26992070;27059955;27397612;27862975;28510447;28834231;29237092;29242379;29314611;29371260;29393594;29557506;29632711;29741879;29786170;29789417;30059200;30192525;30379171;30429286;30484775;30524438;30620550;30779550;30833945;30929300;31154438;31373491;31492838;31611695;31637018;31844290;31848261;32157095;32161166;32350084;32373127;32387766;32488085;32574038;32632966;32897882;32938616;33123756;33214551;33537174;33836029;33912179;33968037;33981976;34019948;34087483;34105348;34171305;34185709;34405274;34509645;35051231;35083852;35132862;35254053;35289036;35485207;35513511;35561310;35580925;36010968;36215666;36241641;36284347;36375525;36441143;36580660;37074911;37340703;37509164;37938771;38665916;39302247;39531497;39534244;40136647;40596516;41350704;7523419;7538124;7543090;8522591;8609167;8824274;8999895;9011570;9079710;9150948;9298992;9395522;9468612;9524113;9565599",
        "class_list": "",
        "function": "A new detection system for serum fragmented cytokeratin 18 as a biomarker reflecting histologic activities of human nonalcoholic steatohepatitis., [RefSeq, PubMed]; Circulating caspase-cleaved cytokeratin 18 correlates with tumour burden and response to therapy in patients with colorectal cancer liver metastasis., [RefSeq, PubMed]; KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Markers of cell death predict therapy response in patients with cirrhosis and hepatorenal syndrome., [RefSeq, PubMed]; Serum Level of Cytokeratin 18 (M65) as a Prognostic Marker of High Cardiovascular Disease Risk in Individuals with Non-Alcoholic Fatty Liver Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of intermediate filaments in simple epithelial cells. Forms obligate heteropolymers with a type II keratin KRT8, mechanical stability and resilience to epithelial cells (PubMed:15529338, PubMed:26823019). KRT8/KRT18 filaments are involved in ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (PubMed:26823019). Organization and orientation of KRT8/KRT18 filaments are responsible for the properly elongated morphology of epithelial tubules (By similarity). Also acts downstream of ROCK kinase activation as part of a positive feedback mechanism in response to cellular mechanical stress loading (PubMed:26823019). Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization (PubMed:7523419, PubMed:8522591, PubMed:9298992, PubMed:9524113). Involved in the delivery of mutated CFTR to the plasma membrane (PubMed:15529338, PubMed:16424149). Involved in interleukin-6 (IL-6)-mediated barrier protection (PubMed:17213200)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 3,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 19,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 19,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 19,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 43,
        "reported_mutagensis": 20,
        "reported_glycation": 0,
        "reported_snv": 39,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "diagnostic",
        "glycan_count": 6,
        "disease_count": 8,
        "glyco_site_count": 21,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53G38;Q5U0N8;Q9BW26",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005198 structural molecule activity;GO:0097110 scaffold protein binding;GO:0098641 cadherin binding involved in cell-cell adhesion",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005912 adherens junction",
        "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0043001 Golgi to plasma membrane protein transport;GO:0045104 intermediate filament cytoskeleton organization;GO:0009653 anatomical structure morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 22.9,
        "record_id": "P05783-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P45983-1",
        "uniprot_id": "MK08_HUMAN",
        "mass": 48296.0,
        "length": 427,
        "protein_name": "Mitogen-activated protein kinase 8",
        "gene_name": "MAPK8",
        "organism": "Human",
        "refseq_name": "mitogen-activated protein kinase 8 isoform beta2",
        "refseq_ac": "NP_001265476",
        "gene_names_uniprotkb": "MAPK8; JNK1; PRKM8; SAPK1C; SAPK1",
        "gene_names_refseq": "JNK-46; JNK1A2; JNK1; JNK21B1/2; JNK; MAPK8; PRKM8; SAPK1c; SAPK1",
        "protein_names_uniprotkb": "Mitogen-activated protein kinase 8; 2.7.11.24; JNK-46; MAP kinase 8; MAPK 8; SAPK1c; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1",
        "protein_names_refseq": "JUN N-terminal kinase; MAP kinase 8; c-Jun N-terminal kinase 1; mitogen-activated protein kinase 8 isoform beta2; stress-activated protein kinase 1c; stress-activated protein kinase 1",
        "tax_id": 9606,
        "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stroke (Disease Ontology:DOID:0051061); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); rectal benign neoplasm (Disease Ontology:DOID:1984); chronic mucocutaneous candidiasis (Disease Ontology:DOID:2058); brain ischemia (Disease Ontology:DOID:2316); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:5599);  (R-HSA-111446);  (R-HSA-139910);  (R-HSA-193648);  (R-HSA-205043);  (R-HSA-2559580);  (R-HSA-2871796);  (R-HSA-450321);  (R-HSA-450341);  (R-HSA-5693565);  (R-HSA-9007892);  (R-HSA-9673324);  (R-HSA-9725370)",
        "pathway_count": 13,
        "publication_count": 457,
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        "class_list": "",
        "function": "DUSP4 maintains the survival and LSD1 protein stability in esophageal squamous cell carcinoma cells by inhibiting JNK signaling-dependent autophagy., [RefSeq, PubMed]; JNK promotes the progression of castration-resistant prostate cancer., [RefSeq, PubMed]; JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms., [UniProtKB]; MicroRNA miR-181d-5p regulates the MAPK signaling pathway by targeting mitogen-activated protein kinase 8 (MAPK8) to improve lupus nephritis., [RefSeq, PubMed]; Progestins and breast cancer hallmarks: The role of the ERK1/2 and JNK pathways in estrogen receptor positive breast cancer cells., [RefSeq, PubMed]; Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity., [UniProtKB, UniProtKB, UniProtKB]; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway (PubMed:28943315). In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity (PubMed:18307971). Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins (PubMed:21856198). Loss of this interaction abrogates the acetylation required for replication initiation (PubMed:21856198). Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1 (PubMed:21364637). In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation (PubMed:21095239). Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy (PubMed:18570871). Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons (By similarity). In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone (By similarity). Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH (PubMed:16581800, PubMed:17296730, PubMed:20027304). Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly (PubMed:22966201). Phosphorylates SIRT6 in response to oxidative stress, stimulating its mono-ADP-ribosyltransferase activity (PubMed:27568560). Phosphorylates NLRP3, promoting assembly of the NLRP3 inflammasome (PubMed:28943315). Phosphorylates ALKBH5 in response to reactive oxygen species (ROS), promoting ALKBH5 sumoylation and inactivation (PubMed:34048572)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 19,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 19,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5BTZ5;B7ZLV4;D3DX88;D3DX92;Q15709;Q15712;Q15713;Q308M2",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;3.1.-.-;2.7.11.31;3.6.5.2;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;3.2.2.6;2.7.1.150",
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042826 histone deacetylase binding;GO:0019903 protein phosphatase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon",
        "go_biological_process": "GO:0007258 JUN phosphorylation;GO:0006468 protein phosphorylation;GO:0006979 response to oxidative stress;GO:0010628 positive regulation of gene expression;GO:0043065 positive regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 45.8,
        "record_id": "P45983-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z4S6-1",
        "uniprot_id": "KI21A_HUMAN",
        "mass": 187179.0,
        "length": 1674,
        "protein_name": "Kinesin-like protein KIF21A",
        "gene_name": "KIF21A",
        "organism": "Human",
        "refseq_name": "kinesin-like protein KIF21A isoform 3",
        "refseq_ac": "NP_001166934",
        "gene_names_uniprotkb": "KIF21A; KIAA1708; KIF2",
        "gene_names_refseq": "CFEOM1; FEOM1; FEOM3A; KIF21A",
        "protein_names_uniprotkb": "Kinesin-like protein KIF21A; Kinesin-like protein KIF2; Renal carcinoma antigen NY-REN-62",
        "protein_names_refseq": "kinesin-like protein KIF21A isoform 3; kinesin-like protein KIF2; renal carcinoma antigen NY-REN-62",
        "tax_id": 9606,
        "disease": "congenital fibrosis of the extraocular muscles (Disease Ontology:DOID:0080143); congenital fibrosis of the extraocular muscles 1 (Disease Ontology:DOID:0081015)",
        "pathway": " (hsa:55605);  (R-HSA-6811434);  (R-HSA-983189)",
        "pathway_count": 3,
        "publication_count": 196,
        "publication_id_list": "10052452;10318838;10445031;10508479;10559959;10761932;10921873;11172815;11237011;11493604;11689559;11703931;11726511;11739780;11748249;11782313;12047556;12070132;12368902;12702216;1406973;14504276;14595441;14654841;15029241;15037235;15272311;15326200;15616190;15632110;15813748;16030262;1607388;16157808;16262723;1631136;16571679;16633337;1680566;16912714;16926190;16940185;17081983;17113389;17253781;17346968;17360540;17429068;17451557;17511870;17538014;17760859;17927562;17956946;18160138;18182008;18287528;18332320;18342609;18524849;18669648;18809720;1898986;19015319;19109418;19116309;19151722;19164740;19338388;19369418;1957170;19631211;19758564;20005805;20068231;20136777;20357002;20427317;20462495;20534429;20637885;21219331;21406692;2142332;21550981;21689688;21844168;22013193;22094269;22223895;22304919;22424782;23186163;23396477;23481700;24120883;24275569;24366607;24714562;24715754;2521221;2522352;25364732;25418920;25436559;25492864;25576301;25645385;25892735;26375851;26758079;26811146;26992070;27846572;27920218;28063628;28228285;28352266;28514659;28649982;28832583;28834231;28904123;29183992;29242379;29393594;29508533;29557506;29632046;29632711;29769354;29786170;30192525;30315122;30410026;30484775;30833945;31154438;31217245;3130248;3134048;31530632;31844290;31848261;32157095;32350084;32357974;32387766;32502341;32938616;32983136;33298915;33717175;33936100;33968037;33981976;34087483;34171305;34274317;34698969;34740919;34932366;35051231;35154160;35280030;35318648;35561310;35580925;36010968;36284347;36581221;37217939;37921537;37938771;7528108;7539720;7822426;7844144;7929562;8001155;8128252;8132710;8221884;8253837;8505331;8548803;8599929;8602245;8620540;9114004;9177194;9244307;9288971;9405360;9751720;9990005",
        "class_list": "",
        "function": "Bi-allelic loss-of-function variants in KIF21A cause severe fetal akinesia with arthrogryposis multiplex., [RefSeq, PubMed]; KIF21A regulates breast cancer aggressiveness and is prognostic of patient survival and tumor recurrence., [RefSeq, PubMed]; Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A., [RefSeq, PubMed]; Phenotypic heterogeneity associated with KIF21A: Two new cases and review of the literature. Review article, [RefSeq, PubMed]; Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Surgery is effective at improving ptosis in the majority of patients with classic CFEOM (congenital fibiosis of the extraocular muscles). Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]., [RefSeq]; [Identification of a novel KIF21A gene mutation in a Chinese family with congenital fibrosis of the extraocular muscles]., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 39,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MX28;B0I1R9;B9EGE4;F5H0C3;F5H219;Q2UVF1;Q6UKL9;Q7Z668;Q86WZ5;Q8IVZ8;Q9C0F5;Q9NXU4;Q9Y590",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0008574 plus-end-directed microtubule motor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005938 cell cortex;GO:0030425 dendrite;GO:0005871 kinesin complex",
        "go_biological_process": "GO:1902667 regulation of axon guidance;GO:0031113 regulation of microtubule polymerization;GO:0007018 microtubule-based movement;GO:0008089 anterograde axonal transport;GO:0043622 cortical microtubule organization",
        "synthesized_glycan_count": 0,
        "hit_score": 19.9,
        "record_id": "Q7Z4S6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99593-1",
        "uniprot_id": "TBX5_HUMAN",
        "mass": 57711.0,
        "length": 518,
        "protein_name": "T-box transcription factor TBX5",
        "gene_name": "TBX5",
        "organism": "Human",
        "refseq_name": "T-box transcription factor TBX5 isoform 1",
        "refseq_ac": "NP_000183",
        "gene_names_uniprotkb": "TBX5",
        "gene_names_refseq": "HOS; TBX5",
        "protein_names_uniprotkb": "T-box transcription factor TBX5; T-box protein 5",
        "protein_names_refseq": "T-box 5; T-box protein 5; T-box transcription factor TBX5 isoform 1; T-box transcription factor TBX5",
        "tax_id": 9606,
        "disease": "Holt-Oram syndrome (Disease Ontology:DOID:0060468); myocardial infarction (Disease Ontology:DOID:5844); retinal degeneration (Disease Ontology:DOID:8466)",
        "pathway": " (hsa:6910);  (R-HSA-2032785);  (R-HSA-5578768);  (R-HSA-9733709)",
        "pathway_count": 4,
        "publication_count": 50,
        "publication_id_list": "10077612;10587520;10842287;10880574;11183182;12818525;14559895;15095414;15146390;15735645;16332960;1672777;17660514;18579750;19324876;19324877;19479054;19934029;20110263;20450920;2144260;24000169;25187301;25202235;25576301;25725155;25963046;26783251;26817948;26917986;26926761;26990595;27035640;27846572;29174768;29636455;31844290;32506827;33054971;35051231;37393232;37926287;38336121;38525280;38735135;39894887;8988164;8988165;9584153;9651244",
        "class_list": "",
        "function": "CircTBX5 knockdown modulates the miR-558/MyD88 axis to alleviate IL-1beta-induced inflammation, apoptosis and extracellular matrix degradation in chondrocytes via inactivating the NF-kappaB signaling. Publication Status: Online-Only, [RefSeq, PubMed]; DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:25725155, PubMed:25963046, PubMed:26917986, PubMed:27035640, PubMed:29174768, PubMed:8988164). Binds to the core DNA motif of NPPA promoter (PubMed:26926761)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Overexpression of transcription factor TBX5 inhibits the activation of YAP1-TEAD1 pathway to promote ferroptosis in lung cancer cells., [RefSeq, PubMed]; Prioritizing cardiovascular disease-associated variants altering NKX2-5 and TBX5 binding through an integrative computational approach., [RefSeq, PubMed]; TBX5 genetic variants and SCD-CAD susceptibility: insights from Chinese Han cohorts. Publication Status: Online-Only, [RefSeq, PubMed]; TBX5 variants and cardiac phenotype: A systematic review of the literature and a novel variant., [RefSeq, PubMed]; This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6ND77;O15301;Q96TB0;Q9Y4I2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0001708 cell fate specification;GO:0003166 bundle of His development;GO:0060929 atrioventricular node cell fate commitment;GO:0060980 cell migration involved in coronary vasculogenesis;GO:0051891 positive regulation of cardioblast differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q99593-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96ES7-1",
        "uniprot_id": "SGF29_HUMAN",
        "mass": 33238.0,
        "length": 293,
        "protein_name": "SAGA-associated factor 29",
        "gene_name": "SGF29",
        "organism": "Human",
        "refseq_name": "SAGA-associated factor 29",
        "refseq_ac": "NP_612423",
        "gene_names_uniprotkb": "SGF29; CCDC101",
        "gene_names_refseq": "CCDC101; SGF29; STAF36; TDRD29",
        "protein_names_uniprotkb": "SAGA-associated factor 29; Coiled-coil domain-containing protein 101; SAGA complex-associated factor 29",
        "protein_names_refseq": "SAGA-associated factor 29 homolog; SAGA-associated factor 29; coiled-coil domain containing 101; coiled-coil domain-containing protein 101",
        "tax_id": 9606,
        "disease": "diabetic retinopathy (Disease Ontology:DOID:8947)",
        "pathway": " (hsa:112869);  (R-HSA-3214847);  (R-HSA-9772755)",
        "pathway_count": 3,
        "publication_count": 126,
        "publication_id_list": "10786633;10821277;11237011;12393701;12482972;12670868;14636557;14992727;15199122;15313887;16227571;16239140;16387653;16829959;16878130;16892064;17355966;17500065;17612494;17671196;17925232;17998332;18381289;18598942;18623064;18829457;18829459;18838386;18838538;19103755;19124460;19187761;19187765;19556245;19608861;20018852;20068231;20575550;20716525;20850016;20961854;21106533;21124902;21131905;21135039;21220120;21685874;22266653;22327296;22652693;22665483;23508102;23894581;23995757;24244196;24368734;24680668;24714562;24715725;25418920;25561738;25576301;25593305;26324722;26375851;26421618;26578293;26886794;26992070;27563068;27698142;27760318;27846572;27862975;28182322;28218747;28398509;28832583;28834231;28904123;29138278;29242379;29437277;29493099;29557506;29632711;29786170;29897600;29937342;30379171;30429286;31400120;31485071;31544921;31844290;32157095;32161166;32357974;32387766;32897882;32938616;33298915;33657400;33691108;33717175;33912179;33936100;33968037;34012049;34019948;34087483;34171305;34211107;34509645;34933446;35033534;35051231;35190547;35254053;35439434;35580925;38048593;40596516;9427644;9558366;9880483",
        "class_list": "",
        "function": "CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]., [RefSeq]; Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506' (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Transcriptional control of leukemogenesis by the chromatin reader SGF29., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 22,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96MF5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0140034 methylation-dependent protein binding;GO:0140002 histone H3K4me3 reader activity;GO:0140003 histone H3K36me3 reader activity",
        "go_cellular_component": "GO:0070461 SAGA-type complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000124 SAGA complex;GO:0072686 mitotic spindle",
        "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 12.9,
        "record_id": "Q96ES7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60264-1",
        "uniprot_id": "SMCA5_HUMAN",
        "mass": 121905.0,
        "length": 1052,
        "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5",
        "gene_name": "SMARCA5",
        "organism": "Human",
        "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5",
        "refseq_ac": "NP_003592",
        "gene_names_uniprotkb": "SMARCA5; SNF2H; WCRF135",
        "gene_names_refseq": "ISWI; SMARCA5; SNF2H; WCRF135; hISWI; hSNF2H",
        "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; 3.6.4.-; SMARCA5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; Sucrose nonfermenting protein 2 homolog; hSNF2H",
        "protein_names_refseq": "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; sucrose nonfermenting protein 2 homolog; sucrose nonfermenting-like 5",
        "tax_id": 9606,
        "disease": "central nervous system disease (Disease Ontology:DOID:331)",
        "pathway": " (hsa:8467);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5693565);  (R-HSA-606279)",
        "pathway_count": 5,
        "publication_count": 221,
        "publication_id_list": "10.1101/2023.09.13.557529;10471499;10550055;10655480;10724175;10766245;10802669;10866324;10880450;10914549;10959836;10973490;11025670;11114888;11390408;11435432;11571274;11573085;11875071;11893489;11927591;11934988;11980720;12198550;12364621;12434153;12447390;12485996;12607003;12607005;12697768;12773400;12792649;12832489;12890688;12972596;14560035;14610093;14759371;15064416;15104674;15201865;15279782;15284901;15369671;15543136;15558034;16150728;16377563;16427009;16514417;16603771;16622420;16651405;17081983;17199038;17339379;17355984;17525332;17525340;17553757;17693683;17848578;18001824;18001825;18006705;18077395;18443292;18644861;18669648;18691976;19001859;19092802;19117993;19176521;19203578;19203579;19234442;19261749;19351884;19398759;19410544;19410545;19608861;19690332;19782031;19838300;20016603;20023648;20068231;20080577;20351172;20566683;21282113;21293379;21406692;21559432;21768289;22234877;22373579;22508508;22589545;22908299;22980979;23186163;23481700;23555303;23667505;23911928;24275569;24366607;24397554;24667604;24714562;24715725;24901984;24952918;25418920;25469497;25576301;25645385;25880248;25892735;25916849;26100909;26154972;26375851;26768311;26811146;26992070;27397612;27600516;27846572;27862975;27869121;27920218;28063628;28218747;28228285;28510447;28514659;28801535;28832583;28834231;28904123;29242379;29393594;29437277;29485866;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30379171;30410026;30429286;30779550;30833945;31154438;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32522876;32897882;32938616;32983136;33091337;33123756;33141586;33214551;33298915;33537174;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34185709;34211107;34357683;34509645;34725712;34932366;35051231;35251023;35580925;36010968;36241641;36284347;36581221;36872061;37155876;37625840;38665916;38776924;40307207;40914422;7597036;8944023;9168116;9488723;9730600",
        "class_list": "",
        "function": "ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Circular RNA SMARCA5 Promotes a Poor Prognosis and Radiotherapy Resistance for Patients with Hepatocellular Carcinoma., [RefSeq, PubMed]; Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes., [RefSeq, PubMed]; SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis., [RefSeq, PubMed]; The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation and homologous recombination repair., [RefSeq, PubMed]; The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;2.7.7.6;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;2.1.1.37;3.4.21.53;5.6.2.5;2.7.11.1;2.7.11.26;2.7.11.24;3.1.-.-;3.6.5.-;7.6.2.1;2.3.1.48;2.3.1.-;3.5.1.-;3.5.1.98;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;3.6.1.15;3.1.4.-;2.3.1.57;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.10.2;2.7.4.3",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0000793 condensed chromosome",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 22.6,
        "record_id": "O60264-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q02086-1",
        "uniprot_id": "SP2_HUMAN",
        "mass": 64900.0,
        "length": 613,
        "protein_name": "Transcription factor Sp2",
        "gene_name": "SP2",
        "organism": "Human",
        "refseq_name": "transcription factor Sp2",
        "refseq_ac": "NP_003101",
        "gene_names_uniprotkb": "SP2; KIAA0048",
        "gene_names_refseq": "SP2",
        "protein_names_uniprotkb": "Transcription factor Sp2",
        "protein_names_refseq": "transcription factor Sp2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6668)",
        "pathway_count": 1,
        "publication_count": 63,
        "publication_id_list": "11237011;1341900;18669648;19413330;20068231;21606357;23186163;23481700;24714562;24715725;25576301;26154972;26992070;27846572;27862975;28832583;28904123;29242379;29351928;29393594;29493099;29557506;29632046;29632711;29786170;30059200;30315122;30379171;30620550;31154438;31375868;31492838;31844290;31848261;31998317;32157095;32265295;32502341;32574038;32938616;32938750;32983136;33298915;33592498;33968037;33981976;34087483;34687796;34914964;35051231;35132862;35254053;35580925;36010968;36215666;36241641;36284347;37541260;37938771;39302247;39531497;40307207;40596516",
        "class_list": "",
        "function": "Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites., [UniProtKB]; This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription Factor SP2 Regulates Ski-mediated Astrocyte Proliferation In Vitro., [RefSeq, PubMed]; Transcription factor Sp2 promotes TGFB-mediated interstitial cell osteogenic differentiation in bicuspid aortic valves through a SMAD-dependent pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NK74",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006955 immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q02086-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14776-1",
        "uniprot_id": "TCRG1_HUMAN",
        "mass": 123901.0,
        "length": 1098,
        "protein_name": "Transcription elongation regulator 1",
        "gene_name": "TCERG1",
        "organism": "Human",
        "refseq_name": "transcription elongation regulator 1 isoform 2",
        "refseq_ac": "NP_001035095",
        "gene_names_uniprotkb": "TCERG1; CA150; TAF2S",
        "gene_names_refseq": "CA150; TAF2S; TCERG1; Urn1",
        "protein_names_uniprotkb": "Transcription elongation regulator 1; TATA box-binding protein-associated factor 2S; Transcription factor CA150",
        "protein_names_refseq": "TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD; TATA box-binding protein-associated factor 2S; co-activator of 150 kDa; transcription elongation regulator 1 isoform 2; transcription factor CA150",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10915);  (R-HSA-72163);  (R-HSA-9770562)",
        "pathway_count": 3,
        "publication_count": 192,
        "publication_id_list": "10669729;10882114;10908677;11014198;11060040;11101529;11172033;11233976;11237011;11604498;11991638;12176931;12411573;12414731;12477934;14625303;14713954;14749727;15037765;15485897;15565158;16314458;16809785;17060612;17095540;17128255;17332742;17606899;17924679;18288197;18322460;18452278;18593880;19103666;19165350;19217410;19536130;20068231;20305658;20423332;20695905;20980672;21295486;21536652;21740066;2176635;22110043;22365833;22645359;22813749;22959432;22961380;23186163;23222130;23236153;23345524;23481700;23874216;24076191;24129315;24149845;24196718;24304693;24448447;24715725;24737827;24914973;25218447;25301780;25301781;25555158;25576301;2558966;25645385;25755297;25772364;25880248;26154972;26264132;26375851;26385511;26420826;26462236;26873599;26969736;26992070;27377154;27459055;27600516;27683217;27844289;27846572;27920218;28062851;28063628;28076346;28096519;28502770;28781166;28832583;28834231;28904123;28911096;29186539;29242379;29274231;29301961;29360106;29361316;29393594;29493099;29508533;29557506;29632046;2963332;29769354;29786170;30139799;30257008;30315122;30315277;30379171;30397120;30429286;30705154;30728453;30765414;30975767;31409651;31636114;31844290;32119511;32157095;32179686;32265295;32329775;32350084;32357974;32387766;32488085;32494006;32502341;32522876;32816001;32938616;32983136;33141586;33214551;33243851;33298915;33446560;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34301950;34725712;34822310;34932366;35008409;35051231;35177536;35251023;35385551;35580925;36010968;36241641;36284347;37217939;3757028;38665916;40914422;8566756;8608946;9016565;9242493;9315662;9512519;9524131;9539711;9659921;9671485;9701291;9731529",
        "class_list": "",
        "function": "Results of this study suggest that TCERG1 plays an important role in Cajal body formation and snRNP biogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; TCERG1 affects expression of multiple mRNAs involved in neuron projection development., [RefSeq, PubMed]; TCERG1 binds independently to elongation and splicing complexes, thus performing their coupling by transient interactions rather than by stable association with one or the other complexes., [RefSeq, PubMed]; TCERG1 sensitizes a cell to apoptotic agents, thus promoting apoptosis by regulating the alternative splicing of both the Bcl-x and Fas/CD95 genes. Publication Status: Online-Only, [RefSeq, PubMed]; The QA repeat domain of TCERG1 is required for relocalization of CEBPalpha., [RefSeq, PubMed]; This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2NKN2;Q59EA1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity;GO:0070063 RNA polymerase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008380 RNA splicing",
        "synthesized_glycan_count": 0,
        "hit_score": 19.5,
        "record_id": "O14776-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6H8Y1-1",
        "uniprot_id": "BDP1_HUMAN",
        "mass": 293885.0,
        "length": 2624,
        "protein_name": "Transcription factor TFIIIB component B'' homolog",
        "gene_name": "BDP1",
        "organism": "Human",
        "refseq_name": "transcription factor TFIIIB component B'' homolog",
        "refseq_ac": "NP_060899",
        "gene_names_uniprotkb": "BDP1; KIAA1241; KIAA1689; TFNR",
        "gene_names_refseq": "BDP1; DFNB112; HSA238520; TAF3B1; TFC5; TFIIIB''; TFIIIB150; TFIIIB90; TFNR",
        "protein_names_uniprotkb": "Transcription factor TFIIIB component B'' homolog; TFIIIB150; Transcription factor IIIB 150; Transcription factor-like nuclear regulator",
        "protein_names_refseq": "B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB; RNA polymerase III transcription initiation factor B''; TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1; transcription factor IIIB 150; transcription factor TFIIIB component B'' homolog; transcription factor-like nuclear regulator",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness 112 (Disease Ontology:DOID:0111637)",
        "pathway": " (hsa:55814);  (R-HSA-749476);  (R-HSA-76061);  (R-HSA-76066);  (R-HSA-76071)",
        "pathway_count": 5,
        "publication_count": 76,
        "publication_id_list": "40667337;10421633;11040218;11056176;11121026;11161782;11237011;11419933;11463379;12381659;14592981;15096501;15469824;15777939;16542149;16769183;16956891;17525332;18669648;1946469;20068231;2404611;24312468;24366607;24715725;26992070;27600516;27846572;28743884;28832583;28834231;28904123;29242379;29393594;29508533;29557506;30379171;30429286;30779550;30833945;31154438;31530632;31844290;31848261;32157095;32161166;32265295;32387766;32488085;32502341;32504003;32853945;32938616;33592498;33691108;33912179;33936100;33968037;34171305;34185709;34932366;35051231;35580925;36284347;37217939;37938771;7568218;7891697;7995525;8407894;8423814;9003788;9171375;9234698;9312031;9418884",
        "class_list": "",
        "function": "DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter. Publication Status: Online-Only, [RefSeq, PubMed]; General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site., [UniProtKB, PubMed]; Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss. Publication Status: Online-Only, [RefSeq, PubMed]; Somatic mutations of cancer-related genes PELP1 and BDP1 in colorectal cancers., [RefSeq, PubMed]; The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 55,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q68DS6;Q68DY5;Q6MZL9;Q6PIM7;Q86W98;Q96LR8;Q9C0H4;Q9H197;Q9H1A1;Q9HAW1;Q9HAW2;Q9HCY0;Q9ULH9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001156 TFIIIC-class transcription factor complex binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000126 transcription factor TFIIIB complex",
        "go_biological_process": "GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0070898 RNA polymerase III preinitiation complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "A6H8Y1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86TG1-1",
        "uniprot_id": "T150A_HUMAN",
        "mass": 28835.0,
        "length": 271,
        "protein_name": "Transmembrane protein 150A",
        "gene_name": "TMEM150A",
        "organism": "Human",
        "refseq_name": "transmembrane protein 150A isoform 1 precursor",
        "refseq_ac": "NP_001026908",
        "gene_names_uniprotkb": "TMEM150A; TMEM150",
        "gene_names_refseq": "DRAM5; TM6P1; TMEM150A; TMEM150; TTN1",
        "protein_names_uniprotkb": "Transmembrane protein 150A; Transmembrane protein 150",
        "protein_names_refseq": "fasting-inducible integral membrane protein TM6P1; tentonin 1; transmembrane protein 150A isoform 1 precursor; transmembrane protein 150",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:129303)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;25608530;26992070;31844290;32387766;32938616;33141586;35051231;38055673",
        "class_list": "",
        "function": "Overexpression of TMEM150A in glioblastoma multiforme patients correlated with dismal prognoses and compromised immune statuses. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex (PubMed:25608530). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530). May also play a role in fasting-induced catabolism (By similarity)., [UniProtKB, PubMed, UniProtKB]; TMEM150A is a functional homologue of Sfk1 in mammalian cells and plays a role in the homeostatic regulation of PI(4,5)P2 at the plasma membrane., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K764;B7WPQ9;D6W5L2;Q8N2R6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0046854 phosphatidylinositol phosphate biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q86TG1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PIV2-1",
        "uniprot_id": "FOXR1_HUMAN",
        "mass": 33310.0,
        "length": 292,
        "protein_name": "Forkhead box protein R1",
        "gene_name": "FOXR1",
        "organism": "Human",
        "refseq_name": "forkhead box protein R1",
        "refseq_ac": "NP_859072",
        "gene_names_uniprotkb": "FOXR1; DLNB13; FOXN5",
        "gene_names_refseq": "DLNB13; FOXN5; FOXR1",
        "protein_names_uniprotkb": "Forkhead box protein R1; Forkhead box protein N5",
        "protein_names_refseq": "forkhead box protein N5; forkhead box protein R1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283150)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;21860421;25609838;27284737;30379171;34723967",
        "class_list": "",
        "function": "FOXR1 expression is activated by chromosome 11q23 aberrations in B-cell lymphoma. Publication Status: Online-Only, [RefSeq, PubMed]; FOXR1 is recurrently activated in neuroblastoma by intrachromosomal deletion/fusion events, resulting in overexpression of fusion transcripts, [RefSeq, PubMed]; FOXR1 regulates stress response pathways and is necessary for proper brain development. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor which acts as both an activator and a repressor (PubMed:34723967). Activates transcription of a number of genes including the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 which are involved in protection against oxidative stress (PubMed:34723967). Required for normal brain development (By similarity)., [UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0YJ15;Q08AS8;Q86UT9;Q8IXX2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q6PIV2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P17861-1",
        "uniprot_id": "XBP1_HUMAN",
        "mass": 28695.0,
        "length": 261,
        "protein_name": "X-box-binding protein 1",
        "gene_name": "XBP1",
        "organism": "Human",
        "refseq_name": "X-box-binding protein 1 isoform XBP1(S)",
        "refseq_ac": "NP_001073007",
        "gene_names_uniprotkb": "XBP1; TREB5; XBP2",
        "gene_names_refseq": "TREB-5; TREB5; XBP-1; XBP1; XBP2",
        "protein_names_uniprotkb": "X-box-binding protein 1; TREB-5; Tax-responsive element-binding protein 5; XBP-1",
        "protein_names_refseq": "X-box-binding protein 1 isoform XBP1(S); tax-responsive element-binding protein 5",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); borna disease (Disease Ontology:DOID:5154); major affective disorder 7 (MONDO:MONDO:0012881)",
        "pathway": " (hsa:7494)",
        "pathway_count": 1,
        "publication_count": 66,
        "publication_id_list": "10375612;11237011;11460154;11779464;12949534;15466483;16461360;16959974;17110785;17224074;17765680;18477386;1903538;19380033;19394296;19413330;19416856;19622636;20348923;20955178;21233347;21892182;2196176;23184933;23186163;2321018;23529610;23560553;24715725;25190803;25239945;25280941;25448679;25576301;28228285;28649982;28832583;29242379;29786170;30429286;30833945;31154438;31530632;32157095;32387766;32938616;32983136;33298915;33968037;33981976;34087483;34171305;34509645;35318648;35580925;35874702;36010968;38648902;38688649;38861804;38871246;38967361;41417911;8349596;8627152;8657566",
        "class_list": "",
        "function": "CircPDIA3/miR-449a/XBP1 feedback loop curbs pyroptosis by inhibiting palmitoylation of the GSDME-C domain to induce chemoresistance of colorectal cancer., [RefSeq, PubMed]; Correlation Between Low Cytoplasmic Expression of XBP1 and the Likelihood of Surviving Hepatocellular Carcinoma., [RefSeq, PubMed]; Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610). Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933). Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Also improves glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803). Binds to the BECN1 gene promoter region (PubMed:23184933). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the 5'-CCACG-3' motif in the PPARG promoter (By similarity). Binds to the HEPN1 gene promoter region and activates transcription (PubMed:25448679)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Also functions as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Overactivation of XBP1 in plasma cells implies worse survival through innate immunity in esophageal squamous cell carcinoma., [RefSeq, PubMed]; Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production (PubMed:19394296, PubMed:21233347). In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (PubMed:23529610). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16461360, PubMed:25239945). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor (PubMed:8657566). Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress (PubMed:25190803). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences (PubMed:8657566). Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) (PubMed:1903538, PubMed:2196176, PubMed:2321018, PubMed:8657566). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner (PubMed:25190803). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The IRE1alpha-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection., [RefSeq, PubMed]; This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]., [RefSeq]; X-Box binding protein 1 downregulates SIRT6 to promote injury in pancreatic ductal epithelial cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WYK6;Q969P1;Q96BD7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0002020 protease binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol",
        "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:2000347 positive regulation of hepatocyte proliferation;GO:0031670 cellular response to nutrient;GO:1901985 positive regulation of protein acetylation;GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "P17861-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P5X5-1",
        "uniprot_id": "CV039_HUMAN",
        "mass": 12540.0,
        "length": 105,
        "protein_name": "Synaptic plasticity regulator PANTS",
        "gene_name": "C22orf39",
        "organism": "Human",
        "refseq_name": "synaptic plasticity regulator PANTS isoform 2",
        "refseq_ac": "NP_001159714",
        "gene_names_uniprotkb": "C22orf39",
        "gene_names_refseq": "C22orf39; Pants",
        "protein_names_uniprotkb": "Synaptic plasticity regulator PANTS; Plasticity-associated neural transcript short",
        "protein_names_refseq": "Plasticity Associated Neural Transcript; UPF0545 protein C22orf39; synaptic plasticity regulator PANTS isoform 2; synaptic plasticity regulator PANTS",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:128977)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;18477386;27920218;28063628;29393594;29632046",
        "class_list": "",
        "function": "Negatively regulates long-term potentiation and modulates adult synaptic plasticity. Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites. Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "secondary_ac_list": "A0A075B6P1;A8MTW6;D3DX18;F5H3A8;J3KNP9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0045202 synapse;GO:0043083 synaptic cleft",
        "go_biological_process": "GO:1900272 negative regulation of long-term synaptic potentiation;GO:0048167 regulation of synaptic plasticity",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q6P5X5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P68106-1",
        "uniprot_id": "FKB1B_HUMAN",
        "mass": 11783.0,
        "length": 108,
        "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP1B",
        "gene_name": "FKBP1B",
        "organism": "Human",
        "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP1B isoform a",
        "refseq_ac": "NP_004107",
        "gene_names_uniprotkb": "FKBP1B; FKBP12.6; FKBP1L; FKBP9; OTK4",
        "gene_names_refseq": "FKBP12.6; FKBP1B; FKBP1L; OTK4; PKBP1L; PPIase",
        "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP1B; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; 5.2.1.8; FK506-binding protein 1B; FKBP-12.6; FKBP-1B; Immunophilin FKBP12.6; PPIase FKBP1B; Rotamase; h-FKBP-12",
        "protein_names_refseq": "12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FK506 binding protein 1B, 12.6 kDa; FK506-binding protein 12.6; FK506-binding protein 1B; FKBP-12.6; FKBP-1B; PPIase FKBP1B; calstabin 2; h-FKBP-12; immunophilin FKBP12.6; peptidyl-prolyl cis-trans isomerase FKBP1B isoform a; peptidyl-prolyl cis-trans isomerase FKBP1B; rotamase",
        "tax_id": 9606,
        "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); short QT syndrome (Disease Ontology:DOID:0050793); catecholaminergic polymorphic ventricular tachycardia (Disease Ontology:DOID:0060674); Graves' disease (Disease Ontology:DOID:12361); anemia (Disease Ontology:DOID:2355); congestive heart failure (Disease Ontology:DOID:6000)",
        "pathway": " (hsa:2281);  (R-HSA-2672351);  (R-HSA-5578775)",
        "pathway_count": 3,
        "publication_count": 141,
        "publication_id_list": "10220561;10564087;10642508;10713512;10720933;10767424;10830164;10831588;10913253;11062458;11182090;11237011;11588175;11687798;11734858;11842292;11904445;11904675;11956057;12119109;12393854;12832055;12907679;12953268;1379744;14584882;14634667;15010458;15044642;15147738;15174025;15260953;15318163;15504734;15505377;15598648;15754088;15916532;15919655;16122887;16219661;16754674;16813530;16849430;16850186;1693919;17224452;17357072;17381423;17448995;17486119;17699613;17881003;18000046;18063579;18310267;18400985;18449189;18508966;18662336;18724360;18995841;19153159;19278978;19307298;19380724;19387438;19620632;19751721;19808995;19953639;20388639;20388710;20466723;20525693;20538786;21040849;21108950;21527911;21984732;22002868;22210847;2226863;22427649;22707725;22773952;22946059;22972900;2298749;23112050;2321095;23362265;23549614;23610579;23616951;2430951;2477373;2536303;2559024;25994790;26359375;26562072;27154203;27670942;27760856;28071645;28154142;2838329;28645727;28790369;2953725;29557506;31848261;32157095;32669538;35051231;6328127;7513996;7588753;7592869;7665160;7702581;7795595;7929371;8041726;8112288;8383669;8533761;8544406;8626462;8798450;8809036;8918259;9037075;9346285;9395096;9571199;9662395;9700209;9719863;9744806",
        "class_list": "",
        "function": "Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Our FRET-based HTS detects RyR binding of accessory proteins calmodulin (CaM) or FKBP12.6...One compound increased FRET and inhibited RyR1, which was only significant at nM [Ca(2+)], and accentuated without CaM present., [RefSeq, PubMed]; Results suggest that both FKBP12.6 and FKBP12 play critical roles in regulating RyR2 function by facilitating the termination of SOICR., [RefSeq, PubMed]; Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-kappaB/cyclin D1 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]; Total chemical synthesis, refolding, and crystallographic structure of fully active immunophilin calstabin 2, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "secondary_ac_list": "Q13664;Q16645;Q53TM2;Q9BQ40",
        "ec_number_list": "5.2.1.8;1.11.1.-;1.8.-.-;1.14.11.16",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005246 calcium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0019855 calcium channel inhibitor activity;GO:0005528 FK506 binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030018 Z disc;GO:0034704 calcium channel complex;GO:0033017 sarcoplasmic reticulum membrane",
        "go_biological_process": "GO:0050849 negative regulation of calcium-mediated signaling;GO:0051280 negative regulation of release of sequestered calcium ion into cytosol;GO:0019722 calcium-mediated signaling;GO:0051775 response to redox state;GO:0010459 negative regulation of heart rate",
        "synthesized_glycan_count": 0,
        "hit_score": 14.2,
        "record_id": "P68106-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13557-1",
        "uniprot_id": "KCC2D_HUMAN",
        "mass": 56369.0,
        "length": 499,
        "protein_name": "Calcium/calmodulin-dependent protein kinase type II subunit delta",
        "gene_name": "CAMK2D",
        "organism": "Human",
        "refseq_name": "calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3",
        "refseq_ac": "NP_001212",
        "gene_names_uniprotkb": "CAMK2D; CAMKD",
        "gene_names_refseq": "CAMK2D; CAMKD",
        "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type II subunit delta; 2.7.11.17; CaM kinase II subunit delta; CaMK-II subunit delta",
        "protein_names_refseq": "CaM kinase II delta subunit; CaM-kinase II delta chain; CaMK-II delta subunit; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase type II delta chain; calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3; calcium/calmodulin-dependent protein kinase type II subunit delta",
        "tax_id": 9606,
        "disease": "heart conduction disease (Disease Ontology:DOID:10273); renovascular hypertension (Disease Ontology:DOID:1591); epilepsy (Disease Ontology:DOID:1826); myocardial infarction (Disease Ontology:DOID:5844)",
        "pathway": " (hsa:817);  (R-HSA-111932);  (R-HSA-3371571);  (R-HSA-399719);  (R-HSA-438066);  (R-HSA-442982);  (R-HSA-5576892);  (R-HSA-5578775);  (R-HSA-5673000);  (R-HSA-5673001);  (R-HSA-6802946);  (R-HSA-6802952);  (R-HSA-6802955);  (R-HSA-877300);  (R-HSA-9022692);  (R-HSA-936837);  (R-HSA-9609736);  (R-HSA-9617324);  (R-HSA-9620244);  (R-HSA-9649948);  (R-HSA-9656223);  (R-HSA-9918481)",
        "pathway_count": 22,
        "publication_count": 383,
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        "class_list": "",
        "function": "CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma., [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Role of CAMK2D in neurodevelopment and associated conditions. Erratum:[Am J Hum Genet. 2025 Sep 4;112(9):2247. doi: 10.1016/j.ajhg.2025.08.001. PMID: 40795868], [RefSeq, PubMed]; The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]., [RefSeq]",
        "predicted_glycosites": 1,
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        "predicted_o_glycosites": 1,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
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        "biomarker_type": "",
        "glycan_count": 1,
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        "secondary_ac_list": "A8MVS8;Q52PK4;Q59G21;Q8N553;Q9UGH6;Q9UQE9",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;7.2.2.10;2.3.2.27;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.10.1;2.7.2.3;3.6.5.2;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;3.1.3.48;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;3.1.3.16;2.7.11.31;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;2.7.1.107;2.7.1.94;2.7.1.138;3.6.5.-;2.7.7.-;2.7.7.19;1.14.11.65;3.1.31.1;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0019871 sodium channel inhibitor activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density",
        "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0086003 cardiac muscle cell contraction;GO:1901897 regulation of relaxation of cardiac muscle;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 38.9,
        "record_id": "Q13557-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A1A580-1",
        "uniprot_id": "KR231_HUMAN",
        "mass": 6892.0,
        "length": 65,
        "protein_name": "Keratin-associated protein 23-1",
        "gene_name": "KRTAP23-1",
        "organism": "Human",
        "refseq_name": "keratin-associated protein 23-1",
        "refseq_ac": "NP_853655",
        "gene_names_uniprotkb": "KRTAP23-1; KAP23.1",
        "gene_names_refseq": "KAP23.1; KRTAP23-1",
        "protein_names_uniprotkb": "Keratin-associated protein 23-1",
        "protein_names_refseq": "keratin-associated protein 23-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:337963);  (R-HSA-6805567)",
        "pathway_count": 2,
        "publication_count": 10,
        "publication_id_list": "15373777;16382671;1691188;1694855;1714783;17521629;23481192;2414304;25208914;9468612",
        "class_list": "",
        "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005882 intermediate filament",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "A1A580-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N6N6-1",
        "uniprot_id": "NATD1_HUMAN",
        "mass": 13032.0,
        "length": 113,
        "protein_name": "Protein NATD1",
        "gene_name": "NATD1",
        "organism": "Human",
        "refseq_name": "protein NATD1",
        "refseq_ac": "NP_690878",
        "gene_names_uniprotkb": "NATD1; C17orf103; GTLF3B",
        "gene_names_refseq": "C17orf103; Gtlf3b; NATD1",
        "protein_names_uniprotkb": "Protein NATD1; N-acetyltransferase domain-containing protein 1",
        "protein_names_refseq": "N-acetyltransferase domain-containing protein 1; gene trap locus F3b; protein GTLF3B; protein NATD1; transcript expressed during hematopoiesis 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:256302)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "29557506;29789417;30429286;32488085;33435607;35580925;36284347",
        "class_list": "",
        "function": "Development of A Continuous Fluorescence-Based Assay for N-Terminal Acetyltransferase D. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MWQ7;B3KX70",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8N6N6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95453-1",
        "uniprot_id": "PARN_HUMAN",
        "mass": 73451.0,
        "length": 639,
        "protein_name": "Poly(A)-specific ribonuclease PARN",
        "gene_name": "PARN",
        "organism": "Human",
        "refseq_name": "poly(A)-specific ribonuclease PARN isoform 2",
        "refseq_ac": "NP_001127949",
        "gene_names_uniprotkb": "PARN; DAN",
        "gene_names_refseq": "DAN; DKCB6; PARN; PFBMFT4",
        "protein_names_uniprotkb": "Poly(A)-specific ribonuclease PARN; 3.1.13.4; Deadenylating nuclease; Deadenylation nuclease; Polyadenylate-specific ribonuclease",
        "protein_names_refseq": "deadenylating nuclease; deadenylation nuclease; poly(A)-specific ribonuclease PARN isoform 2; polyadenylate-specific ribonuclease",
        "tax_id": 9606,
        "disease": "autosomal recessive dyskeratosis congenita 6 (Disease Ontology:DOID:0070024); pulmonary fibrosis and/or bone marrow failure, Telomere-related, 4 (MONDO:MONDO:0014612)",
        "pathway": " (hsa:5073);  (R-HSA-380994);  (R-HSA-429947);  (R-HSA-450604)",
        "pathway_count": 4,
        "publication_count": 160,
        "publication_id_list": "10.1101/2023.09.13.557529;10637334;10640832;10698948;10801819;10882133;10958673;11237011;11283721;11359775;11719186;11742007;11889047;12429849;12748283;1355481;14527413;14583602;14731398;14742429;14749774;15175153;15358788;15385533;15475613;15514971;16141059;16281054;16284618;16364914;16601207;16648466;16687408;16912112;16931790;16964243;16989641;17052452;17081983;17245413;17322306;17595167;18212344;18285520;18625844;18669648;18684992;18767875;18840095;19141871;19198587;19239894;19413330;19558367;19608861;19651622;19664995;19690332;19854161;20022965;20058876;20068231;20361218;20932473;21406692;21876179;22442037;22802018;22819556;22978410;23186163;23269699;23301498;23481700;24275569;24366607;24714562;24715725;25049417;25418920;25480299;25576301;25645385;25802875;25848748;25892735;25893599;26154972;26375851;2663993;2664463;26728094;26992070;27600516;27846572;27862975;27920218;28063628;28228285;28832583;28834231;28904123;29242379;29393594;29413899;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30429286;31154438;31217245;31387300;31448843;31844290;31848261;31936572;32157095;32357974;32387766;32457045;32502341;3260265;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;34087483;34171305;34185709;34211107;34405274;34509645;34561969;34932366;35051231;35251023;35318648;35580925;36010968;36241641;36284347;36581221;40914422;9099687;9736620",
        "class_list": "",
        "function": "3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Deadenylation by the mammalian and amphibian poly(A)-specific exoribonuclease, PARN, is stimulated by the presence of an m(7)-guanosine cap on substrate RNAs. PARN exhibits intrinsic cap-binding activity., [RefSeq, PubMed]; Intrinsically disordered PARN C-terminal domain is required for PARN nuclear localization in response to DNA damage. Publication Status: Online-Only, [RefSeq, PubMed]; PARN is a poly(A)-specific member of the RNase D family of 3' exoribonucleases. It is distributed between the nucleus and the cytoplasm and is not stably associated with ribosomes. Xenopus PARN catalyzes deadenylation during oocyte maturation., [RefSeq, PubMed]; Regulation of poly(a)-specific ribonuclease activity by reversible lysine acetylation., [RefSeq, PubMed]; Study reports a family with idiopathic pulmonary fibrosis with a rare missense mutation, p.Y91C, and a novel insertion, p.(I274*) in PARN gene.  PARN p.Y91C had reduced deadenylase activity and the p.(I274*) transcript was depleted., [RefSeq, PubMed]; The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]., [RefSeq]; Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN). Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 17,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCB3;B4DDG8;B4DSB0;B4DWR4;B4E1H6",
        "ec_number_list": "3.1.13.4;3.6.4.13;3.6.1.62;3.1.13.-;3.1.26.-",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0003730 mRNA 3'-UTR binding;GO:0004518 nuclease activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0009451 RNA modification;GO:0007292 female gamete generation;GO:0000495 box H/ACA sno(s)RNA 3'-end processing",
        "synthesized_glycan_count": 0,
        "hit_score": 16.8,
        "record_id": "O95453-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14432-1",
        "uniprot_id": "PDE3A_HUMAN",
        "mass": 124979.0,
        "length": 1141,
        "protein_name": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A",
        "gene_name": "PDE3A",
        "organism": "Human",
        "refseq_name": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1",
        "refseq_ac": "NP_000912",
        "gene_names_uniprotkb": "PDE3A",
        "gene_names_refseq": "CGI-PDE A; CGI-PDE-A; CGI-PDE; HTNB; PDE3A",
        "protein_names_uniprotkb": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A; 3.1.4.17; CGI-PDE A; Cyclic GMP-inhibited phosphodiesterase A; cGI-PDE; cGMP-inhibited cAMP phosphodiesterase",
        "protein_names_refseq": "cAMP phosphodiesterase, myocardial cGMP-inhibited; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cGMP-inhibited cAMP phosphodiesterase; cyclic GMP-inhibited phosphodiesterase A; phosphodiesterase 3A, cGMP-inhibited",
        "tax_id": 9606,
        "disease": "hypertension and brachydactyly syndrome (Disease Ontology:DOID:0111247); pulmonary hypertension (Disease Ontology:DOID:6432); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:5139);  (R-HSA-418555)",
        "pathway_count": 2,
        "publication_count": 104,
        "publication_id_list": "10421499;11007482;12036966;12058044;12106601;12180353;12860470;1315035;13549488;14671004;1517224;15765929;15769620;15951850;16153182;16313925;16687412;16923326;16964243;17081983;17168849;17322306;18044684;18088087;18212344;18577758;18669648;18767875;19105585;19261611;19876791;19929708;20068231;20112406;20166139;20381629;21036126;2163110;23186163;2417744;24687066;2491850;2553411;2553705;25961942;26154972;26417854;27975297;28510447;2871555;28832583;29393594;29443750;29557506;29602314;29632711;29789417;30429286;30484775;30833945;30833991;3127824;31279028;31289200;31373491;31399091;31420216;31844290;31983287;32157095;32161166;32226383;32265295;32387766;32488085;32497535;32540603;32618402;32715661;33049737;33912179;34171305;34252457;34272366;34707099;35051231;35580925;36241641;36259389;36284347;36876489;37035914;37244472;37938771;38244313;6085243;8155697;8340388;8514797;8672451;8695850;9263355;9417641;9651336",
        "class_list": "",
        "function": "ALDOA coordinates PDE3A through the beta-catenin/ID3 axis to stimulate cancer metastasis and M2 polarization in lung cancer with EGFR mutations., [RefSeq, PubMed]; Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure., [RefSeq, PubMed]; Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage., [RefSeq, PubMed]; Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage., [RefSeq, PubMed]; Mutations in Phosphodiesterase 3A (PDE3A) Cause Hypertension Without Cardiac Damage. Review article, [RefSeq, PubMed]; This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 49,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60865;Q13348;Q17RD1",
        "ec_number_list": "3.1.4.-;3.1.4.17;3.1.4.53;3.1.4.35;3.1.4.1;3.6.1.9;3.6.1.25;3.6.1.14",
        "go_molecular_function": "GO:0004119 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity;GO:0046872 metal ion binding;GO:0030284 nuclear estrogen receptor activity;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0043116 negative regulation of vascular permeability;GO:0097190 apoptotic signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "Q14432-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96CS7-1",
        "uniprot_id": "PKHB2_HUMAN",
        "mass": 24736.0,
        "length": 222,
        "protein_name": "Pleckstrin homology domain-containing family B member 2",
        "gene_name": "PLEKHB2",
        "organism": "Human",
        "refseq_name": "pleckstrin homology domain-containing family B member 2 isoform 3",
        "refseq_ac": "NP_001094093",
        "gene_names_uniprotkb": "PLEKHB2; EVT2",
        "gene_names_refseq": "EVT2; PLEKHB2",
        "protein_names_uniprotkb": "Pleckstrin homology domain-containing family B member 2; Evectin-2; PH domain-containing family B member 2",
        "protein_names_refseq": "PH domain-containing family B member 2; evectin-2; pleckstrin homology domain containing, family B (evectins) member 2; pleckstrin homology domain-containing family B member 2 isoform 3; pleckstrin homology domain-containing family B member 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55041)",
        "pathway_count": 1,
        "publication_count": 67,
        "publication_id_list": "11237011;17697703;21911378;22281740;22645359;24715725;25418920;25502872;25576301;25645385;25892735;26024233;26154972;26375851;26992070;27600516;28218747;28228285;28446606;28832583;28834231;29093443;29242379;29437277;29493099;29508533;29557506;29769354;29786170;29789417;30315122;30410026;30429286;30626607;30779550;31092671;31154438;31217245;31844290;32157095;32161166;32350084;32357974;32387766;32488085;32897882;32938616;32983136;33537174;33592498;33633747;33691108;33912179;33968037;33981976;34171305;34185709;34357683;34509645;35051231;35154160;35561310;35580925;36010968;36241641;36284347;37938771",
        "class_list": "",
        "function": "Data show that depletion of evt-2 or masking of intracellular PS suppressed membrane traffic from REs to the Golgi., [RefSeq, PubMed]; Involved in retrograde transport of recycling endosomes., [UniProtKB, PubMed, PubMed]; Knockdown of evectin-2 (a recycling endosome-resident protein) suppresses nuclear localization of YAP and YAP-dependent transcription. Evectin-2 knockdown reduces the ubiquitination and increased the level of Lats1. Publication Status: Online-Only, [RefSeq, PubMed]; The crystal structure at 1.75 A resolution of an apo form of human evectin-2 pleckstrin homology domain, in which the ligand-binding site is free from crystal packing and is thus appropriate for comparison with the structure of the complex, is reported., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "B4DF08;B4DZ66;B8ZZN1;Q53FF1;Q53TH7;Q86W37;Q9BV75;Q9NWK1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding",
        "go_cellular_component": "GO:0016020 membrane;GO:0055038 recycling endosome membrane",
        "go_biological_process": "GO:0045595 regulation of cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
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        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BRQ0-1",
        "uniprot_id": "PYGO2_HUMAN",
        "mass": 41244.0,
        "length": 406,
        "protein_name": "Pygopus homolog 2",
        "gene_name": "PYGO2",
        "organism": "Human",
        "refseq_name": "pygopus homolog 2",
        "refseq_ac": "NP_612157",
        "gene_names_uniprotkb": "PYGO2; PP7910",
        "gene_names_refseq": "1190004M21Rik; PYGO2",
        "protein_names_uniprotkb": "Pygopus homolog 2",
        "protein_names_refseq": "pygopus 2; pygopus homolog 2",
        "tax_id": 9606,
        "disease": "heart conduction disease (Disease Ontology:DOID:10273)",
        "pathway": " (hsa:90780);  (R-HSA-201722);  (R-HSA-3769402)",
        "pathway_count": 3,
        "publication_count": 124,
        "publication_id_list": "10080941;10485845;10549281;10769018;10775268;10831834;10898789;10921920;10944533;11050151;11080158;11136974;11237011;11532957;11691915;11713476;11934263;11955446;11973335;11988739;12163411;12408824;12408825;12712206;14600025;14685266;14695187;15060161;15121853;15132997;15294866;15327769;15498874;15525529;15768032;15829968;16005293;16169192;16510874;16609037;16630820;16756492;16964243;17052462;17218525;17322306;17412698;17425782;17428831;17458864;17698607;17875931;17924679;18160704;18212344;18347063;18378692;18404694;18456656;18498752;18573912;18598779;18669648;18767875;18819930;19047045;19148484;19364920;19413330;19415658;19460168;19487454;19493659;19571879;19590513;19651622;19664994;19664995;19928349;19940019;20068231;21406692;21654818;21726809;22186018;22190459;22304967;22617422;22982193;23186163;24275569;24291232;26992070;28832583;29242379;30315122;30379171;30779550;31092671;31217245;31844290;32161166;32387766;32938616;33633747;33981976;34019948;35051231;36010968;36241641;36404439;36688188;37233752;37423512;38229324;8756721;8757136;8955148;9118222;9488439;9490669;9751710;9819412;9843967",
        "class_list": "",
        "function": "Association of Single Nucleotide Polymorphisms in the PYGO2 and PRDM9 Genes with Idiopathic Azoospermia in Iranian Infertile Male Patients., [RefSeq, PubMed]; Interference of EFNA4 suppresses cell proliferation, invasion and angiogenesis in hepatocellular carcinoma by downregulating PYGO2., [RefSeq, PubMed]; Involved in signal transduction through the Wnt pathway., [UniProtKB, UniProtKB, UniProtKB]; Novel biphasic mechanism of the canonical Wnt signalling component PYGO2 promotes cardiomyocyte differentiation from hUC-MSCs., [RefSeq, PubMed]; PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma., [RefSeq, PubMed]; Pygo2 activates BRPF1 via Pygo2-H3K4me2/3 interaction to maintain malignant progression in colon cancer., [RefSeq, PubMed]; The Expression of pygopus 2 protein mRNA levels were significantly higher in the epithelial ovarian cancer cell lines., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
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        "reported_mutagensis": 0,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WYZ4;Q96CY2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:1990907 beta-catenin-TCF complex",
        "go_biological_process": "GO:0016055 Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 12.7,
        "record_id": "Q9BRQ0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6RVD6-1",
        "uniprot_id": "SPAT8_HUMAN",
        "mass": 11727.0,
        "length": 105,
        "protein_name": "Spermatogenesis-associated protein 8",
        "gene_name": "SPATA8",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "SPATA8",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Spermatogenesis-associated protein 8; Spermatogenesis-related protein 8",
        "protein_names_refseq": "",
        "tax_id": 9606,
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        "publication_id_list": "16809841;29557506",
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    {
        "uniprot_canonical_ac": "P40763-1",
        "uniprot_id": "STAT3_HUMAN",
        "mass": 88068.0,
        "length": 770,
        "protein_name": "Signal transducer and activator of transcription 3",
        "gene_name": "STAT3",
        "organism": "Human",
        "refseq_name": "signal transducer and activator of transcription 3 isoform 2",
        "refseq_ac": "NP_003141",
        "gene_names_uniprotkb": "STAT3; APRF",
        "gene_names_refseq": "ADMIO1; ADMIO; APRF; HIES; STAT3",
        "protein_names_uniprotkb": "Signal transducer and activator of transcription 3; Acute-phase response factor",
        "protein_names_refseq": "DNA-binding protein APRF; acute-phase response factor; signal transducer and activator of transcription 3 isoform 2",
        "tax_id": 9606,
        "disease": "angiosarcoma (Disease Ontology:DOID:0001816); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); inflammatory bowel disease (Disease Ontology:DOID:0050589); pre-malignant neoplasm (Disease Ontology:DOID:0060071); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); infantile onset multisystem autoimmune disease (Disease Ontology:DOID:0061159); infantile onset multisystem autoimmune disease 1 (Disease Ontology:DOID:0061160); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hyper IgE syndrome (Disease Ontology:DOID:0080545); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); esophageal carcinoma (Disease Ontology:DOID:1107); heart disease (Disease Ontology:DOID:114); neutropenia (Disease Ontology:DOID:1227); Behcet's disease (Disease Ontology:DOID:13241); breast cancer (Disease Ontology:DOID:1612); duodenal ulcer (Disease Ontology:DOID:1724); squamous cell carcinoma (Disease Ontology:DOID:1749); hyperuricemia (Disease Ontology:DOID:1920); atherosclerosis (Disease Ontology:DOID:1936); rectum adenocarcinoma (Disease Ontology:DOID:1996); nephroblastoma (Disease Ontology:DOID:2154); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); Churg-Strauss syndrome (Disease Ontology:DOID:3049); glioblastoma (Disease Ontology:DOID:3068); autosomal dominant hyper-IgE syndrome 1 with recurrent infections (Disease Ontology:DOID:3261); angiomyolipoma (Disease Ontology:DOID:3314); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); psoriatic arthritis (Disease Ontology:DOID:9008); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); peripartum cardiomyopathy (Disease Ontology:DOID:9997)",
        "pathway": " (hsa:6774);  (R-HSA-1059683);  (R-HSA-111453);  (R-HSA-1266695);  (R-HSA-1433557);  (R-HSA-1839117);  (R-HSA-186763);  (R-HSA-198745);  (R-HSA-201556);  (R-HSA-2559582);  (R-HSA-2586552);  (R-HSA-2892247);  (R-HSA-390471);  (R-HSA-452723);  (R-HSA-6783783);  (R-HSA-6785807);  (R-HSA-8849474);  (R-HSA-8854691);  (R-HSA-8875791);  (R-HSA-8983432);  (R-HSA-8984722);  (R-HSA-8985947);  (R-HSA-9008059);  (R-HSA-9020933);  (R-HSA-9020956);  (R-HSA-9020958);  (R-HSA-9616222);  (R-HSA-9670439);  (R-HSA-9673767);  (R-HSA-9673770);  (R-HSA-9674555);  (R-HSA-9680350);  (R-HSA-9701898);  (R-HSA-9705462);  (R-HSA-9707564);  (R-HSA-9725370);  (R-HSA-9725371);  (R-HSA-982772);  (R-HSA-9833482);  (R-HSA-9909649);  (R-HSA-9958825)",
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        "function": "GdX inhibits the occurrence and progression of breast cancer by negatively modulating the activity of STAT3., [RefSeq, PubMed]; LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated inflammatory activation via the miR-30b-5p/SOC3 axis in THP-1 cells. Publication Status: Online-Only, [RefSeq, PubMed]; STAT1 and STAT3 gain of function: clinically heterogenous immune regulatory disorders. Review article, [RefSeq, PubMed]; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:11294841, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18242580, PubMed:18782771, PubMed:22306293, PubMed:23084476, PubMed:28262505, PubMed:32929201, PubMed:38404237). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18782771, PubMed:28262505, PubMed:32929201). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (PubMed:28065600, PubMed:28262505). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (PubMed:9188471)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The STAT3/SETDB2 axis dictates NF-kappaB-mediated inflammation in macrophages during wound repair. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 45,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 56,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "diagnostic; prognostic",
        "glycan_count": 2,
        "disease_count": 52,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7B8;K7ENL3;O14916;Q9BW54",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0038110 interleukin-2-mediated signaling pathway;GO:0048708 astrocyte differentiation;GO:2001171 positive regulation of ATP biosynthetic process;GO:1905564 positive regulation of vascular endothelial cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 228.1,
        "record_id": "P40763-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92537-1",
        "uniprot_id": "SUSD6_HUMAN",
        "mass": 32090.0,
        "length": 303,
        "protein_name": "Sushi domain-containing protein 6",
        "gene_name": "SUSD6",
        "organism": "Human",
        "refseq_name": "sushi domain-containing protein 6 precursor",
        "refseq_ac": "NP_055549",
        "gene_names_uniprotkb": "SUSD6; DRAGO; KIAA0247",
        "gene_names_refseq": "DRAGO; KIAA0247; SUSD6",
        "protein_names_uniprotkb": "Sushi domain-containing protein 6; Drug-activated gene overexpressed protein",
        "protein_names_refseq": "drug-activated gene overexpressed protein; sushi domain-containing protein 6 precursor; sushi domain-containing protein 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9766)",
        "pathway_count": 1,
        "publication_count": 42,
        "publication_id_list": "18446792;20236627;21619678;24652652;25502872;25892735;26992070;27862975;27893430;28467828;28832583;28904123;29242379;29314611;29393594;29451718;29557506;29632046;29769354;30315122;30833945;31154438;31530632;31844290;31848261;32161166;32350084;32387766;32983136;33912179;33968037;33981976;34078123;34171305;34357683;34932366;35051231;35154160;35318648;35580925;36284347;37938771",
        "class_list": "",
        "function": "DRAGO (drug-activated gene overexpressed) KIAA0247 represents a new p53-dependent gene highly regulated in human cells and whose expression cooperates with p53 in tumor suppressor functions. Erratum:[J Natl Cancer Inst. 2014 Aug;106(8):dju199 doi:10.1093/jnci/dju199], [RefSeq, PubMed]; Gene silencing in umbilical vein endothelial cells causes decrease in monocyte chemoattractant protein-1 production during endotoxemia, [RefSeq, PubMed]; KIAA0247 is a candidate prognostic biomarker and potential therapeutic target in NSCLC., [RefSeq, PubMed]; May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Overexpression of KIAA0247 is able to inhibit phosphorylation of AKT and Stat3 in glioma cells, resulting in inactivation of the AKT and Stat3 signaling pathways, this ultimately decreases the expression of PCNA, CyclinD1, Bcl2 and VEGF., [RefSeq, PubMed]; This is the first description of a linkage between KIAA0247 and colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "GO:0006974 DNA damage response",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q92537-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8K0Z3-1",
        "uniprot_id": "WASH1_HUMAN",
        "mass": 50328.0,
        "length": 465,
        "protein_name": "WASH complex subunit 1",
        "gene_name": "WASHC1",
        "organism": "Human",
        "refseq_name": "WASH complex subunit 1",
        "refseq_ac": "NP_878908",
        "gene_names_uniprotkb": "WASHC1; FAM39E; WASH1",
        "gene_names_refseq": "FAM39E; WASH1; WASHC1; WASH",
        "protein_names_uniprotkb": "WASH complex subunit 1; CXYorf1-like protein on chromosome 9; Protein FAM39E; WAS protein family homolog 1",
        "protein_names_refseq": "CXYorf1-like protein on chromosome 9; FLJ00075 protein; WAS protein family homolog 1; WASH complex subunit 1; actin nucleation promoting factor; family with sequence similarity 39, member E",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100287171)",
        "pathway_count": 1,
        "publication_count": 59,
        "publication_id_list": "10655549;11237011;18159949;19922874;19922875;20498093;20707881;22114305;23452853;23783831;24344185;24715725;26154972;27600516;27846572;27862975;28228285;28514659;28551275;28589939;28832583;28834231;28904123;29084197;29242379;29393594;29493099;29508533;29786170;29789417;29891722;30315122;30429286;30524438;31092671;31844290;32157095;32350084;32357974;32387766;32488085;32897882;32938616;32983136;33392160;33691108;33968037;34211107;34509645;35051231;35318648;35561310;35580925;35733063;36010968;36241641;36284347;37938771;41073792",
        "class_list": "",
        "function": "(Microbial infection) Nucleation-promoting factor that plays a major role in human papillomavirus infection by facilitating branched actin-driven scission in endocytosis., [UniProtKB, PubMed]; Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; In this study, we uncover an alternative role for the ESCRT-0 component hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) in promoting the constitutive recycling of transmembrane proteins. We find that endosomal localization of the actin nucleating factor Wiscott-Aldrich syndrome protein and SCAR homologue (WASH) requires HRS, which occupies adjacent endosomal subdomains, [RefSeq, PubMed]; Its mutation is not found in a cohort of German patients with sporadic amyotrophic lateral sclerosis and frontotemporal lobar degeneration comorbidity., [RefSeq, PubMed]; WASH exists in a multiprotein complex containing FAM21, which links WASH to endosomes and is required for WASH-dependent retromer-mediated sorting., [RefSeq, PubMed]; WASH-mediated AHR expression has a critical function in the maintenance of NKp46+ innate lymphoid cells Publication Status: Online-Only, [RefSeq, PubMed]; WASHC1 interacts with MCM2-7 complex to promote cell survival under replication stress., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0031625 ubiquitin protein ligase binding;GO:0043014 alpha-tubulin binding;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity",
        "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane",
        "go_biological_process": "GO:0015031 protein transport;GO:0022617 extracellular matrix disassembly;GO:0030335 positive regulation of cell migration;GO:0010507 negative regulation of autophagy;GO:0016197 endosomal transport",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "A8K0Z3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H3F6-1",
        "uniprot_id": "BACD3_HUMAN",
        "mass": 35432.0,
        "length": 313,
        "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3",
        "gene_name": "KCTD10",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 1",
        "refseq_ac": "NP_001304324",
        "gene_names_uniprotkb": "KCTD10; MSTP028; ULR061",
        "gene_names_refseq": "BTBD28; KCTD10; MSTP028; ULRO61; hBACURD3",
        "protein_names_uniprotkb": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; BTB/POZ domain-containing protein KCTD10; Potassium channel tetramerization domain-containing protein 10; hBACURD3",
        "protein_names_refseq": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 1; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; BTB/POZ domain-containing protein KCTD10; potassium channel tetramerisation domain containing 10; potassium channel tetramerization domain-containing protein 10",
        "tax_id": 9606,
        "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)",
        "pathway": " (hsa:83892)",
        "pathway_count": 1,
        "publication_count": 79,
        "publication_id_list": "11237011;18669648;18991276;19125419;19154347;19691289;19782033;22544926;23186163;23481700;24714562;24715725;25418920;25505266;25576301;25645385;26154972;26375851;26929215;26992070;27600516;27846572;27862975;27920218;28063628;28228285;28832583;28834231;28904123;28963344;29242379;29358211;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30404837;30429286;30484775;30779550;30833945;31154438;31217245;31222486;31511519;31844290;31848261;31937595;32157095;32265295;32350084;32357974;32387766;32502341;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33936100;33968037;34171305;34211107;34509645;34561969;35051231;35580925;36010968;36284347;36581221;37938771;38959043;41062692",
        "class_list": "",
        "function": "Binding of SP1 to the proximal promoter region stimulated the promoter activity and endogenous KCTD10 expression, whereas binding of AP-2alpha to this region showed opposite effects., [RefSeq, PubMed]; KCTD10 may be associated with DNA synthesis and cell proliferation, [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of multiple substrates, leading to either their proteasomal or lysosomal degradation, or modulating their activity through non-degradative ubiquitination. Controls endothelial barrier function by mediating 'Lys-63'-linked polyubiquitination of RHOB, promoting its lysosomal degradation (PubMed:29358211). Mediates polyubiquitination of CEP97, targeting it for proteasomal degradation. CEP97 degradation upon serum starvation is essential for primary cilium formation by enabling removal of the CEP97-CP110 complex from mother centrioles (PubMed:30404837). Acts as a positive regulator of ferroptosis by destabilizing SLC7A11. Decreased SLC7A11 levels reduce cystine uptake and glutathione (GSH) biosynthesis, thereby promoting iron-dependent lipid peroxidation and ferroptotic cell death (PubMed:38959043). In the innate immune response, mediates 'Lys-27'-linked polyubiquitination of TICAM1/TRIF at Lys-523 upon stimulation with LPS. This ubiquitination is essential for recruitment of TICAM1 to TLR3/4, thereby promoting TLR3/4-mediated immune signaling (PubMed:31511519). Negatively regulates KCTD13 stability through the ubiquitin/proteasome degradation pathway within the developing brain to control neuronal progenitor cell proliferation and differentiation (By similarity). Acts as a sensor for co-directional transcription-replication conflicts, where it helps coordinate the interaction between the replication machinery and RNA polymerase to allow DNA replication to continue through actively transcribed regions. Promotes recruitment of ubiquitin ligase complexes that remove stalled transcription factors, thereby maintaining genome stability by resolving these conflicts. Ubiquitinates TCEA2 to remodel the RNAP complex (PubMed:41062692)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; The CRL3[KCTD10] ubiquitin ligase-USP18 axis coordinately regulates cystine uptake and ferroptosis by modulating SLC7A11., [RefSeq, PubMed]; The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53HN2;Q59FV1;Q6PL47;Q96SU0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005112 Notch binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0035024 negative regulation of Rho protein signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "Q9H3F6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75553-1",
        "uniprot_id": "DAB1_HUMAN",
        "mass": 63775.0,
        "length": 588,
        "protein_name": "Disabled homolog 1",
        "gene_name": "DAB1",
        "organism": "Human",
        "refseq_name": "disabled homolog 1 isoform 1",
        "refseq_ac": "NP_066566",
        "gene_names_uniprotkb": "DAB1",
        "gene_names_refseq": "DAB1; SCA37",
        "protein_names_uniprotkb": "Disabled homolog 1",
        "protein_names_refseq": "DAB1, reelin adaptor protein; Dab reelin signal transducer 1; Dab, reelin signal transducer, homolog 1; disabled homolog 1 isoform 1; disabled homolog 1; spinocerebellar ataxia 37; yotari",
        "tax_id": 9606,
        "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); spinocerebellar ataxia 37 (Disease Ontology:DOID:0050984); brain glioma (Disease Ontology:DOID:0060108); Alzheimer's disease (Disease Ontology:DOID:10652); autistic disorder (Disease Ontology:DOID:12849); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); middle cerebral artery infarction (Disease Ontology:DOID:3525); diabetic retinopathy (Disease Ontology:DOID:8947); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:1600);  (R-HSA-8866376)",
        "pathway_count": 2,
        "publication_count": 29,
        "publication_id_list": "10571241;11237011;12077184;12446734;15272003;16529723;17350651;18076569;18593473;19116273;21111810;23052211;23506116;27602387;28228285;28686858;29557506;29590626;30379171;33064976;33572344;35580925;35977442;35989311;38093390;38919020;9049633;9790777;9861036",
        "class_list": "",
        "function": "ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of microRNA-300 inhibits cell adhesion, migration, and invasion of prostate cancer cells by promoting the expression of DAB1., [RefSeq, PubMed]; Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development. Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain., [UniProtKB, UniProtKB]; The heterotrimeric kinesin-2 family member KIF3A directly binds to disabled-1 (Dab1)., [RefSeq, PubMed]; The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]., [RefSeq]; Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 12,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4FU90;B3KTG3;Q4LE59;Q5T6M6;Q5T6M9;Q5T835;Q5T836;Q5T837;Q6NWS9;Q6NWT0;Q6NWT1;Q9NYA8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0035591 signaling adaptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0001764 neuron migration;GO:0021819 layer formation in cerebral cortex;GO:0038026 reelin-mediated signaling pathway;GO:0090128 regulation of synapse maturation;GO:0097477 lateral motor column neuron migration",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "O75553-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q12873-1",
        "uniprot_id": "CHD3_HUMAN",
        "mass": 226592.0,
        "length": 2000,
        "protein_name": "ATP-dependent chromatin remodeler CHD3",
        "gene_name": "CHD3",
        "organism": "Human",
        "refseq_name": "ATP-dependent chromatin remodeler CHD3 isoform 3",
        "refseq_ac": "NP_001005271",
        "gene_names_uniprotkb": "CHD3",
        "gene_names_refseq": "CHD3; Mi-2a; Mi2-ALPHA; SNIBCPS; ZFH",
        "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD3; 3.6.4.-; CHD-3; Chromo domain-containing protein 3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase-like; hZFH",
        "protein_names_refseq": "ATP-dependent chromatin remodeler CHD3 isoform 3; ATP-dependent chromatin remodeler CHD3; ATP-dependent helicase CHD3; CHD-3; chromo domain-containing protein 3; hZFH; mi-2 autoantigen 240 kDa protein; zinc finger helicase-like; zinc finger helicase; zinc-finger helicase (Snf2-like)",
        "tax_id": 9606,
        "disease": "Snijders Blok-Campeau syndrome (Disease Ontology:DOID:0070668); pancreatic carcinoma (Disease Ontology:DOID:4905)",
        "pathway": " (hsa:1107);  (R-HSA-3214815);  (R-HSA-427389);  (R-HSA-4551638);  (R-HSA-6804758);  (R-HSA-73762);  (R-HSA-8943724);  (R-HSA-9679191);  (R-HSA-9843940);  (R-HSA-9844594);  (R-HSA-9845323);  (R-HSA-9937850);  (R-HSA-9940951);  (R-HSA-9976102)",
        "pathway_count": 14,
        "publication_count": 268,
        "publication_id_list": "10082553;10087012;10204490;10330177;10444591;10449787;10748112;10904264;10913176;10922406;10926844;10970879;10978333;11099047;11230151;11237011;11250901;11378386;11509652;11545734;11739383;11742974;11781575;11909966;11959841;11959846;11960997;12032081;12032298;12183469;12393749;12419226;12504854;12505151;12724404;12869583;14536086;14578449;14609633;14701874;15199155;15302935;15456747;1547496;15516265;15592428;15643425;15701600;15882967;16115318;16186106;16415179;16418168;16428440;16522641;16567619;16676006;16702404;16707490;16839880;16954381;17018294;17081983;17211407;17318177;17322306;17626165;17646674;17662961;17873065;17974977;18082607;18172008;18391013;18408014;18452278;18487508;18571423;18628979;18656484;18669648;18691969;18691976;18767875;18794358;19413330;19440552;19651622;19690332;19884659;20058876;20068231;20098713;20112406;20223979;20228809;20233713;2028256;20351170;20417598;20516213;20523938;20660729;21289308;21490301;21587264;22128185;22398447;22401777;22402492;22493095;22552008;22684280;22814904;23186163;23239876;23287862;23361464;23431171;23481700;23641311;23750026;24029068;24068740;24252660;24272870;24275569;24307175;24369422;24385926;24554700;24584101;24715725;24718924;24782567;24920672;25114211;25150861;25218447;25274305;25391492;25418920;25576301;25593309;25645385;25704882;25728608;25753662;25801024;25880248;26002965;26101246;26154972;26375851;26768311;26811146;26813693;26910647;26929215;26992070;27068747;27418187;27418309;27600516;27633282;27732854;27806305;27846572;27920218;2805069;28063628;28218747;28228285;28273063;28425720;28514659;28533432;28832583;28834231;28904123;28977666;29042441;29242379;29351928;29393594;29437277;29463886;29508533;29557506;29632046;29632711;29786170;29945920;30045876;30122475;30134174;30201761;30228260;30315122;30327463;30340600;30397230;30429286;30779550;30833945;30980593;31048504;31154438;31217245;31289231;31427381;31746185;31844290;31848261;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32522876;32897882;32938616;32983136;33264408;33283408;33298915;33392160;33537174;33592498;33717175;33912179;33968037;34019948;34087483;34171305;34185709;35051231;35346573;35561310;35580925;36008597;36010968;36284347;37217939;37761804;37938771;38116750;38359823;40596516;7491500;7513682;7560064;7801123;7969165;8769649;9016654;9150135;9326634;9427644;9512513;9651585;9688266;9790534;9804427;9885572",
        "class_list": "",
        "function": "A severe neurocognitive phenotype caused by biallelic CHD3 variants in two siblings., [RefSeq, PubMed]; ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Inherited variants in CHD3 show variable expressivity in Snijders Blok-Campeau syndrome., [RefSeq, PubMed]; Snijders Blok-Campeau Syndrome: Description of 20 Additional Individuals with Variants in CHD3 and Literature Review. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 5,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 26,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DTQ9;E9PG89;Q9Y4I0",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;2.3.2.-;3.5.1.-;3.5.1.98;1.14.11.-;1.14.11.65;1.14.99.66;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;3.1.3.11;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;4.1.1.32;2.7.11.-;3.1.3.9;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.1.1.367;2.3.2.27;2.3.1.48;2.3.1.-;2.1.1.356;7.2.2.-;5.6.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;2.1.1.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3;2.1.1.37",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 27.1,
        "record_id": "Q12873-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q969U6-1",
        "uniprot_id": "FBXW5_HUMAN",
        "mass": 63922.0,
        "length": 566,
        "protein_name": "F-box/WD repeat-containing protein 5",
        "gene_name": "FBXW5",
        "organism": "Human",
        "refseq_name": "F-box/WD repeat-containing protein 5",
        "refseq_ac": "NP_061871",
        "gene_names_uniprotkb": "FBXW5; FBW5; PP3971",
        "gene_names_refseq": "FBXW5; Fbw5",
        "protein_names_uniprotkb": "F-box/WD repeat-containing protein 5; F-box and WD-40 domain-containing protein 5",
        "protein_names_refseq": "F-box and WD-40 domain-containing protein 5; F-box/WD repeat-containing protein 5; WD repeat-containing F-box protein FBW5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54461);  (R-HSA-390471);  (R-HSA-8951664);  (R-HSA-983168)",
        "pathway_count": 4,
        "publication_count": 199,
        "publication_id_list": "10.1101/2023.09.13.557529;10535940;10597293;10811609;10878807;10973499;11062501;11069780;11237011;11259415;11292861;11292862;11350924;11454738;11585840;11733065;11961546;12101228;12186903;12502735;12504025;12504026;12526791;12538644;12609982;12646216;12682069;12759363;12816948;14690597;14734113;14757770;15224091;15224092;15282312;15361859;15367669;15498874;15537541;15571818;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16595681;16647857;16707496;16790436;16849449;16943200;16954532;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18381890;18662542;18775313;18775504;18776931;18805092;18826954;18851830;18926707;18991276;19011634;19028597;19232515;19250909;19321346;19352404;19452197;19489725;19617556;19748355;19851334;19874575;19940261;21098288;21447816;21463634;21725316;21778237;21863050;21940857;21995946;22306028;22466964;22537386;2261476;22959436;23186163;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23747015;23912815;23986495;24076655;24366543;24636985;24715725;24756126;24793695;24793696;25314029;25342745;25349211;25355947;25418920;25467444;25531226;26154972;26344709;26460955;26632597;26758079;26811146;26906416;26992070;27030794;27222660;27565346;27920218;28063628;28115426;28218747;28228285;28649982;28832583;28834231;28904123;29153394;29242379;29393594;29437277;29493099;29508533;29557506;29632711;29786170;30379171;30410026;30429286;30524438;30610225;31217245;31844290;32005965;32157095;32265295;32284348;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33444648;33691108;33912179;33936100;33968037;34087483;34171305;34368969;34509645;34932366;35051231;35318648;35561310;35580925;36241641;36284347;9380723;9668046;9790970;9819444;9887101;9891082",
        "class_list": "",
        "function": "Results indicate that FBW5-DDB1-CUL4-ROC1 is an E3 ubiquitin ligase regulating TSC2 protein stability and TSC complex turnover., [RefSeq, PubMed]; SCF(Fbxw5) targets kinesin-13 proteins to facilitate ciliogenesis., [RefSeq, PubMed]; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDZ6;Q59ET5;Q5SPZ8;Q5SPZ9;Q5SQ00;Q5SQ02;Q5SQ03;Q5SQ04;Q8WY79;Q96GJ6;Q9BSU8;Q9H6A8;Q9HBQ6;Q9NSZ3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex;GO:0080008 Cul4-RING E3 ubiquitin ligase complex",
        "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0060271 cilium assembly;GO:0016567 protein ubiquitination;GO:0007088 regulation of mitotic nuclear division",
        "synthesized_glycan_count": 0,
        "hit_score": 20.4,
        "record_id": "Q969U6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZMM2-1",
        "uniprot_id": "ATL5_HUMAN",
        "mass": 53193.0,
        "length": 481,
        "protein_name": "ADAMTS-like protein 5",
        "gene_name": "ADAMTSL5",
        "organism": "Human",
        "refseq_name": "ADAMTS-like protein 5 isoform 2 precursor",
        "refseq_ac": "NP_998769",
        "gene_names_uniprotkb": "ADAMTSL5; THSD6",
        "gene_names_refseq": "ADAMTSL5; THSD6",
        "protein_names_uniprotkb": "ADAMTS-like protein 5; ADAMTSL-5; Thrombospondin type-1 domain-containing protein 6",
        "protein_names_refseq": "ADAMTS-like protein 5 isoform 2 precursor; ADAMTS-like protein 5; ADAMTSL-5; thrombospondin type-1 domain-containing protein 6; thrombospondin, type I, domain containing 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:339366);  (R-HSA-5083635);  (R-HSA-5173214)",
        "pathway_count": 3,
        "publication_count": 22,
        "publication_id_list": "11067851;11237011;16464858;18720094;19796186;19851296;20198315;22588082;23010571;23889335;25544610;26621454;28292214;28655516;30459171;32938616;33141586;34580106;35051231;35587154;38253038;38524140",
        "class_list": "",
        "function": "ADAMTSL5 could have a role in modulating microfibril functions., [RefSeq, PubMed]; Chemoresistant B-ALL patients are associated with increased methylation in ADAMTSL5 and CDH11., [RefSeq, PubMed]; Circular RNA circPFKP suppresses the proliferation and metastasis of gastric cancer cell via sponging miR-644 and regulating ADAMTSL5 expression., [RefSeq, PubMed]; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM)., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DXK7;Q8IW95",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008201 heparin binding;GO:0050436 microfibril binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0001527 microfibril",
        "go_biological_process": "GO:0030198 extracellular matrix organization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q6ZMM2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q53ET0-1",
        "uniprot_id": "CRTC2_HUMAN",
        "mass": 73302.0,
        "length": 693,
        "protein_name": "CREB-regulated transcription coactivator 2",
        "gene_name": "CRTC2",
        "organism": "Human",
        "refseq_name": "CREB-regulated transcription coactivator 2",
        "refseq_ac": "NP_859066",
        "gene_names_uniprotkb": "CRTC2; TORC2",
        "gene_names_refseq": "CRTC2; TORC-2; TORC2",
        "protein_names_uniprotkb": "CREB-regulated transcription coactivator 2; TORC-2; Transducer of CREB protein 2; Transducer of regulated cAMP response element-binding protein 2",
        "protein_names_refseq": "CREB-regulated transcription coactivator 2; transducer of regulated cAMP response element-binding protein (CREB) 2",
        "tax_id": 9606,
        "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:200186);  (R-HSA-2151201);  (R-HSA-9707616);  (R-HSA-9931509)",
        "pathway_count": 4,
        "publication_count": 159,
        "publication_id_list": "10198158;10381560;10412986;10643692;10713165;11237011;11340167;11387216;11809803;12130498;12356737;12374852;12377782;12511571;12563009;12745923;14506290;14536081;15175654;15454081;15589160;15665827;15684387;15761026;16079181;16079853;16148943;16306228;16308421;16684769;16788062;16809310;16817901;16890199;16908542;16911507;16964243;16980408;17031457;17210223;17437997;17715127;17923681;17950019;18006707;18037887;18215119;18220336;18323454;18343819;18348280;18626018;18669648;18680753;18707149;18767875;19001277;19254569;19356719;19413330;19417006;19651622;19690332;19710360;19951946;20068231;20551288;20577053;20581824;20817722;21479263;21628546;21892142;23186163;23301498;23584792;24196956;24275569;24715725;24755741;2539258;25892735;26154972;26811146;27754849;27846572;27920218;28111073;28832583;28904123;29237092;29242379;29351928;29393594;29508533;29557506;29632711;29786170;30059200;30429286;30611118;30779550;31092671;31355336;31492838;31748741;31844290;32157095;32161166;32354867;32357974;32387766;32502341;32574038;32695117;32897882;32938616;32938750;33000695;33013689;33141586;33214551;33298915;3345742;33912179;33968037;33981976;34019948;34087483;34171305;34211107;34509645;34846842;35051231;35132862;35254053;35289036;35318648;35504112;35513511;35580925;36010968;37541260;38665916;38838015;39302247;39531497;39534244;7629110;7799916;8108407;8333869;8415693;8622974;8887638;9079689;9144434;9178750;9286700",
        "class_list": "",
        "function": "Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer., [RefSeq, PubMed]; These results strongly suggest that TORCs play a key role in linking these external signals to the transcriptional program of adaptive mitochondrial biogenesis by activating PGC-1alpha gene transcription., [RefSeq, PubMed]; This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]., [RefSeq]; Thus, both TORC1/2 and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax., [RefSeq, PubMed]; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 13,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 13,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 13,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 49,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 16,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6UUV8;Q7Z3X7;Q8N332",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008140 cAMP response element binding protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051289 protein homotetramerization;GO:0071320 cellular response to cAMP;GO:0006094 gluconeogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 17.5,
        "record_id": "Q53ET0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q969S9-1",
        "uniprot_id": "RRF2M_HUMAN",
        "mass": 86601.0,
        "length": 779,
        "protein_name": "Ribosome-releasing factor 2, mitochondrial",
        "gene_name": "GFM2",
        "organism": "Human",
        "refseq_name": "ribosome-releasing factor 2, mitochondrial isoform 4",
        "refseq_ac": "NP_001268231",
        "gene_names_uniprotkb": "GFM2; EFG2; MSTP027",
        "gene_names_refseq": "EF-G2mt; EFG2; GFM2; MRRF2; MST027; MSTP027; RRF2mt; RRF2; RRF; hEFG2; mEF-G 2",
        "protein_names_uniprotkb": "Ribosome-releasing factor 2, mitochondrial; 3.6.5.-; EF-G2mt; Elongation factor G 2, mitochondrial; Elongation factor G2; RRF2mt; hEFG2; mEF-G 2",
        "protein_names_refseq": "G elongation factor mitochondrial 2; mitochondrial elongation factor G2; mitochondrial ribosome recycling factor 2; mitochondrial ribosome-releasing factor 2; ribosome releasing factor 2; ribosome-releasing factor 2, mitochondrial isoform 4; ribosome-releasing factor 2, mitochondrial",
        "tax_id": 9606,
        "disease": "combined oxidative phosphorylation deficiency 39 (Disease Ontology:DOID:0111475)",
        "pathway": " (hsa:84340);  (R-HSA-5419276)",
        "pathway_count": 2,
        "publication_count": 50,
        "publication_id_list": "11237011;11735030;17803939;18429816;18753147;18782833;19716793;20186120;20877624;22172991;22700954;22719265;23301498;25233460;25418920;26016410;26811146;26992070;27600516;28218747;28649982;28855257;28904123;29075935;29437277;29557506;30410026;31530632;31844290;32157095;32161166;32357974;32387766;32488085;32502341;32938616;33141586;33298915;33878294;33968037;34087483;34171305;34509645;35051231;35580925;36010968;36302763;36596788;37141370;40914422",
        "class_list": "",
        "function": "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis., [RefSeq, PubMed]; Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]., [RefSeq]; GFM2 mutations could be causative of a phenotype of Leigh syndrome with arthrogryposis multiplex congenita., [RefSeq, PubMed]; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis (PubMed:19716793, PubMed:33878294). Acts in collaboration with MRRF (PubMed:19716793, PubMed:33878294). Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts (PubMed:33878294). GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit (PubMed:19716793). Not involved in the GTP-dependent ribosomal translocation step during translation elongation (PubMed:19716793)., [UniProtKB, PubMed, PubMed]; Myoblasts isolated from the MELAS patients show A3243G mutation in tRNALeu(UUR) produces a severe respiratory chain deficiency and this phenotype can be partially suppressed by overexpression of EFTu and EFG2., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; These findings constitute the first reported phenotype associated with SNPs in the EF-G2mt gene and implicate the human EF-G2mt gene as a pharmacogenetic candidate gene for statin toxicity in humans, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_snv": 9,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "glyco_site_count": 0,
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        "secondary_ac_list": "A0AR28;Q8N6D8;Q8WYI0;Q9H6Z1",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4;3.1.1.29;2.7.11.1;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0032790 ribosome disassembly;GO:0070126 mitochondrial translational termination;GO:0032543 mitochondrial translation;GO:0006412 translation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q969S9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99728-1",
        "uniprot_id": "BARD1_HUMAN",
        "mass": 86648.0,
        "length": 777,
        "protein_name": "BRCA1-associated RING domain protein 1",
        "gene_name": "BARD1",
        "organism": "Human",
        "refseq_name": "BRCA1-associated RING domain protein 1 isoform 1",
        "refseq_ac": "NP_000456",
        "gene_names_uniprotkb": "BARD1",
        "gene_names_refseq": "BARD1",
        "protein_names_uniprotkb": "BRCA1-associated RING domain protein 1; 2.3.2.27; BARD-1; RING-type E3 ubiquitin transferase BARD1",
        "protein_names_refseq": "BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1 isoform 1; BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1",
        "tax_id": 9606,
        "disease": "breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); retinal degeneration (Disease Ontology:DOID:8466)",
        "pathway": " (hsa:580);  (R-HSA-5685938);  (R-HSA-5685942);  (R-HSA-5689603);  (R-HSA-5689901);  (R-HSA-5693537);  (R-HSA-5693554);  (R-HSA-5693565);  (R-HSA-5693568);  (R-HSA-5693571);  (R-HSA-5693579);  (R-HSA-5693607);  (R-HSA-5693616);  (R-HSA-6804756);  (R-HSA-69473);  (R-HSA-9663199);  (R-HSA-9699150);  (R-HSA-9701192);  (R-HSA-9704331);  (R-HSA-9704646);  (R-HSA-9709570);  (R-HSA-9709603)",
        "pathway_count": 22,
        "publication_count": 420,
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        "class_list": "",
        "function": "BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution., [RefSeq, PubMed]; BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes., [RefSeq, PubMed]; E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Germline BARD1 variants predispose to mesothelioma by impairing DNA repair and calcium signaling., [RefSeq, PubMed]; Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection. Erratum:[Nature. 2025 Oct;646(8086):E14. doi: 10.1038/s41586-025-09636-1. PMID: 40983763], [RefSeq, PubMed]; Promotion of DNA end resection by BRCA1-BARD1 in homologous recombination., [RefSeq, PubMed]; This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
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        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 1,
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        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
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        "reported_snv": 56,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F6MDH7;F6MDH8;F6MDH9;O43574;Q53SS5",
        "ec_number_list": "2.7.11.1;2.3.2.27;2.3.2.26;2.1.1.357;6.5.1.1;2.7.7.7;3.1.11.-;3.4.19.-;3.1.-.-;5.6.2.4;2.3.2.23;2.3.2.-;3.6.4.-;5.6.2.1;3.4.19.12;3.6.-.-;2.3.1.48;2.3.1.-;3.1.22.-;3.1.11.2;5.6.2.3;5.6.2.-",
        "go_molecular_function": "GO:0061649 ubiquitin-modified histone reader activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0070531 BRCA1-A complex",
        "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043065 positive regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 42.3,
        "record_id": "Q99728-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P48751-1",
        "uniprot_id": "B3A3_HUMAN",
        "mass": 135791.0,
        "length": 1232,
        "protein_name": "Anion exchange protein 3",
        "gene_name": "SLC4A3",
        "organism": "Human",
        "refseq_name": "anion exchange protein 3 isoform 2",
        "refseq_ac": "NP_001313488",
        "gene_names_uniprotkb": "SLC4A3; AE3",
        "gene_names_refseq": "AE3; CAE3/BAE3; SLC2C; SLC4A3; SQT7",
        "protein_names_uniprotkb": "Anion exchange protein 3; AE 3; Anion exchanger 3; CAE3/BAE3; Cardiac/brain band 3-like protein; Neuronal band 3-like protein; Solute carrier family 4 member 3",
        "protein_names_refseq": "Anion exchanger 3, neuronal; anion exchange protein 3 isoform 2; anion exchange protein 3; cardiac/brain band 3-like protein; neuronal band 3-like protein; solute carrier family 4 (anion exchanger), member 3",
        "tax_id": 9606,
        "disease": "short QT syndrome (Disease Ontology:DOID:0050793); anemia (Disease Ontology:DOID:2355); short QT syndrome 7 (MONDO:MONDO:0859368)",
        "pathway": " (hsa:6508);  (R-HSA-425381)",
        "pathway_count": 2,
        "publication_count": 34,
        "publication_id_list": "10347222;10362779;10545938;10978526;11237011;11305939;11739292;11788353;17924679;18319254;18510355;20068231;24472682;25576336;25645385;2594752;28832583;29167417;29557506;3015590;31844290;33968037;34509645;35051231;35580925;36806574;39033175;7506871;7530501;7923606;8206915;9235899;9312167;9651366",
        "class_list": "",
        "function": "Genetic analysis identifies the SLC4A3 anion exchanger as a major gene for short QT syndrome., [RefSeq, PubMed]; Identify a missense mutation in the anion exchanger (AE3)-encoding SLC4A3 gene in two unrelated families with short QT syndrome. The mutation causes reduced surface expression of AE3 and reduced membrane bicarbonate transport. Publication Status: Online-Only, [RefSeq, PubMed]; Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:29167417, PubMed:7923606). May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (PubMed:29167417)., [UniProtKB, PubMed, PubMed]; The protein encoded by this gene is a plasma membrane anion exchange protein. The encoded protein has been found in brain, heart, kidney, small intestine, and lung. [provided by RefSeq, May 2016]., [RefSeq]; The structural insight into the functional modulation of human anion exchanger 3. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8L2;A8K1Q9;B7ZVX6;B9EGD1;Q6YIQ9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0015106 bicarbonate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity;GO:0008509 monoatomic anion transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0055085 transmembrane transport;GO:0061337 cardiac conduction;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH;GO:0086001 cardiac muscle cell action potential",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "P48751-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86XK2-1",
        "uniprot_id": "FBX11_HUMAN",
        "mass": 103585.0,
        "length": 927,
        "protein_name": "F-box only protein 11",
        "gene_name": "FBXO11",
        "organism": "Human",
        "refseq_name": "F-box only protein 11 isoform 4",
        "refseq_ac": "NP_001177203",
        "gene_names_uniprotkb": "FBXO11; FBX11; PRMT9; UG063H01; VIT1",
        "gene_names_refseq": "FBX11; FBXO11; IDDFBA; UBR6; UG063H01; VIT1",
        "protein_names_uniprotkb": "F-box only protein 11; Protein arginine N-methyltransferase 9; VIT-1; Vitiligo-associated protein 1",
        "protein_names_refseq": "F-box only protein 11 isoform 4; F-box only protein 11; ubiquitin protein ligase E3 component n-recognin 6; vitiligo-associated protein 1; vitiligo-associated protein VIT-1",
        "tax_id": 9606,
        "disease": "intellectual developmental disorder with dysmorphic facies and behavioral abnormalities (Disease Ontology:DOID:0061129); stomach cancer (Disease Ontology:DOID:10534); otitis media (Disease Ontology:DOID:10754); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:80204);  (R-HSA-8951664);  (R-HSA-983168)",
        "pathway_count": 3,
        "publication_count": 210,
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        "class_list": "",
        "function": "FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA., [RefSeq, PubMed]; FBXO11 promotes the Neddylation (NEDD8) of p53 and inhibits its transcriptional activity, [RefSeq, PubMed]; FBXO11 variants are associated with intellectual disability and variable clinical manifestation in Chinese affected individuals., [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1 (PubMed:17098746, PubMed:22113614, PubMed:23478441, PubMed:23478445, PubMed:23892434, PubMed:24613396, PubMed:24968003, PubMed:25827072, PubMed:29059170). The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells (PubMed:22113614). The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit (PubMed:23478441, PubMed:23478445). The SCF(FBXO11) complex also catalyzes ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (PubMed:25827072, PubMed:29059170). Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity (PubMed:17098746). Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis (PubMed:33156908). Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks (PubMed:33156908). Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta (PubMed:33156908). Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome (PubMed:37279268). Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis (PubMed:36897010). Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1 (PubMed:36897010)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The FBXO11 gene is the human homologue of the gene mutated in the novel deaf mouse mutant jeff (Jf), a single gene model of otitis media. FBXO11 gene for association with chronic otitis media with effusion. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]., [RefSeq]",
        "predicted_glycosites": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
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        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 0,
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        "secondary_ac_list": "A1L491;Q52ZP1;Q53EP7;Q53RT5;Q8IXG3;Q96E90;Q9H6V8;Q9H9L1;Q9NR14;Q9UFK1;Q9UHI1;Q9UKC2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016274 protein-arginine N-methyltransferase activity;GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0042981 regulation of apoptotic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0010719 negative regulation of epithelial to mesenchymal transition",
        "synthesized_glycan_count": 0,
        "hit_score": 21.1,
        "record_id": "Q86XK2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q02750-1",
        "uniprot_id": "MP2K1_HUMAN",
        "mass": 43439.0,
        "length": 393,
        "protein_name": "Dual specificity mitogen-activated protein kinase kinase 1",
        "gene_name": "MAP2K1",
        "organism": "Human",
        "refseq_name": "dual specificity mitogen-activated protein kinase kinase 1 isoform 1",
        "refseq_ac": "NP_002746",
        "gene_names_uniprotkb": "MAP2K1; MEK1; PRKMK1",
        "gene_names_refseq": "CFC3; MAP2K1; MAPKK1; MEK1; MEL; MKK1; PRKMK1",
        "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 1; 2.7.12.2; ERK activator kinase 1; MAP kinase kinase 1; MAPK/ERK kinase 1; MAPKK 1; MEK 1; MKK1",
        "protein_names_refseq": "ERK activator kinase 1; MAPK/ERK kinase 1; MAPKK 1; MEK 1; dual specificity mitogen-activated protein kinase kinase 1 isoform 1; dual specificity mitogen-activated protein kinase kinase 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)",
        "tax_id": 9606,
        "disease": "cardiofaciocutaneous syndrome (Disease Ontology:DOID:0060233); RASopathy (Disease Ontology:DOID:0080690); cardiofaciocutaneous syndrome 3 (Disease Ontology:DOID:0111462); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); prostate adenocarcinoma (Disease Ontology:DOID:2526); high grade glioma (Disease Ontology:DOID:3070); lung adenocarcinoma (Disease Ontology:DOID:3910); ovarian carcinoma (Disease Ontology:DOID:4001); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); melorheostosis (Disease Ontology:DOID:4253); renal cell carcinoma (Disease Ontology:DOID:4450); small intestine adenocarcinoma (Disease Ontology:DOID:4906); cataract (Disease Ontology:DOID:83)",
        "pathway": " (hsa:5604);  (R-HSA-110056);  (R-HSA-170968);  (R-HSA-445144);  (R-HSA-5210891);  (R-HSA-5673000);  (R-HSA-5674135);  (R-HSA-5674499);  (R-HSA-5684264);  (R-HSA-6802946);  (R-HSA-6802948);  (R-HSA-6802952);  (R-HSA-6802955);  (R-HSA-9649948);  (R-HSA-9652169);  (R-HSA-9656223)",
        "pathway_count": 16,
        "publication_count": 373,
        "publication_id_list": "10.1101/2023.09.13.557529;10037701;10205168;10209122;10359597;10409742;10567369;10611478;10629055;10712905;10725339;10818153;10891492;11032810;11104681;11158290;11237011;11278445;11325826;11466412;11494123;11684694;11741534;11756411;11802164;11802165;11948406;12040181;12068308;12244094;12456642;12473660;12479806;12482991;12506122;12551923;12586835;12594221;12609978;12667451;12676795;1281467;12832462;12832465;12876277;12932319;12932339;1438214;14530258;14636584;14654779;14673179;14718570;14737111;14970219;14993270;15035987;15118098;15169888;15175348;15239952;15258589;15260967;15337774;15466214;15466476;15467451;15520807;15543157;15547943;15596135;15597056;15630448;15664191;15710605;15711535;15778223;15899852;16041367;16093354;16129686;16135787;16294014;16364920;16439621;1644824;16508002;16537381;16630891;16702958;16728640;16806191;16815847;16879721;16939974;17018604;17097642;17101779;17145850;17178906;17234158;17253643;17314031;17496912;17563371;17603482;17603483;17667937;17880056;17928366;18042262;18060073;18222703;18287029;18294816;18329369;18413255;18555990;18559533;18562239;18593598;18617556;18632602;18662992;18691976;18951019;18974108;19019675;19049963;19091303;19158341;19161339;19219045;19242111;19279408;19447520;19467855;19541618;19565474;19684605;19706763;19727074;19930650;19933846;20052757;20058876;20130576;20141835;20179705;20354455;20358587;20526349;20621728;20674547;20679487;20818844;20820846;20858867;20956560;21107323;2114169;21310613;21316218;21383288;21424530;21441104;21441910;21475805;21514245;21639808;21779493;21779496;21784453;21793567;21993244;22043453;22065583;22113612;22177953;22197931;22292133;22356324;22395615;22510884;22569528;22589270;22592532;22745804;22826437;2295682;22988300;23171796;23288408;23319808;23352452;23360980;23453624;23583981;23614898;23653349;23667175;23680146;23735655;23746211;23863182;23875798;23906342;23934108;23954936;23993095;24121058;24121489;24135138;24202393;24211266;24241536;24265153;24345920;24347342;24651010;24715725;24746704;24937142;24957944;25049390;25182392;25195011;25204415;25313996;25418920;25435214;25468936;25505266;25576301;25907612;25965804;25974265;26195727;26214590;26343583;26811146;26992070;27169363;27227380;27264673;27503831;27542844;27846572;27920218;27999210;28063628;28076410;28082416;28218747;28289718;28666118;28832583;28834231;28904123;28939558;28984291;29242379;29393594;29433126;29461827;29467321;29493099;29508533;29557506;29632046;29632711;29643386;29753091;29786170;29804890;29968772;30034615;30315122;30429286;30524438;30794926;30971268;31217245;31530632;31844290;31848261;32157095;32265295;32350084;32357974;32387766;32721402;3287375;32897882;32938616;32983136;33043033;33123756;33298915;33592498;33808483;33968037;34019948;34357683;34405274;34509645;34725712;34779126;35051231;35132862;35154160;35251023;35318648;35580925;35670744;36215666;36284347;37357851;37565534;37579140;37869794;40914422;6328915;7542586;7565670;7565795;7624324;7651428;7731720;7744815;7806500;7854123;7873542;7929275;7935411;8013650;8019005;8034665;8051079;8051159;8114697;8131746;8157000;8226933;8387505;8388392;8394352;8509458;8521512;8521513;8521514;8592152;8621729;8631303;8637718;8876196;8946910;8952507;9020159;9182757;9234708;9351825;9396761;9535861;9560161;9563949;9689060;9703991;9733512;9779990;9823899;9858547;9950430",
        "class_list": "",
        "function": "Activating mutations drive human MEK1 kinase using a gear-shifting mechanism., [RefSeq, PubMed]; Clinical associations of BRAF and MAP2K1 mutations in pediatric Langerhans cell histiocytosis: When 1 + 1 = 3., [RefSeq, PubMed]; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis., [UniProtKB, PubMed, PubMed, PubMed]; Evolutionary history of MEK1 illuminates the nature of deleterious mutations., [RefSeq, PubMed]; MAP2K1-mutated melanocytic tumors have reproducible histopathologic features and share similarities with melanocytic tumors with BRAF V600E mutations. Review article, [RefSeq, PubMed]; The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
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        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 45,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 43,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 14,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.10.1;2.3.2.27;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;3.6.5.2;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.32;2.7.1.82;2.7.10.4;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;3.6.4.-;3.1.3.48;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;2.7.1.107;2.7.1.94;2.7.1.138;3.6.5.-;2.7.7.-;2.7.7.19;1.14.11.65;3.1.31.1;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0030295 protein kinase activator activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:2000641 regulation of early endosome to late endosome transport;GO:0045933 positive regulation of muscle contraction;GO:2001171 positive regulation of ATP biosynthetic process;GO:0003056 regulation of vascular associated smooth muscle contraction;GO:0006935 chemotaxis",
        "synthesized_glycan_count": 0,
        "hit_score": 37.8,
        "record_id": "Q02750-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00233-1",
        "uniprot_id": "PSMD9_HUMAN",
        "mass": 24682.0,
        "length": 223,
        "protein_name": "26S proteasome non-ATPase regulatory subunit 9",
        "gene_name": "PSMD9",
        "organism": "Human",
        "refseq_name": "26S proteasome non-ATPase regulatory subunit 9 isoform 2",
        "refseq_ac": "NP_001248329",
        "gene_names_uniprotkb": "PSMD9",
        "gene_names_refseq": "PSMD9; Rpn4; p27",
        "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 9; 26S proteasome regulatory subunit p27",
        "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 9 isoform 2; 26S proteasome non-ATPase regulatory subunit 9; 26S proteasome regulatory subunit p27; homolog of rat Bridge 1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 9; proteasome 26S non-ATPase regulatory subunit 9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5715);  (R-HSA-9907900)",
        "pathway_count": 2,
        "publication_count": 51,
        "publication_id_list": "10.1101/2023.09.13.557529;10973495;11237011;15831487;16251969;16712791;16990800;17189198;17540904;17948026;19490896;20068231;20471946;23301498;23481700;26375851;27920218;28063628;28263418;28442575;28510447;28598414;28832583;28834231;29242379;29632046;30779550;30833945;31844290;31848261;32157095;32350084;32387766;32502341;32938616;33717175;33968037;33981976;34019948;34357683;34561969;35051231;35132862;35251023;35580925;36524506;37485655;37665644;38665916;38745188;9653651",
        "class_list": "",
        "function": "Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Comprehensive analysis of PSMD family members and validation of PSMD9 as a potential therapeutic target in human glioblastoma., [RefSeq, PubMed]; PSMD9 is linked to T2D age of onset, years of isolated and combined insulin therapy, irregular menses, and hot flashes., [RefSeq, PubMed]; PSMD9 promotes the malignant progression of hepatocellular carcinoma by interacting with c-Cbl to activate EGFR signaling and recycling. Erratum:[J Exp Clin Cancer Res. 2024 Oct 18;43(1):287. doi: 10.1186/s13046-024-03209-2. PMID: 39420369] Publication Status: Online-Only, [RefSeq, PubMed]; The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]., [RefSeq]; The interaction network of the proteasome assembly chaperone PSMD9 regulates proteostasis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RD35;G3V1Q6;Q9BQ42",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0043425 bHLH transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005838 proteasome regulatory particle",
        "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0045893 positive regulation of DNA-templated transcription;GO:0046676 negative regulation of insulin secretion;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070682 proteasome regulatory particle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "O00233-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A1A5D9-1",
        "uniprot_id": "BICL2_HUMAN",
        "mass": 56834.0,
        "length": 508,
        "protein_name": "BICD family-like cargo adapter 2",
        "gene_name": "BICDL2",
        "organism": "Human",
        "refseq_name": "BICD family-like cargo adapter 2",
        "refseq_ac": "NP_001096645",
        "gene_names_uniprotkb": "BICDL2; BICDR2; CCDC64B",
        "gene_names_refseq": "BICDL2; BICDR-2; BICDR2; CCDC64B",
        "protein_names_uniprotkb": "BICD family-like cargo adapter 2; BICD-related protein 2; BICDR-2; Bicaudal D-related protein 2; Coiled-coil domain-containing protein 64B",
        "protein_names_refseq": "BICD family-like cargo adapter 2; BICD-related protein 2; bicaudal D-related protein 2; coiled-coil domain containing 64B; coiled-coil domain-containing protein 64B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:146439)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;25576301;28411811;29557506;30192525;30779550;33981976;34087483",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q658L9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031267 small GTPase binding",
        "go_cellular_component": "",
        "go_biological_process": "GO:0047496 vesicle transport along microtubule;GO:0055107 Golgi to secretory granule transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "A1A5D9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UY14-1",
        "uniprot_id": "ATL4_HUMAN",
        "mass": 116545.0,
        "length": 1074,
        "protein_name": "ADAMTS-like protein 4",
        "gene_name": "ADAMTSL4",
        "organism": "Human",
        "refseq_name": "ADAMTS-like protein 4 isoform 3 precursor",
        "refseq_ac": "NP_001275536",
        "gene_names_uniprotkb": "ADAMTSL4; PP1396; PRO34012; TSRC1",
        "gene_names_refseq": "ADAMTSL-4; ADAMTSL4; ECTOL2; TSRC1",
        "protein_names_uniprotkb": "ADAMTS-like protein 4; ADAMTSL-4; Thrombospondin repeat-containing protein 1",
        "protein_names_refseq": "ADAMTS-like protein 4 isoform 3 precursor; ADAMTS-like protein 4; thrombospondin repeat-containing protein 1",
        "tax_id": 9606,
        "disease": "autosomal recessive isolated ectopia lentis 2 (Disease Ontology:DOID:0111149); ectopia lentis with ectopia of pupil (Disease Ontology:DOID:0111648); lens disease (Disease Ontology:DOID:110); craniosynostosis (Disease Ontology:DOID:2340)",
        "pathway": " (hsa:54507);  (R-HSA-5083635);  (R-HSA-5173214)",
        "pathway_count": 3,
        "publication_count": 41,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;11067851;11237011;12706885;12975309;15498874;16335952;16364318;16464858;18720094;19139490;19200529;19796186;20702823;21989719;22588082;23584533;23889335;25544610;28514659;29557506;29741879;30459171;31611695;31844290;32157095;32350084;32938616;32983136;33123756;33592498;33968037;34357683;35042684;35051231;35251023;35580925;36208099;37074911;39278391",
        "class_list": "",
        "function": "Biallelic ADAMTSL4 variants in a Chinese cohort of congenital ectopia lentis: Implications for genotype-phenotype relationships., [RefSeq, PubMed]; Mutations in ADAMTSL4 are responsible for autosomal-recessive simple ectopia lentis and this proteins affectsthe development of the zonular fibers., [RefSeq, PubMed]; Mutations in ADAMTSL4 cause a unique form of autosomal-recessive congenital ectopia lentis., [RefSeq, PubMed]; Novel ADAMTSL4 gene mutations in Chinese patients with isolated ectopia lentis., [RefSeq, PubMed]; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis., [UniProtKB, PubMed, PubMed]; This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Sep 2014]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 17,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 17,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 17,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 53,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 20,
        "disease_count": 4,
        "glyco_site_count": 22,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RTT0;F8WAD0;Q5T5F7;Q6IPM6;Q8N643;Q9HBS6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0031012 extracellular matrix;GO:0005614 interstitial matrix",
        "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "Q6UY14-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51572-1",
        "uniprot_id": "BAP31_HUMAN",
        "mass": 27992.0,
        "length": 246,
        "protein_name": "B-cell receptor-associated protein 31",
        "gene_name": "BCAP31",
        "organism": "Human",
        "refseq_name": "B-cell receptor-associated protein 31 isoform b",
        "refseq_ac": "NP_001132913",
        "gene_names_uniprotkb": "BCAP31; BAP31; DXS1357E",
        "gene_names_refseq": "6C6-AG; BAP31; BCAP31; CDM; DDCH; DELXQ28; DXS1357E; MICRODELXq28",
        "protein_names_uniprotkb": "B-cell receptor-associated protein 31; 6C6-AG tumor-associated antigen; BCR-associated protein 31; Bap31; Protein CDM; p28",
        "protein_names_refseq": "6C6-AG tumor-associated antigen; B-cell receptor-associated protein 31 isoform b; BCR-associated protein Bap31; p28 Bap31",
        "tax_id": 9606,
        "disease": "deafness, dystonia, and cerebral hypomyelination (Disease Ontology:DOID:0112123); sensorineural hearing loss (Disease Ontology:DOID:10003)",
        "pathway": " (hsa:10134);  (R-HSA-111465);  (R-HSA-75153);  (R-HSA-8980692);  (R-HSA-983170);  (R-HSA-9833110)",
        "pathway_count": 6,
        "publication_count": 329,
        "publication_id_list": "10037681;10064069;10200466;10232922;10453075;10490026;10490598;10523665;10523675;10526156;10579713;10600378;10619026;10699171;10777614;10825291;10873388;10958671;10982397;11042173;11058585;11085924;11106668;11160214;11163199;11207612;11237011;11278797;11313965;11373293;11396949;11431473;11432776;11463840;11466336;11514579;11561007;11606631;11607032;11672528;11680691;11689693;11704860;11741893;11804589;11804590;11884391;11912491;11917123;11992258;12071859;12093360;12107159;12195014;12221077;12221096;12436109;12436110;12531887;12645939;12650940;12668660;12857875;12877655;14512443;14681859;14718384;14976261;15023524;15024066;15064355;15104674;15107133;15254227;15286279;15302923;15342493;15485661;15601624;15611138;15850391;15866170;15927284;16112081;16116428;16123041;16184169;16217026;16465444;16467373;16473882;16519628;16630611;16776779;16777452;16777849;16862148;16896804;16914516;16983089;17056546;17077126;17088086;17297457;17316621;17562871;17656363;17702745;17765681;17804252;17932950;17942708;17976533;18158243;18218625;18287538;18420935;18829452;19119025;19193869;19261456;19342655;19361863;19426129;19494238;19575639;19605563;19635168;19673492;19713215;19851281;20030946;20068231;20101212;20112406;2038058;20400958;20410276;20591975;20605430;20628200;20660154;21050182;21148482;21351730;21454492;21565175;21699497;21865595;21936715;22090124;22096251;22298643;22305756;22673745;22862954;22898188;22911862;22992742;23200924;23255595;23434736;23481700;23572525;23870313;23967155;24011989;24086303;24128008;24196833;24259668;24335996;24352656;24366607;2450918;24556848;24714562;24933155;25211221;25418920;25469497;25576301;25631089;25645385;25704760;25854864;26102500;26154972;26371245;26375851;26529257;26728094;26811146;26887924;26929215;26992070;27145964;27216196;27481945;27600516;27862975;27907150;27920218;27986909;28063628;28112683;28196833;28228285;28584191;28649982;28832583;28834231;28904123;29146911;29242379;29314611;29393594;29493099;29508533;29557506;29632046;29786170;30315122;30429286;30444036;30484775;30524438;30779550;30833945;31105010;31154438;31206022;31222486;31530632;31844290;31848261;31871319;31937595;31998317;32157095;32203420;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34405274;34509645;34725712;35051231;35251023;35318648;35561310;35580925;35874702;36010968;36102648;36215666;36241641;36284347;37938771;38348718;38474195;38665916;38791141;7479768;7642652;7673236;7721814;7753201;7806238;7876241;8021274;8342042;8537347;8543060;8571126;8612576;8617235;8643598;8649427;8662891;8706661;8756646;8769096;8807639;8810315;8816443;8939998;8976194;9013646;9111050;9113980;9252332;9305890;9325343;9334338;9396746;9418861;9431985;9490638;9497316;9535835;9548756;9605141;9659915;9670022;9792683;9822605;9829970;9973322",
        "class_list": "",
        "function": "BAP31 Promotes Angiogenesis via Galectin-3 Upregulation in Neuroblastoma. Publication Status: Online-Only, [RefSeq, PubMed]; Contiguous deletion of the X-linked adrenoleukodystrophy gene (ABCD1) and DXS1357E: a novel neonatal phenotype similar to peroxisomal biogenesis disorders., [RefSeq, PubMed]; Functions as a chaperone protein (PubMed:18287538, PubMed:9396746). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:18287538, PubMed:9396746). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:18287538, PubMed:9396746). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022). May be involved in CASP8-mediated apoptosis (PubMed:10958671)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; NDC1 promotes hepatocellular carcinoma tumorigenesis by targeting BCAP31 to activate PI3K/AKT signaling., [RefSeq, PubMed]; P20BAP31 Induces Autophagy in Colorectal Cancer Cells by Promoting PERK-Mediated ER Stress. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the export of secreted proteins in the ER., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KQ79;D3DWV5;Q13836;Q96CF0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0042288 MHC class I protein binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007283 spermatogenesis;GO:0006915 apoptotic process;GO:0006626 protein targeting to mitochondrion;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport",
        "synthesized_glycan_count": 0,
        "hit_score": 33.2,
        "record_id": "P51572-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6L8H1-1",
        "uniprot_id": "KRA54_HUMAN",
        "mass": 25249.0,
        "length": 288,
        "protein_name": "Keratin-associated protein 5-4",
        "gene_name": "KRTAP5-4",
        "organism": "Human",
        "refseq_name": "keratin-associated protein 5-4 isoform 2",
        "refseq_ac": "NP_001012727",
        "gene_names_uniprotkb": "KRTAP5-4; KAP5.4; KRTAP5.4",
        "gene_names_refseq": "KRTAP5-4; KRTAP5.4",
        "protein_names_uniprotkb": "Keratin-associated protein 5-4; Keratin-associated protein 5.4; Ultrahigh sulfur keratin-associated protein 5.4",
        "protein_names_refseq": "keratin-associated protein 5-4 isoform 2; keratin-associated protein 5.4; ultrahigh sulfur keratin-associated protein 5.4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:387267);  (R-HSA-6805567)",
        "pathway_count": 2,
        "publication_count": 12,
        "publication_id_list": "11237011;15144888;15373777;16382671;1691188;1694855;1714783;17521629;23481192;2414304;25208914;9468612",
        "class_list": "",
        "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005882 intermediate filament",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q6L8H1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q76KP1-1",
        "uniprot_id": "B4GN4_HUMAN",
        "mass": 116513.0,
        "length": 1039,
        "protein_name": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1",
        "gene_name": "B4GALNT4",
        "organism": "Human",
        "refseq_name": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1",
        "refseq_ac": "NP_848632",
        "gene_names_uniprotkb": "B4GALNT4",
        "gene_names_refseq": "B4GALNT4",
        "protein_names_uniprotkb": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; 2.4.1.244; Beta-1,4-N-acetylgalactosaminyltransferase IV; Beta4GalNAc-T4; Beta4GalNAcT4; NGalNAc-T1",
        "protein_names_refseq": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; NGalNAc-T1; beta-1,4-N-acetyl-galactosaminyl transferase 4; beta-1,4-N-acetylgalactosaminyltransferase IV; beta1,4-N-acetylgalactosaminyltransferases IV; beta4GalNAc-T4; beta4GalNAcT4; betaGT4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:338707)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15044014;18048353;22722937;22722940;25858323;26992070;31611695;32161166;32253672;32938616;34171305;37217939",
        "class_list": "glycogene;glycosyltransferase",
        "function": "BetaGT3 and betaGT4, that are able to transfer GalNAc to GlcNAc in beta1,4-linkage display the necessary glycoprotein specificity in vivo., [RefSeq, PubMed]; Expression and Malignant Potential of B4GALNT4 in Esophageal Squamous Cell Carcinoma., [RefSeq, PubMed]; Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4., [RefSeq, PubMed]; Molecular cloning and characterization; specificity toward oligosaccharide acceptor substrates was quite similar to beta4GalNAc-T3 in vitro but the tissue distributions of the two enzymes were quite different, [RefSeq, PubMed]; Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4., [RefSeq, PubMed]; These results indicate that the expression of the LacdiNAc group is quite important for the suppression of malignancies of the MDA-MB-231 cells., [RefSeq, PubMed]; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans., [UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1433,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96LV2",
        "ec_number_list": "2.4.1.244",
        "go_molecular_function": "GO:0008376 acetylgalactosaminyltransferase activity;GO:0033842 N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity",
        "go_cellular_component": "GO:0032580 Golgi cisterna membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 865,
        "hit_score": 1.9,
        "record_id": "Q76KP1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14874-1",
        "uniprot_id": "BCKD_HUMAN",
        "mass": 46360.0,
        "length": 412,
        "protein_name": "Branched-chain alpha-ketoacid dehydrogenase kinase",
        "gene_name": "BCKDK",
        "organism": "Human",
        "refseq_name": "branched-chain alpha-ketoacid dehydrogenase kinase isoform b precursor",
        "refseq_ac": "NP_001116429",
        "gene_names_uniprotkb": "BCKDK",
        "gene_names_refseq": "BCKDKD; BCKDK; BDK",
        "protein_names_uniprotkb": "Branched-chain alpha-ketoacid dehydrogenase kinase; 2.7.11.1; 2.7.11.4; BCKDH kinase; BCKDHKIN; BDK; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial",
        "protein_names_refseq": "BCKD-kinase; BCKDH kinase; BCKDHKIN; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; branched chain alpha-ketoacid dehydrogenase kinase; branched chain ketoacid dehydrogenase kinase; branched-chain alpha-ketoacid dehydrogenase kinase isoform b precursor",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); branched-chain keto acid dehydrogenase kinase deficiency (Disease Ontology:DOID:0090126); oligospermia (Disease Ontology:DOID:14228)",
        "pathway": " (hsa:10295);  (R-HSA-70895);  (R-HSA-9912481)",
        "pathway_count": 3,
        "publication_count": 76,
        "publication_id_list": "10832746;10947204;11013134;11181649;11237011;11264579;11406611;11738050;11839747;12269802;12359132;12434311;12696021;13416257;14752098;15166214;1527093;15302860;15342248;15576032;16023992;16141215;17081983;17371050;18220336;18452278;18691976;19608861;19651622;20068231;20166139;22291014;22589535;22956686;23485643;24449431;26251176;26960196;26992070;28580691;28832583;28834231;29242379;29393594;29493099;29557506;29779826;29786170;30429286;3082934;31217245;31435015;31844290;32157095;32238881;32357974;32457292;32897882;33141586;33592498;33981976;34357683;35051231;35561310;35580925;3597357;36729635;37460470;37558654;38621458;6928646;7356336;8824301;9165094;9214289;9889013",
        "class_list": "",
        "function": "BCKDK regulates breast cancer cell adhesion and tumor metastasis by inhibiting TRIM21 ubiquitinate talin1. Publication Status: Online-Only, [RefSeq, PubMed]; Cross-talk between BCKDK-mediated phosphorylation and STUB1-dependent ubiquitination degradation of BCAT1 promotes GBM progression., [RefSeq, PubMed]; Employment of multidimensional heteronuclear NMR techniques to determine the structure and dynamics of the LBD of the human branched-chain alpha-keto acid dehydrogenase complex (hbLBD), [RefSeq, PubMed]; Serine/threonine-protein kinase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with PPM1K, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:24449431, PubMed:29779826, PubMed:37558654). Phosphorylates and inactivates mitochondrial BCKDH complex a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Associates with the E2 component of BCKDH complex and phosphorylates BCKDHA on Ser-337, leading to conformational changes that interrupt substrate channeling between E1 and E2 and inactivates the BCKDH complex (PubMed:29779826, PubMed:37558654). Phosphorylates ACLY on Ser-455 in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and glucogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxxE/D canonical motif (PubMed:29779826)., [UniProtKB, PubMed, PubMed, PubMed]; The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]., [RefSeq]; This publication is about the mouse gene but contains the 5' sequence of the human gene, including upstream open reading frame information., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MY43;Q6FGL4;Q96G95;Q96IN5",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;1.8.1.4;2.3.1.168;2.3.1.-;1.2.4.4;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0016301 kinase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045252 oxoglutarate dehydrogenase complex",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0008610 lipid biosynthetic process;GO:0010906 regulation of glucose metabolic process;GO:0009083 branched-chain amino acid catabolic process;GO:0006574 L-valine catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "O14874-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96IK1-1",
        "uniprot_id": "BOD1_HUMAN",
        "mass": 19196.0,
        "length": 185,
        "protein_name": "Biorientation of chromosomes in cell division protein 1",
        "gene_name": "BOD1",
        "organism": "Human",
        "refseq_name": "biorientation of chromosomes in cell division protein 1 isoform b",
        "refseq_ac": "NP_001153123",
        "gene_names_uniprotkb": "BOD1; FAM44B",
        "gene_names_refseq": "BOD1; FAM44B",
        "protein_names_uniprotkb": "Biorientation of chromosomes in cell division protein 1; Biorientation defective protein 1; Protein FAM44B",
        "protein_names_refseq": "biorientation defective 1; biorientation of chromosomes in cell division protein 1 isoform b; biorientation of chromosomes in cell division protein 1; family with sequence similarity 44, member B",
        "tax_id": 9606,
        "disease": "intellectual disability (Disease Ontology:DOID:1059)",
        "pathway": " (hsa:91272);  (R-HSA-9772755)",
        "pathway_count": 2,
        "publication_count": 79,
        "publication_id_list": "11237011;12393701;12482972;12670868;14636557;14992727;15199122;16227571;16239140;16829959;16878130;16892064;17355966;17500065;17612494;17671196;17925232;17938248;17998332;18598942;18829457;18829459;18838386;18838538;19103755;19124460;19187761;19556245;20018852;20575550;20716525;20961854;21106533;21124902;21131905;21135039;21220120;22266653;22327296;22652693;22665483;23508102;23995757;24157919;24244196;24368734;24680668;25561738;25593305;26324722;26886794;27563068;27698142;27760318;28182322;28218747;28398509;29138278;29142109;29437277;29557506;29897600;29937342;31400120;31485071;31544921;31844290;32157095;32578875;33657400;34012049;34145485;34171305;34933446;35033534;35190547;35439434;36241641;38253038",
        "class_list": "",
        "function": "A homozygous stop gain mutation in BOD1 gene in a Lebanese patient with syndromic intellectual disability., [RefSeq, PubMed]; Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. GeneRIF: siRNA depeletion of Fam44B (named Bod1 - Biorientation Defective 1 in this publication) resulted in persistent chromosome congression defects in metaphase., [RefSeq, PubMed]; Bod1 regulates protein phosphatase 2A at mitotic kinetochores., [RefSeq, PubMed]; MiR-142-3p ameliorates high glucose-induced renal tubular epithelial cell injury by targeting BOD1., [RefSeq, PubMed]; Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DXH8;Q9BTW1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0051721 protein phosphatase 2A binding;GO:0004864 protein phosphatase inhibitor activity",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005876 spindle microtubule;GO:0000940 outer kinetochore",
        "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0051301 cell division;GO:0007080 mitotic metaphase chromosome alignment;GO:0071962 mitotic sister chromatid cohesion, centromeric;GO:1990758 mitotic sister chromatid biorientation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "Q96IK1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H1Z8-1",
        "uniprot_id": "AUGN_HUMAN",
        "mass": 17183.0,
        "length": 148,
        "protein_name": "Augurin",
        "gene_name": "ECRG4",
        "organism": "Human",
        "refseq_name": "augurin precursor",
        "refseq_ac": "NP_115787",
        "gene_names_uniprotkb": "ECRG4; C2orf40; PRO1508",
        "gene_names_refseq": "C2orf40; ECRG4",
        "protein_names_uniprotkb": "Augurin; ECRG4; Esophageal cancer-related gene 4 protein",
        "protein_names_refseq": "augurin precursor; augurin; esophageal cancer related gene 4 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84417)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;12800218;12975309;17786363;19521989;21349154;33417325;34551201;35676661",
        "class_list": "",
        "function": "Brain endothelial cells-derived extracellular vesicles overexpressing ECRG4 inhibit glioma proliferation through suppressing inflammation and angiogenesis., [RefSeq, PubMed]; C2orf40 inhibits metastasis and regulates chemo-resistance and radio-resistance of nasopharyngeal carcinoma cells by influencing cell cycle and activating the PI3K/AKT/mTOR signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Inactivation of ECRG 4 gene by hypermethylation is a frequent molecular event in esophageal squamous cell carcinoma and may be involved in the carcinogenesis of this cancer., [RefSeq, PubMed]; MicroRNA-196b promotes gastric cancer progression by targeting ECRG4., [RefSeq, PubMed]; Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (By similarity)., [UniProtKB, UniProtKB]; Significantly lower expression of esophageal cancer-related gene 4 is associated with esophageal squamous cell carcinoma, [RefSeq, PubMed]; The restoration of ECRG4 expression in ESCC cells inhibited cell proliferation, colony formation, cell cycle progression and tumor growth in vivo. ECRG4 is a novel candidate tumor suppressor gene in ESCC., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DVK2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016324 apical plasma membrane;GO:0005576 extracellular region",
        "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0007417 central nervous system development;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0090398 cellular senescence;GO:0070314 G1 to G0 transition",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q9H1Z8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BQI9-1",
        "uniprot_id": "NRIP2_HUMAN",
        "mass": 31331.0,
        "length": 281,
        "protein_name": "Nuclear receptor-interacting protein 2",
        "gene_name": "NRIP2",
        "organism": "Human",
        "refseq_name": "nuclear receptor-interacting protein 2",
        "refseq_ac": "NP_113662",
        "gene_names_uniprotkb": "NRIP2",
        "gene_names_refseq": "NIX1; NRIP2",
        "protein_names_uniprotkb": "Nuclear receptor-interacting protein 2",
        "protein_names_refseq": "nuclear receptor-interacting protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83714)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11230166;11237011;17075290;28137278;37217939;37938771",
        "class_list": "",
        "function": "Down-regulates transcriptional activation by nuclear receptors such as NR1F2., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Results show that NRIP2 was significantly up-regulated in Colorectal cancer initiating cells (CCICs) from both cell lines and primary colorectal cancer tissues, and identified it as a novel molecule acting in Wnt pathway. The interaction between NRIP2 and RORbeta activates downstream target HBP1 and is probably involved in CCIC self-renewal. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RRE3;B4DV61",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q9BQI9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14929-1",
        "uniprot_id": "HAT1_HUMAN",
        "mass": 49541.0,
        "length": 419,
        "protein_name": "Histone acetyltransferase type B catalytic subunit",
        "gene_name": "HAT1",
        "organism": "Human",
        "refseq_name": "histone acetyltransferase type B catalytic subunit",
        "refseq_ac": "NP_003633",
        "gene_names_uniprotkb": "HAT1; KAT1",
        "gene_names_refseq": "HAT1; KAT1",
        "protein_names_uniprotkb": "Histone acetyltransferase type B catalytic subunit; 2.3.1.-; 2.3.1.48; Histone acetyltransferase 1; Histone methacryltransferase HAT1",
        "protein_names_refseq": "histone acetyltransferase type B catalytic subunit; histone methacryltransferase HAT1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8520);  (R-HSA-3214847)",
        "pathway_count": 2,
        "publication_count": 76,
        "publication_id_list": "10786633;10821277;11237011;11585814;12841681;15313887;16387653;16959974;17322306;18381289;18623064;18669648;18767875;19187765;20018852;20068231;20148353;20953179;22223895;22615379;23186163;23301498;23481700;23653357;25418920;25645385;25892735;26929215;27600516;27869121;27920218;28063628;28143904;28218747;28228285;28510447;28514659;28649982;28832583;28834231;28855257;29242379;29393594;29508533;29632046;29632711;29769354;29789417;30779550;30833945;31092671;31278053;31530632;31695772;31812350;31848261;31937595;32081014;32161166;32387766;34019948;34725712;34931806;34961760;35138101;36284347;37048148;37107673;37794134;37907924;37938771;39894887;40914422;9427644;9558366;9880483",
        "class_list": "",
        "function": "(Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell., [UniProtKB, PubMed]; Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging. Publication Status: Online-Only, [RefSeq, PubMed]; HAT1: Landscape of Biological Function and Role in Cancer. Review article Publication Status: Online-Only, [RefSeq, PubMed]; HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis and metastasis in lung adenocarcinoma., [RefSeq, PubMed]; Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:20953179, PubMed:23653357, PubMed:31278053, PubMed:32081014). Coordinates histone production and acetylation via H4 promoter binding (PubMed:31278053). Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) (PubMed:11585814, PubMed:22615379). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression (PubMed:31278053). Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23653357). In addition, acetylates other substrates such as chromatin-related proteins (PubMed:32081014). Also acetylates RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (PubMed:31812350). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-methylpropenoyl-CoA (methacryl-CoA), and is able to mediate histone methacrylation (PubMed:34961760)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]., [RefSeq]; Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease. Review article Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q49A44;Q53QF0;Q53SU4;Q6P594;Q8WWB9",
        "ec_number_list": "2.3.1.48;2.3.1.-;2.7.11.1;2.3.1.57;2.3.1.259;2.3.1.80",
        "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0042393 histone binding;GO:0004402 histone acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0140218 histone methacryltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016363 nuclear matrix",
        "go_biological_process": "GO:0006475 internal protein amino acid acetylation;GO:0031509 subtelomeric heterochromatin formation;GO:0006334 nucleosome assembly;GO:0051276 chromosome organization;GO:0006325 chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "O14929-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H2V7-1",
        "uniprot_id": "SPNS1_HUMAN",
        "mass": 56630.0,
        "length": 528,
        "protein_name": "Protein spinster homolog 1",
        "gene_name": "SPNS1",
        "organism": "Human",
        "refseq_name": "protein spinster homolog 1 isoform 1",
        "refseq_ac": "NP_001135920",
        "gene_names_uniprotkb": "SPNS1; PP20300; SPIN1",
        "gene_names_refseq": "HSpin1; LAT; PP2030; SLC62A1; SLC63A1; SPIN1; SPINL; SPNS1; nrs",
        "protein_names_uniprotkb": "Protein spinster homolog 1; HSpin1; SPNS1; Spinster-like protein 1",
        "protein_names_refseq": "SPNS sphingolipid transporter 1 (putative); protein spinster homolog 1 isoform 1; protein spinster homolog 1; solute carrier family 63 member 1; sphingolipid transporter 1 (putative); spinster-like protein 1",
        "tax_id": 9606,
        "disease": "neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); sphingolipidosis (Disease Ontology:DOID:1927)",
        "pathway": " (hsa:83985)",
        "pathway_count": 1,
        "publication_count": 43,
        "publication_id_list": "11237011;11340170;12408844;12815463;15498874;18669648;18767875;22942098;23186163;25505266;25576301;26992070;28218747;28510447;28904123;29162837;29393594;29437277;29493099;29547122;29557506;29632711;30410026;31222486;31844290;32157095;32350084;32387766;32897882;32938616;33912179;33968037;34171305;34357683;35051231;35154160;35251023;35580925;36010968;36161949;36215666;36284347;37075117",
        "class_list": "",
        "function": "A single nucleotide polymorphism located within the spns1 gene is associated with plasma triglyceride levels., [RefSeq, PubMed]; Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol (PubMed:36161949, PubMed:37075117). Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids (PubMed:36161949, PubMed:37075117). Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), can also transport lysophosphatidylglycerol (LPG), but not other anionic lysophospholipids, sphingosine, nor sphingomyelin (PubMed:36161949). Transports lysophospholipids with saturated, monounsaturated, and polyunsaturated fatty acids, such as 1-hexadecanoyl-sn-glycero-3-phosphocholine, 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine, respectively (PubMed:36161949, PubMed:37075117). Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine (PubMed:36161949). Lysosomal LPC could function as intracellular signaling messenger (PubMed:37075117). Essential player in lysosomal homeostasis (PubMed:36161949). Crucial for cell survival under conditions of nutrient limitation (PubMed:37075117). May be involved in necrotic or autophagic cell death (PubMed:12815463)., [UniProtKB, PubMed, PubMed, PubMed]; SPNS1-dependent L-leucine export across the lysosomal membrane is a key step for triggering autophagy, and that this mechanism is impaired in Niemann-Pick type C disease-1. Publication Status: Online-Only, [RefSeq, PubMed]; Spindlin 1 (SPIN1) sequesters ribosomal protein uL18 in the nucleolus, preventing it from interacting with c-mdm2 Proto-oncogene protein (MDM2), and alleviating uL18-mediated inhibition of MDM2 ubiquitin ligase activity toward p53 tumor suppressor protein (p53). Publication Status: Online-Only, [RefSeq, PubMed]; Spinster protein interferes with programmed cell death in Drosophila melanogaster and has orthologs in nematode, mouse, and human., [RefSeq, PubMed]; Spns1 is a lysosomal proton-dependent lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE) transporter mediating phospholipid salvage pathway, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MDM9;Q6P182;Q71RB5;Q7L541;Q86VU7;Q8N953;Q8TCS5;Q9BRN5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0051978 lysophospholipid:sodium symporter activity;GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0051977 lysophospholipid transport;GO:0033700 phospholipid efflux;GO:0006869 lipid transport",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "Q9H2V7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15427-1",
        "uniprot_id": "MOT4_HUMAN",
        "mass": 49469.0,
        "length": 465,
        "protein_name": "Monocarboxylate transporter 4",
        "gene_name": "SLC16A3",
        "organism": "Human",
        "refseq_name": "monocarboxylate transporter 4",
        "refseq_ac": "NP_001035887",
        "gene_names_uniprotkb": "SLC16A3; MCT3; MCT4",
        "gene_names_refseq": "MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4; SLC16A3",
        "protein_names_uniprotkb": "Monocarboxylate transporter 4; MCT 4; Solute carrier family 16 member 3",
        "protein_names_refseq": "monocarboxylate transporter 3; monocarboxylate transporter 4; solute carrier family 16 (monocarboxylate transporter), member 3; solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (monocarboxylic acid transporter 4)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9123);  (R-HSA-210991);  (R-HSA-433692)",
        "pathway_count": 3,
        "publication_count": 113,
        "publication_id_list": "10493836;10590411;10880960;10921872;11101640;11237011;11719518;11943775;12558975;12657613;13929721;14707126;15505343;15901826;15911216;15917240;15946952;16260747;16452478;16964243;17081983;17701893;17996943;18578522;18582575;18669648;18691976;18767875;19651622;20068231;21199217;23186163;23481700;23935841;24265240;24714562;24715725;25576301;25802875;26154972;26992070;27846572;27920218;28228285;28514659;28832583;28834231;28904123;29093164;29242379;29393594;29493099;29557506;29786170;30315122;30410026;30429286;30444036;30484775;30779550;30833945;31092671;31154438;31217245;31530632;31719150;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32897882;32938616;32983136;33043033;33123756;33141586;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34171305;34357683;34433824;34509645;34932366;35051231;35083852;35254053;35318648;35580925;36010968;36104287;36215666;36241641;36284347;37938771;38151007;38522774;38665916;40596516;8124722;9360995;9425115;9786900",
        "class_list": "",
        "function": "Bone Morphogenetic Protein-4 Promotes Phenotypic Modulation via SMAD-4/MCT-4 Axis in Vascular Smooth Muscle Cells., [RefSeq, PubMed]; Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line., [RefSeq, PubMed]; Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]., [RefSeq]; Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (PubMed:11101640, PubMed:23935841, PubMed:31719150). Plays a predominant role in L-lactate efflux from highly glycolytic cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Targeting tumor-intrinsic SLC16A3 to enhance anti-PD-1 efficacy via tumor immune microenvironment reprogramming., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KXG8;Q2M1P8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0050833 pyruvate transmembrane transporter activity;GO:0015650 lactate:proton symporter activity;GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane",
        "go_biological_process": "GO:0035873 lactate transmembrane transport;GO:0015718 monocarboxylic acid transport;GO:1901475 pyruvate transmembrane transport;GO:0035879 plasma membrane lactate transport;GO:0042867 pyruvate catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "O15427-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P33240-1",
        "uniprot_id": "CSTF2_HUMAN",
        "mass": 60959.0,
        "length": 577,
        "protein_name": "Cleavage stimulation factor subunit 2",
        "gene_name": "CSTF2",
        "organism": "Human",
        "refseq_name": "cleavage stimulation factor subunit 2 isoform 3",
        "refseq_ac": "NP_001293138",
        "gene_names_uniprotkb": "CSTF2",
        "gene_names_refseq": "CSTF2; CSTF64; CstF-64; XLID113",
        "protein_names_uniprotkb": "Cleavage stimulation factor subunit 2; CF-1 64 kDa subunit; CSTF 64 kDa subunit; Cleavage stimulation factor 64 kDa subunit; CstF-64",
        "protein_names_refseq": "CF-1 64 kDa subunit; CSTF 64 kDa subunit; cleavage stimulation factor 64 kDa subunit; cleavage stimulation factor subunit 2 isoform 3; cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa; cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kD",
        "tax_id": 9606,
        "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); intellectual developmental disorder, X-linked 113 (MONDO:MONDO:0958200)",
        "pathway": " (hsa:1478);  (R-HSA-6784531);  (R-HSA-72187);  (R-HSA-73856);  (R-HSA-77595);  (R-HSA-9770562);  (R-HSA-9918481)",
        "pathway_count": 7,
        "publication_count": 170,
        "publication_id_list": "10444065;10669729;11060040;11237011;11389848;11455963;11598190;11727826;11747608;11871657;11979277;12138183;12526808;12711671;12729736;12773396;12871933;14519844;14707147;14749727;14762106;15037765;15084397;15109492;15317868;15565158;15998806;16361254;16710424;17081983;17116658;17128255;17190602;17204286;17224653;1741396;17525332;17984224;18226598;18288197;18411249;18452278;18669648;18688255;18809514;18957205;18984158;19217410;19690332;19836239;20068231;20573985;20695905;20844015;21102410;21295486;21311021;21450806;21559454;21593607;21911577;21947206;22207203;22813749;22928037;22944664;22967762;23186163;23222130;23299939;23301498;23874216;24076191;24129315;24149845;24244187;24366607;2470644;24715725;24870230;25301780;25301781;25640237;25662211;25755297;25810538;25836925;25849199;26092250;26154972;26992070;27108190;27600516;27846572;27862975;28063628;28096519;28510447;28832583;28911096;29186539;29242379;29274231;29393594;29485866;29493099;29508533;29557506;29632046;29632711;29786170;29789417;29902443;30139799;30192525;30257008;30599162;30779550;30833945;31154438;31217245;31222486;31530632;31611695;31844290;31848261;31998317;32119511;32157095;32488085;32502341;32816001;32938616;32983136;33141586;33177556;33214551;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34607841;35051231;35154160;35177536;35215846;35412944;35580925;36113752;36241641;37816727;37938771;38253038;40596516;6930639;7759547;7828588;9199325;9512417;9659921;9660920;9736695",
        "class_list": "",
        "function": "Alternative polyadenylation writer CSTF2 forms a positive loop with FGF2 to promote tubular epithelial-mesenchymal transition and renal fibrosis., [RefSeq, PubMed]; CSTF2 mediated mRNA N[6]-methyladenosine modification drives pancreatic ductal adenocarcinoma m[6]A subtypes. Publication Status: Online-Only, [RefSeq, PubMed]; Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3'-kinase/protein kinase B/mammalian target of rapamycin pathway., [RefSeq, PubMed]; CstF64-Induced Shortening of the BID 3'UTR Promotes Esophageal Squamous Cell Carcinoma Progression by Disrupting ceRNA Cross-talk with ZFP36L2., [RefSeq, PubMed]; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs., [UniProtKB, PubMed, PubMed]; This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5H951;Q6LA74;Q8N502",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex;GO:0071920 cleavage body",
        "go_biological_process": "GO:1990090 cellular response to nerve growth factor stimulus;GO:0031124 mRNA 3'-end processing;GO:0071045 nuclear histone mRNA catabolic process;GO:0031440 regulation of mRNA 3'-end processing",
        "synthesized_glycan_count": 0,
        "hit_score": 17.5,
        "record_id": "P33240-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NFC6-1",
        "uniprot_id": "BD1L1_HUMAN",
        "mass": 330466.0,
        "length": 3051,
        "protein_name": "Biorientation of chromosomes in cell division protein 1-like 1",
        "gene_name": "BOD1L1",
        "organism": "Human",
        "refseq_name": "biorientation of chromosomes in cell division protein 1-like 1",
        "refseq_ac": "NP_683692",
        "gene_names_uniprotkb": "BOD1L1; BOD1L; FAM44A; KIAA1327",
        "gene_names_refseq": "BOD1L1; BOD1L; FAM44A",
        "protein_names_uniprotkb": "Biorientation of chromosomes in cell division protein 1-like 1",
        "protein_names_refseq": "biorientation of chromosomes in cell division 1-like; biorientation of chromosomes in cell division protein 1-like 1; family with sequence similarity 44, member A",
        "tax_id": 9606,
        "disease": "intellectual disability (Disease Ontology:DOID:1059)",
        "pathway": " (hsa:259282);  (R-HSA-9772755)",
        "pathway_count": 2,
        "publication_count": 160,
        "publication_id_list": "11237011;12393701;12482972;12670868;14636557;14992727;15199122;16227571;16239140;16829959;16878130;16892064;16959974;16964243;17081983;17322306;17355966;17370265;17500065;17525332;17612494;17671196;17925232;17998332;18452278;18598942;18669648;18767875;18829457;18829459;18838386;18838538;19103755;19124460;19187761;19413330;19415658;19556245;19608861;19651622;19664994;19664995;19690332;20018852;20068231;20575550;20716525;20961854;21106533;21124902;21131905;21135039;21220120;21406692;21740066;22266653;22327296;22652693;22665483;23186163;23301498;23481700;23508102;23995757;24244196;24275569;24366607;24368734;24680668;24715725;25561738;25576301;25593305;25645385;25892735;26154972;26166705;26324722;26375851;26758079;26886794;26889944;27563068;27600516;27698142;27760318;27846572;27862975;27920218;28063628;28182322;28218747;28228285;28398509;28411811;28446606;28649982;28832583;28904123;29138278;29242379;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29897600;29937342;30059200;30379171;30429286;30620550;31217245;31400120;31485071;31544921;31844290;32157095;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32938750;32983136;33141586;33298915;33592498;33657400;33717175;33912179;33936100;33968037;33981976;34012049;34087483;34171305;34185709;34509645;34933446;35033534;35051231;35190547;35254053;35318648;35439434;35494241;35580925;36010968;36215666;36241641;36581221;37938771;38989615;40307207;40596516",
        "class_list": "",
        "function": "BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A., [RefSeq, PubMed]; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705)., [UniProtKB, PubMed, PubMed]; Protection or resection: BOD1L as a novel replication fork protection factor. Review article Erratum:[doi: 10.1016/j.molcel.2015.06.007], [RefSeq, PubMed]; Results show that BOD1L protects against severe genome instability caused by replication stress; it maintains fork stability by stabilizing RAD51 nucleofilaments., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 48,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 97,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6P0M8;Q96AL1;Q9H6G0;Q9NTD6;Q9P2L9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0048188 Set1C/COMPASS complex",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0031297 replication fork processing",
        "synthesized_glycan_count": 0,
        "hit_score": 17.0,
        "record_id": "Q8NFC6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6NVV7-1",
        "uniprot_id": "CDPF1_HUMAN",
        "mass": 13877.0,
        "length": 123,
        "protein_name": "Cysteine-rich DPF motif domain-containing protein 1",
        "gene_name": "CDPF1",
        "organism": "Human",
        "refseq_name": "cysteine-rich DPF motif domain-containing protein 1",
        "refseq_ac": "NP_997210",
        "gene_names_uniprotkb": "CDPF1; C22orf40",
        "gene_names_refseq": "C22orf40; CDKN1A; CDPF1",
        "protein_names_uniprotkb": "Cysteine-rich DPF motif domain-containing protein 1",
        "protein_names_refseq": "UPF0595 protein C22orf40; cysteine-rich DPF motif domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:150383)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;18477386;31844290;33298915",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NCA1;A9IU12;A9IU16;Q3ZCR8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q6NVV7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9GZZ1-1",
        "uniprot_id": "NAA50_HUMAN",
        "mass": 19398.0,
        "length": 169,
        "protein_name": "N-alpha-acetyltransferase 50",
        "gene_name": "NAA50",
        "organism": "Human",
        "refseq_name": "N-alpha-acetyltransferase 50 isoform 1",
        "refseq_ac": "NP_079422",
        "gene_names_uniprotkb": "NAA50; MAK3; NAT13; NAT5",
        "gene_names_refseq": "MAK3; NAA50; NAT13P; NAT13; NAT5P; NAT5; SAN; hNaa50p",
        "protein_names_uniprotkb": "N-alpha-acetyltransferase 50; 2.3.1.-; 2.3.1.258; N-acetyltransferase 13; N-acetyltransferase 5; N-acetyltransferase san homolog; N-epsilon-acetyltransferase 50; NatE catalytic subunit; hNAT5; hNaa50p; hSAN",
        "protein_names_refseq": "N-acetyltransferase 13 (GCN5-related); N-acetyltransferase 5; N-acetyltransferase san homolog; N-alpha-acetyltransferase 50 isoform 1; N-epsilon-acetyltransferase 50; natE catalytic subunit",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80218)",
        "pathway_count": 1,
        "publication_count": 81,
        "publication_id_list": "11237011;15592455;16507339;17502424;18669648;19398576;19608861;19660095;19744929;20068231;20112406;20305658;21900231;22311970;23186163;24366607;24715725;25418920;25576301;25732826;26154972;26758079;26811146;26992070;27422821;27484799;27846572;27920218;28063628;28218747;28514659;28832583;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29754825;29930882;30315122;30484775;30524438;30779550;30833945;31154438;31222486;31530632;31844290;32042062;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33592498;33691108;33912179;33968037;33981976;34087483;34171305;34229054;34357683;34932366;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37938771;38665916",
        "class_list": "",
        "function": "Because Naa10 is reported to acetylate all amino termini that are devoid of methionine and Naa50 acetylates all other peptides that are followed by methionine, [RefSeq, PubMed]; Data show that with MAK3 knockdown, p53 is stabilized and phosphorylated and there is a significant transcriptional activation of proapoptotic genes downstream of p53, and that localization of Arl8b is altered, suggesting that Arl8b is a Mak3 substrate., [RefSeq, PubMed]; May be specifically required for the maintenance of centromeric cohesion in mitosis., [RefSeq, PubMed]; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (PubMed:19744929, PubMed:21900231, PubMed:22311970, PubMed:27484799). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (PubMed:27484799). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (PubMed:19744929). Autoacetylates in vivo (PubMed:19744929). The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (PubMed:19744929). Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity (PubMed:16507339, PubMed:27484799, PubMed:29754825, PubMed:32042062). Does not influence the acetyltransferase activity of NAA10 (PubMed:16507339, PubMed:27484799). However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex) (PubMed:32042062). The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (PubMed:16507339, PubMed:27484799). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 (PubMed:17502424, PubMed:27422821)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The first description of the human homologue of Nat5p/San, hNAT5, the third component of the human NatA N-alpha-acetyltransferase complex, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 19,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DN74;Q68DQ1",
        "ec_number_list": "2.3.1.256;2.3.1.258;2.3.1.-",
        "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity;GO:0016746 acyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0043687 post-translational protein modification;GO:0071962 mitotic sister chromatid cohesion, centromeric;GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0007064 mitotic sister chromatid cohesion;GO:0006474 N-terminal protein amino acid acetylation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "Q9GZZ1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P04920-1",
        "uniprot_id": "B3A2_HUMAN",
        "mass": 137009.0,
        "length": 1241,
        "protein_name": "Anion exchange protein 2",
        "gene_name": "SLC4A2",
        "organism": "Human",
        "refseq_name": "anion exchange protein 2 isoform 1",
        "refseq_ac": "NP_001186621",
        "gene_names_uniprotkb": "SLC4A2; AE2; EPB3L1; HKB3; MPB3L",
        "gene_names_refseq": "AE2; BND3L; EPB3L1; HKB3; NBND3; OPTB9; SLC4A2",
        "protein_names_uniprotkb": "Anion exchange protein 2; AE 2; Anion exchanger 2; BND3L; Non-erythroid band 3-like protein; Solute carrier family 4 member 2",
        "protein_names_refseq": "anion exchange protein 2 isoform 1; anion exchange protein 2; anion exchanger 2 type a; anion exchanger 2 type b1; anion exchanger 2 type b2; erythrocyte membrane protein band 3-like 1; non-erythroid band 3-like protein; solute carrier family 4 (anion exchanger), member 2",
        "tax_id": 9606,
        "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); prediabetes syndrome (Disease Ontology:DOID:11716); osteopetrosis (Disease Ontology:DOID:13533); anemia (Disease Ontology:DOID:2355); osteopetrosis, autosomal recessive 9 (MONDO:MONDO:0957262)",
        "pathway": " (hsa:6522);  (R-HSA-425381)",
        "pathway_count": 2,
        "publication_count": 76,
        "publication_id_list": "10.1101/2023.09.13.557529;10347222;10362779;10545938;10623603;10978526;11237011;11305939;11788353;15184086;1562608;17081983;18319254;18452278;18669648;19413330;19690332;20068231;21406692;23186163;24129315;24190977;24472682;25502872;25505266;25576301;2594752;26992070;28467828;3015590;30484775;30626607;31154438;31844290;31848261;32157095;32161166;32265295;32350084;32357974;32488085;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33633747;33912179;33936100;33968037;33981976;34078123;34211107;34279699;34357683;34668226;34944008;35051231;35251023;35318648;35580925;36215666;36241641;36343920;37217939;37270778;39894887;7506871;7530501;7923606;8206915;9235899;9312167;9651366",
        "class_list": "",
        "function": "Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2., [RefSeq, PubMed]; Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid-Base Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel Mechanism for a Co-Occurring Polyautoimmune Scenario. Publication Status: Online-Only, [RefSeq, PubMed]; SLC4A2 anion exchanger promotes tumour cell malignancy via enhancing net acid efflux across golgi membranes., [RefSeq, PubMed]; SLC4A2, another gene involved in acid-base balancing machinery of osteoclasts, causes osteopetrosis. Review article, [RefSeq, PubMed]; Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary biliary cirrhosis (PBC) in human patients, while differential expression of this gene may be associated with malignant hepatocellular carcinoma, colon and gastric cancers. [provided by RefSeq, Nov 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 17,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 39,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 5,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6T0;B4DIT0;D3DX05;F8W682;Q45EY5;Q969L3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0022857 transmembrane transporter activity;GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0140900 chloride:bicarbonate antiporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0045124 regulation of bone resorption;GO:0007283 spermatogenesis;GO:0032956 regulation of actin cytoskeleton organization;GO:0055085 transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "P04920-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P23560-1",
        "uniprot_id": "BDNF_HUMAN",
        "mass": 27818.0,
        "length": 247,
        "protein_name": "Neurotrophic factor BDNF precursor form",
        "gene_name": "BDNF",
        "organism": "Human",
        "refseq_name": "neurotrophic factor BDNF precursor form isoform a preproprotein",
        "refseq_ac": "NP_001137277",
        "gene_names_uniprotkb": "BDNF",
        "gene_names_refseq": "ANON2; BDNF; BULN2",
        "protein_names_uniprotkb": "Neurotrophic factor BDNF precursor form; Abrineurin; Brain-derived neurotrophic factor; proBDNF",
        "protein_names_refseq": "abrineurin; neurotrophic factor BDNF precursor form isoform a preproprotein; neurotrophic factor BDNF precursor form; neurotrophin; proBDNF",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); congenital central hypoventilation syndrome (Disease Ontology:DOID:0060731); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); keratoconus (Disease Ontology:DOID:10126); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); amnestic disorder (Disease Ontology:DOID:10914); obsessive-compulsive disorder (Disease Ontology:DOID:10933); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); sciatic neuropathy (Disease Ontology:DOID:11446); trigeminal neuralgia (Disease Ontology:DOID:12098); acoustic neuroma (Disease Ontology:DOID:12689); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); color blindness (Disease Ontology:DOID:13399); pulmonary sarcoidosis (Disease Ontology:DOID:13406); low tension glaucoma (Disease Ontology:DOID:13544); premature ejaculation (Disease Ontology:DOID:13709); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); major depressive disorder (Disease Ontology:DOID:1470); urticaria (Disease Ontology:DOID:1555); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); cystitis (Disease Ontology:DOID:1679); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); anxiety disorder (Disease Ontology:DOID:2030); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); atopic dermatitis (Disease Ontology:DOID:3310); mood disorder (Disease Ontology:DOID:3324); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); rhinitis (Disease Ontology:DOID:4483); borna disease (Disease Ontology:DOID:5154); intestinal disease (Disease Ontology:DOID:5295); acute stress disorder (Disease Ontology:DOID:6088); amphetamine abuse (Disease Ontology:DOID:670); retinal degeneration (Disease Ontology:DOID:8466); vascular dementia (Disease Ontology:DOID:8725); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypertensive encephalopathy (Disease Ontology:DOID:9427); bacterial meningitis (Disease Ontology:DOID:9470); cannabis abuse (Disease Ontology:DOID:9505); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); diabetic neuropathy (Disease Ontology:DOID:9743); irritable bowel syndrome (Disease Ontology:DOID:9778); alopecia (Disease Ontology:DOID:987); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)",
        "pathway": " (hsa:627);  (R-HSA-1257604);  (R-HSA-2219530);  (R-HSA-6811558);  (R-HSA-9022702);  (R-HSA-9024909);  (R-HSA-9026519);  (R-HSA-9026527);  (R-HSA-9028335);  (R-HSA-9028731);  (R-HSA-9032500);  (R-HSA-9032759);  (R-HSA-9032845);  (R-HSA-9768919)",
        "pathway_count": 14,
        "publication_count": 98,
        "publication_id_list": "10.1101/2023.09.13.557529;10191262;10196222;10391209;10579907;10631974;11147812;11152678;11214319;11237011;11803464;11840487;12167717;12553913;12767043;12836135;12888803;1325671;1339267;14566559;14593183;14593184;14701734;15115760;15666411;15718470;15834429;16339315;16456541;16647110;17200115;17626883;17629449;17994015;18079394;18317450;18594509;18606717;18753648;18754654;18755892;18829560;1889806;18925875;19185485;19411071;19467646;19576174;19644473;19805105;19914329;19962665;20231295;2025430;20338997;20368433;20522708;20713702;20977903;21188471;21317208;21368041;21368164;21478295;21668414;21827948;21976531;21984976;22120714;22188813;2236018;22588880;22652301;22802530;23712400;24291638;24465693;24470253;24908487;24913346;27472814;28397838;29402794;29557506;29909994;33592498;38982490;38988190;39334009;39392027;7637810;7703225;7744773;8527932;8645157;8657148;9736715;9895304",
        "class_list": "",
        "function": "APOExBDNF Interaction and Poorer Cognitive Outcomes Among Veterans With Mild Traumatic Brain Injury: An Exploratory Study., [RefSeq, PubMed]; Assessment of brain-derived neurotrophic factor and irisin concentration in children with chronic kidney disease: a pilot study. Publication Status: Online-Only, [RefSeq, PubMed]; Association between the Val66Met (rs6265) polymorphism of the brain-derived neurotrophic factor (BDNF) gene, BDNF protein level in the blood and the risk of developing early-onset Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Depletion of placental brain-derived neurotrophic factor (BDNF) is attributed to premature ovarian insufficiency (POI) in mice offspring. Publication Status: Online-Only, [RefSeq, PubMed]; Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability., [UniProtKB, PubMed, PubMed, PubMed]; Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 67,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7LA85;A7LA92;D3DQZ2;Q598Q1;Q6DN19;Q6YNR2;Q6YNR3;Q9BYY7;Q9UC24",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0048812 neuron projection morphogenesis;GO:0043524 negative regulation of neuron apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 10.1,
        "record_id": "P23560-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00198-1",
        "uniprot_id": "HRK_HUMAN",
        "mass": 9884.0,
        "length": 91,
        "protein_name": "Activator of apoptosis harakiri",
        "gene_name": "HRK",
        "organism": "Human",
        "refseq_name": "activator of apoptosis harakiri",
        "refseq_ac": "NP_003797",
        "gene_names_uniprotkb": "HRK; BID3",
        "gene_names_refseq": "DP5; HARAKIRI; HRK",
        "protein_names_uniprotkb": "Activator of apoptosis harakiri; BH3-interacting domain-containing protein 3; Neuronal death protein DP5",
        "protein_names_refseq": "BH3-interacting domain-containing protein 3; activator of apoptosis Hrk; activator of apoptosis harakiri; death protein 5; harakiri, BCL2 interacting protein (contains only BH3 domain); neuronal death protein DP5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8739)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;15031724;18008329;21731739;31135059;32620849;32900773;33174041;9130713",
        "class_list": "",
        "function": "Characterization of an alternative BAK-binding site for BH3 peptides. Publication Status: Online-Only, [RefSeq, PubMed]; HRK appears to be inactivated principally by promoter hypermethylation in prostate cancers and decreased expression may play an important role in tumor progression by modulating apoptotic cell death, [RefSeq, PubMed]; In individuals with susceptible genetic backgrounds, Coxsackie B viral infection alters the epigenome to activate the pathological pathways leading to polymyositis-dermatomyositis via mitochondrial dysfunction and HRK up-regulation., [RefSeq, PubMed]; Promotes apoptosis., [UniProtKB, PubMed, PubMed]; This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]., [RefSeq]; Upregulated lncHRK2:1 prompts nucleus pulposus cell senescence in intervertebral disc degeneration., [RefSeq, PubMed]; YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane",
        "go_biological_process": "GO:0051365 cellular response to potassium ion starvation;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0031334 positive regulation of protein-containing complex assembly;GO:0043525 positive regulation of neuron apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "O00198-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96HR8-1",
        "uniprot_id": "NAF1_HUMAN",
        "mass": 53717.0,
        "length": 494,
        "protein_name": "H/ACA ribonucleoprotein complex non-core subunit NAF1",
        "gene_name": "NAF1",
        "organism": "Human",
        "refseq_name": "H/ACA ribonucleoprotein complex non-core subunit NAF1 isoform b",
        "refseq_ac": "NP_001122403",
        "gene_names_uniprotkb": "NAF1",
        "gene_names_refseq": "NAF1; PFBMFT7",
        "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex non-core subunit NAF1; hNAF1",
        "protein_names_refseq": "H/ACA ribonucleoprotein complex non-core subunit NAF1 isoform b; h/ACA ribonucleoprotein complex non-core subunit NAF1; nuclear assembly factor 1 homolog",
        "tax_id": 9606,
        "disease": "melanoma (Disease Ontology:DOID:1909); pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 7 (MONDO:MONDO:0957261)",
        "pathway": " (hsa:92345)",
        "pathway_count": 1,
        "publication_count": 53,
        "publication_id_list": "11237011;15302935;16601202;16618814;17081983;17135485;18452278;18669648;18767875;19413330;19651622;19664994;20068231;21406692;23186163;23301498;23481700;25502872;25576301;25645385;26154972;27510903;28218747;28228285;28832583;29242379;29437277;29493099;29557506;30410026;31154438;31530632;31844290;31848261;32157095;32357974;32502341;32938616;33141586;33392160;33592498;33717175;33912179;33968037;34357683;34561969;34932366;35580925;36067202;36215666;36241641;36284347;36855016",
        "class_list": "",
        "function": "Colorectal cancer-associated SNP rs17042479 is involved in the regulation of NAF1 promoter activity. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4., [UniProtKB, PubMed]; Relationship between common telomere length-related genetic variations, telomere length, and risk of antituberculosis drug-induced hepatotoxicity in Chinese Han population: As assessed for causality using the updated Roussel Uclaf Causality Assessment Method., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DP28;E9PAZ2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0070034 telomerase RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex",
        "go_biological_process": "GO:0090671 telomerase RNA localization to Cajal body;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0042254 ribosome biogenesis;GO:1904358 positive regulation of telomere maintenance via telomere lengthening;GO:1905323 telomerase holoenzyme complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q96HR8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BVI4-1",
        "uniprot_id": "NOC4L_HUMAN",
        "mass": 58468.0,
        "length": 516,
        "protein_name": "Nucleolar complex protein 4 homolog",
        "gene_name": "NOC4L",
        "organism": "Human",
        "refseq_name": "nucleolar complex protein 4 homolog isoform 1",
        "refseq_ac": "NP_076983",
        "gene_names_uniprotkb": "NOC4L",
        "gene_names_refseq": "NET49; NOC4L; NOC4; UTP19",
        "protein_names_uniprotkb": "Nucleolar complex protein 4 homolog; NOC4 protein homolog; NOC4-like protein; Nucleolar complex-associated protein 4-like protein",
        "protein_names_refseq": "NOC4 protein homolog; NOC4-like protein; nucleolar complex protein 4 homolog isoform 1; nucleolar complex protein 4 homolog; nucleolar complex-associated protein 4-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79050);  (R-HSA-6790901);  (R-HSA-6791226)",
        "pathway_count": 3,
        "publication_count": 128,
        "publication_id_list": "10606270;11081632;11237011;11922599;11935223;11978965;12068309;12150911;12417735;12429849;15199136;16037817;16043514;16381836;16738141;16782898;17189298;17353269;17412707;17636026;18065403;18438418;19033376;19106111;19332556;19463982;19564402;19801658;20038530;20047967;20056613;20531386;20798176;20805244;20819938;21036871;21063389;21097556;22072790;22190735;22195017;22898188;22916032;23391857;23439679;23481700;23482395;2388630;24086612;24424021;24550520;24715725;25411247;25418920;25525153;25645385;25653167;25851604;25880248;25969445;26085946;26154972;26196125;26237581;26375851;26992070;27084949;27600516;27846572;27920218;28012024;28218747;28228285;28832583;28834231;29242379;29437277;29493099;29508533;29557506;29632711;29786170;30315122;30429286;30524438;30779550;31154438;31222486;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34405274;34509645;35051231;35580925;35702822;36010968;36215666;36241641;37938771;40914422;9211966;9482744;9512526",
        "class_list": "",
        "function": "Oncogenic fusion transcript analysis identified ADAP1-NOC4L, potentially associated with metastatic colorectal cancer., [RefSeq, PubMed]; The results provide the first in vivo genetic evidence that Noc4l plays important roles in early embryogenesis in mice., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N2S5;Q96I14",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031965 nuclear membrane;GO:0030692 Noc4p-Nop14p complex;GO:0032040 small-subunit processome",
        "go_biological_process": "GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042254 ribosome biogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 13.1,
        "record_id": "Q9BVI4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BQE9-1",
        "uniprot_id": "BCL7B_HUMAN",
        "mass": 22195.0,
        "length": 202,
        "protein_name": "B-cell CLL/lymphoma 7 protein family member B",
        "gene_name": "BCL7B",
        "organism": "Human",
        "refseq_name": "B-cell CLL/lymphoma 7 protein family member B isoform 2",
        "refseq_ac": "NP_001184173",
        "gene_names_uniprotkb": "BCL7B",
        "gene_names_refseq": "BCL7B; SMARCJ2",
        "protein_names_uniprotkb": "B-cell CLL/lymphoma 7 protein family member B",
        "protein_names_refseq": "B-cell CLL/lymphoma 7 protein family member B isoform 2; B-cell CLL/lymphoma 7 protein family member B; B-cell CLL/lymphoma 7B; BCL tumor suppressor 7B; BCL7B, BAF complex component",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9275);  (R-HSA-9824585);  (R-HSA-9845323);  (R-HSA-9933937);  (R-HSA-9933939);  (R-HSA-9933946);  (R-HSA-9933947);  (R-HSA-9934037)",
        "pathway_count": 8,
        "publication_count": 80,
        "publication_id_list": "10078207;10587587;11237011;11532965;11856727;11964381;12062444;12368262;1321344;1537333;1537334;15543135;15640446;15695812;15729346;15985610;16265664;16303920;17081983;17182843;17498659;17640523;17952075;18452278;18483556;18669648;18697795;18765789;18809673;18812475;19389701;19651622;19690332;19717472;20068231;21555454;22464331;22952240;23186163;23644491;23785148;24267888;25569233;26024233;26365797;26601204;26694611;27600516;27771473;27920218;28218747;28533407;28649982;29242379;29374058;29393594;30515787;30833945;31166991;32387766;32938616;33100333;33912179;34171305;34465901;34509645;35051231;35580127;37340703;38359823;40596516;7813420;8306979;8605326;8804307;8921401;9758418;9806765;9860302;9931421",
        "class_list": "",
        "function": "Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity)., [UniProtKB, PubMed, UniProtKB]; The combination of PODXL with ITGB1 and the combination of BCL7B with ITGB1 accurately predicted the postoperative outcomes of pancreatic cancer patients. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010]., [RefSeq]; We herewith propose that the BCL7B gene, located in the chromosomal region commonly deleted in Williams syndrome, could potentially have a role in this particular association., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K226;C9JWD3;D3DXF0;O43769;Q13845;Q6ZW75",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0000785 chromatin",
        "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "Q9BQE9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96SQ9-1",
        "uniprot_id": "CP2S1_HUMAN",
        "mass": 55817.0,
        "length": 504,
        "protein_name": "Cytochrome P450 2S1",
        "gene_name": "CYP2S1",
        "organism": "Human",
        "refseq_name": "cytochrome P450 2S1 precursor",
        "refseq_ac": "NP_085125",
        "gene_names_uniprotkb": "CYP2S1; PRO1906",
        "gene_names_refseq": "CYP2S1; CYPIIS1",
        "protein_names_uniprotkb": "Cytochrome P450 2S1; 1.14.14.-; 4.2.1.152; 5.3.99.5; CYPIIS1; Hydroperoxy icosatetraenoate dehydratase; Thromboxane-A synthase",
        "protein_names_refseq": "cytochrome P450 2S1 precursor; cytochrome P450 2S1; cytochrome P450, family 2, subfamily S, polypeptide 1; cytochrome P540, subfamily IIS, polypeptide 1; hydroperoxy icosatetraenoate dehydratase; thromboxane-A synthase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29785);  (R-HSA-211958);  (R-HSA-211981);  (R-HSA-211999)",
        "pathway_count": 4,
        "publication_count": 61,
        "publication_id_list": "10383923;10731522;10741631;11160876;11181079;11237011;11701230;12464245;12629583;12711469;12975309;14660610;15196988;15365656;15450424;15454734;15548719;15665333;16359177;1664256;16677611;17277313;18065749;2025243;21068195;25576301;27893789;29557506;29789417;30779550;31154438;31844290;31848261;32387766;32938616;32983136;33141586;33377261;33537174;33981976;34185709;34275895;34509645;35051231;35535391;35902379;36241641;36284347;497175;6220203;7217086;7903454;8627510;8637342;8647857;8975785;9028626;9103523;9644715;9842986;9884161",
        "class_list": "",
        "function": "A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195). In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195)., [UniProtKB, PubMed, PubMed]; CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer., [RefSeq, PubMed]; CYP2S1 rs338599 polymorphism confers reduced risk to anti-tuberculosis drug-induced liver injury and may be a novel marker for its risk prediction., [RefSeq, PubMed]; Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia., [RefSeq, PubMed]; Identify a novel regulatory cassette that mediates changes in Cyp2s1 expression, [RefSeq, PubMed]; Knockdown CYP2S1 inhibits lung cancer cells proliferation and migration., [RefSeq, PubMed]; Observational study of genotype prevalence. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BZ66",
        "ec_number_list": "1.14.14.1;4.2.1.152;1.14.13.n7;1.14.14.55;1.14.14.56;1.14.14.73;1.14.14.-;1.14.14.51;1.14.14.52;1.14.14.53;1.14.13.-;5.3.99.5;1.14.14.75;5.4.4.7;1.14.14.74;5.3.99.4;5.3.99.3",
        "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016836 hydro-lyase activity;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006690 icosanoid metabolic process;GO:0042573 retinoic acid metabolic process;GO:0006805 xenobiotic metabolic process;GO:0006693 prostaglandin metabolic process;GO:0019373 epoxygenase P450 pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q96SQ9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P1L5-1",
        "uniprot_id": "F117B_HUMAN",
        "mass": 61968.0,
        "length": 589,
        "protein_name": "Protein FAM117B",
        "gene_name": "FAM117B",
        "organism": "Human",
        "refseq_name": "protein FAM117B",
        "refseq_ac": "NP_775782",
        "gene_names_uniprotkb": "FAM117B; ALS2CR13",
        "gene_names_refseq": "ALS2CR13; FAM117B",
        "protein_names_uniprotkb": "Protein FAM117B; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein",
        "protein_names_refseq": "amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 13; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein; protein FAM117B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:150864)",
        "pathway_count": 1,
        "publication_count": 31,
        "publication_id_list": "10.1101/2023.09.13.557529;11586298;18220336;18669648;18767875;19413330;19651622;19664994;19664995;19690332;20068231;23186163;23301498;25880248;26154972;28218747;28657654;28834231;29393594;29437277;30315122;31092671;31844290;32350084;32502341;33298915;33912179;33968037;35051231;35251023;36719368",
        "class_list": "",
        "function": "FAM117B promotes gastric cancer growth and drug resistance by targeting the KEAP1/NRF2 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53QZ5;Q585T9;Q8N8W1;Q96Q34",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q6P1L5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86XJ1-1",
        "uniprot_id": "GA2L3_HUMAN",
        "mass": 75214.0,
        "length": 694,
        "protein_name": "GAS2-like protein 3",
        "gene_name": "GAS2L3",
        "organism": "Human",
        "refseq_name": "GAS2-like protein 3 isoform a",
        "refseq_ac": "NP_001290059",
        "gene_names_uniprotkb": "GAS2L3",
        "gene_names_refseq": "G2L3; GAS2L3",
        "protein_names_uniprotkb": "GAS2-like protein 3; Growth arrest-specific protein 2-like 3",
        "protein_names_refseq": "GAS2-like protein 3 isoform a; GAS2-like protein 3; growth arrest-specific protein 2-like 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283431)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;18669648;19691289;20068231;21561867;22344256;23186163;23469016;24571573;24706950;25576301;27600516;27846572;28411811;28834231;28904123;29242379;29485866;29557506;31844290;32157095;32938616;32983136;33968037;34087483;35051231;35580925;38253038",
        "class_list": "",
        "function": "Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network., [UniProtKB, PubMed]; GAS2L3, a target gene of the DREAM complex, is required for cytokinesis and genomic stability., [RefSeq, PubMed]; Show that the GAR domain of GAS2L3 is required for localization of GAS2L3 to the constriction zone, [RefSeq, PubMed]; Show that the Gas2l3 protein is targeted for ubiquitin-mediated proteolysis by the APC/C(Cdh1) complex, but not by the APC/C(Cdc20) complex, and is phosphorylated by Cdk1 in mitosis, [RefSeq, PubMed]; Tubulin acetylation drives GAS2-like 3 localization to MTs and may provide functional insights into the role of GAS2-like 3., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCN2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0051015 actin filament binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015629 actin cytoskeleton;GO:0015630 microtubule cytoskeleton;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0000226 microtubule cytoskeleton organization;GO:0051764 actin crosslink formation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q86XJ1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P23769-1",
        "uniprot_id": "GATA2_HUMAN",
        "mass": 50500.0,
        "length": 480,
        "protein_name": "Endothelial transcription factor GATA-2",
        "gene_name": "GATA2",
        "organism": "Human",
        "refseq_name": "endothelial transcription factor GATA-2 isoform 1",
        "refseq_ac": "NP_001139133",
        "gene_names_uniprotkb": "GATA2",
        "gene_names_refseq": "DCML; GATA2; IMD21; MONOMAC; NFE1B",
        "protein_names_uniprotkb": "Endothelial transcription factor GATA-2; GATA-binding protein 2",
        "protein_names_refseq": "endothelial transcription factor GATA-2 isoform 1; endothelial transcription factor GATA-2",
        "tax_id": 9606,
        "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); immunodeficiency 21 (Disease Ontology:DOID:0111947); pre-eclampsia (Disease Ontology:DOID:10591); aplastic anemia (Disease Ontology:DOID:12449); depressive disorder (Disease Ontology:DOID:1596); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myeloid leukemia (Disease Ontology:DOID:8692); acute myeloid leukemia (Disease Ontology:DOID:9119); deafness-lymphedema-leukemia syndrome (MONDO:MONDO:0013540)",
        "pathway": " (hsa:2624);  (R-HSA-8939236);  (R-HSA-9616222);  (R-HSA-983231)",
        "pathway_count": 4,
        "publication_count": 108,
        "publication_id_list": "10233885;10330422;11042108;11062261;11237011;11242053;11242107;11340171;11369759;11564866;11684017;11744692;11751636;11847229;11867521;11895428;11950885;12032298;12134158;12242300;12427746;12702500;12869508;1370462;14517214;15020713;15247287;15678106;15710388;15837948;16054028;1630448;16751774;17027967;17063141;1714909;17196961;17562868;18250304;18280240;18452278;18701449;18776924;19293402;20068231;20530532;20627800;20661648;20887958;21471526;21571218;21670465;218813;21892158;21892162;21993314;22012064;22371011;22474248;22897851;23001182;23186163;23887938;24129315;24379003;24584857;25043025;25056917;2524830;25394790;25784653;26845023;26992070;27137657;2721961;28832583;29431622;29557506;30379171;30620550;31848261;32157095;32938616;3409321;35051231;35254053;35580925;36284347;37541260;37938771;38665916;39068217;39379099;39531497;40596516;7541039;7862113;8662638;8695841;8816476;8846917;9065479;9177240;9230307;9326583;9331217;9422515;9927674",
        "class_list": "",
        "function": "GATA2 downregulation contributes to pro-inflammatory phenotype and defective phagocytosis of pulmonary macrophages in chronic obstructive pulmonary disease., [RefSeq, PubMed]; GATA2 promotes castration-resistant prostate cancer development by suppressing IFN-beta axis-mediated antitumor immunity., [RefSeq, PubMed]; The GATA-2 transcription factor interacts with the human eNOS promoter at a region which includes a putative GATA site [-230 to -226]., [RefSeq, PubMed]; This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]., [RefSeq]; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'., [UniProtKB]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 9,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DNB3;Q53YE0;Q96BH0;Q96BH8;Q9BUJ6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:0035854 eosinophil fate commitment;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0010628 positive regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "P23769-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14793-1",
        "uniprot_id": "GDF8_HUMAN",
        "mass": 42750.0,
        "length": 375,
        "protein_name": "Growth/differentiation factor 8",
        "gene_name": "MSTN",
        "organism": "Human",
        "refseq_name": "growth/differentiation factor 8 preproprotein",
        "refseq_ac": "NP_005250",
        "gene_names_uniprotkb": "MSTN; GDF8",
        "gene_names_refseq": "GDF8; MSLHP; MSTN",
        "protein_names_uniprotkb": "Growth/differentiation factor 8; GDF-8; Myostatin",
        "protein_names_refseq": "growth/differentiation factor 8 preproprotein; growth/differentiation factor 8; myostatin-b",
        "tax_id": 9606,
        "disease": "vertebral hypersegmentation and orofacial anomalies (Disease Ontology:DOID:0070418); myostatin-related muscle hypertrophy (Disease Ontology:DOID:0111072); hypothyroidism (Disease Ontology:DOID:1459); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); peripheral vascular disease (Disease Ontology:DOID:341); uremia (Disease Ontology:DOID:4676); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767)",
        "pathway": " (hsa:2660);  (R-HSA-9617828)",
        "pathway_count": 2,
        "publication_count": 25,
        "publication_id_list": "10.1101/2023.09.13.557529;11884591;11964479;12595574;15084259;15215484;15458387;17186467;17878677;18444242;23580232;23918930;24047697;25843800;27625211;28257634;32387766;35051231;35494241;38088865;38117215;38136649;38309190;9356471;9843994",
        "class_list": "",
        "function": "Acts specifically as a negative regulator of skeletal muscle growth., [UniProtKB, UniProtKB]; Myostatin and the Heart. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Relation between myostatin levels and malnutrition and muscle wasting in hemodialysis patients. Publication Status: Online-Only, [RefSeq, PubMed]; Role of irisin and myostatin on sarcopenia in malnourished patients diagnosed with GLIM criteria., [RefSeq, PubMed]; Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes., [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1C2J7;A1C2K0;Q6B0H2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0014816 skeletal muscle satellite cell differentiation;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0045471 response to ethanol;GO:0046716 muscle cell cellular homeostasis;GO:0007179 transforming growth factor beta receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "O14793-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09681-1",
        "uniprot_id": "GIP_HUMAN",
        "mass": 17108.0,
        "length": 153,
        "protein_name": "Gastric inhibitory polypeptide",
        "gene_name": "GIP",
        "organism": "Human",
        "refseq_name": "gastric inhibitory polypeptide preproprotein",
        "refseq_ac": "NP_004114",
        "gene_names_uniprotkb": "GIP",
        "gene_names_refseq": "GIP",
        "protein_names_uniprotkb": "Gastric inhibitory polypeptide; GIP; Glucose-dependent insulinotropic polypeptide; Incretin hormone",
        "protein_names_refseq": "gastric inhibitory polypeptide preproprotein; glucose-dependent insulinotropic polypeptide; incretin hormone",
        "tax_id": 9606,
        "disease": "autonomic nervous system disease (Disease Ontology:DOID:11465); polycystic ovary syndrome (Disease Ontology:DOID:11612); hypothyroidism (Disease Ontology:DOID:1459); hyperinsulinism (Disease Ontology:DOID:2018); pancreas disease (Disease Ontology:DOID:26); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:2695);  (R-HSA-400511);  (R-HSA-418555);  (R-HSA-420092)",
        "pathway_count": 4,
        "publication_count": 89,
        "publication_id_list": "10322410;10366038;10698200;11007482;11060443;11946536;12036966;12058044;12106601;12180353;12860470;1333056;13549488;14671004;1517224;15464082;15471943;15522230;15584901;15765929;15769620;15951850;16219666;16313925;16687412;16923326;17168849;1739432;18044684;18202141;18519800;18577758;18593849;19105585;19876791;19929708;20381629;21036126;2163110;2417744;24687066;2491850;2553411;2553705;26417854;2739653;2826231;2871555;2890159;29443750;29557506;29602314;30833991;3127824;31279028;31399091;31983287;32226383;32497535;32540603;32618402;32715661;33049737;35397169;35846282;36111559;36284347;36539382;36799940;3899557;6085243;6192430;6745415;7589426;7680413;7700244;7811244;7902709;8100523;8144028;8340388;8390245;8428636;8514797;8672451;9263355;9417641;9651336;9990065",
        "class_list": "",
        "function": "GIP Affects Hepatic Fat and Brown Adipose Tissue Thermogenesis but Not White Adipose Tissue Transcriptome in Type 1 Diabetes., [RefSeq, PubMed]; Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion in humans: Characteristics and regulation. Review article, [RefSeq, PubMed]; Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies., [RefSeq, PubMed]; Loss of the Incretin Effect in Type 2 Diabetes: A Systematic Review and Meta-analysis., [RefSeq, PubMed]; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion., [UniProtKB]; The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VB42;Q6NTD3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031769 glucagon receptor binding;GO:0005179 hormone activity;GO:0031767 gastric inhibitory polypeptide receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0034774 secretory granule lumen",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0042304 regulation of fatty acid biosynthetic process;GO:0050796 regulation of insulin secretion",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "P09681-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P23284-1",
        "uniprot_id": "PPIB_HUMAN",
        "mass": 23743.0,
        "length": 216,
        "protein_name": "Peptidyl-prolyl cis-trans isomerase B",
        "gene_name": "PPIB",
        "organism": "Human",
        "refseq_name": "peptidyl-prolyl cis-trans isomerase B precursor",
        "refseq_ac": "NP_000933",
        "gene_names_uniprotkb": "PPIB; CYPB",
        "gene_names_refseq": "CYP-S1; CYPB; HEL-S-39; OI9; PPIB; SCYLP",
        "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase B; 5.2.1.8; CYP-S1; Cyclophilin B; PPIase B; Rotamase B; S-cyclophilin; SCYLP",
        "protein_names_refseq": "PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory protein Li 39; peptidyl-prolyl cis-trans isomerase B precursor; peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B (cyclophilin B); rotamase B",
        "tax_id": 9606,
        "disease": "osteogenesis imperfecta type 9 (Disease Ontology:DOID:0110349)",
        "pathway": " (hsa:5479);  (R-HSA-1650814);  (R-HSA-9692916)",
        "pathway_count": 3,
        "publication_count": 168,
        "publication_id_list": "10.1101/2023.09.13.557529;10479448;10934207;11237011;12473679;12475640;12475965;12646579;1286667;12886526;1323838;14500733;14720331;15044469;15129427;15201997;15208624;1530944;1577494;16591531;17035307;17081065;1710767;17270291;17412287;17596301;17761676;18487197;19075007;19380580;19398035;19693541;19781681;2000394;20068231;20089953;20147391;20305658;2040592;20470363;20676357;20801878;21280149;21878990;21932426;21967573;22046132;22253733;22312431;22898188;23090970;23483519;24190977;24509444;24622840;24715725;24854014;24992895;25135833;2543975;25502872;25576301;25645385;25662406;25764917;25907116;26154972;26320399;26375851;26378163;26992070;27164085;27203180;27600516;27703488;27846572;27920218;28148787;28178396;28188670;28228285;28416261;28467828;28514659;28622427;28834231;28855257;28904123;29242379;29294448;29393594;29508533;29557506;29632711;29786170;29938870;30185776;30192525;30410026;30429286;30444036;30484775;30524438;31034780;31154438;31217245;31231549;31611695;31634494;3173483;31844290;32119511;32125861;32157095;32162654;32236612;32265295;32350084;32357974;32387766;32728199;32870666;32938616;32983136;33060197;33214551;33298915;33437477;33537174;33592498;33691108;33717175;33936100;33968037;33981976;34019948;34087483;34171305;34357683;34433824;34509645;34725712;35051231;35083852;35154160;35251023;35874702;36010968;36215666;36241641;36284347;36580660;37074911;37217939;38665916;3905801;39245686;3938630;40596516;6307276;6809411;710450;8197205;9054364;9545296;9560306;9582318;9989503",
        "class_list": "",
        "function": "Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype., [RefSeq, PubMed]; Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication., [RefSeq, PubMed]; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Peptidyl-prolyl cis-trans isomerase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding., [UniProtKB, PubMed]; The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K534;Q6IBH5;Q9BVK5",
        "ec_number_list": "5.2.1.8;1.14.11.7",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0051082 unfolded protein binding;GO:0070063 RNA polymerase binding;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity",
        "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0044829 host-mediated activation of viral genome replication;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0060348 bone development;GO:0044794 host-mediated activation of viral process",
        "synthesized_glycan_count": 0,
        "hit_score": 17.9,
        "record_id": "P23284-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P45877-1",
        "uniprot_id": "PPIC_HUMAN",
        "mass": 22763.0,
        "length": 212,
        "protein_name": "Peptidyl-prolyl cis-trans isomerase C",
        "gene_name": "PPIC",
        "organism": "Human",
        "refseq_name": "peptidyl-prolyl cis-trans isomerase C precursor",
        "refseq_ac": "NP_000934",
        "gene_names_uniprotkb": "PPIC; CYPC",
        "gene_names_refseq": "CYPC; PPIC",
        "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase C; 5.2.1.8; Cyclophilin C; PPIase C; Rotamase C",
        "protein_names_refseq": "PPIase C; cyclophilin C; parvulin; peptidyl-prolyl cis-trans isomerase C precursor; peptidyl-prolyl cis-trans isomerase C; rotamase C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5480)",
        "pathway_count": 1,
        "publication_count": 28,
        "publication_id_list": "10.1101/2023.09.13.557529;20068231;20676357;24990953;26691022;27801851;28834231;29242379;29741879;29786170;29790264;30429286;32125861;32157095;32161166;32350084;33592498;33968037;33981976;34087483;34725712;35051231;35251023;36241641;36284347;37209796;38665916;8031755",
        "class_list": "",
        "function": "Cyclophilin C as a Novel Diagnostic and Prognostic Biomarker of Coronary Artery Diseases. A Systematic Review and Meta-Analysis., [RefSeq, PubMed]; Cyclophilin C participates in cytomegalovirus US2 protein-mediated degradation of major histocompatibility complex class I molecules. Publication Status: Online-Only, [RefSeq, PubMed]; Independent validation with glioma patients tissue (n = 70) and normal brain tissue (n = 19) found PPIC, EMP3 and CHI3L1 were up-regulated in glioma tissue. Survival value validation showed that the three genes correlated with patient survival by Kaplan-Meir analysis, including grades, age and therapy. Publication Status: Online-Only, [RefSeq, PubMed]; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding., [UniProtKB, PubMed]; The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]., [RefSeq]; These findings establish cyclophilin C as an ER cyclophilin, demonstrate the novel involvement of cyclophilins B and C in ER redox homeostasis, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4LBB5",
        "ec_number_list": "5.2.1.8",
        "go_molecular_function": "GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006457 protein folding",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "P45877-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P62745-1",
        "uniprot_id": "RHOB_HUMAN",
        "mass": 22123.0,
        "length": 196,
        "protein_name": "Rho-related GTP-binding protein RhoB",
        "gene_name": "RHOB",
        "organism": "Human",
        "refseq_name": "rho-related GTP-binding protein RhoB",
        "refseq_ac": "NP_004031",
        "gene_names_uniprotkb": "RHOB; ARH6; ARHB",
        "gene_names_refseq": "ARH6; ARHB; MST081; MSTP081; RHOB; RHOH6",
        "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoB; 3.6.5.2; Rho cDNA clone 6; h6",
        "protein_names_refseq": "Aplysia RAS-related homolog 6; h6; oncogene RHO H6; ras homolog gene family, member B; rho cDNA clone 6; rho-related GTP-binding protein RhoB",
        "tax_id": 9606,
        "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); neurodegenerative disease (Disease Ontology:DOID:1289); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); ulcerative colitis (Disease Ontology:DOID:8577)",
        "pathway": " (hsa:388);  (R-HSA-114604);  (R-HSA-416482);  (R-HSA-416572);  (R-HSA-5625740);  (R-HSA-5625900);  (R-HSA-5627117);  (R-HSA-5663220);  (R-HSA-5666185);  (R-HSA-9013026)",
        "pathway_count": 10,
        "publication_count": 232,
        "publication_id_list": "10026222;10330186;10469124;10508588;10591629;10600384;10619026;10652353;10678165;10753910;10873388;10924361;10940294;10958683;11018042;11134534;11207612;11262396;11283606;11294240;11313914;11313932;11331307;11481033;11546812;11742120;11942626;12101119;12123608;12185584;12196628;12220504;12221077;12221096;12429848;12433842;12473120;12515866;12577064;12730235;12732141;12783890;12802051;12805219;12813055;12832405;1400319;14514689;15003508;15006353;15085137;15184667;15210733;15226397;15507212;15699075;15708849;15749160;15767687;15791647;15864301;15866170;15944396;15951850;16112081;16174766;16202622;16212495;16219803;16236794;16292343;16431929;16439214;16622419;16622420;16776779;16896804;16917499;16923326;16938345;16943183;16979770;17030981;17129783;17151359;17198702;17301291;1737036;17616532;17932950;18001770;18006505;18025083;18097444;18218625;18374420;18577758;18589439;18590726;1874735;18802007;18923426;18955485;19212140;19350017;19409513;19700402;19713215;19723632;19815554;19850008;20030946;20101212;20591975;21148482;21351730;21373644;21397845;21454492;21576392;21749319;21868368;22094460;22267732;22275430;22293177;22608513;22661716;22673745;22790947;22911862;22992742;23222643;23255595;23444367;23716662;23801653;24128008;24141704;24905543;24914801;25414122;25673874;26024233;26992070;27072905;27452731;27481945;27503856;27600516;27807006;27862975;27920218;28228285;2841328;28649982;28736554;28832583;28904123;29242379;29314611;29331515;29358211;29393594;29493099;29508533;29557506;29632711;2966156;29774024;29786170;30007591;30297842;30315122;30429286;31020640;31154438;31522999;31844290;31848261;31871319;32161166;32350084;3283705;32938616;33123756;33592498;33968037;34357683;35051231;35580925;36114582;36996579;3839510;38753591;3888408;39042337;39336777;7537292;7624799;7713879;7721814;7937899;8246984;8543060;8571126;8617235;8617742;8662509;8662891;8673706;8702756;8816443;8939998;8986718;8990121;9028946;9278512;9308960;9354661;9438848;9478917;9649308;9768361;9792683;9796816;9822605;9870942;9870943;9889122;9895304;9988689",
        "class_list": "",
        "function": "Downregulation of RhoB Inhibits Cervical Cancer Progression and Enhances Cisplatin Sensitivity. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MiR-21-5p knockdown inhibits epithelial to mesenchymal transition in A549 lung adenocarcinoma cells by upregulating RhoB. Publication Status: Online-Only, [RefSeq, PubMed]; PITPNA-AS1 Inhibits Cell Proliferation and Migration in Ovarian Cancer by Regulating the MIR-223-3p/RHOB Axis. Publication Status: Online-Only, [RefSeq, PubMed]; RhoB affects colitis through modulating cell signaling and intestinal microbiome. Publication Status: Online-Only, [RefSeq, PubMed]; RhoB as a tumor suppressor: It's all about localization., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R692;P01121;Q5U0H6;Q7RTN5;Q7RTR9;Q9CUV7",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;2.7.11.1;2.7.11.39;3.6.1.5;2.7.10.1;3.6.1.-;3.6.5.4;3.1.3.53;3.1.3.16;3.6.4.-;2.7.11.13;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0007015 actin filament organization;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0015031 protein transport",
        "synthesized_glycan_count": 0,
        "hit_score": 23.5,
        "record_id": "P62745-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H4E5-1",
        "uniprot_id": "RHOJ_HUMAN",
        "mass": 23821.0,
        "length": 214,
        "protein_name": "Rho-related GTP-binding protein RhoJ",
        "gene_name": "RHOJ",
        "organism": "Human",
        "refseq_name": "rho-related GTP-binding protein RhoJ",
        "refseq_ac": "NP_065714",
        "gene_names_uniprotkb": "RHOJ; ARHJ; RASL7B; RHOI; TCL",
        "gene_names_refseq": "ARHJ; RASL7B; RHOJ; TC10B; TCL",
        "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoJ; 3.6.5.2; Ras-like protein family member 7B; Tc10-like GTP-binding protein",
        "protein_names_refseq": "RAS-like, family 7, member B; TC10-like Rho GTPase; ras homolog gene family, member J; ras-like protein family member 7B; rho-related GTP-binding protein RhoJ; tc10-like GTP-binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57381);  (R-HSA-9013409)",
        "pathway_count": 2,
        "publication_count": 24,
        "publication_id_list": "10967094;11237011;12456725;12960428;15304341;15710388;21148427;21628409;22971344;23029280;23255595;24434213;26299518;27481945;27660391;29557506;29786170;30158707;31844290;31871319;32302585;34119829;37781036;38247865",
        "class_list": "",
        "function": "Our study supports a novel role for the Rho family member RhoJ in ednothelial cell morphogenesis and in particular in lumen formation, [RefSeq, PubMed]; Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707). Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707)., [UniProtKB, PubMed, PubMed, PubMed]; RHOJ Induces Epithelial-to-Mesenchymal Transition by IL-6/STAT3 to Promote Invasion and Metastasis in Gastric Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Repression of RhoJ expression promotes TGF-beta-mediated EMT in human non-small-cell lung cancer A549cells., [RefSeq, PubMed]; RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers., [RefSeq, PubMed]; TCL is essential for clathrin-dependent endocytosed receptors to enter the early/sorting endosomes Erratum:[Mol Biol Cell. 2004 Apr;15(4):preceding table of contents], [RefSeq, PubMed]; This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]., [RefSeq]; Towards Understanding the Development of Breast Cancer: The Role of RhoJ in the Obesity Microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96KC1",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;2.3.2.26;3.6.5.5;3.6.1.5;2.7.11.1;3.6.1.-;3.6.5.4;3.1.3.86;3.1.3.56;3.1.3.36;1.16.1.-;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0030036 actin cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q9H4E5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92922-1",
        "uniprot_id": "SMRC1_HUMAN",
        "mass": 122867.0,
        "length": 1105,
        "protein_name": "SWI/SNF complex subunit SMARCC1",
        "gene_name": "SMARCC1",
        "organism": "Human",
        "refseq_name": "SWI/SNF complex subunit SMARCC1",
        "refseq_ac": "NP_003065",
        "gene_names_uniprotkb": "SMARCC1; BAF155",
        "gene_names_refseq": "BAF155; CRACC1; HYC5; Rsc8; SMARCC1; SRG3; SWI3",
        "protein_names_uniprotkb": "SWI/SNF complex subunit SMARCC1; BAF155; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1",
        "protein_names_refseq": "SWI/SNF complex 155 kDa subunit; SWI/SNF complex subunit SMARCC1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; chromatin remodeling complex BAF155 subunit; mammalian chromatin remodeling complex BRG1-associated factor 155",
        "tax_id": 9606,
        "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); colorectal carcinoma (Disease Ontology:DOID:0080199); hydrocephalus (Disease Ontology:DOID:10908); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); Coffin-Siris syndrome (Disease Ontology:DOID:1925); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); hydrocephalus, congenital, 5, susceptibility to (MONDO:MONDO:0859376)",
        "pathway": " (hsa:6599);  (R-HSA-3214858);  (R-HSA-8939243);  (R-HSA-9824585);  (R-HSA-9845323);  (R-HSA-9933937);  (R-HSA-9933939);  (R-HSA-9933946);  (R-HSA-9933947);  (R-HSA-9934037)",
        "pathway_count": 10,
        "publication_count": 199,
        "publication_id_list": "10.1101/2023.09.13.557529;10078207;10587587;11018012;11237011;11238380;11341840;11448779;11532965;11747826;11751582;11756452;11856727;11964381;12062444;12368262;12917342;1321344;15144186;15302935;1537333;1537334;15485929;15543135;15640446;15695812;15729346;15985610;16083285;16265664;16303920;16917507;17081983;17182843;17215844;17287340;17322306;17498659;17640523;17898714;17952075;18079182;18212344;18404153;18452278;18483556;18669648;18695000;18697795;18765789;18767875;18809673;18812475;19007248;19234465;19389701;19413330;19415658;19608861;19651622;19664995;19690332;19691289;19717472;20068231;20111005;20112406;20166139;20305658;20506188;20829358;20951943;21316606;21406692;21555454;21740066;21774791;22231400;22325351;22424782;22464331;22952240;23186163;23301498;23481700;23644491;23785148;24267888;24275569;24366607;24715725;25218447;25418920;25505266;25576301;25645385;25755297;25892735;26154972;26365797;26375851;26601204;26694611;26992070;27600516;27846572;27920218;28063628;28218747;28228285;28510447;28514659;28533407;28649982;28753627;28832583;28834231;28904123;29242379;29374058;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29983323;30192525;30315122;30410026;30429286;30484775;30515787;30524438;31217245;31844290;32119511;32157095;32265295;32350084;32357974;32387766;32417234;32459350;32488085;32502341;32897882;32938616;32983136;33077954;33100333;33141586;33214551;33298915;33392160;33465208;33592498;33633747;33691108;33717175;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34465901;34509645;34932366;35051231;35138101;35154160;35251023;35318648;35561310;35580127;35580925;36010968;36241641;36581221;37285932;37639281;38128548;38359823;38665916;40596516;40914422;7813420;8306979;8804307;8921401;9642256;9744861;9758418;9891079",
        "class_list": "",
        "function": "A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus., [RefSeq, PubMed]; First reports of fetal SMARCC1 related hydrocephalus. Review article, [RefSeq, PubMed]; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; SMARCC1 is a susceptibility gene for congenital hydrocephalus with an autosomal dominant inheritance mode and incomplete penetrance., [RefSeq, PubMed]; The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 10,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q17RS0;Q6P172;Q8IWH2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0042393 histone binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex",
        "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 20.6,
        "record_id": "Q92922-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16613-1",
        "uniprot_id": "SNAT_HUMAN",
        "mass": 23344.0,
        "length": 207,
        "protein_name": "Serotonin N-acetyltransferase",
        "gene_name": "AANAT",
        "organism": "Human",
        "refseq_name": "serotonin N-acetyltransferase isoform 2",
        "refseq_ac": "NP_001079",
        "gene_names_uniprotkb": "AANAT; SNAT",
        "gene_names_refseq": "AANAT; DSPS; SNAT",
        "protein_names_uniprotkb": "Serotonin N-acetyltransferase; 2.3.1.87; AA-NAT; Aralkylamine N-acetyltransferase; Serotonin acetylase",
        "protein_names_refseq": "arylalkylamine N-acetyltransferase; serotonin N-acetyltransferase isoform 2; serotonin acetylase",
        "tax_id": 9606,
        "disease": "advanced sleep phase syndrome (Disease Ontology:DOID:0050628); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:15);  (R-HSA-209931)",
        "pathway_count": 2,
        "publication_count": 19,
        "publication_id_list": "11237011;11313340;11336675;11427721;12379098;12511643;12736803;1540578;15644438;16869299;18212399;2590185;33392160;34184492;34763165;38753969;39894887;7989373;8661026",
        "class_list": "",
        "function": "Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin., [UniProtKB, PubMed]; Downregulation of AANAT by c-Fos in tubular epithelial cells with membranous nephropathy., [RefSeq, PubMed]; The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]., [RefSeq]; There is a significant increase in AANAT allele positivity at the single nucleotide polymorphism (alanine 129--> threonine) at between patients with DSPS & controls.  AA-NAT could be a susceptibility gene for DSPS. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Variation in the AA-NAT gene G203A is associated with Awassi and Hamdani sheep fertility., [RefSeq, PubMed]; [Association of polymorphic variants of DDC (AADC), AANAT and ASMT genes encoding enzymes for melatonin synthesis with the higher risk of neuropsychiatric disorders].', trans 'Assotsiatsiya polimorfizmov genov DDC (AADC), AANAT i ASMT, kodiruyushchikh fermenty sinteza melatonina, s riskom razvitiya psikhonevrologicheskikh rasstroistv. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
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        "reported_phosphosites": 4,
        "reported_mutagensis": 1,
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        "reported_snv": 3,
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        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVF2;J3KMZ5;Q562F4",
        "ec_number_list": "2.3.1.87",
        "go_molecular_function": "GO:0071889 14-3-3 protein binding;GO:0004060 arylamine N-acetyltransferase activity;GO:0004059 aralkylamine N-acetyltransferase activity;GO:0008080 N-acetyltransferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0010043 response to zinc ion;GO:0051592 response to calcium ion;GO:0071320 cellular response to cAMP;GO:0007623 circadian rhythm;GO:0032868 response to insulin",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q16613-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60248-1",
        "uniprot_id": "SOX15_HUMAN",
        "mass": 25251.0,
        "length": 233,
        "protein_name": "Transcription factor SOX-15",
        "gene_name": "SOX15",
        "organism": "Human",
        "refseq_name": "transcription factor SOX-15",
        "refseq_ac": "NP_008873",
        "gene_names_uniprotkb": "SOX15; SOX12; SOX20; SOX26; SOX27",
        "gene_names_refseq": "SOX15; SOX20; SOX26; SOX27",
        "protein_names_uniprotkb": "Transcription factor SOX-15; Protein SOX-12; Protein SOX-20; SRY-box transcription factor 15",
        "protein_names_refseq": "SRY (sex determining region Y)-box 15; SRY (sex determining region Y)-box 20; SRY-box 15; protein SOX-15; transcription factor SOX-15",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6665)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "19664994;19664995;21406692;30379171;31848261;32416168;32938616;34603557;35922412;37096504;39098847;8332506;8978787;9540826;9880678",
        "class_list": "",
        "function": "CircVPS8 promotes the malignant phenotype and inhibits ferroptosis of glioma stem cells by acting as a scaffold for MKRN1, SOX15 and HNF4A., [RefSeq, PubMed]; Epigenetic Silencing of SOX15 Is Controlled by miRNAs rather than Methylation in Papillary Thyroid Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; SOX15 transcriptionally increases the function of AOC1 to modulate ferroptosis and progression in prostate cancer. Publication Status: Online-Only, [RefSeq, PubMed]; These data demonstrate that SOX15 functions as a potential tumor-suppressor in glioma by inhibiting cell proliferation and invasion via the downregulation of Wnt/beta-catenin signaling, [RefSeq, PubMed]; This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity). Acts as a transcriptional activator and repressor (By similarity). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity). Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (By similarity). Regulates transcription of HRC via binding to it proximal enhancer region (By similarity). Involved in skeletal muscle regeneration (By similarity). Also plays a role in the development of myogenic precursor cells (By similarity)., [UniProtKB, UniProtKB]; [The Mechanism of miR-1294 Targeting SOX15 to Regulate Wnt/beta-catenin Signaling Pathway and Promote the Proliferation of Acute Lymphoblastic Leukemia Cells in Children]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
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        "secondary_ac_list": "B4DWU7;D3DTQ0;P35717;Q9Y6W7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "O60248-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P1J9-1",
        "uniprot_id": "CDC73_HUMAN",
        "mass": 60577.0,
        "length": 531,
        "protein_name": "Parafibromin",
        "gene_name": "CDC73",
        "organism": "Human",
        "refseq_name": "parafibromin",
        "refseq_ac": "NP_078805",
        "gene_names_uniprotkb": "CDC73; C1orf28; HRPT2",
        "gene_names_refseq": "C1orf28; CDC73; FIHP; HPTJT; HRPT1; HRPT2; HYX",
        "protein_names_uniprotkb": "Parafibromin; Cell division cycle protein 73 homolog; Hyperparathyroidism 2 protein",
        "protein_names_refseq": "Familial isolated hyperparathyroidism; cell division cycle 73 Paf1/RNA polymerase II complex component-like protein; cell division cycle 73, Paf1/RNA polymerase II complex component, homolog; cell division cycle protein 73 homolog; hyperparathyroidism 2 protein; parafibromin",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hyperparathyroidism (Disease Ontology:DOID:13543); parathyroid carcinoma (Disease Ontology:DOID:1540); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); lung adenocarcinoma (Disease Ontology:DOID:3910); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:79577);  (R-HSA-112382);  (R-HSA-201722);  (R-HSA-5632684);  (R-HSA-674695);  (R-HSA-75955);  (R-HSA-8866654);  (R-HSA-9920588);  (R-HSA-9943411)",
        "pathway_count": 9,
        "publication_count": 314,
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        "class_list": "",
        "function": "By purifying cellular parafibromin and characterizing its associated proteins, a human counterpart to the yeast Paf1 complex including homologs of Leo1, Paf1, and Ctr9, has been described., [RefSeq, PubMed]; Human parafibromin is a nucleocytoplasmic tumor suppressor protein which regulates cyclin D1/PRAD1 expression., [RefSeq, PubMed]; Para This, Fibromin That: The Role of CDC73 in Parathyroid Tumors and Familial Tumor Syndromes. Review article, [RefSeq, PubMed]; Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis., [RefSeq, PubMed]; The clinicopathological and prognostic significances of CDC73 expression in breast cancer: A pathological and bioinformatics analysis., [RefSeq, PubMed]; This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]., [RefSeq]; Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
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        "biomarker_type": "",
        "glycan_count": 6,
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        "secondary_ac_list": "A6NLZ8;B2RBR2;Q6PK51;Q96A07;Q9H245;Q9H5L7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000993 RNA polymerase II complex binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016593 Cdc73/Paf1 complex;GO:0000781 chromosome, telomeric region",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050680 negative regulation of epithelial cell proliferation;GO:0071222 cellular response to lipopolysaccharide",
        "synthesized_glycan_count": 0,
        "hit_score": 32.4,
        "record_id": "Q6P1J9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96T75-1",
        "uniprot_id": "DSCR8_HUMAN",
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        "length": 97,
        "protein_name": "Down syndrome critical region protein 8",
        "gene_name": "DSCR8",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DSCR8; C21orf65; MTAG2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Down syndrome critical region protein 8; CT25; Cancer/testis antigen 25; DCR1-24.0; MMA-1; Malignant melanoma-associated protein 1; Protein MTAG2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
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        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "11920614;12036297;12213769;15472897;39394480",
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        "secondary_ac_list": "Q684H4;Q6EXA9;Q8N3X0;Q8NDY5;Q96B46",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
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        "hit_score": 0.6,
        "record_id": "Q96T75-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14964-1",
        "uniprot_id": "RB39A_HUMAN",
        "mass": 25007.0,
        "length": 217,
        "protein_name": "Ras-related protein Rab-39A",
        "gene_name": "RAB39A",
        "organism": "Human",
        "refseq_name": "ras-related protein Rab-39A",
        "refseq_ac": "NP_059986",
        "gene_names_uniprotkb": "RAB39A; RAB39",
        "gene_names_refseq": "K28; RAB39A; RAB39",
        "protein_names_uniprotkb": "Ras-related protein Rab-39A; 3.6.5.2; Rab-39",
        "protein_names_refseq": "RAB39, member RAS oncogene family; rab-39; rab-related GTP-binding protein; ras-related protein Rab-39A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54734);  (R-HSA-6811438);  (R-HSA-8873719);  (R-HSA-8876198)",
        "pathway_count": 4,
        "publication_count": 256,
        "publication_id_list": "10189370;10652308;10652516;10818110;10990452;11038176;11141079;11179213;11389151;11447212;11516400;11675392;11689439;11703925;11718716;11746448;11748249;11784320;11917121;12011112;12058051;12221131;12244319;12364329;12383348;12427552;12429822;12475894;12684051;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15504911;15528189;15561770;15692570;15718469;15728195;15758030;15878329;15914536;15958533;16207721;16373702;16401880;16410077;1648736;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17114793;17132146;17189207;17208202;17239822;17274799;17287728;17411337;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18086915;18094055;18256213;18354496;18367545;18451304;1845915;18477474;18532927;18559336;18585354;18664496;18701652;18779367;18804435;1900457;19109890;19164740;19345684;19403694;19490898;19536132;19603039;19620288;19656848;19715559;19725050;19729655;19745841;19833722;20008558;20154091;20159109;20159556;20163571;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20874812;20937701;21041651;2115402;21183348;21187289;21216617;21255211;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21807881;21951725;22013193;22065758;22072793;22171327;22188167;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22694141;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378023;23378591;23420520;23444368;23462996;23478338;23481700;23645161;23678941;23684622;23713133;23839779;23936529;23940353;24023390;24119662;24296415;24349490;24644286;24694596;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25472813;25648148;25708460;25713415;25925668;26055712;26163492;26177209;26245486;26434594;26538022;26925400;26936971;26969162;27041585;27044746;27103185;27246931;27329675;27494456;29242379;29648608;31844290;33298915;33912179;34357683;35580925;37217939;37821429;7688123;7911226;7957092;7991565;8144603;8164745;8349690;8375503;8408203;8513495;8522602;8631982;8636227;8662963;8836150;8863739;8945478;9020086;9020161;9030515;9119394;9136770;9244307;9323142;9476900;9510256;9590177;9653114;9707577;9733780;9915833",
        "class_list": "",
        "function": "C9ORF72 causes suboptimal autophagy Review article, [RefSeq, PubMed]; Molecular pathways regulated by RAB39A are transcriptionally maintained by the formation of molecular complex with RXRB, NCOR and HDAC that also contribute to cancer stemness. Review article, [RefSeq, PubMed]; Our findings indicate that Rab39a favours chlamydial replication and infectivity. This is the first report showing that a late endocytic Rab GTPase is involved in chlamydial infection development., [RefSeq, PubMed]; Results show that Rab39a interacts with caspase-1 and suggest that Rab39a functions as a trafficking adaptor linking caspase-1 to IL-1beta secretion. Erratum:[J Biol Chem. 2016 Nov 18;291(47):24800. doi: 10.1074/jbc.A109.046102. PMID: 27864526], [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21255211). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21255211). RAB39A regulates autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex onto lysosomes; this process involves lysosomal RAB39A and autophagosomal RAB2A recruitment of HOPS subcomplexes VPS41-VPS16-VPS18-VPS33A and VPS39-VPS11, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Also negatively regulates lipopolysaccharide (LPS)-induced autophagosome formation in macrophages, possibly by implicating PI3K (PubMed:24349490). Promotes the delivery of MHC-I molecules from the ER to phagosomes and the generation of peptide-loaded MHC-I complexes in phagosomes, thus enhancing antigen cross-presentation by dendritic cells (By similarity). Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). May be involved in multiple neurite formation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KAA4;Q8N6W2",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.1.-;2.5.1.60;3.6.5.4;2.7.11.1;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane",
        "go_biological_process": "GO:0090383 phagosome acidification;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0032482 Rab protein signal transduction;GO:0090385 phagosome-lysosome fusion",
        "synthesized_glycan_count": 0,
        "hit_score": 25.9,
        "record_id": "Q14964-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15428-1",
        "uniprot_id": "SF3A2_HUMAN",
        "mass": 49256.0,
        "length": 464,
        "protein_name": "Splicing factor 3A subunit 2",
        "gene_name": "SF3A2",
        "organism": "Human",
        "refseq_name": "splicing factor 3A subunit 2",
        "refseq_ac": "NP_009096",
        "gene_names_uniprotkb": "SF3A2; SAP62",
        "gene_names_refseq": "PRP11; PRPF11; SAP62; SF3A2; SF3a66",
        "protein_names_uniprotkb": "Splicing factor 3A subunit 2; SAP 62; SF3a66; Spliceosome-associated protein 62",
        "protein_names_refseq": "SAP 62; pre-mRNA splicing factor SF3A, subunit 2; spliceosome associated protein 62; splicing factor 3A subunit 2; splicing factor 3a, subunit 2, 66kDa; splicing factor 3a, subunit 2, 66kD",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8175);  (R-HSA-72163);  (R-HSA-9770562);  (R-HSA-9918481);  (R-HSA-9943411)",
        "pathway_count": 5,
        "publication_count": 204,
        "publication_id_list": "10199952;10669729;10882114;11014198;11060040;11101529;11233976;11237011;11533230;11747608;11991638;12176931;12411573;12414731;12477934;12682017;14519844;14625303;14713954;14749727;14762106;15037765;15084397;15565158;15647753;16263726;16314458;16372014;16809785;17095540;17128255;17332742;17433364;17606899;17717186;18042460;18288197;18322460;18593880;19103666;19165350;19217410;19536130;20068231;20211137;20423332;20695905;20980672;21295486;21349847;21536652;2176635;21911577;22046413;22110043;22121020;22365833;22569126;22813749;22922743;22959432;22961380;23186163;23222130;23236153;23345524;23481700;23874216;24076191;24149845;24196718;24304693;24448447;24715725;24737827;24914973;25301780;25301781;25555158;25576301;2558966;25880248;26092250;26385511;26420826;26969736;26992070;27108190;27377154;27459055;27543614;27661449;27683217;27862975;27920218;28062851;28076346;28096519;28228285;28502770;28781166;28832583;28834231;28911096;29186539;29242379;29274231;29301961;29360106;29361316;29393594;29493099;29508533;29557506;29632046;29632711;2963332;29786170;29789417;29902443;30139799;30192525;30257008;30315122;30315277;30410026;30429286;30524438;30599162;30705154;30728453;30765414;30779550;30833945;30975767;31092671;31217245;31373491;31409651;31530632;31844290;31848261;32157095;32161166;32179686;32265295;32329775;32350084;32357974;32387766;32488085;32494006;32502341;32816001;32897882;32938616;33177556;33214551;33243851;33298915;33392160;33446560;33592498;33691108;33717175;33936100;33968037;33981976;34019948;34171305;34301950;34357683;34509645;34561969;34822310;34846842;34932366;35051231;35177536;35215846;35251023;35385551;35580925;36010968;36241641;36797247;3757028;37938771;38665916;40596516;40914422;8211113;8566756;8608946;9016565;9242493;9512519;9524131;9539711;9659921;9671485;9701291;9710584;9731529",
        "class_list": "",
        "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29360106, PubMed:29361316, PubMed:30315277). Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBU1;D6W605;O75245",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0010976 positive regulation of neuron projection development;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 20.9,
        "record_id": "Q15428-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15427-1",
        "uniprot_id": "SF3B4_HUMAN",
        "mass": 44386.0,
        "length": 424,
        "protein_name": "Splicing factor 3B subunit 4",
        "gene_name": "SF3B4",
        "organism": "Human",
        "refseq_name": "splicing factor 3B subunit 4",
        "refseq_ac": "NP_005841",
        "gene_names_uniprotkb": "SF3B4; SAP49",
        "gene_names_refseq": "AFD1; Hsh49; SAP49; SF3B4; SF3b49",
        "protein_names_uniprotkb": "Splicing factor 3B subunit 4; Pre-mRNA-splicing factor SF3b 49 kDa subunit; SAP 49; Spliceosome-associated protein 49",
        "protein_names_refseq": "SAP 49; SF3b50; pre-mRNA-splicing factor SF3b 49 kDa subunit; spliceosomal protein; spliceosome-associated protein (U2 snRNP); spliceosome-associated protein 49; splicing factor 3B subunit 4; splicing factor 3b, subunit 4, 49kDa; splicing factor 3b, subunit 4, 49kD",
        "tax_id": 9606,
        "disease": "pancreatic cancer (Disease Ontology:DOID:1793); cervical cancer (Disease Ontology:DOID:4362); Nager acrofacial dysostosis (Disease Ontology:DOID:5768); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:10262);  (R-HSA-72163);  (R-HSA-72165);  (R-HSA-9770562);  (R-HSA-9918481);  (R-HSA-9943411)",
        "pathway_count": 6,
        "publication_count": 235,
        "publication_id_list": "10199952;10207048;10669729;10882114;11014198;11060040;11101529;11233976;11237011;11333026;11607023;11747608;11991638;12176931;12234937;12411573;12414731;12477934;12682017;12738865;14519844;14625303;14713954;14749727;14762106;15037765;15084397;15146077;15565158;15592455;15647753;16263726;16314458;16372014;16809785;17095540;17128255;17332742;17433364;17606899;17717186;17940139;18042460;18083107;18288197;18322460;18593880;18991276;19052544;19103666;19165350;19217410;19536130;20068231;20211137;20423332;20695905;20980672;21295486;21536652;2176635;21911577;22046413;22110043;22121020;22223895;22365833;22424782;22541558;22569126;22813749;22922743;22959432;22961380;23222130;23236153;23301498;23345524;23481700;23874216;24076191;24149845;24196718;24304693;24448447;24715725;24737827;24914973;2524422;25301780;25301781;25555158;25576301;2558966;25645385;25737013;25880248;26092250;26154972;26385511;26420826;26811146;26969736;26992070;27108190;27377154;27397612;27459055;27510544;27600516;27661449;27683217;27720643;27846572;27862975;27920218;28062851;28076346;28096519;28218747;28228285;28502770;28510447;28541300;28649982;28781166;28832583;28834231;28855257;28904123;28911096;29186539;29242379;29274231;29301961;29331515;29360106;29361316;29393594;29493099;29508533;29557506;29632711;2963332;29786170;29902443;30139799;30257008;30315122;30315277;30429286;30524438;30599162;30705154;30728453;30765414;30833945;30975767;31092671;31154438;31222486;31409651;31530632;31844290;31848261;31937595;32157095;32161166;32179686;32329775;32350084;32357974;32387766;32488085;32494006;32502341;32816001;32897882;32938616;32983136;33123756;33141586;33177556;33243851;33298915;33392160;33446560;33509932;33537174;33592498;33691108;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34301950;34357683;34405274;34822310;34932366;35051231;35154160;35177536;35215846;35251023;35318648;35385551;35561310;35580925;36010968;36241641;36284347;36797247;37217939;3757028;37938771;38665916;39467623;40930100;7958871;8566756;8608946;8835860;9016565;9242493;9512519;9524131;9539711;9659921;9671485;9701291;9731529",
        "class_list": "",
        "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:12234937, PubMed:27720643, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SF3B4 Regulates Cellular Senescence and Suppresses Therapy-induced Senescence of Cancer Cells., [RefSeq, PubMed]; This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5SZ63",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:1990935 splicing factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome",
        "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 23.8,
        "record_id": "Q15427-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96MN9-1",
        "uniprot_id": "ZN488_HUMAN",
        "mass": 36962.0,
        "length": 340,
        "protein_name": "Zinc finger protein 488",
        "gene_name": "ZNF488",
        "organism": "Human",
        "refseq_name": "zinc finger protein 488",
        "refseq_ac": "NP_001333861",
        "gene_names_uniprotkb": "ZNF488",
        "gene_names_refseq": "ZNF488",
        "protein_names_uniprotkb": "Zinc finger protein 488",
        "protein_names_refseq": "zinc finger protein 488",
        "tax_id": 9606,
        "disease": "",
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        "publication_id_list": "33968037;36537752",
        "class_list": "",
        "function": "Transcription factor ZNF488 accelerates cervical cancer progression through regulating the MEK/ERK signaling pathway., [RefSeq, PubMed]; Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury., [UniProtKB, UniProtKB]",
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        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0006355 regulation of DNA-templated transcription;GO:0014003 oligodendrocyte development;GO:0031643 positive regulation of myelination",
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        "gene_name": "LOC128071547",
        "organism": "Human",
        "refseq_name": "uncharacterized LOC128071547",
        "refseq_ac": "NP_001401824",
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        "protein_names_refseq": "uncharacterized LOC128071547",
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    },
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        "length": 20,
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        "gene_name": "LOC128092251",
        "organism": "Human",
        "refseq_name": "uncharacterized LOC128092251",
        "refseq_ac": "NP_001401871",
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        "length": 68,
        "protein_name": "Uncharacterized protein",
        "gene_name": "LOC128071544",
        "organism": "Human",
        "refseq_name": "uncharacterized LOC128071544",
        "refseq_ac": "NP_001401821",
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        "gene_names_refseq": "LOC128071544",
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        "protein_names_refseq": "uncharacterized LOC128071544",
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    },
    {
        "uniprot_canonical_ac": "Q8ND07-1",
        "uniprot_id": "BBOF1_HUMAN",
        "mass": 61987.0,
        "length": 529,
        "protein_name": "Basal body-orientation factor 1",
        "gene_name": "BBOF1",
        "organism": "Human",
        "refseq_name": "basal body-orientation factor 1",
        "refseq_ac": "NP_079333",
        "gene_names_uniprotkb": "BBOF1; C14orf45; CCDC176",
        "gene_names_refseq": "BBOF1; C14orf45; CCDC176; FBB10",
        "protein_names_uniprotkb": "Basal body-orientation factor 1; Coiled-coil domain-containing protein 176",
        "protein_names_refseq": "basal body-orientation factor 1; coiled-coil domain containing 176; coiled-coil domain-containing protein 176",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80127)",
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        "publication_id_list": "11237011;29242379;29485866;32983136;33392160",
        "class_list": "",
        "function": "Plays an essential role in sperm motility and male fertility by stabilizing the sperm flagellar axonemal structure. May be required for the stability of ODF2 and MANS1 proteins. Dispensable for the assembly and function of motile cilia., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q0P604;Q9H5P8",
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0036064 ciliary basal body",
        "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0044458 motile cilium assembly;GO:0007288 sperm axoneme assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8ND07-1",
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    },
    {
        "uniprot_canonical_ac": "Q8NFU1-1",
        "uniprot_id": "BEST2_HUMAN",
        "mass": 57139.0,
        "length": 509,
        "protein_name": "Bestrophin-2a",
        "gene_name": "BEST2",
        "organism": "Human",
        "refseq_name": "bestrophin-2a",
        "refseq_ac": "NP_060152",
        "gene_names_uniprotkb": "BEST2; VMD2L1",
        "gene_names_refseq": "BEST2; VMD2L1",
        "protein_names_uniprotkb": "Bestrophin-2a; Vitelliform macular dystrophy 2-like protein 1",
        "protein_names_refseq": "VMD2-like gene 1; bestrophin-2a; vitelliform macular dystrophy 2-like 1; vitelliform macular dystrophy 2-like protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54831);  (R-HSA-2672351)",
        "pathway_count": 2,
        "publication_count": 98,
        "publication_id_list": "10.1101/2023.09.13.557529;10564087;10642508;10720933;10767424;10830164;10831588;11182090;11237011;11588175;11687798;11734858;11842292;11904445;11956057;12032738;12393854;12907679;1379744;14584882;14634667;15010458;15044642;15147738;15318163;15504734;15505377;15916532;15919655;16219661;16813530;16849430;16850186;17381423;17448995;17699613;17881003;18000046;18063579;18310267;18400985;18449189;18508966;18662336;18724360;19153159;19307298;19380724;19387438;19620632;19808995;19953639;20388639;20407206;20466723;20525693;20538786;21040849;21527911;21984732;22002868;22773952;22946059;2298749;23112050;2321095;23616951;24223998;2536303;26359375;26562072;28071645;28154142;28790369;29393594;29557506;32251414;34185709;34902511;35789156;36289327;7588753;7665160;7795595;8041726;8112288;8383669;8533761;8544406;8626462;8809036;9037075;9395096;9571199;9662395;9700209;9719863;9744806",
        "class_list": "",
        "function": "BEST2 and BEST4 could be added to the lineage-specific genes of humans intestinal epithelial cells Publication Status: Online-Only, [RefSeq, PubMed]; Forms calcium-sensitive chloride channels. Permeable to bicarbonate., [UniProtKB, UniProtKB]; Identified three novel VMD2-related human genes demonstrating a high degree of conservation in their respective RFP-TM domains [VMD2L1, VMD2L2, VMD2L3], [RefSeq, PubMed]; Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+) (PubMed:11904445, PubMed:18400985, PubMed:32251414, PubMed:35789156, PubMed:36289327). Transports a large specter of anions, namely mediates the movement of chloride, L-glutamate and iodide (PubMed:11904445, PubMed:18400985, PubMed:32251414, PubMed:35789156, PubMed:36289327). Calcium-binding triggers the dilation of the aperture, but calcium-dependent gating is only effective when the size of the passing anion is bigger than the closed aperture (By similarity). Mediates the calcium-activated hydrogencarbonate movement and participates in colonic hydrogencarbonate secretion concomitant with mucin secretion (By similarity). In non-pigmented epithelium (NPE), mediates the efflux of intracellular L-glutamate; binding of intracellular L-glutamate activates and open both the neck and the aperture of the channel, leading to L-glutamate exit promoting chloride influx movement from the extracellular side in trans (PubMed:36289327). Also exhibits a directional permeability for intracellular glutamine, in a similar manner as for L-glutamate (PubMed:36289327)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Low expression of bestrophin-2 is associated with poor prognosis in colon cancer., [RefSeq, PubMed]; This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q53YQ8;Q9NXP0",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0005254 chloride channel activity;GO:0005217 intracellularly ligand-gated monoatomic ion channel activity;GO:0099094 ligand-gated monoatomic cation channel activity;GO:0160133 bicarbonate channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016323 basolateral plasma membrane;GO:0034707 chloride channel complex",
        "go_biological_process": "GO:0051899 membrane depolarization;GO:1902476 chloride transmembrane transport;GO:0007608 sensory perception of smell",
        "synthesized_glycan_count": 0,
        "hit_score": 10.1,
        "record_id": "Q8NFU1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96DT6-1",
        "uniprot_id": "ATG4C_HUMAN",
        "mass": 52497.0,
        "length": 458,
        "protein_name": "Cysteine protease ATG4C",
        "gene_name": "ATG4C",
        "organism": "Human",
        "refseq_name": "cysteine protease ATG4C",
        "refseq_ac": "NP_116241",
        "gene_names_uniprotkb": "ATG4C; APG4C; AUTL1; AUTL3",
        "gene_names_refseq": "APG4-C; APG4C; ATG4C; AUTL1; AUTL3; HsAPG4C",
        "protein_names_uniprotkb": "Cysteine protease ATG4C; 3.4.22.-; AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; HsAPG4C",
        "protein_names_refseq": "APG4 autophagy 4 homolog C; ATG4 autophagy related 4 homolog C; AUT-like 1, cysteine endopeptidase; AUT-like 3 cysteine endopeptidase; autophagin-3; autophagy-related cysteine endopeptidase 3; autophagy-related protein 4 homolog C; cysteine protease ATG4C; epididymis secretory sperm binding protein",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:84938);  (R-HSA-1632852)",
        "pathway_count": 2,
        "publication_count": 80,
        "publication_id_list": "11096062;11237011;11825910;12446702;15187094;16963840;17618624;18321988;18439900;19211835;19322194;19590496;19855179;19898463;20059746;20713597;20921139;21177865;21205641;21258367;21383122;21460621;21819378;22170151;22248718;22682742;23186163;23202584;23301498;23685627;23727157;23884233;24747438;24954904;25418920;25484072;25568151;25892735;26154972;26375851;26811146;26992070;27600516;27920218;28218747;28649982;28832583;28834231;28904123;29242379;29393594;29458288;29632046;29769354;30379171;30410026;30429286;30661429;31154438;31217245;31844290;31848261;32157095;32265295;32350084;32401768;32488085;33717175;33773106;33909989;33968037;34561969;34619495;34699312;34932366;35051231;35251023;35580925;36284347;7628435",
        "class_list": "",
        "function": "ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system., [RefSeq, PubMed]; Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]., [RefSeq]; CAV1 and ATG4C serve as useful prognostic biomarkers and candidate therapeutic targets in EOC Publication Status: Online-Only, [RefSeq, PubMed]; Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Epigallocatechin-3-gallate protects cardiomyocytes from hypoxia-reoxygenation damage via raising autophagy related 4C expression., [RefSeq, PubMed]; MiR-376b controls autophagy by directly regulating intracellular levels of two key autophagy proteins, ATG4C and BECN1., [RefSeq, PubMed]; MicroRNA-142-3p inhibits autophagy and promotes intracellular survival of Mycobacterium tuberculosis by targeting ATG16L1 and ATG4c., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NLR8;D3DQ58;Q96K04",
        "ec_number_list": "3.4.22.-",
        "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity;GO:0019786 protein-phosphatidylethanolamide deconjugating activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006508 proteolysis;GO:0015031 protein transport;GO:0016485 protein processing;GO:0006914 autophagy",
        "synthesized_glycan_count": 0,
        "hit_score": 8.3,
        "record_id": "Q96DT6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BPU9-1",
        "uniprot_id": "B9D2_HUMAN",
        "mass": 19261.0,
        "length": 175,
        "protein_name": "B9 domain-containing protein 2",
        "gene_name": "B9D2",
        "organism": "Human",
        "refseq_name": "B9 domain-containing protein 2",
        "refseq_ac": "NP_085055",
        "gene_names_uniprotkb": "B9D2; MKSR2",
        "gene_names_refseq": "B9D2; ICIS-1; JBTS34; MKS10; MKSR-2; MKSR2",
        "protein_names_uniprotkb": "B9 domain-containing protein 2; MKS1-related protein 2",
        "protein_names_refseq": "B9 domain-containing protein 2; B9 protein domain 2; MKS1-related protein 2; involved in cIlia stability-1",
        "tax_id": 9606,
        "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); ciliopathy (Disease Ontology:DOID:0060340); Meckel syndrome 10 (Disease Ontology:DOID:0061295)",
        "pathway": " (hsa:80776);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5620912);  (R-HSA-5663220);  (R-HSA-68877);  (R-HSA-9648025)",
        "pathway_count": 9,
        "publication_count": 138,
        "publication_id_list": "10411507;10600384;10678165;10958683;11081627;11181178;11237011;11371342;11509732;11535616;11804586;12006501;12194817;12429848;12577064;12679384;12732141;12805219;12852857;14730319;15006353;15085137;15339662;15507212;15723797;15737063;15864301;15866170;15944396;16292343;16357211;16439214;16541025;16622419;16622420;16682347;16890222;16943183;17030981;17112726;17113138;17127412;17129783;17196341;17198702;1737036;17574030;17646400;17719545;18001770;18037885;18097444;18694559;18716626;18801063;18923426;19004860;19081074;19208769;19350017;19692168;19696148;19815554;19940019;19965387;20030946;20101212;20230748;20308558;20399632;20558667;20591975;21111234;21148482;21273506;21397845;21422230;21548880;21565611;21576392;21620453;21725307;21763481;21792235;21868368;21878504;21987589;22094460;22179047;22275430;22433857;22608513;22653444;22790947;22885700;23141531;23141541;23222643;23253480;23348840;23400999;23530209;23747070;23769972;23789104;23801653;24053599;24089205;24231678;24469809;24914801;24982133;25047611;25313408;25418920;25740311;25789526;25892735;26092869;28832583;29242379;29769354;31409757;31411728;31844290;32157095;32357974;33592498;33717175;33936100;33968037;34260926;35051231;36010968;39455645;9649308;9649503;9892021",
        "class_list": "",
        "function": "Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes., [UniProtKB, PubMed]; MKS-1 and MKS-1-related proteins 1 and 2 (MKSR-1/EPPB9, MKSR-2/B9D2), localize to transition zones/basal bodies of sensory cilia; subcellular localization is largely co-dependent, pointing to a functional relationship between the proteins, [RefSeq, PubMed]; New functions of B9D2 in tight junctions and epithelial polarity. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The ICIS-1 (Involved in CIlia Stability-1)gene is localized within the TGF-beta1 promoter and is upregulated during mucociliary differentiation. GeneRIF: ICIS-1 is a new protein associated with ciliated cells and potentially related to cilia stability.  This gene is localized within the TGF-beta1 promoter and is ubiquitously expressed in human tissues. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a B9 domain protein, which are exclusively found in ciliated organisms. The gene is upregulated during mucociliary differentiation, and the encoded protein localizes to basal bodies and cilia. Disrupting expression of this gene results in ciliogenesis defects. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0043015 gamma-tubulin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0005930 axoneme",
        "go_biological_process": "GO:0060271 cilium assembly;GO:1904491 protein localization to ciliary transition zone;GO:0030030 cell projection organization",
        "synthesized_glycan_count": 0,
        "hit_score": 13.9,
        "record_id": "Q9BPU9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00512-1",
        "uniprot_id": "BCL9_HUMAN",
        "mass": 149290.0,
        "length": 1426,
        "protein_name": "B-cell CLL/lymphoma 9 protein",
        "gene_name": "BCL9",
        "organism": "Human",
        "refseq_name": "B-cell CLL/lymphoma 9 protein",
        "refseq_ac": "NP_004317",
        "gene_names_uniprotkb": "BCL9",
        "gene_names_refseq": "BCL9; LGS",
        "protein_names_uniprotkb": "B-cell CLL/lymphoma 9 protein; B-cell lymphoma 9 protein; Bcl-9; Protein legless homolog",
        "protein_names_refseq": "B cell CLL/lymphoma 9; B-cell CLL/lymphoma 9 protein; B-cell lymphoma 9 protein; bcl-9; protein legless homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:607);  (R-HSA-201722);  (R-HSA-3769402)",
        "pathway_count": 3,
        "publication_count": 129,
        "publication_id_list": "10080941;10485845;10549281;10769018;10775268;10831834;10898789;10921920;10944533;11050151;11080158;11136974;11237011;11532957;11691915;11713476;11934263;11955446;11973335;11988739;12163411;12408824;12408825;12712206;14600025;14685266;14695187;15060161;15121853;15132997;15294866;15302935;15327769;15525529;15768032;15829968;16005293;16169192;16510874;16630820;16756492;17052462;17218525;17322306;17412698;17425782;17428831;17458864;17525332;17698607;17875931;18077418;18160704;18347063;18378692;18404694;18456656;18491316;18498752;18573912;18598779;18669648;18819930;19047045;19148484;19364920;19413330;19415658;19460168;19487454;19493659;19571879;19590513;19664994;19664995;19690332;19928349;19940019;20068231;21406692;21654818;21726809;22186018;22190459;22304967;22617422;22982193;23186163;23301498;23481700;24275569;24291232;25645385;26992070;27600516;27846572;28228285;28834231;30192525;30315122;30379171;30429286;30620550;31154438;31217245;31844290;32157095;32488085;33862557;33968037;33974352;34019948;34545187;35027586;35051231;35254053;36803362;37541260;38665916;39302247;8756721;8757136;8955148;9118222;9488439;9490669;9751710;9819412;9843967",
        "class_list": "",
        "function": "BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]., [RefSeq]; Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy number amplification in squamous cell lung cancer., [RefSeq, PubMed]; Hypoxia-inducible factor 1alpha induces osteo/odontoblast differentiation of human dental pulp stem cells via Wnt/beta-catenin transcriptional cofactor BCL9. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity)., [UniProtKB, PubMed]; LncRNA NCK1-AS1 exerts oncogenic property in gastric cancer by targeting the miR-22-3p/BCL9 axis to activate the Wnt/beta-catenin signaling., [RefSeq, PubMed]; Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma., [RefSeq, PubMed]; The interactions of Bcl9/Bcl9L with beta-catenin and Pygopus promote breast cancer growth, invasion, and metastasis., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 54,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T489",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008013 beta-catenin binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005801 cis-Golgi network;GO:1990907 beta-catenin-TCF complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060070 canonical Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 13.4,
        "record_id": "O00512-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43520-1",
        "uniprot_id": "AT8B1_HUMAN",
        "mass": 143695.0,
        "length": 1251,
        "protein_name": "Phospholipid-transporting ATPase IC",
        "gene_name": "ATP8B1",
        "organism": "Human",
        "refseq_name": "phospholipid-transporting ATPase IC isoform 1",
        "refseq_ac": "NP_001361314",
        "gene_names_uniprotkb": "ATP8B1; ATPIC; FIC1; PFIC",
        "gene_names_refseq": "ATP8B1; ATPIC; BRIC; FIC1; ICP1; PFIC1; PFIC",
        "protein_names_uniprotkb": "Phospholipid-transporting ATPase IC; 7.6.2.1; ATPase class I type 8B member 1; Familial intrahepatic cholestasis type 1; P4-ATPase flippase complex alpha subunit ATP8B1",
        "protein_names_refseq": "ATPase, aminophospholipid transporter, class I, type 8B, member 1; ATPase, class I, type 8B, member 1; E1-E2 ATPase; P4-ATPase flippase complex alpha subunit ATP8B1; familial intrahepatic cholestasis type 1; phospholipid-transporting ATPase IC isoform 1; phospholipid-transporting ATPase IC; probable phospholipid-transporting ATPase IC",
        "tax_id": 9606,
        "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221); progressive familial intrahepatic cholestasis 1 (Disease Ontology:DOID:0070226); intrahepatic cholestasis of pregnancy 1 (Disease Ontology:DOID:0070228); benign recurrent intrahepatic cholestasis (Disease Ontology:DOID:0070230); benign recurrent intrahepatic cholestasis 1 (Disease Ontology:DOID:0070231); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); intrahepatic cholestasis (Disease Ontology:DOID:1852); acanthosis nigricans (Disease Ontology:DOID:3138); cataract (Disease Ontology:DOID:83); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:5205);  (R-HSA-936837)",
        "pathway_count": 2,
        "publication_count": 84,
        "publication_id_list": "10401004;10484781;10615129;10767338;11093741;11237011;15239083;15657619;15831496;15888793;15919184;15925480;16182249;1656976;16700898;16959974;17948906;18723824;19345671;19731236;19878721;20038848;20510206;20512993;20947505;20961850;2160952;21914794;22186024;23196729;23197899;24392018;25239307;25315773;25576301;26992070;27067231;27301931;27862975;28832583;28904123;29242379;29331515;29393594;29557506;29789417;30429286;30779550;30833945;31154438;31324691;31848261;32157095;32350084;32387766;32488085;33592498;33936100;33968037;34171305;34185709;34357683;35051231;35318648;35494241;35580925;35894240;36284347;36293199;36581221;36794287;37938771;37980352;6832622;7626145;8045293;8298639;8490646;8490659;9147644;9307043;9500542;9548971;9918928",
        "class_list": "",
        "function": "ATP8B1 Deficiency Results in Elevated Mitochondrial Phosphatidylethanolamine Levels and Increased Mitochondrial Oxidative Phosphorylation in Human Hepatoma Cells. Publication Status: Online-Only, [RefSeq, PubMed]; ATP8B1: A prognostic prostate cancer biomarker identified via genetic analysis., [RefSeq, PubMed]; Activation and substrate specificity of the human P4-ATPase ATP8B1. Publication Status: Online-Only, [RefSeq, PubMed]; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (PubMed:17948906, PubMed:25315773). May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (By similarity). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (By similarity). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity (PubMed:20512993). Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 (PubMed:25239307, PubMed:27301931). Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (By similarity). Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine (PubMed:20510206). Required for the preservation of cochlear hair cells in the inner ear (By similarity). May act as cardiolipin transporter during inflammatory injury (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Clinical phenotype of adult-onset liver disease in patients with variants in ABCB4, ABCB11, and ATP8B1., [RefSeq, PubMed]; This gene encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 12,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BTP8",
        "ec_number_list": "7.6.2.1;7.6.2.2",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090554 phosphatidylcholine floppase activity;GO:0090556 phosphatidylserine floppase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0005802 trans-Golgi network",
        "go_biological_process": "GO:0015721 bile acid and bile salt transport;GO:0034220 monoatomic ion transmembrane transport;GO:0045892 negative regulation of DNA-templated transcription;GO:0045332 phospholipid translocation;GO:0007605 sensory perception of sound",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "O43520-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60909-1",
        "uniprot_id": "B4GT2_HUMAN",
        "mass": 41972.0,
        "length": 372,
        "protein_name": "Beta-1,4-galactosyltransferase 2",
        "gene_name": "B4GALT2",
        "organism": "Human",
        "refseq_name": "beta-1,4-galactosyltransferase 2 isoform b",
        "refseq_ac": "NP_001005417",
        "gene_names_uniprotkb": "B4GALT2",
        "gene_names_refseq": "B4GALT2; B4Gal-T2; B4Gal-T3; beta4Gal-T2",
        "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 2; 2.4.1.-; 2.4.1.22; 2.4.1.38; 2.4.1.90; Beta-1,4-GalTase 2; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; Beta4Gal-T2; Lactose synthase A protein; N-acetyllactosamine synthase; Nal synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2; b4Gal-T2",
        "protein_names_refseq": "N-acetyllactosamine synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 2; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2; beta-1,4-GalTase 2; beta-1,4-galactosyltransferase 2 isoform b; beta-4-GalT2; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 2; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; lactose synthase A protein; nal synthase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8704);  (R-HSA-2022854);  (R-HSA-975577)",
        "pathway_count": 3,
        "publication_count": 56,
        "publication_id_list": "10206952;10395745;10491328;10504389;10570912;10580128;10700233;10766765;11030741;11042166;11042394;11237011;11283017;11421344;11425186;11530204;11588157;11821425;11901181;12097641;12218059;12603328;12765789;15486459;15560372;15620693;15939404;16434023;16924681;17006639;17021253;1714903;17488527;18931531;19403558;19524017;20117844;26811146;27004849;29242379;30020015;32350084;32387766;32938616;32983136;33592498;35051231;38034954;8333853;8611500;8920913;9054414;9405390;9405439;9417100;9597550",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Data show that Beta4-Gal-transferase (beta4GalT) extends core 2 and forms the backbone structure for biologically important epitopes., [RefSeq, PubMed]; In individuals under dual antiplatelet therapy, B4GALT2 c.909C>T is an independent genetic predictor of on-treatment platelet reactivity., [RefSeq, PubMed]; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids (PubMed:9405390). Can produce lactose (PubMed:9405390)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Study provides evidence that mutations in B3GNT2, B4GALT2, and ST6GALNAC2 underlie aberrant glycosylation, and contribute to the pathogenesis of molecular subsets of colon and other gastrointestinal malignancies. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 352,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KTP0;B4DE14;D3DPY6;D3DPY7;O60511;Q4V9L9;Q5T4X5;Q5T4Y5;Q9BUP6;Q9NSY7",
        "ec_number_list": "2.4.1.-;2.4.1.274;2.4.1.275;2.4.1.38;2.4.1.90;2.4.1.22",
        "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945 N-acetyllactosamine synthase activity;GO:0004461 lactose synthase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process",
        "synthesized_glycan_count": 10444,
        "hit_score": 5.7,
        "record_id": "O60909-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O96024-1",
        "uniprot_id": "B3GT4_HUMAN",
        "mass": 41537.0,
        "length": 378,
        "protein_name": "Beta-1,3-galactosyltransferase 4",
        "gene_name": "B3GALT4",
        "organism": "Human",
        "refseq_name": "beta-1,3-galactosyltransferase 4 precursor",
        "refseq_ac": "NP_003773",
        "gene_names_uniprotkb": "B3GALT4; GALT4",
        "gene_names_refseq": "B3GALT4; BETA3GALT4; GALT2; GALT4",
        "protein_names_uniprotkb": "Beta-1,3-galactosyltransferase 4; 2.4.1.62; Beta-1,3-GalTase 4; Beta3Gal-T4; Beta3GalT4; Gal-T2; GalT4; Ganglioside galactosyltransferase; UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase; b3Gal-T4",
        "protein_names_refseq": "UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase 4; UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4; UDP-galactose:beta-N-acetyl-galactosamine-beta-1, 3-galactosyltransferase; b3Gal-T4; beta-1,3-GalTase 4; beta-1,3-galactosyltransferase 4 precursor; beta-3-galactosyltransferase 4; gal-T2; ganglioside galactosyltransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8705);  (R-HSA-9037629);  (R-HSA-9840309)",
        "pathway_count": 3,
        "publication_count": 70,
        "publication_id_list": "10206952;10212226;10601645;10663566;10748143;10993897;11018043;11283017;11956206;12107078;12222957;12668675;12678917;12815231;12888565;14688233;15158662;1520296;1601877;16934889;1702034;17123352;1716630;1740457;1977660;20547865;20594196;2118655;21519903;22735313;23290777;23481700;23746551;23882130;24498430;24953560;27846572;28832583;28904123;29242379;29802621;30131660;30372681;30611881;31154438;31848261;32157095;32161166;32938616;32983136;33592498;34932366;34982351;35251023;7876235;7890749;8207002;8240337;8288606;8333853;8643456;8830034;8910600;8920913;9030544;9125199;9199191;9219535;9582303;9822625",
        "class_list": "glycogene;glycosyltransferase",
        "function": "B3GALT4 knockdown decreases GM1 ganglioside level and enhances vulnerability for neurodegeneration., [RefSeq, PubMed]; Colorectal cancer (CRC) patients expressing both high B7-H3 and high B3GALT4 contributed to a significant decrease in overall survival. The expression of B3GALT4 in CRC is positively correlated with B7-H3 expression in vitro. B7-H3/B3GLAT4 may be used as dual prognostic biomarkers for CRC., [RefSeq, PubMed]; Data showed that GM1/GD1b/GA1 synthase transfectant cells had definite reduction in cell growth and invasion., [RefSeq, PubMed]; In patients with late-onset Alzheimer disease, a number of differentially methylated postitions were hypomethylated in B3GALT4 compared with controls., [RefSeq, PubMed]; Induction of GM1a/GD1b synthase triggers complex ganglioside expression and alters neuroblastoma cell behavior; a new tumor cell model of ganglioside function, [RefSeq, PubMed]; Involved in GM1/GD1B/GA1 ganglioside biosynthesis., [UniProtKB, PubMed]; This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 398,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "2.4.1.86;2.4.1.62;2.4.1.-",
        "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity;GO:0047915 ganglioside galactosyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane",
        "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0009101 glycoprotein biosynthetic process;GO:0009312 oligosaccharide biosynthetic process;GO:0001574 ganglioside biosynthetic process",
        "synthesized_glycan_count": 300,
        "hit_score": 7.1,
        "record_id": "O96024-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0C853-1",
        "uniprot_id": "BAAS2_HUMAN",
        "mass": 11579.0,
        "length": 105,
        "protein_name": "Putative uncharacterized protein BAALC-AS2",
        "gene_name": "BAALC-AS2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "BAALC-AS2; BAALCOS; C8orf56",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein BAALC-AS2; BAALC antisense RNA 2; BAALC antisense gene protein 2; BAALC opposite strand protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P0C853-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P18850-1",
        "uniprot_id": "ATF6A_HUMAN",
        "mass": 74585.0,
        "length": 670,
        "protein_name": "Cyclic AMP-dependent transcription factor ATF-6 alpha",
        "gene_name": "ATF6",
        "organism": "Human",
        "refseq_name": "cyclic AMP-dependent transcription factor ATF-6 alpha isoform 1",
        "refseq_ac": "NP_031374",
        "gene_names_uniprotkb": "ATF6",
        "gene_names_refseq": "ACHM7; ATF6A; ATF6; ATP6alpha",
        "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-6 alpha; ATF6-alpha; Activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha",
        "protein_names_refseq": "cAMP-dependent transcription factor ATF-6 alpha; cyclic AMP-dependent transcription factor ATF-6 alpha isoform 1; cyclic AMP-dependent transcription factor ATF-6 alpha",
        "tax_id": 9606,
        "disease": "achromatopsia 7 (Disease Ontology:DOID:0110009); borna disease (Disease Ontology:DOID:5154)",
        "pathway": " (hsa:22926);  (R-HSA-380994);  (R-HSA-381033);  (R-HSA-381183);  (R-HSA-9909505)",
        "pathway_count": 5,
        "publication_count": 142,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10564271;10856300;10958673;11158310;11163209;11237011;11483355;11779464;11821395;12110171;12782636;14699159;14742429;14973138;15299016;15385533;15657421;16687408;16912112;16931790;16989641;17765680;18022401;18057259;18285520;18650380;18840095;19667116;20022965;20219975;20361218;22682248;22802018;22819556;22978410;23269699;23481700;23584533;2377606;24190977;24715725;2516827;25418920;25505266;25576301;25645385;25813380;25880248;25892735;26029869;26063662;26101251;26154972;2663993;2664463;26811146;26992070;27600516;27846572;27920218;28228285;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29413899;29493099;29508533;29557506;29632046;29741879;29769354;29786170;30169894;30224801;30315122;30379171;30429286;30524438;30620550;31092671;31154438;31434731;31455651;31530632;31611695;31844290;31848261;31875558;31937595;31998317;32157095;32161166;32265295;32350084;32357974;32387766;3260265;32938616;32983136;33141586;33298915;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34509645;34623328;35051231;35154160;35251023;35254053;35318648;35494241;35580925;36010968;36215666;36241641;36284347;36581221;36739529;36793726;37074911;37938771;39134692;40136647;40596516;9271374;9837962",
        "class_list": "",
        "function": "ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo, [RefSeq, PubMed]; Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464)., [UniProtKB, PubMed, PubMed, PubMed]; Studies show that ATF6, rather than being a soluble nuclear protein, was an active transcription factor and synthesized as a transmembrane protein embedded in the ER., [RefSeq, PubMed]; The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The aim was to study the activation of ATF6 and Grp78 in transfected human epithelial cells expressing the DeltaF508-CFTR protein., [RefSeq, PubMed]; The rs2341471-G/G genotype of activating transcription factor 6 (ATF6) is the risk factor of type 2 diabetes in subjects with obesity or overweight., [RefSeq, PubMed]; This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]., [RefSeq]; Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR (PubMed:10564271, PubMed:11158310, PubMed:11163209, PubMed:11779464). Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') (PubMed:10564271, PubMed:11158310, PubMed:11779464). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (PubMed:10564271, PubMed:11158310, PubMed:11779464). May play a role in foveal development and cone function in the retina (PubMed:26029869)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 11,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 11,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 11,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 2,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15139;Q5VW62;Q6IPB5;Q9UEC9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 16.3,
        "record_id": "P18850-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P22557-1",
        "uniprot_id": "HEM0_HUMAN",
        "mass": 64633.0,
        "length": 587,
        "protein_name": "5-aminolevulinate synthase, erythroid-specific, mitochondrial",
        "gene_name": "ALAS2",
        "organism": "Human",
        "refseq_name": "5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform a precursor",
        "refseq_ac": "NP_000023",
        "gene_names_uniprotkb": "ALAS2; ALASE; ASB",
        "gene_names_refseq": "ALAS-E; ALAS2; ALASE; ANH1; ASB; SIDBA1; XLDPP; XLEPP; XLSA",
        "protein_names_uniprotkb": "5-aminolevulinate synthase, erythroid-specific, mitochondrial; 2.3.1.37; 5-aminolevulinic acid synthase 2; ALAS-E; Delta-ALA synthase 2; Delta-aminolevulinate synthase 2",
        "protein_names_refseq": "5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform a precursor; 5-aminolevulinate synthase, erythroid-specific, mitochondrial; 5-aminolevulinic acid synthase 2; aminolevulinate, delta-, synthase 2; delta-ALA synthase 2; delta-ALA synthetase; delta-aminolevulinate synthase 2; erythroid-specific delta-aminolevulinate synthase",
        "tax_id": 9606,
        "disease": "sideroblastic anemia 1 (Disease Ontology:DOID:0060063); erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); bilirubin metabolic disorder (Disease Ontology:DOID:2741); acute intermittent porphyria (Disease Ontology:DOID:3890); hemolytic anemia (Disease Ontology:DOID:583); sideroblastic anemia (Disease Ontology:DOID:8955)",
        "pathway": " (hsa:212);  (R-HSA-189451)",
        "pathway_count": 2,
        "publication_count": 64,
        "publication_id_list": "10029606;10577279;10706561;11032836;11032841;11175906;11237011;12031592;12393718;12474143;12773194;14643893;15235026;1570328;15863660;16121195;16176984;16258391;16446107;16540354;18760763;1939222;19731322;2050125;20705604;21252495;21309041;21653323;2263504;23467411;26375851;26992070;28228285;28649982;28832583;29242379;29557506;30315122;30484775;30524438;32499479;34171305;34411431;34490613;34492704;35051231;35580925;35637209;36215666;3805019;39202434;666752;6822570;7354069;7592565;8078902;8107717;8159699;8644733;8771201;9177788;9642238;9858242;9878253",
        "class_list": "",
        "function": "A synonymous coding variant that alters ALAS2 splicing and causes X-linked sideroblastic anemia., [RefSeq, PubMed]; Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:14643893). Catalytic activity is 65-75% of isoform 1 activity (PubMed:14643893)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Congenital sideroblastic anemia model due to ALAS2 mutation is susceptible to ferroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Key Genes FECH and ALAS2 under Acute High-Altitude Exposure: A Gene Expression and Network Analysis Based on Expression Profile Data. Publication Status: Online-Only, [RefSeq, PubMed]; Severe iron overload in a woman with homeostatic iron regulator (HFE) and a novel 5'-aminolevulinate synthase 2 (ALAS2) mutations: interactions of multiple genetic determinants., [RefSeq, PubMed]; The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 9,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3F0;A8K6C4;Q13735;Q5JZF5;Q8N6H3",
        "ec_number_list": "2.3.1.37",
        "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0003870 5-aminolevulinate synthase activity;GO:0016746 acyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0001666 response to hypoxia;GO:0006879 intracellular iron ion homeostasis;GO:0030218 erythrocyte differentiation;GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "P22557-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P59052-1",
        "uniprot_id": "B3AS1_HUMAN",
        "mass": 15706.0,
        "length": 145,
        "protein_name": "Putative uncharacterized protein B3GALT5-AS1",
        "gene_name": "B3GALT5-AS1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "B3GALT5-AS1; C21orf88",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein B3GALT5-AS1; B3GALT5 antisense RNA 1; B3GALT5 antisense gene protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "12036297;32207329",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "diagnostic",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0VDC1;Q547X5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "P59052-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P98198-1",
        "uniprot_id": "AT8B2_HUMAN",
        "mass": 137440.0,
        "length": 1209,
        "protein_name": "Phospholipid-transporting ATPase ID",
        "gene_name": "ATP8B2",
        "organism": "Human",
        "refseq_name": "phospholipid-transporting ATPase ID isoform b",
        "refseq_ac": "NP_001005855",
        "gene_names_uniprotkb": "ATP8B2; ATPID; KIAA1137",
        "gene_names_refseq": "ATP8B2; ATPID",
        "protein_names_uniprotkb": "Phospholipid-transporting ATPase ID; 7.6.2.1; ATPase class I type 8B member 2; P4-ATPase flippase complex alpha subunit ATP8B2",
        "protein_names_refseq": "36/8-9 fusion protein with epitope for anti-lectin antibody; ATPase, aminophospholipid transporter, class I, type 8B, member 2; ATPase, class I, type 8B, member 2; P4-ATPase flippase complex alpha subunit ATP8B2; phospholipid-transporting ATPase ID isoform b; phospholipid-transporting ATPase ID; probable phospholipid-transporting ATPase ID",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57198);  (R-HSA-936837)",
        "pathway_count": 2,
        "publication_count": 71,
        "publication_id_list": "10401004;10484781;10615129;10767338;12880872;15831496;15919184;15925480;16182249;1656976;16700898;18723824;19345671;19878721;20947505;20961850;2160952;22186024;23186163;23196729;23481700;24392018;24715725;25315773;25576301;26154972;26240149;26992070;27067231;28218747;28832583;28834231;28904123;29242379;29493099;29557506;29786170;30192525;30315122;30429286;31844290;32157095;32350084;32387766;32488085;32502341;32938616;32983136;33141586;33592498;33912179;33936100;33968037;33981976;34087483;34211107;34357683;34509645;35051231;35580925;36010968;36284347;38253038;6832622;7626145;8045293;8298639;8490646;8490659;9147644;9307043",
        "class_list": "",
        "function": "Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. May contribute to the maintenance of membrane lipid asymmetry., [UniProtKB, PubMed]; The predominant P4 ATPases in pure pancreatic beta cells and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A. ATP8B1 and CDC50A were highly concentrated in ISG, [RefSeq, PubMed]; The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A5K1VW70;B4E3P4;Q6NT69;Q7Z486;Q96I43;Q96NQ7",
        "ec_number_list": "7.6.2.1;7.6.2.2",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090554 phosphatidylcholine floppase activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005802 trans-Golgi network;GO:1990531 phospholipid-translocating ATPase complex",
        "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0045332 phospholipid translocation;GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 7.6,
        "record_id": "P98198-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q12934-1",
        "uniprot_id": "BFSP1_HUMAN",
        "mass": 74544.0,
        "length": 665,
        "protein_name": "Filensin",
        "gene_name": "BFSP1",
        "organism": "Human",
        "refseq_name": "filensin isoform 2",
        "refseq_ac": "NP_001155177",
        "gene_names_uniprotkb": "BFSP1",
        "gene_names_refseq": "BFSP1; CP115; CP94; CTRCT33; LIFL-H",
        "protein_names_uniprotkb": "Filensin; Beaded filament structural protein 1; CP115; LIFL-H; Lens fiber cell beaded-filament structural protein CP 115; Lens intermediate filament-like heavy",
        "protein_names_refseq": "beaded filament structural protein 1, filensin; cytoskeletal protein, 115 KD; filensin isoform 2; lens fiber cell beaded-filament structural protein CP 115; lens intermediate filament-like heavy",
        "tax_id": 9606,
        "disease": "cataract 33 (Disease Ontology:DOID:0110264)",
        "pathway": " (hsa:631)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "10909854;17225135;24379646;28450710;28935373;30620550;30790544;31530632;32157095;32983136;33968037;34171305;35051231;37371051;7720401;9628810;9787085",
        "class_list": "",
        "function": "A novel mutation (c.1042G>A) at exon 7 of BFSP1, which creates a substitution of an aspartate to an asparagine (p.D348N) was identified to be associated with autosomal dominant congenital cataract in a Chinese family. Publication Status: Online-Only, [RefSeq, PubMed]; Independent Membrane Binding Properties of the Caspase Generated Fragments of the Beaded Filament Structural Protein 1 (BFSP1) Involves an Amphipathic Helix. Publication Status: Online-Only, [RefSeq, PubMed]; Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (PubMed:28935373). Involved in altering the calcium regulation of MIP water permeability (PubMed:30790544)., [UniProtKB, PubMed, PubMed]; The results suggest that the N-terminal domain of CRYAA is required during in vitro complex formation with filensin and phakinin., [RefSeq, PubMed]; This gene encodes a lens-specific intermediate filament-like protein named filensin. The encoded protein is expressed in lens fiber cells after differentiation has begun. This protein functions as a component of the beaded filament which is a cytoskeletal structure found in lens fiber cells. Mutations in this gene are the cause of autosomal recessive cortical juvenile-onset cataract. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F5H0G1;O43595;O76034;O95676;Q8IVZ6;Q9HBX4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005212 structural constituent of eye lens",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0005882 intermediate filament",
        "go_biological_process": "GO:0045109 intermediate filament organization;GO:0070307 lens fiber cell development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q12934-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13705-1",
        "uniprot_id": "AVR2B_HUMAN",
        "mass": 57724.0,
        "length": 512,
        "protein_name": "Activin receptor type-2B",
        "gene_name": "ACVR2B",
        "organism": "Human",
        "refseq_name": "activin receptor type-2B precursor",
        "refseq_ac": "NP_001097",
        "gene_names_uniprotkb": "ACVR2B",
        "gene_names_refseq": "ACTRIIB; ACVR2B; ActR-IIB; HTX4",
        "protein_names_uniprotkb": "Activin receptor type-2B; 2.7.11.30; ACTR-IIB; Activin receptor type IIB",
        "protein_names_refseq": "activin A receptor, type IIB; activin receptor type-2B precursor; activin receptor type-2B",
        "tax_id": 9606,
        "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); juvenile polyposis syndrome (Disease Ontology:DOID:0050787); visceral heterotaxy 4 (Disease Ontology:DOID:0051019); right atrial isomerism (Disease Ontology:DOID:0060856); pre-eclampsia (Disease Ontology:DOID:10591); Marfan syndrome (Disease Ontology:DOID:14323)",
        "pathway": " (hsa:93);  (R-HSA-1181150);  (R-HSA-1433617);  (R-HSA-1502540);  (R-HSA-201451)",
        "pathway_count": 5,
        "publication_count": 91,
        "publication_id_list": "10.1101/2023.09.13.557529;10067895;10458166;10473623;10587654;10712517;10822381;10934479;11016919;11024047;11117535;11121043;11158580;11278251;11294908;11389842;11485994;11509558;11571290;11714695;11779503;11779505;12063393;12151385;12519765;12592392;12821673;12857866;12941698;14978253;15062104;15087470;15123686;15150278;15350224;15485907;15531507;16140969;16260601;16672363;17029022;17068149;17272273;17295905;17311849;17344846;17356069;17906079;18070108;18166170;18951876;19114992;20694664;21356369;21383881;21532621;22718755;25603319;29557506;31665064;31844290;32157095;32350084;33706404;33968037;34131275;34211107;34302448;34357683;35051231;35494241;7644468;7791754;8119126;8161782;8196624;8622651;8653785;8721982;8878477;8893010;9032295;9136927;9288972;9311995;9436979;9459292;9621519;9670020;9702198;9916847",
        "class_list": "",
        "function": "Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not Reliable Markers of Mild or Moderate Neonatal Hypoxic-Ischemic Encephalopathy., [RefSeq, PubMed]; Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]., [RefSeq]; Deficiency of myostatin protects skeletal muscle cells from ischemia reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; The association between sarcopenia susceptibility and polymorphisms of FTO, ACVR2B, and IRS1 in Tibetans., [RefSeq, PubMed]; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 9641,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VAV0",
        "ec_number_list": "2.7.11.30;2.3.2.26",
        "go_molecular_function": "GO:0019209 kinase activator activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0048179 activin receptor complex;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0001974 blood vessel remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0006879 intracellular iron ion homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q13705-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q58HT5-1",
        "uniprot_id": "AWAT1_HUMAN",
        "mass": 37759.0,
        "length": 328,
        "protein_name": "Acyl-CoA wax alcohol acyltransferase 1",
        "gene_name": "AWAT1",
        "organism": "Human",
        "refseq_name": "acyl-CoA wax alcohol acyltransferase 1",
        "refseq_ac": "NP_001013597",
        "gene_names_uniprotkb": "AWAT1; DGA2; DGAT2L3",
        "gene_names_refseq": "AWAT1; DGA2; DGAT2L3",
        "protein_names_uniprotkb": "Acyl-CoA wax alcohol acyltransferase 1; 2.3.1.75; Diacylglycerol O-acyltransferase 2-like protein 3; Diacylglycerol acyltransferase 2; Long-chain-alcohol O-fatty-acyltransferase 1",
        "protein_names_refseq": "acyl-CoA wax alcohol acyltransferase 1; diacyl-glycerol acyltransferase 2; diacylglycerol O-acyltransferase 2-like 3; diacylglycerol O-acyltransferase 2-like protein 3; diacylglycerol acyltransferase 2; long-chain-alcohol O-fatty-acyltransferase 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:158833);  (R-HSA-2142753);  (R-HSA-9640463)",
        "pathway_count": 3,
        "publication_count": 18,
        "publication_id_list": "14970677;15220348;15220349;15671038;15897321;16106050;17015445;19926788;21247147;21746768;28096191;28228285;29393594;29557506;31844290;35494241;6810878;7954810",
        "class_list": "",
        "function": "Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15671038). Shows a strong preference for decyl alcohol (C10), with less activity towards C16 and C18 alcohols (PubMed:15671038). Shows a strong preference for saturated acyl-CoAs (PubMed:15671038)., [UniProtKB, PubMed]; Analysis of AWAT1 and AWAT2 substrate specificity and differentiation-specific expression pattern, [RefSeq, PubMed]; The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JT21;Q6IEE4",
        "ec_number_list": "2.3.1.20;2.3.1.76;2.3.1.22;2.3.1.75;2.3.1.-",
        "go_molecular_function": "GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0010025 wax biosynthetic process;GO:0019369 arachidonate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q58HT5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5SQI0-1",
        "uniprot_id": "ATAT_HUMAN",
        "mass": 46810.0,
        "length": 421,
        "protein_name": "Alpha-tubulin N-acetyltransferase 1",
        "gene_name": "ATAT1",
        "organism": "Human",
        "refseq_name": "alpha-tubulin N-acetyltransferase 1 isoform 1",
        "refseq_ac": "NP_001026892",
        "gene_names_uniprotkb": "ATAT1; C6orf134; MEC17; Nbla00487",
        "gene_names_refseq": "ATAT1; C6orf134; MEC17; Nbla00487; alpha-TAT1; alpha-TAT",
        "protein_names_uniprotkb": "Alpha-tubulin N-acetyltransferase 1; 2.3.1.108; Acetyltransferase mec-17 homolog; Alpha-TAT1; Alpha-TAT; TAT",
        "protein_names_refseq": "acetyltransferase mec-17 homolog; alpha-tubulin N-acetyltransferase 1 isoform 1; alpha-tubulin N-acetyltransferase 1",
        "tax_id": 9606,
        "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)",
        "pathway": " (hsa:79969);  (R-HSA-5620920)",
        "pathway_count": 2,
        "publication_count": 60,
        "publication_id_list": "12024216;12880961;17084703;18180281;19081074;19823565;20603001;20829795;21068373;23071314;23071318;23110214;23186163;24097348;24129315;24715725;24906155;25576301;25645385;26768311;26992070;27600516;27846572;28228285;28832583;28834231;28904123;29242379;29557506;30429286;31154438;31844290;31848261;31998317;32157095;32387766;32488085;32897882;32938616;33141586;33298915;33592498;33691108;33968037;33981976;34087483;34171305;34199510;34405274;34508164;34509645;35051231;35580925;36010968;36215666;36241641;37938771;38652325;38835115;9427680",
        "class_list": "",
        "function": "AlphaTAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion., [RefSeq, PubMed]; Analysis reveals a basic patch implicated in substrate binding and a conserved glutamine residue required for catalysis, demonstrating that the family of alpha-tubulin acetyltransferases uses a reaction mechanism different from other lysine acetyltransferases, [RefSeq, PubMed]; Cysteine residues play important catalytic roles through a ternary complex mechanism. alphaTAT1 mutations have analogous effects on tubulin acetylation in vitro and in cells, [RefSeq, PubMed]; Genetic disruption of ATAT1 causes RhoA downregulation through abnormal truncation of C/EBPbeta., [RefSeq, PubMed]; Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress. Publication Status: Online-Only, [RefSeq, PubMed]; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly., [UniProtKB, PubMed, PubMed, PubMed, HAMAP, PubMed]; The alpha-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that localizes to clathrin-coated pits, where it acetylates alpha tubulin on lysine 40. This process may be important in microtubule growth, for instance during chemotaxis and the formation of cilium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 22,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2AB28;Q3LIB0;Q5JP39;Q5JP40;Q5JP42;Q5SQI1;Q5SU03;Q86X42;Q8NDK9;Q9BRS1;Q9H8X5",
        "ec_number_list": "3.6.5.-;2.3.1.108",
        "go_molecular_function": "GO:0004468 L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor;GO:0019799 tubulin N-acetyltransferase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0005905 clathrin-coated pit;GO:0005925 focal adhesion;GO:0030424 axon",
        "go_biological_process": "GO:0009612 response to mechanical stimulus;GO:0060271 cilium assembly;GO:0000226 microtubule cytoskeleton organization;GO:0048666 neuron development;GO:0048265 response to pain",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q5SQI0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UX72-1",
        "uniprot_id": "B3GN9_HUMAN",
        "mass": 43751.0,
        "length": 402,
        "protein_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9",
        "gene_name": "B3GNT9",
        "organism": "Human",
        "refseq_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9",
        "refseq_ac": "NP_171608",
        "gene_names_uniprotkb": "B3GNT9; PRO4397",
        "gene_names_refseq": "B3GNT9",
        "protein_names_uniprotkb": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9; 2.4.1.-; BGnT-9; Beta-1,3-Gn-T9; Beta-1,3-N-acetylglucosaminyltransferase 9; Beta3Gn-T9",
        "protein_names_refseq": "BGnT-9; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9; beta-1,3-Gn-T9; beta-1,3-N-acetylglucosaminyltransferase 9; beta-1,3-galactosyltransferase-related protein; beta3Gn-T9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84752);  (R-HSA-913709)",
        "pathway_count": 2,
        "publication_count": 35,
        "publication_id_list": "10.1038/emboj.2013.79;10330415;10430883;10753916;11042166;11283017;11304796;11821425;12855678;12975309;1329093;15486459;15560372;15620693;17113861;18537974;19913121;20628086;22183981;23584533;24643043;28467828;29557506;29789417;30459171;32350084;33592498;34171305;7655172;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 610,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96EK0",
        "ec_number_list": "2.4.1.-;2.4.1.147;2.4.1.149;2.4.1.206;2.4.1.146",
        "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0016758 hexosyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane",
        "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0030311 poly-N-acetyllactosamine biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q6UX72-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6Y288-1",
        "uniprot_id": "B3GLT_HUMAN",
        "mass": 56564.0,
        "length": 498,
        "protein_name": "Beta-1,3-glucosyltransferase",
        "gene_name": "B3GLCT",
        "organism": "Human",
        "refseq_name": "beta-1,3-glucosyltransferase precursor",
        "refseq_ac": "NP_919299",
        "gene_names_uniprotkb": "B3GLCT; B3GALTL; B3GTL",
        "gene_names_refseq": "B3GALTL; B3GLCT; B3GTL; B3Glc-T; Gal-T; beta3Glc-T",
        "protein_names_uniprotkb": "Beta-1,3-glucosyltransferase; 2.4.1.-; Beta 3-glucosyltransferase; Beta-3-glycosyltransferase-like; Beta3Glc-T",
        "protein_names_refseq": "UDP-GAL:beta-GlcNAc beta-1,3-galactosyltransferase-like; beta 1,3-galactosyltransferase-like; beta 3-glycosyltransferase-like; beta-1,3-glucosyltransferase precursor; beta-1,3-glucosyltransferase",
        "tax_id": 9606,
        "disease": "Peters plus syndrome (Disease Ontology:DOID:0080201)",
        "pathway": " (hsa:145173);  (R-HSA-5083635);  (R-HSA-5173214)",
        "pathway_count": 3,
        "publication_count": 27,
        "publication_id_list": "10.1101/2023.09.13.557529;11067851;12943678;16464858;16899492;16909395;18720094;18798333;19796186;22588082;23889335;25544610;27049305;32157095;32204707;32350084;32357974;32938616;32983136;34058199;34695439;35051231;35251023;35289036;35580925;36010968;37074911",
        "class_list": "glycogene;glycosyltransferase",
        "function": "B3GTL is transcribed in a wide range of tissues and has conserved domains and motifs, [RefSeq, PubMed]; Beta-1,3-glucosyltransferase involved in one of the two pathways responsible for protein O-linked fucosylation, a unique post-translational modification of cysteine-knotted proteins that regulates various biological processes. This pathway targets proteins with Thrombospondin type-1 (TSP1) repeats (TSR) in the endoplasmic reticulum. It starts with POFUT2, which attaches fucose via an O-glycosidic bond to a conserved serine or threonine residue. B3GLCT extends this modification by transferring a glucose molecule from UDP-glucose to the fucose., [UniProtKB, PubMed]; Biallelic truncating mutations in the beta 1,3-galactosyltransferase-like gene (B3GALTL) in all 20 tested patients, showed that Peters Plus is a monogenic, primarily single-mutation syndrome. Erratum:[Am J Hum Genet. 2006 Nov;79(5):985], [RefSeq, PubMed]; Loss of the AMD-associated B3GLCT gene affects glycosylation of TSP1 without impairing secretion in retinal pigment epithelial cells., [RefSeq, PubMed]; POFUT2 and B3GLCT mediate a noncanonical endoplasmic reticulum quality-control mechanism that recognizes folded thrombospondin type 1 repeats and stabilizes them by glycosylation., [RefSeq, PubMed]; Peters plus syndrome and Chorioretinal findings associated with B3GLCT gene mutation - a case report. Publication Status: Online-Only, [RefSeq, PubMed]; Peters plus syndrome mutations affect the function and stability of human beta1,3-glucosyltransferase., [RefSeq, PubMed]; Studies indicate that Peters Plus syndrome is caused by mutations in beta 3-glucosyltransferase (B3GALTL)., [RefSeq, PubMed]; The protein encoded by this gene is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS).[provided by RefSeq, Mar 2009]., [RefSeq]; We report here the molecular cloning and characterization of a novel beta1,3-glucosyltransferase (beta3Glc-T) that synthesizes a Glcbeta1,3Fucalpha- structure on the TSR domain., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 622,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5F8;Q5W0H2;Q6NUI3",
        "ec_number_list": "3.4.24.-;3.4.24.82;3.4.24.14;2.4.1.-;3.4.24.87",
        "go_molecular_function": "GO:0008375 acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity;GO:0160265 O-fucosylpeptide 3-beta-glucosyltransferase activity",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0036066 protein O-linked glycosylation via fucose;GO:0006004 fucose metabolic process",
        "synthesized_glycan_count": 6,
        "hit_score": 3.6,
        "record_id": "Q6Y288-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZU67-1",
        "uniprot_id": "BEND4_HUMAN",
        "mass": 58375.0,
        "length": 534,
        "protein_name": "BEN domain-containing protein 4",
        "gene_name": "BEND4",
        "organism": "Human",
        "refseq_name": "BEN domain-containing protein 4 isoform b",
        "refseq_ac": "NP_001153019",
        "gene_names_uniprotkb": "BEND4; CCDC4",
        "gene_names_refseq": "BEND4; CCDC4",
        "protein_names_uniprotkb": "BEN domain-containing protein 4; Coiled-coil domain-containing protein 4",
        "protein_names_refseq": "BEN domain-containing protein 4 isoform b; BEN domain-containing protein 4; coiled-coil domain containing 4; coiled-coil domain-containing protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:389206)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;17525332;23481700;28722770;29242379;29393594;30379171;32453508;33717175",
        "class_list": "",
        "function": "BEND4 hypermethylation is associated with lung cancer., [RefSeq, PubMed]; Genetic Variants May Play Role in Opioid Dependence., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A5D6;A1A5D7;C9JQZ5;Q58A26;Q58A27",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q6ZU67-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7RTS1-1",
        "uniprot_id": "BHA15_HUMAN",
        "mass": 20818.0,
        "length": 189,
        "protein_name": "Class A basic helix-loop-helix protein 15",
        "gene_name": "BHLHA15",
        "organism": "Human",
        "refseq_name": "class A basic helix-loop-helix protein 15",
        "refseq_ac": "NP_803238",
        "gene_names_uniprotkb": "BHLHA15; BHLHB8; MIST1",
        "gene_names_refseq": "BHLHA15; BHLHB8; MIST1",
        "protein_names_uniprotkb": "Class A basic helix-loop-helix protein 15; Class B basic helix-loop-helix protein 8; MIST-1; Muscle, intestine and stomach expression 1; bHLHa15; bHLHb8",
        "protein_names_refseq": "MIST-1; basic helix-loop-helix domain containing, class B, 8; class A basic helix-loop-helix protein 15; class B basic helix-loop-helix protein 8; class II bHLH protein MIST1; muscle, intestine and stomach expression 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:168620);  (R-HSA-9925561)",
        "pathway_count": 2,
        "publication_count": 27,
        "publication_id_list": "14516699;16645041;20038531;24715725;25576301;26992070;27058226;27846572;28832583;28834231;29242379;29371260;29557506;29786170;29789417;31827644;32161166;32502322;32938616;33109579;33537174;34171305;34185709;34932366;35318648;36168636;37938771",
        "class_list": "",
        "function": "Clinical Significance of Tumour CD44v and MIST1 Expression in Patients With Non-small-cell Lung Cancer., [RefSeq, PubMed]; DDX56 transcriptionally activates MIST1 to facilitate tumorigenesis of HCC through PTEN-AKT signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Diffuse MIST1 expression and decreased alpha1,4-linked N-acetylglucosamine (alphaGlcNAc) glycosylation on MUC6 are distinct hallmarks for gastric neoplasms showing oxyntic gland differentiation., [RefSeq, PubMed]; High MIST1 expression is associated with lymph node metastasis in Gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; MIST1 binds to highly conserved CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D., [RefSeq, PubMed]; Mist1 within the hierarchy of known helix-loop-helix/basic helix-loop-helix proteins that control mammary epithelial cell development, [RefSeq, PubMed]; Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D271;Q14DE4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0070888 E-box binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042149 cellular response to glucose starvation;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0010832 negative regulation of myotube differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q7RTS1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7RTU4-1",
        "uniprot_id": "BHA09_HUMAN",
        "mass": 24132.0,
        "length": 235,
        "protein_name": "Class A basic helix-loop-helix protein 9",
        "gene_name": "BHLHA9",
        "organism": "Human",
        "refseq_name": "class A basic helix-loop-helix protein 9",
        "refseq_ac": "NP_001157877",
        "gene_names_uniprotkb": "BHLHA9; BHLHF42",
        "gene_names_refseq": "BHLHA9; BHLHF42; CCSPD",
        "protein_names_uniprotkb": "Class A basic helix-loop-helix protein 9; Class F basic helix-loop-helix factor 42; bHLHa9; bHLHf42",
        "protein_names_refseq": "Fingerin; class A basic helix-loop-helix protein 9; class F basic helix-loop-helix factor 42; class II basic helix-loop-helix protein",
        "tax_id": 9606,
        "disease": "Camptosynpolydactyly, complex (MONDO:MONDO:0011853); mesoaxial synostotic syndactyly with phalangeal reduction (MONDO:MONDO:0012271); chromosome 17P13.3, telomeric, duplication syndrome (MONDO:MONDO:0012944)",
        "pathway": " (hsa:727857)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "14516699;22147889;23035971;24715725;25466284;27041388;31152918;31200655;34272776;36028842",
        "class_list": "",
        "function": "BHLHA9 duplication causing split hand/foot malformation with long bone deficiency. Review article Publication Status: Online-Only, [RefSeq, PubMed]; BHLHA9 gene contribute to the phenotype of small 17p13.3 chromosomal duplication in Miller-Dieker syndrome Publication Status: Online-Only, [RefSeq, PubMed]; Genomic duplications encompassing BHLHA9 are associated with SHFLD and non-Mendelian inheritance characterised by a high degree of non-penetrance with sex bias., [RefSeq, PubMed]; SHFLD3 phenotypes caused by 17p13.3 triplication/ duplication encompassing Fingerin (BHLHA9) invariably. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the basic helix-loop-helix family. The encoded protein is a transcription factor involved in limb development. Mutations in this gene have been associated with mesoaxial synostotic syndactyly Malik-Percin type (MSSD). Copy number variation of a locus containing this gene has been linked to a form of split-hand/foot malformation with long bone deficiency (SHFLD3). [provided by RefSeq, Mar 2015]., [RefSeq]; This is the second report providing evidence of association of polydactyly with Mesoaxial synostotic syndactyly caused by frameshift variant in the gene BHLHA9. The present molecular investigation will support genetic counselling of the local population carrying diseased variants., [RefSeq, PubMed]; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis., [UniProtKB, PubMed, PubMed]; Whole exome sequencing identified a novel frameshift variant in the BHLHA9 in an Iranian family with mesoaxial synostotic syndactyly., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MSH6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032502 developmental process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q7RTU4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86UB2-1",
        "uniprot_id": "BIVM_HUMAN",
        "mass": 56774.0,
        "length": 503,
        "protein_name": "Basic immunoglobulin-like variable motif-containing protein",
        "gene_name": "BIVM",
        "organism": "Human",
        "refseq_name": "basic immunoglobulin-like variable motif-containing protein isoform b",
        "refseq_ac": "NP_001153068",
        "gene_names_uniprotkb": "BIVM",
        "gene_names_refseq": "BIVM",
        "protein_names_uniprotkb": "Basic immunoglobulin-like variable motif-containing protein",
        "protein_names_refseq": "basic immunoglobulin-like variable motif-containing protein isoform b; basic immunoglobulin-like variable motif-containing protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54841)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;12036287;19773279;28832583;29242379;31844290;33912179;35051231;36757497",
        "class_list": "",
        "function": "Identification of genetic susceptibility in preterm newborns with bronchopulmonary dysplasia by whole-exome sequencing: BIVM gene may play a role., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
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        "reported_snv": 4,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2M1J2;Q9NXM4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004520 DNA endonuclease activity;GO:0003697 single-stranded DNA binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q86UB2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86UU0-1",
        "uniprot_id": "BCL9L_HUMAN",
        "mass": 157129.0,
        "length": 1499,
        "protein_name": "B-cell CLL/lymphoma 9-like protein",
        "gene_name": "BCL9L",
        "organism": "Human",
        "refseq_name": "B-cell CLL/lymphoma 9-like protein isoform a",
        "refseq_ac": "NP_872363",
        "gene_names_uniprotkb": "BCL9L; DLNB11",
        "gene_names_refseq": "B9L; BCL9-2; BCL9L; DLNB11",
        "protein_names_uniprotkb": "B-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; BCL9-like protein; Protein BCL9-2",
        "protein_names_refseq": "B cell CLL/lymphoma 9 like; B-cell CLL/lymphoma 9-like protein isoform a; B-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; BCL9-like protein; nuclear co-factor of beta-catenin signalling; protein BCL9-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283149);  (R-HSA-201722);  (R-HSA-3769402)",
        "pathway_count": 3,
        "publication_count": 154,
        "publication_id_list": "10.1074/mcp.M114.046862;10080941;10485845;10549281;10769018;10775268;10831834;10898789;10921920;10944533;11050151;11080158;11136974;11237011;11532957;11691915;11713476;11934263;11955446;11973335;11988739;12163411;12408824;12408825;12712206;12964048;14600025;14685266;14695187;15060161;15121853;15132997;15294866;15327769;15371335;15525529;15768032;15829968;16005293;16169192;16510874;16630820;16756492;16964243;17052462;17081983;17113272;17129358;17218525;17309600;17412698;17425782;17428831;17458864;17698607;17875931;18077418;18160704;18220336;18347063;18378692;18404694;18456656;18498752;18573912;18598779;18669648;18767875;18819930;19047045;19148484;19364920;19413330;19460168;19487454;19493659;19571879;19590513;19608861;19651622;19664994;19664995;19928349;19940019;20058876;20068231;21406692;21654818;21726809;22186018;22190459;22304967;22617422;22982193;23186163;24275569;24291232;24715725;25576301;25645385;25813380;27846572;28832583;29242379;29351928;29393594;29557506;30059200;30192525;30418433;30698996;31217245;31492838;31844290;32157095;32245944;32357974;32387766;32488085;32938750;32983136;33537174;33592498;33767438;33968037;33981976;34019948;34087483;34319913;34357683;34545187;35051231;35132862;35254053;35318648;35513511;35580925;35628130;36010968;36241641;37074911;38253038;38665916;39531497;39534244;8756721;8757136;8955148;9118222;9488439;9490669;9751710;9819412;9843967",
        "class_list": "",
        "function": "BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer., [RefSeq, PubMed]; Crystallographic analysis of how beta-catenin, BCL9, BCL9-2 and Tcf4 interact, [RefSeq, PubMed]; Dual-luciferase reporter confirmed that BCL9L is the target gene of both miR-22 and miR-214., [RefSeq, PubMed]; The interactions of Bcl9/Bcl9L with beta-catenin and Pygopus promote breast cancer growth, invasion, and metastasis., [RefSeq, PubMed]; Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity)., [UniProtKB]; Type I collagen promotes tumor progression of integrin beta1 positive gastric cancer through a BCL9L/beta-catenin signaling pathway., [RefSeq, PubMed]; Wnt/beta-Catenin Signalling and Its Cofactor BCL9L Have an Oncogenic Effect in Bladder Cancer Cells. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 13,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 13,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 13,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 42,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 64,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 0,
        "glyco_site_count": 18,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A4C1;Q67FY1;Q6ZWJ0;Q6ZWK2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008013 beta-catenin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:1990907 beta-catenin-TCF complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060070 canonical Wnt signaling pathway;GO:0022604 regulation of cell morphogenesis;GO:0010718 positive regulation of epithelial to mesenchymal transition",
        "synthesized_glycan_count": 0,
        "hit_score": 17.6,
        "record_id": "Q86UU0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IYS8-1",
        "uniprot_id": "BD1L2_HUMAN",
        "mass": 18075.0,
        "length": 172,
        "protein_name": "Biorientation of chromosomes in cell division protein 1-like 2",
        "gene_name": "BOD1L2",
        "organism": "Human",
        "refseq_name": "biorientation of chromosomes in cell division protein 1-like 2",
        "refseq_ac": "NP_001244893",
        "gene_names_uniprotkb": "BOD1L2; BOD1P; FAM44C",
        "gene_names_refseq": "BOD1L2; BOD1P; FAM44C",
        "protein_names_uniprotkb": "Biorientation of chromosomes in cell division protein 1-like 2; Biorientation of chromosomes in cell division protein 1 pseudogene; Protein FAM44C",
        "protein_names_refseq": "biorientation of chromosomes in cell division 1 pseudogene; biorientation of chromosomes in cell division protein 1-like 2; family with sequence similarity 44, member C; putative biorientation of chromosomes in cell division protein 1 pseudogene; putative biorientation of chromosomes in cell division protein 1-like 2; putative protein FAM44C",
        "tax_id": 9606,
        "disease": "intellectual disability (Disease Ontology:DOID:1059)",
        "pathway": " (hsa:284257)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "23481700;29437277;35051231",
        "class_list": "",
        "function": "May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
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        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KXU4;Q8WW13",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005813 centrosome;GO:0000776 kinetochore",
        "go_biological_process": "GO:0051301 cell division",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q8IYS8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N1M1-2",
        "uniprot_id": "BEST3_HUMAN",
        "mass": 76107.0,
        "length": 668,
        "protein_name": "Bestrophin-3",
        "gene_name": "BEST3",
        "organism": "Human",
        "refseq_name": "bestrophin-3 isoform 3",
        "refseq_ac": "NP_001269542",
        "gene_names_uniprotkb": "BEST3; VMD2L3",
        "gene_names_refseq": "BEST3; VMD2L3",
        "protein_names_uniprotkb": "Bestrophin-3; Vitelliform macular dystrophy 2-like protein 3",
        "protein_names_refseq": "bestrophin-3 isoform 3; vitelliform macular dystrophy 2-like 3; vitelliform macular dystrophy 2-like protein 3",
        "tax_id": 9606,
        "disease": "aortic dissection (Disease Ontology:DOID:0080685)",
        "pathway": " (hsa:144453);  (R-HSA-2672351)",
        "pathway_count": 2,
        "publication_count": 98,
        "publication_id_list": "10564087;10642508;10720933;10767424;10830164;10831588;11182090;11588175;11687798;11734858;11842292;11904445;11956057;12032738;12393854;12907679;1379744;14584882;14634667;15010458;15044642;15147738;15318163;15504734;15505377;15916532;15919655;16219661;16813530;16849430;16850186;17381423;17442670;17448995;17699613;17881003;18000046;18063579;18310267;18400985;18449189;18508966;18662336;18724360;19153159;19237432;19307298;19380724;19387438;19620632;19808995;19953639;20388639;20466723;20525693;20538786;21040849;21527911;21984732;22002868;22773952;22946059;2298749;23112050;2321095;23616951;24715725;25329324;2536303;26359375;26562072;26992070;28071645;28154142;28790369;29508533;30849546;31154438;32502341;34087483;34185709;7588753;7665160;7795595;8041726;8112288;8383669;8533761;8544406;8626462;8809036;9037075;9395096;9571199;9662395;9700209;9719863;9744806",
        "class_list": "",
        "function": "BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]., [RefSeq]; Identified three novel VMD2-related human genes demonstrating a high degree of conservation in their respective RFP-TM domains [VMD2L1, VMD2L2, VMD2L3], [RefSeq, PubMed]; Ligand-gated anion channel that allows the movement of chloride monoatomic anions across cell membranes when activated by calcium (Ca2+)., [UniProtKB, PubMed]; Results demonstrated that Best-3 is an endogenous inhibitor of NF-kappaB signaling pathway in endothelial cells, suggesting that forced Best-3 expression may be a novel approach for the treatment of vascular inflammatory diseases. Publication Status: Online-Only, [RefSeq, PubMed]; Results provide evidence that the bestrophins are expressed in pancreatic duct cells and, more specifically, that hBest1 plays a role in the calcium activated chloride channels found in these cells., [RefSeq, PubMed]; These results suggest that an auto-inhibitory mechanism in C termini of bestrophin 3 may be universal among bestrophins investigated in the study., [RefSeq, PubMed]; Whole-exome sequencing implicates a rare non-synonymous single-nucleotide variants of BEST3 as a candidate for mandibular prognathism in the Japanese pedigree., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MDI8;F8VVZ2;Q53YQ7;Q8N356;Q8NFT9;Q9BR80",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity;GO:0099095 ligand-gated monoatomic anion channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0034707 chloride channel complex",
        "go_biological_process": "GO:1902476 chloride transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 9.9,
        "record_id": "Q8N1M1-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NBU5-1",
        "uniprot_id": "ATAD1_HUMAN",
        "mass": 40744.0,
        "length": 361,
        "protein_name": "Outer mitochondrial transmembrane helix translocase",
        "gene_name": "ATAD1",
        "organism": "Human",
        "refseq_name": "outer mitochondrial transmembrane helix translocase isoform 1",
        "refseq_ac": "NP_001308896",
        "gene_names_uniprotkb": "ATAD1; FNP001",
        "gene_names_refseq": "AFDC1; ATAD1; FNP001; HKPX4; Msp1; THORASE; hATAD1",
        "protein_names_uniprotkb": "Outer mitochondrial transmembrane helix translocase; 7.4.2.-; ATPase family AAA domain-containing protein 1; Thorase; hATAD1",
        "protein_names_refseq": "ATPase family AAA domain-containing protein 1; outer mitochondrial transmembrane helix translocase isoform 1; outer mitochondrial transmembrane helix translocase",
        "tax_id": 9606,
        "disease": "hyperekplexia 4 (Disease Ontology:DOID:0080581)",
        "pathway": " (hsa:84896);  (R-HSA-9603798)",
        "pathway_count": 2,
        "publication_count": 111,
        "publication_id_list": "10.1101/2023.09.13.557529;10430017;10704444;11237011;11390669;11402059;11453642;11590176;11883941;12751901;12924628;14709540;15007061;15713480;15781447;16280322;16385451;16791427;16895967;16959974;16980692;17069900;17081983;18174172;18669648;18782765;19413330;20166139;20531392;20554521;20877624;21102411;21654843;22624858;22898188;23301498;23460677;23481700;23628762;24029068;24715725;24843043;25062251;25418920;25517356;25576301;25645385;25802875;26154972;26777132;26992070;27452731;27600516;28180185;28228285;28281558;28325759;28832583;28904123;29242379;29390050;29437277;29493099;29557506;29659736;29786170;30315122;30410026;30429286;30484775;31154438;31217245;31530632;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;33298915;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34357683;34509645;34561969;34932366;35051231;35251023;35318648;35505304;35580925;36010968;36215666;36241641;36284347;36409067;36933275;37789674;37938771;39024102;9418908",
        "class_list": "",
        "function": "ATAD1 inhibits hepatitis C virus infection by removing the viral TA-protein NS5B from mitochondria., [RefSeq, PubMed]; ATAD1 prevents clogging of TOM and damage caused by un-imported mitochondrial proteins., [RefSeq, PubMed]; CircRNA circ-ATAD1 suppresses miR-618 maturation to participate in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; Neonatal Hypertonia and Progressive Respiratory Failure due to Novel Heterozygous Mutation in ATAD1., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24843043). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DR26;Q6DKG1;Q6P4B9;Q8N3G1;Q8WYR9;Q969Y3",
        "ec_number_list": "3.1.2.-;7.6.2.-;2.3.2.27;2.3.2.36;7.4.2.-",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140567 membrane protein dislocase activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0005829 cytosol",
        "go_biological_process": "GO:0007612 learning;GO:0007613 memory;GO:0051967 negative regulation of synaptic transmission, glutamatergic;GO:0002092 positive regulation of receptor internalization;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "Q8NBU5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NDB2-1",
        "uniprot_id": "BANK1_HUMAN",
        "mass": 89282.0,
        "length": 785,
        "protein_name": "B-cell scaffold protein with ankyrin repeats",
        "gene_name": "BANK1",
        "organism": "Human",
        "refseq_name": "B-cell scaffold protein with ankyrin repeats isoform 2",
        "refseq_ac": "NP_001077376",
        "gene_names_uniprotkb": "BANK1",
        "gene_names_refseq": "BANK1; BANK",
        "protein_names_uniprotkb": "B-cell scaffold protein with ankyrin repeats",
        "protein_names_refseq": "B-cell scaffold protein with ankyrin repeats isoform 2; B-cell scaffold protein with ankyrin repeats",
        "tax_id": 9606,
        "disease": "diffuse scleroderma (Disease Ontology:DOID:1580); systemic scleroderma (Disease Ontology:DOID:418); autoimmune thyroiditis (Disease Ontology:DOID:7188); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:55024)",
        "pathway_count": 1,
        "publication_count": 45,
        "publication_id_list": "11782428;18204447;19110536;19180476;23481700;23555801;25418920;26154972;26992070;28228285;28832583;28834231;29242379;29314611;29393594;29557506;29632711;29786170;29789417;30315122;30524438;31154438;31530632;31844290;31848261;32157095;32357974;32502341;32983136;33091337;33298915;33815360;33912179;33968037;34066164;34127828;34171305;34357683;34561969;35051231;35580925;35930382;36054934;36241641;37938771",
        "class_list": "",
        "function": "Connection of BANK1, Tolerance, Regulatory B cells, and Apoptosis: Perspectives of a Reductionist Investigation. Publication Status: Online-Only, [RefSeq, PubMed]; Functional variants in the B-cell gene BANK1 are assoicated with systemic lupus erythematosus. GeneRIF: Genome-wide association study of gene-disease association. (HuGE Navigator) Erratum:[Nat Genet. 2008 Apr;40(4):484. Barrizzone, Nadia [corrected to Barizzone, Nadia]], [RefSeq, PubMed]; IKBKE and BANK1 Polymorphisms and Clinical Characteristics in Chinese Women with Systemic Lupus Erythematosus., [RefSeq, PubMed]; Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2., [UniProtKB, PubMed]; Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The Role of BANK1 in B Cell Signaling and Disease. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]., [RefSeq]; These results suggest that BANK1 SNPs and haplotypes may contribute to rheumatoid arthritis susceptibility with a low risk. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Variants in BANK1 are associated with lupus nephritis of European ancestry., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7W8;B0F3S2;Q8N5K8;Q8NB56;Q8WYN5;Q9NWP2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0035591 signaling adaptor activity;GO:0043274 phospholipase binding;GO:1990782 protein tyrosine kinase binding",
        "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0042113 B cell activation;GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation;GO:0050853 B cell receptor signaling pathway;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0050869 negative regulation of B cell activation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "Q8NDB2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TAM1-1",
        "uniprot_id": "BBS10_HUMAN",
        "mass": 80838.0,
        "length": 723,
        "protein_name": "BBSome complex assembly protein BBS10",
        "gene_name": "BBS10",
        "organism": "Human",
        "refseq_name": "BBSome complex assembly protein BBS10",
        "refseq_ac": "NP_078961",
        "gene_names_uniprotkb": "BBS10; C12orf58",
        "gene_names_refseq": "BBS10; C12orf58",
        "protein_names_uniprotkb": "BBSome complex assembly protein BBS10; Bardet-Biedl syndrome 10 protein",
        "protein_names_refseq": "BBSome complex assembly protein BBS10; bardet-Biedl syndrome 10 protein",
        "tax_id": 9606,
        "disease": "Bardet-Biedl syndrome 10 (Disease Ontology:DOID:0110132); Bardet-Biedl syndrome (Disease Ontology:DOID:1935)",
        "pathway": " (hsa:79738);  (R-HSA-5620922)",
        "pathway_count": 2,
        "publication_count": 56,
        "publication_id_list": "11252952;15258860;15314642;16582908;16823392;17101080;17574030;19081074;19190184;19421068;19575670;20080638;20120035;20233871;20603001;21344540;21427764;22072986;22139371;22389062;22500027;23219996;23351793;24296415;24714562;24715725;25443296;25446516;25576301;26992070;27397612;27846572;27862975;28254787;28808579;28904123;29557506;30429286;31844290;32157095;32387766;32897882;32938616;33630762;33912179;33968037;33981976;34171305;34509645;34940782;35051231;35561310;35580925;36010968;36012682;37938771",
        "class_list": "",
        "function": "Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons., [RefSeq, PubMed]; Comparative Natural History of Visual Function From Patients With Biallelic Variants in BBS1 and BBS10., [RefSeq, PubMed]; Detected in a family with high consanguinity and Bardet-Biedl syndrome., [RefSeq, PubMed]; Multi-Omics Studies Unveil Extraciliary Functions of BBS10 and Show Metabolic Aberrations Underlying Renal Disease in Bardet-Biedl Syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (PubMed:20080638). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). Involved in adipogenic differentiation (PubMed:19190184)., [UniProtKB, PubMed, PubMed]; This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and cognitive disability. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10. [provided by RefSeq, Jan 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96CW2;Q9H5D2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005929 cilium",
        "go_biological_process": "GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:1905515 non-motile cilium assembly;GO:0043254 regulation of protein-containing complex assembly;GO:0051131 chaperone-mediated protein complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q8TAM1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TD16-1",
        "uniprot_id": "BICD2_HUMAN",
        "mass": 93533.0,
        "length": 824,
        "protein_name": "Protein bicaudal D homolog 2",
        "gene_name": "BICD2",
        "organism": "Human",
        "refseq_name": "protein bicaudal D homolog 2 isoform 1",
        "refseq_ac": "NP_001003800",
        "gene_names_uniprotkb": "BICD2; KIAA0699",
        "gene_names_refseq": "BICD2; SMALED2A; SMALED2B; SMALED2; bA526D8.1",
        "protein_names_uniprotkb": "Protein bicaudal D homolog 2; Bic-D 2",
        "protein_names_refseq": "bic-D 2; bicaudal D homolog 2; coiled-coil protein BICD2; cytoskeleton-like bicaudal D protein homolog 2; homolog of Drosophila bicaudal D; protein bicaudal D homolog 2 isoform 1; protein bicaudal D homolog 2",
        "tax_id": 9606,
        "disease": "spinal muscular atrophy with lower extremity predominant 2A (Disease Ontology:DOID:0070349); spinal muscular atrophy with lower extremity predominant 2B (Disease Ontology:DOID:0070350)",
        "pathway": " (hsa:23299);  (R-HSA-6811436)",
        "pathway_count": 2,
        "publication_count": 126,
        "publication_id_list": "10359595;10559986;10562278;11080672;11483508;11864968;12401177;12432908;12447383;12925777;15144186;15483056;15914536;16207721;16314391;17081983;17322306;17488286;17827179;18212344;18641641;18664496;18669648;18691976;18767875;19413330;19635840;19651622;19664995;19753100;20068231;20386726;20420828;21173190;21406692;22130221;22562055;23186163;23333653;23481700;23664116;23664119;23664120;23783758;24275569;24482476;24714562;24715725;24891604;25233431;25453831;25512093;25576301;25814576;25892735;25962623;26154972;26375851;26728094;26811146;26992070;27600516;27751653;27846572;27862975;27920218;28228285;28514659;28635954;28832583;28834231;28904123;29242379;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30054298;30315122;30429286;30484775;31092671;31217245;31324691;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33537174;33592498;33717175;33912179;33968037;33981976;34087483;34185709;34357683;34509645;34561969;35051231;35561310;35580925;36010968;36150379;36241641;36284347;36930595;37047781;37217939;37938771;38526325;38719748;9030515;9050864;9671731;9733780",
        "class_list": "",
        "function": "Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; In vitro characterization of the full-length human dynein-1 cargo adaptor BicD2., [RefSeq, PubMed]; Isolation, cloning, and characterization of human Nek8, a new mammalian NIMA-related kinase, and its candidate substrate Bicd2, [RefSeq, PubMed]; M6Am methyltransferase PCIF1 negatively regulates ciliation by inhibiting BICD2 expression., [RefSeq, PubMed]; Microscopic and Biochemical Hallmarks of BICD2-Associated Muscle Pathology toward the Evaluation of Novel Variants. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular mechanism for recognition of the cargo adapter Rab6[GTP] by the dynein adapter BicD2. Publication Status: Online-Only, [RefSeq, PubMed]; Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 27,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75181;Q5TBQ2;Q5TBQ3;Q96LH2;Q9BT84;Q9H561",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008093 cytoskeletal anchor activity;GO:0031267 small GTPase binding;GO:0070840 dynein complex binding;GO:0034452 dynactin binding;GO:0051959 dynein light intermediate chain binding",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome",
        "go_biological_process": "GO:0015031 protein transport;GO:0007018 microtubule-based movement;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0034067 protein localization to Golgi apparatus;GO:0051642 centrosome localization",
        "synthesized_glycan_count": 0,
        "hit_score": 12.9,
        "record_id": "Q8TD16-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92858-1",
        "uniprot_id": "ATOH1_HUMAN",
        "mass": 38160.0,
        "length": 354,
        "protein_name": "Transcription factor ATOH1",
        "gene_name": "ATOH1",
        "organism": "Human",
        "refseq_name": "transcription factor ATOH1",
        "refseq_ac": "NP_005163",
        "gene_names_uniprotkb": "ATOH1; ATH1; BHLHA14",
        "gene_names_refseq": "ATH1; ATOH1; DFNA89; HATH1; MATH-1; bHLHa14",
        "protein_names_uniprotkb": "Transcription factor ATOH1; Atonal bHLH transcription factor 1; Class A basic helix-loop-helix protein 14; Helix-loop-helix protein hATH-1; Protein atonal homolog 1; bHLHa14; hATH1",
        "protein_names_refseq": "atonal homolog bHLH transcription factor 1; basic helix-loop-helix family member a14; class A basic helix-loop-helix protein 14; helix-loop-helix protein hATH-1; protein atonal homolog 1; transcription factor ATOH1",
        "tax_id": 9606,
        "disease": "autosomal dominant nonsyndromic deafness 89 (Disease Ontology:DOID:0070612)",
        "pathway": " (hsa:474)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11889557;12209986;28832583;29168692;33111345;33275808;33968037;34185709;34582650;35246011;37943051;8872459",
        "class_list": "",
        "function": "Intestinal phenotype is maintained by Atoh1 in the cancer region of intraductal papillary mucinous neoplasm., [RefSeq, PubMed]; LGR5, HES1 and ATOH1 in Young Rectal Cancer Patients in Egyptian. Publication Status: Online-Only, [RefSeq, PubMed]; Maps to 10q21-22.  Candidate gene for optic nerve aplasia and related syndromes., [RefSeq, PubMed]; Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma Erratum:[Int J Cancer. 2004 Dec 20;112(6):1086], [RefSeq, PubMed]; S-100 and MATH-1 Protein Expressions Can Be Useful for the Prediction of Clinical Outcome in Neuroblastoma Patients., [RefSeq, PubMed]; Small activating RNA activation of ATOH1 promotes regeneration of human inner ear hair cells., [RefSeq, PubMed]; Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene ATOH1., [RefSeq, PubMed]; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14CT9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031490 chromatin DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0014014 negative regulation of gliogenesis;GO:0045666 positive regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0006366 transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q92858-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96L58-1",
        "uniprot_id": "B3GT6_HUMAN",
        "mass": 37138.0,
        "length": 329,
        "protein_name": "Beta-1,3-galactosyltransferase 6",
        "gene_name": "B3GALT6",
        "organism": "Human",
        "refseq_name": "beta-1,3-galactosyltransferase 6 precursor",
        "refseq_ac": "NP_542172",
        "gene_names_uniprotkb": "B3GALT6",
        "gene_names_refseq": "ALGAZ; B3GALT6; EDSP2; EDSSPD2; SEMDJL1; beta3GalT6",
        "protein_names_uniprotkb": "Beta-1,3-galactosyltransferase 6; 2.4.1.134; Beta-1,3-GalTase 6; Beta3Gal-T6; Beta3GalT6; GAG GalTII; Galactosyltransferase II; Galactosylxylosylprotein 3-beta-galactosyltransferase; UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6",
        "protein_names_refseq": "GAG GalTII; UDP-Gal:betaGal beta 1,3-galactosyltransferase 6; UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6; UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 6; beta-1,3-GalTase 6; beta-1,3-galactosyltransferase 6 precursor; beta3Gal-T6; galactosyltransferase II; galactosylxylosylprotein 3-beta-galactosyltransferase",
        "tax_id": 9606,
        "disease": "Ehlers-Danlos syndrome spondylodysplastic type 2 (Disease Ontology:DOID:0050802); spondyloepimetaphyseal dysplasia with joint laxity (Disease Ontology:DOID:0112197); spondyloepimetaphyseal dysplasia with joint laxity type 1 (Disease Ontology:DOID:0112198); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); Al-Gazali syndrome (MONDO:MONDO:0012282); obsolete spondyloepimetaphyseal dysplasia, Pakistani type (MONDO:MONDO:0013019)",
        "pathway": " (hsa:126792);  (R-HSA-1971475);  (R-HSA-4420332)",
        "pathway_count": 3,
        "publication_count": 60,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10319196;10473568;10506123;10842173;11099377;11551958;11877387;12522689;14993226;15294915;15461586;17194707;19473117;19913121;20628086;22810237;23584533;23656592;23664117;23664118;24425863;24766538;25149931;25521717;27023906;28467828;28649518;29443383;29557506;29620724;29741879;29931299;30573663;30779550;31092671;31154438;31614862;31844290;32161166;32350084;32387766;32517548;32983136;33592498;33631843;33691108;33912179;33981976;34159694;34171305;34357683;35051231;36581221;37074911;38065100;38665916;9506957;9892646",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease., [RefSeq, PubMed]; B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling., [RefSeq, PubMed]; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues., [UniProtKB, PubMed, PubMed, PubMed]; Broadening the phenotypic spectrum of Beta3GalT6-associated phenotypes., [RefSeq, PubMed]; Defineed some of the clinical features of B4GALT7 and B3GALT6-related conditions and underlined the extreme hypermobility of distal joints and the soft, doughy skin on the hands and feet as features that may be useful as the first clues for a correct diagnosis. Publication Status: Online-Only, [RefSeq, PubMed]; Keratoconus in a patient with B3GALT6-related disorder., [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The enzyme encoded by this intronless gene is a beta-1,3-galactosyltransferase found in the medial Golgi apparatus, where it catalyzes the transfer of galactose from UDP-galactose to substrates containing a terminal beta-linked galactose moiety. The encoded enzyme has a particular affinity for galactose-beta-1,4-xylose found in the linker region of glycosamines. This enzyme is required for glycosaminoglycan synthesis. [provided by RefSeq, Jun 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 581,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 6,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T7M5",
        "ec_number_list": "2.4.1.134",
        "go_molecular_function": "GO:0035250 UDP-galactosyltransferase activity;GO:0047220 galactosylxylosylprotein 3-beta-galactosyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane;GO:0005797 Golgi medial cisterna",
        "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0050651 dermatan sulfate proteoglycan biosynthetic process;GO:0030166 proteoglycan biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q96L58-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9C0J9-1",
        "uniprot_id": "BHE41_HUMAN",
        "mass": 50498.0,
        "length": 482,
        "protein_name": "Class E basic helix-loop-helix protein 41",
        "gene_name": "BHLHE41",
        "organism": "Human",
        "refseq_name": "class E basic helix-loop-helix protein 41",
        "refseq_ac": "NP_110389",
        "gene_names_uniprotkb": "BHLHE41; BHLHB3; DEC2; SHARP1",
        "gene_names_refseq": "BHLHB3; BHLHE41; DEC2; FNSS1; SHARP1; hDEC2",
        "protein_names_uniprotkb": "Class E basic helix-loop-helix protein 41; Class B basic helix-loop-helix protein 3; Differentially expressed in chondrocytes protein 2; Enhancer-of-split and hairy-related protein 1; SHARP-1; bHLHb3; bHLHe41; hDEC2",
        "protein_names_refseq": "basic helix-loop-helix domain containing, class B, 3; class E basic helix-loop-helix protein 41; differentially expressed in chondrocytes protein 2; enhancer-of-split and hairy-related protein 1",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); lung adenocarcinoma (Disease Ontology:DOID:3910); esophageal cancer (Disease Ontology:DOID:5041); obsolete short sleep, familial natural, 1 (MONDO:MONDO:0020784)",
        "pathway": " (hsa:79365);  (R-HSA-1368108)",
        "pathway_count": 2,
        "publication_count": 66,
        "publication_id_list": "11018023;11162494;11241162;11278948;12130638;12354771;12397359;12406875;12738229;14672706;15193144;15500444;15560782;16857194;17194498;18411297;18587630;19679812;19710929;19786558;24714562;24715725;25083013;25576301;25755297;26992070;27600516;27846572;27862975;27920218;28832583;28904123;29242379;29493099;29557506;29786170;2991279;30429286;31154438;31530632;31844290;31848261;32157095;32350084;32897882;32938616;32983136;33298915;33592498;33912179;33968037;34405274;34638690;34768959;35051231;35251023;35318648;35580925;36010968;36284347;37511489;37938771;38448474;38847478;7981125;8618898",
        "class_list": "",
        "function": "Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development. Review article Publication Status: Online-Only, [RefSeq, PubMed]; BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer's disease and other disorders of lipid-rich tissues. Publication Status: Online-Only, [RefSeq, PubMed]; BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; DEC1 and DEC2 may play a crucial role in the adaptation to hypoxia, [RefSeq, PubMed]; Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family. [dec1], [RefSeq, PubMed]; High expression of DEC2 distinguishes chondroblastic osteosarcoma and promotes tumour growth by activating the VEGFC/VEGFR2 signalling pathway., [RefSeq, PubMed]; The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, Feb 2014]., [RefSeq]; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:11278948, PubMed:14672706, PubMed:15193144, PubMed:15560782, PubMed:18411297, PubMed:19786558, PubMed:25083013). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:25083013). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2I2N8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0009952 anterior/posterior pattern specification;GO:0010944 negative regulation of transcription by competitive promoter binding",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "Q9C0J9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZW61-1",
        "uniprot_id": "BBS12_HUMAN",
        "mass": 79085.0,
        "length": 710,
        "protein_name": "Chaperonin-containing T-complex member BBS12",
        "gene_name": "BBS12",
        "organism": "Human",
        "refseq_name": "chaperonin-containing T-complex member BBS12",
        "refseq_ac": "NP_001171478",
        "gene_names_uniprotkb": "BBS12; C4orf24",
        "gene_names_refseq": "BBS12; C4orf24",
        "protein_names_uniprotkb": "Chaperonin-containing T-complex member BBS12; Bardet-Biedl syndrome 12 protein",
        "protein_names_refseq": "chaperonin-containing T-complex member BBS12",
        "tax_id": 9606,
        "disease": "Bardet-Biedl syndrome 12 (Disease Ontology:DOID:0110134)",
        "pathway": " (hsa:166379);  (R-HSA-5620922)",
        "pathway_count": 2,
        "publication_count": 42,
        "publication_id_list": "11237011;11252952;15258860;15314642;17160889;17574030;19081074;19190184;19421068;19575670;20080638;20120035;20233871;20603001;21344540;21427764;22072986;22139371;22389062;22500027;23351793;24296415;25443296;25446516;26900326;28904123;29557506;31844290;32157095;32387766;32938616;32983136;33141586;33912179;33968037;33981976;34171305;34932366;35051231;35494241;35580925;37293956",
        "class_list": "",
        "function": "BBS12 accounts for approximately 5% of all BBS cases and defines a novel branch of the type II chaperonin superfamily, [RefSeq, PubMed]; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). Involved in adipogenic differentiation (PubMed:19190184)., [UniProtKB, PubMed, PubMed]; Exome sequencing in a Romanian Bardet-Biedl syndrome cohort revealed an overabundance of causal BBS12 variants., [RefSeq, PubMed]; The BBS10 and BBS12 proteins are located within the basal body of this primary cilium and inhibition of their expression impairs ciliogenesis, activates the GSK3 pathway, and induces PPAR nuclear accumulation, hence favoring adipogenesis, [RefSeq, PubMed]; The protein encoded by this gene is part of a complex that is involved in membrane trafficking. The encoded protein is a molecular chaperone that aids in protein folding upon ATP hydrolysis. This protein also plays a role in adipocyte differentiation. Defects in this gene are a cause of Bardet-Biedl syndrome type 12. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DNX5;Q7Z342;Q7Z482;Q8NAB8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005929 cilium",
        "go_biological_process": "GO:0045494 photoreceptor cell maintenance;GO:0045599 negative regulation of fat cell differentiation;GO:0051131 chaperone-mediated protein complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q6ZW61-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q03692-1",
        "uniprot_id": "COAA1_HUMAN",
        "mass": 66158.0,
        "length": 680,
        "protein_name": "Collagen alpha-1(X) chain",
        "gene_name": "COL10A1",
        "organism": "Human",
        "refseq_name": "collagen alpha-1(X) chain precursor",
        "refseq_ac": "NP_000484",
        "gene_names_uniprotkb": "COL10A1",
        "gene_names_refseq": "COL10A1",
        "protein_names_uniprotkb": "Collagen alpha-1(X) chain",
        "protein_names_refseq": "Schmid metaphyseal chondrodysplasia; collagen X, alpha-1 polypeptide; collagen alpha-1(X) chain precursor; collagen alpha-1(X) chain; collagen, type X, alpha 1",
        "tax_id": 9606,
        "disease": "Schmid metaphyseal chondrodysplasia (Disease Ontology:DOID:0080021); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); renovascular hypertension (Disease Ontology:DOID:1591); osteochondrodysplasia (Disease Ontology:DOID:2256); acute kidney failure (Disease Ontology:DOID:3021); lung adenocarcinoma (Disease Ontology:DOID:3910); brain edema (Disease Ontology:DOID:4724); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); degenerative disc disease (Disease Ontology:DOID:90)",
        "pathway": " (hsa:1300);  (R-HSA-1442490);  (R-HSA-1650814);  (R-HSA-2022090);  (R-HSA-216083);  (R-HSA-3000171);  (R-HSA-8948216)",
        "pathway_count": 7,
        "publication_count": 184,
        "publication_id_list": "10049780;10209034;10366422;10438935;10479448;10543983;10551873;10593924;10596943;10605720;10640428;10673366;10713152;10809722;10811134;10934207;10966814;10982388;10991694;11013208;11119712;11158588;11237011;11518510;11572855;11577169;11713259;11839302;11847221;11927537;11980922;12473679;12475640;12482924;12496264;12554676;12579531;12585966;12646579;12682293;12807887;1323838;1397333;1400327;14500733;14602708;15005656;15044469;15240572;15257288;15265795;15330449;15345499;15383545;15713743;1577494;15837520;1587271;15880705;1588291;15899827;15950618;16002701;16051604;16239428;16591531;16731529;16754661;16806867;16825197;16933105;1704217;17088321;171650;17339034;17403716;1743401;1764025;17968485;18487197;18622425;18710925;18775695;19075007;19502598;19693541;20033473;2005102;2010551;2037056;20470363;20705068;21593211;2169335;21878990;21935455;21967573;22241472;22382088;2253219;22539938;22884367;2307289;23374253;2537292;2543975;2548603;2551898;28218747;2834383;2845110;28832583;3038863;30654118;31217245;3173483;31844290;3223920;32387766;32938616;33912179;35051231;38147021;38253038;38780151;3905801;39198393;39247832;3938630;39392043;6258630;6270089;6307276;6694361;6809411;710450;7505120;7525578;7541634;7542249;7559467;7607655;7685013;7749409;7876225;7890717;7936797;8004099;8012364;8118028;8207089;8220429;8304336;8344274;8463259;8554571;8560266;8576151;8782043;8798654;8838667;8910476;8920930;8986632;8999957;9008168;9054364;9067753;9092507;9101290;9251239;9443892;9525992;9545296;9560306;9565552;9582318;9651395;9659899;9659900;9837818;9852679;9856810;9858236",
        "class_list": "glycogene",
        "function": "Experimental validation and pan-cancer analysis identified COL10A1 as a novel oncogene and potential therapeutic target in prostate cancer., [RefSeq, PubMed]; LncRNA HAGLROS promotes breast cancer evolution through miR-135b-3p/COL10A1 axis and exosome-mediated macrophage M2 polarization. Publication Status: Online-Only, [RefSeq, PubMed]; METTL16 Promotes Stability of SYNPO2L mRNA and leading to Cancer Cell Lung Metastasis by Secretion of COL10A1 and attract the Cancer-Associated Fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Oncogenic mechanisms of COL10A1 in cancer and clinical challenges (Review). Review article, [RefSeq, PubMed]; This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD). [provided by RefSeq, Jul 2008]., [RefSeq]; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage., [UniProtKB]; Upregulation of collagen type X alpha 1 promotes the progress of triple-negative breast cancer via Wnt/beta-catenin signaling., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1075,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 11,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4P2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005788 endoplasmic reticulum lumen;GO:0031012 extracellular matrix;GO:0005581 collagen trimer;GO:0005599 collagen type X trimer",
        "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0001501 skeletal system development",
        "synthesized_glycan_count": 0,
        "hit_score": 19.2,
        "record_id": "Q03692-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PF18-1",
        "uniprot_id": "MORN3_HUMAN",
        "mass": 27585.0,
        "length": 240,
        "protein_name": "MORN repeat-containing protein 3",
        "gene_name": "MORN3",
        "organism": "Human",
        "refseq_name": "MORN repeat-containing protein 3",
        "refseq_ac": "NP_776254",
        "gene_names_uniprotkb": "MORN3",
        "gene_names_refseq": "MORN3",
        "protein_names_uniprotkb": "MORN repeat-containing protein 3",
        "protein_names_refseq": "MORN repeat-containing protein 3; membrane occupation and recognition nexus repeat containing protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283385)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "29632711;29681526;33691108",
        "class_list": "",
        "function": "Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors (PubMed:29681526). May play a role in the regulation of spermatogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86YQ9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0001669 acrosomal vesicle",
        "go_biological_process": "GO:1901797 negative regulation of signal transduction by p53 class mediator",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q6PF18-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TEC5-1",
        "uniprot_id": "SH3R2_HUMAN",
        "mass": 79320.0,
        "length": 729,
        "protein_name": "E3 ubiquitin-protein ligase SH3RF2",
        "gene_name": "SH3RF2",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase SH3RF2 isoform X2",
        "refseq_ac": "XP_006714820",
        "gene_names_uniprotkb": "SH3RF2; POSH3; POSHER; PPP1R39; RNF158",
        "gene_names_refseq": "HEPP1; POSHER; PPP1R39; RNF158; SH3RF2",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SH3RF2; 2.3.2.27; HEPP1; Heart protein phosphatase 1-binding protein; POSH-eliminating RING protein; Protein phosphatase 1 regulatory subunit 39; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; SH3 domain-containing RING finger protein 2",
        "protein_names_refseq": "E3 ubiquitin-protein ligase SH3RF2 isoform X2",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)",
        "pathway": " (hsa:153769)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "19389623;19807924;19945436;20696164;22128169;24130170;29485866;29557506;30429286;30833945;32938616;33592498;33968037;34171305;35051231;35580925",
        "class_list": "",
        "function": "Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19389623, PubMed:19945436)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K961;Q08AM9;Q6GMR9;Q8N5S8;Q96LP8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0008157 protein phosphatase 1 binding;GO:0004864 protein phosphatase inhibitor activity;GO:0019902 phosphatase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0031397 negative regulation of protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q8TEC5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q2TAL6-1",
        "uniprot_id": "VWC2_HUMAN",
        "mass": 35282.0,
        "length": 325,
        "protein_name": "Brorin",
        "gene_name": "VWC2",
        "organism": "Human",
        "refseq_name": "brorin precursor",
        "refseq_ac": "NP_940972",
        "gene_names_uniprotkb": "VWC2; PRO1434",
        "gene_names_refseq": "PSST739; UNQ739; VWC2",
        "protein_names_uniprotkb": "Brorin; Brain-specific chordin-like protein; von Willebrand factor C domain-containing protein 2",
        "protein_names_refseq": "brain-specific chordin-like protein; brorin precursor; brorin; von Willebrand factor C domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:375567)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "12975309;17400546;29789417",
        "class_list": "",
        "function": "BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity)., [UniProtKB]; This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.[provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6UXE2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005615 extracellular space;GO:0032281 AMPA glutamate receptor complex;GO:0005604 basement membrane",
        "go_biological_process": "GO:0045666 positive regulation of neuron differentiation;GO:0030514 negative regulation of BMP signaling pathway;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q2TAL6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15156-1",
        "uniprot_id": "ZBT7B_HUMAN",
        "mass": 58027.0,
        "length": 539,
        "protein_name": "Zinc finger and BTB domain-containing protein 7B",
        "gene_name": "ZBTB7B",
        "organism": "Human",
        "refseq_name": "zinc finger and BTB domain-containing protein 7B isoform 2",
        "refseq_ac": "NP_001239335",
        "gene_names_uniprotkb": "ZBTB7B; ZBTB15; ZFP67; ZNF857B",
        "gene_names_refseq": "CKROX; THPOK; ZBTB15; ZBTB7B; ZFP-67; ZFP67; ZNF857B; c-KROX; hcKROX; vGAF",
        "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 7B; Krueppel-related zinc finger protein cKrox; T-helper-inducing POZ/Krueppel-like factor; Zfp-67; Zinc finger and BTB domain-containing protein 15; Zinc finger protein 67 homolog; Zinc finger protein 857B; Zinc finger protein Th-POK; hcKrox",
        "protein_names_refseq": "T-helper-inducing POZ/Krueppel-like factor; krueppel-related zinc finger protein cKrox; zinc finger and BTB domain containing 15; zinc finger and BTB domain-containing protein 7B isoform 2; zinc finger protein 67 homolog; zinc finger protein 857B; zinc finger protein Th-POK",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51043)",
        "pathway_count": 1,
        "publication_count": 45,
        "publication_id_list": "18669648;20220067;20810990;22706990;24275569;24715725;25576301;25645385;28228285;28832583;29242379;29786170;30429286;30524438;30779550;31154438;31222486;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33537174;33592498;33912179;33968037;33981976;34087483;34171305;34353698;34509645;35051231;35761286;35941174;36010968;36215666;36241641;36284347;39107297;9370309",
        "class_list": "",
        "function": "A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer., [RefSeq, PubMed]; ALDH1A1 promotes immune escape of tumor cells through ZBTB7B-glycolysis pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Epigenetic DNA methylation of Zbtb7b regulates the population of double-positive CD4(+)CD8(+) T cells in ulcerative colitis. Publication Status: Online-Only, [RefSeq, PubMed]; ThPOK transcriptionally inactivates TNFRSF12A to increase the proliferation of T cells with the involvement of the NF-kB pathway., [RefSeq, PubMed]; This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]., [RefSeq]; Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity)., [UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E3K5;D3DV83;J3KQQ3;Q68DR2;Q96EP2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0032740 positive regulation of interleukin-17 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0032868 response to insulin",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "O15156-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZNE5-1",
        "uniprot_id": "BAKOR_HUMAN",
        "mass": 55309.0,
        "length": 492,
        "protein_name": "Beclin 1-associated autophagy-related key regulator",
        "gene_name": "ATG14",
        "organism": "Human",
        "refseq_name": "beclin 1-associated autophagy-related key regulator",
        "refseq_ac": "NP_055739",
        "gene_names_uniprotkb": "ATG14; ATG14L; KIAA0831",
        "gene_names_refseq": "ATG14L; ATG14; BARKOR; KIAA0831",
        "protein_names_uniprotkb": "Beclin 1-associated autophagy-related key regulator; Atg14L; Autophagy-related protein 14-like protein; Barkor",
        "protein_names_refseq": "ATG14 autophagy related 14 homolog; Beclin 1-Interacting protein; autophagy-related protein 14-like protein; beclin 1-associated autophagy-related key regulator",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22863);  (R-HSA-1632852);  (R-HSA-9705671);  (R-HSA-983170);  (R-HSA-9920951)",
        "pathway_count": 5,
        "publication_count": 157,
        "publication_id_list": "10064069;10600378;10777614;10825291;10982397;11096062;11160214;11163199;11514579;11825910;12019269;12436109;12436110;12645939;12692549;12759408;14681859;14718384;15187094;15208624;15286279;15927284;16465444;16473882;16963840;17056546;17081983;17088086;17316621;17618624;17656363;18321988;18439900;18691976;18843052;19050071;19119025;19193869;19211835;19261456;19270696;19322194;19342655;19361863;19369195;19426129;19575639;19590496;19851281;19855179;19898463;20059746;2038058;20605430;20713597;20921139;21050182;21177865;21205641;21258367;21383122;21460621;21819378;22170151;22314358;22682742;22941947;23202584;23685627;23727157;23878393;23884233;23954414;2450918;24747438;24954904;24973451;25484072;25568151;25686604;26992070;27108190;28218432;28832583;30070610;30767700;31123703;31733992;31850239;32157095;32350084;32353859;32428392;32589897;32690950;32726803;32728199;32938616;32953130;32979938;33024073;33060197;33097660;33110251;33349665;33360543;33372174;33372854;33396605;33440148;33479219;33495715;33514628;33567255;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33963333;33989516;33990585;34021074;34054808;34084167;34110168;34166398;34239064;34290717;34341353;34357683;34375313;34400613;34439781;34452305;34471099;34502139;34597346;35051231;35102342;35580925;35643212;36310878;37043109;37051252;37632749;37741434;37915253;38665916;7628435;7642652;7876241;8342042;9605141",
        "class_list": "",
        "function": "ATG14 plays a critical role in hepatic lipid droplet homeostasis., [RefSeq, PubMed]; Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination., [RefSeq, PubMed]; KLF15 Transcriptionally Activates ATG14 to Promote Autophagy and Attenuate Damage of ox-LDL-Induced HAECs., [RefSeq, PubMed]; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604, PubMed:37632749). Modulates the hepatic lipid metabolism (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJE4;A8K9U5;B7ZWP5;O94920;Q32MK7;Q32MK8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0051020 GTPase binding;GO:0043495 protein-membrane adaptor activity;GO:0035014 phosphatidylinositol 3-kinase regulator activity;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity",
        "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0045335 phagocytic vesicle",
        "go_biological_process": "GO:0097352 autophagosome maturation;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0000045 autophagosome assembly;GO:0001934 positive regulation of protein phosphorylation;GO:0001933 negative regulation of protein phosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 16.0,
        "record_id": "Q6ZNE5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q53HL2-1",
        "uniprot_id": "BOREA_HUMAN",
        "mass": 31323.0,
        "length": 280,
        "protein_name": "Borealin",
        "gene_name": "CDCA8",
        "organism": "Human",
        "refseq_name": "borealin",
        "refseq_ac": "NP_001243804",
        "gene_names_uniprotkb": "CDCA8; PESCRG3",
        "gene_names_refseq": "BOREALIN; BOR; CDCA8; DasraB; MESRGP",
        "protein_names_uniprotkb": "Borealin; Cell division cycle-associated protein 8; Dasra-B; Pluripotent embryonic stem cell-related gene 3 protein; hDasra-B",
        "protein_names_refseq": "Dasra B; borealin; cell division cycle-associated protein 8; dasra-B; hDasra-B; pluripotent embryonic stem cell-related gene 3 protein",
        "tax_id": 9606,
        "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:55143);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-4615885);  (R-HSA-5663220);  (R-HSA-68877);  (R-HSA-9648025)",
        "pathway_count": 9,
        "publication_count": 191,
        "publication_id_list": "10411507;10600384;10678165;10759568;10862613;10958683;11081627;11181178;11371342;11509732;11535616;11709553;11804586;12006501;12149243;12188893;12194817;12429848;12577064;12679384;12732141;12805219;12832072;12852857;14730319;15006353;15085137;15249581;15260989;15339662;15507212;15561729;15723797;15737063;15864301;15866170;15931174;15944396;15989970;16239925;16291752;16292343;16427043;16436504;16439214;16541025;16547492;16565220;16571674;16622419;16622420;16682347;16890222;16943183;17030981;17112726;17113138;17129783;17183683;17196341;17198702;17241471;17287340;1737036;17483322;17956729;18001770;18097444;18212344;18243099;18381449;18394993;18591255;18669648;18691976;18716626;18923426;18946085;19007248;19350017;19369195;19413330;19530738;19596686;19651622;19664995;19690332;19691289;19696148;19815554;19965387;20030946;20058876;20068230;20068231;20101212;20591975;20663916;20739936;20803554;21111234;21148482;21167178;21397845;21406692;21554500;21576392;21868368;21878504;21987589;22094460;22275430;22457066;22464730;22608513;22790947;22885700;23186163;23222643;23481700;23801653;24714562;24715725;24782567;24914801;25114211;25218447;25418920;25576301;25740311;25789526;26154972;26375851;26728094;26992070;27058226;27846572;27920218;28004745;28063628;28228285;28649982;28832583;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29789417;30315122;31154438;31409757;31530632;31844290;31937595;31998317;32157095;32161166;32265295;32357974;32488085;32502341;32938616;33141586;33298915;33592498;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34260926;34357683;34509645;34561969;35318648;35561310;35580925;36010968;36855818;36898512;37428386;37813876;40307207;9649308;9649503;9892021",
        "class_list": "",
        "function": "A 1-kb human CDCA8 promoter directs the spermatogonia-specific luciferase expression in adult testis., [RefSeq, PubMed]; CDCA8 Facilitates Tumor Proliferation and Predicts a Poor Prognosis in Hepatocellular Carcinoma., [RefSeq, PubMed]; CDCA8 promotes bladder cancer survival by stabilizing HIF1alpha expression under hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]; Cell division cycle-associated 8 is a prognostic biomarker related to immune invasion in hepatocellular carcinoma., [RefSeq, PubMed]; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 35,
        "reported_mutagensis": 25,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DPT4;Q53HN1;Q96AM3;Q9NVW5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0051233 spindle midzone;GO:0015630 microtubule cytoskeleton",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0090307 mitotic spindle assembly;GO:0000281 mitotic cytokinesis;GO:0007080 mitotic metaphase chromosome alignment;GO:0051256 mitotic spindle midzone assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 19.4,
        "record_id": "Q53HL2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P18545-1",
        "uniprot_id": "CNRG_HUMAN",
        "mass": 9643.0,
        "length": 87,
        "protein_name": "Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma",
        "gene_name": "PDE6G",
        "organism": "Human",
        "refseq_name": "retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma",
        "refseq_ac": "NP_002593",
        "gene_names_uniprotkb": "PDE6G; PDEG",
        "gene_names_refseq": "PDE6G; PDEG; RP57",
        "protein_names_uniprotkb": "Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Rod GMP-PDE gamma",
        "protein_names_refseq": "GMP-PDE gamma; phosphodiesterase 6G, cGMP-specific, rod, gamma; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; rod cG-PDE G",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa 57 (Disease Ontology:DOID:0110407); retinitis pigmentosa (Disease Ontology:DOID:10584)",
        "pathway": " (hsa:5148);  (R-HSA-2485179);  (R-HSA-2514859);  (R-HSA-4086398)",
        "pathway_count": 4,
        "publication_count": 137,
        "publication_id_list": "10037746;10051575;10380924;10391246;10391247;10395542;10488343;10564809;10588714;10676965;10777564;10858654;11015615;11030334;11292825;11502744;11563835;11601986;11687658;11713293;11754336;12015605;12036349;12086864;12119397;12432397;12467591;12467592;12471263;12482967;12499365;12556497;12624098;12729560;12825937;12975316;1356371;1379636;1387789;1436039;14702087;14704854;14977528;15494017;15545263;15611108;15946941;1614872;16274222;16460277;16880514;16895762;16908407;16920709;17114291;1720239;1722240;17426020;17636946;17684012;18456304;18488142;18803695;19177143;19536106;1965799;19818506;19851316;1999465;20397626;20430952;20655036;20850105;20975703;20979602;21118996;2155175;2161380;21903638;22658984;22941947;23151663;23256519;23416699;23632248;23904219;2422346;2457685;2467600;2473195;2540796;2550422;2558719;2578616;26590425;2748346;2835761;2837463;2841328;28832583;29242379;29557506;3006923;3095147;3164688;3933561;4359491;4361997;4366891;4772407;6264430;6930647;7525588;7526403;7644482;7670478;7678445;7682292;7777544;7983048;8125719;8382952;8494894;8500562;8626439;8673138;8706659;8812493;8913594;9073455;9119368;9353336;9389482;9430683;9459445;9478004;9506952",
        "class_list": "",
        "function": "Collectively, we report previously unrecognized PDE6 expression in human lungs, significant alterations of the PDE6D and PDE6G/H subunits in IPF lungs. Erratum:[Respir Res. 2022 Jan 6;23(1):2. doi: 10.1186/s12931-021-01907-5. PMID: 34991577] Publication Status: Online-Only, [RefSeq, PubMed]; Inhibitory gamma subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits. Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification., [UniProtKB, UniProtKB]; The C-terminus of PED gamma occludes the active site of PDE6, thereby preventing hydrolysis of cGMP., [RefSeq, PubMed]; These findings demonstrate the positive role of the gamma subunit in maintaining phosphodiesterase activity and confirm the contribution of PDE6G to the etiology of retinitis pigmentosa in humans., [RefSeq, PubMed]; This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3KP63;Q7Z3U8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0030507 spectrin binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0097381 photoreceptor disc membrane;GO:0001750 photoreceptor outer segment;GO:0042622 photoreceptor outer segment membrane",
        "go_biological_process": "GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 13.8,
        "record_id": "P18545-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A2VCK2-1",
        "uniprot_id": "DCD2B_HUMAN",
        "mass": 37665.0,
        "length": 349,
        "protein_name": "Doublecortin domain-containing protein 2B",
        "gene_name": "DCDC2B",
        "organism": "Human",
        "refseq_name": "doublecortin domain-containing protein 2B",
        "refseq_ac": "NP_001092904",
        "gene_names_uniprotkb": "DCDC2B",
        "gene_names_refseq": "DCDC2B",
        "protein_names_uniprotkb": "Doublecortin domain-containing protein 2B",
        "protein_names_refseq": "doublecortin domain-containing protein 2B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:149069)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "29557506;31937595;35051231",
        "class_list": "",
        "function": "This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZBC6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005874 microtubule;GO:0005815 microtubule organizing center",
        "go_biological_process": "GO:0035556 intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "A2VCK2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09228-1",
        "uniprot_id": "CYTT_HUMAN",
        "mass": 16445.0,
        "length": 141,
        "protein_name": "Cystatin-SA",
        "gene_name": "CST2",
        "organism": "Human",
        "refseq_name": "cystatin-SA precursor",
        "refseq_ac": "NP_001313",
        "gene_names_uniprotkb": "CST2",
        "gene_names_refseq": "CST2",
        "protein_names_uniprotkb": "Cystatin-SA; Cystatin-2; Cystatin-S5",
        "protein_names_refseq": "cystatin 2; cystatin S5; cystatin-SA precursor; cysteine-proteinase inhibitor; salivary cysteine (thiol) protease inhibitor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1470)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11879580;15340161;1778989;20189825;24715725;25946035;27764212;30524438;31376183;3202964;33302616;3436950;3446578;38717526",
        "class_list": "",
        "function": "Cystatin 2 leads to a worse prognosis in patients with gastric cancer., [RefSeq, PubMed]; Cystatin SA attenuates gastric cancer cells growth and increases sensitivity to oxaliplatin via PI3K/AKT signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Interactions of human family 1 & 2 cystatins with cathepsin L1 Publication Status: Online-Only, [RefSeq, PubMed]; The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. [provided by RefSeq, Jul 2008]., [RefSeq]; Thiol protease inhibitor., [UniProtKB]; Tumor biomarker cystatin 2 as part of a four gene transcript score has prognostic value for metastatic-lethal progression in men treated for localized prostate cancer, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UCQ7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031982 vesicle",
        "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "P09228-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14633-1",
        "uniprot_id": "LCE2B_HUMAN",
        "mass": 11219.0,
        "length": 110,
        "protein_name": "Late cornified envelope protein 2B",
        "gene_name": "LCE2B",
        "organism": "Human",
        "refseq_name": "late cornified envelope protein 2B",
        "refseq_ac": "NP_055172",
        "gene_names_uniprotkb": "LCE2B; LEP10; SPRL1B; XP5",
        "gene_names_refseq": "LCE2B; LEP10; SPRL1B; XP5",
        "protein_names_uniprotkb": "Late cornified envelope protein 2B; Late envelope protein 10; Skin-specific protein Xp5; Small proline-rich-like epidermal differentiation complex protein 1B",
        "protein_names_refseq": "late cornified envelope protein 2B; late envelope protein 10; skin-specific protein Xp5; small proline rich-like (epidermal differentiation complex) 1B; small proline-rich-like epidermal differentiation complex protein 1B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26239);  (R-HSA-6809371)",
        "pathway_count": 2,
        "publication_count": 40,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11350120;11380615;11590230;11698679;12902340;15033990;15337775;15797384;15803139;15854049;16061697;16639001;17515931;17562024;17596512;18843291;19190773;19194479;20179351;20657595;20667819;20940292;21439340;21654840;21997417;23629652;25926655;26390218;7543090;8824274;8999895;9344646;9395522;9565599",
        "class_list": "",
        "function": "Paper describing nomenclature changes and expression in range of tissues and in response to UV, [RefSeq, PubMed]; Precursors of the cornified envelope of the stratum corneum., [UniProtKB]; This gene is one of the at least 20 genes expressed during epidermal differentiation and located on chromosomal band 1q21. This gene is involved in epidermal differentiation, and it is expressed at high levels in normal and psoriatic skin, but not in cultured keratinocytes or in any other tested cell types or tissues. [provided by RefSeq, Jul 2008]., [RefSeq]; XP5 is part of a cluster of genes (LEP genes) whose proteins incorporate into keratinocyte cornified envelopes. Strong skin expression confirmed., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TA80",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "",
        "go_biological_process": "GO:0031424 keratinization;GO:0008544 epidermis development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "O14633-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P60412-1",
        "uniprot_id": "KR10B_HUMAN",
        "mass": 30243.0,
        "length": 298,
        "protein_name": "Keratin-associated protein 10-11",
        "gene_name": "KRTAP10-11",
        "organism": "Human",
        "refseq_name": "keratin-associated protein 10-11",
        "refseq_ac": "NP_941965",
        "gene_names_uniprotkb": "KRTAP10-11; KAP10.11; KAP18-11; KRTAP10.11; KRTAP18-11; KRTAP18.11",
        "gene_names_refseq": "KAP10.11; KAP18.11; KRTAP10-11; KRTAP18-11; KRTAP18.11",
        "protein_names_uniprotkb": "Keratin-associated protein 10-11; High sulfur keratin-associated protein 10.11; Keratin-associated protein 10.11; Keratin-associated protein 18-11; Keratin-associated protein 18.11",
        "protein_names_refseq": "high sulfur keratin-associated protein 10.11; keratin associated protein 18-11; keratin-associated protein 10-11; keratin-associated protein 10.11; keratin-associated protein 18.11",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:386678);  (R-HSA-6805567)",
        "pathway_count": 2,
        "publication_count": 12,
        "publication_id_list": "14962103;15028290;15373777;16382671;1691188;1694855;1714783;17521629;23481192;2414304;25208914;9468612",
        "class_list": "",
        "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RRF9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "P60412-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T5A8-1",
        "uniprot_id": "LCE3C_HUMAN",
        "mass": 9729.0,
        "length": 94,
        "protein_name": "Late cornified envelope protein 3C",
        "gene_name": "LCE3C",
        "organism": "Human",
        "refseq_name": "late cornified envelope protein 3C",
        "refseq_ac": "NP_848521",
        "gene_names_uniprotkb": "LCE3C; LEP15; SPRL3A",
        "gene_names_refseq": "LCE3C; LEP15; SPRL3A",
        "protein_names_uniprotkb": "Late cornified envelope protein 3C; Late envelope protein 15; Small proline-rich-like epidermal differentiation complex protein 3A",
        "protein_names_refseq": "late cornified envelope protein 3C; late envelope protein 15; small proline rich-like (epidermal differentiation complex) 3A; small proline-rich-like epidermal differentiation complex protein 3A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:353144);  (R-HSA-6809371)",
        "pathway_count": 2,
        "publication_count": 46,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11350120;11380615;11590230;12902340;15033990;15337775;15797384;15803139;15854049;16061697;16639001;17515931;17562024;17596512;18843291;19169253;19190773;19194479;20016497;20179351;20213803;20657595;20667819;20940292;21439340;21654840;21997417;23629652;25926655;26390218;28634035;29623515;34853291;34942199;36804407;7543090;8824274;8999895;9395522;9565599",
        "class_list": "",
        "function": "A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035)., [UniProtKB, PubMed]; Antimicrobial Late Cornified Envelope Proteins: The Psoriasis Risk Factor Deletion of LCE3B/C Genes Affects Microbiota Composition., [RefSeq, PubMed]; Copy Number Variation Analysis of IL22 and LCE3C in Different Subtypes of Psoriasis in a Chinese Han Population. Publication Status: Online-Only, [RefSeq, PubMed]; Investigation of the clinical characteristics and copy number variations (CNVs) of DEFB4, IL22, and LCE3C in the three subclassifications revealed no significant differences in gender ratio and in Ps area and severity index (PASI) score.  The CNVs of DEFB4 and LCE3C showed no significant differences but the CNV of IL22 significantly differed among the three subclassifications., [RefSeq, PubMed]; LCE3C_LCE3B-del shows epistatic effects with the HLA-Cw6 allele on the development of psoriasis. GeneRIF: Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]; Paper describing nomenclature changes and expression in range of tissues and in response to UV, [RefSeq, PubMed]; Study confirms the recently published finding that the deletion of the two LCE genes is a susceptibility factor for psoriasis vulgaris with dosage effect GeneRIF: Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]; We have verified a pleiotropic effect of a common genetic risk factor (LCE3C_LCE3B-del) for autoimmune diseases that is involved in both psoriasis and rheumatoid arthritis GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L420",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0031424 keratinization;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0031640 killing of cells of another organism",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q5T5A8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BYQ6-1",
        "uniprot_id": "KR411_HUMAN",
        "mass": 20927.0,
        "length": 195,
        "protein_name": "Keratin-associated protein 4-11",
        "gene_name": "KRTAP4-11",
        "organism": "Human",
        "refseq_name": "keratin-associated protein 4-11",
        "refseq_ac": "NP_149048",
        "gene_names_uniprotkb": "KRTAP4-11; KAP4.14; KRTAP4-14; KRTAP4.11; KRTAP4.14",
        "gene_names_refseq": "KAP4.11; KAP4.14; KRTAP4-11; KRTAP4-14; KRTAP4.14",
        "protein_names_uniprotkb": "Keratin-associated protein 4-11; Keratin-associated protein 4-14; Keratin-associated protein 4.11; Keratin-associated protein 4.14; Ultrahigh sulfur keratin-associated protein 4.14",
        "protein_names_refseq": "keratin-associated protein 4-11; keratin-associated protein 4-14; keratin-associated protein 4.11; ultrahigh sulfur keratin-associated protein 4.14",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:653240);  (R-HSA-6805567)",
        "pathway_count": 2,
        "publication_count": 12,
        "publication_id_list": "11279113;15373777;15955084;16382671;1691188;1694855;1714783;17521629;23481192;2414304;25208914;9468612",
        "class_list": "",
        "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]; This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Mar 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AUY2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament",
        "go_biological_process": "GO:0042633 hair cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9BYQ6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0CW20-1",
        "uniprot_id": "LIMS4_HUMAN",
        "mass": 13251.0,
        "length": 117,
        "protein_name": "LIM and senescent cell antigen-like-containing domain protein 4",
        "gene_name": "LIMS4",
        "organism": "Human",
        "refseq_name": "LIM and senescent cell antigen-like-containing domain protein 4 isoform 1",
        "refseq_ac": "NP_001192217",
        "gene_names_uniprotkb": "LIMS4; LIMS3L",
        "gene_names_refseq": "LIMS3L; LIMS4",
        "protein_names_uniprotkb": "LIM and senescent cell antigen-like-containing domain protein 4; LIM and senescent cell antigen-like-containing domain protein 3-like",
        "protein_names_refseq": "LIM and senescent cell antigen-like domains 3-like; LIM and senescent cell antigen-like-containing domain protein 3-like; LIM and senescent cell antigen-like-containing domain protein 4 isoform 1; LIM and senescent cell antigen-like-containing domain protein 4; LIM-type zinc finger domains 4; particularly interesting new Cys-His protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100288695);  (hsa:96626)",
        "pathway_count": 2,
        "publication_count": 4,
        "publication_id_list": "24895689;33912179;35051231;36241641",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9K0W2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "P0CW20-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9GZQ4-1",
        "uniprot_id": "NMUR2_HUMAN",
        "mass": 47696.0,
        "length": 415,
        "protein_name": "Neuromedin-U receptor 2",
        "gene_name": "NMUR2",
        "organism": "Human",
        "refseq_name": "neuromedin-U receptor 2",
        "refseq_ac": "NP_064552",
        "gene_names_uniprotkb": "NMUR2; NMU2R; NMU2; TGR1",
        "gene_names_refseq": "FM-4; FM4; NMU-R2; NMU2R; NMUR2; TGR-1; TGR1",
        "protein_names_uniprotkb": "Neuromedin-U receptor 2; G protein-coupled receptor FM-4; G protein-coupled receptor TGR-1; NMU-R2; TGR-1",
        "protein_names_refseq": "G-protein coupled receptor FM-4; G-protein coupled receptor TGR-1; growth hormone secretagogue receptor family, member 4; neuromedin-U receptor 2",
        "tax_id": 9606,
        "disease": "obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:56923);  (R-HSA-375276);  (R-HSA-416476);  (R-HSA-418594)",
        "pathway_count": 4,
        "publication_count": 134,
        "publication_id_list": "10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10887190;10894543;10899166;11007482;11010960;11015615;11322507;11385580;11457843;11562423;11683476;11742120;11753430;11773063;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15331768;15539556;1567413;15947423;15951850;16182515;16268778;16339447;1655761;16634148;16754659;16923326;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18515384;18577758;18936096;1905813;23446738;23690594;24906252;2534964;26317338;2649896;2748346;27496565;2834384;2841328;28423716;29724789;3086311;3202875;3366244;3525564;35440625;36543808;36575163;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8015379;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8406495;8440682;8463333;8503909;8615752;8664309;8666380;8702752;873923;8823230;9171878;9305846;9521323;9530155;9593744;9607765;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD. Publication Status: Online-Only, [RefSeq, PubMed]; Activation by NMU2 is longer lasting if NmS is the ligand., [RefSeq, PubMed]; G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS) (PubMed:10887190, PubMed:10894543, PubMed:35440625, PubMed:36575163). Functionally, is involved in regulation of feeding and energy balance (By similarity). Additionally may modulates blood pressure and smooth muscle contraction (By similarity). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits (PubMed:11010960, PubMed:15331768, PubMed:35440625, PubMed:36575163). GNAQ/Gaq or GNA11/Ga11 coupling leads to the activation of a phospholipase C (PLC), which hydrolyzes PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate), and subsequent intracellular calcium mobilization via IP3 receptors on the endoplasmic reticulum (PubMed:11010960, PubMed:15331768). GNAI1/Gai coupling inhibits forskolin-stimulated cAMP accumulation (PubMed:15331768)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; NMU might contribute to progression of NMUR2-positive breast cancer, [RefSeq, PubMed]; Study identified a novel NMUR2 splice variant lacking the third exon and able to form heteromeric complexes with NMUR1 and NMUR2 without Neuromedin U (NMU). Its expression can block NMU signaling suppressing then ovarian cancer cells proliferation. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7LC54;Q96AM5;Q9NRA6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005525 GTP binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0008188 neuropeptide receptor activity;GO:0001607 neuromedin U receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0007218 neuropeptide signaling pathway;GO:0007267 cell-cell signaling;GO:0050482 arachidonate secretion;GO:0007417 central nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 13.5,
        "record_id": "Q9GZQ4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NB12-1",
        "uniprot_id": "SMYD1_HUMAN",
        "mass": 56617.0,
        "length": 490,
        "protein_name": "Histone-lysine N-methyltransferase SMYD1",
        "gene_name": "SMYD1",
        "organism": "Human",
        "refseq_name": "histone-lysine N-methyltransferase SMYD1 isoform 1",
        "refseq_ac": "NP_938015",
        "gene_names_uniprotkb": "SMYD1",
        "gene_names_refseq": "BOP; KMT3D; SMYD1; ZMYND18; ZMYND22",
        "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SMYD1; 2.1.1.354; SET and MYND domain-containing protein 1",
        "protein_names_refseq": "CD8 beta opposite; SET and MYND domain-containing protein 1; histone-lysine N-methyltransferase SMYD1 isoform 1; histone-lysine N-methyltransferase SMYD1; zinc finger, MYND domain containing 18",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:150572);  (R-HSA-9733709)",
        "pathway_count": 2,
        "publication_count": 19,
        "publication_id_list": "11237011;12858532;15095414;19162039;19479054;19783823;23481700;25187301;26783251;29557506;29636455;30379171;33054971;33241844;33392160;34944023;35051231;37443729;39091133",
        "class_list": "",
        "function": "Binding Behavior of Human Hepatoma-Derived Growth Factor on SMYD1., [RefSeq, PubMed]; Effects of gene mutations on ventricular development, [RefSeq, PubMed]; HDGF functions as a transcriptional repressor of the SMYD1 gene through interaction with the transcriptional corepressor CtBP., [RefSeq, PubMed]; Lysine Methyltransferase SMYD1 Regulates Myogenesis via skNAC Methylation. Publication Status: Online-Only, [RefSeq, PubMed]; Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis., [UniProtKB, UniProtKB]; Stability of Smyd1 in endothelial cells is controlled by PML-dependent SUMOylation upon cytokine stimulation., [RefSeq, PubMed]; The Methyltransferase Smyd1 Mediates LPS-Triggered Up-Regulation of IL-6 in Endothelial Cells. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AV30;A6NE13",
        "ec_number_list": "2.1.1.354;2.1.1.359;2.1.1.-;2.1.1.355;2.1.1.362;2.1.1.361",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0042800 histone H3K4 methyltransferase activity;GO:0140999 histone H3K4 trimethyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0045892 negative regulation of DNA-templated transcription;GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q8NB12-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P10606-1",
        "uniprot_id": "COX5B_HUMAN",
        "mass": 13696.0,
        "length": 129,
        "protein_name": "Cytochrome c oxidase subunit 5B, mitochondrial",
        "gene_name": "COX5B",
        "organism": "Human",
        "refseq_name": "cytochrome c oxidase subunit 5B, mitochondrial precursor",
        "refseq_ac": "NP_001853",
        "gene_names_uniprotkb": "COX5B",
        "gene_names_refseq": "COX5B; COXVB",
        "protein_names_uniprotkb": "Cytochrome c oxidase subunit 5B, mitochondrial; Cytochrome c oxidase polypeptide Vb",
        "protein_names_refseq": "cytochrome c oxidase polypeptide VB, mitochondrial; cytochrome c oxidase subunit 5B, mitochondrial precursor; cytochrome c oxidase subunit 5B, mitochondrial; cytochrome c oxidase subunit Vb; epididymis secretory sperm binding protein",
        "tax_id": 9606,
        "disease": "autosomal dominant limb-girdle muscular dystrophy (Disease Ontology:DOID:0110273); autosomal recessive limb-girdle muscular dystrophy type 2A (Disease Ontology:DOID:0110275); hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular dystrophy (Disease Ontology:DOID:9884); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:1329);  (R-HSA-5628897);  (R-HSA-611105);  (R-HSA-9707564);  (R-HSA-9837999);  (R-HSA-9864848)",
        "pathway_count": 6,
        "publication_count": 182,
        "publication_id_list": "10327278;10329961;10716435;10745013;10980602;11029283;11034341;11340051;11486029;11545734;11695836;11923310;11959846;12161445;12198491;12203114;12231006;12438239;12453409;12714747;12837546;12869586;12906785;12969439;1327877;13298683;13538944;14623864;14651849;14741580;15105503;15223;15250827;15522782;15589136;15870080;16115876;16140933;16230336;16413492;1646156;16568091;16636147;16728594;16760263;16839880;17033964;17101804;17264172;17297443;17298220;17486094;17540029;17579211;18198340;18344994;186667;18692468;19113821;19439913;19487573;19503089;19690164;19822145;19841671;19968714;20080666;20182617;20351271;20378837;20929863;21654843;21750704;21958598;22262461;22342701;22363791;22427940;22710082;23125284;23150584;23201127;23260140;23270816;23345593;23481700;23564345;23746447;23747254;23775793;23931759;239860;24066844;24315374;24366874;24383451;24403053;24520911;24715725;24718924;25502872;25564869;25576301;25579166;25645385;25926683;25959673;26154972;26321642;26375851;26504172;26652033;26923599;27397612;27452731;27496948;27642048;27693358;28082314;28199844;28228285;28330871;28377575;28396416;2840351;28467828;28698372;28832583;28844695;28904123;29154948;29301859;29557506;29632711;29932645;30030519;30120231;30192525;31327635;31536960;31611695;31695197;31844290;32157095;32317297;32375044;32488085;32502341;32938616;33141586;33257573;33298915;33392160;33912179;33968037;3427020;34357683;34433824;34704252;3475708;34943861;34969438;35051231;35580925;35750769;35870450;36215666;36241641;36629048;38971138;4288886;5666113;6094553;7623837;7979252;7989588;8119488;8313870;8806766;9843204;9878551;9926927",
        "class_list": "",
        "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]; Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008]., [RefSeq]; Heart proteomic profiling discovers MYH6 and COX5B as biomarkers for sudden unexplained death., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
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        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "total_reported_s_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 11,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53YB7;Q96J18;Q99610",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004129 cytochrome-c oxidase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV",
        "go_biological_process": "GO:0007585 respiratory gaseous exchange by respiratory system;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0045333 cellular respiration",
        "synthesized_glycan_count": 0,
        "hit_score": 18.3,
        "record_id": "P10606-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q68CJ9-1",
        "uniprot_id": "CR3L3_HUMAN",
        "mass": 49077.0,
        "length": 461,
        "protein_name": "Cyclic AMP-responsive element-binding protein 3-like protein 3",
        "gene_name": "CREB3L3",
        "organism": "Human",
        "refseq_name": "cyclic AMP-responsive element-binding protein 3-like protein 3 isoform b",
        "refseq_ac": "NP_001258924",
        "gene_names_uniprotkb": "CREB3L3; CREBH; HYST1481",
        "gene_names_refseq": "CREB-H; CREB3L3; CREBH; HYST1481; HYTG2",
        "protein_names_uniprotkb": "Cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H; cAMP-responsive element-binding protein 3-like protein 3",
        "protein_names_refseq": "CREB/ATF family transcription factor; cAMP-responsive element-binding protein, hepatic-specific; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform b; cyclic AMP-responsive element-binding protein 3-like protein 3",
        "tax_id": 9606,
        "disease": "hypertriglyceridemia 2 (MONDO:MONDO:0859149)",
        "pathway": " (hsa:84699);  (R-HSA-8874211);  (R-HSA-8963889)",
        "pathway_count": 3,
        "publication_count": 69,
        "publication_id_list": "10900462;11353085;11830526;12138176;1301939;15221005;15284087;15800215;16109723;16236796;16469704;16940180;17088546;17117415;17712038;17875199;17883852;17924679;17994020;17997385;18391022;19304573;19361614;19883396;20356926;20546900;20581395;21666694;21719679;21767813;21844202;22171320;22262056;22569073;22705851;22740495;23020258;23150577;23256041;24126059;24275569;24397894;24909692;24960069;25387803;25625847;25955804;26427795;26810754;26933753;26934567;26934667;28381424;29557506;29738435;30389664;30459171;31154438;32580631;34491909;35580925;36649378;37074911;7592670;8020465;8485124;9136889;9271389;9379936",
        "class_list": "",
        "function": "A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity., [RefSeq, PubMed]; Analysis of CREB-H trafficking into alternate pathways of ERAD and stress-regulated intramembrane proteolysis, [RefSeq, PubMed]; CREBH has a crucial role in glucose and lipid metabolism in the liver and small intestine. Review article Publication Status: Online-Only, [RefSeq, PubMed]; CREBH normalizes dyslipidemia and halts atherosclerosis in diabetes by decreasing circulating remnant lipoproteins., [RefSeq, PubMed]; Loss-of-Function CREB3L3 Variants in Patients With Severe Hypertriglyceridemia., [RefSeq, PubMed]; This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]., [RefSeq]; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations (PubMed:21666694)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_o_glycosites": 1,
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        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 2,
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        "total_n_glycosites": 3,
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        "reported_phosphosites": 6,
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        "missing_score": 9015,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7S6;B7ZL69;M0QYW7;Q6ZMC5;Q96TB9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002675 positive regulation of acute inflammatory response;GO:0034976 response to endoplasmic reticulum stress",
        "synthesized_glycan_count": 0,
        "hit_score": 8.1,
        "record_id": "Q68CJ9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T5B0-1",
        "uniprot_id": "LCE3E_HUMAN",
        "mass": 9507.0,
        "length": 92,
        "protein_name": "Late cornified envelope protein 3E",
        "gene_name": "LCE3E",
        "organism": "Human",
        "refseq_name": "late cornified envelope protein 3E",
        "refseq_ac": "NP_848522",
        "gene_names_uniprotkb": "LCE3E; LEP17",
        "gene_names_refseq": "LCE3E; LEP17",
        "protein_names_uniprotkb": "Late cornified envelope protein 3E; Late envelope protein 17",
        "protein_names_refseq": "late cornified envelope protein 3E; late envelope protein 17",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:353145);  (R-HSA-6809371)",
        "pathway_count": 2,
        "publication_count": 39,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11350120;11380615;11590230;12902340;15033990;15337775;15797384;15803139;15854049;16061697;16639001;17515931;17562024;17596512;18843291;19190773;19194479;20179351;20657595;20667819;20940292;21439340;21654840;21997417;23629652;25926655;26390218;36804407;7543090;8824274;8999895;9395522;9565599",
        "class_list": "",
        "function": "Paper describing nomenclature changes and expression in range of tissues and in response to UV, [RefSeq, PubMed]; Precursors of the cornified envelope of the stratum corneum., [UniProtKB]",
        "predicted_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
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        "secondary_ac_list": "A2RRM6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0031424 keratinization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q5T5B0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96BZ8-1",
        "uniprot_id": "LENG1_HUMAN",
        "mass": 30528.0,
        "length": 264,
        "protein_name": "Leukocyte receptor cluster member 1",
        "gene_name": "LENG1",
        "organism": "Human",
        "refseq_name": "leukocyte receptor cluster member 1",
        "refseq_ac": "NP_077292",
        "gene_names_uniprotkb": "LENG1",
        "gene_names_refseq": "LENG1",
        "protein_names_uniprotkb": "Leukocyte receptor cluster member 1",
        "protein_names_refseq": "leukocyte receptor cluster (LRC) member 1; leukocyte receptor cluster member 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79165);  (R-HSA-72163)",
        "pathway_count": 2,
        "publication_count": 93,
        "publication_id_list": "10882114;10941842;11014198;11101529;11233976;11991638;12176931;12411573;12414731;12477934;14625303;14713954;16314458;16809785;17095540;17332742;17525332;17606899;18322460;18593880;18669648;19103666;19165350;19536130;19690332;20068231;20423332;20980672;21536652;2176635;22110043;22365833;22959432;22961380;23186163;23222130;23236153;23345524;24196718;24304693;24448447;24737827;24914973;25555158;2558966;26385511;26420826;26969736;27377154;27459055;27683217;28062851;28063628;28076346;28502770;28781166;28832583;29242379;29301961;29360106;29361316;29393594;29485866;29632046;29632711;2963332;30315277;30705154;30728453;30765414;30975767;31409651;31848261;31998317;32179686;32329775;32494006;33243851;33446560;34301950;34822310;35385551;3757028;8566756;8608946;9016565;9242493;9512519;9524131;9539711;9671485;9701291;9731529",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q9HCU7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 9.6,
        "record_id": "Q96BZ8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BYE3-1",
        "uniprot_id": "LCE3D_HUMAN",
        "mass": 9444.0,
        "length": 92,
        "protein_name": "Late cornified envelope protein 3D",
        "gene_name": "LCE3D",
        "organism": "Human",
        "refseq_name": "late cornified envelope protein 3D",
        "refseq_ac": "NP_115952",
        "gene_names_uniprotkb": "LCE3D; LEP16; SPRL6A; SPRL6B",
        "gene_names_refseq": "LCE3D; LEP16; SPRL6A; SPRL6B",
        "protein_names_uniprotkb": "Late cornified envelope protein 3D; Late envelope protein 16; Small proline-rich-like epidermal differentiation complex protein 6A; Small proline-rich-like epidermal differentiation complex protein 6B",
        "protein_names_refseq": "late cornified envelope protein 3D; late envelope protein 16; small proline rich-like (epidermal differentiation complex) 6A; small proline rich-like (epidermal differentiation complex) 6B; small proline-rich-like epidermal differentiation complex protein 6A; small proline-rich-like epidermal differentiation complex protein 6B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84648);  (R-HSA-6809371)",
        "pathway_count": 2,
        "publication_count": 43,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11350120;11380615;11590230;11698679;12902340;15033990;15337775;15797384;15803139;15854049;16061697;16639001;17515931;17562024;17596512;18843291;19169255;19190773;19194479;20179351;20657595;20667819;20940292;21208785;21439340;21654840;21997417;23629652;25926655;26390218;29397434;36804407;7543090;8824274;8999895;9395522;9565599",
        "class_list": "",
        "function": "Genetic polymorphism is associated with psoriasis vulgaris among Mongolians from Inner Mongolia, [RefSeq, PubMed]; LEP16 is one of a cluster of 16-20 related genes at 1q21 which includes XP5. Proteins incorporate into the cornified envelope of stratified, terminally differentiating epithelia. LEP16 transcripts detected in heart, skin and esophagus., [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Paper describing nomenclature changes and expression in range of tissues and in response to UV, [RefSeq, PubMed]; Precursors of the cornified envelope of the stratum corneum., [UniProtKB]; We identified significant combined effects between MHC and LCE, MHC and IL12B on the risk of psoriasis in Chinese population., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "secondary_ac_list": "Q3MIL1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0031424 keratinization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "Q9BYE3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N4P2-1",
        "uniprot_id": "IT70B_HUMAN",
        "mass": 76099.0,
        "length": 665,
        "protein_name": "Intraflagellar transport protein 70B",
        "gene_name": "IFT70B",
        "organism": "Human",
        "refseq_name": "intraflagellar transport protein 70B",
        "refseq_ac": "NP_689730",
        "gene_names_uniprotkb": "IFT70B; TTC30B",
        "gene_names_refseq": "IFT70B; IFT70; TTC30B; fleer",
        "protein_names_uniprotkb": "Intraflagellar transport protein 70B; TPR repeat protein 30B; Tetratricopeptide repeat protein 30B",
        "protein_names_refseq": "TPR repeat protein 30B; intraflagellar transport protein 70B; tetratricopeptide repeat domain 30B; tetratricopeptide repeat protein 30B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:150737);  (R-HSA-5620924)",
        "pathway_count": 2,
        "publication_count": 75,
        "publication_id_list": "10069812;11285270;12795688;15231740;15269286;15489852;15523559;15955805;16049494;16435301;16492809;16775004;16782012;17312020;17314406;17574030;18180368;18304522;18364699;18369462;18852297;19112494;19147001;19253336;19384852;19450523;19720863;19805633;20435895;20526327;20526328;20530210;20889716;21427764;21936775;22118932;22922713;22992454;23945166;23990561;24140113;24296415;24596149;24616010;25205765;25349261;25443296;26992070;30379171;30429286;31154438;31306809;32157095;32357974;32938616;33298915;33592498;33691108;33717175;33912179;33936100;33968037;34087483;34185709;35051231;35580925;36010968;36241641;36284347;8516294;8522608;9114011;9585416;9585417;9852153",
        "class_list": "",
        "function": "A rare TTC30B variant is identified as a candidate for synpolydactyly in a Chinese pedigree., [RefSeq, PubMed]; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q63HQ1;Q96NE6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0120170 intraciliary transport particle B binding",
        "go_cellular_component": "GO:0005929 cilium;GO:0005879 axonemal microtubule;GO:0030991 intraciliary transport particle A;GO:0030992 intraciliary transport particle B;GO:0097542 ciliary tip",
        "go_biological_process": "GO:0060271 cilium assembly;GO:0042073 intraciliary transport;GO:0035720 intraciliary anterograde transport",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q8N4P2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N5C8-1",
        "uniprot_id": "TAB3_HUMAN",
        "mass": 78653.0,
        "length": 712,
        "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3",
        "gene_name": "TAB3",
        "organism": "Human",
        "refseq_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 1",
        "refseq_ac": "NP_690000",
        "gene_names_uniprotkb": "TAB3; MAP3K7IP3",
        "gene_names_refseq": "MAP3K7IP3; NAP1; TAB3",
        "protein_names_uniprotkb": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; TAB-3; TAK1-binding protein 3; TGF-beta-activated kinase 1-binding protein 3",
        "protein_names_refseq": "NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; TAK1-binding protein 3; TGF-beta activated kinase 1 and MAP3K7 binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 1; TGF-beta-activated kinase 1-binding protein 3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3",
        "tax_id": 9606,
        "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074)",
        "pathway": " (hsa:257397);  (R-HSA-168638);  (R-HSA-2871837);  (R-HSA-445989);  (R-HSA-450302);  (R-HSA-450321);  (R-HSA-5357956);  (R-HSA-5607764);  (R-HSA-9014325);  (R-HSA-9020702);  (R-HSA-937042);  (R-HSA-937072);  (R-HSA-9645460);  (R-HSA-9705671);  (R-HSA-975163)",
        "pathway_count": 15,
        "publication_count": 228,
        "publication_id_list": "10075690;10187770;10224040;10329646;10514433;10702308;10723127;10779524;10838074;10854325;10882101;10918611;11053425;11057907;11087742;11090634;11094434;11237011;11262391;11323434;11325957;11460167;11606584;11772397;11960013;12019269;12171911;12242293;12473183;12473184;12496252;12514169;12527755;12538665;12609980;12692549;12759408;12791687;12791997;12796777;12860405;12917691;14514672;14625308;14633987;14670075;14766965;15105418;15125833;15145317;15208624;15327770;15492226;15620648;15814722;15837794;15845454;15917247;16056267;16186825;16252004;16260493;16260783;16282325;16289117;16306937;16341139;16356853;16356856;16603398;16831874;16953224;16978534;17047224;17135271;17141195;17158449;17303577;17428801;17449468;17496917;17507369;17562858;17675297;17728323;17878161;17890055;17948050;17997719;18021073;18070982;18079694;18180283;1828071;1833184;18438411;18462684;18669648;18772140;19112497;19264966;19359218;19521662;19535145;19675569;19903815;19934406;19935683;20005846;20038579;20047764;20068231;20193029;20300203;20385093;20538596;20685844;2139180;2147937;21512573;21525931;21966355;22069318;22158122;22265677;22798961;22941947;23186163;23301498;24074955;24275569;24434549;25642820;26389808;27009840;27445336;27466718;27701768;27862975;28514659;29351928;2946959;30111836;30379171;30429286;30455202;31492838;31844290;31850239;32353859;32428392;32589897;32726803;32728199;32819610;32953130;32979938;33024073;33060197;33097660;33110251;33349665;33360543;33372174;33372854;33396605;33440148;33479219;33495715;33514628;33567255;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33963333;33968037;33989516;33990585;34019948;34021074;34054808;34084167;34110168;34166398;34239064;34290717;34341353;34375313;34400613;34439781;34452305;34471099;34502139;34597346;35051231;35102342;35643212;36593296;37051252;37203408;37541260;39531497;7499357;7612269;7628694;8327496;8332913;8533096;8599092;8622669;8638164;8837778;8972730;9346484;9371760;9430229;9430721;9744859;9768359;9859996;9865693;9990852;9990853",
        "class_list": "",
        "function": "Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; May be an oncogenic factor., [UniProtKB, PubMed]; MiR-27a-3p upregulation by p65 facilitates cervical tumorigenesis by increasing TAB3 expression and is involved in the positive feedback loop of NF-kappaB signaling., [RefSeq, PubMed]; Neddylation promotes protein translocation between the cytoplasm and nucleus., [RefSeq, PubMed]; The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NDD9;Q6VQR0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0043130 ubiquitin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0010507 negative regulation of autophagy;GO:0042742 defense response to bacterium;GO:0007249 canonical NF-kappaB signal transduction;GO:0038061 non-canonical NF-kappaB signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 23.8,
        "record_id": "Q8N5C8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14106-1",
        "uniprot_id": "TOB2_HUMAN",
        "mass": 36632.0,
        "length": 344,
        "protein_name": "Protein Tob2",
        "gene_name": "TOB2",
        "organism": "Human",
        "refseq_name": "protein Tob2",
        "refseq_ac": "NP_057356",
        "gene_names_uniprotkb": "TOB2; KIAA1663; TOB4; TROB2",
        "gene_names_refseq": "APRO5; TOB2; TOB4; TOBL; TROB2",
        "protein_names_uniprotkb": "Protein Tob2; Protein Tob4; Transducer of erbB-2 2",
        "protein_names_refseq": "protein Tob2; protein Tob4; transducer of erbB-2 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10766)",
        "pathway_count": 1,
        "publication_count": 50,
        "publication_id_list": "10602502;11237011;11258795;18477386;19690332;25418920;25576301;25645385;25880248;26375851;26811146;26992070;27397612;28228285;28832583;28904123;29242379;29393594;29557506;29632046;29769354;29789417;30429286;31154438;31217245;31492838;31530632;31844290;31848261;32265295;32387766;32404348;32488085;32619704;32938616;32983136;33298915;33592498;33691108;33912179;33968037;34171305;35051231;35254053;35318648;35580925;36241641;36284347;37541260;37938771",
        "class_list": "",
        "function": "Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases., [UniProtKB]; MiR-375 promotes human periodontal ligament stem cells proliferation and osteogenic differentiation by targeting transducer of ERBB2, 2., [RefSeq, PubMed]; TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]., [RefSeq]; Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6FHR7;Q6PIT9;Q9BY97;Q9UBI0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042809 nuclear vitamin D receptor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0010468 regulation of gene expression;GO:0007292 female gamete generation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q14106-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95229-1",
        "uniprot_id": "ZWINT_HUMAN",
        "mass": 31293.0,
        "length": 277,
        "protein_name": "Outer kinetochore KNL1 complex subunit ZWINT",
        "gene_name": "ZWINT",
        "organism": "Human",
        "refseq_name": "outer kinetochore KNL1 complex subunit ZWINT isoform b",
        "refseq_ac": "NP_001005413",
        "gene_names_uniprotkb": "ZWINT",
        "gene_names_refseq": "HZwint-1; KNTC2AP; SIP30; ZWINT1; ZWINT",
        "protein_names_uniprotkb": "Outer kinetochore KNL1 complex subunit ZWINT; ZW10 interactor; ZW10-interacting protein 1; Zwint-1",
        "protein_names_refseq": "SNAP25 interacting protein of 30 kDa; ZW10 interactor, kinetochore protein; human ZW10 interacting protein-1; outer kinetochore KNL1 complex subunit ZWINT isoform b; outer kinetochore KNL1 complex subunit ZWINT; zwint-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11130);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5663220);  (R-HSA-68877);  (R-HSA-9648025)",
        "pathway_count": 8,
        "publication_count": 165,
        "publication_id_list": "10411507;10600384;10678165;10806105;10958683;11081627;11181178;11237011;11371342;11509732;11535616;11804586;12006501;12194817;12429848;12577064;12679384;12732141;12805219;12852857;14730319;15006353;15085137;15094189;15339662;15485811;15502821;15507212;15723797;15737063;15824131;15864301;15866170;15944396;16292343;16439214;16541025;16622419;16622420;16682347;16732327;16890222;16943183;17030981;17112726;17113138;17129783;17196341;17198702;1737036;18001770;18097444;18716626;18923426;19007248;19350017;19691289;19696148;19815554;19965387;20030946;20101212;20591975;21111234;21148482;21397845;21576392;21775627;21868368;21878504;21987589;22094460;22275430;22424782;22608513;22790947;22885700;23222643;23481700;23801653;24366607;24530301;24714562;24914801;25418920;25505266;25576301;25740311;25789526;26154972;26375851;26728094;26758079;26992070;27397612;27543614;27600516;27846572;27881301;27920218;28228285;28649982;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29769354;30315122;30484775;30524438;30779550;31154438;31217245;31409757;31530632;31844290;31848261;32157095;32161166;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33607172;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34260926;34405274;34509645;34561969;34932366;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37929349;37938771;38459127;38459128;9649308;9649503;9892021",
        "class_list": "",
        "function": "Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15094189, PubMed:15485811, PubMed:15824131, PubMed:16732327, PubMed:24530301, PubMed:27881301, PubMed:38459127, PubMed:38459128). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:15094189, PubMed:15485811, PubMed:16732327). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:15094189, PubMed:15485811, PubMed:15824131, PubMed:16732327, PubMed:24530301, PubMed:38459127, PubMed:38459128). Targets the RZZ complex to the kinetochore at prometaphase (PubMed:15485811). Recruits MAD2L1 to the kinetochore, but is not required for BUB1B localization (By similarity). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (PubMed:15485811)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Genome-wide association analysis of cognitive function in Danish long-lived individuals., [RefSeq, PubMed]; Show that ZW10 interacting protein-1(Zwint-1) is required and is sufficient for kinetochore localization of Zeste White 10 (ZW10) in HeLa cells, [RefSeq, PubMed]; This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; ZWINT promotes the proliferation, migration, and invasion of cervical cancer cells by regulating the p53/p21 signaling pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NNV6;Q0D2I3;Q9BWD0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0016604 nuclear body",
        "go_biological_process": "GO:0031619 homologous chromosome orientation in meiotic metaphase I;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0051649 establishment of localization in cell;GO:0000070 mitotic sister chromatid segregation",
        "synthesized_glycan_count": 0,
        "hit_score": 16.6,
        "record_id": "O95229-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IYI6-1",
        "uniprot_id": "EXOC8_HUMAN",
        "mass": 81799.0,
        "length": 725,
        "protein_name": "Exocyst complex component 8",
        "gene_name": "EXOC8",
        "organism": "Human",
        "refseq_name": "exocyst complex component 8",
        "refseq_ac": "NP_787072",
        "gene_names_uniprotkb": "EXOC8",
        "gene_names_refseq": "EXO84; EXOC8; Exo84p; NEDMISB; SEC84",
        "protein_names_uniprotkb": "Exocyst complex component 8; Exocyst complex 84 kDa subunit",
        "protein_names_refseq": "exocyst complex 84 kDa subunit; exocyst complex component 8",
        "tax_id": 9606,
        "disease": "neurodevelopmental disorder with microcephaly, seizures, and brain atrophy (MONDO:MONDO:0033662)",
        "pathway": " (hsa:149371);  (R-HSA-1445148);  (R-HSA-264876);  (R-HSA-5620916)",
        "pathway_count": 4,
        "publication_count": 139,
        "publication_id_list": "10521251;11462236;11493706;11707400;11904301;12221131;14525976;14617756;14704853;15158452;1528899;15331542;15728366;15878854;15919790;15971998;16038802;16136078;16155582;16158220;16158222;16407158;16431365;16537653;16714477;16782012;16880201;16984975;17007872;17030804;17369524;17574030;17628206;17646400;17924679;17956946;17995453;18452278;18669648;18685082;18756269;19013499;19017632;19153612;19252894;19297529;19454479;20083215;20308425;20308558;20631154;20701589;20837646;20937701;21091435;21145486;21273506;21308844;21454505;21454690;21550243;21565611;21658605;21713314;21775626;21907143;22389062;22420621;22433857;22700954;22761837;22983554;23186163;23351793;23481700;23567335;23945166;24296415;24715725;25091901;2550440;25576301;25880248;2669954;26992070;27600516;27846572;28063628;2822027;28228285;28832583;28834231;28904123;29242379;29393594;29493099;29557506;29632046;29786170;30315122;30379171;30429286;31154438;31184304;31844290;31848261;32103185;32157095;32357974;32387766;32502341;32723473;32938616;33123756;33141586;33298915;33485965;33592498;33717175;33912179;33968037;34171305;34357683;34509645;34932366;35051231;35580925;36215666;36284347;3896518;40914422;7626024;8094051;8664345;8916141;9166668;9207799;9631292;9819391",
        "class_list": "",
        "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]; Evidence that mammalian exocyst components are present as distinct subcomplexes on vesicles and the plasma membrane and that Ral GTPases regulate the assembly interface of a full octameric exocyst complex through interaction with Sec5 and Exo84, [RefSeq, PubMed]; This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016]., [RefSeq]; We identified interactions between RalA and its effectors sec5 and exo84 in the Exocyst complex as directly necessary for migration and invasion of prostate cancer tumor cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KU33;Q5TE82",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031267 small GTPase binding;GO:0035091 phosphatidylinositol binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030426 growth cone;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0015031 protein transport;GO:0022617 extracellular matrix disassembly;GO:0016241 regulation of macroautophagy;GO:0007032 endosome organization;GO:0000281 mitotic cytokinesis",
        "synthesized_glycan_count": 0,
        "hit_score": 14.2,
        "record_id": "Q8IYI6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T7P3-1",
        "uniprot_id": "LCE1B_HUMAN",
        "mass": 11626.0,
        "length": 118,
        "protein_name": "Late cornified envelope protein 1B",
        "gene_name": "LCE1B",
        "organism": "Human",
        "refseq_name": "late cornified envelope protein 1B",
        "refseq_ac": "NP_848126",
        "gene_names_uniprotkb": "LCE1B; LEP2; SPRL2A",
        "gene_names_refseq": "LCE1B; LEP2; SPRL2A",
        "protein_names_uniprotkb": "Late cornified envelope protein 1B; Late envelope protein 2; Small proline-rich-like epidermal differentiation complex protein 2A",
        "protein_names_refseq": "late cornified envelope protein 1B; late envelope protein 2; small proline rich-like (epidermal differentiation complex) 2A; small proline-rich-like epidermal differentiation complex protein 2A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:353132);  (R-HSA-6809371)",
        "pathway_count": 2,
        "publication_count": 40,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11350120;11380615;11590230;12902340;15033990;15337775;15797384;15803139;15854049;16061697;16639001;17515931;17562024;17596512;18843291;19190773;19194479;20179351;20657595;20667819;20940292;21439340;21654840;21997417;23629652;25926655;26390218;29397434;36804407;7543090;8824274;8999895;9395522;9565599",
        "class_list": "",
        "function": "Genetic polymorphism is associated with psoriasis vulgaris among Mongolians from Inner Mongolia, [RefSeq, PubMed]; Paper describing nomenclature changes and expression in range of tissues and in response to UV, [RefSeq, PubMed]; Precursors of the cornified envelope of the stratum corneum., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4IF40",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "",
        "go_biological_process": "GO:0031424 keratinization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q5T7P3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5TA82-1",
        "uniprot_id": "LCE2D_HUMAN",
        "mass": 11180.0,
        "length": 110,
        "protein_name": "Late cornified envelope protein 2D",
        "gene_name": "LCE2D",
        "organism": "Human",
        "refseq_name": "late cornified envelope protein 2D",
        "refseq_ac": "NP_848517",
        "gene_names_uniprotkb": "LCE2D; LEP12; SPRL1A",
        "gene_names_refseq": "LCE2D; LEP12; SPRL1A",
        "protein_names_uniprotkb": "Late cornified envelope protein 2D; Late envelope protein 12; Small proline-rich-like epidermal differentiation complex protein 1A",
        "protein_names_refseq": "late cornified envelope protein 2D; late envelope protein 12; small proline rich-like (epidermal differentiation complex) 1A; small proline-rich-like epidermal differentiation complex protein 1A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:353141);  (R-HSA-6809371)",
        "pathway_count": 2,
        "publication_count": 38,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11350120;11380615;11590230;12902340;15033990;15337775;15797384;15803139;15854049;16061697;16639001;17515931;17562024;17596512;18843291;19190773;19194479;20179351;20657595;20667819;20940292;21439340;21654840;21997417;23629652;25926655;26390218;7543090;8824274;8999895;9395522;9565599",
        "class_list": "",
        "function": "Paper describing nomenclature changes and expression in range of tissues and in response to UV, [RefSeq, PubMed]; Precursors of the cornified envelope of the stratum corneum., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4M8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0031424 keratinization",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "Q5TA82-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WUD1-1",
        "uniprot_id": "RAB2B_HUMAN",
        "mass": 24214.0,
        "length": 216,
        "protein_name": "Ras-related protein Rab-2B",
        "gene_name": "RAB2B",
        "organism": "Human",
        "refseq_name": "ras-related protein Rab-2B isoform 2",
        "refseq_ac": "NP_001156852",
        "gene_names_uniprotkb": "RAB2B",
        "gene_names_refseq": "RAB2B",
        "protein_names_uniprotkb": "Ras-related protein Rab-2B; 3.6.5.2",
        "protein_names_refseq": "GTP-binding protein RAB2B; RAS family, member RAB2B; ras-related protein Rab-2B isoform 2; ras-related protein Rab-2B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84932);  (R-HSA-8873719)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "11141079;11237011;11389151;11447212;11675392;12376746;16401880;1648736;17114793;17411337;18532927;19603039;22694141;23186163;24023390;25341920;25892735;26209634;26969162;28483915;28649982;28832583;29242379;29393594;29557506;29786170;30015954;30573663;31020640;31154438;31844290;31848261;32265295;32350084;32357974;33592498;33968037;34171305;34185709;34433824;34725712;34932366;35251023;36010968;37074911;40307207;7957092;7991565;8164745;8349690;8375503;8513495;8631982;8662963;8836150",
        "class_list": "",
        "function": "Data show that Rab2B and a Rab2B-specific effector, GARI-L4, regulate Golgi morphology., [RefSeq, PubMed]; High RAB2B expression is associated with pancreatic cancer., [RefSeq, PubMed]; Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006]., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28483915)., [UniProtKB, UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
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        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RD03;D3DS24;Q6NZ33",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.1.-;2.5.1.60;3.6.5.4;2.7.11.1;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0015031 protein transport;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0016236 macroautophagy;GO:0016192 vesicle-mediated transport",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "Q8WUD1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z2X4-1",
        "uniprot_id": "PCLI1_HUMAN",
        "mass": 28272.0,
        "length": 250,
        "protein_name": "PTB-containing, cubilin and LRP1-interacting protein",
        "gene_name": "PID1",
        "organism": "Human",
        "refseq_name": "PTB-containing, cubilin and LRP1-interacting protein isoform 2",
        "refseq_ac": "NP_001094288",
        "gene_names_uniprotkb": "PID1; HMFN2073; NYGGF4; PCLI1",
        "gene_names_refseq": "HMFN2073; NYGGF4; P-CLI1; PCLI1; PID1",
        "protein_names_uniprotkb": "PTB-containing, cubilin and LRP1-interacting protein; P-CLI1; Phosphotyrosine interaction domain-containing protein 1; Protein NYGGF4",
        "protein_names_refseq": "PTB-containing, cubilin and LRP1-interacting protein isoform 2; PTB-containing, cubilin and LRP1-interacting protein; phosphotyrosine interaction domain-containing protein 1",
        "tax_id": 9606,
        "disease": "asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)",
        "pathway": " (hsa:55022)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;15221005;16815647;17124247;19079291;20165904;22284633;24300787;25576301;29557506;30100244;30429286;31154438;31339628;31844290;32157095;32938616;32983136;36241641;37217939",
        "class_list": "",
        "function": "A novel gene named NYGGF4, which was expressed at a higher level in obese subjects, was isolated and characterized and could play a role in cell growth and adipogenesis process, [RefSeq, PubMed]; By acting as an insulin-dependent retention adaptor, PID1 serves as a regulator of LRP1 function controlling the disposal of postprandial lipoproteins., [RefSeq, PubMed]; Data show that NYGGF4 regulates the functions of IRS-1 and Akt, decreases GLUT4 translocation and reduces glucose uptake in response to insulin., [RefSeq, PubMed]; Increases proliferation of preadipocytes without affecting adipocytic differentiation., [UniProtKB, PubMed]; NYGGF4 acts directly on the IRS1/PI3K/AKT insulin pathway to reduce glucose uptake and transport, impairs mitochondrial function and causes insulin resistance, and thus may be a useful therapeutic target for obesity-associated insulin resistance., [RefSeq, PubMed]; Overall survival and radiation-free progression-free survival were longer in medulloblastoma patients whose tumors had higher PID1 mRNA levels. Erratum:[Clin Cancer Res. 2015 Sep 15;21(18):4243. doi: 10.1158/1078-0432.CCR-15-1523. Asgharazadeh, Shahab [corrected to Asgharzadeh, Shahab]. PMID: 26374075], [RefSeq, PubMed]; Overexpression of NYGGF4 caused mitochondrial dysfunction in adipocytes, which might be responsible for the development of NYGGF4-induced insulin resistance., [RefSeq, PubMed]; PID1 reduces serum HDL-Cholesterol levels., [RefSeq, PubMed]; Q7Z2X4 protein (PID1) identified as a cytosolic ligand of LRP1 in a trimeric complex with Cubilin. Q7Z2X4 named PCLI1 (PTB-containing, Cubilin and LRP1 Interacting protein 1), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KU82;Q68CJ2;Q6ZUS3;Q8IXL0;Q9NWP6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:2001171 positive regulation of ATP biosynthetic process;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051881 regulation of mitochondrial membrane potential",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q7Z2X4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P49792-1",
        "uniprot_id": "RBP2_HUMAN",
        "mass": 358199.0,
        "length": 3224,
        "protein_name": "E3 SUMO-protein ligase RanBP2",
        "gene_name": "RANBP2",
        "organism": "Human",
        "refseq_name": "E3 SUMO-protein ligase RanBP2 isoform 1",
        "refseq_ac": "NP_006258",
        "gene_names_uniprotkb": "RANBP2; NUP358",
        "gene_names_refseq": "ADANE; ANE1; IIAE3; NUP358; RANBP2; TRP1; TRP2",
        "protein_names_uniprotkb": "E3 SUMO-protein ligase RanBP2; 2.3.2.-; 358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2; RanBP2; p270",
        "protein_names_refseq": "358 kDa nucleoporin; E3 SUMO-protein ligase RanBP2 isoform 1; E3 SUMO-protein ligase RanBP2; E3 SUMO-protein transferase RanBP2; P270; acute necrotizing encephalopathy 1 (autosomal dominant); nuclear pore complex protein Nup358; nucleoporin 358; nucleoporin Nup358; ran-binding protein 2; transformation-related protein 2",
        "tax_id": 9606,
        "disease": "inflammatory myofibroblastic tumor (Disease Ontology:DOID:0050905); brain disease (Disease Ontology:DOID:936); multiple myeloma (Disease Ontology:DOID:9538); familial acute necrotizing encephalopathy (MONDO:MONDO:0011953)",
        "pathway": " (hsa:5903);  (R-HSA-1169408);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-159227);  (R-HSA-159230);  (R-HSA-159231);  (R-HSA-159236);  (R-HSA-165054);  (R-HSA-168271);  (R-HSA-168276);  (R-HSA-168325);  (R-HSA-168333);  (R-HSA-170822);  (R-HSA-180746);  (R-HSA-180910);  (R-HSA-1855170);  (R-HSA-1855196);  (R-HSA-1855229);  (R-HSA-191859);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-3108214);  (R-HSA-3232142);  (R-HSA-3301854);  (R-HSA-3371453);  (R-HSA-4085377);  (R-HSA-4551638);  (R-HSA-4570464);  (R-HSA-4615885);  (R-HSA-5619107);  (R-HSA-5663220);  (R-HSA-6784531);  (R-HSA-68877);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9648025);  (R-HSA-9705671);  (R-HSA-9725370)",
        "pathway_count": 39,
        "publication_count": 740,
        "publication_id_list": 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        "class_list": "",
        "function": "Association of RAN and RANBP2 Gene Polymorphisms With Glioma Susceptibility in Chinese Children., [RefSeq, PubMed]; Aurora B SUMOylation Is Restricted to Centromeres in Early Mitosis and Requires RANBP2. Publication Status: Online-Only, [RefSeq, PubMed]; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Intense work-up is required for pediatric COVID-related acute necrotizing encephalopathy with RANBP2 variants., [RefSeq, PubMed]; RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]., [RefSeq]; Reports identification of the cyclophilin-related protein, RanBP2 (note at the time the protein was not designated RanBP2), and the cis-trans prolyl isomerase activity of its cyclophilin domain, [RefSeq, PubMed]; Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 78,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 78,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 78,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 118,
        "reported_mutagensis": 18,
        "reported_glycation": 0,
        "reported_snv": 177,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 4,
        "glyco_site_count": 81,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q13074;Q15280;Q53TE2;Q59FH7",
        "ec_number_list": "3.6.5.-;2.7.11.1;3.1.3.16;2.7.11.22;2.7.11.23;3.6.4.10;5.6.2.2;2.3.2.-;2.7.1.1;2.7.1.-;3.6.4.13;6.1.1.16;2.7.11.21;3.5.1.98;3.6.5.2;2.3.2.27;3.4.22.49;3.6.4.12;2.7.11.38;2.7.11.34;2.3.2.24;2.7.10.2;3.6.1.15;3.1.27.-",
        "go_molecular_function": "GO:0019209 kinase activator activity;GO:0061665 SUMO ligase activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity",
        "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006913 nucleocytoplasmic transport;GO:0016925 protein sumoylation;GO:0001975 response to amphetamine;GO:0006457 protein folding",
        "synthesized_glycan_count": 0,
        "hit_score": 82.8,
        "record_id": "P49792-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UKV0-1",
        "uniprot_id": "HDAC9_HUMAN",
        "mass": 111297.0,
        "length": 1011,
        "protein_name": "Histone deacetylase 9",
        "gene_name": "HDAC9",
        "organism": "Human",
        "refseq_name": "histone deacetylase 9 isoform 6 precursor",
        "refseq_ac": "NP_001191073",
        "gene_names_uniprotkb": "HDAC9; HDAC7B; HDAC7; HDRP; KIAA0744; MITR",
        "gene_names_refseq": "HD7b; HD7; HD9; HDAC7B; HDAC9B; HDAC9FL; HDAC9; HDAC; HDRP; MITR",
        "protein_names_uniprotkb": "Histone deacetylase 9; 3.5.1.98; HD7b; HD7; HD9; Histone deacetylase 7B; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR",
        "protein_names_refseq": "MEF-2 interacting transcription repressor (MITR) protein; histone deacetylase 4/5-related protein; histone deacetylase 7B; histone deacetylase 9 isoform 6 precursor",
        "tax_id": 9606,
        "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525); auriculocondylar syndrome 4 (MONDO:MONDO:0957543)",
        "pathway": " (hsa:9734);  (R-HSA-2122947);  (R-HSA-2644606);  (R-HSA-2894862);  (R-HSA-350054);  (R-HSA-9976102)",
        "pathway_count": 6,
        "publication_count": 129,
        "publication_id_list": "10206645;10487760;10487761;10523670;10655483;10713164;10879540;10882063;10964718;11006133;11044625;11112321;11237011;11461910;11535832;11585921;11740940;12032081;12050117;12209127;12354787;12374742;12391150;12530964;12590135;12706107;14980219;15107403;15546612;15574878;15760269;15824097;15829515;16093323;16256737;16530044;16530045;16611996;16738328;16751179;17003037;17114293;17157496;17360565;17401372;17646408;17646409;18043734;18077452;18094723;18296446;18374649;18824583;18824585;19151708;19524514;19690332;19726682;20188095;20972443;21248752;22865920;24714562;25576301;25645385;26154972;26728094;26992070;27397612;27600516;27846572;27920218;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29557506;29632046;29632711;30315122;30379171;30429286;30524438;31154438;31222486;31844290;31848261;31998317;32157095;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33392160;33592498;33968037;34171305;34357683;34509645;34750192;34932366;35051231;35580925;36010968;36284347;38218381;38421101;38460370;38491522;38528189;7566092;7588063;8001118;8649374;8687460;9244301;9315665;9462510;9604939;9620803;9651681;9694793;9819428",
        "class_list": "",
        "function": "Endothelial beta-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9. Publication Status: Online-Only, [RefSeq, PubMed]; HDAC9 inhibition reduces skeletal muscle atrophy and enhances regeneration in mice with cigarette smoke-induced COPD., [RefSeq, PubMed]; HDAC9-mediated calmodulin deacetylation induces memory impairment in Alzheimer's disease., [RefSeq, PubMed]; Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection., [RefSeq, PubMed]; Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]; Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes. Publication Status: Online-Only, [RefSeq, PubMed]; Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter., [UniProtKB]; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7E2F3;B7Z4I4;B7Z917;B7Z928;B7Z940;C9JS87;E7EX34;F8W9E0;O94845;O95028;Q2M2R6;Q86SL1;Q86US3",
        "ec_number_list": "2.3.2.-;3.5.1.-;3.5.1.98;2.1.1.-;2.1.1.364;2.3.2.27;2.3.1.48;2.3.1.-;2.3.1.57;3.5.1.48;3.5.1.62",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0005080 protein kinase C binding;GO:0004407 histone deacetylase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0035097 histone methyltransferase complex",
        "go_biological_process": "GO:0048742 regulation of skeletal muscle fiber development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response;GO:0007507 heart development",
        "synthesized_glycan_count": 0,
        "hit_score": 13.2,
        "record_id": "Q9UKV0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P23381-1",
        "uniprot_id": "SYWC_HUMAN",
        "mass": 53165.0,
        "length": 471,
        "protein_name": "Tryptophan--tRNA ligase, cytoplasmic",
        "gene_name": "WARS1",
        "organism": "Human",
        "refseq_name": "tryptophan--tRNA ligase, cytoplasmic isoform a",
        "refseq_ac": "NP_004175",
        "gene_names_uniprotkb": "WARS1; IFI53; WARS; WRS",
        "gene_names_refseq": "GAMMA-2; HMN9; HMND9; IFI53; IFP53; NEDMSBA; WARS1; WARS",
        "protein_names_uniprotkb": "Tryptophan--tRNA ligase, cytoplasmic; 6.1.1.2; IFP53; Interferon-induced protein 53; TrpRS; Tryptophanyl-tRNA synthetase; hWRS",
        "protein_names_refseq": "epididymis secretory sperm binding protein; hWRS; interferon-induced protein 53; trpRS; tryptophan tRNA ligase 1, cytoplasmic; tryptophan--tRNA ligase, cytoplasmic isoform a; tryptophan--tRNA ligase, cytoplasmic",
        "tax_id": 9606,
        "disease": "autosomal dominant distal hereditary motor neuronopathy 9 (Disease Ontology:DOID:0111212); neurodevelopmental disorder with microcephaly and speech delay, with or without brain abnormalities (MONDO:MONDO:0957218)",
        "pathway": " (hsa:7453);  (R-HSA-379716)",
        "pathway_count": 2,
        "publication_count": 133,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11347887;11714285;11773625;11773626;11829477;11858721;12690580;1286667;1373391;14630953;14660560;14671330;14978097;1537332;15565337;15628863;16055448;16083285;16408927;16429158;16906134;16959974;1761529;1763065;1765274;18669648;19608861;19913117;20068231;22223895;23186163;24366607;24714562;24715725;25502872;25576301;25645385;25892735;26375851;26728094;26758079;27090790;27452731;27600516;27920218;28218747;28228285;28369220;28649982;28832583;28855257;28904123;29242379;29437277;29493099;29508533;29557506;29632711;29769354;29786170;30315122;30410026;30484775;30573663;30833945;31020640;31069783;31154438;31222486;31321409;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32938616;32983136;33091337;33214551;33298915;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34357683;34509645;34585293;34725712;35051231;35154160;35251023;35318648;35561310;35580925;35790048;35815345;36215666;36241641;36284347;37567323;37895133;38177528;38247871;38665916;40914422;4130389;6022858;656444;7118399;7654687;7685728;7814400;8052601;8078941;8188258;8428657;8449960;8496617;8724762;9278442;9421509;9431993",
        "class_list": "",
        "function": "Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp)., [UniProtKB, PubMed, PubMed, PubMed]; Exploring the role of tryptophanyl-tRNA synthetase and associations with inflammatory markers and clinical outcomes in COVID-19 patients: A case-control study., [RefSeq, PubMed]; Has an angiostatic activity., [UniProtKB, PubMed, PubMed]; Has no angiostatic activity., [UniProtKB, PubMed, PubMed]; Highly secreted tryptophanyl tRNA synthetase 1 as a potential theranostic target for hypercytokinemic severe sepsis. Erratum:[EMBO Mol Med. 2024 Mar;16(3):665. doi: 10.1038/s44321-024-00030-4. PMID: 38316935], [RefSeq, PubMed]; Possesses an angiostatic activity but has no aminoacylation activity (PubMed:11773625, PubMed:11773626, PubMed:14630953). Inhibits fluid shear stress-activated responses of endothelial cells (PubMed:14630953). Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (PubMed:14630953)., [UniProtKB, PubMed, PubMed, PubMed]; Tryptophan-Starved Human Cells Overexpressing Tryptophanyl-tRNA Synthetase Enhance High-Affinity Tryptophan Uptake via Enzymatic Production of Tryptophanyl-AMP. Publication Status: Online-Only, [RefSeq, PubMed]; Tryptophanyl-Transfer RNA Synthetase Is Involved in a Negative Feedback Loop Mitigating Interferon-gamma-Induced Gene Expression. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NGN1;A6NID3;P78535;Q502Y0;Q53XB6;Q9UDI5;Q9UDL3",
        "ec_number_list": "6.1.1.2",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0006412 translation;GO:0045765 regulation of angiogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 13.8,
        "record_id": "P23381-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y276-1",
        "uniprot_id": "BCS1_HUMAN",
        "mass": 47534.0,
        "length": 419,
        "protein_name": "Mitochondrial chaperone BCS1",
        "gene_name": "BCS1L",
        "organism": "Human",
        "refseq_name": "mitochondrial chaperone BCS1 isoform a",
        "refseq_ac": "NP_001073335",
        "gene_names_uniprotkb": "BCS1L; BCS1",
        "gene_names_refseq": "BCS1L; BCS1; BCS; BJS; FLNMS; GRACILE; Hs.6719; MC3DN1; PTD; h-BCS1; h-BCS",
        "protein_names_uniprotkb": "Mitochondrial chaperone BCS1; 3.6.1.-; BCS1-like protein; h-BCS1",
        "protein_names_refseq": "BC1 (ubiquinol-cytochrome c reductase) synthesis-like; BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; BCS1-like protein; mitochondrial chaperone BCS1 isoform a; mitochondrial chaperone BCS1; mitochondrial complex III assembly",
        "tax_id": 9606,
        "disease": "Bjornstad syndrome (Disease Ontology:DOID:0050677); mitochondrial complex III deficiency nuclear type 1 (Disease Ontology:DOID:0080111); GRACILE syndrome (Disease Ontology:DOID:0111455)",
        "pathway": " (hsa:617);  (R-HSA-1268020);  (R-HSA-9865881)",
        "pathway_count": 3,
        "publication_count": 80,
        "publication_id_list": "11237011;11528392;12215968;12910490;14726512;15254020;15644312;15683237;16185709;16849325;17314340;17403714;17510655;18174896;18628306;18678864;19162478;19409522;19453276;19767391;19962426;20593814;21278747;21750375;22991165;23041349;23168492;23186163;23481700;23597483;23811401;24172246;24385928;25008109;25315652;25418920;25605331;26154972;26375851;26697887;26929215;26992070;27726376;27846572;27920218;28228285;28380382;28510447;28673544;28832583;28844695;28904123;29243944;29393594;29632046;30315122;31222486;31530632;31844290;32161166;32265295;32387766;32488085;32502341;32897882;32929120;32938616;32983136;33912179;33968037;34357683;34561969;34650211;34662929;34969438;35051231;38423010;38821922;40914422;9878253",
        "class_list": "",
        "function": "BCS1L mutations produce Fanconi syndrome with developmental disability., [RefSeq, PubMed]; Chaperone necessary for the incorporation of Rieske iron-sulfur protein UQCRFS1 into the mitochondrial respiratory chain complex III (PubMed:11528392, PubMed:9878253). Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (PubMed:18628306)., [UniProtKB, PubMed, PubMed, PubMed]; Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate. Publication Status: Online-Only, [RefSeq, PubMed]; Expanding the phenotypic spectrum of BCS1L-related mitochondrial disease., [RefSeq, PubMed]; This gene encodes a homolog of the S. cerevisiae bcs1 protein which is involved in the assembly of complex III of the mitochondrial respiratory chain. The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Several alternatively spliced transcripts encoding two different isoforms have been described. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KTW9;Q7Z2V7",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.3.3.1;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;7.1.2.2;7.1.1.8;5.6.1.7;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;4.2.1.3;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III;GO:0031966 mitochondrial membrane",
        "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0007005 mitochondrion organization;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0032979 protein insertion into mitochondrial inner membrane from matrix",
        "synthesized_glycan_count": 0,
        "hit_score": 8.3,
        "record_id": "Q9Y276-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UFG5-1",
        "uniprot_id": "CS025_HUMAN",
        "mass": 12878.0,
        "length": 118,
        "protein_name": "UPF0449 protein C19orf25",
        "gene_name": "C19orf25",
        "organism": "Human",
        "refseq_name": "UPF0449 protein C19orf25",
        "refseq_ac": "NP_689695",
        "gene_names_uniprotkb": "C19orf25",
        "gene_names_refseq": "C19orf25",
        "protein_names_uniprotkb": "UPF0449 protein C19orf25",
        "protein_names_refseq": "UPF0449 protein C19orf25",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:148223)",
        "pathway_count": 1,
        "publication_count": 28,
        "publication_id_list": "11237011;16303743;19913121;20628086;23481700;25418920;25576301;25880248;26375851;27920218;28832583;29242379;29393594;29632046;29632711;30315122;30410026;31844290;32488085;32502341;32938616;32983136;33298915;33717175;33912179;35580925;36010968;36241641",
        "class_list": "",
        "function": "Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KQN6;Q8N9R7;Q8WV94",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q9UFG5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z3B3-1",
        "uniprot_id": "KANL1_HUMAN",
        "mass": 120966.0,
        "length": 1105,
        "protein_name": "KAT8 regulatory NSL complex subunit 1",
        "gene_name": "KANSL1",
        "organism": "Human",
        "refseq_name": "KAT8 regulatory NSL complex subunit 1 isoform 2",
        "refseq_ac": "NP_001180394",
        "gene_names_uniprotkb": "KANSL1; CENP-36; KIAA1267; MSL1V1; NSL1",
        "gene_names_refseq": "C17DELq21.31; CENP-36; DEL17Q21.31; KANSL1; KDVS; KIAA1267; MSL1v1; NSL1; hMSL1v1",
        "protein_names_uniprotkb": "KAT8 regulatory NSL complex subunit 1; MLL1/MLL complex subunit KANSL1; MSL1 homolog 1; NSL complex protein NSL1; Non-specific lethal 1 homolog; hMSL1v1",
        "protein_names_refseq": "KAT8 regulatory NSL complex subunit 1 isoform 2; MLL1/MLL complex subunit KANSL1; MSL1 homolog 1; NSL complex protein NSL1; centromere protein 36; male-specific lethal 1 homolog; non-specific lethal 1 homolog",
        "tax_id": 9606,
        "disease": "Koolen de Vries syndrome (Disease Ontology:DOID:0050880); intellectual disability (Disease Ontology:DOID:1059)",
        "pathway": " (hsa:284058);  (R-HSA-3214847);  (R-HSA-9772755)",
        "pathway_count": 3,
        "publication_count": 129,
        "publication_id_list": "10786633;10821277;11237011;11641718;12393701;12482972;12670868;14636557;14992727;15199122;15313887;15960975;16227571;16239140;16387653;16543150;16829959;16878130;16892064;17081983;17355966;17500065;17612494;17671196;17925232;17998332;18220336;18381289;18452278;18598942;18623064;18669648;18829457;18829459;18838386;18838538;19103755;19124460;19187761;19187765;19556245;19608861;19651622;19664995;19690332;19691289;20018852;20058876;20068231;20575550;20620954;20716525;20813266;20961854;21106533;21124902;21131905;21135039;21217699;21220120;22266653;22327296;22544363;22544367;22547026;22652693;22665483;23186163;23481700;23508102;23995757;24244196;24275569;24368734;24680668;25561738;25576301;25593305;26243146;26324722;26424144;26886794;27563068;27600516;27698142;27760318;27768893;27862975;27920218;28182322;28218747;28398509;28514659;28832583;28834231;29138278;29242379;29508533;29632711;29786170;29897600;29937342;30379171;30429286;30524438;31092671;31400120;31485071;31544921;31848261;33657400;34012049;34019948;34933446;35033534;35132862;35190547;35254053;35439434;35494241;35575789;37938771;38282074;39302247;40307207;40596516;9427644;9558366;9880483",
        "class_list": "",
        "function": "A new blood DNA methylation signature for Koolen-de Vries syndrome: Classification of missense KANSL1 variants and comparison to fibroblast cells. Erratum:[Eur J Hum Genet. 2024 Mar;32(3):366. doi: 10.1038/s41431-024-01561-7. PMID: 38355964], [RefSeq, PubMed]; Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Recurrent KAT6B/A::KANSL1 Fusions Characterize a Potentially Aggressive Uterine Sarcoma Morphologically Overlapping With Low-grade Endometrial Stromal Sarcoma., [RefSeq, PubMed]; This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The encoded protein has been implicated in a variety of cellular processes including enhancer regulation, cell proliferation, and mitosis. Mutations in this gene are associated with Koolen-de Vries Syndrome. [provided by RefSeq, May 2022]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 52,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5E4;B3KT49;I3L4J3;Q6AW85;Q8IYH1;Q9BRH0;Q9NTE7;Q9UFT0;Q9ULF3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0035035 histone acetyltransferase binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005874 microtubule",
        "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:1903108 regulation of mitochondrial transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 13.2,
        "record_id": "Q7Z3B3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P30626-1",
        "uniprot_id": "SORCN_HUMAN",
        "mass": 21676.0,
        "length": 198,
        "protein_name": "Sorcin",
        "gene_name": "SRI",
        "organism": "Human",
        "refseq_name": "sorcin isoform D",
        "refseq_ac": "NP_001243821",
        "gene_names_uniprotkb": "SRI",
        "gene_names_refseq": "CP-22; CP22; SCN; SRI; V19",
        "protein_names_uniprotkb": "Sorcin; 22 kDa protein; CP-22; CP22; V19",
        "protein_names_refseq": "22 kDa protein; H_RG167B05.1; calcium binding protein amplified in mutlidrug-resistant cells; sorcin isoform D",
        "tax_id": 9606,
        "disease": "congestive heart failure (Disease Ontology:DOID:6000)",
        "pathway": " (hsa:6717);  (R-HSA-2672351);  (R-HSA-418359);  (R-HSA-425561);  (R-HSA-5578775);  (R-HSA-936837)",
        "pathway_count": 6,
        "publication_count": 207,
        "publication_id_list": "10220561;10401004;10484781;10564087;10615129;10642508;10662833;10720933;10767338;10767424;10830164;10831588;10913253;11062458;11182090;11237011;11294880;11588175;11687798;11714909;11734858;11842292;11904445;11904675;11956057;12119109;12379639;12393854;12406570;12804766;12832055;1286667;12907679;12953268;1374913;1379744;14584882;14625281;14634667;15010458;15044642;15060069;15147738;15174025;15260953;15318163;15504734;15505377;15598648;15754088;15831496;15916532;15919184;15919655;15925480;16182249;16219661;16341674;16357253;1656976;16700898;16754674;16813530;16849430;16850186;1693919;17224452;17357072;17381423;17448995;17486119;17699613;17881003;18000046;18063579;18166528;18310267;18400985;18449189;18508966;18662336;18723824;18724360;18995841;19153159;19278978;19307298;19345671;19380724;19387438;19620632;19751721;19808995;19878721;19953639;20298697;20388639;20388710;20466723;20525693;20538786;21040849;21108950;21527911;2160952;21984732;22002868;22186024;22210847;2226863;22427649;22707725;22773952;22946059;22972900;2298749;23112050;23196729;2321095;23362265;23549614;23610579;23616951;2430951;24392018;24427308;2477373;2536303;2559024;25994790;26359375;26421717;26562072;26719254;26992070;27067231;27600516;27846572;27920218;28063628;28071645;28154142;28228285;2838329;2844759;28645727;28790369;28832583;29242379;29393594;2953725;29557506;29632046;29632711;29789417;30779550;31844290;32157095;32350084;32938616;33060591;33214551;33592498;33717175;33960419;34019948;34163033;34205207;37938771;38536659;38665916;5961668;6328127;6832622;7588753;7626145;7665160;7702581;7795595;7873602;7929371;8021246;8041726;8045293;8112288;8298639;8383669;8490646;8490659;8533761;8544406;8561500;8626462;8798450;8809036;8918259;9037075;9147644;9307043;9346285;9395096;9571199;9662395;9700209;9719863;9744806;9856482",
        "class_list": "",
        "function": "A novel homeostatic loop of sorcin drives paclitaxel-resistance and malignant progression via Smad4/ZEB1/miR-142-5p in human ovarian cancer., [RefSeq, PubMed]; Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels., [UniProtKB, PubMed]; Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity. Publication Status: Online-Only, [RefSeq, PubMed]; Sorcin is an early marker of neurodegeneration, Ca(2+) dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases. Publication Status: Online-Only, [RefSeq, PubMed]; Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway., [RefSeq, PubMed]; The Ca(2+) -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6., [RefSeq, PubMed]; This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MTH6;B4DKK2;D6W5Q0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0005246 calcium channel regulator activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0051924 regulation of calcium ion transport;GO:0055118 negative regulation of cardiac muscle contraction;GO:0010459 negative regulation of heart rate;GO:0051281 positive regulation of release of sequestered calcium ion into cytosol",
        "synthesized_glycan_count": 0,
        "hit_score": 21.0,
        "record_id": "P30626-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NZQ3-1",
        "uniprot_id": "SPN90_HUMAN",
        "mass": 78960.0,
        "length": 722,
        "protein_name": "NCK-interacting protein with SH3 domain",
        "gene_name": "NCKIPSD",
        "organism": "Human",
        "refseq_name": "NCK-interacting protein with SH3 domain isoform 1",
        "refseq_ac": "NP_057537",
        "gene_names_uniprotkb": "NCKIPSD; AF3P21; SPIN90",
        "gene_names_refseq": "AF3P21; DIP1; DIP; NCKIPSD; ORF1; SPIN90; VIP54; WASLBP; WISH",
        "protein_names_uniprotkb": "NCK-interacting protein with SH3 domain; 54 kDa VacA-interacting protein; 54 kDa vimentin-interacting protein; 90 kDa SH3 protein interacting with Nck; AF3p21; DIP-1; Dia-interacting protein 1; Diaphanous protein-interacting protein; SH3 adapter protein SPIN90; VIP54; WASP-interacting SH3-domain protein; WISH; Wiskott-Aldrich syndrome protein-interacting protein",
        "protein_names_refseq": "54 kDa VacA-interacting protein; 54 kDa vimentin-interacting protein; 90 kDa SH3 protein interacting with Nck; NCK-interacting protein with SH3 domain isoform 1; SH3 adapter protein SPIN90; SH3 protein interacting with Nck, 90 kDa; WASP-interacting SH3-domain protein; dia interacting protein; dia-interacting protein 1; diaphanous protein interacting protein; wiskott-Aldrich syndrome protein-interacting protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51517);  (R-HSA-2029482);  (R-HSA-5663213);  (R-HSA-9664422)",
        "pathway_count": 4,
        "publication_count": 104,
        "publication_id_list": "10219243;10496324;10559936;10619843;10648423;10724160;10781580;10878810;10995437;11157975;11231582;11237011;11241789;11276226;11278486;11278500;11329366;11340081;11509578;11553796;11747816;11804587;11829459;11854399;12055636;12105426;12189515;12213210;12235133;12743368;1314888;14676198;15040784;15095401;15452139;15657136;16262445;16546099;16641196;16702231;16880808;17188549;17202194;17308335;18070890;18088087;18391171;19741094;19807924;19955216;21037092;21419341;22419821;23186163;23342115;23481700;23675550;23765104;24715725;2474607;25576301;26154972;26992070;27920218;28228285;28657654;28832583;28860189;28904123;29242379;29393594;29508533;29557506;29632046;29769354;29786170;30484775;31844290;32157095;32265295;32350084;32387766;32488085;32897882;32938616;33141586;33968037;34019948;34171305;34509645;35051231;36010968;36581221;39302247;39534244;7848918;8809042;8986718;9600938;9705280;9799231;9843499;9883880;9885284",
        "class_list": "",
        "function": "Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis., [UniProtKB, PubMed]; The protein encoded by this gene contains a nuclear localization signal. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation This protein is involved in the formation and maintenance of dendritic spines, and modulates synaptic activity in neurons. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2019]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DFL5;Q6GU34;Q6SPF3;Q8TC10;Q9UGM8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0008092 cytoskeletal protein binding;GO:0071933 Arp2/3 complex binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005882 intermediate filament;GO:0098794 postsynapse",
        "go_biological_process": "GO:0006897 endocytosis;GO:0010976 positive regulation of neuron projection development;GO:0007010 cytoskeleton organization;GO:0150052 regulation of postsynapse assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q9NZQ3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IYX8-1",
        "uniprot_id": "CE57L_HUMAN",
        "mass": 53649.0,
        "length": 460,
        "protein_name": "Centrosomal protein CEP57L1",
        "gene_name": "CEP57L1",
        "organism": "Human",
        "refseq_name": "centrosomal protein CEP57L1 isoform 1",
        "refseq_ac": "NP_001077004",
        "gene_names_uniprotkb": "CEP57L1; C6orf182; CEP57R",
        "gene_names_refseq": "C6orf182; CEP57L1; bA487F23.2; cep57R",
        "protein_names_uniprotkb": "Centrosomal protein CEP57L1; Centrosomal protein 57kDa-like protein 1; Centrosomal protein of 57 kDa-related protein; Cep57-related protein; Cep57R",
        "protein_names_refseq": "centrosomal protein 57kDa-like 1; centrosomal protein 57kDa-like protein 1; centrosomal protein CEP57L1 isoform 1; centrosomal protein CEP57L1; centrosomal protein of 57 kDa-related protein; cep57-related protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285753)",
        "pathway_count": 1,
        "publication_count": 54,
        "publication_id_list": "11237011;14654843;18294141;20166139;23186163;23481700;25576301;25892735;26992070;27600516;28063628;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29632046;29769354;30315122;30524438;30779550;30833945;31154438;31530632;31844290;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33492359;33537174;33592498;33717175;33912179;33968037;33981976;34171305;34405274;34509645;34932366;35051231;35318648;36284347;36581221;37938771",
        "class_list": "",
        "function": "Centrosomal protein which may be required for microtubule attachment to centrosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G5E992",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0043015 gamma-tubulin binding",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q8IYX8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UBL6-1",
        "uniprot_id": "CPNE7_HUMAN",
        "mass": 70294.0,
        "length": 633,
        "protein_name": "Copine-7",
        "gene_name": "CPNE7",
        "organism": "Human",
        "refseq_name": "copine-7 isoform b",
        "refseq_ac": "NP_055242",
        "gene_names_uniprotkb": "CPNE7",
        "gene_names_refseq": "CPNE7",
        "protein_names_uniprotkb": "Copine-7; Copine VII",
        "protein_names_refseq": "copine VII; copine-7 isoform b",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27132);  (R-HSA-1483206)",
        "pathway_count": 2,
        "publication_count": 33,
        "publication_id_list": "10534407;11237011;1168700;12440769;12949241;15939762;18452278;20068231;21087455;22284826;24338473;25002142;25453951;25576301;26755581;26992070;27846572;28228285;28904123;30315122;31844290;32157095;32387766;33912179;33981976;35051231;35580925;36241641;37938771;38069026;38526029;38838015;9430674",
        "class_list": "",
        "function": "Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes., [UniProtKB, UniProtKB]; Depletion of CPNE7 sensitizes colorectal cancer to 5-fluorouracil by downregulating ATG9B expression., [RefSeq, PubMed]; The Role of CPNE7 (Copine-7) in Colorectal Cancer Prognosis and Metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest Cpne7 is a diffusible signaling molecule that is secreted by preameloblasts, and regulates the differentiation of mesenchymal cells of dental or non-dental origin into odontoblasts., [RefSeq, PubMed]; This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains and one von Willebrand factor A domain. The encoded protein may be involved in membrane trafficking. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0043495 protein-membrane adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0046474 glycerophospholipid biosynthetic process;GO:0071277 cellular response to calcium ion",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q9UBL6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14997-1",
        "uniprot_id": "PSME4_HUMAN",
        "mass": 211334.0,
        "length": 1843,
        "protein_name": "Proteasome activator complex subunit 4",
        "gene_name": "PSME4",
        "organism": "Human",
        "refseq_name": "proteasome activator complex subunit 4",
        "refseq_ac": "NP_055429",
        "gene_names_uniprotkb": "PSME4; BLM10; KIAA0077",
        "gene_names_refseq": "Blm10; PA200; PSME4; hBlm10",
        "protein_names_uniprotkb": "Proteasome activator complex subunit 4; Blm10; Proteasome activator PA200; Protein BLM10 homolog; hBlm10",
        "protein_names_refseq": "proteasome (prosome, macropain) activator subunit 4; proteasome activator 200 kDa; proteasome activator PA200; proteasome activator complex subunit 4; protein BLM10 homolog",
        "tax_id": 9606,
        "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545)",
        "pathway": " (hsa:23198);  (R-HSA-9907900)",
        "pathway_count": 2,
        "publication_count": 117,
        "publication_id_list": "10973495;11237011;12093752;15831487;16251969;16990800;17189198;17323924;17540904;17948026;18669648;18845680;19490896;19664994;20068231;20471946;22424782;22550082;23186163;23481700;23495936;23706739;24366607;24714562;24715725;25418920;25505266;25576301;25645385;25880248;25892735;26154972;26375851;26811146;26929215;26992070;27600516;27846572;27862975;27869121;27920218;28063628;28218747;28228285;28263418;28442575;28510447;28598414;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30379171;30410026;30429286;30524438;30833945;31092671;31217245;31492838;31548259;31844290;32157095;32161166;32265295;32350084;32357974;32368861;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33233776;33298915;33392160;33537174;33562813;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34561969;35008409;35051231;35318648;35561310;35580925;36010968;36215666;36241641;37217651;37217939;37938771",
        "class_list": "",
        "function": "Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing. Publication Status: Online-Only, [RefSeq, PubMed]; Identified a novel 200 kDa nuclear protein that activates the proteasome; findings implicate PA200 in DNA repair, possibly by recruiting proteasomes to double strand breaks, [RefSeq, PubMed]; The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin. Publication Status: Online-Only, [RefSeq, PubMed]; The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells., [RefSeq, PubMed]; The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q1XBG4;Q1XBG5;Q1XBG6;Q2M1Z0;Q6IPR2;Q86XF8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0016504 peptidase activator activity;GO:0070628 proteasome binding",
        "go_cellular_component": "GO:1990111 spermatoproteasome complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0006281 DNA repair;GO:0030317 flagellated sperm motility;GO:0006974 DNA damage response;GO:0010499 proteasomal ubiquitin-independent protein catabolic process;GO:0035092 sperm DNA condensation",
        "synthesized_glycan_count": 0,
        "hit_score": 12.1,
        "record_id": "Q14997-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q07866-1",
        "uniprot_id": "KLC1_HUMAN",
        "mass": 65310.0,
        "length": 573,
        "protein_name": "Kinesin light chain 1",
        "gene_name": "KLC1",
        "organism": "Human",
        "refseq_name": "kinesin light chain 1 isoform 3",
        "refseq_ac": "NP_001123579",
        "gene_names_uniprotkb": "KLC1; KLC; KNS2",
        "gene_names_refseq": "KLC1; KLC; KNS2A; KNS2",
        "protein_names_uniprotkb": "Kinesin light chain 1; KLC 1",
        "protein_names_refseq": "kinesin 2 60/70kDa; kinesin light chain 1 isoform 3; medulloblastoma antigen MU-MB-2.50",
        "tax_id": 9606,
        "disease": "Alzheimer's disease 1 (Disease Ontology:DOID:0080348); Alzheimer's disease (Disease Ontology:DOID:10652); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378)",
        "pathway": " (hsa:3831);  (R-HSA-2132295);  (R-HSA-5625970);  (R-HSA-6811434);  (R-HSA-9725370);  (R-HSA-983189)",
        "pathway_count": 6,
        "publication_count": 356,
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        "class_list": "",
        "function": "Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named 'kinesin 2', this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]; Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing., [RefSeq, PubMed]; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity)., [UniProtKB, UniProtKB, PubMed]; Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 10,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NF62;F8VTM4;Q7RTM2;Q7RTM3;Q7RTM5;Q7RTP9;Q7RTQ3;Q7RTQ5;Q7RTQ6;Q86SF5;Q86TF5;Q86V74;Q86V75;Q86V76;Q86V77;Q86V78;Q86V79;Q96H62",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019894 kinesin binding;GO:0003774 cytoskeletal motor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016020 membrane;GO:0030426 growth cone",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007018 microtubule-based movement;GO:0035617 stress granule disassembly",
        "synthesized_glycan_count": 0,
        "hit_score": 35.7,
        "record_id": "Q07866-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UB35-1",
        "uniprot_id": "C1TM_HUMAN",
        "mass": 105790.0,
        "length": 978,
        "protein_name": "Monofunctional C1-tetrahydrofolate synthase, mitochondrial",
        "gene_name": "MTHFD1L",
        "organism": "Human",
        "refseq_name": "monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 1 precursor",
        "refseq_ac": "NP_001229696",
        "gene_names_uniprotkb": "MTHFD1L; FTHFSDC1",
        "gene_names_refseq": "FTHFSDC1; MTC1THFS; MTHFD1L; dJ292B18.2",
        "protein_names_uniprotkb": "Monofunctional C1-tetrahydrofolate synthase, mitochondrial; 6.3.4.3; Formyltetrahydrofolate synthetase",
        "protein_names_refseq": "10-formyl-THF synthetase; formyltetrahydrofolate synthetase domain containing 1; monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 1 precursor; monofunctional C1-tetrahydrofolate synthase, mitochondrial",
        "tax_id": 9606,
        "disease": "neural tube defect (Disease Ontology:DOID:0080074)",
        "pathway": " (hsa:25902);  (R-HSA-196757)",
        "pathway_count": 2,
        "publication_count": 93,
        "publication_id_list": "10091649;10347183;10978331;11237011;12937168;15013446;15068241;16171773;16959974;17129779;17308042;17962486;19424049;19608861;19664995;19948730;20068231;20498374;21163947;21238436;21876188;2248959;23186163;23301498;23409799;23481700;23934049;24733394;25418920;2605182;26154972;26992070;27090790;27452731;27600516;28218747;28228285;28832583;28904123;29242379;29557506;30192525;30315122;30379171;3053686;30833945;31363079;31530632;31844290;32157095;32161166;32387766;32423175;32456526;32488085;32658475;32938616;32983136;33053560;33141586;33163492;33298915;33392160;33592498;33912179;33936100;33968037;33981976;34087483;34357683;34509645;34561969;34725712;34908119;35051231;35083852;35251023;35459186;36010968;36215666;36241641;3801490;38665916;3871768;40596516;4066659;6323448;7726158;7852378;8218174;8522195;8662720;9753690",
        "class_list": "",
        "function": "Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Gene encodes the mitochondrial isozyme of C1-tetrahydrofolate (THF) synthase, a monofunctional enzyme containing formyl-THF synthetase activity., [RefSeq, PubMed]; Integrative analysis reveals methylenetetrahydrofolate dehydrogenase 1-like as an independent shared diagnostic and prognostic biomarker in five different human cancers., [RefSeq, PubMed]; MTHFD1L as a folate cycle enzyme correlates with prognostic outcome and its knockdown impairs cell invasive behaviors in osteosarcoma via mediating the AKT/mTOR pathway., [RefSeq, PubMed]; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Mitochondrial C1-tetrahydrofolate synthase gene structure and tissue distribution, [RefSeq, PubMed]; Overexpression of C1-tetrahydrofolate synthase in fetal Down syndrome brain at the early second trimester may indicate abnormal folate metabolism and may reflect folate deficiency., [RefSeq, PubMed]; Results together with the limitations of the original studies indicate that the reported associations between the MTHFD1L and FOPNL loci and MM survival are false positives due to a winner's curse effect. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2TBF3;Q8WVW0;Q96HG8;Q9H789;Q9UFU8",
        "ec_number_list": "6.3.4.3;1.5.1.5;3.5.4.9",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0004329 formate-tetrahydrofolate ligase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0001843 neural tube closure;GO:0006760 folic acid-containing compound metabolic process;GO:0009257 10-formyltetrahydrofolate biosynthetic process;GO:0015942 formate metabolic process;GO:0035999 tetrahydrofolate interconversion",
        "synthesized_glycan_count": 0,
        "hit_score": 9.7,
        "record_id": "Q6UB35-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86UP2-1",
        "uniprot_id": "KTN1_HUMAN",
        "mass": 156275.0,
        "length": 1357,
        "protein_name": "Kinectin",
        "gene_name": "KTN1",
        "organism": "Human",
        "refseq_name": "kinectin isoform a",
        "refseq_ac": "NP_001072989",
        "gene_names_uniprotkb": "KTN1; CG1; KIAA0004",
        "gene_names_refseq": "CG1; KNT; KTN1; MU-RMS-40.19",
        "protein_names_uniprotkb": "Kinectin; CG-1 antigen; Kinesin receptor",
        "protein_names_refseq": "CG-1 antigen; kinectin isoform a; kinesin receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3895);  (R-HSA-381426);  (R-HSA-5625970);  (R-HSA-8957275);  (R-HSA-8980692);  (R-HSA-9013148);  (R-HSA-9013149);  (R-HSA-9013408);  (R-HSA-9696264);  (R-HSA-9696270)",
        "pathway_count": 10,
        "publication_count": 502,
        "publication_id_list": "10.1101/2023.09.13.557529;10026136;10037681;10077652;10218588;10232922;10464238;10490598;10508610;10512690;10523665;10523675;10526156;10559246;10579713;10614670;10619026;10652265;10664463;10681634;10699171;10699464;10724160;10810289;10873388;10873802;10898936;10912521;10913441;10951195;10958683;10990447;11007481;11058585;11085924;11149925;11158056;11207612;11237011;11250653;11264294;11306516;11316783;11373293;11396949;11431473;11432776;11522292;11584276;11606061;11606631;11672528;11680691;11689693;11696321;11704860;11707441;11739083;11751371;11756552;11773441;11788658;11803464;11804587;11804589;11804590;11864571;11884391;11912491;11933159;11940653;11948177;11961559;11967128;11973345;12071859;12093360;12096337;12172552;12177196;12195014;12221077;12221096;12241545;12244061;12351724;12376551;12379487;12432077;12464619;12466191;12531887;12546821;12547822;12650940;12665586;12773384;12810533;12842009;12857875;12860998;12877655;12904166;12907671;12923183;12947009;1370451;1383255;14506234;14512443;14514689;1464587;14675773;14718541;14732713;15023524;15033976;15064355;15107133;15126567;15133129;15147912;15157669;15260990;15302923;15304341;15308688;15339924;15342493;15469690;15485661;15485880;15507211;15525596;15579468;15601624;15611138;15642270;15728722;15738000;15850391;15858067;15866170;15897194;16002401;16112081;16116428;16184169;16217026;16243036;16339170;16467373;16473593;16481321;16492808;16507994;16519628;16630611;16636067;16702231;16714282;16762923;16776779;16777452;16777849;16862148;16896804;16914516;16959974;16968698;17027967;17047378;17064668;17077126;17081983;17145773;17196961;17214551;17244649;17249697;17312271;17562871;17583407;17599059;17702745;17765681;17804252;17932950;17942708;17976533;17985932;18006505;18045877;18056264;18158243;18218625;18249095;18347018;18363964;18396277;18426980;18452278;18578522;18653540;18669648;18691976;18707149;18767875;18786931;18829452;18835169;18838382;18929667;18996843;19007248;19136556;19269969;19413330;19494238;19581409;19605563;19635168;19651622;19673492;19691289;19713215;19934221;20030946;20068230;20068231;20101212;20166139;20400958;20460433;20591975;20628200;20660154;20679435;20810653;20811643;21148482;21351730;21406692;21454492;21542010;21565175;21613211;21621533;21685891;21699497;21730051;21865595;21936715;21989057;22004470;22096251;22298643;22305756;22407364;22461490;22475431;22571869;22608513;22673745;22734669;22911862;22970203;22992742;23186163;23200924;23209303;23255595;23288169;23406282;23434736;23481700;23572525;23707487;23718289;23870313;23940355;24086303;24128008;24259668;24275569;24335996;24352656;24366607;24584464;24659802;24690281;24714562;2476804;2479552;24859002;24933155;24960694;24996924;25024229;25211221;25418920;25428919;25576301;25645385;25704760;25721503;25795300;25862245;25888806;25892735;25963737;26091039;26129894;26154972;26299518;26371245;26375851;26529257;26598554;26728094;26887924;26969432;26992070;27096001;27117132;27145964;27216196;27481945;27555588;27566826;27600516;27713499;27798618;27806292;27846572;27862975;27920218;27932480;27986909;28028151;28063628;28112683;28114311;28196833;28218747;28228285;28514659;28584191;28825699;28832583;28834231;28855257;28860633;28904123;29089502;29146911;29242379;29314611;29358323;29382922;29393594;29493099;29557506;29632046;29632711;29786170;29789417;30061681;30315122;30410026;30429286;30524438;30853411;31105010;31217245;31844290;31871319;32157095;32203420;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33214551;33465208;33537174;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34229054;34357683;34405274;34509645;34932366;35051231;35138101;35251023;35561310;35580925;36010968;36284347;37074911;37217939;37938771;37992546;38448340;38665916;39302247;40596516;7476457;7479768;7512369;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7559638;7588299;7673236;7683646;7689487;7721814;7753201;7787243;7787244;7835339;8021274;8039706;8107774;8537347;8543060;8571126;8575822;8617235;8643598;8645157;8649376;8649427;8662891;8670801;8756646;8769096;8781553;8798539;8805223;8807639;8810315;8816443;8817670;8894645;8912005;8939998;8964575;8990121;8994827;9013646;9099726;9111050;9113980;9268338;9305890;9405671;9418861;9438849;9490638;9497316;9497324;9535835;9548756;9582072;9659915;9670022;9709957;9733769;9786878;9792683;9822598;9822605;9822636;9829970;9843499;9846874;9922210;9988689",
        "class_list": "",
        "function": "A genetic and transcriptomic assessment of the KTN1 gene in Parkinson's disease risk., [RefSeq, PubMed]; KTN1 mediated unfolded protein response protects keratinocytes from ionizing radiation-induced DNA damage., [RefSeq, PubMed]; Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin., [UniProtKB]; This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 0,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DZ88;Q13999;Q14707;Q15387;Q17RZ5;Q5GGW3;Q86W57",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0045296 cadherin binding;GO:0019894 kinesin binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0015031 protein transport;GO:0007018 microtubule-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 51.5,
        "record_id": "Q86UP2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60313-1",
        "uniprot_id": "OPA1_HUMAN",
        "mass": 111631.0,
        "length": 960,
        "protein_name": "Dynamin-like GTPase OPA1, mitochondrial",
        "gene_name": "OPA1",
        "organism": "Human",
        "refseq_name": "dynamin-like GTPase OPA1, mitochondrial isoform 1 preproprotein",
        "refseq_ac": "NP_056375",
        "gene_names_uniprotkb": "OPA1; KIAA0567",
        "gene_names_refseq": "BERHS; MGM1; MTDPS14A; MTDPS14B; MTDPS14; NPG; NTG; OPA1; largeG",
        "protein_names_uniprotkb": "Dynamin-like GTPase OPA1, mitochondrial; 3.6.5.5; Optic atrophy protein 1",
        "protein_names_refseq": "dynamin-like 120 kDa protein, mitochondrial; dynamin-like GTPase OPA1, mitochondrial isoform 1 preproprotein; dynamin-like GTPase OPA1, mitochondrial; dynamin-like guanosine triphosphatase; mitochondrial dynamin-like GTPase; optic atrophy 1 (autosomal dominant); optic atrophy protein 1",
        "tax_id": 9606,
        "disease": "mitochondrial DNA depletion syndrome 14 (Disease Ontology:DOID:0080336); dominant optic atrophy plus syndrome (Disease Ontology:DOID:0111340); optic atrophy 1 (Disease Ontology:DOID:0111441); Behr syndrome (Disease Ontology:DOID:0111580); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); transient cerebral ischemia (Disease Ontology:DOID:224); rhinitis (Disease Ontology:DOID:4483); schizophrenia (Disease Ontology:DOID:5419); optic atrophy (Disease Ontology:DOID:5723); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); chronic kidney disease (Disease Ontology:DOID:784); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); ocular hypertension (Disease Ontology:DOID:9282); steatotic liver disease (Disease Ontology:DOID:9452); mitochondrial dna depletion syndrome 14A (encephalomyopathic type) (MONDO:MONDO:0980967)",
        "pathway": " (hsa:4976);  (R-HSA-169911);  (R-HSA-9837999)",
        "pathway_count": 3,
        "publication_count": 164,
        "publication_id_list": "11017079;11017080;11237011;11440988;11440989;11810270;11923310;12036970;12042320;12198491;12566046;14623864;14961560;15104674;15144186;15522782;15531309;15870080;15948788;16115876;16240368;16513463;16617242;16778770;17101804;17297443;17579211;17615298;17709429;17924679;18065439;18158317;18195150;18204809;18360822;18452278;18691976;19001017;19319978;19325939;19608861;19841671;19969356;20038677;20112406;20185555;20843780;20974897;21081504;21112924;21364629;21636302;22262461;22382025;22710082;22857269;23201127;23387428;23401657;23931759;24315374;24520911;24616225;24715725;25012220;25146916;25505266;25576301;25880248;26154972;26504172;26561570;26811146;26923599;26992070;27452731;27495975;27496948;27600516;27642048;27846572;28377575;28396416;28510447;28628083;28746876;28832583;28904123;29242379;29301859;29437277;29493099;29557506;29932645;30120231;30315122;30429286;31092671;31154438;31217245;31327635;31695197;31844290;31922487;32157095;32228866;32245890;32350084;32357974;32379273;32387766;32488085;32502341;32567732;32897882;32938616;32983136;33130824;33141586;33237841;33257573;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34561969;34704252;34932366;34943861;35051231;35251023;35561310;35580925;35870450;36010968;36241641;36284347;36581221;36629048;37217939;37612504;37612506;37938771;38253038;39039850;39142278;39177028;39233737;39363032;40914422;7623837",
        "class_list": "",
        "function": "Characteristics of autosomal dominant WFS1-associated optic neuropathy and its comparability to OPA1-associated autosomal dominant optic atrophy. Publication Status: Online-Only, [RefSeq, PubMed]; Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion., [UniProtKB, PubMed]; Constitutes the soluble short form (S-OPA1) generated by cleavage by OMA1, which plays a central role in mitochondrial inner membrane fusion and cristae morphology (PubMed:31922487, PubMed:32228866, PubMed:32245890, PubMed:37612504, PubMed:37612506). The transmembrane long form (L-OPA1) and the S-OPA1 form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (PubMed:31922487, PubMed:32228866, PubMed:37612504, PubMed:37612506). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (PubMed:32228866, PubMed:37612504, PubMed:37612506). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (PubMed:37612504, PubMed:37612506). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (PubMed:28628083, PubMed:37612504, PubMed:37612506). Excess levels of S-OPA1 produced by cleavage by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, thereby inhibiting mitochondrial fusion (PubMed:20038677). Involved in mitochondrial safeguard in response to transient mitochondrial membrane depolarization by mediating flickering: cleavage by OMA1 leads to excess production of S-OPA1, preventing mitochondrial hyperfusion (By similarity). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (PubMed:32245890). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity). The equilibrium between L-OPA1 and S-OPA1 influences cristae shape and morphology: increased L-OPA1 levels promote cristae stacking and elongated mitochondria, while increased S-OPA1 levels correlated with irregular cristae packing and round mitochondria shape (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Constitutes the transmembrane long form (L-OPA1) that plays a central role in mitochondrial inner membrane fusion and cristae morphology (PubMed:31922487, PubMed:32228866, PubMed:37612504, PubMed:37612506). L-OPA1 and the soluble short form (S-OPA1) form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (PubMed:31922487, PubMed:37612504, PubMed:37612506). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (PubMed:37612504, PubMed:37612506). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (PubMed:37612504, PubMed:37612506). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (PubMed:28628083, PubMed:37612504, PubMed:37612506). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (PubMed:32567732, PubMed:33130824). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity). The equilibrium between L-OPA1 and S-OPA1 influences cristae shape and morphology: increased L-OPA1 levels promote cristae stacking and elongated mitochondria, while increased S-OPA1 levels correlated with irregular cristae packing and round mitochondria shape (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy. Publication Status: Online-Only, [RefSeq, PubMed]; Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28628083, PubMed:28746876, PubMed:31922487, PubMed:32228866, PubMed:32567732, PubMed:33130824, PubMed:33237841, PubMed:37612504, PubMed:37612506). Exists in two forms: the transmembrane, long form (Dynamin-like GTPase OPA1, long form; L-OPA1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase OPA1, short form; S-OPA1), which results from proteolytic cleavage and localizes in the intermembrane space (PubMed:31922487, PubMed:32228866, PubMed:33237841, PubMed:37612504, PubMed:37612506). Both forms (L-OPA1 and S-OPA1) cooperate to catalyze the fusion of the mitochondrial inner membrane (PubMed:31922487, PubMed:37612504, PubMed:37612506). The equilibrium between L-OPA1 and S-OPA1 is essential: excess levels of S-OPA1, produced by cleavage by OMA1 following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, inhibiting mitochondrial fusion (PubMed:20038677, PubMed:31922487). The balance between L-OPA1 and S-OPA1 also influences cristae shape and morphology (By similarity). Involved in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing by PARL in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Acts as a regulator of T-helper Th17 cells, which are characterized by cells with fused mitochondria with tight cristae, by mediating mitochondrial membrane remodeling: OPA1 is required for interleukin-17 (IL-17) production (By similarity). Its role in mitochondrial morphology is required for mitochondrial genome maintenance (PubMed:18158317, PubMed:20974897)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane., [UniProtKB, PubMed]; Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD., [RefSeq, PubMed]; OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response., [RefSeq, PubMed]; The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 55,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 18,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DNW4;E5KLJ5;E5KLJ6;E5KLJ7;E5KLK1;E5KLK2",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;7.1.1.9;7.1.1.2;3.6.1.-;3.6.5.4;2.7.11.1;3.6.-.-;3.4.24.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0070300 phosphatidic acid binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space",
        "go_biological_process": "GO:0097749 membrane tubulation;GO:0032740 positive regulation of interleukin-17 production;GO:0016559 peroxisome fission;GO:0043066 negative regulation of apoptotic process;GO:0051259 protein complex oligomerization",
        "synthesized_glycan_count": 0,
        "hit_score": 16.7,
        "record_id": "O60313-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UHI7-1",
        "uniprot_id": "S23A1_HUMAN",
        "mass": 64815.0,
        "length": 598,
        "protein_name": "Solute carrier family 23 member 1",
        "gene_name": "SLC23A1",
        "organism": "Human",
        "refseq_name": "solute carrier family 23 member 1 isoform a",
        "refseq_ac": "NP_005838",
        "gene_names_uniprotkb": "SLC23A1; SVCT1; YSPL3",
        "gene_names_refseq": "SLC23A1; SLC23A2; SVCT1; YSPL3",
        "protein_names_uniprotkb": "Solute carrier family 23 member 1; Na(+)/L-ascorbic acid transporter 1; Sodium-dependent vitamin C transporter 1; Yolk sac permease-like molecule 3; hSVCT1",
        "protein_names_refseq": "Na(+)/L-ascorbic acid transporter 1; hSVCT1; sodium-dependent vitamin C transporter-1; solute carrier family 23 (ascorbic acid transporter), member 1; solute carrier family 23 (nucleobase transporters), member 1; solute carrier family 23 (nucleobase transporters), member 2; solute carrier family 23 member 1 isoform a; yolk sac permease-like molecule 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9963);  (R-HSA-196836)",
        "pathway_count": 2,
        "publication_count": 23,
        "publication_id_list": "10471399;10556483;10556521;10631088;10783391;10862609;11237011;11396616;11584081;15970797;18619416;19379732;27862975;31154438;34780525;35494241;36310070;36749388;38956111;7668255;8513896;9228080;9804989",
        "class_list": "",
        "function": "Dimeric transport mechanism of human vitamin C transporter SVCT1. Publication Status: Online-Only, [RefSeq, PubMed]; Effects of functional variants of vitamin C transporter genes on apolipoprotein E E4-associated risk of cognitive decline: The Nakajima study. Publication Status: Online-Only, [RefSeq, PubMed]; Impact of SLC23A1 and SLC23A2 Polymorphisms on the Risk for Preeclampsia in a Chinese Han Population., [RefSeq, PubMed]; Inactive transporter., [UniProtKB, PubMed]; Sodium:ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10556483, PubMed:10556521, PubMed:10631088, PubMed:36749388). Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber (PubMed:36749388)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]., [RefSeq]; Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 3,
        "mined_n_glycosites": 3,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95191;Q8WWB6;Q9UGH4;Q9UI39",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008520 L-ascorbate:sodium symporter activity;GO:0015205 nucleobase transmembrane transporter activity;GO:0015229 L-ascorbic acid transmembrane transporter activity;GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0015081 sodium ion transmembrane transporter activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane",
        "go_biological_process": "GO:0015851 nucleobase transport;GO:0015882 L-ascorbic acid transmembrane transport;GO:0070837 dehydroascorbic acid transport;GO:0030324 lung development;GO:0007420 brain development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q9UHI7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NTM9-1",
        "uniprot_id": "CUTC_HUMAN",
        "mass": 29341.0,
        "length": 273,
        "protein_name": "Copper homeostasis protein cutC homolog",
        "gene_name": "CUTC",
        "organism": "Human",
        "refseq_name": "copper homeostasis protein cutC homolog",
        "refseq_ac": "NP_057044",
        "gene_names_uniprotkb": "CUTC; CGI-32",
        "gene_names_refseq": "CGI-32; CUTC",
        "protein_names_uniprotkb": "Copper homeostasis protein cutC homolog",
        "protein_names_refseq": "copper homeostasis protein cutC homolog; cutC copper transporter homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51076);  (R-HSA-936837)",
        "pathway_count": 2,
        "publication_count": 48,
        "publication_id_list": "10401004;10484781;10615129;10767338;11237011;15831496;15919184;15925480;16182249;1656976;16700898;16959974;18723824;19345671;19878721;2160952;22186024;23196729;24392018;25418920;25892735;26154972;26992070;27067231;27846572;27920218;28510447;28514659;28832583;28834231;28904123;29557506;31092671;31844290;32161166;32938616;33912179;35051231;35705054;36284347;6832622;7626145;8045293;8298639;8490646;8490659;9147644;9307043",
        "class_list": "",
        "function": "Cloning, expression and subcellular localization of CutC., [RefSeq, PubMed]; May play a role in copper homeostasis. Can bind one Cu(1+) per subunit., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008]., [RefSeq]; Results suggest that hCutC functions as an enzyme with Cu(I) as a cofactor rather than a copper transporter and the potential Cu(I)-binding site consists of the two Cys residues and other conserved residues in the vicinity., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TCZ8;Q9Y321",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005507 copper ion binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0051262 protein tetramerization;GO:0006825 copper ion transport;GO:0055070 copper ion homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q9NTM9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43324-1",
        "uniprot_id": "MCA3_HUMAN",
        "mass": 19811.0,
        "length": 174,
        "protein_name": "Eukaryotic translation elongation factor 1 epsilon-1",
        "gene_name": "EEF1E1",
        "organism": "Human",
        "refseq_name": "eukaryotic translation elongation factor 1 epsilon-1 isoform 2",
        "refseq_ac": "NP_001129122",
        "gene_names_uniprotkb": "EEF1E1; AIMP3; P18",
        "gene_names_refseq": "AIMP3; EEF1E1; P18",
        "protein_names_uniprotkb": "Eukaryotic translation elongation factor 1 epsilon-1; Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; Elongation factor p18; Multisynthase complex auxiliary component p18",
        "protein_names_refseq": "ARS-interacting multifunctional protein 3; aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; eukaryotic translation elongation factor 1 epsilon-1 isoform 2; multisynthase complex auxiliary component p18; multisynthetase complex auxiliary component p18; p18 component of aminoacyl-tRNA synthetase complex",
        "tax_id": 9606,
        "disease": "stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:9521);  (R-HSA-2408522);  (R-HSA-379716);  (R-HSA-9856649)",
        "pathway_count": 4,
        "publication_count": 162,
        "publication_id_list": "10567402;10611221;10655586;10673502;11027551;11237011;11347887;11714285;11829477;11840323;11858721;11891324;11912130;11930005;12690580;1373391;14660560;14671330;14975237;15118077;15226305;15507434;15680327;16014379;16034366;16055448;16429158;16661668;16661782;16822840;16906134;1698554;1748288;1761529;17623675;18343821;18644867;18991276;19131329;19289464;19524539;19608861;19748539;20068231;20460180;21486943;21872626;21965087;22424782;22544926;22647378;22898188;23159739;23190890;23207919;24714562;24715725;25248477;25595898;25645385;25810538;25880248;25892735;26154972;26472928;26992070;27128622;27600516;28228285;28394346;28797100;28832583;28834231;29242379;29295999;29493099;29508533;29557506;29632711;29769354;29786170;30315122;30524438;30706629;30779550;30804224;30833945;31217245;31222486;31611695;31844290;31848261;31937595;31998317;32350084;32357974;32387766;32488085;32502341;32636443;32897882;32938616;32983136;33141586;33214551;33392160;33465208;33537174;33538115;33592498;33691108;33744299;33912179;33936100;33968037;33981976;34019948;34087483;34140478;34171305;34211107;34357683;34405274;34509645;35051231;35251023;35254053;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37770430;37938771;38665916;40596516;4130389;5338216;6022858;656444;7118399;7654687;7958932;8052601;8078941;8188258;8336698;8428657;8449960;9199364;9278442;9353119;9421509;9431993;9440696;9560246;9653160;9676189;9760192;9973413",
        "class_list": "",
        "function": "AIMP3 inhibits cell growth and metastasis of lung adenocarcinoma through activating a miR-96-5p-AIMP3-p53 axis., [RefSeq, PubMed]; Analysis of the heterotetrameric complex structure of the glutathione transferase (GST) domains shared among the four MSC components, methionyl-tRNA synthetase (MRS), glutaminyl-prolyl-tRNA synthetase (EPRS), AIMP2 and AIMP3, [RefSeq, PubMed]; LmnA binds AIMP3 via its extreme C-terminus. Together these findings provide a structural insight for understanding the interaction between AIMP3 and LmnA in AIMP3 degradation. Publication Status: Online-Only, [RefSeq, PubMed]; Positive modulator of ATM response to DNA damage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The AIMP3 enhanced mitochondrial respiration and suppressed autophagic activity, indicating that the AIMP3-associated modulation of metabolism and autophagy is a key mechanism in the senescence of stem cells and further suggesting a novel target for interventions against aging., [RefSeq, PubMed]; This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JLK5;Q5THS2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex",
        "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0006418 tRNA aminoacylation for protein translation;GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:2000774 positive regulation of cellular senescence",
        "synthesized_glycan_count": 0,
        "hit_score": 16.6,
        "record_id": "O43324-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P07585-1",
        "uniprot_id": "PGS2_HUMAN",
        "mass": 39747.0,
        "length": 359,
        "protein_name": "Decorin",
        "gene_name": "DCN",
        "organism": "Human",
        "refseq_name": "decorin isoform a preproprotein",
        "refseq_ac": "NP_001911",
        "gene_names_uniprotkb": "DCN; SLRR1B",
        "gene_names_refseq": "CSCD; DCN; DSPG2; PG40; PGII; PGS2; SLRR1B",
        "protein_names_uniprotkb": "Decorin; Bone proteoglycan II; PG-S2; PG40",
        "protein_names_refseq": "bone proteoglycan II; decorin isoform a preproprotein; dermatan sulphate proteoglycans II; proteoglycan core protein; small leucine-rich protein 1B",
        "tax_id": 9606,
        "disease": "congenital stromal corneal dystrophy (Disease Ontology:DOID:0060445); syndromic X-linked intellectual disability Pilorge type (Disease Ontology:DOID:0070422); gestational diabetes (Disease Ontology:DOID:11714); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); breast carcinoma (Disease Ontology:DOID:3459); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:1634);  (R-HSA-1474228);  (R-HSA-1971475);  (R-HSA-2022870);  (R-HSA-2022923);  (R-HSA-2024101);  (R-HSA-3000178);  (R-HSA-3560783);  (R-HSA-3560801);  (R-HSA-3595172);  (R-HSA-3595174);  (R-HSA-3595177);  (R-HSA-4420332)",
        "pathway_count": 13,
        "publication_count": 206,
        "publication_id_list": "10.1101/2023.09.13.557529;10022829;10187838;10229672;10339581;10339611;10386589;10473568;10506123;10673326;10706100;10781596;10781601;10809722;10842173;10963998;10986281;11056388;11084047;11099377;11139592;11237011;11259413;11375993;11414686;11470797;11514575;11551958;11568288;11788602;11805522;11872628;11877387;12080076;12145278;12163485;12225811;12473204;12512856;12522689;12556911;12727852;12761225;12843408;12874280;12888274;12907687;1376317;14715956;14973287;14993226;15075323;15211654;15215498;15234972;15294915;15296743;1544908;15461586;15591058;15647514;15671264;15958533;16133547;16293224;16493581;1649600;16505484;16631740;16825321;16935612;1698775;1707285;17194707;17227754;17332331;17354228;17588949;17608959;18316376;18434311;18513679;18658137;18698629;19010778;1907800;19159218;19188366;19224584;1928092;1946389;19473117;19571574;19657146;19661164;19714641;19889881;20004762;20142769;20533528;2059554;20691685;20830804;21030783;21081667;21129727;21129728;2122463;21297635;21441952;21642437;21670566;21763480;21784848;21789315;21864727;21993463;22134916;22159414;22810237;23035980;23090970;2364322;23656592;23664117;23664118;23704329;23845380;2412224;24190977;2420006;2430969;24413633;24425863;24443026;25326458;25521717;25576301;2590169;27599773;29514872;29557506;2971395;29741879;29786170;29789417;30429286;31154438;3134052;31844290;31848261;32157095;32337544;33968037;3468507;3484330;35051231;3597437;36213313;36929160;37074911;37453717;38243615;38665916;39045898;5304426;5822067;6193777;6439184;7075587;738706;7499434;7527058;7542669;7547873;7559467;7628016;7685013;7693733;7852349;8002934;8213840;8226919;8432526;8432527;8440685;8626565;8798654;8943283;9065415;9115292;9148753;9223416;9252349;9294172;9341124;9346959;9461298;9506957;9521684;9685393;9823490;9852107;9883891;9892646;9949188",
        "class_list": "glycogene",
        "function": "Decorin attenuates hypertrophic scar fibrosis via TGFbeta/Smad signalling., [RefSeq, PubMed]; HBx downregulated decorin and decorin-derived peptides inhibit the proliferation and tumorigenicity of hepatocellular carcinoma cells., [RefSeq, PubMed]; May affect the rate of fibrils formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The effects of TGF-beta1 and IFN-alpha2b on decorin, decorin isoforms and type I collagen in hypertrophic scar dermal fibroblasts., [RefSeq, PubMed]; This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 469,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 197,
        "disease_count": 10,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9P0Z0;Q9P0Z1;Q9Y5N8;Q9Y5N9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0050840 extracellular matrix binding;GO:0005539 glycosaminoglycan binding;GO:0030021 extracellular matrix structural constituent conferring compression resistance",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0031012 extracellular matrix;GO:0043202 lysosomal lumen",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0009887 animal organ morphogenesis;GO:0010508 positive regulation of autophagy;GO:0016525 negative regulation of angiogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 41.1,
        "record_id": "P07585-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9ULU4-1",
        "uniprot_id": "ZMYD8_HUMAN",
        "mass": 131692.0,
        "length": 1186,
        "protein_name": "MYND-type zinc finger-containing chromatin reader ZMYND8",
        "gene_name": "ZMYND8",
        "organism": "Human",
        "refseq_name": "MYND-type zinc finger-containing chromatin reader ZMYND8 isoform e",
        "refseq_ac": "NP_001268700",
        "gene_names_uniprotkb": "ZMYND8; KIAA1125; PRKCBP1; RACK7",
        "gene_names_refseq": "PRKCBP1; PRO2893; RACK7; ZMYND8",
        "protein_names_uniprotkb": "MYND-type zinc finger-containing chromatin reader ZMYND8; CTCL-associated antigen se14-3; Cutaneous T-cell lymphoma-associated antigen se14-3; Protein kinase C-binding protein 1; Rack7; Transcription coregulator ZMYND8; Zinc finger MYND domain-containing protein 8",
        "protein_names_refseq": "CTCL tumor antigen se14-3; MYND-type zinc finger-containing chromatin reader ZMYND8 isoform e; MYND-type zinc finger-containing chromatin reader ZMYND8; RACK like clone 7; cutaneous T-cell lymphoma-associated antigen se14-3; predicted protein of HQ2893; protein kinase C-binding protein 1; transcription coregulator ZMYND8; zinc finger MYND domain-containing protein 8",
        "tax_id": 9606,
        "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)",
        "pathway": " (hsa:23613);  (R-HSA-9940951)",
        "pathway_count": 2,
        "publication_count": 105,
        "publication_id_list": "10.1101/2023.09.13.557529;10204490;10970879;10978333;11003709;11149944;11237011;17081983;17525332;17646674;18669648;19608861;19690332;20068231;21406692;22661428;23186163;23301498;23481700;24275569;24554700;24715725;25150861;25218447;25505266;25576301;25593309;25645385;25755297;25772364;26154972;26375851;26655721;27477906;27633282;27732854;27846572;28834231;28904123;28966017;29042441;29437277;29493099;29557506;29632711;29789417;30045876;30134174;30315122;30379171;30524438;30620550;30779550;31154438;31222486;31530632;31746185;31844290;31848261;31965980;32119511;32157095;32357974;32387766;32488085;32502341;32574038;32938616;32938750;33141586;33214551;33298915;33323928;33592498;33717175;33936100;33968037;34019948;34087483;34171305;34211107;34509645;34725712;34846842;35051231;35132862;35154160;35254053;35580925;35916866;36008597;36010968;36064715;36284347;37541260;37938771;38253038;38665916;38804064;39128723;39302247;39531497;40596516;7969165;9512513",
        "class_list": "",
        "function": "Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations., [RefSeq, PubMed]; The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion., [RefSeq, PubMed]; ZMYND8 Is a Regulator of Sonic Hedgehog Signaling in ATRA-Mediated Differentiation of Neuroblastoma Cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 13,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 13,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 13,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 30,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVL2;B7Z2A8;B7Z3E0;B7Z680;B7ZM62;E1P5U5;F5H0X3;H7C0U2;J3KPU3;Q13517;Q2HXV1;Q2HXV2;Q2HXV3;Q2HXV4;Q2HXV7;Q2HXV8;Q2HXV9;Q2HXW0;Q2HXW1;Q2HXW2;Q4JJ94;Q4JJ95;Q5TH09;Q5TH11;Q6MZM1;Q8WXC5;Q9H1F3;Q9H1F4;Q9H1F5;Q9H1L8;Q9H1L9;Q9H2G5;Q9NYN3;Q9UIX6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity;GO:0140297 DNA-binding transcription factor binding;GO:0140015 histone H3K14ac reader activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0043197 dendritic spine",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0098815 modulation of excitatory postsynaptic potential;GO:0030336 negative regulation of cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "Q9ULU4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86W54-1",
        "uniprot_id": "SPA24_HUMAN",
        "mass": 23587.0,
        "length": 205,
        "protein_name": "Spermatogenesis-associated protein 24",
        "gene_name": "SPATA24",
        "organism": "Human",
        "refseq_name": "spermatogenesis-associated protein 24",
        "refseq_ac": "NP_919272",
        "gene_names_uniprotkb": "SPATA24",
        "gene_names_refseq": "CCDC161; SPATA24; T6441",
        "protein_names_uniprotkb": "Spermatogenesis-associated protein 24; Testis protein T6441 homolog",
        "protein_names_refseq": "coiled-coil domain containing 161; spermatogenesis-associated protein 24; testis protein T6441 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:202051)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;19240791;19515240;26374642;28832583;29242379;31844290;31998317;32157095",
        "class_list": "",
        "function": "Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity)., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q86W54-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14770-1",
        "uniprot_id": "MEIS2_HUMAN",
        "mass": 51790.0,
        "length": 477,
        "protein_name": "Homeobox protein Meis2",
        "gene_name": "MEIS2",
        "organism": "Human",
        "refseq_name": "homeobox protein Meis2 isoform d",
        "refseq_ac": "NP_001207411",
        "gene_names_uniprotkb": "MEIS2; MRG1",
        "gene_names_refseq": "CPCMR; HsT18361; MEIS2; MRG1",
        "protein_names_uniprotkb": "Homeobox protein Meis2; Meis1-related protein 1",
        "protein_names_refseq": "Meis homolog 2; Meis1, myeloid ecotropic viral integration site 1 homolog 2; Meis1-related gene 1; TALE homeobox protein Meis2; homeobox protein Meis2 isoform d; meis1-related protein 1",
        "tax_id": 9606,
        "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); orofacial cleft (Disease Ontology:DOID:0050567); cleft palate, cardiac defects, and intellectual disability (Disease Ontology:DOID:0111697); open-angle glaucoma (Disease Ontology:DOID:1067); leukemia (Disease Ontology:DOID:1240); brain infarction (Disease Ontology:DOID:3454); cleft palate (Disease Ontology:DOID:674); learning disability (Disease Ontology:DOID:8927)",
        "pathway": " (hsa:4212)",
        "pathway_count": 1,
        "publication_count": 35,
        "publication_id_list": "10764806;11237011;11279116;19559479;19651622;20523026;20553494;21746878;24678003;25576301;25712757;25880248;26154972;26550823;26992070;27225850;27846572;27920218;28832583;29485866;29557506;31154438;31222486;31844290;32897882;32938616;33298915;34171305;36010968;36284347;37660994;38153233;38347632;38711262;9383298",
        "class_list": "",
        "function": "Cellular Ligand-Receptor Perturbations Unravel MEIS2 as a Key Factor for the Aggressive Progression and Prognosis in Stage II/III Colorectal Cancer., [RefSeq, PubMed]; Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription., [UniProtKB, PubMed, PubMed, PubMed]; LINC-PINT suppresses breast cancer cell proliferation and migration via MEIS2/PPP3CC/NF-kappaB pathway by sponging miR-576-5p., [RefSeq, PubMed]; MEIS2 suppresses breast cancer development by downregulating IL10., [RefSeq, PubMed]; Novel genetic markers for chronic kidney disease in a geographically isolated population of Indigenous Australians: Individual and multiple phenotype genome-wide association study. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJI5;A8MWD5;B3KP98;B3KPQ6;Q96DI2;Q96KI4;Q96KI5;Q9NRS1;Q9NRS2;Q9NRS3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008134 transcription factor binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0045931 positive regulation of mitotic cell cycle;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "O14770-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NBM4-1",
        "uniprot_id": "UBAC2_HUMAN",
        "mass": 38964.0,
        "length": 344,
        "protein_name": "Ubiquitin-associated domain-containing protein 2",
        "gene_name": "UBAC2",
        "organism": "Human",
        "refseq_name": "ubiquitin-associated domain-containing protein 2 isoform 1 precursor",
        "refseq_ac": "NP_001137544",
        "gene_names_uniprotkb": "UBAC2; PHGDHL1; PSEC0110",
        "gene_names_refseq": "PHGDHL1; UBAC2",
        "protein_names_uniprotkb": "Ubiquitin-associated domain-containing protein 2; Phosphoglycerate dehydrogenase-like protein 1; UBA domain-containing protein 2",
        "protein_names_refseq": "RP11-178C10.1; UBA domain-containing protein 2; phosphoglycerate dehydrogenase like 1; phosphoglycerate dehydrogenase-like protein 1; ubiquitin-associated domain-containing protein 2 isoform 1 precursor; ubiquitin-associated domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:337867)",
        "pathway_count": 1,
        "publication_count": 69,
        "publication_id_list": "11237011;16303743;17074750;21918955;23297223;24714562;24715725;25576301;25645385;26154972;26728094;26992070;27397612;27600516;27846572;27862975;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632711;29769354;29786170;30315122;30410026;30429286;30779550;31073040;31092671;31154438;31217245;31844290;31848261;32157095;32357974;32387766;32488085;32897882;32913183;32938616;32983136;33141586;33392160;33537174;33592498;33691108;33717175;33968037;33981976;34087483;34171305;34405274;34509645;34932366;35020141;35051231;35580925;36010968;36284347;37938771;39284914",
        "class_list": "",
        "function": "Acts as an ER-phagy receptor required for the selective autophagic degradation of endoplasmic reticulum (ER) fragments to maintain ER homeostasis and restrain ER stress-induced inflammatory responses (PubMed:39284914). Its function depends on phosphorylation-induced dimerization, which enhances interaction with GABARAP and facilitates recruitment of ER fragments to autophagosomes (PubMed:39284914). Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (PubMed:23297223). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040)., [UniProtKB, PubMed, PubMed, PubMed]; Association between UBAC2 gene polymorphism and the risk of noise-induced hearing loss: a cross-sectional study., [RefSeq, PubMed]; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets. In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6., [UniProtKB, UniProtKB]; UBAC2 promotes bladder cancer proliferation through BCRC-3/miRNA-182-5p/p27 axis. Publication Status: Online-Only, [RefSeq, PubMed]; We established and confirmed the genetic association between UBAC2 and Behcet's disease in 3 independent sets of patients and controls, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KNV7;Q0VAB5;Q5W0W6;Q5W0W9;Q6GQR2;Q6P4B0;Q8N2E8;Q96NW2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0070972 protein localization to endoplasmic reticulum;GO:1904153 negative regulation of retrograde protein transport, ER to cytosol",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q8NBM4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UBV7-1",
        "uniprot_id": "B4GT7_HUMAN",
        "mass": 37406.0,
        "length": 327,
        "protein_name": "Beta-1,4-galactosyltransferase 7",
        "gene_name": "B4GALT7",
        "organism": "Human",
        "refseq_name": "beta-1,4-galactosyltransferase 7",
        "refseq_ac": "NP_009186",
        "gene_names_uniprotkb": "B4GALT7; PRO1478; XGALT1",
        "gene_names_refseq": "B4GALT7; EDSP1; EDSSLA; EDSSPD1; XGALT1; XGPT1; XGPT",
        "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 7; 2.4.1.-; 2.4.1.133; Beta-1,4-GalTase 7; Beta4Gal-T7; Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7; UDP-galactose:beta-xylose beta-1,4-galactosyltransferase; XGPT; XGalT-1; Xylosylprotein 4-beta-galactosyltransferase; Xylosylprotein beta-1,4-galactosyltransferase; b4Gal-T7",
        "protein_names_refseq": "UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7; UDP-galactose:beta-xylose beta-1,4-galactosyltransferase; beta-1,4-GalTase 7; beta-1,4-galactosyltransferase 7; beta-1,4-galactosyltransferase VII; beta4Gal-T7; beta4GalT-VII; galactosyltransferase I; proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I; xylosylprotein 4-beta-galactosyltransferase; xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7; xylosylprotein beta-1,4-galactosyltransferase",
        "tax_id": 9606,
        "disease": "Ehlers-Danlos syndrome spondylodysplastic type 1 (Disease Ontology:DOID:0080738); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); Ehlers-Danlos syndrome, spondylodysplastic type (MONDO:MONDO:0007526)",
        "pathway": " (hsa:11285);  (R-HSA-1971475);  (R-HSA-3560783)",
        "pathway_count": 3,
        "publication_count": 49,
        "publication_id_list": "10438455;10473568;10506123;10580128;10842173;11099377;11237011;11551958;11877387;1221956;12522689;12975309;14993226;15211654;15294915;15461586;1640425;17194707;18158310;19473117;19615748;20691685;22810237;23656592;23956117;24052259;24425863;24443026;24715725;24755949;25521717;26940150;28218747;29242379;29314611;29437277;29632046;31278392;31614862;31844290;33936100;34357683;35251023;3631078;38025683;38665916;40307207;9506957;9892646",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Define some of the clinical features of B4GALT7 and B3GALT6-related conditions and underlined the extreme hypermobility of distal joints and the soft, doughy skin on the hands and feet as features that may be useful as the first clues for a correct diagnosis. Publication Status: Online-Only, [RefSeq, PubMed]; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts., [UniProtKB, PubMed]; Targeting B4GALT7 suppresses the proliferation, migration and invasion of hepatocellular carcinoma through the Cdc2/CyclinB1 and miR-338-3p/MMP2 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The findings in this family expand the clinical phenotype of B4GALT7-related linkeropathies to include perinatal lethal skeletal dysplasia, [RefSeq, PubMed]; This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. Mutations in this gene have been associated with the progeroid form of Ehlers-Danlos syndrome. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 526,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KN39;Q9UHN2",
        "ec_number_list": "2.4.1.-;2.4.1.133",
        "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0030145 manganese ion binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0046525 xylosylprotein 4-beta-galactosyltransferase activity;GO:0016757 glycosyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0036211 protein modification process;GO:0005975 carbohydrate metabolic process;GO:0048147 negative regulation of fibroblast proliferation;GO:0006487 protein N-linked glycosylation;GO:0006024 glycosaminoglycan biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q9UBV7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NX01-1",
        "uniprot_id": "TXN4B_HUMAN",
        "mass": 17015.0,
        "length": 149,
        "protein_name": "Thioredoxin-like protein 4B",
        "gene_name": "TXNL4B",
        "organism": "Human",
        "refseq_name": "thioredoxin-like protein 4B isoform 1",
        "refseq_ac": "NP_001135789",
        "gene_names_uniprotkb": "TXNL4B; DIM2; DLP",
        "gene_names_refseq": "DLP; Dim2; TXNL4B",
        "protein_names_uniprotkb": "Thioredoxin-like protein 4B; Dim1-like protein",
        "protein_names_refseq": "Dim1-like protein; thioredoxin-like protein 4B isoform 1; thioredoxin-like protein 4B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54957)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;15161931;16142897;18669648;26992070;30379171;30429286;31844290;33392160;33717175;33912179;35580925;36010968;37938771",
        "class_list": "",
        "function": "Crystal structure; in contrast to hDim1, hDim2 forms stable homodimers, [RefSeq, PubMed]; DLP is implicated in not only cell cycle progression but also in a more specific molecular process such as pre-mRNA splicing, [RefSeq, PubMed]; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DWS6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0005682 U5 snRNP;GO:0046540 U4/U6 x U5 tri-snRNP complex",
        "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11);GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q9NX01-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y6W3-1",
        "uniprot_id": "CAN7_HUMAN",
        "mass": 92652.0,
        "length": 813,
        "protein_name": "Calpain-7",
        "gene_name": "CAPN7",
        "organism": "Human",
        "refseq_name": "calpain-7 isoform 1",
        "refseq_ac": "NP_055111",
        "gene_names_uniprotkb": "CAPN7; PALBH",
        "gene_names_refseq": "CALPAIN7; CAPN7; PALBH",
        "protein_names_uniprotkb": "Calpain-7; 3.4.22.-; PalB homolog; PalBH",
        "protein_names_refseq": "calpain like protease; calpain-7 isoform 1; homolog of Aspergillus Nidulans PALB; palB homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23473);  (R-HSA-1474228)",
        "pathway_count": 2,
        "publication_count": 116,
        "publication_id_list": "10229672;10386589;10706100;10809722;10986281;11237011;11342116;11375993;11872628;12727852;12843408;14973287;15234972;15591058;15958533;16133547;1649600;16631740;16825321;1698775;1707285;17332331;17354228;17608959;18434311;18658137;19010778;19571574;19657146;19690332;19714641;20142769;20849418;21030783;21297635;21441952;21670566;21784848;21864727;22159414;23035980;23481700;23497113;23845380;23855590;24714562;24953135;25576301;25892735;26154972;26375851;26728094;26992070;27600516;27846572;27920218;28218747;28467828;28832583;28834231;28904123;29242379;29351928;29493099;29508533;29557506;29632711;29786170;30410026;30429286;31324691;31844290;31848261;31937595;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33912179;33936100;33968037;33981976;34087483;34185709;34357683;34405274;34509645;34932366;35051231;35191464;35251023;35561310;35580925;36010968;36215666;36241641;7075587;7547873;8226919;8626565;9065415;9115292;9148753;9461298;9852107",
        "class_list": "",
        "function": "Calcium-regulated non-lysosomal thiol-protease., [UniProtKB]; Calpain7 negatively regulates human endometrial stromal cell decidualization in EMs by promoting FoxO1 nuclear exclusion via hydrolyzing AKT1., [RefSeq, PubMed]; Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]., [RefSeq]; Data indicate that CAPN 7 promotes endometrial stromal cell (hESC) migration and invasion by increasing the activity of MMP-2 via an increased ratio of MMP-2 to TIMP-2. Publication Status: Online-Only, [RefSeq, PubMed]; Mutational analysis of calpain-7 reveals the importance of not only the N-terminal microtubule-interacting and trafficking domains but also the C-terminal C2 domain-like domains for proteolytic activity., [RefSeq, PubMed]; Results demonstrate that human calpain 7 is proteolytically active, and imply that calpain 7 is activated by ESCRT-III-related protein IST1., [RefSeq, PubMed]; The proteolytic activity of CAPN7 is important for the acceleration of EGFR degradation via the endosomal sorting pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "3.4.22.53;3.4.22.-;3.4.22.52;3.4.22.54",
        "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0090541 MIT domain binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006508 proteolysis;GO:0010634 positive regulation of epithelial cell migration;GO:0097264 self proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 11.9,
        "record_id": "Q9Y6W3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14687-1",
        "uniprot_id": "GSE1_HUMAN",
        "mass": 136164.0,
        "length": 1217,
        "protein_name": "Genetic suppressor element 1",
        "gene_name": "GSE1",
        "organism": "Human",
        "refseq_name": "genetic suppressor element 1 isoform 2",
        "refseq_ac": "NP_001127945",
        "gene_names_uniprotkb": "GSE1; KIAA0182",
        "gene_names_refseq": "CRHSP24; GSE1; KIAA0182",
        "protein_names_uniprotkb": "Genetic suppressor element 1",
        "protein_names_refseq": "CTC-786C10.1; Gse1 coiled-coil protein homolog; genetic suppressor element 1 isoform 2; genetic suppressor element 1",
        "tax_id": 9606,
        "disease": "stomach cancer (Disease Ontology:DOID:10534)",
        "pathway": " (hsa:23199)",
        "pathway_count": 1,
        "publication_count": 101,
        "publication_id_list": "11237011;12493763;15302935;16959974;18452278;18669648;18767875;19608861;19651622;19664994;19664995;19690332;20068231;22898188;23186163;23481700;24129315;24275569;24714562;24715725;25418920;25576301;26154972;26811146;26828271;26992070;27543614;27846572;27862975;27920218;28218747;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29508533;29557506;29632046;29632711;29786170;30192525;30379171;30410026;30429286;30484775;30779550;30833945;31154438;31217245;31492838;31530632;31844290;31848261;31998317;32157095;32350084;32357974;32387766;32488085;32502341;32574038;32897882;32938616;32938750;32983136;33141586;33214551;33298915;33392160;33592498;33623790;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34509645;34932366;35051231;35132862;35138101;35251023;35254053;35318648;35580925;36010968;36215666;36241641;36284347;37878419;38665916;38886911;39531497;39534244;40307207",
        "class_list": "",
        "function": "GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage., [RefSeq, PubMed]; GSE1 promotes the proliferation and migration of lung adenocarcinoma cells by downregulating KLF6 expression., [RefSeq, PubMed]; Overexpression of GSE1 Related to Trastuzumab Resistance in Gastric Cancer Cells. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a proline-rich protein with coiled coil domains that may be a subunit of a BRAF35-HDAC (BHC) histone deacetylase complex. This gene may function as an oncogene in breast cancer and enhanced expression of the encoded protein has been observed in breast cancer patients. [provided by RefSeq, May 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 12,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 12,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 12,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 45,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DUM4;Q8IY61;Q96GA4;Q9BW09",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "Q14687-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N8Q1-1",
        "uniprot_id": "C56D1_HUMAN",
        "mass": 25424.0,
        "length": 229,
        "protein_name": "Probable transmembrane reductase CYB561D1",
        "gene_name": "CYB561D1",
        "organism": "Human",
        "refseq_name": "probable transmembrane reductase CYB561D1 isoform 1",
        "refseq_ac": "NP_001127872",
        "gene_names_uniprotkb": "CYB561D1",
        "gene_names_refseq": "CYB561D1",
        "protein_names_uniprotkb": "Probable transmembrane reductase CYB561D1; 7.2.1.3; Cytochrome b561 domain-containing protein 1",
        "protein_names_refseq": "cytochrome b-561 domain containing 1; cytochrome b561 domain-containing protein 1; probable transmembrane reductase CYB561D1 isoform 1; probable transmembrane reductase CYB561D1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284613)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;16344560;23481700;35051231",
        "class_list": "",
        "function": "Probable transmembrane reductase that may use ascorbate as an electron donor and transfer electrons across membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in another cellular compartment., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DH97;E9PCM8;Q52M36;Q5T6C2;Q5T6C3",
        "ec_number_list": "7.2.1.3",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0140575 transmembrane monodehydroascorbate reductase activity;GO:0140571 transmembrane ascorbate ferrireductase activity",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8N8Q1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NZ81-1",
        "uniprot_id": "PRR13_HUMAN",
        "mass": 15385.0,
        "length": 148,
        "protein_name": "Proline-rich protein 13",
        "gene_name": "PRR13",
        "organism": "Human",
        "refseq_name": "proline-rich protein 13 isoform 2",
        "refseq_ac": "NP_001005354",
        "gene_names_uniprotkb": "PRR13; BM-041; TXR1",
        "gene_names_refseq": "PRR13; TXR1",
        "protein_names_uniprotkb": "Proline-rich protein 13; Taxane-resistance protein",
        "protein_names_refseq": "proline-rich protein 13 isoform 2; proline-rich protein 13; taxane-resistance protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54458)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;16847352;19435835;21157449;24362794;27600516;27779244;28345125;28832583;29242379;29557506;31020640;31092671;31844290;32161166;32350084;32983136;33592498;33691108;35051231;35580925",
        "class_list": "",
        "function": "High Txr1 expression is associated with oxaliplatin resistance in gastric cancer., [RefSeq, PubMed]; In primary glioblastoma samples there was a high expression of TXR1 in cerebral tissue compared to control tissue., [RefSeq, PubMed]; Low TXR1 mRNA levels were associated with higher response rate (RR), longer median progression-free survival (PFS) and median overall survival (mOS), whereas high TSP1 expression was correlated with higher RR, longer PFS and mOS, [RefSeq, PubMed]; Multivariate analysis showed that high TXR1/low TSP1 expression was an independent prognostic factor for decreased median time to tumor progression (TTP) and median overall survival (mOS)., [RefSeq, PubMed]; Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis., [UniProtKB, PubMed]; These findings indicate that PRR13/THBS1 and TXN expression could be used for the prediction of resistance to treatment of epithelial ovarian cancer patients., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0V8U0;Q6FIG7;Q6MZP8;Q6NXQ6;Q6PKF9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q9NZ81-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P60900-1",
        "uniprot_id": "PSA6_HUMAN",
        "mass": 27399.0,
        "length": 246,
        "protein_name": "Proteasome subunit alpha type-6",
        "gene_name": "PSMA6",
        "organism": "Human",
        "refseq_name": "proteasome subunit alpha type-6 isoform b",
        "refseq_ac": "NP_001269161",
        "gene_names_uniprotkb": "PSMA6; PROS27",
        "gene_names_refseq": "IOTA; PROS27; PSMA6; p27K",
        "protein_names_uniprotkb": "Proteasome subunit alpha type-6; 27 kDa prosomal protein; Macropain iota chain; Multicatalytic endopeptidase complex iota chain; PROS-27; Proteasome iota chain; Proteasome subunit alpha-1; alpha-1; p27K",
        "protein_names_refseq": "27 kDa prosomal protein; PROS-27; alpha-1; macropain iota chain; macropain subunit iota; multicatalytic endopeptidase complex iota chain; prosomal P27K protein; proteasome (prosome, macropain) subunit, alpha type, 6; proteasome iota chain; proteasome subunit alpha 6; proteasome subunit alpha type-6 isoform b; proteasome subunit alpha-1; proteasome subunit alpha1; proteasome subunit iota; testicular secretory protein Li 44",
        "tax_id": 9606,
        "disease": "myocardial infarction (Disease Ontology:DOID:5844)",
        "pathway": " (hsa:5687);  (R-HSA-1169091);  (R-HSA-1234176);  (R-HSA-1236974);  (R-HSA-1236978);  (R-HSA-174084);  (R-HSA-174113);  (R-HSA-174154);  (R-HSA-174178);  (R-HSA-174184);  (R-HSA-180534);  (R-HSA-180585);  (R-HSA-187577);  (R-HSA-195253);  (R-HSA-202424);  (R-HSA-211733);  (R-HSA-2467813);  (R-HSA-2871837);  (R-HSA-349425);  (R-HSA-350562);  (R-HSA-382556);  (R-HSA-450408);  (R-HSA-4608870);  (R-HSA-4641257);  (R-HSA-4641258);  (R-HSA-5358346);  (R-HSA-5362768);  (R-HSA-5607761);  (R-HSA-5607764);  (R-HSA-5610780);  (R-HSA-5610783);  (R-HSA-5610785);  (R-HSA-5632684);  (R-HSA-5658442);  (R-HSA-5668541);  (R-HSA-5676590);  (R-HSA-5678895);  (R-HSA-5687128);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-68867);  (R-HSA-68949);  (R-HSA-69017);  (R-HSA-69481);  (R-HSA-69601);  (R-HSA-75815);  (R-HSA-8852276);  (R-HSA-8854050);  (R-HSA-8939236);  (R-HSA-8939902);  (R-HSA-8941858);  (R-HSA-8948751);  (R-HSA-8951664);  (R-HSA-9010553);  (R-HSA-9020702);  (R-HSA-9604323);  (R-HSA-9755511);  (R-HSA-9762114);  (R-HSA-9766229);  (R-HSA-9824272);  (R-HSA-983168);  (R-HSA-9907900);  (R-HSA-9912633);  (R-HSA-9929356);  (R-HSA-9929491);  (R-HSA-9931269);  (R-HSA-9932298);  (R-HSA-9954709);  (R-HSA-9958825)",
        "pathway_count": 69,
        "publication_count": 1050,
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        "class_list": "",
        "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7J9;B4DQR4;B4DXJ9;P34062;Q6IB60",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0004175 endopeptidase activity;GO:0051059 NF-kappaB binding;GO:0035639 purine ribonucleoside triphosphate binding",
        "go_cellular_component": "GO:0097229 sperm end piece;GO:0034515 proteasome storage granule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045061 thymic T cell selection;GO:0045063 T-helper 1 cell differentiation;GO:0071357 cellular response to type I interferon;GO:0043374 CD8-positive, alpha-beta T cell differentiation;GO:0006281 DNA repair",
        "synthesized_glycan_count": 0,
        "hit_score": 105.3,
        "record_id": "P60900-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9ULK2-1",
        "uniprot_id": "AT7L1_HUMAN",
        "mass": 91514.0,
        "length": 861,
        "protein_name": "Ataxin-7-like protein 1",
        "gene_name": "ATXN7L1",
        "organism": "Human",
        "refseq_name": "ataxin-7-like protein 1 isoform 1",
        "refseq_ac": "NP_065776",
        "gene_names_uniprotkb": "ATXN7L1; ATXN7L4; KIAA1218",
        "gene_names_refseq": "ATXN7L1; ATXN7L4",
        "protein_names_uniprotkb": "Ataxin-7-like protein 1; Ataxin-7-like protein 4",
        "protein_names_refseq": "ataxin 7-like 4; ataxin-7-like protein 1 isoform 1; ataxin-7-like protein 1; ataxin-7-like protein 4",
        "tax_id": 9606,
        "disease": "spinocerebellar ataxia 7 (Disease Ontology:DOID:0050958)",
        "pathway": " (hsa:222255)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;22544926;24715725;29351928;30379171;32387766;32488085;32897882;32938616;33912179;34509645;35051231;36241641",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D0Q2;B4DTS1;Q8N2T0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q9ULK2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86TG7-1",
        "uniprot_id": "PEG10_HUMAN",
        "mass": 80173.0,
        "length": 708,
        "protein_name": "Retrotransposon-derived protein PEG10",
        "gene_name": "PEG10",
        "organism": "Human",
        "refseq_name": "retrotransposon-derived protein PEG10 isoform 2",
        "refseq_ac": "NP_001035242",
        "gene_names_uniprotkb": "PEG10; EDR; KIAA1051e; MAR2; MART2; MEF3L1; RGAG3",
        "gene_names_refseq": "EDR; HB-1; MEF3L; Mar2; Mart2; PEG10; RGAG3; RTL2; SIRH1",
        "protein_names_uniprotkb": "Retrotransposon-derived protein PEG10; Embryonal carcinoma differentiation-regulated protein; MEF3-like protein 1; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein",
        "protein_names_refseq": "MEF3 like 1; Sushi-Ichi retrotransposon homolog 1; embryonal carcinoma differentiation regulated; mammalian retrotransposon-derived 2; mammalian retrotransposon-derived protein 2; myelin expression factor 3-like protein 1; paternally expressed gene 10 protein; retrotransposon Gag like 2; retrotransposon gag domain-containing protein 3; retrotransposon-derived gag-like polyprotein; retrotransposon-derived protein PEG10 isoform 2; retrotransposon-derived protein PEG10; ty3/Gypsy-like protein",
        "tax_id": 9606,
        "disease": "pre-eclampsia (Disease Ontology:DOID:10591)",
        "pathway": " (hsa:23089)",
        "pathway_count": 1,
        "publication_count": 98,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11318613;12620933;12810624;15611116;15767280;16423995;17050006;17369855;17621626;17942406;18625225;18669648;20068231;20084274;20362226;23481700;24397554;24715725;25418920;25469497;25576301;25645385;25880248;25892735;26024233;26154972;26235627;26811146;26929215;26992070;27600516;27846572;27920218;28063628;28193232;28218747;28228285;28514659;28649982;28832583;28834231;28904123;28992046;29093164;29242379;29331515;29393594;29437277;29508533;29557506;29632046;29632711;29769354;30094509;30315122;30379171;30397120;30410026;31154438;31217245;31844290;32157095;32357974;32387766;32488085;32502341;32938616;33141586;33214551;33298915;33592498;33633747;33691108;33717175;33912179;33936100;33968037;34019948;34087483;34171305;34211107;34357660;34413232;34932366;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36951542;37464405;37932427;37938771",
        "class_list": "",
        "function": "GPC3 and PEG10 peptides associated with placental gp96 elicit specific T cell immunity against hepatocellular carcinoma., [RefSeq, PubMed]; PEG10 contains two overlapping reading frames from which two proteins are translated by a -1 ribosomal frameshift mechanism., [RefSeq, PubMed]; PEG10 gene is imprinted, with preferential expression from the paternal allele., [RefSeq, PubMed]; Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia. Publication Status: Online-Only, [RefSeq, PubMed]; Programmed -1 ribosomal frameshifting in mouse and human Peg10 genes. Publication Status: Online-Only, [RefSeq, PubMed]; Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Study provides new data on the genomic organization as well as expression and translation of PEG10, a prerequisite in order to study and understand the role of PEG10 in cancer, embryonic development and normal cell homeostasis GeneRIF: Evidence for translation initiation from an in-frame, upstream non-AUG (CUG) codon, and from the downstream AUG, resulting in different isoforms. Publication Status: Online-Only, [RefSeq, PubMed]; The ORF1-2 protein of PEG10, synthesized utilizing the most efficient -1 frameshift mechanism yet documented in vivo, will have an essential function that is intrinsic to the importance of PEG10 in mammals, [RefSeq, PubMed]; This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]., [RefSeq]; UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DSP0;Q96A68;Q9UPV1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1903561 extracellular vesicle",
        "go_biological_process": "GO:0110077 vesicle-mediated intercellular transport;GO:0030154 cell differentiation;GO:0051260 protein homooligomerization;GO:0006915 apoptotic process;GO:0001890 placenta development",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "Q86TG7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P43155-1",
        "uniprot_id": "CACP_HUMAN",
        "mass": 70858.0,
        "length": 626,
        "protein_name": "Carnitine O-acetyltransferase",
        "gene_name": "CRAT",
        "organism": "Human",
        "refseq_name": "carnitine O-acetyltransferase isoform 2",
        "refseq_ac": "NP_001244292",
        "gene_names_uniprotkb": "CRAT; CAT1",
        "gene_names_refseq": "CAT1; CAT; CRAT; NBIA8",
        "protein_names_uniprotkb": "Carnitine O-acetyltransferase; 2.3.1.137; 2.3.1.7; CAT; Carnitine acetylase; Carnitine acetyltransferase; CrAT",
        "protein_names_refseq": "carnitine O-acetyltransferase isoform 2; carnitine acetylase",
        "tax_id": 9606,
        "disease": "Lambert-Eaton myasthenic syndrome (Disease Ontology:DOID:0050214); neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734); asthma (Disease Ontology:DOID:2841); myasthenia gravis (Disease Ontology:DOID:437); neurodegeneration with brain iron accumulation 8 (MONDO:MONDO:0054764)",
        "pathway": " (hsa:1384);  (R-HSA-389887);  (R-HSA-70895);  (R-HSA-9033241)",
        "pathway_count": 4,
        "publication_count": 141,
        "publication_id_list": "10022913;10092594;10486279;10562279;10673331;10832746;10947204;11013134;11060344;11060359;11101887;11181649;11237011;11264579;11406611;11546814;11738050;11781871;11931631;12269802;12359132;12434311;12456682;12559034;12562770;12578380;12696021;12717447;12885776;13416257;14752098;15060085;15099582;15166214;1527093;15342248;15545321;15576032;15599942;15858711;16023992;16141215;16385454;16756494;16854980;17007944;17371050;17726030;18359941;18712838;19197237;19208625;19584060;19608861;19632994;20178365;21554508;21976670;21980954;22002062;22057399;22291014;22371489;22747494;22956686;23485643;2351134;23963456;24235149;24449431;24865970;25016021;25538232;25576301;25854684;26086376;26138649;26220973;26251176;26344566;26992070;27597759;27600516;28521612;28611990;28765278;28787099;29395073;29671580;29741879;30429286;30779550;3082934;30833945;31154438;31435015;31448845;31844290;32157095;32502341;32938616;33537174;33968037;34171305;34185709;34405274;35051231;35154160;35580925;3597357;36010968;36241641;36413408;37828898;39302247;6928646;7356336;7649182;7719337;7790377;7829107;7945262;8387517;8824301;8824437;8858165;8902629;8943006;8991089;9089413;9090381;9090382;9090383;9165094;9214289;9271077;9539740;9653144;9668159;9837948;9889013",
        "class_list": "",
        "function": "CRAT missense variants cause abnormal carnitine acetyltransferase function in an early-onset case of Leigh syndrome., [RefSeq, PubMed]; Carnitine acetyltransferase deficiency mediates mitochondrial dysfunction-induced cellular senescence in dermal fibroblasts., [RefSeq, PubMed]; Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation (PubMed:15099582, PubMed:29395073). Responsible for the synthesis of short- and branched-chain acylcarnitines (PubMed:23485643). Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates (PubMed:23485643). Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates (PubMed:23485643)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes carnitine O-acetyltransferase, a member of the carnitine acyltransferase family and a key metabolic pathway enzyme which plays an important role in energy homeostasis and fat metabolism. This enzyme catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acyl-CoA/CoA. It is found in both the mitochondria and the peroxisome. Alternative splicing results in transcript variants encoding different isoforms that may localize to different subcellular compartments. [provided by RefSeq, Oct 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 5,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T952;Q9BW16",
        "ec_number_list": "3.6.1.-;3.6.1.77;3.1.2.2;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;2.3.1.42;1.3.3.6;2.3.2.27;1.1.1.42;1.11.1.6;3.4.24.56;1.4.3.3;2.6.1.51;2.6.1.44;2.3.1.176;2.3.1.16;2.3.1.155;2.3.1.21;2.3.2.36;1.14.13.39;4.1.3.4;2.3.1.137;2.3.1.7;5.3.3.21;2.3.1.65;3.4.21.-;1.5.3.13;3.4.21.53;3.1.2.22;1.4.3.1;1.1.1.184;1.3.1.38;1.3.1.124;1.1.3.15;1.5.3.1;1.5.3.7;5.1.99.4;4.1.2.63;1.2.3.5;2.5.1.18",
        "go_molecular_function": "GO:0003997 acyl-CoA oxidase activity;GO:0008458 carnitine O-octanoyltransferase activity;GO:0004092 carnitine O-acetyltransferase activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0016413 O-acetyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0046459 short-chain fatty acid metabolic process;GO:0051791 medium-chain fatty acid metabolic process;GO:0019254 carnitine metabolic process, CoA-linked;GO:0006635 fatty acid beta-oxidation",
        "synthesized_glycan_count": 0,
        "hit_score": 15.3,
        "record_id": "P43155-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75190-1",
        "uniprot_id": "DNJB6_HUMAN",
        "mass": 36087.0,
        "length": 326,
        "protein_name": "DnaJ homolog subfamily B member 6",
        "gene_name": "DNAJB6",
        "organism": "Human",
        "refseq_name": "dnaJ homolog subfamily B member 6 isoform b",
        "refseq_ac": "NP_005485",
        "gene_names_uniprotkb": "DNAJB6; HSJ2; MRJ; MSJ1",
        "gene_names_refseq": "DJ4; DNAJB6; DnaJ; HHDJ1; HSJ-2; HSJ2; LGMD1D; LGMD1E; LGMDD1; MRJ; MSJ-1",
        "protein_names_uniprotkb": "DnaJ homolog subfamily B member 6; HHDJ1; HSJ-2; Heat shock protein J2; MRJ; MSJ-1",
        "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 6; DnaJ-like 2 protein; dnaJ homolog subfamily B member 6 isoform b; dnaJ homolog subfamily B member 6; heat shock protein J2",
        "tax_id": 9606,
        "disease": "autosomal dominant limb-girdle muscular dystrophy (Disease Ontology:DOID:0110273); autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305)",
        "pathway": " (hsa:10049);  (R-HSA-3371453)",
        "pathway_count": 2,
        "publication_count": 96,
        "publication_id_list": "10319584;10954706;11237011;11747420;11896048;12750860;12853476;12917326;12974469;15364926;15802566;1586970;16278218;17081983;17322306;1754405;18235501;18235502;18550409;18669648;19229036;19413330;19914676;20068231;20159555;21406692;22334415;22366786;22465953;22541429;22735644;22940245;23186163;23349863;23481700;24397554;25418920;25505266;25576301;26154972;26375851;26758079;26811146;26992070;27397612;27846572;28233300;28904123;29242379;29437277;29493099;29557506;30410026;30429286;30484775;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32938616;32983136;33043033;33141586;33298915;33392160;33537174;33592498;33630763;33912179;33936100;33968037;34087483;34171305;34509645;34561969;34932366;35051231;35318648;35580925;36010968;36241641;36284347;37894814;37938771;38110916;38244155;7585962;8721986;8946918;9305631;9873016;9915854;9920933",
        "class_list": "",
        "function": "Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 (PubMed:10954706, PubMed:28233300). Plays an indispensable role in the organization of KRT8/KRT18 filaments (PubMed:10954706). Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin (PubMed:11896048, PubMed:22366786). Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (PubMed:20159555, PubMed:22366786). Also reduces cellular toxicity and caspase-3 activity (PubMed:11896048)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Human milk exosome-derived circDNAJB6 improves bronchopulmonary dysplasia model by promoting DNAJB6 gene transcription., [RefSeq, PubMed]; Isoform B but not isoform A inhibits huntingtin aggregation., [UniProtKB, PubMed, PubMed]; MiR-632 Induces DNAJB6 Inhibition Stimulating Endothelial-to-Mesenchymal Transition and Fibrosis in Marfan Syndrome Aortopathy. Publication Status: Online-Only, [RefSeq, PubMed]; The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D232;A8K7D8;A8KAG0;B4DN73;E9PCZ2;O95806;Q53EN8;Q59EF2;Q6FIC8;Q75MA2;Q9UIK6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:1900034 regulation of cellular response to heat;GO:0050877 nervous system process;GO:0032880 regulation of protein localization;GO:0006457 protein folding",
        "synthesized_glycan_count": 0,
        "hit_score": 9.7,
        "record_id": "O75190-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TC07-1",
        "uniprot_id": "TBC15_HUMAN",
        "mass": 79491.0,
        "length": 691,
        "protein_name": "TBC1 domain family member 15",
        "gene_name": "TBC1D15",
        "organism": "Human",
        "refseq_name": "TBC1 domain family member 15 isoform 3",
        "refseq_ac": "NP_001139685",
        "gene_names_uniprotkb": "TBC1D15",
        "gene_names_refseq": "RAB7-GAP; TBC1D15",
        "protein_names_uniprotkb": "TBC1 domain family member 15; GAP for RAB7; GTPase-activating protein RAB7; Rab7-GAP",
        "protein_names_refseq": "GAP for RAB7; GTPase-activating protein RAB7; TBC1 domain family member 15 isoform 3; Tre-2-budding uninhibited by benzimidazole-cell division cycle 16 domain, domain family member 15; Tre2/Bub2/Cdc16 domain family member 15",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64786);  (R-HSA-8854214)",
        "pathway_count": 2,
        "publication_count": 106,
        "publication_id_list": "10202141;11237011;16055087;16395330;16964243;17658474;17901050;18199687;18319245;18466115;18669648;18691976;19077034;19690332;20068231;20095038;20116244;20363736;20404108;21383079;21406692;21458671;22219378;22613832;22762500;22795129;22854040;23019362;23186163;23481700;23562278;24275569;24366607;24715725;25576301;25892735;26024233;26154972;26992070;27600516;27846572;27920218;28228285;28510447;28657654;28832583;28834231;29242379;29317506;29393594;29493099;29508533;29557506;29632711;29786170;30315122;30379171;30524438;30779550;31154438;31222486;31373491;31530632;31844290;31848261;32119511;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32555153;32897882;32938616;32938750;32983136;33141586;33298915;33392160;33592498;33936100;33968037;33981976;34171305;34211107;34357683;34509645;34561969;34725712;34932366;35051231;35251023;35254053;35513511;35580925;35705054;36010968;36241641;37217939;37340703;37777154;38409448;39531497;40914422",
        "class_list": "",
        "function": "A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission., [RefSeq, PubMed]; Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity)., [UniProtKB]; Although only TBC1D15/Rab7-GAP altered Rab7-GTP levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence, [RefSeq, PubMed]; NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. Erratum:[Exp Mol Med. 2024 Oct;56(10):2323. doi: 10.1038/s12276-024-01325-9. PMID: 39465353], [RefSeq, PubMed]; P53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]., [RefSeq]; This paper primarily describes mouse TBC1D15 but also reports the primary structure of human TBC1D15., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DMT9;B9A6L6;J3KNI9;Q9HA83",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0043087 regulation of GTPase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 11.2,
        "record_id": "Q8TC07-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P26640-1",
        "uniprot_id": "SYVC_HUMAN",
        "mass": 140476.0,
        "length": 1264,
        "protein_name": "Valine--tRNA ligase",
        "gene_name": "VARS1",
        "organism": "Human",
        "refseq_name": "valine--tRNA ligase",
        "refseq_ac": "NP_006286",
        "gene_names_uniprotkb": "VARS1; G7A; VARS2; VARS",
        "gene_names_refseq": "G7A; NDMSCA; VARS1; VARS2; VARS",
        "protein_names_uniprotkb": "Valine--tRNA ligase; 6.1.1.9; Protein G7a; ValRS; Valyl-tRNA synthetase",
        "protein_names_refseq": "protein G7a; valRS; valine tRNA ligase 1, cytoplasmic; valine--tRNA ligase; valyl-tRNA synthetase 2",
        "tax_id": 9606,
        "disease": "myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy (Disease Ontology:DOID:0070755); combined oxidative phosphorylation deficiency 20 (Disease Ontology:DOID:0111478); mitochondrial metabolism disease (Disease Ontology:DOID:700); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)",
        "pathway": " (hsa:7407);  (R-HSA-379716)",
        "pathway_count": 2,
        "publication_count": 117,
        "publication_id_list": "11237011;11347887;11714285;11829477;11858721;12690580;1373391;14656967;14660560;14671330;16055448;16408927;16429158;16906134;1761529;18083107;1898367;19608861;19651622;21654843;22223895;23186163;23481700;24715725;25418920;25505266;25576301;25645385;25892735;26154972;26375851;26539891;26758079;26992070;27846572;27862975;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29331515;29437277;29493099;29508533;29557506;29786170;30315122;30379171;30397120;30410026;30524438;31217245;31844290;32119511;32157095;32350084;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33465208;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34382495;34509645;34725712;35008409;35051231;35083852;35138101;35251023;35318648;35561310;36010968;36215666;36241641;37587064;37938771;38253038;38665916;38849541;39534244;40596516;40914422;4130389;6022858;656444;7118399;7654687;8052601;8078941;8188258;8428657;8449960;9278442;9421509;9431993",
        "class_list": "",
        "function": "Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]., [RefSeq]; Catalyzes the attachment of valine to tRNA(Val)., [UniProtKB, PubMed]; Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease., [RefSeq, PubMed]; High expression of VARS promotes the growth of multiple myeloma cells by causing imbalance in valine metabolism., [RefSeq, PubMed]; Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0V1N1;B4DZ61;Q5JQ90;Q96E77;Q9UQM2",
        "ec_number_list": "6.1.1.9",
        "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0004832 valine-tRNA ligase activity;GO:0005524 ATP binding;GO:0004812 aminoacyl-tRNA ligase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0006438 valyl-tRNA aminoacylation;GO:0006418 tRNA aminoacylation for protein translation",
        "synthesized_glycan_count": 0,
        "hit_score": 12.4,
        "record_id": "P26640-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13111-1",
        "uniprot_id": "CAF1A_HUMAN",
        "mass": 106910.0,
        "length": 956,
        "protein_name": "Chromatin assembly factor 1 subunit A",
        "gene_name": "CHAF1A",
        "organism": "Human",
        "refseq_name": "chromatin assembly factor 1 subunit A",
        "refseq_ac": "NP_005474",
        "gene_names_uniprotkb": "CHAF1A; CAF1P150; CAF",
        "gene_names_refseq": "CAF-1; CAF1B; CAF1P150; CAF1; CHAF1A; P150",
        "protein_names_uniprotkb": "Chromatin assembly factor 1 subunit A; CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; Chromatin assembly factor I p150 subunit; hp150",
        "protein_names_refseq": "CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; CTB-50L17.7; chromatin assembly factor 1 subunit A; chromatin assembly factor I (150 kDa); chromatin assembly factor I p150 subunit; hp150",
        "tax_id": 9606,
        "disease": "colon cancer (Disease Ontology:DOID:219); high grade glioma (Disease Ontology:DOID:3070); neuroblastoma (Disease Ontology:DOID:769); systemic lupus erythematosus (Disease Ontology:DOID:9074)",
        "pathway": " (hsa:10036)",
        "pathway_count": 1,
        "publication_count": 85,
        "publication_id_list": "10.1101/2023.09.13.557529;10052459;10648606;10893180;11237011;11250073;11296234;12697822;15302935;15327775;15882967;16964243;17081983;17525332;18212344;18220336;18452278;18669648;19413330;19651622;19664994;19664995;20068231;20562864;21406692;23186163;23301498;23481700;25114211;25218447;25802875;26728094;27600516;27869121;27920218;28218747;28228285;28514659;28832583;28834231;29242379;29393594;29493099;29508533;29557506;29786170;30379171;30779550;30784271;30849389;31217245;31222486;31530632;31844290;31848261;31937595;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32938616;33141586;33298915;33392160;33717175;33912179;33936100;34171305;34211107;34509645;35051231;35251023;35318648;35494241;35561310;35773729;36010968;36232396;37938771;38051950;40914422;7600578",
        "class_list": "",
        "function": "Aberrant SPOP-CHAF1A ubiquitination axis triggers tumor autophagy that endows a therapeutical vulnerability in diffuse large B cell lymphoma. Publication Status: Online-Only, [RefSeq, PubMed]; Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci., [UniProtKB, UniProtKB]; Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]., [RefSeq]; Inhibition of CAF-1 histone chaperone complex triggers cytosolic DNA and dsRNA sensing pathways and induces intrinsic immunity of hepatocellular carcinoma., [RefSeq, PubMed]; Unorthodox PCNA Binding by Chromatin Assembly Factor 1. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 40,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NXG5;Q7Z7K3;Q9UJY8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0051082 unfolded protein binding;GO:0070087 chromo shadow domain binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex;GO:0033186 CAF-1 complex",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0006334 nucleosome assembly;GO:0006335 DNA replication-dependent chromatin assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "Q13111-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13936-1",
        "uniprot_id": "CAC1C_HUMAN",
        "mass": 248977.0,
        "length": 2221,
        "protein_name": "Voltage-dependent L-type calcium channel subunit alpha-1C",
        "gene_name": "CACNA1C",
        "organism": "Human",
        "refseq_name": "voltage-dependent L-type calcium channel subunit alpha-1C isoform 18",
        "refseq_ac": "NP_000710",
        "gene_names_uniprotkb": "CACNA1C; CACH2; CACN2; CACNL1A1; CCHL1A1",
        "gene_names_refseq": "CACH2; CACN2; CACNA1C-IT2; CACNA1C; CACNL1A1; CCHL1A1; CaV1.2; LQT8; NEDHLSS; TS. LQT8; TS",
        "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2",
        "protein_names_refseq": "CACNA1C intronic transcript 2 (non-protein coding); CACNA1C intronic transcript 2; DHPR, alpha-1 subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; voltage-dependent L-type Ca2+ channel alpha 1 subunit; voltage-dependent L-type calcium channel subunit alpha-1C isoform 18",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Timothy syndrome (Disease Ontology:DOID:0060173); neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures (Disease Ontology:DOID:0070536); Brugada syndrome 3 (Disease Ontology:DOID:0110220); long QT syndrome 8 (Disease Ontology:DOID:0110649); Duchenne muscular dystrophy (Disease Ontology:DOID:11723)",
        "pathway": " (hsa:775);  (R-HSA-400042);  (R-HSA-419037);  (R-HSA-422356);  (R-HSA-5576892);  (R-HSA-5576893)",
        "pathway_count": 6,
        "publication_count": 187,
        "publication_id_list": "10.1101/2023.09.13.557529;10194514;10206966;10342826;10424882;10449730;10526167;10646604;10773014;10866047;10868950;10948191;11078440;11078469;11237011;11264248;11290418;11577798;11716850;11741969;11780755;11815450;11815460;11815462;11815463;11873862;12176756;12181424;12196472;12403834;12475777;12684222;12764427;12765789;12887316;1309946;1309948;1316612;1335957;13459201;14500339;14514350;15000524;15000528;15140941;15141227;15305887;15454078;15504896;15509562;15572341;15585596;15678092;15863612;15980432;16155576;16267048;16299511;16332676;16338416;16352729;16371464;16373322;16443778;1645720;16513675;1653763;16556766;16714477;16868246;17021801;17071743;17095603;17224476;17259518;17380317;17660294;17900700;17919183;18059411;18093912;18162464;18184654;18346985;1849000;18596924;18829456;19258039;19279214;19406745;19527072;19587354;20086079;20817017;20953164;21127204;21248752;21566136;2173707;21817159;22054663;22100296;22514276;22518098;23481700;23677916;23804213;23992284;24591645;24728418;25260352;25576301;25633834;25645385;25966690;26253506;26517901;26637798;26742847;27218670;2809592;28119464;28832583;29078335;29108130;29242379;29557506;29742403;29769354;29779930;30023270;30172029;30345660;30429286;30513141;30779550;31067468;31430211;31844290;31848261;32502341;32938616;34163037;35051231;3517644;35580925;36010968;37217939;37972591;38657895;38720004;39217481;3923453;6019353;6424440;6435940;7589840;7593639;7641683;7737988;7929812;7959794;8027028;8099279;8099908;8107964;8262246;8277227;8392192;8457197;8662784;8675920;8778232;8987985;8997178;9013606;9087614;9350615;9398268;9607315;9707174;9726229;9739505;9751501;9760042;9914469;9920805",
        "class_list": "",
        "function": "(Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930)., [UniProtKB, PubMed]; Effects of CACNA1C and ANK3 on cognitive function in patients with bipolar disorder., [RefSeq, PubMed]; NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia., [RefSeq, PubMed]; Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine., [RefSeq, PubMed]; This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]., [RefSeq]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; [CACNA1C rs58619945 genotype influences the cortical thickness of attention network among patients with Bipolar disorder]., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 73,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 6,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RUT3;E9PDJ0;Q13917;Q13918;Q13919;Q13920;Q13921;Q13922;Q13923;Q13924;Q13925;Q13926;Q13927;Q13928;Q13929;Q13930;Q13932;Q13933;Q14743;Q14744;Q15877;Q4VMI7;Q4VMI8;Q4VMI9;Q6PKM7;Q8N6C0;Q99025;Q99241;Q99875",
        "ec_number_list": "2.7.11.1",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0051393 alpha-actinin binding;GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential;GO:0005245 voltage-gated calcium channel activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0030425 dendrite",
        "go_biological_process": "GO:0045933 positive regulation of muscle contraction;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007507 heart development;GO:0086091 regulation of heart rate by cardiac conduction;GO:0035115 embryonic forelimb morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 19.3,
        "record_id": "Q13936-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UPM9-1",
        "uniprot_id": "B9D1_HUMAN",
        "mass": 22775.0,
        "length": 204,
        "protein_name": "B9 domain-containing protein 1",
        "gene_name": "B9D1",
        "organism": "Human",
        "refseq_name": "B9 domain-containing protein 1 isoform f",
        "refseq_ac": "NP_001308145",
        "gene_names_uniprotkb": "B9D1; MKSR1",
        "gene_names_refseq": "B9D1; B9; EPPB9; JBTS27; MKS9; MKSR-1; MKSR1",
        "protein_names_uniprotkb": "B9 domain-containing protein 1; MKS1-related protein 1",
        "protein_names_refseq": "B9 domain-containing protein 1 isoform f; B9 domain-containing protein 1; B9 protein domain 1; MKS1-related protein 1; endothelial precursor protein B9",
        "tax_id": 9606,
        "disease": "Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); Meckel syndrome 9 (Disease Ontology:DOID:0061294); Joubert syndrome 27 (Disease Ontology:DOID:0110996); nephronophthisis (Disease Ontology:DOID:12712)",
        "pathway": " (hsa:27077);  (R-HSA-5620912)",
        "pathway_count": 2,
        "publication_count": 58,
        "publication_id_list": "11237011;16357211;17574030;17646400;17719545;18037885;18337471;18694559;18801063;19004860;19081074;19208769;19940019;20230748;20308558;20399632;20558667;21273506;21422230;21493627;21548880;21565611;21620453;21725307;21792235;22179047;22433857;22653444;23141531;23141541;23253480;23348840;23400999;23530209;23747070;23769972;23789104;24053599;24089205;24231678;24469809;24886560;24982133;25047611;25313408;25418920;25576301;26477546;26992070;28904123;29437277;30315122;30410026;30429286;32726168;32938616;33968037;39894887",
        "class_list": "",
        "function": "B9D1 is a novel Meckel syndrome gene, [RefSeq, PubMed]; Ciliary transition zone localization.  Functions in a module with related proteins (MKS1 and B9D1) that cooperates with nephrocystins in ciliogenesis., [RefSeq, PubMed]; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Formation of the B9-domain protein complex MKS1-B9D2-B9D1 is essential as a diffusion barrier for ciliary membrane proteins., [RefSeq, PubMed]; MKS-1 and MKS-1-related proteins 1 and 2 (MKSR-1/EPPB9, MKSR-2/B9D2), localize to transition zones/basal bodies of sensory cilia; subcellular localization is largely co-dependent, pointing to a functional relationship between the proteins, [RefSeq, PubMed]; This gene encodes a B9 domain-containing protein, one of several that are involved in ciliogenesis. Alterations in expression of this gene have been found in a family with Meckel syndrome. Meckel syndrome has been associated with at least six different genes. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BU22",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008158 hedgehog receptor activity",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0005930 axoneme;GO:0036038 MKS complex",
        "go_biological_process": "GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:1904491 protein localization to ciliary transition zone;GO:0030030 cell projection organization",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q9UPM9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13287-1",
        "uniprot_id": "NMI_HUMAN",
        "mass": 35057.0,
        "length": 307,
        "protein_name": "N-myc-interactor",
        "gene_name": "NMI",
        "organism": "Human",
        "refseq_name": "N-myc-interactor",
        "refseq_ac": "NP_004679",
        "gene_names_uniprotkb": "NMI",
        "gene_names_refseq": "NMI",
        "protein_names_uniprotkb": "N-myc-interactor; N-myc and STAT interactor; Nmi",
        "protein_names_refseq": "N-myc-interactor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9111);  (R-HSA-9692916)",
        "pathway_count": 2,
        "publication_count": 106,
        "publication_id_list": "10779520;10950963;11237011;15208624;17035307;17270291;17412287;17596301;17761676;19054851;19380580;19398035;20068231;22046132;22253733;22312431;23186163;23483519;24509444;24622840;24714562;24715725;24854014;25135833;25502872;25505266;25576301;25764917;25907116;26154972;26320399;26342464;26375851;26378163;26728094;26992070;27164085;27203180;27397612;27543614;27846572;27862975;28063628;28148787;28228285;28467828;28514659;28832583;28834231;28855257;28904123;29038465;29242379;29294448;29350881;29377960;29493099;29557506;29632046;29632711;29786170;30185776;30315122;30379171;30429286;31034780;31092671;31154438;31217245;31231549;31844290;31848261;31998317;32157095;32350084;32387766;32502341;32728199;32897882;32938616;32983136;33060197;33141586;33592498;33691108;33781665;33912179;33968037;33981976;34362845;34433824;34561969;34932366;35051231;35494241;35580925;36010968;36241641;36284347;37846815;37938771;39125716;40596516;8668343;9781816;9989503",
        "class_list": "",
        "function": "Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881, PubMed:9989503). In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis (PubMed:29377960, PubMed:9989503). Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription (PubMed:9989503). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 (PubMed:10779520, PubMed:10950963). In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21 (PubMed:26342464). In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (By similarity). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion (PubMed:29038465). Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; IFP35 family proteins promote neuroinflammation and multiple sclerosis., [RefSeq, PubMed]; N-Myc and STAT Interactor is an Endometriosis Suppressor. Publication Status: Online-Only, [RefSeq, PubMed]; N-myc-interactor mediates microbiome induced epithelial to mesenchymal transition and is associated with chronic lung allograft dysfunction., [RefSeq, PubMed]; NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis., [RefSeq, PubMed]; NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5BU69;Q53TI8;Q8WTW2;Q9BVE5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045087 innate immune response;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0009615 response to virus;GO:0050729 positive regulation of inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 10.9,
        "record_id": "Q13287-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13490-1",
        "uniprot_id": "BIRC2_HUMAN",
        "mass": 69900.0,
        "length": 618,
        "protein_name": "Baculoviral IAP repeat-containing protein 2",
        "gene_name": "BIRC2",
        "organism": "Human",
        "refseq_name": "baculoviral IAP repeat-containing protein 2 isoform 1",
        "refseq_ac": "NP_001157",
        "gene_names_uniprotkb": "BIRC2; API1; MIHB; RNF48",
        "gene_names_refseq": "API1; BIRC2; HIAP2; Hiap-2; IAP-2; MIHB; RNF48; c-IAP1; cIAP1",
        "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 2; 2.3.2.27; C-IAP1; Cellular inhibitor of apoptosis 1; IAP homolog B; Inhibitor of apoptosis protein 2; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2; hIAP-2; hIAP2",
        "protein_names_refseq": "IAP homolog B; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2; apoptosis inhibitor 1; baculoviral IAP repeat-containing protein 2 isoform 1; baculoviral IAP repeat-containing protein 2; cellular inhibitor of apoptosis 1; inhibitor of apoptosis protein 2",
        "tax_id": 9606,
        "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); breast cancer (Disease Ontology:DOID:1612); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:329);  (R-HSA-111465);  (R-HSA-168638);  (R-HSA-168927);  (R-HSA-5213460);  (R-HSA-5357786);  (R-HSA-5357905);  (R-HSA-5357956);  (R-HSA-5668541);  (R-HSA-5675482);  (R-HSA-5676594);  (R-HSA-5689880);  (R-HSA-937041);  (R-HSA-9958825)",
        "pathway_count": 14,
        "publication_count": 323,
        "publication_id_list": "10085077;10200466;10224040;10329646;10359578;10404221;10444327;10453075;10490026;10521396;10702308;10797013;10837247;10982817;11087742;11098060;11106668;11181075;11237011;11278797;11313965;11427719;11460167;11463840;11566882;11577081;11728344;11741893;11853672;11923872;12107159;12167698;12374738;12514169;12527755;12529173;12571250;12668660;12709429;12721308;12721620;12787562;12791997;12796777;12887920;12917689;12917691;14514672;14633987;14661020;14716293;15024054;15053880;15064760;15084608;15258597;15327770;15368291;15585864;15620648;15644327;15665297;15814722;15824857;15870263;15916963;16115877;16123041;16214042;16260783;16282325;16547522;16603398;16682944;16829951;16829952;16901786;16953224;16964248;16983089;17047224;17290220;17297457;17303577;17314102;17443180;17496917;17562858;17636564;17644308;17702576;17873522;17980597;17981138;18079694;18082613;18172164;18178551;18414036;18467330;18555777;18570872;18632802;18635759;18636086;18669648;18846110;18997792;18997794;19015242;19135894;19153467;19188362;19241374;19278658;19289468;19363159;19398555;19416807;19424180;19426221;19524512;19524513;19535145;19815541;19838211;19874889;19910467;20005846;20096447;20185725;20219915;20228808;20300203;20304918;20368735;20385093;20385556;20483727;20501646;20651737;20888210;21081755;21091114;21145488;21235526;21239494;21362556;21408173;21447281;21549626;21571647;21596315;21653699;21659512;21737330;2183031;21849505;21931591;21962518;22029577;22036506;22085928;22095281;22117219;22128162;22179575;22216260;22265413;22297296;22421439;22435550;22817896;22848449;23159851;23313255;23395819;23453969;23481700;23486064;23667509;23746843;23824326;23825189;2405250;24056413;24059293;24098568;24246475;24248355;24260525;24298274;24316671;24323043;24432023;24493797;24556848;24703947;24714562;24726323;24726327;24813885;24896179;25152365;25197364;25305019;25418920;25486457;25505266;25565632;25576301;25578727;25645385;25681446;25852146;25880248;25996294;26154972;26344099;26728094;26758079;26775703;26866270;26900751;26933192;26992070;26997266;27307491;27458237;27545878;27552911;27591049;27846572;28317937;28506461;28661484;28904123;28920952;28920954;29493099;29557506;29642005;29681455;29883609;29883610;29930286;30146158;30361438;30379171;30420664;30770249;30988283;31031142;31138766;31217245;31358971;31366726;31511692;31844290;31848261;32157095;32269263;32320653;32350084;32357974;32387766;32502341;32561730;32938616;32983136;33141586;33298915;33469115;33912179;33981976;34162724;34211107;34215617;34363755;34509645;34876703;34999730;35051231;35580925;35941131;35985688;36215666;36241641;36788209;37938771;38253038;7510216;7512451;7531702;7544915;7578059;7639698;7667287;8140422;8234276;8521496;8548810;8552191;8626374;8643514;8662591;8662795;8663299;8702708;8976194;9049422;9065443;9122217;9247583;9252332;9325343;9367155;9430721;9431985;9718306;9744859;9852070;9973322",
        "class_list": "",
        "function": "BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Prognostic Significance of the BIRC2-BIRC3 Gene Signature in Head and Neck Squamous Cell Carcinoma., [RefSeq, PubMed]; The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E026;Q16516;Q4TTG0",
        "ec_number_list": "3.4.19.12;2.7.11.10;2.7.11.1;2.4.1.255;2.7.11.25;2.7.10.2;2.3.2.-;3.4.25.1;3.4.22.56;2.3.2.24;2.3.2.23;3.6.4.-;3.6.5.2;2.3.2.27;3.4.22.61;2.3.2.31;2.3.2.26",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0034121 regulation of toll-like receptor signaling pathway;GO:0042127 regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 32.8,
        "record_id": "Q13490-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y6H1-1",
        "uniprot_id": "CHCH2_HUMAN",
        "mass": 15513.0,
        "length": 151,
        "protein_name": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 2",
        "gene_name": "CHCHD2",
        "organism": "Human",
        "refseq_name": "coiled-coil-helix-coiled-coil-helix domain-containing protein 2 isoform 2 precursor",
        "refseq_ac": "NP_057223",
        "gene_names_uniprotkb": "CHCHD2; AAG10; C7orf17",
        "gene_names_refseq": "C7orf17; CHCHD2; MIX17B; MNRR1; NS2TP; PARK22",
        "protein_names_uniprotkb": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 2; Aging-associated gene 10 protein; HCV NS2 trans-regulated protein; NS2TP",
        "protein_names_refseq": "16.7kD protein; HCV NS2 trans-regulated protein; MIX17 homolog B; aging-associated gene 10 protein; coiled-coil-helix-coiled-coil-helix domain-containing protein 2 isoform 2 precursor; coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial; mitochondria nuclear retrograde regulator 1; mitochondrial nuclear retrograde regulator 1",
        "tax_id": 9606,
        "disease": "frontotemporal dementia and/or amyotrophic lateral sclerosis 2 (Disease Ontology:DOID:0060214); Parkinson's disease 22 (Disease Ontology:DOID:0080504); spinal muscular atrophy, Jokela type (Disease Ontology:DOID:0081356); Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:51142);  (R-HSA-1268020);  (R-HSA-9837999)",
        "pathway_count": 3,
        "publication_count": 101,
        "publication_id_list": "11237011;11923310;12198491;14623864;14726512;15254020;15522782;15644312;15683237;15870080;16115876;16185709;16849325;17101804;17297443;17510655;17579211;18174896;18678864;19409522;19453276;19680543;19767391;19841671;19962426;20112406;20593814;20877624;21750375;22262461;22710082;23041349;23201127;23303788;23481700;23597483;23811401;23931759;24315374;24520911;25315652;25418920;25476776;25505266;25576301;25645385;25662902;26067113;26154972;26375851;26504172;26561290;26697887;26758079;26923599;26992070;27496948;27642048;27862975;28377575;28396416;29301859;29557506;29932645;30120231;30429286;31217245;31327635;31695197;31844290;32157095;32265295;32488085;33141586;33257573;33298915;33691108;33936100;33968037;34171305;34211107;34357683;34433824;34704252;34932366;34943861;35051231;35154160;35318648;35580925;35870450;36010968;36241641;36284347;36629048;38395904;38453793;38750212;39174523;7623837;7743181",
        "class_list": "",
        "function": "Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Findings establish CHCHD2, a previously uncharacterized small mitochondrial protein with no known homology to the Bcl-2 family, as one of the negative regulators of mitochondria-mediated apoptosis., [RefSeq, PubMed]; Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson's disease phenotypes in vivo and in cell models. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction., [RefSeq, PubMed]; MNRR1 (formerly CHCHD2) is imported to the mitochondrial intermembrane space by a Mia40-mediated pathway, where it binds to cytochrome c oxidase (COX)., [RefSeq, PubMed]; Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Silencing CHCHD2 reduces cellular oxygen consumption and disrupts the assembly and activity of Cytochrome C Oxidase. Erratum:[PLoS Genet. 2010;6(3). doi: 10.1371/annotation/36fe7624-0904-46d4-a013-4be6195245c4], [RefSeq, PubMed]; The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]., [RefSeq]; Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q498C3;Q6NZ50",
        "ec_number_list": "",
        "go_molecular_function": "GO:0043565 sequence-specific DNA binding;GO:0140297 DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034599 cellular response to oxidative stress;GO:0007005 mitochondrion organization;GO:1900037 regulation of cellular response to hypoxia",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "Q9Y6H1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43602-1",
        "uniprot_id": "DCX_HUMAN",
        "mass": 40574.0,
        "length": 365,
        "protein_name": "Neuronal migration protein doublecortin",
        "gene_name": "DCX",
        "organism": "Human",
        "refseq_name": "neuronal migration protein doublecortin isoform a",
        "refseq_ac": "NP_000546",
        "gene_names_uniprotkb": "DCX; DBCN; LISX",
        "gene_names_refseq": "DBCN; DCX; DC; LISX; SCLH; XLIS",
        "protein_names_uniprotkb": "Neuronal migration protein doublecortin; Doublin; Lis-X; Lissencephalin-X",
        "protein_names_refseq": "doublecortex; doublin; lis-X; lissencephalin-X; neuronal migration protein doublecortin isoform a; neuronal migration protein doublecortin",
        "tax_id": 9606,
        "disease": "lissencephaly (Disease Ontology:DOID:0050453); subcortical band heterotopia (Disease Ontology:DOID:0111169); X-linked lissencephaly 1 (Disease Ontology:DOID:0112239); hypertension (Disease Ontology:DOID:10763); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); McCune Albright syndrome (Disease Ontology:DOID:1858); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); brain infarction (Disease Ontology:DOID:3454); dyslexia (Disease Ontology:DOID:4428); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:1641);  (R-HSA-447043)",
        "pathway_count": 2,
        "publication_count": 41,
        "publication_id_list": "10369164;10441340;10807542;11152476;11175293;11237011;11468322;11601509;12027577;12390976;12552055;12692530;14741102;14741103;15099191;15345747;15632197;17081983;20715151;21159948;22359282;22367209;24607389;27292316;29557506;31844290;31848261;32050972;35213059;35580925;38791543;39191219;8922386;9371782;9489699;9489700;9618162;9668176;9804856;9817918;9989615",
        "class_list": "",
        "function": "Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration., [UniProtKB, PubMed]; Novel lissencephaly-associated DCX variants in the C-terminal DCX domain affect microtubule binding and dynamics., [RefSeq, PubMed]; Phenotypic Variability in Novel Doublecortin Gene Variants Associated with Subcortical Band Heterotopia. Publication Status: Online-Only, [RefSeq, PubMed]; Reconsidering Neurogenetic Indication in the Human Brain: Broad Expression of Doublecortin Transcript in the Hippocampal and Cortical Cell Populations., [RefSeq, PubMed]; This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 34,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 13,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NFY6;A9Z1V8;D3DUY8;D3DUY9;D3DUZ0;O43911;Q5JYZ5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005874 microtubule;GO:0043005 neuron projection;GO:0005875 microtubule associated complex",
        "go_biological_process": "GO:0007399 nervous system development;GO:0035556 intracellular signal transduction;GO:0001764 neuron migration;GO:0007417 central nervous system development;GO:0060041 retina development in camera-type eye",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "O43602-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13561-1",
        "uniprot_id": "DCTN2_HUMAN",
        "mass": 44231.0,
        "length": 401,
        "protein_name": "Dynactin subunit 2",
        "gene_name": "DCTN2",
        "organism": "Human",
        "refseq_name": "dynactin subunit 2 isoform 2",
        "refseq_ac": "NP_001248341",
        "gene_names_uniprotkb": "DCTN2; DCTN50",
        "gene_names_refseq": "DCTN2; DCTN50; DYNAMITIN; HEL-S-77; RBP50",
        "protein_names_uniprotkb": "Dynactin subunit 2; 50 kDa dynein-associated polypeptide; DCTN-50; Dynactin complex 50 kDa subunit; p50 dynamitin",
        "protein_names_refseq": "50 kDa dynein-associated polypeptide; dynactin 2 (p50); dynactin complex 50 kDa subunit; dynactin subunit 2 isoform 2; epididymis secretory protein Li 77; epididymis secretory sperm binding protein; p50 dynamitin",
        "tax_id": 9606,
        "disease": "synucleinopathy (Disease Ontology:DOID:0050890); retinal degeneration (Disease Ontology:DOID:8466)",
        "pathway": " (hsa:10540);  (R-HSA-2132295);  (R-HSA-2565942);  (R-HSA-3371497);  (R-HSA-380259);  (R-HSA-380270);  (R-HSA-380284);  (R-HSA-380320);  (R-HSA-5620912);  (R-HSA-6807878);  (R-HSA-6811436);  (R-HSA-8854518)",
        "pathway_count": 12,
        "publication_count": 392,
        "publication_id_list": "10036229;10052452;10064083;10072072;10226031;10318838;10359595;10445031;10480952;10540230;10559959;10559986;10562278;10593899;10631941;10631952;10639150;10679020;10747884;10748235;10761932;10809954;10903204;10921873;11035033;11076968;11080672;11172815;11237011;11285137;11306556;11461920;11483508;11529500;11589254;11684289;11689559;11701661;11703931;11726511;11748249;11751894;11790530;11813165;11853874;11956313;12047556;12070132;12078484;12198549;12207013;12221128;12364337;12388752;12401177;12432908;12447383;12634853;12665801;12742663;12748383;12781197;12852856;12925777;13486053;13678582;14580337;14654841;14654843;14731593;14742712;1493716;15037235;15144186;15159550;15381148;15483056;15498487;15591061;15616190;15632110;15705883;15728195;15749704;15813748;15878873;15911768;15914536;16030262;16181339;16207721;16242130;1631136;16314391;16357211;16403413;16462731;16618111;16633337;16723730;1680566;16824007;16890155;16912714;16926190;16940185;17142755;17253781;17274799;17283181;17360540;17429068;17451557;17488286;17574030;17591767;17646400;17719545;17760859;17804755;17827179;17927562;17956946;18037885;18046453;18086915;18182008;18215318;18243712;18254226;18283113;18292509;18378770;18477460;18521620;18524849;18566290;18615013;18635947;18641641;18664496;18694559;18801063;18809720;1898986;19004860;19015319;19081074;19109418;19164740;19296914;19359544;1956401;19564404;1957170;19631211;19635840;19690332;19753100;19758564;19940019;20006655;20038533;20072699;20230748;20308558;20357002;20399632;20420828;20427317;20558667;20637885;20682791;20978158;21116285;21158691;21173190;21183720;2121367;21219331;21273506;21347367;21376746;21422230;21441454;21548880;21565611;21620453;21689688;21700222;21725307;21792235;21796517;21844168;2190094;22011577;22013193;22094269;22094468;22130221;22179047;22266222;22304919;22318716;22365832;22433123;22433857;22562055;22641346;22653444;22791416;22898188;22905912;23141531;23141541;23186163;23253480;23301498;23333653;23348840;23400999;23481700;23530209;23747070;23769972;23783758;23789104;23839779;2391366;23921553;24012426;24053599;24089205;24119662;24231678;24469809;24694367;24714562;24715725;24806965;24891604;24982133;25047611;25233431;25313408;25418920;25436559;25453831;25492864;25532896;25576301;25645385;25880248;26073023;26154972;26203193;26313416;26992070;27462449;27600516;27663436;27846572;28083797;28301631;28510447;28755533;28904123;28919297;29493099;29557506;30197098;30315122;30429286;31110491;31141847;31154438;31222486;31530632;31731497;31826031;31844290;31848261;31998317;32016915;32157095;32161166;32320027;32350084;32357974;32387766;32448030;32488085;32502341;32544881;32897882;32938616;32982970;32983136;33123756;33141586;33214551;33298915;33402344;33592498;33691108;33912179;33936100;33968037;33981976;34019948;34080666;34087483;34171305;34357683;34405274;34433824;34509645;34932366;35051231;35154160;35318648;35580925;36010968;36241641;38665916;38842133;39534244;40914422;6645495;6891012;7481823;7592972;7650016;7667286;7691276;7769006;7790358;8001155;8046351;8128252;8132710;8134367;8145819;8148318;8157723;8221884;8253837;8282004;8313912;8397411;8415765;8505331;8560673;8620540;8636227;8642258;8647893;8687433;8838651;8849454;8909537;8939989;8947036;8991093;9030515;9050864;9075930;9114004;9150144;9177194;9202021;9244307;9288971;9311912;9312039;9323141;9380700;9382863;9405360;9464360;9464361;9490716;9497313;9539769;9545226;9606180;9667968;9671725;9671731;9733780;9751720;9990005",
        "class_list": "",
        "function": "Binding between ROCK1 and DCTN2 triggers diabetesassociated centrosome amplification in colon cancer cells., [RefSeq, PubMed]; Pan-cancer analysis of DCTN2 and its tumour-promoting role in HCC by modulating the AKT pathway., [RefSeq, PubMed]; Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBK5;Q86YN2;Q9BW17",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0030507 spectrin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016020 membrane",
        "go_biological_process": "GO:0007080 mitotic metaphase chromosome alignment;GO:0007052 mitotic spindle organization;GO:0071539 protein localization to centrosome;GO:0007017 microtubule-based process",
        "synthesized_glycan_count": 0,
        "hit_score": 39.7,
        "record_id": "Q13561-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P43026-1",
        "uniprot_id": "GDF5_HUMAN",
        "mass": 55395.0,
        "length": 501,
        "protein_name": "Growth/differentiation factor 5",
        "gene_name": "GDF5",
        "organism": "Human",
        "refseq_name": "growth/differentiation factor 5 preproprotein",
        "refseq_ac": "NP_000548",
        "gene_names_uniprotkb": "GDF5; BMP14; CDMP1",
        "gene_names_refseq": "BDA1C; BMP-14; BMP14; CDMP1; DUPANS; GDF5; LAP-4; LAP4; OS5; SYM1B; SYNS2",
        "protein_names_uniprotkb": "Growth/differentiation factor 5; BMP-14; Bone morphogenetic protein 14; CDMP-1; Cartilage-derived morphogenetic protein 1; GDF-5; LAP-4; LPS-associated protein 4; Lipopolysaccharide-associated protein 4; Radotermin",
        "protein_names_refseq": "LPS-associated protein 4; bone morphogenetic protein 14; cartilage-derived morphogenetic protein-1; growth/differentiation factor 5 preproprotein; lipopolysaccharide-associated protein 4; radotermin",
        "tax_id": 9606,
        "disease": "fibular hypoplasia and complex brachydactyly (Disease Ontology:DOID:0050790); multiple synostoses syndrome (Disease Ontology:DOID:0050794); developmental dysplasia of the hip 1 (Disease Ontology:DOID:0060931); acromesomelic dysplasia, Hunter-Thompson type (Disease Ontology:DOID:0080051); acromesomelic dysplasia, Grebe type (Disease Ontology:DOID:0080052); proximal symphalangism 2 (Disease Ontology:DOID:0080788); multiple synostoses syndrome 1 (Disease Ontology:DOID:0081317); multiple synostoses syndrome 2 (Disease Ontology:DOID:0081318); brachydactyly type A1 (Disease Ontology:DOID:0110964); brachydactyly type A2 (Disease Ontology:DOID:0110965); brachydactyly type C (Disease Ontology:DOID:0110970); brachydactyly type A1C (Disease Ontology:DOID:0110977); Parkinson's disease (Disease Ontology:DOID:14330); osteoarthritis (Disease Ontology:DOID:8398); osteoarthritis susceptibility 5 (MONDO:MONDO:0012893)",
        "pathway": " (hsa:8200);  (R-HSA-2129379)",
        "pathway_count": 2,
        "publication_count": 49,
        "publication_id_list": "10025398;10424889;10544250;10646116;10930463;11276205;11970960;12121354;12358597;12415008;12429738;1400330;14701737;14735582;15530414;16127465;16222676;16532400;16892395;1708799;17324935;17384641;18184661;18203755;18283415;18339631;18446792;18629880;19229295;19956691;20683927;21646718;21976273;22828468;24098149;25092592;25820810;26643732;35563063;36823651;37817264;37895244;7500359;7534784;7961761;7980526;8589725;9288098;9725916",
        "class_list": "",
        "function": "Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:15530414, PubMed:21976273, PubMed:24098149, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Influence of Different Evolutive Forces on GDF5 Gene Variability. Publication Status: Online-Only, [RefSeq, PubMed]; LINC00313 promotes the proliferation and inhibits the apoptosis of chondrocytes via regulating miR-525-5p/GDF5 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. [provided by RefSeq, Aug 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 15,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P5Q2;Q96SB1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0036122 BMP binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007267 cell-cell signaling;GO:0045666 positive regulation of neuron differentiation;GO:0050680 negative regulation of epithelial cell proliferation;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0043524 negative regulation of neuron apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "P43026-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IVS8-1",
        "uniprot_id": "GLCTK_HUMAN",
        "mass": 55253.0,
        "length": 523,
        "protein_name": "Glycerate kinase",
        "gene_name": "GLYCTK",
        "organism": "Human",
        "refseq_name": "glycerate kinase isoform 2",
        "refseq_ac": "NP_001138423",
        "gene_names_uniprotkb": "GLYCTK; HBEBP4; LP5910",
        "gene_names_refseq": "GLYCTK; HBEBP2; HBEBP4; HBeAgBP4A",
        "protein_names_uniprotkb": "Glycerate kinase; 2.7.1.31; HBeAg-binding protein 4",
        "protein_names_refseq": "HBeAg binding protein 4; HBeAg-binding protein 2; glycerate kinase isoform 2",
        "tax_id": 9606,
        "disease": "D-glyceric aciduria (Disease Ontology:DOID:0111626)",
        "pathway": " (hsa:132158);  (R-HSA-70350)",
        "pathway_count": 2,
        "publication_count": 47,
        "publication_id_list": "11237011;11679716;12941785;13093749;15498874;16266770;16289032;16753811;19237742;20800603;20841500;20949620;22098443;22371574;23444097;24275569;24289155;24569995;2537226;25892735;27846572;27920218;28190537;28467828;28855257;29242379;29508533;29557506;30637540;31154438;31837836;31844290;32502341;33141586;33298915;33936100;34087483;35580925;39619776;41330740;4688871;5353106;5777313;7833921;805723;8535439;9610797",
        "class_list": "",
        "function": "Identification of two variants of the human glycerate kinase gene-Glycerate kinase 1 (GLYCTK1), longer variant, and Glycerate kinase 2 (GLYCTK2), shorter variant., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0P630;Q2EZ43;Q6Y2K6;Q7Z6G5;Q86YR8;Q8TED2;Q8WTY2",
        "ec_number_list": "2.7.1.31",
        "go_molecular_function": "GO:0008887 glycerate kinase activity;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q8IVS8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y223-1",
        "uniprot_id": "GLCNE_HUMAN",
        "mass": 79275.0,
        "length": 722,
        "protein_name": "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase",
        "gene_name": "GNE",
        "organism": "Human",
        "refseq_name": "bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1",
        "refseq_ac": "NP_001121699",
        "gene_names_uniprotkb": "GNE; GLCNE; IBM2",
        "gene_names_refseq": "DMRV; GLCNE; GNE; IBM2; NM; THC12; Uae1",
        "protein_names_uniprotkb": "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; ManAc kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-GlcNAc-2-epimerase; Uridine diphosphate-N-acetylglucosamine-2-epimerase",
        "protein_names_refseq": "N-acylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase",
        "tax_id": 9606,
        "disease": "GNE myopathy (Disease Ontology:DOID:0080718); thrombocytopenia (Disease Ontology:DOID:1588); sialuria (Disease Ontology:DOID:3659); thrombocytopenia 12 with or without myopathy (MONDO:MONDO:0958325)",
        "pathway": " (hsa:10020);  (R-HSA-4085001);  (R-HSA-4085011)",
        "pathway_count": 3,
        "publication_count": 132,
        "publication_id_list": "10191093;10206952;10330343;10334995;10356312;10405317;10431835;10504389;10536037;10581036;10742600;10749855;10861246;10947946;11062056;11237011;11279095;11326336;11528398;11602804;11751519;11916006;12177386;12235148;12325084;12409274;12473753;12473769;12473780;12497639;12603328;12668675;12743242;12811782;12913203;12921793;14707127;14962670;15136692;15146476;15213228;15501818;15576474;16147865;16237198;16372135;16503651;17123352;1756715;17597614;18632803;18815882;19797320;19841673;20068231;21081508;22343627;22692205;2443758;24715725;25257349;25418920;25576301;26980148;26992070;27535533;27600516;27862975;27920218;2808337;28218747;28228285;28832583;28904123;29242379;29393594;29437277;29493099;29557506;29786170;29789417;30171045;30315122;30429286;30573663;30833945;31154438;3136930;31530632;31844290;31848261;32157095;32265295;32387766;32488085;32502341;32897882;32938616;33141586;33198675;33298915;33592498;33633747;33912179;33968037;34087483;34171305;34357683;34509645;34788986;34858435;34932366;35051231;35052006;35561310;35580925;36215666;36284347;38237079;7252518;7559389;8333853;8439453;8591035;8611500;8631981;8920913;8985184;9010752;9199191;9822625;9826427",
        "class_list": "glycogene",
        "function": "Bifunctional enzyme that possesses both UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities, and serves as the initiator of the biosynthetic pathway leading to the production of N-acetylneuraminic acid (NeuAc), a critical precursor in the synthesis of sialic acids. By catalyzing this pivotal and rate-limiting step in sialic acid biosynthesis, this enzyme assumes a pivotal role in governing the regulation of cell surface sialylation, playing a role in embryonic angiogenesis (PubMed:10334995, PubMed:11326336, PubMed:14707127, PubMed:16503651, PubMed:2808337, PubMed:38237079). Sialic acids represent a category of negatively charged sugars that reside on the surface of cells as terminal components of glycoconjugates and mediate important functions in various cellular processes, including cell adhesion, signal transduction, and cellular recognition (PubMed:10334995, PubMed:14707127)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Expression studies indicate that GNE has a tissue-specific splice pattern, with four splice variants., [RefSeq, PubMed]; The crystal structure of the kinase domain of GNE provides a structural basis for understanding disease-causing mutations and a model of hexameric wild type full length enzyme Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]; These data therefore suggest a role of GNE1 in basic supply of cells with sialic acids, whereas splice variants GNE2 and GNE3 may have a function in fine-tuning of the sialic acid pathway., [RefSeq, PubMed]; Two novel isoforms of human GNE, namely GNE2 and GNE3, which possess extended and deleted N-termini, respectively, were characterized., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 828,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6PZH2;A6PZH3;A7UNU7;B2R6E1;B7Z372;B7Z428;D3DRP7;F5H499;H0YFA7;Q0VA94",
        "ec_number_list": "2.7.1.60;3.2.1.183",
        "go_molecular_function": "GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity;GO:0009384 N-acylmannosamine kinase activity;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0005524 ATP binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0006045 N-acetylglucosamine biosynthetic process;GO:0006055 CMP-N-acetylneuraminate biosynthetic process;GO:0046380 N-acetylneuraminate biosynthetic process;GO:0006047 UDP-N-acetylglucosamine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.3,
        "record_id": "Q9Y223-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y283-1",
        "uniprot_id": "INVS_HUMAN",
        "mass": 117826.0,
        "length": 1065,
        "protein_name": "Inversin",
        "gene_name": "INVS",
        "organism": "Human",
        "refseq_name": "inversin isoform a",
        "refseq_ac": "NP_055240",
        "gene_names_uniprotkb": "INVS; INV; NPHP2",
        "gene_names_refseq": "INVS; INV; NPH2; NPHP2",
        "protein_names_uniprotkb": "Inversin; Inversion of embryo turning homolog; Nephrocystin-2",
        "protein_names_refseq": "inversin isoform a; inversion of embryo turning homolog; inversion of embryonic turning; nephrocystin-2",
        "tax_id": 9606,
        "disease": "ciliopathy (Disease Ontology:DOID:0060340); nephronophthisis 2 (Disease Ontology:DOID:0111113); hypertension (Disease Ontology:DOID:10763); tetralogy of Fallot (Disease Ontology:DOID:6419)",
        "pathway": " (hsa:27130)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "11935322;11941489;12872123;15852005;18371931;21565611;23186163;23481700;23793029;25576301;25645385;26154972;26992070;27220846;27846572;29557506;30315122;30429286;30524438;30598432;30779550;31154438;31844290;31848261;31895004;32157095;32335886;32357974;32387766;32897882;32938616;33141586;33298915;33392160;33592498;33912179;33936100;33968037;33981976;34087483;34171305;34509645;35051231;35254053;35580925;36010968;36215666;37938771;39894887",
        "class_list": "",
        "function": "Fetus diagnosed with type II nephronophthisis had a heterozygous c.100+1G>A variant and deletion of exon 3 of the INVS gene, [RefSeq, PubMed]; Has conserved ankyrin repeat and IQ domains and interacts with calmodulin, [RefSeq, PubMed]; Inversin required for ciliary translocation of Smo and activation of the Shh pathway; Shh signaling promotes inversin phosphorylation by PKA and inversin-Smo interaction, [RefSeq, PubMed]; Novel fibrillar structure in the inversin compartment of primary cilia revealed by 3D single-molecule superresolution microscopy., [RefSeq, PubMed]; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity)., [UniProtKB, PubMed, PubMed]; This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A2Y2;Q2NKL0;Q5W0T6;Q8IVX8;Q9BRB9;Q9Y488;Q9Y498",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule;GO:0005929 cilium",
        "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0001822 kidney development;GO:0016055 Wnt signaling pathway;GO:1904108 protein localization to ciliary inversin compartment",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q9Y283-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NG31-1",
        "uniprot_id": "KNL1_HUMAN",
        "mass": 265391.0,
        "length": 2342,
        "protein_name": "Outer kinetochore KNL1 complex subunit KNL1",
        "gene_name": "KNL1",
        "organism": "Human",
        "refseq_name": "outer kinetochore KNL1 complex subunit KNL1 isoform 2",
        "refseq_ac": "NP_653091",
        "gene_names_uniprotkb": "KNL1; CASC5; KIAA1570",
        "gene_names_refseq": "AF15Q14; CASC5; CT29; D40; KNL1; MCPH4; PPP1R55; Spc7; hKNL-1; hSpc105",
        "protein_names_uniprotkb": "Outer kinetochore KNL1 complex subunit KNL1; AF15q14; ALL1-fused gene from chromosome 15q14 protein; Blinkin; Bub-linking kinetochore protein; CT29; Cancer susceptibility candidate gene 5 protein; Cancer/testis antigen 29; Kinetochore scaffold 1; Kinetochore-null protein 1; Protein CASC5; Protein D40/AF15q14",
        "protein_names_refseq": "ALL1-fused gene from chromosome 15q14 protein; blinkin, bub-linking kinetochore protein; cancer susceptibility candidate 5; cancer susceptibility candidate gene 5 protein; cancer/testis antigen 29; kinetochore null 1 homolog; kinetochore-null protein 1; microcephaly, primary autosomal recessive 4; outer kinetochore KNL1 complex subunit KNL1 isoform 2; outer kinetochore KNL1 complex subunit KNL1; protein phosphatase 1, regulatory subunit 55",
        "tax_id": 9606,
        "disease": "primary autosomal recessive microcephaly 4 (Disease Ontology:DOID:0070291); autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296); primary microcephaly (Disease Ontology:DOID:0070297); sarcoma (Disease Ontology:DOID:1115)",
        "pathway": " (hsa:57082);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5663220);  (R-HSA-606279);  (R-HSA-68877);  (R-HSA-9648025)",
        "pathway_count": 9,
        "publication_count": 227,
        "publication_id_list": "10.1101/2023.09.13.557529;10411507;10600384;10678165;10958683;10980622;11081627;11181178;11237011;11371342;11509732;11535616;11804586;12006501;12087463;12194817;12429848;12577064;12618766;12618768;12679384;12732141;12805219;12852857;14730319;15006353;15085137;15339662;15369671;15502821;15507212;15579588;15723797;15737063;15864301;15866170;15944396;16292343;16439214;16541025;16622419;16622420;16682347;16890222;16943183;17030981;17112726;17113138;17129783;17196341;17198702;17199038;17339379;1737036;17981135;18001770;18045986;18097444;18669648;18691976;18716626;18923426;18987736;19350017;19398759;19410544;19410545;19450515;19690332;19696148;19815554;19893618;19965387;20030946;20068231;20080577;20101212;20231385;20471944;20566683;20591975;20819937;21111234;21148482;21199919;21397845;21576392;21768289;21868368;21878504;21987589;22000412;22094460;22201036;22275430;22331848;22608513;22645359;22660415;22790947;22885700;22983954;23186163;23222643;23481700;23801653;24366607;24397554;24530301;24714562;24715725;24914801;24958902;25308863;25418920;25576301;25645385;25740311;25789526;25802875;26154972;26345214;26375851;26621532;26626498;26728094;26758079;26811146;26929215;26992070;27149178;27600516;27697923;27846572;27881301;27920218;28063628;28218747;28228285;28441529;28510447;28514659;28649982;28832583;28834231;28904123;29142109;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30059200;30100357;30315122;30379171;30410026;30484775;30524438;30779550;30833945;31154438;31217245;31409757;31530632;31844290;31848261;31937595;31998317;32027339;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34260926;34433824;34509645;34932366;35051231;35132862;35254053;35318648;35561310;35580925;35705054;36010968;36215666;36241641;37217939;37937525;37938771;38459127;38459128;38583438;39302247;39531497;39534244;40136647;40307207;40596516;9649308;9649503;9892021",
        "class_list": "",
        "function": "A new cancer/testis gene frequently expressed in lung cancer of smokers, [RefSeq, PubMed]; A novel KNL1 intronic splicing variant likely destabilizes the KMN complex, causing primary microcephaly., [RefSeq, PubMed]; AF15q14 seems identical to an mRNA previously found to be expressed in melanoma rendered nontumorigenic by microcell-mediated introduction of normal chromosome 6, suggesting the gene may function normally to suppress cell growth and/or enhance maturation., [RefSeq, PubMed]; Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Kinetochore scaffold 1 downregulation suppressed the development of non-small cell lung cancer by inactivating the phosphatidylinositol 3 kinase/protein kinase B (AKT)/nuclear factor-kappa B pathway., [RefSeq, PubMed]; The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 15,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 15,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 15,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 24,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 4,
        "glyco_site_count": 19,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NHE1;Q8WXA6;Q9HCK2;Q9NR92",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0001669 acrosomal vesicle",
        "go_biological_process": "GO:0031619 homologous chromosome orientation in meiotic metaphase I;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0001675 acrosome assembly;GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint",
        "synthesized_glycan_count": 0,
        "hit_score": 24.8,
        "record_id": "Q8NG31-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P86479-1",
        "uniprot_id": "PR20C_HUMAN",
        "mass": 23262.0,
        "length": 221,
        "protein_name": "Proline-rich protein 20C",
        "gene_name": "PRR20C",
        "organism": "Human",
        "refseq_name": "proline-rich protein 20B",
        "refseq_ac": "NP_001123876",
        "gene_names_uniprotkb": "PRR20C",
        "gene_names_refseq": "PRR20B",
        "protein_names_uniprotkb": "Proline-rich protein 20C",
        "protein_names_refseq": "proline-rich protein 20B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:122183);  (hsa:729233);  (hsa:729240);  (hsa:729246);  (hsa:729250)",
        "pathway_count": 5,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N7V5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P86479-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q149N8-1",
        "uniprot_id": "SHPRH_HUMAN",
        "mass": 193079.0,
        "length": 1683,
        "protein_name": "E3 ubiquitin-protein ligase SHPRH",
        "gene_name": "SHPRH",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase SHPRH isoform a",
        "refseq_ac": "NP_001036148",
        "gene_names_uniprotkb": "SHPRH; KIAA2023",
        "gene_names_refseq": "RAD5; SHPRH; bA545I5.2",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SHPRH; 2.3.2.27; 3.6.4.-; RING-type E3 ubiquitin transferase SHPRH; SNF2, histone-linker, PHD and RING finger domain-containing helicase",
        "protein_names_refseq": "2610103K11Rik; E3 ubiquitin-protein ligase SHPRH isoform a; E3 ubiquitin-protein ligase SHPRH; RING-type E3 ubiquitin transferase SHPRH; SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase; SNF2, histone-linker, PHD and RING finger domain-containing helicase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:257218);  (R-HSA-8866654)",
        "pathway_count": 2,
        "publication_count": 95,
        "publication_id_list": "10562279;11237011;11740563;12837266;15215855;15215856;16307923;16868077;17108083;17130289;17726030;18316726;18359941;18719106;19208625;19410543;19723507;21203937;21248752;21329877;21396873;21406692;21554508;22021426;23481700;24662292;24807418;24979766;25030448;25170678;25505266;25576301;25645385;25880248;25936802;26086376;26210183;26216882;26344566;26350214;26711259;26992070;27569044;27597759;27798111;27846572;27920218;28063628;28218747;28228285;28514659;28657654;28832583;28834231;28904123;29242379;29393594;29437277;29557506;29632046;30429286;31217245;31844290;32157095;32192191;32265295;32357974;32387766;32502341;32897882;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33968037;33981976;34087483;34171305;34509645;34606908;34932366;35051231;35580925;36010968;36241641;37938771;38282862;38890444;39406892;8625414;8991089",
        "class_list": "",
        "function": "A peptide encoded by the circular form of the SHPRH gene induces apoptosis in neuroblastoma cells. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; HLTF and SHPRH are functional homologues of yeast Rad5 that cooperatively mediate PCNA polyubiquitination and maintain genomic stability., [RefSeq, PubMed]; HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV rays and methyl methanesulfonate., [RefSeq, PubMed]; Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response., [RefSeq, PubMed]; KMT2B promotes SHPRH expression to regulate (131)I sensitivity in thyroid carcinoma cells by affecting FYN protein stability., [RefSeq, PubMed]; SHPRH function is an important deterrent to mutagenesis and carcinogenesis in humans, [RefSeq, PubMed]; SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]., [RefSeq]; SHPRH maps to 6q24 and is a possible candidate for the tumor suppressor gene reported from that region., [RefSeq, PubMed]; The Human RAD5 Homologs, HLTF and SHPRH, Have Separate Functions in DNA Damage Tolerance Dependent on The DNA Lesion Type. Publication Status: Online-Only, [RefSeq, PubMed]; We report that a putative tumor suppressor gene, SHPRH, is a human orthologue of yeast RAD5.The yRad5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q149N9;Q5VV79;Q68DS5;Q7Z5J5;Q8IVE8;Q8IWQ9;Q8N1S8;Q8NBR7",
        "ec_number_list": "2.3.2.23;2.3.2.27;3.6.4.-",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0031625 ubiquitin protein ligase binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000786 nucleosome;GO:0005634 nucleus",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0016567 protein ubiquitination;GO:0006334 nucleosome assembly;GO:0000209 protein polyubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 9.8,
        "record_id": "Q149N8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NYJ8-1",
        "uniprot_id": "TAB2_HUMAN",
        "mass": 76494.0,
        "length": 693,
        "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2",
        "gene_name": "TAB2",
        "organism": "Human",
        "refseq_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a",
        "refseq_ac": "NP_001278963",
        "gene_names_uniprotkb": "TAB2; KIAA0733; MAP3K7IP2",
        "gene_names_refseq": "CHTD2; MAP3K7IP2; TAB-2; TAB2",
        "protein_names_uniprotkb": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAB-2; TAK1-binding protein 2; TGF-beta-activated kinase 1-binding protein 2",
        "protein_names_refseq": "TAK1-binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a; mitogen-activated protein kinase kinase kinase 7-interacting protein 2",
        "tax_id": 9606,
        "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); congenital heart disease (Disease Ontology:DOID:1682); ovary epithelial cancer (Disease Ontology:DOID:2152); lung non-small cell carcinoma (Disease Ontology:DOID:3908); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074); congenital heart defects, multiple types, 2 (MONDO:MONDO:0014000)",
        "pathway": " (hsa:23118);  (R-HSA-1251985);  (R-HSA-168638);  (R-HSA-202424);  (R-HSA-2871837);  (R-HSA-445989);  (R-HSA-450302);  (R-HSA-450321);  (R-HSA-5357956);  (R-HSA-5607764);  (R-HSA-9014325);  (R-HSA-9020702);  (R-HSA-937042);  (R-HSA-937072);  (R-HSA-9645460);  (R-HSA-9705671);  (R-HSA-975163)",
        "pathway_count": 17,
        "publication_count": 316,
        "publication_id_list": "10.1101/2023.09.13.557529;10075690;10187770;10224040;10329646;10514433;10698680;10702308;10716940;10723127;10779524;10838074;10854325;10882101;10918611;11053425;11057907;11087742;11090634;11094434;11237011;11262391;11323434;11325957;11358993;11460167;11606584;11679632;11772397;11884229;11960013;12019269;12171911;12242293;12473183;12473184;12496252;12514169;12527755;12538665;12609980;12660731;12692549;12759408;12791687;12791997;12796777;12807903;12860405;12917691;14514672;14625308;14633987;15023535;15105418;15122200;15125833;15145317;15208624;15327770;15371334;15492226;15534001;15541657;15620648;15814722;15837794;15845454;15917247;16056267;16061658;16186825;16252004;16260493;16260783;16282325;16289117;16306937;16341139;16356853;16356855;16356856;16603398;16612002;16831874;16912174;16953224;16978534;17018285;17047224;17072321;17135271;17141195;17158449;17303577;17363905;17428801;17449468;17468049;17496917;17507369;17548359;17562858;17675297;17728323;17878161;17890055;17948050;17997719;18070982;18079694;18180283;1828071;18299187;1833184;18438411;18462684;18653779;18669648;18772140;19047365;19112497;19264966;19359218;19521662;19535145;19596786;19651622;19675569;19903815;19934406;19935683;20005846;20038579;20047764;20068231;20193029;20300203;20385093;20493459;20538596;20685844;21158410;2139180;2147937;21512573;21525931;21966355;22069318;22158122;22265677;22798961;22941947;23186163;23230144;23481700;24074955;24129315;24275569;24308844;24434549;24829397;25412445;25576301;25892735;26389808;26992070;27426733;27445336;27466718;27600516;27701768;27746020;27846572;28228285;28514659;28657654;28832583;28834231;28904123;29237092;29242379;29351928;29371260;2946959;29493099;29557506;30059200;30111836;30315122;30379171;30410026;30455202;30620550;30657688;31154438;31373491;31492838;31844290;31848261;31850239;32157095;32350084;32353859;32357974;32387766;32428392;32488085;32574038;32589897;32726803;32728199;32938616;32953130;32979938;32983136;33024073;33060197;33097660;33110251;33184450;33214551;33298915;33349665;33360543;33372174;33372854;33396605;33440148;33479219;33495715;33514628;33567255;33592498;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33912179;33963333;33968037;33989516;33990585;34019948;34021074;34054808;34084167;34110168;34166398;34239064;34290717;34341353;34375313;34400613;34405274;34439781;34452305;34471099;34502139;34597346;34846842;35051231;35102342;35132862;35138101;35251023;35254053;35289036;35513511;35580925;35643212;35978886;36000780;36010968;36284347;36681779;37051252;37340703;38665916;38838015;39302247;39531497;39534244;40136647;40307207;7479848;7499357;7612269;7628694;8327496;8332913;8533096;8550590;8599092;8601309;8622669;8638164;8837778;8972730;9252186;9346484;9362451;9371760;9430229;9430721;9687533;9744859;9768359;9859996;9865693;9990852;9990853",
        "class_list": "",
        "function": "Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020, PubMed:33184450, PubMed:36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Sacral abnormalities including caudal appendage, skeletal dysplasia, and prenatal cardiomyopathy associated with a pathogenic TAB2 variant in a 3-generation family., [RefSeq, PubMed]; TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 14,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 14,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 14,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 7,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCC4;E1P5A0;O94838;Q6I9W8;Q76N06;Q9UFP7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0043130 ubiquitin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0007507 heart development;GO:0032496 response to lipopolysaccharide;GO:0045860 positive regulation of protein kinase activity;GO:0043123 positive regulation of canonical NF-kappaB signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 33.5,
        "record_id": "Q9NYJ8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43251-1",
        "uniprot_id": "RFOX2_HUMAN",
        "mass": 41374.0,
        "length": 390,
        "protein_name": "RNA binding protein fox-1 homolog 2",
        "gene_name": "RBFOX2",
        "organism": "Human",
        "refseq_name": "RNA binding protein fox-1 homolog 2 isoform 1",
        "refseq_ac": "NP_001026865",
        "gene_names_uniprotkb": "RBFOX2; FOX2; HRNBP2; RBM9; RTA",
        "gene_names_refseq": "FOX2; Fox-2; HNRBP2; HRNBP2; RBFOX2; RBM9; RTA; dJ106I20.3; fxh",
        "protein_names_uniprotkb": "RNA binding protein fox-1 homolog 2; Fox-1 homolog B; Hexaribonucleotide-binding protein 2; RNA-binding motif protein 9; RNA-binding protein 9; Repressor of tamoxifen transcriptional activity",
        "protein_names_refseq": "RNA binding protein fox-1 homolog 2 isoform 1; RNA binding protein, fox-1 homolog 2; RNA-binding motif protein 9; fox-1 homolog B; fox-1 homologue; hexaribonucleotide-binding protein 2; repressor of tamoxifen transcriptional activity",
        "tax_id": 9606,
        "disease": "intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); congenital heart disease (Disease Ontology:DOID:1682); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)",
        "pathway": " (hsa:23543);  (R-HSA-6803529)",
        "pathway_count": 2,
        "publication_count": 65,
        "publication_id_list": "10938105;10982855;11237011;11875103;12393912;15601847;16260614;16410617;16449636;16603716;17959601;18477386;18573884;1906035;19285943;22028470;24129315;25576301;25645385;26992070;27600516;28649982;29242379;29331515;29393594;29493099;29557506;29786170;30484775;30779550;30833945;31154438;31217245;31222486;31844290;31848261;32157095;32387766;32897882;32938616;33214551;33392160;33592498;33912179;33968037;33981976;34019948;34171305;34509645;35051231;35318648;35580925;36010968;36241641;36284347;36949200;37264873;37548402;37822160;37938771;38114498;38665916;39531497;9271388;9858549",
        "class_list": "",
        "function": "FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing., [RefSeq, PubMed]; Fox-1 and Fox-2 isoforms specifically activate splicing of neuronally regulated exons, which requires UGCAUG enhancer elements, [RefSeq, PubMed]; RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in gastric cancer., [RefSeq, PubMed]; RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing. Publication Status: Online-Only, [RefSeq, PubMed]; RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer., [RefSeq, PubMed]; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. Together with RNA binding proteins RBPMS and MBNL1/2, activates vascular smooth muscle cells alternative splicing events (PubMed:37548402)., [UniProtKB, PubMed, PubMed]; RNA-binding protein that regulates alternative splicing events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4F5G8;A8K5Z5;B0QYY8;B0QYY9;Q0PRL5;Q0VH35;Q5TF71;Q6IC09;Q8TD00;Q8WYB1;Q96DZ6;Q96NL7;Q9UGW4;Q9UH33",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003714 transcription corepressor activity;GO:0140297 DNA-binding transcription factor binding;GO:0003727 single-stranded RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0007399 nervous system development;GO:0042127 regulation of cell population proliferation;GO:0045892 negative regulation of DNA-templated transcription;GO:0008380 RNA splicing",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "O43251-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NYF8-1",
        "uniprot_id": "BCLF1_HUMAN",
        "mass": 106122.0,
        "length": 920,
        "protein_name": "Bcl-2-associated transcription factor 1",
        "gene_name": "BCLAF1",
        "organism": "Human",
        "refseq_name": "bcl-2-associated transcription factor 1 isoform 2",
        "refseq_ac": "NP_001070908",
        "gene_names_uniprotkb": "BCLAF1; BTF; KIAA0164",
        "gene_names_refseq": "BCLAF1; BTF; bK211L9.1",
        "protein_names_uniprotkb": "Bcl-2-associated transcription factor 1; BCLAF1 and THRAP3 family member 1; Btf",
        "protein_names_refseq": "BCLAF1 and THRAP3 family member 1; bcl-2-associated transcription factor 1 isoform 2; bcl-2-associated transcription factor 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9774)",
        "pathway_count": 1,
        "publication_count": 162,
        "publication_id_list": "10.1101/2023.09.13.557529;10330179;11237011;15009215;15659558;16055720;16083285;16565220;16964243;17081983;17287340;17322306;17487921;17924679;18212344;18318008;18452278;18491316;18669648;18691976;18707149;18767875;18794151;19007248;19367720;19413330;19415658;19562805;19608861;19651622;19664994;19664995;19690332;19691289;20058876;20068230;20068231;20166139;20230923;21406692;21740066;22645359;22833098;22869377;23186163;23301498;23783831;24029068;24100041;24129315;24275569;24397554;24616531;24714562;24715725;25114211;25218447;25418920;25576301;25645385;25755297;25772364;25810538;25880248;25892735;26154972;26375851;26728094;26768311;26811146;26992070;27600516;27846572;27862975;27869121;27920218;28063628;28218747;28228285;28446606;28510447;28514659;28649982;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30379171;30410026;30429286;30444036;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;32157095;32161166;32265295;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33091337;33123756;33141586;33214551;33298915;33465208;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34229054;34372878;34509645;34561969;34932366;35051231;35251023;35254053;35318648;35561310;35580925;36010968;36241641;36284347;37938771;38198022;38340178;38636894;38665916;38805063;39366174;40596516;40914422",
        "class_list": "",
        "function": "BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; BCLAF1 drives esophageal squamous cell carcinoma progression through regulation of YTHDF2-dependent SIX1 mRNA degradation., [RefSeq, PubMed]; BCLAF1 is Expressed as a Potential Anti-oncogene in Bile Duct Cancer., [RefSeq, PubMed]; CircZFR promotes colorectal cancer progression via stabilizing BCLAF1 and regulating the miR-3127-5p/RTKN2 axis., [RefSeq, PubMed]; Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA., [UniProtKB, PubMed]; MED23 depletion induces premature senescence in NSCLC cells by interacting with BCLAF1 and then suppressing NUPR1 expression., [RefSeq, PubMed]; These results suggest that Btf localization is regulated by apoptotic signals, and that loss of emerin binding to Btf may be relevant to muscle wasting in Emery-Dreifuss muscular dystrophy., [RefSeq, PubMed]; This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 10,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 10,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 10,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 93,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 72,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RU75;B7ZM58;E1P586;Q14673;Q86WU6;Q86WY0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003712 transcription coregulator activity;GO:0003729 mRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0016592 mediator complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048255 mRNA stabilization;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 17.6,
        "record_id": "Q9NYF8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P17482-1",
        "uniprot_id": "HXB9_HUMAN",
        "mass": 28059.0,
        "length": 250,
        "protein_name": "Homeobox protein Hox-B9",
        "gene_name": "HOXB9",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-B9",
        "refseq_ac": "NP_076922",
        "gene_names_uniprotkb": "HOXB9; HOX2E",
        "gene_names_refseq": "HOX-2.5; HOX2E; HOX2; HOXB9",
        "protein_names_uniprotkb": "Homeobox protein Hox-B9; Homeobox protein Hox-2.5; Homeobox protein Hox-2E",
        "protein_names_refseq": "homeo box 2E; homeo box B9; homeobox protein Hox-2.5; homeobox protein Hox-2E; homeobox protein Hox-B9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3219)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11857506;23186163;25645385;2570724;2576652;26992070;27600516;28218747;28834231;28904123;29437277;30410026;33912179;35051231;37205792;37258980;38621423;38632141;39390614",
        "class_list": "",
        "function": "Activation of CTHRC1 by HOXB9 Promotes Angiogenesis through Fatty Acid Metabolism in Lung Adenocarcinoma., [RefSeq, PubMed]; HOXB9 promotes laryngeal squamous cell carcinoma progression by upregulating MMP12. Publication Status: Online-Only, [RefSeq, PubMed]; HOXB9 promotes osteosarcoma cell survival and malignancy under glucose starvation via upregulating SPP1 expression., [RefSeq, PubMed]; Homeobox B9 Promotes Colon Cancer Progression by Targeting SRSF3., [RefSeq, PubMed]; Homeobox B9 promotes the invasion and metastasis of hepatocellular carcinoma cells via the EZH2-MIR203A-SNAI2 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]; This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDB7;Q9H1I1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0009954 proximal/distal pattern formation;GO:0060326 cell chemotaxis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "P17482-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75925-1",
        "uniprot_id": "PIAS1_HUMAN",
        "mass": 71836.0,
        "length": 651,
        "protein_name": "E3 SUMO-protein ligase PIAS1",
        "gene_name": "PIAS1",
        "organism": "Human",
        "refseq_name": "E3 SUMO-protein ligase PIAS1 isoform 1",
        "refseq_ac": "NP_001307616",
        "gene_names_uniprotkb": "PIAS1; DDXBP1",
        "gene_names_refseq": "DDXBP1; GBP; GU/RH-II; PIAS1; ZMIZ3",
        "protein_names_uniprotkb": "E3 SUMO-protein ligase PIAS1; 2.3.2.-; DEAD/H box-binding protein 1; E3 SUMO-protein transferase PIAS1; GBP; Gu-binding protein; Protein inhibitor of activated STAT protein 1; RNA helicase II-binding protein",
        "protein_names_refseq": "AR interacting protein; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO-protein ligase PIAS1 isoform 1; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein transferase PIAS1; RNA helicase II-binding protein; gu-binding protein; protein inhibitor of activated STAT protein 1; zinc finger, MIZ-type containing 3",
        "tax_id": 9606,
        "disease": "glutathione synthetase deficiency (Disease Ontology:DOID:0080699); glutatione synthetase deficiency with 5-oxoprolinuria (Disease Ontology:DOID:0081034); congenital nonspherocytic hemolytic anemia 6 (Disease Ontology:DOID:0112252); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); hematologic cancer (Disease Ontology:DOID:2531)",
        "pathway": " (hsa:8554);  (R-HSA-3108214);  (R-HSA-3232118);  (R-HSA-3232142);  (R-HSA-3899300);  (R-HSA-4090294);  (R-HSA-4551638);  (R-HSA-5696395);  (R-HSA-877312)",
        "pathway_count": 9,
        "publication_count": 293,
        "publication_id_list": "10.1101/2023.09.13.557529;10064597;10421843;10526214;10574707;10628744;10734143;10805787;11007478;11121022;11141066;11237011;11278856;11439351;11477070;11511374;11583632;11672422;11792325;11842083;11867732;11889051;11960997;12032081;12072434;12077349;12080057;12144530;12150977;12177000;12223491;12356736;12393906;12419227;12529333;12679040;12718889;12855578;14500712;14500761;14517266;14578449;14701874;15133049;15175327;15192080;15192092;15199155;15208321;15220921;15247228;15280358;15355988;15494207;15507434;15590680;15592428;15608651;15766567;15823533;15829507;15923626;15940266;15958389;15959518;15961505;15976810;16030353;16098147;16478998;16491090;16600910;16608850;16617055;16626738;16688858;16757475;16781829;16810316;16912044;17000769;17018294;17020914;17079232;17081983;17081986;17105732;17218271;17283066;17298944;17314004;17369852;17466625;17466626;17535915;17540171;17693435;17717077;17803295;17942393;17948053;18031232;18082607;18211901;18339323;18374648;18408014;18452278;18488044;18614043;18617891;18625722;18628979;18669648;18691969;18708356;18767875;19041634;19056823;19136629;19211567;19217413;19240082;19287951;19557165;19596686;19615980;19622798;19651622;19661379;19690332;19692572;19706679;19713942;19744555;19779455;19850744;19864602;19906316;19940136;19941824;19955185;19956565;19995069;20016594;20016603;20068231;20098713;20159957;20176810;20190268;20209145;20300531;20351170;20368362;20417598;20547755;20676127;20705237;20719936;20876134;20972456;21098080;21147198;21284855;21338522;21375726;21467194;21527249;21550342;21676946;21724836;21900752;21965678;22022399;22081108;22402492;22467880;22493095;22508508;22539995;22635276;22661230;22713328;22751501;22930759;23038248;23045548;23186163;23202365;23352696;23404503;23417673;23481700;23546875;23673342;23750026;23751493;23871147;24002598;24027577;24068740;24275569;24369422;24390485;24397554;24586797;24714562;24715725;24782567;24835590;24894488;25114211;25154395;25218447;25391492;25418920;25538220;25576301;25704882;25755297;25772364;25800734;25880248;25892735;26042670;26073453;26151477;26154972;26375851;26728094;26811146;26992070;27068747;27211601;27256105;27935866;28842558;28904123;29262325;29437277;29493099;29557506;30379171;30410026;30429286;31217245;31741759;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33592498;33717175;33912179;33936100;33968037;34019948;34087483;34185709;34932366;35051231;35318648;35561310;35580925;36050397;36215666;36284347;37664931;38102979;38190100;38665916;38802795;39534244;7559382;7700386;8692841;9130708;9177271;9412458;9452416;9699634;9716411;9724754;9756909;9771713;9885291",
        "class_list": "",
        "function": "(Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325)., [UniProtKB, PubMed]; CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:15280358, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2, PML and ZNF76 (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:15280358, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation., [RefSeq, PubMed]; PIAS1 is a SUMO ligase for GATA4 that differentially regulates GATA4 transcriptional activity independent of SUMO ligase activity and GATA4 sumoylation., [RefSeq, PubMed]; SUMOylation and coupling of eNOS mediated by PIAS1 contribute to maintenance of vascular homeostasis., [RefSeq, PubMed]; SUMOylation of SMAD4 by PIAS1 in Conjunction with Vimentin Upregulation Promotes Migration Potential in Non-Small Cell Lung Cancer., [RefSeq, PubMed]; This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 19,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 7,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RB67;B3KSY9;C5J4B4;Q147X4;Q99751;Q9UN02",
        "ec_number_list": "2.3.2.-;2.4.2.-;2.4.2.30;2.3.2.27;3.6.4.13;5.6.2.3;5.6.2.4;1.14.11.-;2.3.2.32;3.6.4.-",
        "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005856 cytoskeleton;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 29.8,
        "record_id": "O75925-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NP91-1",
        "uniprot_id": "S6A20_HUMAN",
        "mass": 65914.0,
        "length": 592,
        "protein_name": "Sodium- and chloride-dependent transporter XTRP3",
        "gene_name": "SLC6A20",
        "organism": "Human",
        "refseq_name": "sodium- and chloride-dependent transporter XTRP3 isoform 1",
        "refseq_ac": "NP_064593",
        "gene_names_uniprotkb": "SLC6A20; SIT1; XT3; XTRP3",
        "gene_names_refseq": "IMINO; SIT1; SLC6A20; XT3; Xtrp3",
        "protein_names_uniprotkb": "Sodium- and chloride-dependent transporter XTRP3; Sodium/imino-acid transporter 1; Solute carrier family 6 member 20; Transporter rB21A homolog",
        "protein_names_refseq": "X transporter protein 3; neurotransmitter transporter RB21A; orphan transporter XT3; sodium- and chloride-dependent transporter XTRP3 isoform 1; sodium- and chloride-dependent transporter XTRP3; sodium-dependent imino acid transporter 1; sodium/imino-acid transporter 1; solute carrier family 6 (neurotransmitter transporter), member 20; solute carrier family 6 (proline IMINO transporter), member 20; transporter rB21A homolog",
        "tax_id": 9606,
        "disease": "iminoglycinuria (Disease Ontology:DOID:0112265); hyperglycinuria (MONDO:MONDO:0007677)",
        "pathway": " (hsa:54716);  (R-HSA-352230);  (R-HSA-442660);  (R-HSA-5619101);  (R-HSA-5660686)",
        "pathway_count": 5,
        "publication_count": 71,
        "publication_id_list": "10358010;10391915;10446133;10485994;10684912;10698697;10823827;10863037;10889531;10891391;10903140;10930503;10973981;11237011;11243884;11278508;11318953;11342143;11352561;11417227;11591158;11698620;11827462;11897791;12115694;12151341;12202949;12527723;12809675;12930836;15151999;15286787;15286788;15592994;15632147;15659399;15918515;16226721;16751771;17502375;17726476;18195088;18599538;19033659;2008212;21097500;2387399;24652292;30429286;31848261;33428810;33619245;34425859;34969185;35051231;3571270;7589472;7651355;7874447;8010975;8101838;8125921;8183239;8340364;8632143;8702519;8910405;9174363;9845349;9878049;9932288",
        "class_list": "",
        "function": "Characterization and substrate specificity of the Na+ coupled IMINO transport system in apical brush border membranes of epithelial cells. Identically found in kidney proximal tubule., [RefSeq, PubMed]; Genome and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21.31 locus associated with severe COVID-19. Publication Status: Online-Only, [RefSeq, PubMed]; Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids (PubMed:15632147, PubMed:19033659, PubMed:33428810). Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents (PubMed:33428810)., [UniProtKB, PubMed, PubMed, PubMed]; SIT1 transporter as a potential novel target in treatment of COVID-19. Publication Status: Online-Only, [RefSeq, PubMed]; Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene belongs to the sodium:neurotransmitter symporter (SNF) family and functions as a proline transporter expressed in kidney and small intestine. Mutations in this gene are associated with Hyperglycinuria and Iminoglycinuria. [provided by RefSeq, Jul 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A4F2;O75590;Q8TF10;Q9NPQ2;Q9NQ77",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015193 L-proline transmembrane transporter activity;GO:0015188 L-isoleucine transmembrane transporter activity;GO:0015199 amino-acid betaine transmembrane transporter activity;GO:0005298 proline:sodium symporter activity;GO:0015370 solute:sodium symporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0015816 glycine transport;GO:1903806 L-isoleucine import across plasma membrane;GO:1905647 proline import across plasma membrane;GO:0015824 proline transport;GO:1904271 L-proline import across plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q9NP91-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "W5XKT8-1",
        "uniprot_id": "SACA6_HUMAN",
        "mass": 36333.0,
        "length": 324,
        "protein_name": "Sperm acrosome membrane-associated protein 6",
        "gene_name": "SPACA6",
        "organism": "Human",
        "refseq_name": "sperm acrosome membrane-associated protein 6 isoform 1 precursor",
        "refseq_ac": "NP_001303901",
        "gene_names_uniprotkb": "SPACA6; PRO5774; SPACA6P",
        "gene_names_refseq": "LET7EH; LINC00085; NCRNA00085; SPACA6P; SPACA6",
        "protein_names_uniprotkb": "Sperm acrosome membrane-associated protein 6; BACHELOR-like protein",
        "protein_names_refseq": "BACHELOR-like protein; Let-7e host; long intergenic non-protein coding RNA 85; sperm acrosome associated 6, pseudogene; sperm acrosome membrane-associated protein 6 isoform 1 precursor; sperm acrosome membrane-associated protein 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:147650)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;12975309;24275887;32210282;35051231;35580925;36115925",
        "class_list": "",
        "function": "SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins. Publication Status: Online-Only, [RefSeq, PubMed]; Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion. Publication Status: Online-Only, [RefSeq, PubMed]; Sperm protein required for fusion of sperm with the egg membrane during fertilization (By similarity). May regulate the expression of sperm surface protein DCST2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C0H5Y6;Q6UWG3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0002080 acrosomal membrane",
        "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "W5XKT8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y6W5-1",
        "uniprot_id": "WASF2_HUMAN",
        "mass": 54284.0,
        "length": 498,
        "protein_name": "Actin-binding protein WASF2",
        "gene_name": "WASF2",
        "organism": "Human",
        "refseq_name": "actin-binding protein WASF2 isoform 2",
        "refseq_ac": "NP_001188333",
        "gene_names_uniprotkb": "WASF2; WAVE2",
        "gene_names_refseq": "IMD2; SCAR2; WASF2; WASF4; WAVE2; dJ393P12.2",
        "protein_names_uniprotkb": "Actin-binding protein WASF2; Protein WAVE-2; Verprolin homology domain-containing protein 2; WASP family protein member 2; Wiskott-Aldrich syndrome protein family member 2",
        "protein_names_refseq": "WAS protein family member 2; WASP family Verprolin-homologous protein 2; WASP family protein member 2; WASP family protein member 4; actin-binding protein WASF2 isoform 2; actin-binding protein WASF2; protein WAVE-2; putative Wiskott-Aldrich syndrome protein family member 4; suppressor of cyclic-AMP receptor (WASP-family); verprolin homology domain-containing protein 2; wiskott-Aldrich syndrome protein family member 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10163);  (R-HSA-2029482);  (R-HSA-4420097);  (R-HSA-5663213);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013423);  (R-HSA-9664422)",
        "pathway_count": 8,
        "publication_count": 416,
        "publication_id_list": "10037737;10075701;10207622;10219243;10232922;10381382;10395673;10464238;10490598;10496324;10508610;10523665;10523675;10526156;10559246;10559936;10579713;10618392;10677529;10692392;10699171;10699464;10724160;10744763;10749680;10781580;10847683;10873802;10878810;10958683;10995437;11007481;11058585;11085924;11130076;11145705;11149925;11157975;11231582;11276226;11278486;11329366;11340081;11373293;11396949;11431473;11432776;11553796;11584276;11672528;11695992;11696015;11704860;11707441;11747816;11756552;11773441;11803464;11804587;11804589;11804590;11829459;11854399;11884391;11912491;11919634;11956649;11961559;12055636;12071859;12093360;12096337;12105426;12134158;12189515;12195014;12213210;12214271;12215529;12221096;12235133;12351724;12391143;12432077;12464388;12531887;12546821;12547822;12650940;12660731;12665586;12743368;12810700;12820653;12857875;12877655;12923183;1314888;14512443;14514689;1464587;14675773;14676198;14718541;14724572;15023524;15026417;15033976;15040784;15064355;15070726;15107133;15133129;15147912;15169870;15247219;15302923;15308668;15339924;15342493;15452139;15485661;15507211;15542837;15579468;15601624;15611138;15657136;15688067;15695828;15728722;15814684;15850391;15858067;15897194;15962004;16002401;16081809;16112081;16116428;16184169;16243035;16243036;16262445;16275905;16336962;16417406;16473593;16492808;16507994;16519628;16546099;1660188;16636067;16641196;16702231;16760434;16762923;16777452;16777849;16862148;16880808;16896804;16899465;16914516;16966330;16968698;17030947;17060455;17077126;17081983;17145773;17158234;17188549;17196961;17199126;17202194;17214551;17237347;17244649;17269730;17293873;17308335;17583407;17599059;17686471;17698854;17702745;17765681;17804252;17976533;18006505;18045877;18056264;18070890;18191593;18218625;18249095;18347018;18391171;18396277;18426980;18653540;18662984;18697831;18701695;18838382;19012317;19230644;19267251;19269969;19494238;19534724;19605563;19651622;19673492;19713215;19741094;19798448;19934221;19955216;20068231;20400958;20460433;20658524;20679435;20810653;21037092;21107423;21148482;21151158;21378159;21419341;21445309;21542010;21565175;21613211;21730051;21865595;21989057;22004470;22096251;22298643;22327215;22407364;22475431;22608513;22689825;22734669;22970203;23186163;23209303;23216836;23255595;23288169;23301498;23434736;23572525;23675550;23707487;23718289;23757206;23870057;23940355;24086303;24259668;24335996;24352656;24623723;24715725;2474607;24859002;24933155;24960694;25024229;25121749;25211221;25428919;25576301;25704760;25721503;25795300;25862245;26016997;26129894;26375851;26529257;26628301;26811146;26887924;26992070;27117132;27145964;27216196;27481945;27555588;27566826;27600516;27713499;27806292;27862975;28114311;28196833;28228285;28332566;28356423;28514659;28649982;28832583;28904123;29089502;29242379;29358323;29382922;29393594;29557506;29632046;29786170;30192525;30250061;30315122;30429286;30484775;30779550;30853411;31154438;31217245;31389670;31530632;31844290;31848261;31871319;32157095;32161166;32203420;32357974;32387766;32488085;32502341;32938616;32983136;33043033;33141586;33298915;33392160;33537174;33592498;33691108;33912179;33968037;33981976;34087483;34171305;34509645;35051231;35251023;35477411;35561310;35580925;36010968;36241641;36284347;36968231;40914422;7479768;7509446;7512369;7559638;7673236;7721814;7753201;7835339;7848918;8021274;8107774;8537347;8543060;8617235;8643598;8645157;8662891;8756646;8769096;8798539;8805223;8809042;8810315;8816443;8939998;8986718;8990121;8994827;9013646;9099726;9113980;9182576;9252344;9305890;9393975;9398617;9438849;9472046;9490638;9497316;9582072;9600938;9659915;9670022;9705280;9792683;9799231;9822598;9843499;9883880;9885284;9988689",
        "class_list": "",
        "function": "Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex., [UniProtKB, PubMed, PubMed]; Hypomethylation-mediated upregulation of the WASF2 promoter region correlates with poor clinical outcomes in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The WAVE2/miR-29/Integrin-beta1 Oncogenic Signaling Axis Promotes Tumor Growth and Metastasis in Triple-negative Breast Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 23,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DZN0;O60794;Q9UDY7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0045296 cadherin binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0051018 protein kinase A binding",
        "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0015629 actin cytoskeleton;GO:0016323 basolateral plasma membrane",
        "go_biological_process": "GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0030036 actin cytoskeleton organization;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0098974 postsynaptic actin cytoskeleton organization;GO:0010592 positive regulation of lamellipodium assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 41.9,
        "record_id": "Q9Y6W5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13075-1",
        "uniprot_id": "BIRC1_HUMAN",
        "mass": 159582.0,
        "length": 1403,
        "protein_name": "Baculoviral IAP repeat-containing protein 1",
        "gene_name": "NAIP",
        "organism": "Human",
        "refseq_name": "baculoviral IAP repeat-containing protein 1 isoform 1",
        "refseq_ac": "NP_001333799",
        "gene_names_uniprotkb": "NAIP; BIRC1",
        "gene_names_refseq": "BIRC1; NAIP; NLRB1; psiNAIP",
        "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 1; Neuronal apoptosis inhibitory protein",
        "protein_names_refseq": "baculoviral IAP repeat-containing protein 1 isoform 1; baculoviral IAP repeat-containing protein 1; neuronal apoptosis inhibitory protein; nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1; psi neuronal apoptosis inhibitory protein",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); brain ischemia (Disease Ontology:DOID:2316)",
        "pathway": " (hsa:4671)",
        "pathway_count": 1,
        "publication_count": 39,
        "publication_id_list": "11237011;11896143;11955612;17222062;18414036;19923725;21371431;21918512;22504023;26992070;27862975;29557506;29786170;30429286;31154438;31217245;32157095;32387766;32983136;33392160;33592498;33846244;33936100;34185709;35051231;35494241;35580925;35678562;36010968;36284347;37267294;37586642;37750622;37938771;39894887;7552146;7813013;8552191;9503025",
        "class_list": "",
        "function": "Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila., [UniProtKB]; Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy., [UniProtKB]; Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers., [RefSeq, PubMed]; Deletions of SMNI gene exon 7 and NAIP gene exon 5 in spinal muscular atrophy patients in selected population., [RefSeq, PubMed]; Multiple, domesticated long terminal repeats (LTRs) of endogenous retroviral elements provide NAIP promoter function in human, mouse, and rat., [RefSeq, PubMed]; Pan-cancer analysis of the intervertebral-disc-degeneration-related innate immunity gene NAIP. Publication Status: Online-Only, [RefSeq, PubMed]; Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells., [RefSeq, PubMed]; Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis., [RefSeq, PubMed]; This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EG72;E9PHD1;O75857;Q13730;Q59GI6;Q8TDZ4;Q99796",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0120283 protein serine/threonine kinase binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane;GO:0072557 IPAF inflammasome complex",
        "go_biological_process": "GO:0046456 icosanoid biosynthetic process;GO:0002221 pattern recognition receptor signaling pathway;GO:0007399 nervous system development;GO:0043066 negative regulation of apoptotic process;GO:0045087 innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q13075-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6NYC8-1",
        "uniprot_id": "PPR18_HUMAN",
        "mass": 67943.0,
        "length": 613,
        "protein_name": "Phostensin",
        "gene_name": "PPP1R18",
        "organism": "Human",
        "refseq_name": "phostensin",
        "refseq_ac": "NP_001128342",
        "gene_names_uniprotkb": "PPP1R18; HKMT1098; KIAA1949",
        "gene_names_refseq": "HKMT1098; KIAA1949; PPP1R18",
        "protein_names_uniprotkb": "Phostensin; Protein phosphatase 1 F-actin cytoskeleton-targeting subunit; Protein phosphatase 1 regulatory subunit 18",
        "protein_names_refseq": "phostensin; protein phosphatase 1 F-actin cytoskeleton targeting subunit",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:170954)",
        "pathway_count": 1,
        "publication_count": 62,
        "publication_id_list": "10.1101/2023.09.13.557529;15221005;17081983;17374523;18212344;18669648;18691976;18707149;19007248;19413330;19622346;19851445;20068231;21406692;23186163;23301498;23481700;24275569;24434620;24715725;25576301;25880248;25892735;28832583;28904123;29158294;29242379;29351928;29557506;29769354;30524438;30833945;31154438;31844290;31848261;31998317;32157095;32357974;32488085;32502341;32800345;32897882;32938616;32983136;33592498;33968037;34561969;34932366;35051231;35083852;35251023;35318648;35494241;35561310;35580925;36215666;36284347;37938771;38665916;40307207;40596516;40914422",
        "class_list": "",
        "function": "Authors identified an actin-regulatory protein, protein phosphatase 1 regulatory subunit 18 (PPP1r18), as an Src-binding protein in an Src-, Yes-, and Fyn-deficient fibroblast (SYF) cell line overexpressing a constitutively active form of Src. PPP1r18 was localized in the nucleus and actin ring. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of phostensin in association with Eps 15 homology domain-containing protein 1 (EHD1) and EHD4., [RefSeq, PubMed]; May target protein phosphatase 1 to F-actin cytoskeleton., [UniProtKB, PubMed, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Our data shows that phostensin targets PP1 to F-actin cytoskeleton., [RefSeq, PubMed]; Phostensin is an actin filament pointed end-capping protein that is capable of modulating actin dynamics., [RefSeq, PubMed]; Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 17,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2AB01;A2AIB8;A4UBI6;A6NCB7;A8MSS7;B7ZCV7;Q68CK8;Q6ZTV1;Q6ZUJ6;Q8NDQ4;Q8TF52;Q9BRL9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0019902 phosphatase binding",
        "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q6NYC8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NQT4-1",
        "uniprot_id": "EXOS5_HUMAN",
        "mass": 25249.0,
        "length": 235,
        "protein_name": "Exosome complex component RRP46",
        "gene_name": "EXOSC5",
        "organism": "Human",
        "refseq_name": "exosome complex component RRP46",
        "refseq_ac": "NP_064543",
        "gene_names_uniprotkb": "EXOSC5; CML28; RRP46",
        "gene_names_refseq": "CABAC; EXOSC5; RRP41B; RRP46; Rrp46p; hRrp46p; p12B",
        "protein_names_uniprotkb": "Exosome complex component RRP46; Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12B",
        "protein_names_refseq": "chronic myelogenous leukemia tumor antigen 28; exosome complex component RRP46; exosome complex exonuclease RRP46; exosome component Rrp46; ribosomal RNA-processing protein 46",
        "tax_id": 9606,
        "disease": "cerebellar ataxia, brain abnormalities, and cardiac conduction defects (MONDO:MONDO:0859200)",
        "pathway": " (hsa:56915);  (R-HSA-380994);  (R-HSA-429958);  (R-HSA-450385);  (R-HSA-450513);  (R-HSA-450604);  (R-HSA-6791226);  (R-HSA-9930044)",
        "pathway_count": 8,
        "publication_count": 193,
        "publication_id_list": "10.1101/2023.09.13.557529;10330172;10465791;10958673;11110791;11237011;11283721;11719186;11782436;11812149;11922599;12068309;12150911;12198173;12324455;12359762;12639954;12646273;12705825;12748283;14688255;14742429;14749774;14976220;15014438;15068804;15117938;15175153;15231747;15273322;15385533;15475613;15514971;15538381;15687258;15769464;15944294;16037817;16043514;16141059;16262601;16364914;16648466;16687408;16738141;16912112;16931790;16989641;17030608;17081983;17133347;17174896;17185417;17189298;17245413;17353269;17369404;17412707;17545563;18065403;18285520;18326031;18334637;18367721;18438418;18441014;18481987;18684992;18840095;19060886;19106111;19141871;19198587;19225159;19239894;19332556;19564402;19651622;19729507;19801658;19854161;20022965;20038530;20056613;20068231;20361218;20531386;20531389;20660080;20798176;20805244;20819938;21036871;21063389;21097556;21255825;21515746;21705430;21855801;22072790;22190735;22195017;22645359;22802018;22819556;22916032;22978410;23186163;23223233;23269699;23301498;23439679;23481700;23482395;2388630;24424021;24550520;24714562;24715725;25525153;25578728;25645385;25969445;26024233;26154972;26237581;26375851;2663993;2664463;26992070;27397612;27434818;27543614;27871484;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29298432;29413899;29437277;29508533;29557506;29786170;29789417;29906447;30001391;30315122;30410026;30484775;30950035;31092671;31154438;31217245;31291378;31844290;31937595;31950173;31998317;32157095;32161166;32502341;32504085;3260265;32897882;32938616;33123756;33141586;33298915;33592498;33633747;33691108;33717175;33767452;33912179;33913806;33936100;33968037;34089229;34171305;34211107;35051231;35318648;35561310;35874702;36215666;37875486;40914422;9482744",
        "class_list": "",
        "function": "Association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p, [RefSeq, PubMed]; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (PubMed:11782436, PubMed:21269460). In vitro, EXOSC5 does not bind or digest single-stranded RNA and binds to double-stranded DNA without detectable DNase activity (PubMed:20660080)., [UniProtKB, PubMed, PubMed]; Risk of sudden cardiac death in EXOSC5-related disease., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q32Q81;Q8NG16;Q96I89",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0000175 3'-5'-RNA exonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0006396 RNA processing;GO:0051607 defense response to virus;GO:0006402 mRNA catabolic process;GO:0006364 rRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 19.8,
        "record_id": "Q9NQT4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14530-1",
        "uniprot_id": "TXND9_HUMAN",
        "mass": 26534.0,
        "length": 226,
        "protein_name": "Thioredoxin domain-containing protein 9",
        "gene_name": "TXNDC9",
        "organism": "Human",
        "refseq_name": "thioredoxin domain-containing protein 9",
        "refseq_ac": "NP_005774",
        "gene_names_uniprotkb": "TXNDC9; APACD",
        "gene_names_refseq": "APACD; PHLP3; TXNDC9",
        "protein_names_uniprotkb": "Thioredoxin domain-containing protein 9; ATP-binding protein associated with cell differentiation; Protein 1-4",
        "protein_names_refseq": "ATP binding protein associated with cell differentiation; protein 1-4; thioredoxin domain-containing protein 9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10190)",
        "pathway_count": 1,
        "publication_count": 64,
        "publication_id_list": "10513815;11237011;15104674;16415341;18669648;19054851;19651622;19690332;20068231;20112406;21406692;23186163;24714562;24715725;25418920;25576301;25880248;26154972;26728094;26811146;26992070;27397612;27600516;28510447;28832583;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29786170;29789417;30315122;30429286;30484775;30524438;31154438;31844290;32157095;32265295;32357974;32488085;32502341;32897882;32938616;32983136;33592498;33912179;33936100;33968037;33981976;34019948;34171305;34846159;35051231;35318648;35485284;35580925;36241641;36284347;37303736;40914422",
        "class_list": "",
        "function": "Antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo, [RefSeq, PubMed]; High level of TXNDC9 predicts poor prognosis and contributes to the NF-kappaB-regulated metastatic potential in gastric cancer., [RefSeq, PubMed]; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin., [UniProtKB, PubMed]; TXNDC9 knockdown inhibits lung adenocarcinoma progression by targeting YWHAG., [RefSeq, PubMed]; The protein encoded by this gene is a member of the thioredoxin family. The exact function of this protein is not known but it is associated with cell differentiation. [provided by RefSeq, Jul 2008]., [RefSeq]; Thioredoxin domain-containing protein 9 protects cells against UV-B-provoked apoptosis via NF-kappaB/p65 activation in cutaneous squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9G8;D3DVI4;Q53HG4;Q53RV8;Q6NSF5;Q8TB70;Q9BRU6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030496 midbody",
        "go_biological_process": "GO:0000226 microtubule cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "O14530-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P33151-1",
        "uniprot_id": "CADH5_HUMAN",
        "mass": 87528.0,
        "length": 784,
        "protein_name": "Cadherin-5",
        "gene_name": "CDH5",
        "organism": "Human",
        "refseq_name": "cadherin-5 preproprotein",
        "refseq_ac": "NP_001786",
        "gene_names_uniprotkb": "CDH5",
        "gene_names_refseq": "7B4; CD144; CDH5",
        "protein_names_uniprotkb": "Cadherin-5; 7B4 antigen; VE-cadherin; Vascular endothelial cadherin",
        "protein_names_refseq": "7B4 antigen; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); cadherin-5 preproprotein; cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin",
        "tax_id": 9606,
        "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162); coronary artery disease (Disease Ontology:DOID:3393); thyroid gland carcinoma (Disease Ontology:DOID:3963); pulmonary hypertension (Disease Ontology:DOID:6432)",
        "pathway": " (hsa:1003);  (R-HSA-418990);  (R-HSA-5218920);  (R-HSA-9856530)",
        "pathway_count": 4,
        "publication_count": 116,
        "publication_id_list": "10075701;10225955;10376603;10460833;10639123;10649434;10764742;10861224;11237011;11278486;11804587;11853546;11968001;12050160;12176338;12724311;1522121;15304325;15718470;15980433;16027153;16335952;16467305;16780920;16909109;17060906;17785844;17967169;18083107;18566446;18710921;19020623;19117535;19139490;19212436;19354288;19723632;19996314;20047332;20048167;20308428;20332120;2059658;21123455;21183689;21269602;21464949;21660952;21858121;22285407;22303475;22629427;23090970;23169049;23345538;23719902;24136461;24190977;24358106;24590762;24965120;25030698;25156554;25372031;25447529;25645385;25770237;25795300;26598555;26681130;27338829;27344258;27381080;27466317;27566546;27797339;27852896;27862975;28393886;28712573;29391424;29557506;29741879;29789417;30419037;30814488;31154438;31205027;31346222;31844290;31848261;31927409;31973024;32157095;32296767;32938616;32983136;33043033;34499618;35051231;35580925;37074911;37837820;37938771;38015626;39172098;39195920;39232006;7627717;7806582;7876172;8700127;9219219;9620797;9705280;9845526",
        "class_list": "",
        "function": "Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224). Plays a role in coupling actin fibers to cell junctions in endothelial cells, via acting as a cell junctional complex anchor for AMOTL2 and MAGI1 (By similarity). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120). Positively regulates reorientation of actin stress fibers and endothelial cell reorientation in response to cellular mechantransduction (PubMed:25795300). Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120). Associates with CTNND1/p120-catenin to control CADH5 endocytosis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; Fibrinogen Fragment X Mediates Endothelial Barrier Disruption via Suppression of VE-Cadherin., [RefSeq, PubMed]; Notch1 signaling pathway promotes growth and metastasis of gastric cancer via modulating CDH5., [RefSeq, PubMed]; Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion. Publication Status: Online-Only, [RefSeq, PubMed]; TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization. Publication Status: Online-Only, [RefSeq, PubMed]; The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms., [RefSeq, PubMed]; This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 7,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 81,
        "disease_count": 6,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VAI5;Q4VAI6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0005923 bicellular tight junction",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration;GO:0006874 intracellular calcium ion homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 20.7,
        "record_id": "P33151-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00238-1",
        "uniprot_id": "BMR1B_HUMAN",
        "mass": 56930.0,
        "length": 502,
        "protein_name": "Bone morphogenetic protein receptor type-1B",
        "gene_name": "BMPR1B",
        "organism": "Human",
        "refseq_name": "bone morphogenetic protein receptor type-1B isoform b precursor",
        "refseq_ac": "NP_001194",
        "gene_names_uniprotkb": "BMPR1B",
        "gene_names_refseq": "ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2; BMPR1B; CDw293",
        "protein_names_uniprotkb": "Bone morphogenetic protein receptor type-1B; 2.7.11.30; BMP type-1B receptor; BMPR-1B",
        "protein_names_refseq": "BMP type-1B receptor; BMPR-1B; activin receptor-like kinase 6; bone morphogenetic protein receptor type-1B isoform b precursor; bone morphogenetic protein receptor, type IB; serine/threonine receptor kinase",
        "tax_id": 9606,
        "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); acromesomelic dysplasia 3 (Disease Ontology:DOID:0081237); brachydactyly type A2 (Disease Ontology:DOID:0110965); brachydactyly type A1D (Disease Ontology:DOID:0110978); osteochondrodysplasia (Disease Ontology:DOID:2256); asthma (Disease Ontology:DOID:2841); pulmonary hypertension (Disease Ontology:DOID:6432)",
        "pathway": " (hsa:658);  (R-HSA-201451)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10051328;10458166;10587654;10712517;11016919;11121043;11158580;11237011;11278251;11509558;11571290;11714695;11779505;12151385;12519765;12592392;12821673;12857866;14523231;15805157;16672363;16957682;17029022;17068149;17311849;17344846;17356069;19726563;21791611;23481700;23584533;24098149;24129431;25645385;25758993;26105076;29557506;30315122;30429286;30833945;31092671;31844290;31848261;31937595;31998317;32350084;32387766;32764110;33215411;33308444;33486847;35051231;35501253;7644468;7791754;8119126;8653785;8893010;9136927;9178898;9436979",
        "class_list": "",
        "function": "BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; BMPR1B Polymorphisms (rs1434536 and rs1970801) are Associated With Breast Cancer Susceptibility in Northwest Chinese Han Females: A Case-Control Study., [RefSeq, PubMed]; BMPR1B gene in brachydactyly type 2-A family with de novo R486W mutation and a disease phenotype., [RefSeq, PubMed]; CDMP1 promotes type II collagen and aggrecan synthesis of nucleus pulposus cell via the mediation of ALK6., [RefSeq, PubMed]; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction., [UniProtKB, UniProtKB]; This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 7,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R953;B4DSV1;P78366",
        "ec_number_list": "2.7.11.30;2.3.2.26",
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004888 transmembrane signaling receptor activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004675 transmembrane receptor protein serine/threonine kinase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043235 receptor complex;GO:1990712 HFE-transferrin receptor complex",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071363 cellular response to growth factor stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "O00238-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N682-1",
        "uniprot_id": "DRAM1_HUMAN",
        "mass": 26253.0,
        "length": 238,
        "protein_name": "DNA damage-regulated autophagy modulator protein 1",
        "gene_name": "DRAM1",
        "organism": "Human",
        "refseq_name": "DNA damage-regulated autophagy modulator protein 1",
        "refseq_ac": "NP_060840",
        "gene_names_uniprotkb": "DRAM1; DRAM",
        "gene_names_refseq": "DRAM1; DRAM",
        "protein_names_uniprotkb": "DNA damage-regulated autophagy modulator protein 1; Damage-regulated autophagy modulator",
        "protein_names_refseq": "DNA damage-regulated autophagy modulator protein 1; damage-regulated autophagy modulator",
        "tax_id": 9606,
        "disease": "acute myocardial infarction (Disease Ontology:DOID:9408)",
        "pathway": " (hsa:55332)",
        "pathway_count": 1,
        "publication_count": 37,
        "publication_id_list": "11237011;16839881;17102582;17304243;17397945;19556885;25576301;26992070;27846572;27893789;28228285;28904123;29242379;29557506;30315122;30429286;30484775;31844290;32157095;32350084;32387766;32938616;32943616;32983136;33184797;33592498;33717175;33912179;33968037;34087483;34357683;35154160;35299128;35580925;36241641;37443303;38537746",
        "class_list": "",
        "function": "ARHGAP4 promotes leukemogenesis in acute myeloid leukemia by inhibiting DRAM1 signaling., [RefSeq, PubMed]; Collectively therefore, these studies not only report a stress-induced regulator of autophagy but also highlight the relationship of DRAM and autophagy to p53 function and damage-induced programmed cell death., [RefSeq, PubMed]; DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease., [RefSeq, PubMed]; DNA damage-regulated autophagy modulator 1 prevents glioblastoma cells proliferation by regulating lysosomal function and autophagic flux stability., [RefSeq, PubMed]; DRAM is activated by p53 which is required for the ability of p53 to induce autophagy and is also critical for the ability of p53 to induce programmed cell death., [RefSeq, PubMed]; DRAM links autophagy to p53 and programmed cell death. Review article, [RefSeq, PubMed]; DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR. Publication Status: Online-Only, [RefSeq, PubMed]; DRAM1 plays a tumor suppressor role in clear cell renal cell carcinoma through modulating Akt signaling. Erratum:[Acta Histochem. 2025 Jun;127(2):152259. doi: 10.1016/j.acthis.2025.152259. PMID: 40348626], [RefSeq, PubMed]; Identified FLJ11259/DRAM as a p53-inducible member of a novel family of transmembrane proteins. FLJ11259/DRAM may be an important modulator of p53 responses in diverse tumor types., [RefSeq, PubMed]; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy., [UniProtKB, PubMed, PubMed]; This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z4T0;Q7L3E3;Q9NUN1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0010506 regulation of autophagy;GO:0006915 apoptotic process;GO:0006914 autophagy;GO:0090650 cellular response to oxygen-glucose deprivation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "Q8N682-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NDD1-1",
        "uniprot_id": "FSAF1_HUMAN",
        "mass": 32610.0,
        "length": 293,
        "protein_name": "40S small subunit processome assembly factor 1",
        "gene_name": "FSAF1",
        "organism": "Human",
        "refseq_name": "40S small subunit processome assembly factor 1 isoform b",
        "refseq_ac": "NP_001287759",
        "gene_names_uniprotkb": "FSAF1; C1orf131; cPERP-A",
        "gene_names_refseq": "C1orf131; FSAF1",
        "protein_names_uniprotkb": "40S small subunit processome assembly factor 1",
        "protein_names_refseq": "40S small subunit processome assembly factor 1 isoform b; uncharacterized protein C1orf131",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:128061)",
        "pathway_count": 1,
        "publication_count": 52,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;17525332;18669648;19007248;19608861;19664995;19691289;20068231;20112406;20813266;23186163;25418920;25645385;26992070;27862975;28063628;28228285;28832583;28834231;29242379;29351928;29393594;29493099;29508533;29557506;29632046;29786170;30315122;31154438;31844290;31848261;32157095;32161166;32387766;32502341;32897882;33633747;33717175;33912179;34171305;34509645;34516797;34932366;35051231;35289036;35494241;35561310;36284347;37938771;38928092;40596516",
        "class_list": "",
        "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Prevents helicase DHX37 to be recruited before post-A1 state., [UniProtKB, PubMed]; The Nucleolar Protein C1orf131 Is a Novel Gene Involved in the Progression of Lung Adenocarcinoma Cells through the AKT Signalling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TBI0;Q5TBI1;Q6P6B4;Q7Z6H5;Q8N432;Q96NM6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome;GO:0032040 small-subunit processome",
        "go_biological_process": "GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "Q8NDD1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZT62-1",
        "uniprot_id": "BGIN_HUMAN",
        "mass": 73599.0,
        "length": 677,
        "protein_name": "Bargin",
        "gene_name": "BARGIN",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "BARGIN",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Bargin; Chimeric SH3BP1-PDXP protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 26,
        "publication_id_list": "19367720;19690332;21406692;23186163;23223568;24275569;29557506;30779550;31154438;31844290;31848261;31998317;32357974;32387766;32488085;33298915;33592498;33717175;33912179;33936100;33981976;34171305;34185709;36284347;38665916;40914422",
        "class_list": "",
        "function": "GTPase activating protein (GAP) which specifically converts GTP-bound RAC1 and CDC42 in their inactive GDP-bound form. The GAP activity is enhanced by the non-covalent binding of K-29 and K-48 polyubiquitin chains., [UniProtKB, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:1990450 linear polyubiquitin binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0043547 positive regulation of GTPase activity;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0035020 regulation of Rac protein signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q6ZT62-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NWV8-1",
        "uniprot_id": "BABA1_HUMAN",
        "mass": 36560.0,
        "length": 329,
        "protein_name": "BRISC and BRCA1-A complex member 1",
        "gene_name": "BABAM1",
        "organism": "Human",
        "refseq_name": "BRISC and BRCA1-A complex member 1 isoform 1",
        "refseq_ac": "NP_001028721",
        "gene_names_uniprotkb": "BABAM1; C19orf62; HSPC142; MERIT40; NBA1",
        "gene_names_refseq": "BABAM1; C19orf62; HSPC142; MERIT40; NBA1",
        "protein_names_uniprotkb": "BRISC and BRCA1-A complex member 1; Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex",
        "protein_names_refseq": "BRCA1-A complex subunit MERIT40; BRISC and BRCA1-A complex member 1 isoform 1; mediator of RAP80 interactions and targeting subunit of 40 kDa; mediator of Rap80 interactions and targeting 40 kDa; new component of the BRCA1-A complex; new component of the BRCAA1 A complex",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29086);  (R-HSA-5689901);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-69473)",
        "pathway_count": 6,
        "publication_count": 248,
        "publication_id_list": "10.1101/2023.09.13.557529;10383417;10550055;10572166;10724175;10757784;10766245;10802669;10859164;10866324;10959836;10973490;11025670;11080452;11114888;11139606;11230166;11237011;11301010;11376695;11390408;11390642;11493912;11571274;11573085;11604075;11702069;11893489;11927591;11934988;11955432;12023295;12077346;12152085;12186630;12231622;12353037;12364621;12447390;12485996;12509254;12545175;12578958;12607003;12607005;12697768;12773400;12791985;12792649;12832489;12890688;12897153;12947387;14560035;14561766;14576433;15064416;15177042;15189136;15190204;15201865;15279782;15451442;15468306;15574327;15707391;15723659;16061182;16093244;16148040;16150728;16153896;16327781;16360315;16377563;16427009;16439204;16439205;16530042;16600297;16651405;16874298;16885023;16914548;17081983;17290226;17470781;17525332;17525340;17553757;17575048;17707232;17848578;17928296;17965729;18001824;18001825;18006705;18046455;18077395;18171670;18397950;18443292;18452278;18644861;18669648;18691976;18758443;18805091;18923075;18971343;19001859;19092802;19117993;19176521;19202061;19203578;19203579;19214193;19234442;19261746;19261748;19261749;19351884;19357644;19413330;19419957;19505854;19572197;19651622;19664994;19664995;19690332;19782031;20016603;20023648;20068231;20154705;20166139;20233725;20351172;21052091;21240188;21263215;21282113;21293379;21325134;21335604;21406692;21659603;21680713;21777809;22021381;22024395;22179609;22231403;22234877;22373579;22508508;22529269;22589545;22635276;22661229;22661230;22792074;22908299;22977173;22980979;23186163;23246432;23301498;23306437;23333306;23345434;23468639;23481700;23505375;23727112;24075985;24236237;24275569;24667604;24714562;25113031;25122754;25283148;25512557;25558984;25576301;25645385;25659039;25818648;25841101;26154972;26195665;26728094;26992070;27600516;27846572;28218747;28228285;28510447;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632711;29786170;30315122;30379171;30410026;30429286;30484775;31154438;31844290;31848261;31998317;32157095;32161166;32357974;32488085;32897882;32938616;33592498;33912179;33968037;34211107;35051231;35318648;35580925;36010968;36172813;36315652;37248434;40914422;8422676;8944023;9168116;9259561;9430729;9488723;9512523;9705271;9826654",
        "class_list": "",
        "function": "A stable complex containing MERIT40 acts early in DNA damage response and regulates damage-dependent BRCA1 localization., [RefSeq, PubMed]; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985)., [UniProtKB, PubMed, PubMed, PubMed]; Germline mutations in MERIT40 are rare or absent in familial breast cancer patients., [RefSeq, PubMed]; MERIT40 represents a novel factor that links BRCA1-Rap80 complex integrity, DSB recognition, and ubiquitin chain hydrolytic activities to the DNA damage response., [RefSeq, PubMed]; NBA1 is required to maintain BRE and Abra1 abundance and for the recruitment of BRCA1 to sites of DNA damage. In depth bioinformatics analysis revealed that the BRCA1 A complex bears striking similarities to the 19S proteasome complex., [RefSeq, PubMed]; Phosphoproteomic Analysis Defines BABAM1 as mTORC2 Downstream Effector Promoting DNA Damage Response in Glioblastoma Cells., [RefSeq, PubMed]; WWOX binds MERIT40 and modulates its function in homologous recombination, implications in breast cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MQT0;B4DRY9;B4DVR1;Q6FIA0;Q9P018",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070552 BRISC complex",
        "go_biological_process": "GO:0051301 cell division;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair;GO:0007095 mitotic G2 DNA damage checkpoint signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 25.5,
        "record_id": "Q9NWV8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P2H0-1",
        "uniprot_id": "CE126_HUMAN",
        "mass": 125916.0,
        "length": 1117,
        "protein_name": "Centrosomal protein of 126 kDa",
        "gene_name": "CEP126",
        "organism": "Human",
        "refseq_name": "centrosomal protein of 126 kDa isoform 1",
        "refseq_ac": "NP_065853",
        "gene_names_uniprotkb": "CEP126; KIAA1377",
        "gene_names_refseq": "CEP126; KIAA1377",
        "protein_names_uniprotkb": "Centrosomal protein of 126 kDa",
        "protein_names_refseq": "centrosomal protein 126kDa; centrosomal protein of 126 kDa isoform 1; centrosomal protein of 126 kDa",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57562)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;19799413;22264561;24867236;28411811;30379171;30779550;30958603;31154438;31848261",
        "class_list": "",
        "function": "CEP126 is a regulator of microtubule organisation at the centrosome that acts through modulation of the transport of pericentriolar satellites, and consequently, of the organisation of cell structure, [RefSeq, PubMed]; It was exhibited that KIAA1377 was able to promote the proliferation and motility of both KYSE-150 and HeLa cells, which can be reverted by re-expression of let-7b-5p. The luciferase reporter assay verified that let-7b-5p can diametrically target KIAA1377. Collectively, our data demonstrated that let-7b-5p can directly but negatively regulate KIAA1377 in SCC cell lines, Ecal109, and HeLa cells., [RefSeq, PubMed]; KIAA1377 and C5orf42 gene synergistically play a role as susceptibility genes for monomelic amyotrophy., [RefSeq, PubMed]; Participates in cytokinesis (PubMed:19799413). Necessary for microtubules and mitotic spindle organization (PubMed:24867236). Involved in primary cilium formation (PubMed:24867236)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4G0U6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005813 centrosome;GO:0030496 midbody;GO:0097546 ciliary base",
        "go_biological_process": "GO:0060271 cilium assembly;GO:1905515 non-motile cilium assembly;GO:0007052 mitotic spindle organization;GO:0031122 cytoplasmic microtubule organization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9P2H0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14787-1",
        "uniprot_id": "TNPO2_HUMAN",
        "mass": 101388.0,
        "length": 897,
        "protein_name": "Transportin-2",
        "gene_name": "TNPO2",
        "organism": "Human",
        "refseq_name": "transportin-2 isoform 2",
        "refseq_ac": "NP_001129667",
        "gene_names_uniprotkb": "TNPO2",
        "gene_names_refseq": "IDDHISD; IPO3; KPNB2B; TNPO2; TRN2",
        "protein_names_uniprotkb": "Transportin-2; Karyopherin beta-2b",
        "protein_names_refseq": "importin 3; karyopherin beta 2b, transportin; karyopherin beta-2b; transportin 2 (importin 3, karyopherin beta 2b); transportin-2 isoform 2",
        "tax_id": 9606,
        "disease": "intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies (Disease Ontology:DOID:0081262)",
        "pathway": " (hsa:30000)",
        "pathway_count": 1,
        "publication_count": 74,
        "publication_id_list": "11237011;12384575;14981248;18446792;19608861;22544926;23033978;23301498;24715725;25418920;25576301;25645385;25892735;26154972;26375851;27846572;28218747;28228285;28514659;28832583;28904123;29242379;29314611;29331515;29437277;29493099;29557506;29769354;29786170;29789417;30315122;30429286;31092671;31154438;31217245;31530632;31605449;31844290;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33122699;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;34019948;34087483;34171305;34314705;34357683;34509645;34932366;35051231;35318648;35580925;36010968;36215666;36241641;36284347;37938771;40914422;9298975",
        "class_list": "",
        "function": "Karyopherin beta 2B participates in mRNA export from the nucleus, [RefSeq, PubMed]; Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity)., [UniProtKB]; TNPO2 operates downstream of DYNC1I1 and promotes gastric cancer cell proliferation and inhibits apoptosis., [RefSeq, PubMed]; TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila., [RefSeq, PubMed]; Transportin-2 mediates nuclear import of HuR protein in vitro, [RefSeq, PubMed]; Transportin-2 plays a critical role in nucleocytoplasmic shuttling of oestrogen receptor-alpha. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O14655;Q6IN77",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031267 small GTPase binding;GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031981 nuclear lumen",
        "go_biological_process": "GO:0006606 protein import into nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 7.7,
        "record_id": "O14787-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P50539-1",
        "uniprot_id": "MXI1_HUMAN",
        "mass": 26062.0,
        "length": 228,
        "protein_name": "Max-interacting protein 1",
        "gene_name": "MXI1",
        "organism": "Human",
        "refseq_name": "max-interacting protein 1 isoform c",
        "refseq_ac": "NP_001008541",
        "gene_names_uniprotkb": "MXI1; BHLHC11",
        "gene_names_refseq": "MAD2; MXD2; MXI1; MXI; bHLHc11",
        "protein_names_uniprotkb": "Max-interacting protein 1; Class C basic helix-loop-helix protein 11; Max interactor 1; bHLHc11",
        "protein_names_refseq": "MAX dimerization protein 2; MAX-interacting protein 1; Max-related transcription factor; class C basic helix-loop-helix protein 11; max-interacting protein 1 isoform c",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); breast adenocarcinoma (Disease Ontology:DOID:3458); neurofibrosarcoma (Disease Ontology:DOID:3512); esophageal cancer (Disease Ontology:DOID:5041)",
        "pathway": " (hsa:4601)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;23481700;26154972;28832583;29507620;29557506;29632711;30118760;31154438;31844290;32897882;32901121;33298915;35051231;35254053;35501353;35580925;40596516;7773287;7789959;8425219;8838813;8918230",
        "class_list": "",
        "function": "Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]., [RefSeq]; HIF-1alpha-induced FOXO3a promotes apoptosis of hypoxic endothelial cells by directly inducing Mxi1- 0, which leads to the activation of caspase-8 apoptotic pathway., [RefSeq, PubMed]; Mxi1 participates in the progression of lung cancer via the microRNA-300/KLF9/GADD34 Axis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX., [UniProtKB]; UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1ANN7;D3DR25;D3DRA9;Q15887;Q6FHW2;Q96E53",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "P50539-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P23280-1",
        "uniprot_id": "CAH6_HUMAN",
        "mass": 35367.0,
        "length": 308,
        "protein_name": "Carbonic anhydrase 6",
        "gene_name": "CA6",
        "organism": "Human",
        "refseq_name": "carbonic anhydrase 6 isoform 1 precursor",
        "refseq_ac": "NP_001206",
        "gene_names_uniprotkb": "CA6",
        "gene_names_refseq": "CA-VI; CA6; GUSTIN",
        "protein_names_uniprotkb": "Carbonic anhydrase 6; 4.2.1.1; CA-VI; Carbonate dehydratase VI; Carbonic anhydrase VI; Salivary carbonic anhydrase; Secreted carbonic anhydrase",
        "protein_names_refseq": "carbonate dehydratase VI; carbonic anhydrase 6 isoform 1 precursor; carbonic anhydrase VI; salivary carbonic anhydrase; secreted carbonic anhydrase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:765);  (R-HSA-1475029)",
        "pathway_count": 2,
        "publication_count": 53,
        "publication_id_list": "10409679;11121027;11237011;11676494;120192;14611844;15501038;1554744;16006130;16302824;17228881;17314045;17427958;17499996;17705204;17761422;18162396;18294854;18703501;1899030;19186056;19206230;20349499;20493921;20578724;2111324;21282642;2169869;22001224;234739;29391424;29557506;3080418;32125861;35947329;37011600;38467201;38687739;38732551;39212776;4628675;4994926;6407977;6433979;6819139;7625839;8083199;8356065;8399223;9054574;9336012;9635771;9784398",
        "class_list": "",
        "function": "Association between Carbonic Anhydrase VI Gene Copy Number Variations and Dental Caries Experience., [RefSeq, PubMed]; Association between LTF/MMP20/CA6/TAS1R2 polymorphisms and susceptibility to dental caries. Publication Status: Online-Only, [RefSeq, PubMed]; Association of the bitter taste genes TAS2R38 and CA6 and breast cancer risk; a case-control study of Polish women in Poland and Polish immigrants in USA. Publication Status: Online-Only, [RefSeq, PubMed]; Gene Methylation Affects Salivary Levels of the Taste Buds' Trophic Factor, Gustin Protein. Publication Status: Online-Only, [RefSeq, PubMed]; Reversible hydration of carbon dioxide. Its role in saliva is unknown., [UniProtKB, UniProtKB, UniProtKB]; The gustin gene variation at rs2274333 and PROP taster status affect dietary fat perception: a stepwise multiple regression model study., [RefSeq, PubMed]; The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 2,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 831,
        "biomarker_type": "",
        "glycan_count": 13,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E7EMQ1;Q5FBW3;Q5FC00;Q96QX8;Q9UF03",
        "ec_number_list": "4.2.1.1;4.2.1.69",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "P23280-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UM22-1",
        "uniprot_id": "EPDR1_HUMAN",
        "mass": 25437.0,
        "length": 224,
        "protein_name": "Mammalian ependymin-related protein 1",
        "gene_name": "EPDR1",
        "organism": "Human",
        "refseq_name": "mammalian ependymin-related protein 1 isoform 2 precursor",
        "refseq_ac": "NP_001229875",
        "gene_names_uniprotkb": "EPDR1; MERP1; UCC1",
        "gene_names_refseq": "EPDR1; EPDR; MERP-1; MERP1; UCC1",
        "protein_names_uniprotkb": "Mammalian ependymin-related protein 1; MERP-1; Upregulated in colorectal cancer gene 1 protein",
        "protein_names_refseq": "mammalian ependymin related protein 1; mammalian ependymin-related protein 1 isoform 2 precursor; upregulated in colorectal cancer gene 1 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54749)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "10.1101/2023.09.13.557529;11749721;16954209;19159218;28228285;28657654;30729188;31844290;32265295;32350084;32682838;32935479;33902536;33968037;34019948;34357683;35051231;36241641;38683846;40596516",
        "class_list": "",
        "function": "Binds anionic lipids and gangliosides at acidic pH., [UniProtKB, PubMed]; EPDR1 correlates with immune cell infiltration in hepatocellular carcinoma and can be used as a prognostic biomarker., [RefSeq, PubMed]; EPDR1 is related to stages and metastasize in bladder cancer and can be used as a prognostic biomarker. Publication Status: Online-Only, [RefSeq, PubMed]; Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci for Estimating Angle Closure Disease Severity., [RefSeq, PubMed]; Identification of bone mineral density associated genes with shared genetic architectures across multiple tissues: Functional insights for EPDR1, PKDCC, and SPTBN1. Publication Status: Online-Only, [RefSeq, PubMed]; Shows that the mouse ortholog is a lysosomal protein., [RefSeq, PubMed]; The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4C0;C9JYS3;Q06BL0;Q99M77",
        "ec_number_list": "",
        "go_molecular_function": "GO:1905573 ganglioside GM1 binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome;GO:0043202 lysosomal lumen",
        "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:1990764 myofibroblast contraction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q9UM22-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00478-1",
        "uniprot_id": "BT3A3_HUMAN",
        "mass": 65002.0,
        "length": 584,
        "protein_name": "Butyrophilin subfamily 3 member A3",
        "gene_name": "BTN3A3",
        "organism": "Human",
        "refseq_name": "butyrophilin subfamily 3 member A3 isoform c",
        "refseq_ac": "NP_001229732",
        "gene_names_uniprotkb": "BTN3A3; BTF3",
        "gene_names_refseq": "BTF3; BTN3.3; BTN3A3",
        "protein_names_uniprotkb": "Butyrophilin subfamily 3 member A3",
        "protein_names_refseq": "butyrophilin 3; butyrophilin subfamily 3 member A3 isoform c",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10384);  (R-HSA-8851680)",
        "pathway_count": 2,
        "publication_count": 59,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12502743;15340161;16751379;17785817;19349973;19531472;20208008;20610803;20944003;21918970;22767497;22846996;24036152;24190977;24703779;24714562;25505266;25637025;25657647;25880248;26154972;26811146;27397612;27846572;28832583;29557506;29632711;30315122;30429286;30833945;30858559;31092671;31154438;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33912179;33968037;34185709;34509645;34932366;35051231;35154160;35580925;36010968;36804966;9149941",
        "class_list": "",
        "function": "Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population., [RefSeq, PubMed]; Macrophage-specific silencing of BTN3A3 in breast cancer cells decreased cancer stem cell frequency and tumor growth. Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3 monoclonal antibodies has a therapeutic effect on breast cancer., [RefSeq, PubMed]; Plays a role in T-cell responses in the adaptive immune response., [UniProtKB, PubMed]; The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 9577,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DWI7;E9PCP5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production;GO:0002456 T cell mediated immunity",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "O00478-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N9W6-1",
        "uniprot_id": "BOLL_HUMAN",
        "mass": 31301.0,
        "length": 283,
        "protein_name": "Protein boule-like",
        "gene_name": "BOLL",
        "organism": "Human",
        "refseq_name": "protein boule-like isoform 3",
        "refseq_ac": "NP_001271287",
        "gene_names_uniprotkb": "BOLL; BOULE",
        "gene_names_refseq": "BOLL; BOULE",
        "protein_names_uniprotkb": "Protein boule-like",
        "protein_names_refseq": "bol, boule-like; boule homolog, RNA binding protein; boule-like RNA binding protein; boule-like protein; protein boule-like isoform 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:66037)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;11390979;12499397;15066460;16115862;17114206;19615748;31429579;34653405;37957469",
        "class_list": "",
        "function": "BOULE may encode a key conserved switch that regulates progression of germ cells through meiosis in men., [RefSeq, PubMed]; Direct reprogramming of human Sertoli cells into male germline stem cells with the self-renewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes., [RefSeq, PubMed]; Novel Mutations Reduce Expression of Meiotic Regulators SYCE1 and BOLL in Testis of Azoospermic Men from West Bengal, India., [RefSeq, PubMed]; Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Role in spermatogenesis. Decreased DAZ proteins in spermatogenic failure may be due to germ cell loss. Transcription of BOULE, DAZL, and DAZ not altered in degrees of spermatogenic failure. No increase of DAZL or BOULE found in DAZ deletion., [RefSeq, PubMed]; This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DZA4;Q0JW32;Q53T62;Q969U3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0008494 translation activator activity;GO:0003730 mRNA 3'-UTR binding;GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0051321 meiotic cell cycle;GO:0045948 positive regulation of translational initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q8N9W6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TBZ8-1",
        "uniprot_id": "ZN564_HUMAN",
        "mass": 63735.0,
        "length": 553,
        "protein_name": "Zinc finger protein 564",
        "gene_name": "ZNF564",
        "organism": "Human",
        "refseq_name": "zinc finger protein 564",
        "refseq_ac": "NP_659413",
        "gene_names_uniprotkb": "ZNF564",
        "gene_names_refseq": "ZNF564",
        "protein_names_uniprotkb": "Zinc finger protein 564",
        "protein_names_refseq": "zinc finger protein 564",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:163050);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "10235266;10330177;11237011;11395415;14519192;15175151;15896744;16606702;16719718;18160138;20112406;2163759;25218447;25418920;25469497;25892735;26154972;26811146;26992070;27846572;27920218;28063628;28218747;28514659;28832583;28860189;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29786170;30779550;31154438;31217245;31530632;31844290;32157095;32265295;32357974;32387766;32897882;32983136;33633747;33968037;34414857;35580925;36215666;36284347;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "Long non-coding RNA ZFAS1 alleviates bupivacaine-induced neurotoxicity by regulating the miR-421/zinc finger protein564 (ZNF564) axis., [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EGT4;Q6P1K6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q8TBZ8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P32969-1",
        "uniprot_id": "RL9_HUMAN",
        "mass": 21863.0,
        "length": 192,
        "protein_name": "Large ribosomal subunit protein uL6",
        "gene_name": "RPL9P7; RPL9P8; RPL9P9; RPL9",
        "organism": "Human",
        "refseq_name": "large ribosomal subunit protein uL6",
        "refseq_ac": "NP_000652",
        "gene_names_uniprotkb": "RPL9P7; RPL9P8; RPL9P9; RPL9; SW-cl.103",
        "gene_names_refseq": "L9; NPC-A-16; RPL9; uL6",
        "protein_names_uniprotkb": "Large ribosomal subunit protein uL6; 60S ribosomal protein L9",
        "protein_names_refseq": "60S ribosomal protein L9; large ribosomal subunit protein uL6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6133);  (R-HSA-156827);  (R-HSA-156902);  (R-HSA-1799339);  (R-HSA-192823);  (R-HSA-2408557);  (R-HSA-6791226);  (R-HSA-72689);  (R-HSA-72706);  (R-HSA-72764);  (R-HSA-9010553);  (R-HSA-9633012);  (R-HSA-975956);  (R-HSA-975957);  (R-HSA-9954709);  (R-HSA-9954714);  (R-HSA-9954716)",
        "pathway_count": 17,
        "publication_count": 291,
        "publication_id_list": "10358005;10659855;1095581;10970870;10982836;11018020;11018027;11237011;11265756;11331269;11532962;11544179;11546874;11551508;11677247;11691921;11726970;11922599;11964406;12068309;12150911;12417715;12493757;12554878;12588972;12718880;12832468;12853463;1400365;14527413;14567916;14630918;14636577;14654843;14742663;14973490;15034551;15104674;15317934;15385533;15534230;15546618;15721257;15775988;15781252;15821744;16026328;16037817;16043514;16186820;16209946;16284618;16452507;16469117;16601204;16622410;16630668;16738141;16989641;17053788;17142313;17189298;17267404;17308301;17352659;17353269;17363904;17412707;17726049;17803942;17893241;18065403;18066079;18166647;18230761;18256688;18285520;18423202;18438418;18447580;18447585;18455985;18524595;18539146;1856230;1861871;18657639;18974281;18991276;19060897;19106111;19150429;19332556;19359157;19417104;19478851;19503078;19556969;19564402;19608861;19608919;19706539;19801658;19859661;19909264;20023408;20038530;20056613;2006156;20068231;20305658;20361218;20444697;20479275;20531386;20691628;20798176;20805244;20817927;20819938;20930030;21029861;21036871;21063389;21097556;21145460;21419344;21872626;21993680;22072790;22121020;22190735;22195017;22916032;23085078;23217742;23234702;23269699;23439679;23481700;23482395;23636399;23685075;23746841;2388630;24366607;24424021;24524803;24550520;24714562;24715725;25132172;25242263;25418920;25469497;25505266;25525153;25576301;25578875;25645385;25802875;25810538;25969445;26154972;26237581;26375851;26728094;26758079;26929215;26992070;27452731;27526673;27600516;27846572;27862975;27920218;28063628;28065601;28132843;28218747;28228285;28514659;28685749;28832583;28834231;28904123;29242379;29393594;29413899;29493099;29508533;29557506;29632046;29632312;29632711;29786170;29789417;30192525;30244831;30293783;30315122;30410026;30484775;30524438;30804176;30833945;31011209;31154438;31217245;31222486;31530632;31611695;31844290;31848261;31937595;32099016;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32579943;32669547;32870666;32897882;32938616;32983136;33091337;33141586;33214551;33298915;33392160;33406423;33537174;33592498;33691108;33909987;33912179;33936100;33968037;33981976;34019948;34078123;34171305;34357683;34483448;34509645;34725712;34932366;35051231;35138101;35154160;35318648;35580925;36010968;36215666;36240223;36241641;36284347;36302773;37217939;37676773;37938771;38639179;38665916;39395807;40596516;40914422;429297;592398;592399;641056;6568109;6901506;7990965;8336711;8407925;8415001;8597601;8890909;9211906;9431993;9482744;9582194;9631292;9637248;9712840",
        "class_list": "",
        "function": "Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547)., [UniProtKB, PubMed, PubMed]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis., [RefSeq, PubMed]; RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells., [RefSeq, PubMed]; Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol",
        "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006412 translation;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation",
        "synthesized_glycan_count": 0,
        "hit_score": 29.5,
        "record_id": "P32969-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N126-1",
        "uniprot_id": "CADM3_HUMAN",
        "mass": 43300.0,
        "length": 398,
        "protein_name": "Cell adhesion molecule 3",
        "gene_name": "CADM3",
        "organism": "Human",
        "refseq_name": "cell adhesion molecule 3 isoform 2 precursor",
        "refseq_ac": "NP_001120645",
        "gene_names_uniprotkb": "CADM3; IGSF4B; NECL1; PRO258; SYNCAM3; TSLL1",
        "gene_names_refseq": "BIgR; CADM3; CMT2FF; IGSF4B; NECL1; Necl-1; TSLL1; synCAM3",
        "protein_names_uniprotkb": "Cell adhesion molecule 3; Brain immunoglobulin receptor; IgSF4B; Immunoglobulin superfamily member 4B; NECL-1; Nectin-like protein 1; SynCAM3; Synaptic cell adhesion molecule 3; TSLC1-like protein 1; TSLL1",
        "protein_names_refseq": "TSLC1-like 1; brain immunoglobulin receptor; cell adhesion molecule 3 isoform 2 precursor; immunoglobulin superfamily member 4B; synaptic cell adhesion molecule 3",
        "tax_id": 9606,
        "disease": "Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Charcot-Marie-Tooth disease, axonal, type 2FF (MONDO:MONDO:0030433)",
        "pathway": " (hsa:57863);  (R-HSA-418990);  (R-HSA-420597)",
        "pathway_count": 3,
        "publication_count": 28,
        "publication_id_list": "10225955;11237011;11536053;11544254;12050160;12759359;12975309;15340161;15741237;15893517;16467305;17967169;18420026;19354288;25372031;28411811;29557506;29808799;33592498;33889941;34078123;35051231;37074911;38074074;38515057;7806582;9219219;9845526",
        "class_list": "",
        "function": "A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement. Erratum:[Brain. 2021 Aug 17;144(7):e64. doi: 10.1093/brain/awab181. PMID: 34037698], [RefSeq, PubMed]; CADM3 expression was increased in retinoblastoma tissues and cells. miR-140-5p inhibited CADM3 expression possibly by targeting the 3'-UTR. Publication Status: Online-Only, [RefSeq, PubMed]; Clinical significance of low expression of CADM3 in breast cancer and preliminary exploration of related mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]; Crystallographic analysis of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule, [RefSeq, PubMed]; Involved in cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity)., [UniProtKB, UniProtKB]; Necl-1 is a neural-tissue-specific Ca2+-independent immunoglobulin-like cell-cell adhesion molecule which potentially has membrane-associated guanylate kinase subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites, [RefSeq, PubMed]; The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IZQ9;Q9NVJ5;Q9UJP1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0042734 presynaptic membrane",
        "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q8N126-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P20290-1",
        "uniprot_id": "BTF3_HUMAN",
        "mass": 22168.0,
        "length": 206,
        "protein_name": "Transcription factor BTF3",
        "gene_name": "BTF3",
        "organism": "Human",
        "refseq_name": "transcription factor BTF3 isoform A",
        "refseq_ac": "NP_001032726",
        "gene_names_uniprotkb": "BTF3; NACB; SW-cl.8",
        "gene_names_refseq": "BETA-NAC; BTF3a; BTF3b; BTF3; NACB",
        "protein_names_uniprotkb": "Transcription factor BTF3; NAC-beta; Nascent polypeptide-associated complex subunit beta; RNA polymerase B transcription factor 3",
        "protein_names_refseq": "NAC-beta; RNA polymerase B transcription factor 3; nascent polypeptide-associated complex subunit beta; nascent-polypeptide-associated complex beta polypeptide; transcription factor BTF3 isoform A; transcription factor BTF3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:689);  (R-HSA-9918487)",
        "pathway_count": 2,
        "publication_count": 113,
        "publication_id_list": "10982809;11237011;1386332;17525332;19651622;19664995;20068231;21203952;22706990;22869377;23186163;2320128;23481700;24129315;24275569;24366607;24386364;24715725;25502872;25576301;25645385;25892735;26154972;26375851;26735137;26992070;27543614;27600516;27846572;27862975;27920218;28063628;28228285;28510447;28832583;28834231;28904123;29117567;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30192525;30315122;30484775;30524438;30779550;30833945;31154438;31217245;31222486;31530632;31611695;31717259;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32890404;32897882;32938616;32983136;33141586;33214551;33298915;33537174;33592498;33691108;33717175;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34293363;34357683;34405274;34509645;34561969;34696522;34932366;35051231;35251023;35318648;35580925;35585045;36010968;36215666;36241641;36284347;37217939;37347872;37382415;37938771;38177122;38340226;39278369",
        "class_list": "",
        "function": "BTF3 promotes proliferation and glycolysis in hepatocellular carcinoma by regulating GLUT1., [RefSeq, PubMed]; BTF3-mediated regulation of BMI1 promotes colorectal cancer through influencing epithelial-mesenchymal transition and stem cell-like traits., [RefSeq, PubMed]; In addition to RNA polymerase II (otherwise RNA pol II, RNA polymerase B), four general transcription factors are required for initiation of transcription: BTF1 (also referred to as TFIID) which has recently been cloned from yeast, BTF2, BTF3 and STF., [RefSeq, PubMed]; METTL3-driven m6A modification of lncRNA FAM230B suppresses ferroptosis by modulating miR-27a-5p/BTF3 axis in gastric cancer., [RefSeq, PubMed]; This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]., [RefSeq]; Ubiquitination-specific protease 7 enhances stemness of hepatocellular carcinoma by stabilizing basic transcription factor 3. Publication Status: Online-Only, [RefSeq, PubMed]; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "diagnostic",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K510;Q13893;Q76M56",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005854 nascent polypeptide-associated complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0015031 protein transport;GO:1905551 negative regulation of protein localization to endoplasmic reticulum",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "P20290-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P22748-1",
        "uniprot_id": "CAH4_HUMAN",
        "mass": 35032.0,
        "length": 312,
        "protein_name": "Carbonic anhydrase 4",
        "gene_name": "CA4",
        "organism": "Human",
        "refseq_name": "carbonic anhydrase 4 isoform 1 precursor",
        "refseq_ac": "NP_000708",
        "gene_names_uniprotkb": "CA4",
        "gene_names_refseq": "CA4; CAIV; Car4; RP17",
        "protein_names_uniprotkb": "Carbonic anhydrase 4; 4.2.1.1; CA-IV; Carbonate dehydratase IV; Carbonic anhydrase IV",
        "protein_names_refseq": "CA-IV; carbonate dehydratase IV; carbonic anhydrase 4 isoform 1 precursor; carbonic anhydrase IV; carbonic dehydratase IV",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa 17 (Disease Ontology:DOID:0110404); retinitis pigmentosa (Disease Ontology:DOID:10584)",
        "pathway": " (hsa:762);  (R-HSA-1237044);  (R-HSA-1247673);  (R-HSA-1475029)",
        "pathway_count": 4,
        "publication_count": 107,
        "publication_id_list": "10090333;10409679;10529219;10611283;11121027;11237011;11606574;11676494;120192;12754312;12933803;1311094;1395;14611844;14958;15131110;15501038;1554744;15563508;15858218;16006130;16302824;16563834;16686544;16807956;16992238;16994616;17012249;17127057;17228881;17314045;17427958;17499996;17652713;17705204;17712059;17761422;17990881;18162396;18294854;18618712;18703501;19186056;19206230;19273840;19668749;20068231;20162361;20230836;20349499;20363633;20450258;20493921;20578724;21041929;2111324;21282642;2169869;22001224;234739;23481700;2506737;25937211;27862975;29557506;29786170;29789417;3080418;31154438;3119859;3136125;31848261;31895503;32031891;33141586;34954529;35051231;36944625;3938604;4203704;4514311;4647257;4975618;4994926;5656372;6407977;6417382;6433979;6819139;7541176;7625839;8070313;8083199;8300612;8325641;8356065;8399223;8809084;8875343;8942978;8972395;9054574;9143858;9336012;9486145;9635771;9784398",
        "class_list": "",
        "function": "Carbonic Anhydrase 4 Serves as A Novel Prognostic Biomarker and Therapeutic Target for Non-Small Cell Lung Cancer: A Study Based on TCGA Samples., [RefSeq, PubMed]; Carbonic anhydrase 1 (CA1) and CA4 were identified as potential biomarkers of Colon adenocarcinoma due to their predictive roles in diagnosis and prognosis, and the results were further confirmed by a series of analyses., [RefSeq, PubMed]; Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008]., [RefSeq]; Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH (PubMed:15563508, PubMed:16686544, PubMed:16807956, PubMed:17127057, PubMed:17314045, PubMed:17652713, PubMed:17705204, PubMed:18618712, PubMed:19186056, PubMed:19206230, PubMed:7625839). May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis (PubMed:15563508). It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid (PubMed:15563508)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Enhanced carbonic anhydrase expression with calcification and fibrosis in bronchial cartilage during COPD., [RefSeq, PubMed]; Highest susceptibility effect was noticed in the rs2274328 of carbonic anhydrase VI (AA vs CC) model (d = 0.18; 95% CI (confidence interval): -1.77, 2.13), but this effect was not significant [meta-analysis], [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DQA4;Q6FHI7",
        "ec_number_list": "4.2.1.1;4.2.1.69",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity",
        "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane",
        "go_biological_process": "GO:0015701 bicarbonate transport",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "P22748-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N3L3-1",
        "uniprot_id": "TXLNB_HUMAN",
        "mass": 76519.0,
        "length": 684,
        "protein_name": "Beta-taxilin",
        "gene_name": "TXLNB",
        "organism": "Human",
        "refseq_name": "beta-taxilin",
        "refseq_ac": "NP_694967",
        "gene_names_uniprotkb": "TXLNB; C6orf198; MDP77",
        "gene_names_refseq": "C6orf198; LST001; MDP77; TXLNB; dJ522B19.2",
        "protein_names_uniprotkb": "Beta-taxilin; Muscle-derived protein 77; hMDP77",
        "protein_names_refseq": "beta-taxilin; muscle-derived protein 77",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:167838)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;15082161;15184072;29557506;29632046;31844290;31848261;32157095;32983136;33592498;34932366;35051231;35580925",
        "class_list": "",
        "function": "Identification of isoforms of taxilin; interaction with syntaxin; tissue distribution [beta-taxilin, gamma-taxilin]., [RefSeq, PubMed]; Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5HYH7;Q5VTF3;Q76L25;Q86T52;Q8N3S2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019905 syntaxin binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q8N3L3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PIY7-1",
        "uniprot_id": "GLD2_HUMAN",
        "mass": 56028.0,
        "length": 484,
        "protein_name": "Poly(A) RNA polymerase GLD2",
        "gene_name": "TENT2",
        "organism": "Human",
        "refseq_name": "poly(A) RNA polymerase GLD2 isoform 1",
        "refseq_ac": "NP_001107865",
        "gene_names_uniprotkb": "TENT2; GLD2; PAPD4",
        "gene_names_refseq": "APD4; GLD2; PAPD4; TENT2; TUT2",
        "protein_names_uniprotkb": "Poly(A) RNA polymerase GLD2; 2.7.7.19; PAP-associated domain-containing protein 4; TUTase 2; Terminal nucleotidyltransferase 2; Terminal uridylyltransferase 2; hGLD-2",
        "protein_names_refseq": "PAP associated domain containing 4; PAP-associated domain-containing protein 4; TUTase 2; poly(A) RNA polymerase D4, non-canonical; poly(A) RNA polymerase GLD2 isoform 1; poly(A) RNA polymerase GLD2; terminal uridylyltransferase 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:167153)",
        "pathway_count": 1,
        "publication_count": 68,
        "publication_id_list": "11237011;15070731;15987818;18172165;19690332;20068231;20144904;23186163;23200856;23481700;24715725;25418920;25576301;25645385;25802875;25892735;26375851;26992070;27846572;27920218;28063628;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29769354;29786170;30315122;30410026;30429286;30524438;31057087;31217245;31792053;31844290;32157095;32265295;32357974;32387766;32488085;32502341;32938616;33141586;33298915;33392160;33537174;33592498;33633747;33717175;33756349;33968037;34171305;34185709;34932366;35051231;35318648;35580925;36010968;36071058;37938771;39534244",
        "class_list": "",
        "function": "Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail (PubMed:15070731, PubMed:31792053). In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856, PubMed:31792053)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery., [RefSeq, PubMed]; TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance. Publication Status: Online-Only, [RefSeq, PubMed]; The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3' adenylation and selective stabilization of microRNA-122., [RefSeq, PubMed]; The authors show that the human CPEB1 can repress the activity of the reporter construct containing the HPV-16 early sequences. This repression can be counteracted by a human cytoplasmic poly(A) polymerase, hGLD-2 fused to CPEB1., [RefSeq, PubMed]; The data demonstrate a novel phosphorylation-dependent mechanism to regulate Gld2 activity, revealing tumour suppressor miRNAs(miR-122) as a previously unknown target of Akt1-dependent signalling, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86WZ2;Q8N927",
        "ec_number_list": "2.7.7.19;2.7.7.-;2.7.7.52",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:1990817 poly(A) RNA polymerase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0031380 nuclear RNA-directed RNA polymerase complex",
        "go_biological_process": "GO:0071044 histone mRNA catabolic process;GO:0031124 mRNA 3'-end processing;GO:0031123 RNA 3'-end processing;GO:2000626 negative regulation of miRNA catabolic process;GO:0140958 target-directed miRNA degradation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q6PIY7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P13497-1",
        "uniprot_id": "BMP1_HUMAN",
        "mass": 111249.0,
        "length": 986,
        "protein_name": "Bone morphogenetic protein 1",
        "gene_name": "BMP1",
        "organism": "Human",
        "refseq_name": "bone morphogenetic protein 1 isoform 1 precursor",
        "refseq_ac": "NP_001190",
        "gene_names_uniprotkb": "BMP1; PCOLC",
        "gene_names_refseq": "BMP1; OI13; PCOLC; PCP; TLD",
        "protein_names_uniprotkb": "Bone morphogenetic protein 1; 3.4.24.19; BMP-1; Mammalian tolloid protein; PCP; Procollagen C-proteinase; mTld",
        "protein_names_refseq": "bone morphogenetic protein 1 isoform 1 precursor; mammalian tolloid protein; procollagen C-endopeptidase; procollagen C-proteinase 3; tolloid-like",
        "tax_id": 9606,
        "disease": "osteogenesis imperfecta type 13 (Disease Ontology:DOID:0110342); osteogenesis imperfecta (Disease Ontology:DOID:12347)",
        "pathway": " (hsa:649);  (R-HSA-1474228);  (R-HSA-1650814);  (R-HSA-2214320);  (R-HSA-2243919)",
        "pathway_count": 5,
        "publication_count": 142,
        "publication_id_list": "10.1101/2023.09.13.557529;10229672;10386589;10479448;10706100;10809722;10934207;10986281;11237011;11283002;11313359;11375993;11872628;11986329;12211432;12218058;1237296;12473679;12475640;12637569;12646579;12727852;12843408;1323838;1348714;14500733;14759258;1484505;14973287;15044469;15234972;15591058;1567360;1577494;15958533;16133547;16272566;1649600;16563355;16591531;16631740;16825321;16959974;1698775;1707285;17081983;17332331;17354228;17608959;18434311;18487197;18599485;18658137;18824173;19010778;19075007;19571574;19657146;19693541;19714641;19729652;20142769;20470363;21030783;21297635;21441952;21453682;21670566;21784848;21864727;21878990;21967573;22052668;22159414;22482805;22842973;23035980;23090970;23845380;24190977;25402547;2543975;26944735;28904123;29557506;29741879;3082888;31152061;31611695;3173483;3201241;32157095;32161166;32350084;32357974;32636307;32938616;32983136;33169406;33206546;33592498;34411563;35051231;35251023;35580925;3595596;36010968;36241641;37074911;37657115;37949218;38216590;38860429;3905801;3938630;3992061;41816;5246001;5723342;6129847;6307276;641035;6809411;7075587;710450;7547873;7798260;8226919;8626565;8636146;8643539;9054364;9065415;9115292;9148753;9461298;9470928;9500680;9545296;9560306;9582318;9852107",
        "class_list": "",
        "function": "Activated hepatic stellate cell-derived Bmp-1 induces liver fibrosis via mediating hepatocyte epithelial-mesenchymal transition. Publication Status: Online-Only, [RefSeq, PubMed]; BMP1 Promotes Keloid by Inducing Fibroblast Inflammation and Fibrogenesis., [RefSeq, PubMed]; Bone morphogenetic protein and cancer in spinal fusion: a propensity score-matched analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Characterization of erythroferrone oligomerization and its impact on BMP antagonism., [RefSeq, PubMed]; Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins (PubMed:33206546). Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:32636307, PubMed:33169406). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers (PubMed:31152061, PubMed:33206546). Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (PubMed:32636307)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Plays an important role in bone repair by acting as a coactivator of BMP7., [UniProtKB, PubMed]; This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 5,
        "mined_n_glycosites": 5,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 14,
        "disease_count": 2,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6F5;B2RN46;D3DSR0;Q13292;Q13872;Q14874;Q99421;Q99422;Q99423;Q9UL38",
        "ec_number_list": "3.4.24.-;3.4.24.14;3.4.22.15;3.4.24.24;3.4.24.17;3.4.24.23;3.4.24.19;1.4.3.13;3.4.24.65;1.4.3.-",
        "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0031982 vesicle",
        "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0030154 cell differentiation;GO:0001501 skeletal system development;GO:0030199 collagen fibril organization",
        "synthesized_glycan_count": 0,
        "hit_score": 16.4,
        "record_id": "P13497-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TDC3-1",
        "uniprot_id": "BRSK1_HUMAN",
        "mass": 85087.0,
        "length": 778,
        "protein_name": "Serine/threonine-protein kinase BRSK1",
        "gene_name": "BRSK1",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase BRSK1",
        "refseq_ac": "NP_115806",
        "gene_names_uniprotkb": "BRSK1; KIAA1811; SAD1; SADB",
        "gene_names_refseq": "BRSK1; SAD-B; hSAD1",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase BRSK1; 2.7.11.1; 2.7.11.26; BR serine/threonine-protein kinase 1; Brain-selective kinase 1; Brain-specific serine/threonine-protein kinase 1; SAD1 homolog; Serine/threonine-protein kinase SAD-B; Synapses of Amphids Defective homolog 1; hSAD1",
        "protein_names_refseq": "BR serine/threonine-protein kinase 1; SAD1 homolog; SAD1 kinase; brain-selective kinase 1; brain-specific serine/threonine-protein kinase 1; protein kinase SAD1A; serine/threonine-protein kinase BRSK1; serine/threonine-protein kinase SAD-B; synapses of Amphids Defective homolog 1",
        "tax_id": 9606,
        "disease": "depressive disorder (Disease Ontology:DOID:1596)",
        "pathway": " (hsa:84446)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;14976552;15150265;16630837;17344846;18324781;18339622;19648910;19958286;20026642;21985311;23186163;25576301;27677186;29242379;29485866;29557506;31844290;31895179;32938616;33968037;35051231;37140697",
        "class_list": "",
        "function": "Acts as checkpoint kinase upon DNA damage induced by UV, [RefSeq, PubMed]; BRSK1 confers cisplatin resistance in cervical cancer cells via regulation of mitochondrial respiration., [RefSeq, PubMed]; Protein phosphatase 2C is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2., [RefSeq, PubMed]; Relationship between BRSK1 rs12611091 variant and age at natural menopause based on physical activity., [RefSeq, PubMed]; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; These results suggest that frameshift mutations of EGR1 and BRSK1 might play a role in tumorigenesis through tumor suppressor gene inactivation in colorectal cancer and gastric cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F1DG44;Q5J5B5;Q8NDD0;Q8NDR4;Q8TDC2;Q96AV4;Q96JL4",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0048156 tau protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0014069 postsynaptic density",
        "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0099504 synaptic vesicle cycle;GO:0006468 protein phosphorylation;GO:0007409 axonogenesis;GO:0008306 associative learning",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q8TDC3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P55201-1",
        "uniprot_id": "BRPF1_HUMAN",
        "mass": 137499.0,
        "length": 1214,
        "protein_name": "Peregrin",
        "gene_name": "BRPF1",
        "organism": "Human",
        "refseq_name": "peregrin isoform 1",
        "refseq_ac": "NP_001003694",
        "gene_names_uniprotkb": "BRPF1; BR140",
        "gene_names_refseq": "BR140; BRPF1; IDDDFP",
        "protein_names_uniprotkb": "Peregrin; Bromodomain and PHD finger-containing protein 1; Protein Br140",
        "protein_names_refseq": "bromodomain-containing protein, 140kD; peregrin isoform 1; peregrin",
        "tax_id": 9606,
        "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); intellectual developmental disorder with dysmorphic facies and ptosis (MONDO:MONDO:0015022)",
        "pathway": " (hsa:7862);  (R-HSA-3214847);  (R-HSA-6804758)",
        "pathway_count": 3,
        "publication_count": 60,
        "publication_id_list": "10.1101/2023.09.13.557529;10786633;10821277;11099047;11237011;15302935;15313887;16387653;16839880;17081983;18381289;18452278;18491316;18623064;18669648;18794358;19187765;19608861;19651622;19690332;19691289;20018852;20068231;20228809;20400950;20660729;21406692;21720545;23186163;23431171;24065767;24275569;24715725;25593309;27862975;27939639;27939640;28904123;29242379;29393594;29557506;30429286;31844290;32157095;32387766;32938616;33912179;33968037;34561969;35051231;35580925;37217939;37423512;38346666;38590032;39302247;7906940;9427644;9558366;9880483",
        "class_list": "",
        "function": "Beyond 'speech delay': Expanding the phenotype of BRPF1-related disorder., [RefSeq, PubMed]; Broadening the ocular phenotypic spectrum of ultra-rare BRPF1 variants: report of two cases., [RefSeq, PubMed]; Identified is the PWWP domain of bromo and plant homeodomain (PHD) finger-containing protein 1 (BRPF1) as a histone H3 (H3K36me3) binding module; determined is the structure of this domain in complex with an H3K36me3-derived peptide., [RefSeq, PubMed]; Pygo2 activates BRPF1 via Pygo2-H3K4me2/3 interaction to maintain malignant progression in colon cancer., [RefSeq, PubMed]; Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 17,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DEZ6;Q7Z6E0;Q8TCM6;Q9UHI0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0010698 acetyltransferase activator activity;GO:0140566 histone reader activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000123 histone acetyltransferase complex;GO:0070776 MOZ/MORF histone acetyltransferase complex",
        "go_biological_process": "GO:0050793 regulation of developmental process;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "P55201-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NEK8-1",
        "uniprot_id": "TET5D_HUMAN",
        "mass": 44500.0,
        "length": 389,
        "protein_name": "Terminal nucleotidyltransferase 5D",
        "gene_name": "TENT5D",
        "organism": "Human",
        "refseq_name": "terminal nucleotidyltransferase 5D",
        "refseq_ac": "NP_001164045",
        "gene_names_uniprotkb": "TENT5D; FAM46D",
        "gene_names_refseq": "CT1.26; CT112; FAM46D; TENT5D",
        "protein_names_uniprotkb": "Terminal nucleotidyltransferase 5D; 2.7.7.19; Non-canonical poly(A) polymerase FAM46D",
        "protein_names_refseq": "cancer/testis antigen 112; family with sequence similarity 46 member D; non-canonical poly(A) polymerase FAM46D; protein FAM46D; putative nucleotidyltransferase FAM46D; terminal nucleotidyltransferase 5D",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:169966)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "19540335;23481700;27600516;28832583;28931820;29393594;29557506;29786170;30192525;31844290;31998317;32161166;32433990",
        "class_list": "",
        "function": "Antibodies against the protein encoded by this gene were found only in plasma from cancer patients. While it may be a target for immunotherapy, the function of this gene is unknown. [provided by RefSeq, Dec 2009]., [RefSeq]; Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group., [UniProtKB, PubMed, PubMed]; Overexpression of FAM46D is associated with neoplasms., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9Q6;Q7Z3F6;Q8NHU1",
        "ec_number_list": "2.7.7.19;2.7.7.-;2.7.7.52",
        "go_molecular_function": "GO:1990817 poly(A) RNA polymerase activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0048255 mRNA stabilization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q8NEK8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q71DI3-1",
        "uniprot_id": "H32_HUMAN",
        "mass": 15388.0,
        "length": 136,
        "protein_name": "Histone H3.2",
        "gene_name": "H3C13; H3C14; H3C15",
        "organism": "Human",
        "refseq_name": "histone H3.2",
        "refseq_ac": "NP_001005464",
        "gene_names_uniprotkb": "H3C13; H3C14; H3C15; H3F2; H3FM; HIST2H3A; HIST2H3C; HIST2H3D",
        "gene_names_refseq": "H3/n; H3/o; H3C15; HIST2H3A",
        "protein_names_uniprotkb": "Histone H3.2; H3-clustered histone 13; H3-clustered histone 14; H3-clustered histone 15; Histone H3/m; Histone H3/o",
        "protein_names_refseq": "histone 2, H3a; histone H3.2; histone H3/o; histone cluster 2 H3 family member a; histone cluster 2, H3a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:126961);  (hsa:333932);  (hsa:653604);  (R-HSA-1266695);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-3214815);  (R-HSA-3214841);  (R-HSA-3214842);  (R-HSA-3214847);  (R-HSA-3214858);  (R-HSA-3247509);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-68616);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-983231);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 51,
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        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2BDF6;A6NFS4;Q6B053",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0031507 heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 110.6,
        "record_id": "Q71DI3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UJY1-1",
        "uniprot_id": "HSPB8_HUMAN",
        "mass": 21604.0,
        "length": 196,
        "protein_name": "Heat shock protein beta-8",
        "gene_name": "HSPB8",
        "organism": "Human",
        "refseq_name": "heat shock protein beta-8",
        "refseq_ac": "NP_055180",
        "gene_names_uniprotkb": "HSPB8; CRYAC; E2IG1; HSP22; PP1629",
        "gene_names_refseq": "CMT2L; DHMN2; E2IG1; H11; HMN2A; HMN2; HMND2; HSP22; HSPB8-N1; HSPB8-N2; HSPB8; MFM13",
        "protein_names_uniprotkb": "Heat shock protein beta-8; Alpha-crystallin C chain; E2-induced gene 1 protein; Heat shock protein family B member 8; HspB8; Protein kinase H11; Small stress protein-like protein HSP22",
        "protein_names_refseq": "E2-induced gene 1 protein; alpha-crystallin C chain; heat shock 22kDa protein 8; heat shock 27kDa protein 8; heat shock protein beta-8; heat shock protein family B member 8; protein kinase H11; small stress protein-like protein HSP22",
        "tax_id": 9606,
        "disease": "myofibrillar myopathy 13 with rimmed vacuoles (Disease Ontology:DOID:0051045); adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093); Charcot-Marie-Tooth disease axonal type 2L (Disease Ontology:DOID:0110174); autosomal dominant distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111206)",
        "pathway": " (hsa:26353);  (R-HSA-3371571)",
        "pathway_count": 2,
        "publication_count": 68,
        "publication_id_list": "10833516;11085516;11230166;11237011;11342557;11447121;11470154;11816564;15122253;15270074;15498874;15565283;15760475;16408927;17216044;17344846;18083107;18212344;18220336;18298377;18669648;19464326;20060297;20068231;21526341;22366786;22564745;22721717;22768106;23186163;23796487;25645385;26718575;26992070;27862975;27884606;28144995;28218747;28501893;28832583;28834231;29029362;29331515;29557506;29786170;30379171;30833945;31154438;31403083;31844290;32157095;32165108;32983136;33043033;33592498;33744911;34087483;35051231;35494241;35580925;36010968;36241641;36934244;37437931;38980537;39094362;39548192;8455624",
        "class_list": "",
        "function": "Eukaryotic Elongation Factor 1Alpha-2 (EEF1A2) Participates in the Progression of Gastric Cancer via Interaction with Heat Shock Protein B8 (HSPB8)., [RefSeq, PubMed]; Identification of Alternatively Spliced Novel Isoforms of Human HSPB8 Gene., [RefSeq, PubMed]; Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle. Displays temperature-dependent chaperone activity., [UniProtKB, UniProtKB]; Macrophage-specific autophagy-related gene HSPB8 is involved in the macrophage polarization in atherosclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]., [RefSeq]; The role of heat shock protein B8 in neuronal protection against oxidative stress and mitochondrial dysfunction: A literature review. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6A6;Q6FIH3;Q9UKS3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0101031 protein folding chaperone complex",
        "go_biological_process": "GO:0034620 cellular response to unfolded protein;GO:1905337 positive regulation of aggrephagy",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q9UJY1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y3Y4-1",
        "uniprot_id": "PYGO1_HUMAN",
        "mass": 45116.0,
        "length": 419,
        "protein_name": "Pygopus homolog 1",
        "gene_name": "PYGO1",
        "organism": "Human",
        "refseq_name": "pygopus homolog 1 isoform 2",
        "refseq_ac": "NP_001317255",
        "gene_names_uniprotkb": "PYGO1",
        "gene_names_refseq": "PYGO1",
        "protein_names_uniprotkb": "Pygopus homolog 1",
        "protein_names_refseq": "pygopus homolog 1 isoform 2; pygopus homolog 1; pygopus-like protein 1",
        "tax_id": 9606,
        "disease": "heart conduction disease (Disease Ontology:DOID:10273)",
        "pathway": " (hsa:26108);  (R-HSA-201722);  (R-HSA-3769402)",
        "pathway_count": 3,
        "publication_count": 88,
        "publication_id_list": "10080941;10485845;10549281;10769018;10775268;10831834;10898789;10921920;10944533;11050151;11080158;11136974;11532957;11691915;11713476;11934263;11955446;11973335;11988739;12163411;12408824;12408825;12712206;14600025;14685266;14695187;15060161;15121853;15132997;15294866;15327769;15525529;15768032;15829968;16005293;16169192;16510874;16630820;16756492;17052462;17113272;17218525;17412698;17425782;17428831;17458864;17698607;17875931;18160704;18347063;18378692;18404694;18456656;18498752;18573912;18598779;18819930;19047045;19148484;19364920;19460168;19487454;19493659;19571879;19590513;19928349;19940019;20403915;21654818;21726809;22186018;22190459;22304967;22617422;22982193;24291232;32157095;32938616;36398031;8756721;8757136;8955148;9118222;9488439;9490669;9751710;9819412;9843967",
        "class_list": "",
        "function": "Data show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains from BCL9/Legless to bind specifically to the histone H3 tail methylated at lysine 4 (H3K4me)., [RefSeq, PubMed]; Involved in signal transduction through the Wnt pathway., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer via the Wnt/beta-Catenin Pathway. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
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        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7Y2D6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140002 histone H3K4me3 reader activity",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0001822 kidney development;GO:0060070 canonical Wnt signaling pathway;GO:0007289 spermatid nucleus differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.9,
        "record_id": "Q9Y3Y4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13285-1",
        "uniprot_id": "STF1_HUMAN",
        "mass": 51636.0,
        "length": 461,
        "protein_name": "Steroidogenic factor 1",
        "gene_name": "NR5A1",
        "organism": "Human",
        "refseq_name": "steroidogenic factor 1",
        "refseq_ac": "NP_004950",
        "gene_names_uniprotkb": "NR5A1; AD4BP; FTZF1; SF1",
        "gene_names_refseq": "AD4BP; ELP; FTZ1; FTZF1; NR5A1; POF7; SF-1; SF1; SPGF8; SRXX4; SRXY3; hSF-1",
        "protein_names_uniprotkb": "Steroidogenic factor 1; Adrenal 4-binding protein; Fushi tarazu factor homolog 1; Nuclear receptor subfamily 5 group A member 1; SF-1; STF-1; Steroid hormone receptor Ad4BP; hSF-1",
        "protein_names_refseq": "STF-1; adrenal 4 binding protein; fushi tarazu factor homolog 1; nuclear receptor AdBP4; steroid hormone receptor Ad4BP; steroidogenic factor 1 nuclear receptor; steroidogenic factor 1; steroidogenic factor-1",
        "tax_id": 9606,
        "disease": "spermatogenic failure 8 (Disease Ontology:DOID:0070169); primary ovarian insufficiency 7 (Disease Ontology:DOID:0080864); hypogonadotropic hypogonadism (Disease Ontology:DOID:0090070); 46,XX sex reversal 4 (Disease Ontology:DOID:0111764); 46,XY sex reversal 3 (Disease Ontology:DOID:0111772); gonadal dysgenesis (Disease Ontology:DOID:14447); Zellweger syndrome (Disease Ontology:DOID:905)",
        "pathway": " (hsa:2516);  (R-HSA-383280);  (R-HSA-4090294);  (R-HSA-452723);  (R-HSA-9690406)",
        "pathway_count": 5,
        "publication_count": 137,
        "publication_id_list": "10230405;10235266;10369247;10542397;11038323;11121022;11207191;11237011;11278460;11479297;11865025;11897684;11932325;12077349;12144530;12177000;12787505;14500761;14596681;14688391;15108323;15175151;15192080;15192092;15277698;15342930;15493035;15513931;15582778;15625129;15695770;15707893;15743839;15860457;15889150;15896744;15897460;15923626;15961505;15983365;15988017;16153702;16751179;16912044;16978057;17020914;17068183;17105732;17200175;17204602;17210646;17218271;17267691;17314004;17506876;17567999;17572666;17628018;17664281;17694559;17717077;17901130;18029452;18035408;18212089;18445271;18824471;19015234;19041634;19151334;19211567;19246354;19489980;19522013;19604364;19688839;19692572;19755485;19829295;19850744;19864602;19955185;19966271;20027182;20159957;20505756;20505821;20719936;20837710;20887963;20953172;21412441;21467194;21630377;21924763;22028768;22210884;22215994;22327294;22899867;22930759;22988117;23178592;23546875;23827706;23827708;24405868;25114211;25122490;26523528;27169744;27378692;27490115;27610946;27855412;28459839;28472341;29557506;30425642;30552336;32387766;32870666;33912179;35051231;35592512;36010968;38228887;38555298;39623453;40596516;8806624;8938589;9000051;9177385;9653119;9774680;9815658",
        "class_list": "",
        "function": "A conserved NR5A1-responsive enhancer regulates SRY in testis-determination. Publication Status: Online-Only, [RefSeq, PubMed]; Pituitary neuroendocrine tumors with PIT1/SF1 co-expression show distinct clinicopathological and molecular features. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "total_reported_n_glycosites": 0,
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        "reported_phosphosites": 3,
        "reported_mutagensis": 9,
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        "reported_snv": 6,
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        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15196;Q5T6F5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0007530 sex determination;GO:2000020 positive regulation of male gonad development;GO:0097720 calcineurin-mediated signaling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 14.0,
        "record_id": "Q13285-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43684-1",
        "uniprot_id": "BUB3_HUMAN",
        "mass": 37155.0,
        "length": 328,
        "protein_name": "Mitotic checkpoint protein BUB3",
        "gene_name": "BUB3",
        "organism": "Human",
        "refseq_name": "mitotic checkpoint protein BUB3 isoform b",
        "refseq_ac": "NP_001007794",
        "gene_names_uniprotkb": "BUB3",
        "gene_names_refseq": "BUB3L; BUB3; hBUB3",
        "protein_names_uniprotkb": "Mitotic checkpoint protein BUB3",
        "protein_names_refseq": "BUB3 budding uninhibited by benzimidazoles 3 homolog; budding uninhibited by benomyl; mitotic checkpoint component; mitotic checkpoint protein BUB3 isoform b; mitotic checkpoint protein BUB3; testicular tissue protein Li 27",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:9184);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-174184);  (R-HSA-176409);  (R-HSA-179409);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5663220);  (R-HSA-68877);  (R-HSA-9648025)",
        "pathway_count": 11,
        "publication_count": 184,
        "publication_id_list": "10198256;10411507;10600384;10678165;10679238;10958683;11081627;11181178;11237011;11285280;11371342;11509732;11535616;11742988;11804586;12006501;12194817;12429848;12577064;12679384;12732141;12805219;12852857;14730319;15006353;15085137;15302935;15339662;15507212;15525512;15723797;15737063;15864301;15866170;15944288;15944396;16292343;16439214;16541025;16622419;16622420;16648845;16682347;16890222;16943183;17030981;17112726;17113138;17129783;17196341;17198702;17322306;1737036;18001770;18097444;18199686;18452278;18669648;18716626;18923426;19350017;19608861;19696148;19815554;19965387;20030946;20057499;20068230;20101212;20112406;20591975;21111234;21148482;21397845;21576392;21868368;21878504;21987589;22094460;22275430;22608513;22790947;22885700;23186163;23222643;23301498;23801653;24316223;24397554;24462186;24462187;24715725;24914801;25469497;25502872;25505266;25576301;25740311;25789526;25810538;25880248;26154972;26811146;26992070;27846572;28904123;29371260;29437277;29493099;29557506;30410026;30429286;30484775;30553276;30833945;31154438;31217245;31222486;31409757;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33633747;33691108;33912179;33936100;33968037;33981976;34019948;34171305;34185709;34260926;34357683;34405274;34509645;34561969;34725712;34932366;35008409;35051231;35083852;35085551;35132862;35138101;35156516;35217622;35318648;35493295;35561310;35580925;35705054;36010968;36241641;36284347;37217939;37535603;37938771;38665916;40596516;40914422;9649308;9649503;9660858;9892021",
        "class_list": "",
        "function": "BUBs Are New Biomarkers of Promoting Tumorigenesis and Affecting Prognosis in Breast Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Dual-functional significance of ATM-mediated phosphorylation of spindle assembly checkpoint component Bub3 in mitosis and the DNA damage response., [RefSeq, PubMed]; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; MiR-664b-3p inhibits colon cell carcinoma via negatively regulating Budding uninhibited by benzimidazole 3., [RefSeq, PubMed]; SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3., [RefSeq, PubMed]; This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJ42;B2R6E7;D3DRE9;O43685",
        "ec_number_list": "",
        "go_molecular_function": "GO:0043130 ubiquitin binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000776 kinetochore;GO:0033597 mitotic checkpoint complex;GO:1990298 bub1-bub3 complex",
        "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0051321 meiotic cell cycle;GO:0034501 protein localization to kinetochore",
        "synthesized_glycan_count": 0,
        "hit_score": 18.8,
        "record_id": "O43684-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75973-1",
        "uniprot_id": "C1QRF_HUMAN",
        "mass": 26453.0,
        "length": 258,
        "protein_name": "C1q-related factor",
        "gene_name": "C1QL1",
        "organism": "Human",
        "refseq_name": "C1q-related factor precursor",
        "refseq_ac": "NP_006679",
        "gene_names_uniprotkb": "C1QL1; C1QRF; CRF; CTRP14",
        "gene_names_refseq": "C1QL1; C1QRF; C1QTNF14; CRF; CTRP14",
        "protein_names_uniprotkb": "C1q-related factor; C1q and tumor necrosis factor-related protein 14; C1q/TNF-related protein 14; Complement component 1 Q subcomponent-like 1",
        "protein_names_refseq": "C1q and tumor necrosis factor-related protein 14; C1q-related factor precursor; C1q-related factor; C1q/TNF-related protein 14; complement component 1, q subcomponent-like 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10882)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;19275900;20237496;29321030;29557506;30078552;30429286;30833945;31154438;31844290;32157095;32488085;34171305;35051231;36010968;36241641;38253038;9878755",
        "class_list": "",
        "function": "Conserved recoding RNA editing of vertebrate C1q-related factor C1QL1., [RefSeq, PubMed]; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity)., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; We conclude that the underexpression of CRABP1 and the overexpression of LCN2 may be useful diagnostic biomarkers in thyroid tumours with questionable malignity, and the overexpression of LCN2 and C1QL1 may be useful for prognostic purposes. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0043083 synaptic cleft;GO:0098793 presynapse",
        "go_biological_process": "GO:0007626 locomotory behavior;GO:0099558 maintenance of synapse structure;GO:0099550 trans-synaptic signaling, modulating synaptic transmission;GO:1905806 regulation of synapse pruning",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "O75973-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q00535-1",
        "uniprot_id": "CDK5_HUMAN",
        "mass": 33304.0,
        "length": 292,
        "protein_name": "Cyclin-dependent kinase 5",
        "gene_name": "CDK5",
        "organism": "Human",
        "refseq_name": "cyclin-dependent kinase 5 isoform 2",
        "refseq_ac": "NP_001157882",
        "gene_names_uniprotkb": "CDK5; CDKN5; PSSALRE",
        "gene_names_refseq": "CDK5; LIS7; PSSALRE",
        "protein_names_uniprotkb": "Cyclin-dependent kinase 5; 2.7.11.1; Cell division protein kinase 5; Cyclin-dependent-like kinase 5; Serine/threonine-protein kinase PSSALRE; TPKII catalytic subunit; Tau protein kinase II catalytic subunit",
        "protein_names_refseq": "TPKII catalytic subunit; cell division protein kinase 5; cyclin-dependent kinase 5 isoform 2; cyclin-dependent-like kinase 5; epididymis secretory sperm binding protein; protein kinase CDK5 splicing; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit",
        "tax_id": 9606,
        "disease": "lissencephaly (Disease Ontology:DOID:0050453); lissencephaly 7 with cerebellar hypoplasia (Disease Ontology:DOID:0112231); Alzheimer's disease (Disease Ontology:DOID:10652); trigeminal neuralgia (Disease Ontology:DOID:12098); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); vascular dementia (Disease Ontology:DOID:8725)",
        "pathway": " (hsa:1020);  (R-HSA-180024);  (R-HSA-399956);  (R-HSA-6804756);  (R-HSA-8862803);  (R-HSA-9031628);  (R-HSA-9032845);  (R-HSA-9768919);  (R-HSA-983231);  (R-HSA-9841922);  (R-HSA-9931529);  (R-HSA-9931530)",
        "pathway_count": 12,
        "publication_count": 356,
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        "class_list": "",
        "function": "A loss-of-function of the mutant CDK5 gene product is associated with lissencephaly with cerebellar hypoplasia. Erratum:[Hum Genet. 2015 Mar;134(3):315. doi: 10.1007/s00439-015-1530-0. Katib, Nassser [corrected to Katib, Nasser]; Zur, Shay [corrected to Tzur, Shay]. PMID: 25609191], [RefSeq, PubMed]; CDK5-cyclin B1 regulates mitotic fidelity., [RefSeq, PubMed]; CDK5-splicing variant might also be a negative regulator of Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]; Cdk5 signaling via Rb is critical to medullary thyroid carcinoma tumorigenesis and progression, [RefSeq, PubMed]; MiR-4645-3p attenuates podocyte injury and mitochondrial dysfunction in diabetic kidney disease by targeting Cdk5., [RefSeq, PubMed]; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Negatively regulates the CACNA1B/CAV2.2 -mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in postmitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Also phosphorylates exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators., [RefSeq, PubMed]; This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 9,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1XKG3",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;3.5.1.-;3.5.1.98;2.3.1.48;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;3.1.3.48;1.11.1.24;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.10.1;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;2.3.1.286;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030549 acetylcholine receptor activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007409 axonogenesis;GO:0031175 neuron projection development;GO:0051301 cell division;GO:0051402 neuron apoptotic process;GO:1904646 cellular response to amyloid-beta",
        "synthesized_glycan_count": 0,
        "hit_score": 36.2,
        "record_id": "Q00535-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PKX4-1",
        "uniprot_id": "DOK6_HUMAN",
        "mass": 38318.0,
        "length": 331,
        "protein_name": "Docking protein 6",
        "gene_name": "DOK6",
        "organism": "Human",
        "refseq_name": "docking protein 6",
        "refseq_ac": "NP_689934",
        "gene_names_uniprotkb": "DOK6; DOK5L",
        "gene_names_refseq": "DOK5L; DOK6; HsT3226",
        "protein_names_uniprotkb": "Docking protein 6; Downstream of tyrosine kinase 6",
        "protein_names_refseq": "docking protein 6; downstream of tyrosine kinase 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:220164);  (R-HSA-8853659)",
        "pathway_count": 2,
        "publication_count": 36,
        "publication_id_list": "10448070;10995764;11000521;11002419;11237011;11237712;11360177;11390647;11470823;11491658;11886862;12242309;12771945;14766744;15044950;15286081;15569713;20210798;29557506;31844290;34545688;35051231;7665556;8628282;8631863;8637703;8662982;8663426;8674117;9047384;9192684;9299438;9407096;9491986;9764818;9883723",
        "class_list": "",
        "function": "Association between ABHD1 and DOK6 polymorphisms and susceptibility to Hirschsprung disease in Southern Chinese children., [RefSeq, PubMed]; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance., [UniProtKB, PubMed]; DOK-6 is involved in RET signaling with less influence when compared with DOK-1, DOK-4, and SHC., [RefSeq, PubMed]; DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]., [RefSeq]; Dok-6 binds to the phosphorylated Ret Tyr(1062) residue resulting in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predominantly through a Src-dependent mechanism, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NNG3;Q4V9S3;Q8WUZ8;Q96HI2;Q96LU2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0035591 signaling adaptor activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q6PKX4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P62979-1",
        "uniprot_id": "RS27A_HUMAN",
        "mass": 17965.0,
        "length": 156,
        "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein",
        "gene_name": "RPS27A",
        "organism": "Human",
        "refseq_name": "ubiquitin-ribosomal protein eS31 fusion protein precursor",
        "refseq_ac": "NP_001129064",
        "gene_names_uniprotkb": "RPS27A; UBA80; UBCEP1",
        "gene_names_refseq": "CEP80; HEL112; RPS27A; S27A; UBA80; UBCEP1; UBCEP80; eS31",
        "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eS31 fusion protein; 40S ribosomal protein S27a; Ubiquitin carboxyl extension protein 80",
        "protein_names_refseq": "epididymis luminal protein 112; ubiquitin and ribosomal protein S27a; ubiquitin carboxyl extension protein 80; ubiquitin-40S ribosomal protein S27a; ubiquitin-CEP80; ubiquitin-ribosomal protein eS31 fusion protein precursor; ubiquitin-ribosomal protein eS31 fusion protein",
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        "function": "Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797)., [UniProtKB, PubMed, PubMed, PubMed]; Component of the 40S subunit of the ribosome. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling., [UniProtKB, PubMed, PubMed, PubMed]; Multifaceted functions of RPS27a: An unconventional ribosomal protein. Review article, [RefSeq, PubMed]; PICT1 is critical for regulating the Rps27a-Mdm2-p53 pathway by microtubule polymerization inhibitor against cervical cancer., [RefSeq, PubMed]; RPS27a and RPL40, Which Are Produced as Ubiquitin Fusion Proteins, Are Not Essential for p53 Signalling. Publication Status: Online-Only, [RefSeq, PubMed]; UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair., [RefSeq, PubMed]; Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P02248;P02249;P02250;P14798;P62988;Q29120;Q6LBL4;Q6LDU5;Q8WYN8;Q91887;Q91888;Q9BQ77;Q9BWD6;Q9BX98;Q9UEF2;Q9UEG1;Q9UEK8;Q9UPK7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006412 translation;GO:0019941 modification-dependent protein catabolic process;GO:0002181 cytoplasmic translation",
        "synthesized_glycan_count": 0,
        "hit_score": 349.5,
        "record_id": "P62979-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UBX8-1",
        "uniprot_id": "B4GT6_HUMAN",
        "mass": 44914.0,
        "length": 382,
        "protein_name": "Beta-1,4-galactosyltransferase 6",
        "gene_name": "B4GALT6",
        "organism": "Human",
        "refseq_name": "beta-1,4-galactosyltransferase 6 isoform 2",
        "refseq_ac": "NP_001317499",
        "gene_names_uniprotkb": "B4GALT6",
        "gene_names_refseq": "B4GALT6; B4Gal-T6; beta4Gal-T6",
        "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 6; 2.4.1.-; 2.4.1.274; Beta-1,4-GalTase 6; Beta4Gal-T6; Glucosylceramide beta-1,4-galactosyltransferase; LacCer synthase; Lactosylceramide synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6; UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6; b4Gal-T6",
        "protein_names_refseq": "UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6; UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6; beta-1,4-GalTase 6; beta-1,4-galactosyltransferase 6 isoform 2; beta4GalT-VI; lacCer synthase; lactosylceramide synthase",
        "tax_id": 9606,
        "disease": "multiple sclerosis (Disease Ontology:DOID:2377)",
        "pathway": " (hsa:9331);  (R-HSA-2022854);  (R-HSA-913709);  (R-HSA-975577);  (R-HSA-9840309)",
        "pathway_count": 5,
        "publication_count": 112,
        "publication_id_list": "10.1101/2023.09.13.557529;10206952;10320813;10330415;10395745;10430883;10491328;10504389;10570912;10580128;10601645;10700233;10748143;10753916;10766765;10993897;11018043;11030741;11042166;11042394;11237011;11283017;11304796;11421344;11425186;11530204;11588157;11821425;11901181;11956206;12097641;12180132;12218059;12222957;12603328;12668675;12765789;12815231;12855678;12888565;1329093;15486459;1551920;15560372;15620693;15939404;1601877;16434023;16924681;16934889;17006639;17021253;17113861;1714903;17488527;18537974;18931531;19403558;20117844;20547865;2118655;22183981;22735313;23290777;23746551;23882130;24190977;24498430;24643043;24715725;25502872;26811146;28904123;29802621;30315122;3099851;31844290;32350084;32357974;33298915;33912179;33968037;34357683;34982351;35051231;35154160;35251023;35494241;38034954;7655172;7876235;7890749;8333853;8611500;8643456;8830034;8910600;8920913;9030544;9054414;9125199;9199191;9295285;9394011;9405439;9417100;9435216;9582303;9597550;9822625;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:1551920, PubMed:24498430, PubMed:3099851). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Genomic organization and mapping of beta 4GalT-VIb to human chromosome 18q12.1, [RefSeq, PubMed]; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids., [UniProtKB, UniProtKB]; This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes in human. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. This gene produces multiple protein isoforms - some of which are predicted to lack the N-terminal hydrophobic signal sequence and transmembrane domain. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The canonical enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Jan 2020]., [RefSeq]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 7,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 388,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60514;Q6NT09",
        "ec_number_list": "2.4.1.-;2.4.1.274;2.4.1.275;2.4.1.38;2.4.1.90;2.4.1.22",
        "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane",
        "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0022010 central nervous system myelination;GO:0005975 carbohydrate metabolic process;GO:0021955 central nervous system neuron axonogenesis;GO:0001572 lactosylceramide biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "Q9UBX8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q67FW5-1",
        "uniprot_id": "QTGAL_HUMAN",
        "mass": 39394.0,
        "length": 346,
        "protein_name": "Queuosine-tRNA galactosyltransferase",
        "gene_name": "QTGAL",
        "organism": "Human",
        "refseq_name": "queuosine-tRNA galactosyltransferase isoform a",
        "refseq_ac": "NP_001009905",
        "gene_names_uniprotkb": "QTGAL; B3GNT8; B3GNTL1",
        "gene_names_refseq": "3-Gn-T8; B3GNT8; B3GNTL1; BGnT-8; QTGAL; beta-1; beta3Gn-T8; beta3GnTL1",
        "protein_names_uniprotkb": "Queuosine-tRNA galactosyltransferase; 2.4.1.-; BGnT-8; BGnT-like protein 1; Beta-1,3-Gn-T8; Beta-1,3-N-acetylglucosaminyltransferase 8; Beta1,3-N-acetylglucosaminyltransferase-like protein 1; Beta3Gn-T-like protein 1; Beta3Gn-T8; Beta3GnTL1; QTGAL; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1",
        "protein_names_refseq": "BGnT-like protein 1; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1; beta-1,3-Gn-T8; beta1,3-N-acetylglucosaminyltransferase-like protein 1; beta3Gn-T-like protein 1; queuosine-tRNA galactosyltransferase isoform a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:146712);  (R-HSA-913709)",
        "pathway_count": 2,
        "publication_count": 32,
        "publication_id_list": "10330415;10430883;10753916;11042166;11237011;11283017;11304796;11821425;12855678;1329093;15486459;15560372;15620693;17113861;18537974;22183981;24643043;25418920;25892735;28832583;29242379;29632046;29769354;37992713;38253038;7655172;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Beta3-GnTL1 is similar to beta1, 3-N-acetylglucosaminyltransferase, [RefSeq, PubMed]; Glycosyltransferase that specifically catalyzes galactosylation of cytoplasmic tRNA(Tyr) modified with queuosine at position 34 (queuosine(34)) (PubMed:37992713). Galactosylates the cyclopentene hydroxyl group of queuosine(34) in tRNA(Tyr) to form galactosyl-queuosine(34) (PubMed:37992713). Mannosylation of queuosine(34) in tRNA(Tyr) is required to slow-down elongation at cognate codons UAC and suppress stop codon readthrough, thereby regulating protein translation (PubMed:37992713)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 448,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6GV30;Q8WUT3",
        "ec_number_list": "2.4.1.-;2.4.1.147;2.4.1.149;2.4.1.206;2.4.1.146",
        "go_molecular_function": "GO:0141125 tRNA-queuosine(34) galactosyltransferase activity;GO:0016757 glycosyltransferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006417 regulation of translation;GO:0006400 tRNA modification;GO:0002099 tRNA wobble guanine modification",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q67FW5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NI38-1",
        "uniprot_id": "IKBD_HUMAN",
        "mass": 33481.0,
        "length": 313,
        "protein_name": "NF-kappa-B inhibitor delta",
        "gene_name": "NFKBID",
        "organism": "Human",
        "refseq_name": "NF-kappa-B inhibitor delta isoform 4",
        "refseq_ac": "NP_001352634",
        "gene_names_uniprotkb": "NFKBID; IKBNS",
        "gene_names_refseq": "IkBNS; IkappaBNS; NFKBID; TA-NFKBH",
        "protein_names_uniprotkb": "NF-kappa-B inhibitor delta; I-kappa-B-delta; IkB-delta; IkappaBNS; IkappaBdelta; NFKB inhibitor delta; T-cell activation NFKB-like protein; TA-NFKBH",
        "protein_names_refseq": "I-kappa-B-delta; NF-kappa-B inhibitor delta isoform 4; NF-kappa-B inhibitor delta; T-cell activation NFKB-like protein; ikB-delta; ikappaBdelta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84807)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;15177553;23481700;24714562;25349408;25892735;29557506;31217245;31844290;33912179;35051231;36581221",
        "class_list": "",
        "function": "Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced negative selection of thymocytes., [UniProtKB, UniProtKB]; The unique ability of p100/IkappaBdelta to stably interact with all NF-kappaB subunits by forming kappaBsomes demonstrates its importance in sequestering NF-kappaB subunits and releasing them as dictated by specific stimuli for developmental programs., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NI39;Q9BRG9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:2000321 positive regulation of T-helper 17 cell differentiation;GO:0006954 inflammatory response;GO:0050852 T cell receptor signaling pathway;GO:0010468 regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q8NI38-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y6D6-1",
        "uniprot_id": "BIG1_HUMAN",
        "mass": 208767.0,
        "length": 1849,
        "protein_name": "Brefeldin A-inhibited guanine nucleotide-exchange protein 1",
        "gene_name": "ARFGEF1",
        "organism": "Human",
        "refseq_name": "brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform 1",
        "refseq_ac": "NP_006412",
        "gene_names_uniprotkb": "ARFGEF1; ARFGEP1; BIG1",
        "gene_names_refseq": "ARFGEF1; ARFGEP1; BIG1; DEDISB; P200",
        "protein_names_uniprotkb": "Brefeldin A-inhibited guanine nucleotide-exchange protein 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1; Brefeldin A-inhibited GEP 1; p200 ARF guanine nucleotide exchange factor; p200 ARF-GEP1",
        "protein_names_refseq": "ADP ribosylation factor guanine nucleotide exchange factor 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform 1; brefeldin A-inhibited guanine nucleotide-exchange protein 1; p200 ARF guanine nucleotide exchange factor",
        "tax_id": 9606,
        "disease": "developmental delay, impaired speech, and behavioral abnormalities, with or without seizures (MONDO:MONDO:0859263)",
        "pathway": " (hsa:10565)",
        "pathway_count": 1,
        "publication_count": 100,
        "publication_id_list": "10212200;10393931;10716990;11237011;12571360;12606707;14973189;15644318;16467138;16959974;17081983;17227842;17360629;17640864;18292223;18452278;18669648;18691976;18707149;19332778;19413330;19651622;19651892;19664994;20058876;20068231;20360857;21406692;22084092;23186163;23481700;23572552;24275569;24715725;25576301;25645385;25892735;26154972;26375851;26992070;27090790;27373159;27436755;27600516;27846572;27862975;27920218;28218747;28228285;28411811;28832583;28834231;29242379;29393594;29437277;29493099;29508533;29557506;29632711;29786170;30315122;30410026;30429286;30484775;30524438;31217245;31678406;31844290;32157095;32350084;32357974;32387766;32488085;32897882;32938616;32983136;33298915;33592498;33717175;33912179;33936100;33968037;34087483;34113008;34171305;34357683;34405274;34509645;34725712;34932366;35048795;35051231;35154160;35251023;35580925;36010968;36241641;36284347;37074911;39302247",
        "class_list": "",
        "function": "ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]., [RefSeq]; Haploinsufficiency of ARFGEF1 is associated with developmental delay, intellectual disability, and epilepsy with variable expressivity., [RefSeq, PubMed]; Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The miR-133b/brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1) axis represses proliferation, invasion, and migration in cervical cancer cells., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NV46;Q9UFV2;Q9UNL0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0017022 myosin binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0034237 protein kinase A regulatory subunit binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0005829 cytosol",
        "go_biological_process": "GO:0015031 protein transport;GO:0031175 neuron projection development;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0009101 glycoprotein biosynthetic process;GO:0090303 positive regulation of wound healing",
        "synthesized_glycan_count": 0,
        "hit_score": 10.6,
        "record_id": "Q9Y6D6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NWD9-1",
        "uniprot_id": "BEX4_HUMAN",
        "mass": 14067.0,
        "length": 120,
        "protein_name": "Protein BEX4",
        "gene_name": "BEX4",
        "organism": "Human",
        "refseq_name": "protein BEX4",
        "refseq_ac": "NP_001073894",
        "gene_names_uniprotkb": "BEX4; BEXL1; NADE3",
        "gene_names_refseq": "BEX4; BEXL1",
        "protein_names_uniprotkb": "Protein BEX4; BEX1-like protein 1; Brain-expressed X-linked protein 4; Nerve growth factor receptor-associated protein 3",
        "protein_names_refseq": "BEX family member 4; BEX1-like protein 1; brain expressed X-linked-like 1; nerve growth factor receptor-associated protein 3; protein BEX4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56271)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "15958283;27297407;27512957;27920218;29493099;29660335;30367032;33217815",
        "class_list": "",
        "function": "Aberrant brain-expressed X-linked 4 (BEX4) expression is a novel prognostic biomarker in gastric cancer., [RefSeq, PubMed]; BEX4 overexpression causes an imbalance between TUB acetylation and deacetylation by SIRT2 inhibition and induces oncogenic aneuploidy transformation. Publication Status: Online-Only, [RefSeq, PubMed]; BEX4 positively regulated the expression of OCT4, silencing of which reduced the proliferation of A549 and H1975cells with over-expressed BEX4., [RefSeq, PubMed]; May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability (PubMed:27512957). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity)., [UniProtKB, PubMed, UniProtKB]; Study provides evidence that BEX4 functions as tumor suppressor by inhibiting proliferation and growth of oral squamous cell carcinoma (OSCC). Decreased BEX4 contributes to the increased proliferative propensity of OSCC. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest that the oncogenicity of BEX4 is conferred by PLK1-mediated phosphorylation, and thus, the BEX4-PLK1 interaction is a novel oncogenic signal that enables the acquisition of chromosomal aneuploidy. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0042826 histone deacetylase binding;GO:0043014 alpha-tubulin binding;GO:0140678 molecular function inhibitor activity",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0007059 chromosome segregation;GO:0042127 regulation of cell population proliferation;GO:0030334 regulation of cell migration;GO:0031397 negative regulation of protein ubiquitination;GO:1904428 negative regulation of tubulin deacetylation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q9NWD9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NXR7-2",
        "uniprot_id": "BABA2_HUMAN",
        "mass": 43552.0,
        "length": 383,
        "protein_name": "BRISC and BRCA1-A complex member 2",
        "gene_name": "BABAM2",
        "organism": "Human",
        "refseq_name": "BRISC and BRCA1-A complex member 2 isoform 4",
        "refseq_ac": "NP_001248769",
        "gene_names_uniprotkb": "BABAM2; BRCC45; BRE",
        "gene_names_refseq": "BABAM2; BRCC45; BRCC4; BRE",
        "protein_names_uniprotkb": "BRISC and BRCA1-A complex member 2; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein",
        "protein_names_refseq": "BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; BRCA1/BRCA2-containing complex, subunit 4; BRISC and BRCA1-A complex member 2 isoform 4; brain and reproductive organ-expressed (TNFRSF1A modulator); brain and reproductive organ-expressed protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9577);  (R-HSA-5689901);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-69473)",
        "pathway_count": 6,
        "publication_count": 252,
        "publication_id_list": "10.1101/2023.09.13.557529;10383417;10550055;10572166;10724175;10757784;10766245;10802669;10859164;10866324;10959836;10973490;11025670;11080452;11114888;11139606;11301010;11376695;11390408;11390642;11493912;11571274;11573085;11604075;11676476;11702069;11893489;11927591;11934988;11955432;12023295;12077346;12152085;12186630;12231622;12353037;12364621;12447390;12485996;12509254;12545175;12578958;12607003;12607005;12697768;12773400;12791985;12792649;12832489;12890688;12897153;12947387;14560035;14561766;14576433;14636569;15064416;15177042;15189136;15190204;15201865;15279782;15451442;15465831;15468306;15574327;15707391;15723659;16061182;16093244;16148040;16150728;16153896;16327781;16360315;16377563;16427009;16439204;16439205;16530042;16600297;16651405;16874298;16885023;16914548;17290226;17470781;17525332;17525340;17525341;17553757;17575048;17704801;17707232;17848578;17928296;17965729;18001824;18001825;18006705;18046455;18077395;18171670;18397950;18443292;18644861;18691976;18758443;18805091;18923075;18971343;19001859;19092802;19117993;19176521;19202061;19203578;19203579;19214193;19234442;19261746;19261748;19261749;19351884;19357644;19419957;19505854;19782031;20016603;20023648;20068231;20154705;20233725;20351172;21052091;21240188;21263215;21282113;21293379;21325134;21335604;21659603;21680713;21777809;22021381;22024395;22179609;22223895;22231403;22234877;22373579;22424782;22508508;22529269;22589545;22635276;22661229;22661230;22792074;22908299;22977173;22980979;23186163;23246432;23306437;23333306;23345434;23468639;23481700;23505375;23727112;24075985;24236237;24366607;24667604;24715725;25113031;25122754;25283148;25418920;25505266;25512557;25558984;25576301;25659039;25802875;25818648;25841101;26154972;26195665;26375851;26992070;27846572;28904123;29437277;29493099;29557506;30315122;30410026;30429286;30484775;30779550;30833945;31154438;31217245;31530632;31844290;31848261;31937595;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33912179;33968037;34087483;34171305;34405274;34932366;35051231;35154160;35251023;35318648;35561310;35580925;36010968;36172813;36215666;36284347;37938771;40914422;7826398;8422676;8944023;9168116;9259561;9430729;9488723;9512523;9705271;9826654",
        "class_list": "",
        "function": "Antiapoptotic in vivo; Bre levels are regulated post-transcriptionally in the liver, which is not observed in human hepatocellular carcinoma (HCC) and non-HCC cell lines., [RefSeq, PubMed]; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261748, PubMed:19261749). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:19261748, PubMed:21282113). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer. [provided by RefSeq, Jun 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4X1;D6W562;D6W563;Q13880;Q4ZFX8;Q53SD0;Q969X9;Q96P06",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0000268 peroxisome targeting sequence binding;GO:0005164 tumor necrosis factor receptor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070552 BRISC complex",
        "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0070536 protein K63-linked deubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 25.7,
        "record_id": "Q9NXR7-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P287-1",
        "uniprot_id": "BCCIP_HUMAN",
        "mass": 35979.0,
        "length": 314,
        "protein_name": "BRCA2 and CDKN1A-interacting protein",
        "gene_name": "BCCIP",
        "organism": "Human",
        "refseq_name": "BRCA2 and CDKN1A-interacting protein isoform BCCIPalpha",
        "refseq_ac": "NP_057651",
        "gene_names_uniprotkb": "BCCIP; TOK1",
        "gene_names_refseq": "BCCIP; TOK-1; TOK1",
        "protein_names_uniprotkb": "BRCA2 and CDKN1A-interacting protein; P21- and CDK-associated protein 1; Protein TOK-1",
        "protein_names_refseq": "BCCIPalpha; BCCIPbeta; BRCA2 and CDKN1A-interacting protein isoform BCCIPalpha; BRCA2 and Cip1/p21 interacting protein; TOK-1alpha; TOK-1beta; cdk inhibitor p21 binding protein; p21- and CDK-associated protein 1; protein TOK-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56647)",
        "pathway_count": 1,
        "publication_count": 74,
        "publication_id_list": "10878006;11313963;11748848;11754111;11836363;12527204;14726710;15539944;15713648;17081983;17287340;17947333;18440304;18452278;19651622;20068231;21406692;23301498;23481700;24275569;25548167;25576301;25645385;26154972;26811146;28228285;28394342;28446606;28510447;28514659;28832583;28904123;28931820;29242379;29557506;29930882;30315122;30779550;30833945;31092671;31154438;31492838;31530632;31844290;31998317;32157095;32161166;32350084;32357974;32488085;32502341;32897882;32938616;32983136;33214551;33245766;33298915;33452718;33537174;33691108;33968037;33981976;34019948;34171305;34297484;34357683;35051231;35580925;36010968;36241641;37938771;38342812;40596516;40914422",
        "class_list": "",
        "function": "BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis., [RefSeq, PubMed]; BRCA2 germline mutations appear to have a milder clinical phenotype when compared to non-BRCA2 mutations, since survival is higher among breast cancer patients carrying a BRCA2 mutation compared to sporadic breast cancers., [RefSeq, PubMed]; During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Expression and Significance of BCCIP and Glutathione Peroxidase 4 in Clear Cell Renal Cell Carcinoma., [RefSeq, PubMed]; In BRCA2, two novel frame shift mutations were identified as 5073-5074delCT and 6866delC., [RefSeq, PubMed]; Overexpression of BCCIP predicts an unfavorable prognosis and promotes the proliferation and migration of lung adenocarcinoma., [RefSeq, PubMed]; Structure of human BCCIP and implications for binding and modification of partner proteins., [RefSeq, PubMed]; This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Unique de novo mutation of BRCA2 has been identified in a woman with early onset breast cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KP45;Q8ND15;Q96GC4;Q9P288",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0015631 tubulin binding;GO:0019207 kinase regulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005814 centriole;GO:0097431 mitotic spindle pole",
        "go_biological_process": "GO:0006281 DNA repair;GO:0090307 mitotic spindle assembly;GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000226 microtubule cytoskeleton organization;GO:0000132 establishment of mitotic spindle orientation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.7,
        "record_id": "Q9P287-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UHR4-1",
        "uniprot_id": "BI2L1_HUMAN",
        "mass": 56883.0,
        "length": 511,
        "protein_name": "BAR/IMD domain-containing adapter protein 2-like 1",
        "gene_name": "BAIAP2L1",
        "organism": "Human",
        "refseq_name": "BAR/IMD domain-containing adapter protein 2-like 1",
        "refseq_ac": "NP_061330",
        "gene_names_uniprotkb": "BAIAP2L1; IRTKS",
        "gene_names_refseq": "BAIAP2L1; IRTKS",
        "protein_names_uniprotkb": "BAR/IMD domain-containing adapter protein 2-like 1; BAI1-associated protein 2-like protein 1; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate",
        "protein_names_refseq": "BAI1 associated protein 2 like 1; BAI1-associated protein 2-like protein 1; BAR/IMD domain-containing adapter protein 2-like 1; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55971);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013423);  (R-HSA-9035034)",
        "pathway_count": 5,
        "publication_count": 328,
        "publication_id_list": "10.1101/2023.09.13.557529;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10618392;10699171;10699464;10847683;10873802;10931946;10958683;11007481;11058585;11085924;11145705;11149925;11373293;11396949;11431473;11432776;11584276;11672528;11704860;11707441;11756552;11773441;11803464;11804587;11804589;11804590;11884391;11912491;11919634;11956649;11961559;12071859;12093360;12096337;12195014;12221096;12351724;12432077;12531887;12546821;12547822;12650940;12665586;12857875;12877655;12923183;14512443;14514689;1464587;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15147912;15169870;15302923;15339924;15342493;15485661;15507211;15542837;15579468;15601624;15611138;15728722;15814684;15850391;15858067;15897194;16002401;16081809;16112081;16116428;16184169;16243035;16243036;16473593;16492808;16507994;16519628;1660188;16636067;16702231;16762923;16777452;16777849;16862148;16896804;16914516;16968698;17060455;17077126;17081983;17145773;17158234;17196961;17214551;17244649;17269730;17322306;17430976;17583407;17599059;17698854;17702745;17765681;17804252;17976533;18006505;18045877;18056264;18191593;18212344;18218625;18220336;18249095;18347018;18396277;18426980;18452278;18491316;18653540;18662984;18669648;18697831;18707149;18767875;18838382;19269969;19366662;19413330;19415658;19494238;19534724;19605563;19651622;19664994;19664995;19673492;19713215;19807924;19934221;20058876;20068230;20068231;20233848;20400958;20460433;20679435;20810653;21098279;21119010;21148482;21151158;21378159;21542010;21565175;21613211;21730051;21840312;21865595;21989057;22004470;22096251;22298643;22407364;22475431;22608513;22734669;22921828;22970203;23096567;23186163;23209303;23255595;23288169;23301498;23434736;23481700;23572525;23707487;23718289;23757206;23870057;23940355;24086303;24259668;24275569;24335996;24352656;24623723;24715725;24859002;24933155;24960694;25024229;25211221;25428919;25668492;25704760;25721503;25795300;25862245;26016997;26129894;26529257;26628301;26887924;26992070;27117132;27145964;27216196;27278019;27481945;27555588;27566826;27600516;27713499;27806292;27846572;28114311;28196833;28218747;28228285;28356423;28514659;28647685;28832583;28834231;28904123;29089502;29242379;29358323;29382922;29393594;29437277;29508533;29557506;29786170;30315122;30410026;30429286;30779550;30833945;30853411;31154438;31217245;31373491;31389670;31530632;31844290;31871319;32157095;32161166;32203420;32350084;32357974;32488085;32938616;33537174;33912179;33968037;33981976;34087483;34171305;34185709;34561969;35051231;35580925;36010968;36057038;36241641;36284347;36308067;38869721;39192031;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8643598;8645157;8662891;8756646;8769096;8798539;8805223;8810315;8816443;8939998;8990121;8994827;9013646;9099726;9113980;9252344;9305890;9438849;9490638;9497316;9582072;9659915;9670022;9705280;9792683;9822598;9843499;9988689",
        "class_list": "",
        "function": "BAIAP2L1 accelerates breast cancer progression and chemoresistance by activating AKT signaling through binding with ribosomal protein L3., [RefSeq, PubMed]; Heterochromatin formation and remodeling by IRTKS condensates counteract cellular senescence., [RefSeq, PubMed]; IRTKS contributes to the malignant progression of cervical cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; Insulin receptor tyrosine kinase substrate (IRTKS) promotes the tumorigenesis of pancreatic cancer via PI3K/AKT signaling., [RefSeq, PubMed]; May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection., [UniProtKB, PubMed, PubMed, PubMed]; Study characterised IRTKS, which has widespread tissue distribution, is a substrate for the insulin receptor and binds Rac, and expression of IRTKS induces clusters of short actin bundles rather than filopodia-like protrusions., [RefSeq, PubMed]; This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 25,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D268;Q75L21;Q75L22;Q96CV4;Q9H5F5;Q9Y2M8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0070064 proline-rich region binding;GO:0098641 cadherin binding involved in cell-cell adhesion",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction",
        "go_biological_process": "GO:0007009 plasma membrane organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0051764 actin crosslink formation;GO:0030838 positive regulation of actin filament polymerization",
        "synthesized_glycan_count": 0,
        "hit_score": 33.7,
        "record_id": "Q9UHR4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UIG0-1",
        "uniprot_id": "BAZ1B_HUMAN",
        "mass": 170903.0,
        "length": 1483,
        "protein_name": "Tyrosine-protein kinase BAZ1B",
        "gene_name": "BAZ1B",
        "organism": "Human",
        "refseq_name": "tyrosine-protein kinase BAZ1B",
        "refseq_ac": "NP_115784",
        "gene_names_uniprotkb": "BAZ1B; WBSC10; WBSCR10; WBSCR9; WSTF",
        "gene_names_refseq": "BAZ1B; WBSCR10; WBSCR9; WSTF",
        "protein_names_uniprotkb": "Tyrosine-protein kinase BAZ1B; 2.7.10.2; Bromodomain adjacent to zinc finger domain protein 1B; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; hWALp2",
        "protein_names_refseq": "hWALp2; transcription factor WSTF; tyrosine-protein kinase BAZ1B; williams syndrome transcription factor; williams-Beuren syndrome chromosomal region 10 protein; williams-Beuren syndrome chromosomal region 9 protein",
        "tax_id": 9606,
        "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)",
        "pathway": " (hsa:9031);  (R-HSA-5250924);  (R-HSA-5693565)",
        "pathway_count": 3,
        "publication_count": 217,
        "publication_id_list": "10.1101/2023.09.13.557529;10550055;10662543;10724175;10766245;10802669;10866324;10959836;10973490;11025670;11114888;11124022;11390408;11571274;11573085;11893489;11927591;11934988;11980720;12364621;12447390;12485996;12607003;12607005;12697768;12773400;12792649;12832489;12890688;14560035;15064416;15201865;15279782;15302935;15543136;15558034;16150728;16252006;16377563;16427009;16514417;16565220;16603771;16651405;17081983;17525332;17525340;17553757;17848578;18001824;18001825;18006705;18077395;18162579;18443292;18452278;18491316;18644861;18669648;18691976;18707149;18991276;19001859;19007248;19092802;19117993;19176521;19203578;19203579;19234442;19261749;19351884;19413330;19415658;19651622;19664995;19690332;19691289;19776015;19782031;20016603;20023648;20068230;20068231;20112406;20351172;21282113;21293379;21406692;21559432;21872626;21993680;22234877;22373579;22424782;22508508;22589545;22645359;22908299;22980979;23186163;23481700;23555303;23667505;24275569;24366607;24667604;24714562;24715725;24901984;24952918;25114211;25218447;25418920;25576301;25593309;25645385;25755297;25802875;25880248;25892735;26024233;26154972;26375851;26728094;26811146;26929215;26992070;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28514659;28801535;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30192525;30315122;30379171;30410026;30429286;30524438;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34028125;34078123;34087483;34171305;34185709;34211107;34405274;34509645;34561969;34784707;34932366;35051231;35494241;35561310;35580925;35850772;36010968;36215666;36241641;36284347;36581221;37938771;8944023;9168116;9488723;9828126;9858827",
        "class_list": "",
        "function": "Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008]., [RefSeq]; Williams syndrome transcription factor promotes proliferation and invasion of cervical cancer cells by regulating PI3K/Akt signaling pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 38,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EGK3;D3DXE9;O95039;O95247;O95277;Q6P1K4;Q86UJ6",
        "ec_number_list": "2.7.12.2;2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;3.6.4.-;2.7.7.6;2.7.1.40;2.7.1.32;2.7.1.82;2.7.10.4;2.7.11.26;2.7.11.24;2.7.11.13;2.3.1.48;2.3.1.-;2.7.11.23;2.3.1.57;3.6.4.13",
        "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0035173 histone kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000793 condensed chromosome;GO:0005721 pericentric heterochromatin",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043687 post-translational protein modification;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 22.2,
        "record_id": "Q9UIG0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9ULI0-1",
        "uniprot_id": "ATD2B_HUMAN",
        "mass": 164942.0,
        "length": 1458,
        "protein_name": "ATPase family AAA domain-containing protein 2B",
        "gene_name": "ATAD2B",
        "organism": "Human",
        "refseq_name": "ATPase family AAA domain-containing protein 2B isoform 2",
        "refseq_ac": "NP_001229267",
        "gene_names_uniprotkb": "ATAD2B; KIAA1240",
        "gene_names_refseq": "ATAD2B",
        "protein_names_uniprotkb": "ATPase family AAA domain-containing protein 2B",
        "protein_names_refseq": "ATPase family AAA domain-containing protein 2B isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54454)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "11237011;20068231;21158754;21406692;22464331;23186163;23481700;24275569;24561620;25418920;25576301;25593309;25645385;25892735;26929215;27920218;28228285;28514659;28832583;28834231;29242379;29331515;29393594;29632046;29632711;29769354;30315122;30524438;37217939",
        "class_list": "",
        "function": "The ATAD2B may play a role in neuronal differentiation and tumor progression., [RefSeq, PubMed]; The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9ZVQ5;Q6ZNA6;Q8N9E7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding;GO:0140566 histone reader activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0006334 nucleosome assembly;GO:0006337 nucleosome disassembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q9ULI0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y679-2",
        "uniprot_id": "AUP1_HUMAN",
        "mass": 45787.0,
        "length": 410,
        "protein_name": "Lipid droplet-regulating VLDL assembly factor AUP1",
        "gene_name": "AUP1",
        "organism": "Human",
        "refseq_name": "lipid droplet-regulating VLDL assembly factor AUP1",
        "refseq_ac": "NP_853553",
        "gene_names_uniprotkb": "AUP1",
        "gene_names_refseq": "AUP1",
        "protein_names_uniprotkb": "Lipid droplet-regulating VLDL assembly factor AUP1; Ancient ubiquitous protein 1",
        "protein_names_refseq": "ancient ubiquitous protein 1; lipid droplet-regulating VLDL assembly factor AUP1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:550);  (R-HSA-9918481)",
        "pathway_count": 2,
        "publication_count": 99,
        "publication_id_list": "11747608;12042322;14519844;14762106;15084397;18446792;18669648;18691976;18711132;19413330;20068231;21127063;21857022;21911577;22223895;22898188;23186163;23197321;23223569;24039768;25418920;25645385;26092250;27108190;27600516;27920218;28183703;28218747;28228285;28514659;28832583;28834231;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;29902443;30315122;30410026;30429286;30524438;30599162;30779550;31092671;31222486;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33177556;33298915;33392160;33537174;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34405274;34509645;34561969;34932366;35051231;35215846;35251023;35318648;35580925;35633317;36010968;36215666;36241641;36284347;37938771;38474353;39329209;40914422",
        "class_list": "",
        "function": "(Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles., [UniProtKB, PubMed]; AUP1 Regulates the Endoplasmic Reticulum-Associated Degradation and Polyubiquitination of NKCC2. Publication Status: Online-Only, [RefSeq, PubMed]; AUP1 regulates lipid metabolism and induces lipid accumulation to accelerate the progression of renal clear cell carcinoma., [RefSeq, PubMed]; AUP1 transcriptionally activated by KDM5B reprograms lipid metabolism to promote the malignant progression of cervical cancer., [RefSeq, PubMed]; Binding of Aup1 plays a crucial role in the alpha(IIb)beta(3) inside-out signaling, [RefSeq, PubMed]; Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control., [RefSeq, PubMed]; Monoubiquitinated AUP1 on the lipid droplet surface specifically induces clustering. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (PubMed:18711132, PubMed:21857022). Plays a role in lipid droplet formation (PubMed:21857022). Induces lipid droplet clustering (PubMed:24039768). Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (PubMed:21127063, PubMed:23223569). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (PubMed:23223569). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (PubMed:28183703)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The presence of the AUP1-Ube2g2 complex at LDs provides a direct molecular link between LDs and the cellular ubiquitination machinery., [RefSeq, PubMed]; The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 27,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C0H5W8;Q9H866;Q9UNQ6;Q9Y685",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0031624 ubiquitin conjugating enzyme binding;GO:0043130 ubiquitin binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0009615 response to virus;GO:0036503 ERAD pathway;GO:0034389 lipid droplet organization;GO:0140042 lipid droplet formation;GO:0030970 retrograde protein transport, ER to cytosol",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "Q9Y679-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y6D5-1",
        "uniprot_id": "BIG2_HUMAN",
        "mass": 202038.0,
        "length": 1785,
        "protein_name": "Brefeldin A-inhibited guanine nucleotide-exchange protein 2",
        "gene_name": "ARFGEF2",
        "organism": "Human",
        "refseq_name": "brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform 1",
        "refseq_ac": "NP_006411",
        "gene_names_uniprotkb": "ARFGEF2; ARFGEP2; BIG2",
        "gene_names_refseq": "ARFGEF2; BIG2; PVNH2; dJ1164I10.1",
        "protein_names_uniprotkb": "Brefeldin A-inhibited guanine nucleotide-exchange protein 2; ADP-ribosylation factor guanine nucleotide-exchange factor 2; Brefeldin A-inhibited GEP 2",
        "protein_names_refseq": "ADP ribosylation factor guanine nucleotide exchange factor 2; ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); brefeldin A-inhibited GEP 2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform 1; brefeldin A-inhibited guanine nucleotide-exchange protein 2",
        "tax_id": 9606,
        "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454); periventricular heterotopia with microcephaly, autosomal recessive (MONDO:MONDO:0011966)",
        "pathway": " (hsa:10564);  (R-HSA-390471)",
        "pathway_count": 2,
        "publication_count": 115,
        "publication_id_list": "10.1101/2023.09.13.557529;10212200;10716990;11237011;11665623;12051703;12502735;12571360;14647276;15302935;15385626;15705715;16477018;16866877;16959974;17081983;17276987;17322306;17360629;17525332;17640864;18452278;18625701;18669648;18691976;18767875;18775504;19007248;19011634;19332778;19369195;19413330;19651622;19664994;19664995;19690332;19691289;20068231;20360857;21098288;21406692;21995946;23033978;23186163;23481700;23747015;23812912;24275569;24715725;24756126;25160555;25342745;25418920;25467444;25645385;26154972;26375851;26992070;27162341;27600516;27846572;27862975;27920218;28218747;28228285;28649982;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29508533;29557506;29632711;29786170;30315122;30379171;30429286;30484775;30524438;30833945;31092671;31154438;31199673;31217245;31844290;31848261;31937595;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33592498;33912179;33968037;34171305;34290406;34357683;34509645;34932366;35051231;35580925;36010968;36241641;36284347;9819444",
        "class_list": "",
        "function": "ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]., [RefSeq]; BIG1 and BIG2 knockdown significantly decreased the levels of VEGF mRNA and protein in glioblastoma U251 cells and HUVECs. Furthermore, depletion of BIG1 and BIG2 inhibited HUVEC angiogenesis by diminishing cell migration., [RefSeq, PubMed]; Both phospholipase D activity and vesicular trafficking were required for effects of BIG1 and BIG2 on beta-catenin activation. Levels of PKA-phosphorylated beta-catenin S675 and beta-catenin association with PKA, BIG1, and BIG2 were also diminished after BIG1/BIG2 depletion., [RefSeq, PubMed]; Involvement in molecular mechanisms of vesicular transport, [RefSeq, PubMed]; Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 29,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 46,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TFT9;Q9NTS1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0017022 myosin binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0034237 protein kinase A regulatory subunit binding;GO:0050811 GABA receptor binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005813 centrosome",
        "go_biological_process": "GO:0015031 protein transport;GO:0035556 intracellular signal transduction;GO:0007032 endosome organization;GO:0032760 positive regulation of tumor necrosis factor production;GO:0001881 receptor recycling",
        "synthesized_glycan_count": 0,
        "hit_score": 12.0,
        "record_id": "Q9Y6D5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZWK4-1",
        "uniprot_id": "RHEX_HUMAN",
        "mass": 19405.0,
        "length": 172,
        "protein_name": "Regulator of hemoglobinization and erythroid cell expansion protein",
        "gene_name": "RHEX",
        "organism": "Human",
        "refseq_name": "regulator of hemoglobinization and erythroid cell expansion protein",
        "refseq_ac": "NP_001007545",
        "gene_names_uniprotkb": "RHEX; C1orf186",
        "gene_names_refseq": "C1orf186; RHEX",
        "protein_names_uniprotkb": "Regulator of hemoglobinization and erythroid cell expansion protein; Regulator of human erythroid cell expansion protein",
        "protein_names_refseq": "regulator of hemoglobinization and erythroid cell expansion protein; regulator of human erythroid cell expansion protein; uncharacterized protein C1orf186",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:440712)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;25092874;29557506;37174705",
        "class_list": "",
        "function": "Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation (PubMed:25092874)., [UniProtKB, PubMed]; Clorfl86/RHEX Is a Negative Regulator of SCF/KIT Signaling in Human Skin Mast Cells. Publication Status: Online-Only, [RefSeq, PubMed]; RHEX(C1orf186) comprises a new EPO/EPOR target and regulator of erythroid cell expansion that additionally acts to support late-stage erythroblast development Erratum:[J Exp Med. 2015 Jun 1;212(6):971. doi: 10.1084/jem.2013062404242015c. PMID: 25941257], [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005128 erythropoietin receptor binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0045648 positive regulation of erythrocyte differentiation;GO:0038162 erythropoietin-mediated signaling pathway;GO:0036018 cellular response to erythropoietin",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q6ZWK4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q12983-1",
        "uniprot_id": "BNIP3_HUMAN",
        "mass": 21541.0,
        "length": 194,
        "protein_name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3",
        "gene_name": "BNIP3",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "BNIP3; NIP3",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); transient cerebral ischemia (Disease Ontology:DOID:224); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:664)",
        "pathway_count": 1,
        "publication_count": 48,
        "publication_id_list": "10381623;11237011;15868100;18371312;19935772;20068231;22292033;22898188;23209295;24275569;25576301;25645385;26102349;26375851;26992070;27846572;27893789;27920218;28063628;28218747;28228285;28467828;28798696;28832583;28834231;28904123;29242379;29437277;29632046;29786170;30315122;30524438;31154438;31530632;31998317;32350084;32357974;32387766;33592498;33717175;34185709;34433824;36284347;37938771;38992176;7954800;9396766;9575197",
        "class_list": "",
        "function": "Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 10,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O14620;Q96GP0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051020 GTPase binding;GO:0140506 endoplasmic reticulum-autophagosome adaptor activity;GO:0140580 mitochondrion autophagosome adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0051402 neuron apoptotic process;GO:0051607 defense response to virus;GO:0001666 response to hypoxia",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q12983-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NLJ0-1",
        "uniprot_id": "C2C4B_HUMAN",
        "mass": 38769.0,
        "length": 364,
        "protein_name": "C2 calcium-dependent domain-containing protein 4B",
        "gene_name": "C2CD4B",
        "organism": "Human",
        "refseq_name": "C2 calcium-dependent domain-containing protein 4B",
        "refseq_ac": "NP_001007596",
        "gene_names_uniprotkb": "C2CD4B; FAM148B; NLF2",
        "gene_names_refseq": "C2CD4B; FAM148B; NLF2",
        "protein_names_uniprotkb": "C2 calcium-dependent domain-containing protein 4B; Nuclear-localized factor 2; Protein FAM148B",
        "protein_names_refseq": "C2 calcium-dependent domain-containing protein 4B; family with sequence similarity 148, member B; nuclear localized factor 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:388125)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "15527968;20081858;20185807;20419449;27329800;29625024;31154438;35051231;35212842;36834715",
        "class_list": "",
        "function": "C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population., [RefSeq, PubMed]; May be involved in inflammatory process. May regulate cell architecture and adhesion., [UniProtKB, PubMed]; Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) Erratum:[Nat Genet.2010 May;42(5):464], [RefSeq, PubMed]; NLF2 may play a role in regulating genes which control cellular architecture., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Rs7163757 contributes to genetic risk of islet dysfunction and type 2 diabetes by increasing NFAT-mediated islet enhancer activity and modulating C2CD4B, and possibly C2CD4A, expression in (patho)physiologic states., [RefSeq, PubMed]; Selective Transcription Factor Blockade Reduces Human Retinal Endothelial Cell Expression of Intercellular Adhesion Molecule-1 and Leukocyte Binding. Publication Status: Online-Only, [RefSeq, PubMed]; The present data thus provide evidence for a limited role for changes in VPS13C expression in conferring altered type 2 diabetes risk at this locus, particularly in females, and suggest that C2CD4A, but not C2CD4B, may also be involved., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
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        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
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        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0030155 regulation of cell adhesion;GO:0002675 positive regulation of acute inflammatory response;GO:0002528 regulation of vascular permeability involved in acute inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "A6NLJ0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MTZ0-1",
        "uniprot_id": "BBIP1_HUMAN",
        "mass": 10506.0,
        "length": 92,
        "protein_name": "BBSome-interacting protein 1",
        "gene_name": "BBIP1",
        "organism": "Human",
        "refseq_name": "BBSome-interacting protein 1 isoform 1",
        "refseq_ac": "NP_001182233",
        "gene_names_uniprotkb": "BBIP1; BBIP10; NCRNA00081",
        "gene_names_refseq": "BBIP10; BBIP1; BBS18; NCRNA00081; bA348N5.3",
        "protein_names_uniprotkb": "BBSome-interacting protein 1; BBSome-interacting protein of 10 kDa",
        "protein_names_refseq": "BBSome-interacting protein 1 isoform 1; BBSome-interacting protein of 10 kDa; UPF0604 protein",
        "tax_id": 9606,
        "disease": "Bardet-Biedl syndrome 18 (Disease Ontology:DOID:0110140)",
        "pathway": " (hsa:92482);  (R-HSA-5620922)",
        "pathway_count": 2,
        "publication_count": 25,
        "publication_id_list": "11237011;11252952;15258860;15314642;17574030;19081074;19421068;19575670;20080638;20233871;20603001;21427764;22072986;22139371;22389062;22500027;23351793;24026985;24296415;25443296;25446516;28228285;31844290;32357974;34357683",
        "class_list": "",
        "function": "Identification of BBIP1 as the 18th BBS gene (BBS18), BBSome assembly may represent a unifying pathomechanism for Bardet-Biedl syndrome., [RefSeq, PubMed]; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for primary cilia assembly and BBSome stability. Regulates cytoplasmic microtubule stability and acetylation., [UniProtKB, UniProtKB]; This gene encodes one of eight proteins that form the BBSome complex and is essential for its assembly. The BBSome complex is involved in trafficking signal receptors to and from the cilia. Mutations in this gene result in Bardet-Biedl syndrome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
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        "reported_phosphosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PIY9;E9PM41;E9PRI7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0036064 ciliary basal body;GO:0060170 ciliary membrane;GO:0034464 BBSome",
        "go_biological_process": "GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0097500 receptor localization to non-motile cilium",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "A8MTZ0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MVZ5-1",
        "uniprot_id": "BTNLA_HUMAN",
        "mass": 32612.0,
        "length": 291,
        "protein_name": "Putative butyrophilin-like protein 10",
        "gene_name": "BTNL10P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "BTNL10P; BTNL10",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative butyrophilin-like protein 10",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "32488085;34087483",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding",
        "go_cellular_component": "GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "A8MVZ5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MY62-1",
        "uniprot_id": "BLML_HUMAN",
        "mass": 63506.0,
        "length": 579,
        "protein_name": "Beta-lactamase-like protein 1",
        "gene_name": "LACTBL1",
        "organism": "Human",
        "refseq_name": "beta-lactamase-like protein 1",
        "refseq_ac": "NP_001276903",
        "gene_names_uniprotkb": "LACTBL1",
        "gene_names_refseq": "LACTBL1",
        "protein_names_uniprotkb": "Beta-lactamase-like protein 1",
        "protein_names_refseq": "beta-lactamase-like protein 1; putative beta-lactamase-like 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:646262)",
        "pathway_count": 1,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "predicted_c_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "H0Y608",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A8MY62-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P18075-1",
        "uniprot_id": "BMP7_HUMAN",
        "mass": 49313.0,
        "length": 431,
        "protein_name": "Bone morphogenetic protein 7",
        "gene_name": "BMP7",
        "organism": "Human",
        "refseq_name": "bone morphogenetic protein 7 preproprotein",
        "refseq_ac": "NP_001710",
        "gene_names_uniprotkb": "BMP7; OP1",
        "gene_names_refseq": "BMP7; OP-1",
        "protein_names_uniprotkb": "Bone morphogenetic protein 7; BMP-7; OP-1; Osteogenic protein 1",
        "protein_names_refseq": "bone morphogenetic protein 7 preproprotein; osteogenic protein 1",
        "tax_id": 9606,
        "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); prostate cancer (Disease Ontology:DOID:10283); pyelonephritis (Disease Ontology:DOID:11400); acute kidney tubular necrosis (Disease Ontology:DOID:12556); Marfan syndrome (Disease Ontology:DOID:14323); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); kidney disease (Disease Ontology:DOID:557); osteoarthritis (Disease Ontology:DOID:8398); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:655);  (R-HSA-2129379);  (R-HSA-9844594)",
        "pathway_count": 3,
        "publication_count": 56,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10025398;10424889;10544250;10646116;10930463;11237011;11970960;12358597;12415008;12429738;12478285;12667445;12927798;1400330;14701737;15020244;1708799;17324935;17977014;18184661;18339631;20506283;21646718;21924665;2263636;2357959;23584533;24190977;26992070;27923061;29557506;30097509;31154438;31208997;31844290;31848261;32157095;33308444;33592498;34171305;34185709;35051231;35580925;36284347;37074911;37688374;38259670;38651735;38753641;7500359;7534784;8570652;9725916;9748228",
        "class_list": "",
        "function": "Genetic predisposition of BMP7 polymorphisms to lumbar disk herniation in the Chinese Han population., [RefSeq, PubMed]; Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:12667445, PubMed:9748228). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; High BMP7 expression is associated with poor prognosis in ovarian cancer., [RefSeq, PubMed]; Impact of Bone Morphogenetic Protein 7 and Prostaglandin receptors on osteoblast healing and organization of collagen. Publication Status: Online-Only, [RefSeq, PubMed]; SCUBE1 promotes pulmonary artery smooth muscle cell proliferation and migration in acute pulmonary embolism by modulating BMP7. Publication Status: Online-Only, [RefSeq, PubMed]; The involvement of BMP7 in several pathological conditions, such as incomplete fracture healing, osteoarthritis, the development of bone metastases, renal fibrosis and obesity. Review article, [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 2,
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        "reported_snv": 24,
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        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 13,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9H512;Q9NTQ7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008201 heparin binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0031982 vesicle",
        "go_biological_process": "GO:0007507 heart development;GO:0010628 positive regulation of gene expression;GO:0016358 dendrite development;GO:0045665 negative regulation of neuron differentiation;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "P18075-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P00918-1",
        "uniprot_id": "CAH2_HUMAN",
        "mass": 29246.0,
        "length": 260,
        "protein_name": "Carbonic anhydrase 2",
        "gene_name": "CA2",
        "organism": "Human",
        "refseq_name": "carbonic anhydrase 2 isoform 1",
        "refseq_ac": "NP_000058",
        "gene_names_uniprotkb": "CA2",
        "gene_names_refseq": "CA-II; CA2; CAC; CAII; Car2; HEL-76; HEL-S-282",
        "protein_names_uniprotkb": "Carbonic anhydrase 2; 4.2.1.1; 4.2.1.69; CA-II; CAC; Carbonate dehydratase II; Carbonic anhydrase C; Carbonic anhydrase II; Cyanamide hydratase CA2",
        "protein_names_refseq": "carbonate dehydratase II; carbonic anhydrase 2 isoform 1; carbonic anhydrase B; carbonic anhydrase C; carbonic anhydrase II; carbonic dehydratase; cyanamide hydratase CA2; epididymis luminal protein 76; epididymis secretory protein Li 282",
        "tax_id": 9606,
        "disease": "autoimmune pancreatitis (Disease Ontology:DOID:0040091); chronic pancreatitis (Disease Ontology:DOID:0051065); colorectal carcinoma (Disease Ontology:DOID:0080199); autosomal recessive osteopetrosis 3 (Disease Ontology:DOID:0110941); primary biliary cholangitis (Disease Ontology:DOID:12236); Sjogren's syndrome (Disease Ontology:DOID:12894); osteopetrosis (Disease Ontology:DOID:13533); viral hepatitis (Disease Ontology:DOID:1884); Lynch syndrome (Disease Ontology:DOID:3883); bladder urothelial carcinoma (Disease Ontology:DOID:4006); alcoholic pancreatitis (Disease Ontology:DOID:4988); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074)",
        "pathway": " (hsa:760);  (R-HSA-1237044);  (R-HSA-1247673);  (R-HSA-1475029);  (R-HSA-9925563)",
        "pathway_count": 5,
        "publication_count": 213,
        "publication_id_list": "10090333;10409679;10529219;10550681;10611283;11015219;11076507;11121027;11237011;11327835;11572683;11606574;11676494;11802772;11818565;11831900;120192;12056894;12166932;12171926;12499545;12754312;12933803;1311094;1336460;1395;1433293;14567693;14611844;14736236;14736710;1474587;14958;15131110;15218065;15299481;15299482;15300855;1542674;15453828;15501038;1554744;15667203;15858218;15865431;15990874;16006130;16106378;16134940;16214338;16290146;16302824;16506782;16511248;16563834;16686544;16759856;16787097;16807956;16820676;16942027;16992238;16994616;17000110;17012249;17071654;17125255;17127057;17181151;17228881;17251017;17314045;17319692;17330962;17346964;17407288;17427958;17499996;17540563;17588751;17705204;17712059;17761422;17990881;18024029;18161740;18162396;18260615;18266323;18294854;18359629;18374572;18461940;18481843;18618712;18640037;18703501;18723489;18768466;18942852;18984734;1909891;1910042;19115843;19170619;19186056;19206230;19273840;1928091;1932029;19520834;19583303;19668749;19731956;19778001;19827837;20162361;20230836;20349499;20493921;20578724;21041929;2111324;21282642;2169869;22001224;234739;24275569;2506737;25937211;29242379;29508533;29557506;29789417;3000449;3080418;3108857;3119859;3121496;3136125;3151019;3151020;31844290;32157095;32387766;32897882;32983136;33392160;33592498;34509645;35051231;35138101;36215666;36709914;37895185;37938771;38411550;38520652;39306647;3938604;4203704;4207120;4514311;4621826;4647257;4975618;4994926;5656372;6407977;6417382;6433979;6817747;6819139;7541176;7608893;7625839;7696263;7761440;7803386;7901850;8070313;8070585;8083199;8142888;8218160;823150;8262987;8300612;8331673;8356065;8399159;8399223;8431430;8451242;8482389;8485129;8557623;8639494;8834238;8875343;8972395;8987974;9054574;9143858;9143915;9265618;9336012;9398308;9486145;9541386;9635771;9784398;9865942",
        "class_list": "",
        "function": "Carbonic anhydrase II deficiency., [RefSeq, PubMed]; Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]., [RefSeq]; Unlocking the Potential of the CA2, CA7, and ITM2C Gene Signatures for the Early Detection of Colorectal Cancer: A Comprehensive Analysis of RNA-Seq Data by Utilizing Machine Learning Algorithms. Publication Status: Online-Only, [RefSeq, PubMed]; XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures., [RefSeq, PubMed]; [1]H, [15]N and [13]C resonance assignments of the S2A and H64A double mutant of human carbonic anhydrase II., [RefSeq, PubMed]; [1]H, [15]N and[13]C resonance assignments of S2A mutant of human carbonic anhydrase II., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 57,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 13,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7G8;Q6FI12;Q96ET9",
        "ec_number_list": "4.2.1.1;4.2.1.69;5.6.1.6",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004064 arylesterase activity;GO:0004089 carbonate dehydratase activity;GO:0018820 cyanamide hydratase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045177 apical part of cell;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0038166 angiotensin-activated signaling pathway;GO:0015670 carbon dioxide transport;GO:0051453 regulation of intracellular pH;GO:0044070 regulation of monoatomic anion transport;GO:2001150 positive regulation of dipeptide transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 21.6,
        "record_id": "P00918-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6L9W6-1",
        "uniprot_id": "B4GN3_HUMAN",
        "mass": 114975.0,
        "length": 998,
        "protein_name": "Beta-1,4-N-acetylgalactosaminyltransferase 3",
        "gene_name": "B4GALNT3",
        "organism": "Human",
        "refseq_name": "beta-1,4-N-acetylgalactosaminyltransferase 3",
        "refseq_ac": "NP_775864",
        "gene_names_uniprotkb": "B4GALNT3",
        "gene_names_refseq": "B4GALNT3",
        "protein_names_uniprotkb": "Beta-1,4-N-acetylgalactosaminyltransferase 3; 2.4.1.244; B4GalNAcT3; Beta-1,4-N-acetylgalactosaminyltransferase III; Beta4GalNAc-T3; Beta4GalNAcT3; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2; NGalNAc-T2",
        "protein_names_refseq": "B4GalNAcT3; Beta4GalNAc-T3; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase; N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2; NGalNAc-T2; beta-1,4-N-acetyl-galactosaminyl transferase 3; beta-1,4-N-acetylgalactosaminyltransferase 3; beta-1,4-N-acetylgalactosaminyltransferase III; beta4GalNAcT3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283358)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;11237011;12966086;16728562;17579116;18048353;20360844;22722937;22722940;23584533;25003232;25803323;25813380;29557506;31154438;32582212;34561969;35051231;38844136",
        "class_list": "glycogene;glycosyltransferase",
        "function": "B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by OMIM, Aug 2008]., [RefSeq]; BetaGT3 and betaGT4, that are able to transfer GalNAc to GlcNAc in beta1,4-linkage display the necessary glycoprotein specificity in vivo., [RefSeq, PubMed]; Data suggest B4GALNT3 regulates cancer stemness and the invasive properties of colon cancer cells through modifying EGFR glycosylation and signaling., [RefSeq, PubMed]; Identify a new chimeric transcript generated by the fusion of WNK1 and B4GALNT3 genes, correlated with B4GALNT3 overexpression papillary thyroid carcinoma., [RefSeq, PubMed]; LacdiNAc synthase B4GALNT3 has a unique PA14 domain and suppresses N-glycan capping., [RefSeq, PubMed]; Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4., [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4., [RefSeq, PubMed]; Supra-nuclear expression of beta4GalNAc-T3 is essential for the formation of LacdiNAc on the surface mucous cells and that LacdiNAc and beta4GalNAc-T3 are novel differentiation markers of surface mucous cells in the gastric mucosa., [RefSeq, PubMed]; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa., [UniProtKB, PubMed]; Up-regulation of beta4GalNAc-T3 may play a critical role in promoting tumor malignanc, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1259,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ZNC1;Q8N7T6",
        "ec_number_list": "2.4.1.244",
        "go_molecular_function": "GO:0008376 acetylgalactosaminyltransferase activity;GO:0033842 N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 865,
        "hit_score": 3.0,
        "record_id": "Q6L9W6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q01954-1",
        "uniprot_id": "BNC1_HUMAN",
        "mass": 110972.0,
        "length": 994,
        "protein_name": "Zinc finger protein basonuclin-1",
        "gene_name": "BNC1",
        "organism": "Human",
        "refseq_name": "zinc finger protein basonuclin-1 isoform b",
        "refseq_ac": "NP_001288135",
        "gene_names_uniprotkb": "BNC1; BNC",
        "gene_names_refseq": "BNC1; BNC; BSN1; HsT19447; POF16; bn1",
        "protein_names_uniprotkb": "Zinc finger protein basonuclin-1",
        "protein_names_refseq": "basonuclin 1; zinc finger protein basonuclin-1 isoform b; zinc finger protein basonuclin-1",
        "tax_id": 9606,
        "disease": "primary ovarian insufficiency 16 (Disease Ontology:DOID:0080873)",
        "pathway": " (hsa:646)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "11237011;1332044;16891417;25645385;26992070;28832583;29242379;30010909;31222486;31767620;31844290;32157095;32387766;32897882;32938616;33981976;34087483;34148047;34644201;35051231;36198708;8034748;9099851;9223293;9687312",
        "class_list": "",
        "function": "BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Cell heterogeneity is conserved in human epicardium, regulated by BNC1 and associated with cell fate and function. Publication Status: Online-Only, [RefSeq, PubMed]; Clinicopathological significance and underlying molecular mechanism of downregulation of basonuclin 1 expression in ovarian carcinoma., [RefSeq, PubMed]; This gene encodes a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. Disruption of this gene has been implicated in premature ovarian failure as well as testicular premature aging. [provided by RefSeq, Sep 2020]., [RefSeq]; Transcriptional activator (By similarity). It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles (PubMed:8034748). Required for the maintenance of spermatogenesis (By similarity). It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade (PubMed:30010909). May also play a role in the early development of embryos (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Transcriptional activator. It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles. Required for the maintenance of spermatogenesis. It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade. May also play a role in the early development of embryos., [UniProtKB, UniProtKB]; Upregulation of Basonuclin1 Is Associated with p63-Involved Epithelial Barrier Impairment and Type-2 Helper T-cell Inflammation in Chronic Rhinosinusitis with Nasal Polyps., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15840",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000182 rDNA binding;GO:0001216 DNA-binding transcription activator activity;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0008544 epidermis development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q01954-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6QNY0-1",
        "uniprot_id": "BL1S3_HUMAN",
        "mass": 21256.0,
        "length": 202,
        "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 3",
        "gene_name": "BLOC1S3",
        "organism": "Human",
        "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 3",
        "refseq_ac": "NP_997715",
        "gene_names_uniprotkb": "BLOC1S3; BLOS3",
        "gene_names_refseq": "BLOC1S3; BLOS3; HPS8; RP",
        "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 3; BLOC-1 subunit 3",
        "protein_names_refseq": "BLOC-1 subunit 3; biogenesis of lysosome-related organelles complex 1 subunit 3; biogenesis of lysosome-related organelles complex-1, subunit 3; reduced pigmentation, mouse, homolog of",
        "tax_id": 9606,
        "disease": "Hermansky-Pudlak syndrome 8 (Disease Ontology:DOID:0060546)",
        "pathway": " (hsa:388552);  (R-HSA-432722)",
        "pathway_count": 2,
        "publication_count": 46,
        "publication_id_list": "10394364;11237011;11590181;11604418;11694590;11994746;15102850;16155256;16385460;17081983;17116749;17182842;18452278;18669648;18707149;19413330;19651622;19690332;20068231;20166139;22203680;23186163;23301498;23481700;24275569;25645385;26154972;27397612;27846572;27920218;28832583;30387913;30429286;31844290;32387766;32687635;32938616;33141586;33298915;33968037;33981976;34509645;35051231;8374173;8524399;8670264",
        "class_list": "",
        "function": "A germline mutation in BLOC1S3/reduced pigmentation causes a novel variant of Hermansky-Pudlak syndrome (HPS8)., [RefSeq, PubMed]; BLOC-2 and BLOC-3 were destabilized due to the mutation of these Hermansky-Pudlak syndrome (HPS) genes which are so far the only reported causative genes in Chinese HPS patients, [RefSeq, PubMed]; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking., [UniProtKB, PubMed, PubMed]; Novel variants in the BLOC1S3 gene in patients presenting a mild form of Hermansky-Pudlak syndrome., [RefSeq, PubMed]; This gene encodes a protein that is a component of the BLOC1 multi-subunit protein complex. This complex is necessary for the biogenesis of specialized organelles of the endosomal-lysosomal system, including platelet dense granules and melanosomes. Mutations in this gene cause Hermansky-Pudlak syndrome 8, a disease characterized by lysosomal storage defects, bleeding due to platelet storage pool deficiency, and oculocutaneous albinism. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RXB8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008320 protein transmembrane transporter activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0030133 transport vesicle;GO:1904115 axon cytoplasm;GO:0031083 BLOC-1 complex",
        "go_biological_process": "GO:0031175 neuron projection development;GO:0030168 platelet activation;GO:0060155 platelet dense granule organization;GO:0008089 anterograde axonal transport;GO:0032438 melanosome organization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q6QNY0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14523-1",
        "uniprot_id": "C2C2L_HUMAN",
        "mass": 76181.0,
        "length": 706,
        "protein_name": "Phospholipid transfer protein C2CD2L",
        "gene_name": "C2CD2L",
        "organism": "Human",
        "refseq_name": "phospholipid transfer protein C2CD2L isoform 2",
        "refseq_ac": "NP_001277403",
        "gene_names_uniprotkb": "C2CD2L; DLNB23; KIAA0285; TMEM24",
        "gene_names_refseq": "C2CD2L; DLNB23; TMEM24",
        "protein_names_uniprotkb": "Phospholipid transfer protein C2CD2L; C2 domain-containing protein 2-like; C2CD2-like; Transmembrane protein 24",
        "protein_names_refseq": "C2 domain-containing protein 2-like; phospholipid transfer protein C2CD2L isoform 2; phospholipid transfer protein C2CD2L; transmembrane protein 24",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9854)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "11237011;18669648;19690332;23186163;24012759;26992070;28209843;28657654;28832583;29242379;29557506;31154438;31844290;31848261;32157095;32357974;32938616;33298915;33479206;33592498;33912179;35051231;39158698;9179496",
        "class_list": "",
        "function": "A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts., [RefSeq, PubMed]; Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24. Publication Status: Online-Only, [RefSeq, PubMed]; In the absence of TMEM24, calcium oscillations are abolished, leading to a defect in triggered insulin release., [RefSeq, PubMed]; Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843)., [UniProtKB, PubMed]; Paper describes the tissue distribution, interaction partners and pathway where this protein functions.  This paper shows that C2CD2L (TMEM24) interacts with insulin and plays a role in Glucose stimulated insulin secretion in pancreatic islets. Also, at protein level shows enrichment for expression in pancreatic islets and brain., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86UT7;Q86V04;Q8N522;Q8TBN4;Q96G10",
        "ec_number_list": "",
        "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0008526 phosphatidylinositol transfer activity;GO:0043559 insulin binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032541 cortical endoplasmic reticulum;GO:0140268 endoplasmic reticulum-plasma membrane contact site",
        "go_biological_process": "GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "O14523-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60512-1",
        "uniprot_id": "B4GT3_HUMAN",
        "mass": 43928.0,
        "length": 393,
        "protein_name": "Beta-1,4-galactosyltransferase 3",
        "gene_name": "B4GALT3",
        "organism": "Human",
        "refseq_name": "beta-1,4-galactosyltransferase 3",
        "refseq_ac": "NP_001186802",
        "gene_names_uniprotkb": "B4GALT3",
        "gene_names_refseq": "B4GALT3; beta4Gal-T3",
        "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 3; 2.4.1.-; 2.4.1.275; 2.4.1.38; 2.4.1.90; Beta-1,4-GalTase 3; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; Beta4Gal-T3; N-acetyllactosamine synthase; Nal synthase; Neolactotriaosylceramide beta-1,4-galactosyltransferase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3; b4Gal-T3",
        "protein_names_refseq": "N-acetyllactosamine synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3; b4Gal-T3; beta-1,4-GalTase 3; beta-1,4-galactosyltransferase 3; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 3; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; epididymis secretory sperm binding protein; nal synthase; neolactotriaosylceramide beta-1,4-galactosyltransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8703);  (R-HSA-2022854);  (R-HSA-975577)",
        "pathway_count": 3,
        "publication_count": 80,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10206952;10395745;10491328;10504389;10570912;10580128;10700233;10766765;11030741;11042166;11042394;11283017;11421344;11425186;11530204;11588157;11821425;11901181;12097641;12218059;12603328;12765789;15486459;15560372;15620693;15939404;16434023;16924681;17006639;17021253;1714903;17488527;17613536;18931531;19403558;20117844;23481700;23584533;24190977;24715725;25502872;26375851;27846572;28218747;28467828;28904123;29242379;29314611;29557506;29741879;30312173;30315122;30410026;30561605;31020640;31611695;31844290;32157095;32202233;32350084;33141586;33298915;33592498;33936100;34050113;34171305;34211107;35154160;35251023;38034954;8333853;8611500;8920913;9054414;9405390;9405439;9417100;9597550",
        "class_list": "glycogene;glycosyltransferase",
        "function": "B4GALT3 promotes cell proliferation and invasion in glioblastoma., [RefSeq, PubMed]; B4GALT3, DAP3, RGS16, TMEM183A and UCK2--were significantly overexpressed in dup(1q)-positive ALLs compared with high hyperdiploid ALLs without dup(1q)., [RefSeq, PubMed]; In bladder tumor cells circUBXN7 serves as a competitive endogenous RNA of miR-1247-3p to elevate B4GALT3 expression, consequently inhibiting cell viability and invasion., [RefSeq, PubMed]; Long noncoding RNA differentiation antagonizing nonprotein coding RNA promotes the proliferation, invasion and migration of neuroblastoma cells via targeting beta-1, 4-galactosyltransferase III by sponging miR-338-3p., [RefSeq, PubMed]; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids., [UniProtKB, PubMed, PubMed]; These findings suggest that the transcription of the b4GalT3 gene is regulated by differential DNA binding of Sp3 and Sp1 in neuroblastoma and lung cancer. The increased expression of b4GalT3 in neuroblastoma may be ascribed to the enhanced expression of Sp3, which is observed for various cancers., [RefSeq, PubMed]; This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 417,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 10,
        "disease_count": 0,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DVG3;O60910;Q9BPZ4;Q9H8T2",
        "ec_number_list": "2.4.1.-;2.4.1.274;2.4.1.275;2.4.1.38;2.4.1.90;2.4.1.22",
        "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945 N-acetyllactosamine synthase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0070062 extracellular exosome;GO:0032580 Golgi cisterna membrane",
        "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006682 galactosylceramide biosynthetic process;GO:0006678 glucosylceramide metabolic process",
        "synthesized_glycan_count": 10105,
        "hit_score": 10.0,
        "record_id": "O60512-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P15291-1",
        "uniprot_id": "B4GT1_HUMAN",
        "mass": 43920.0,
        "length": 398,
        "protein_name": "Beta-1,4-galactosyltransferase 1",
        "gene_name": "B4GALT1",
        "organism": "Human",
        "refseq_name": "beta-1,4-galactosyltransferase 1 isoform 1",
        "refseq_ac": "NP_001488",
        "gene_names_uniprotkb": "B4GALT1; GGTB2",
        "gene_names_refseq": "B4GAL-T1; B4GALT1; CDG2D; CLDLFIB; GGTB2; GT1; GTB; beta4Gal-T1",
        "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 1; 2.4.1.-; 2.4.1.22; 2.4.1.275; 2.4.1.38; 2.4.1.90; Beta-1,4-GalTase 1; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; Beta4Gal-T1; Lactose synthase A protein; N-acetyllactosamine synthase; Nal synthase; Neolactotriaosylceramide beta-1,4-galactosyltransferase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1; b4Gal-T1",
        "protein_names_refseq": "N-acetyllactosamine synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1; beta-1,4-GalTase 1; beta-1,4-galactosyltransferase 1 isoform 1; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; glycoprotein-4-beta-galactosyltransferase 2; lactose synthase A protein; nal synthase; neolactotriaosylceramide beta-1,4-galactosyltransferase",
        "tax_id": 9606,
        "disease": "congenital disorder of glycosylation type IId (Disease Ontology:DOID:0070256); endocrine system disease (Disease Ontology:DOID:28); IgA glomerulonephritis (Disease Ontology:DOID:2986); congenital disorder of glycosylation (Disease Ontology:DOID:5212); combined low LDL and fibrinogen (MONDO:MONDO:0957260)",
        "pathway": " (hsa:2683);  (R-HSA-1912420);  (R-HSA-2022854);  (R-HSA-2534343);  (R-HSA-3656244);  (R-HSA-4793953);  (R-HSA-5653890);  (R-HSA-6798695);  (R-HSA-975577)",
        "pathway_count": 9,
        "publication_count": 182,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10075724;10206952;10366590;10395745;10459009;10491328;10504389;10545110;10570912;10580128;10669757;10700233;10759149;10766765;10935626;10935637;11030741;11042166;11042394;11135303;11237011;11283017;11419947;11421344;11425186;11530204;11588157;11707585;11821425;11901181;11947697;12049766;12097641;12218059;12603328;12765789;1295745;1384956;15486459;15560372;15620693;15939404;16157350;16434023;16497331;16924681;17006639;17021253;1714903;17488527;1764995;18512783;18931531;1903938;19106107;19403558;19701457;20068231;20117844;20170518;20197277;20364096;20378551;21081667;21097675;2120039;2124683;23481700;23584533;23650620;23783831;24715725;25418920;25502872;25548167;25576301;25813380;26154972;26375851;26811146;26929215;26992070;27090790;27452731;27846572;27872474;28063628;28228285;28832583;28904123;29133956;29242379;29314611;29317506;29393594;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30429286;30459171;30484775;30626607;30653653;30833945;3091013;3094506;31217245;3144273;31611695;31844290;31848261;31937595;31998317;32157095;32157688;32161166;32350084;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33936100;33968037;34087483;34211107;34357683;34433824;34509645;34561969;34725712;34846842;34855475;34932366;35051231;35154160;35251023;35580925;36215666;36241641;36280670;36284347;37198983;37303063;37328064;37632720;38034954;38321209;38665916;39531497;7540104;7579794;7744867;7918097;806951;8195297;8293978;8333853;8611500;8681805;8692836;8920913;9054414;9187150;9207795;9244302;9405439;9417100;9597550;9653148;9727485",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Analysis of the Interaction of UBE2Q1 with B4GALT1 and P53: Experimental and Molecular Modeling Study., [RefSeq, PubMed]; B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Galactosyltransferase acting in the Golgi stacks. Catalyzes the transfer of galactose (Gal) from UDP-alpha-D-galactose in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type N-linked glycans (PubMed:16157350, PubMed:27872474, PubMed:29133956, PubMed:36280670, PubMed:37632720, PubMed:38321209). Adds one Gal residue to both GlcNAc beta(1->2)-linked to the alpha(1->3) and alpha(1->6) mannose antennae of complex-type N-glycans, enabling the formation of mono- and di-galactosylated glycoforms. Galactosylates complex-type N-glycans attached on the fragment crystallizable (Fc) of immunoglobulin-gamma isotypes (IgGs), a prerequisite for antibody glycan sialylation and related anti-inflammatory effector functions (PubMed:27872474, PubMed:29133956, PubMed:36280670, PubMed:37632720). Can also transfer a Gal residue to free GlcNAc to form N-acetyllactosamine (PubMed:16157350). With LALBA/alpha-lactalbumin forms the lactose synthase complex responsible for production of large amounts of lactose in the lactating mammary gland. Interaction with LALBA alters the sugar substrate specificity of the catalytic domain, enabling high affinity binding of glucose and its transformation to lactose (PubMed:16157350)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen., [RefSeq, PubMed]; In-Depth Mass Spectrometry Analysis Reveals the Plasma Proteomic and N-Glycoproteomic Impact of an Amish-Enriched Cardioprotective Variant in B4GALT1., [RefSeq, PubMed]; The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, like those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. Acts as a sperm receptor for ZP3 O-linked glycans on the zona pellucida leading to activation of G protein signaling and acrosome reaction., [UniProtKB, UniProtKB]; The secreted form is proficient in galactosyltransferase activity and could be involved in glycan remodeling in biological fluids., [UniProtKB, UniProtKB]; This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 10,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 10,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 10,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 2,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 464,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 5,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R710;D3DRL2;Q12909;Q12910;Q12911;Q14456;Q14509;Q14523",
        "ec_number_list": "3.2.1.25;2.4.1.-;2.4.1.274;3.4.24.-;2.4.1.275;2.4.1.38;2.4.1.90;2.4.1.22;3.5.1.92;3.6.5.2;3.4.24.11;3.1.3.48;3.2.1.20;2.5.1.18;3.4.11.2;3.1.3.5;3.1.3.2;3.4.16.2;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;3.4.23.-;7.6.2.-;2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;7.6.2.1",
        "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006487 protein N-linked glycosylation;GO:0009312 oligosaccharide biosynthetic process;GO:0005989 lactose biosynthetic process;GO:0061755 positive regulation of circulating fibrinogen levels",
        "synthesized_glycan_count": 10444,
        "hit_score": 19.6,
        "record_id": "P15291-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P22004-1",
        "uniprot_id": "BMP6_HUMAN",
        "mass": 57226.0,
        "length": 513,
        "protein_name": "Bone morphogenetic protein 6",
        "gene_name": "BMP6",
        "organism": "Human",
        "refseq_name": "bone morphogenetic protein 6 preproprotein",
        "refseq_ac": "NP_001709",
        "gene_names_uniprotkb": "BMP6; VGR",
        "gene_names_refseq": "BMP6; IO; VGR1; VGR",
        "protein_names_uniprotkb": "Bone morphogenetic protein 6; BMP-6; VG-1-R; VG-1-related protein; VGR-1",
        "protein_names_refseq": "VG-1-R; VG-1-related protein; bone morphogenetic protein 6 preproprotein; vegetal related growth factor (TGFB-related)",
        "tax_id": 9606,
        "disease": "colitis (Disease Ontology:DOID:0060180); prostate cancer (Disease Ontology:DOID:10283); Marfan syndrome (Disease Ontology:DOID:14323); breast cancer (Disease Ontology:DOID:1612); brain ischemia (Disease Ontology:DOID:2316); anemia (Disease Ontology:DOID:2355); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal cell carcinoma (Disease Ontology:DOID:4450); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970); iron overload, susceptibility to (MONDO:MONDO:0859316)",
        "pathway": " (hsa:654)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;16959974;17924656;18070108;2263636;23584533;26582087;27590690;27591421;28335084;30097509;30484775;31019025;31640930;31800957;32350084;32464486;32488085;33021694;34037557;35251023;36153321;37795636;37930517;38323352",
        "class_list": "",
        "function": "BMP6 and VDR gene polymorphisms are associated with osteonecrosis in a sickle cell anaemia cohort., [RefSeq, PubMed]; BMP6 participates in the pathogenesis of adolescent idiopathic scoliosis by regulating osteopenia., [RefSeq, PubMed]; Bone morphogenetic protein 6 induces downregulation of pentraxin 3 expression in human granulosa lutein cells in women with polycystic ovary syndrome., [RefSeq, PubMed]; Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (PubMed:31019025). Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV (PubMed:26582087). Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3 (PubMed:30097509, PubMed:31800957). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B (PubMed:18070108). In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (PubMed:33021694)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 11,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TCP3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0031982 vesicle;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "P22004-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P30411-1",
        "uniprot_id": "BKRB2_HUMAN",
        "mass": 44461.0,
        "length": 391,
        "protein_name": "B2 bradykinin receptor",
        "gene_name": "BDKRB2",
        "organism": "Human",
        "refseq_name": "B2 bradykinin receptor",
        "refseq_ac": "NP_000614",
        "gene_names_uniprotkb": "BDKRB2; BKR2",
        "gene_names_refseq": "B2R; BDKRB2; BK-2; BK2; BKR2; BRB2",
        "protein_names_uniprotkb": "B2 bradykinin receptor; B2R; BK-2 receptor",
        "protein_names_refseq": "B2 bradykinin receptor; BK-2 receptor",
        "tax_id": 9606,
        "disease": "pleurisy (Disease Ontology:DOID:10247); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); epilepsy (Disease Ontology:DOID:1826); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); lung disease (Disease Ontology:DOID:850)",
        "pathway": " (hsa:624);  (R-HSA-375276);  (R-HSA-416476);  (R-HSA-418594)",
        "pathway_count": 4,
        "publication_count": 158,
        "publication_id_list": "10079109;10085087;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10899166;11007482;11015615;11322507;11385580;11457843;11517230;11562423;11683476;11742120;11753430;11773063;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1329734;1337145;1346068;14463577;14550283;14573733;15139756;15539556;1567413;15947423;15951850;16182515;16226010;16268778;16339447;1655761;16634148;16754659;16923326;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18515384;18577758;18672896;18936096;1905813;23446738;23690594;24906252;2534964;25576301;2649896;26992070;2748346;27496565;2834384;2841328;28834231;29557506;29789417;30779550;30833945;3086311;31154438;31844290;3202875;32387766;32938616;33537174;33592498;3366244;34087483;34171305;35038454;35051231;35132089;3525564;36010968;36075965;36142237;36215666;37217939;37703419;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7779090;7797512;7835885;7905839;7916737;7937899;8015379;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8394991;8395824;8406495;8440682;8463333;8503909;8615752;8652530;8664309;8666380;8702752;873923;8823230;9171878;9305846;9521323;9530155;9593744;9607765;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors., [RefSeq, PubMed]; Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons., [RefSeq, PubMed]; Cryo-EM structures of human bradykinin receptor-Gq proteins complexes. Publication Status: Online-Only, [RefSeq, PubMed]; Function and structure of bradykinin receptor 2 for drug discovery. Review article, [RefSeq, PubMed]; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB, PubMed, PubMed]; The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 25,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 13,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0002020 protease binding;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0046982 protein heterodimerization activity;GO:0031702 type 1 angiotensin receptor binding;GO:0004947 bradykinin receptor activity",
        "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 16.1,
        "record_id": "P30411-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P32247-1",
        "uniprot_id": "BRS3_HUMAN",
        "mass": 44411.0,
        "length": 399,
        "protein_name": "Bombesin receptor subtype-3",
        "gene_name": "BRS3",
        "organism": "Human",
        "refseq_name": "bombesin receptor subtype-3",
        "refseq_ac": "NP_001718",
        "gene_names_uniprotkb": "BRS3",
        "gene_names_refseq": "BB3R; BB3; BBR3; BRS3",
        "protein_names_uniprotkb": "Bombesin receptor subtype-3; BRS-3",
        "protein_names_refseq": "BRS-3; G-protein coupled receptor; bombesin like receptor 3; bombesin receptor subtype-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:680);  (R-HSA-375276);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 126,
        "publication_id_list": "10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10899166;11015615;11322507;11385580;11457843;11562423;11683476;11742120;11753430;11773063;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15539556;1567413;15947423;15951850;16182515;16268778;16339447;1655761;16754659;16923326;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18515384;18577758;18936096;1905813;21857995;23446738;23690594;24906252;26020940;2649896;27496565;2841328;29401613;29402494;29410320;3086311;3202875;3366244;34087483;35032194;35051231;3525564;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8035319;8062389;8063797;8131855;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8440682;8463333;8503909;8615752;8664309;8666380;8702752;873923;8823230;9171878;9305846;9521323;9530155;9593744;9607765;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "Agonist-induced extracellular vesicles contribute to the transfer of functional bombesin receptor-subtype 3 to recipient cells. Publication Status: Online-Only, [RefSeq, PubMed]; BRS-3 and EP3 interact to potentiate PGE2 signaling. This potentiating effect is receptor specific, and it occurs only when BRS-3 is paired to EP3., [RefSeq, PubMed]; BRS-3 protein levels were decreased in diabetic rat and in obese and diabetic human fat pieces., [RefSeq, PubMed]; Mammalian homologue of CCHa2-R, Bombesin receptor subtype-3 (Brs3), is an orphan receptor that is expressed in the islet beta-cells Erratum:[PLoS Genet. 2015 Sep 22;11(9):e1005481. doi: 10.1371/journal.pgen.1005481. PMID: 26394035] Publication Status: Online-Only, [RefSeq, PubMed]; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB]; The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]., [RefSeq]; These results suggest that human BRS-3, similar to GRPR/NMBR, is frequently ectopically-expressed by lung-cancer cells in which, it is functional, affecting cell signaling/growth., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0004946 bombesin receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0008217 regulation of blood pressure;GO:0006006 glucose metabolic process;GO:0008343 adult feeding behavior",
        "synthesized_glycan_count": 0,
        "hit_score": 12.7,
        "record_id": "P32247-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P35219-1",
        "uniprot_id": "CAH8_HUMAN",
        "mass": 32973.0,
        "length": 290,
        "protein_name": "Carbonic anhydrase-related protein",
        "gene_name": "CA8",
        "organism": "Human",
        "refseq_name": "carbonic anhydrase-related protein isoform a",
        "refseq_ac": "NP_001308766",
        "gene_names_uniprotkb": "CA8; CALS",
        "gene_names_refseq": "CA-RP; CA-VIII; CA8; CALS; CAMRQ3; CARP; SCAR34",
        "protein_names_uniprotkb": "Carbonic anhydrase-related protein; CA-VIII; CARP; Carbonic anhydrase VIII",
        "protein_names_refseq": "CA-related protein; carbonate dehydratase; carbonic anhydrase VIII; carbonic anhydrase-like sequence; carbonic anhydrase-related protein isoform a; carbonic anhydrase-related protein",
        "tax_id": 9606,
        "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); autosomal recessive spinocerebellar ataxia 34 (Disease Ontology:DOID:0070558)",
        "pathway": " (hsa:767)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "10671200;19172221;19360879;19461874;19651622;23301498;25645385;26711783;27600516;28832583;29242379;32157095;32488085;32897882;32938616;34171305;35051231;35488942;35494241;35901081;37938771;38571370;39302247;40307207;8482548",
        "class_list": "",
        "function": "Altered glucose metabolism and its association with carbonic anhydrase 8 in Machado-Joseph Disease., [RefSeq, PubMed]; Carbonic anhydrase XII as biomarker and therapeutic target in ovarian carcinomas. Publication Status: Online-Only, [RefSeq, PubMed]; Consanguineous Iraqi family in which affected siblings had mild mental retardation and congenital ataxia characterized by quadrupedal gait. The mutation S100P is associated with proteasome-mediated degradation, and presumably represents a null mutation., [RefSeq, PubMed]; Does not have a carbonic anhydrase catalytic activity., [UniProtKB]; Effects of down-regulated carbonic anhydrase 8 on cell survival and glucose metabolism in human colorectal cancer cell lines., [RefSeq, PubMed]; The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]., [RefSeq]; The results suggest that the variations of CA8 and CA10 loci may be important determinants of osteoporosis in Japanese women. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; We observed increased expression of CA8 in more aggressive types of human osteosarcoma (OS) cells and found that CA8 expression is correlated with disease stages, such that more intense expression occurs in the disease late stage, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K0A5;B3KQZ7;Q32MY2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "P35219-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51813-1",
        "uniprot_id": "BMX_HUMAN",
        "mass": 78011.0,
        "length": 675,
        "protein_name": "Cytoplasmic tyrosine-protein kinase BMX",
        "gene_name": "BMX",
        "organism": "Human",
        "refseq_name": "cytoplasmic tyrosine-protein kinase BMX isoform 2",
        "refseq_ac": "NP_001307795",
        "gene_names_uniprotkb": "BMX",
        "gene_names_refseq": "BMX; ETK; PSCTK2; PSCTK3",
        "protein_names_uniprotkb": "Cytoplasmic tyrosine-protein kinase BMX; 2.7.10.2; Bone marrow tyrosine kinase gene in chromosome X protein; ETK; Epithelial and endothelial tyrosine kinase; NTK38",
        "protein_names_refseq": "BTK-like on X chromosome; Etk/Bmx cytosolic tyrosine kinase; NTK38 tyrosine kinase; bone marrow tyrosine kinase gene in chromosome X protein; cytoplasmic tyrosine-protein kinase BMX isoform 2; cytoplasmic tyrosine-protein kinase BMX; epithelial and endothelial tyrosine kinase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:660);  (R-HSA-111465);  (R-HSA-1660499)",
        "pathway_count": 3,
        "publication_count": 119,
        "publication_id_list": "10194451;10200466;10224048;10453075;10490026;10555148;10559940;10593988;10688651;10753883;10805725;10822173;11001876;11084340;11106668;11114746;11278797;11279162;11302699;11313965;11331870;11340625;11349134;11463840;11604140;11676921;11733541;11741893;11751885;11877430;11923287;12101241;12107159;12118066;12324459;12370298;12422219;12536145;12573241;12646134;12668660;12808147;12832404;12847086;14516276;14617813;14660569;15080793;15107860;15135396;15464023;15716355;15788485;15797027;15840652;16123041;16154996;16399794;16476736;16522682;16914545;16979564;16983089;17008356;17245604;17297457;17344846;17624943;17651088;18093523;18292575;18753295;19038970;19896968;20004564;20534812;21204784;21408190;22037487;22647598;23519112;23758345;24556848;25495341;26992070;29493099;30429286;34171305;35051231;36010968;36647826;39133652;7608176;7624799;7970727;8681945;8723348;8769125;8976194;9094719;9113989;9211928;9252332;9286278;9295334;9325343;9367159;9428629;9431985;9514948;9516481;9520419;9524259;9593664;9660759;9660833;9811831;9830063;9973322",
        "class_list": "",
        "function": "BMX controls 3betaHSD1 and sex steroid biosynthesis in cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G protein-coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 15,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NIH9;O60564;Q12871",
        "ec_number_list": "2.7.12.2;2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.1.40;2.7.1.32;2.7.1.82;2.7.10.4;3.4.22.56;2.7.11.13;2.7.11.23",
        "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032587 ruffle membrane",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.0,
        "record_id": "P51813-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P60827-1",
        "uniprot_id": "C1QT8_HUMAN",
        "mass": 27685.0,
        "length": 252,
        "protein_name": "Complement C1q tumor necrosis factor-related protein 8",
        "gene_name": "C1QTNF8",
        "organism": "Human",
        "refseq_name": "complement C1q tumor necrosis factor-related protein 8 precursor",
        "refseq_ac": "NP_997302",
        "gene_names_uniprotkb": "C1QTNF8; PRO19648",
        "gene_names_refseq": "C1QTNF8; CTRP8; UNQ5829",
        "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 8; C1q/TNF-related protein 8; CTRP8",
        "protein_names_refseq": "C1q and tumor necrosis factor related protein 8; C1q/TNF-related protein 8; complement C1q tumor necrosis factor-related protein 8 precursor; complement C1q tumor necrosis factor-related protein 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:390664)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "12975309;19666007;24014093;29949238;32387766;36921737;38253038",
        "class_list": "",
        "function": "Direct interaction of human CTRP8 with RXFP1, [RefSeq, PubMed]; Human C1q Tumor Necrosis Factor 8 (CTRP8) defines a novel tryptase+ mast cell subpopulation in the prostate cancer microenvironment., [RefSeq, PubMed]; May play a role as ligand of RXFP1., [UniProtKB, PubMed]; This study demonstrates a novel role for CTRP8 in protecting human glioblastoma cells against the DNA alkylating damage of temozolomide, the standard chemotherapy drug used to treat glioblastoma. This DNA protective role of CTRP8 required a functional RXFP1-STAT3 signaling cascade in glioblastoma cells. CTRP8-RXFP1-STAT3 axis is an emerging new drug target for improved treatment of human glioblastoma., [RefSeq, PubMed]; Two novel human C1q/TNF family members, designated as CTRP8 and CTRP9B were described., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7U178",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:2000147 positive regulation of cell motility",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "P60827-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P62324-1",
        "uniprot_id": "BTG1_HUMAN",
        "mass": 19209.0,
        "length": 171,
        "protein_name": "Protein BTG1",
        "gene_name": "BTG1",
        "organism": "Human",
        "refseq_name": "protein BTG1",
        "refseq_ac": "NP_001722",
        "gene_names_uniprotkb": "BTG1",
        "gene_names_refseq": "APRO2; BTG1",
        "protein_names_uniprotkb": "Protein BTG1; B-cell translocation gene 1 protein",
        "protein_names_refseq": "B-cell translocation gene 1 protein; B-cell translocation gene 1, anti-proliferative; protein BTG1",
        "tax_id": 9606,
        "disease": "protein-energy malnutrition (Disease Ontology:DOID:11801); acute myeloid leukemia (Disease Ontology:DOID:9119)",
        "pathway": " (hsa:694);  (R-HSA-9617828)",
        "pathway_count": 2,
        "publication_count": 84,
        "publication_id_list": "11136725;11782012;11884591;11964479;1373383;15084259;15458387;1546328;16034111;18444242;2069907;22424782;23186163;23481700;23580232;23918930;24047697;24714562;24715725;25017022;25418920;25576301;25645385;25843800;25880248;26154972;26728094;26811146;26929215;26992070;27846572;28063628;28228285;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29786170;30315122;30410026;30524438;30779550;31217245;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33392160;33592498;33691108;33717175;33936100;33968037;33981976;34087483;34171305;34211107;34509645;34932366;35051231;35318648;35561310;35580925;35880434;36010968;36215666;36241641;36284347;36375119;36656933;37938771;9712883;9820826",
        "class_list": "",
        "function": "Anti-proliferative protein., [UniProtKB, PubMed]; BTG1 inactivation drives lymphomagenesis and promotes lymphoma dissemination through activation of BCAR1., [RefSeq, PubMed]; BTG1 mutation yields supercompetitive B cells primed for malignant transformation., [RefSeq, PubMed]; Emerging role of anti-proliferative protein BTG1 and BTG2. Review article, [RefSeq, PubMed]; This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "prognostic",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P31607",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0019900 kinase binding;GO:0003712 transcription coregulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0016477 cell migration;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "P62324-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q075Z2-1",
        "uniprot_id": "BSPH1_HUMAN",
        "mass": 15693.0,
        "length": 132,
        "protein_name": "Binder of sperm protein homolog 1",
        "gene_name": "BSPH1",
        "organism": "Human",
        "refseq_name": "binder of sperm protein homolog 1 precursor",
        "refseq_ac": "NP_001121798",
        "gene_names_uniprotkb": "BSPH1",
        "gene_names_refseq": "BSP1; BSPH1; ELSPBP2",
        "protein_names_uniprotkb": "Binder of sperm protein homolog 1; Bovine seminal plasma protein homolog 1; Bovine seminal plasma protein-like 1",
        "protein_names_refseq": "binder of sperm 1; binder of sperm protein homolog 1 precursor; bovine seminal plasma protein homolog 1; bovine seminal plasma protein-like 1; epididymal sperm binding protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100131137)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "17085770;19091820;24435510",
        "class_list": "",
        "function": "BSPH1 accumulates in inclusion bodies when expressed with an N-terminal hexahistidine tag in BL21 (DE3) Escherichia coli cells, and recombinant protein bound phosphatidylcholine liposomes, low-density lipoproteins and human sperm., [RefSeq, PubMed]; Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B., [UniProtKB, UniProtKB]; Results show that the human epididymal BSPH1 shares many biochemical and functional characteristics with BSP proteins secreted by seminal vesicles of ungulates, and behaves similarly to its murine epididymal orthologue BSPH1., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NIZ5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008201 heparin binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface",
        "go_biological_process": "GO:0007338 single fertilization;GO:0048240 sperm capacitation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q075Z2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q12982-1",
        "uniprot_id": "BNIP2_HUMAN",
        "mass": 36018.0,
        "length": 314,
        "protein_name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2",
        "gene_name": "BNIP2",
        "organism": "Human",
        "refseq_name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 2",
        "refseq_ac": "NP_001307604",
        "gene_names_uniprotkb": "BNIP2; NIP2",
        "gene_names_refseq": "BNIP-2; BNIP2; NIP2",
        "protein_names_uniprotkb": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2",
        "protein_names_refseq": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 2; BCL2/adenovirus E1B 19 kDa protein-interacting protein 2; BCL2/adenovirus E1B 19kDa interacting protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:663);  (R-HSA-525793)",
        "pathway_count": 2,
        "publication_count": 78,
        "publication_id_list": "10330143;10601328;10805738;11237011;11782431;12634428;18088087;18669648;18691976;19564926;19690332;20160094;21406692;23186163;23481700;24275569;24714562;24715725;25418920;25472445;25502872;25576301;25880248;25892735;26375851;26728094;26992070;27600516;27869121;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632711;29769354;29786170;30410026;31217245;31844290;32157095;32357974;32387766;32502341;32789168;32897882;32938616;32983136;33298915;33633747;33691108;33717175;33912179;33936100;33981976;34087483;34171305;34509645;34932366;35051231;35154160;35580925;35975420;36284347;7954800;9069290;9418854;9786951;9858528;9988769",
        "class_list": "",
        "function": "BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation., [RefSeq, PubMed]; BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine., [RefSeq, PubMed]; BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation. Publication Status: Online-Only, [RefSeq, PubMed]; Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins., [UniProtKB]; This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DS94",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043231 intracellular membrane-bounded organelle;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0090649 response to oxygen-glucose deprivation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.1,
        "record_id": "Q12982-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14692-1",
        "uniprot_id": "BMS1_HUMAN",
        "mass": 145807.0,
        "length": 1282,
        "protein_name": "Ribosome biogenesis protein BMS1 homolog",
        "gene_name": "BMS1",
        "organism": "Human",
        "refseq_name": "ribosome biogenesis protein BMS1 homolog",
        "refseq_ac": "NP_055568",
        "gene_names_uniprotkb": "BMS1; BMS1L; KIAA0187",
        "gene_names_refseq": "ACC; BMS1L; BMS1",
        "protein_names_uniprotkb": "Ribosome biogenesis protein BMS1 homolog; 3.6.5.-; Ribosome assembly protein BMS1 homolog",
        "protein_names_refseq": "BMS1 homolog, ribosome assembly protein; BMS1-like, ribosome assembly protein; ribosome assembly protein BMS1 homolog; ribosome biogenesis protein BMS1 homolog",
        "tax_id": 9606,
        "disease": "nonsyndromic aplasia cutis congenita (Disease Ontology:DOID:0080661)",
        "pathway": " (hsa:9790);  (R-HSA-6790901);  (R-HSA-6791226)",
        "pathway_count": 3,
        "publication_count": 169,
        "publication_id_list": "10606270;11081632;11565749;11779832;11922599;11935223;11978965;12068309;12150911;12417735;15199136;16037817;16043514;16381836;16738141;16782898;17081983;17189298;17353269;17412707;17636026;18065403;18438418;18452278;18669648;19007248;19033376;19106111;19204726;19332556;19413330;19463982;19564402;19651622;19664995;19691289;19801658;20038530;20047967;20056613;20068231;20531386;20798176;20805244;20819938;21036871;21063389;21097556;21406692;22072790;22190735;22195017;22424782;22544926;22645359;22916032;23186163;23391857;23439679;23481700;23482395;23785305;2388630;24086612;24366607;24397554;24424021;24550520;25114211;25218447;25411247;25418920;25525153;25576301;25645385;25653167;25755297;25802875;25851604;25880248;25892735;25969445;26085946;26154972;26196125;26237581;26375851;26811146;26929215;26992070;27084949;27474224;27846572;27920218;28063628;28218747;28228285;28832583;28834231;28855257;28904123;29242379;29331515;29393594;29437277;29493099;29557506;29632046;29769354;29786170;30315122;30379171;30429286;30524438;30622330;30779550;30833945;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32522876;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34509645;34516797;34561969;34725712;34932366;35051231;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37938771;39531497;40596516;9211966;9482744;9512526",
        "class_list": "",
        "function": "Analysis of KIAA0187 paralogs show that exons 14-23 were formed through satellite-associated pericentromeric-directed duplication, whereas paralogs of exons 1-9 evolved via chromosome-specific satellite-independent duplications., [RefSeq, PubMed]; Describes the distinct functions of yeast Bms1p and Tsr1p in ribosome biogenesis., [RefSeq, PubMed]; GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus., [UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene likely encodes a ribosome assembly protein. A similar protein in yeast functions in 35S-rRNA processing, which includes a series of cleavage steps critical for formation of 40S ribosomes. Related pseudogenes exist on chromosomes 2, 9, 10, 15, 16, and 22.[provided by RefSeq, Mar 2009]., [RefSeq]; We also observe evidence for an excess burden of rare, predicted loss-of-function variation in PXDNL and BMS1- two genes relevant to the broader laterality phenotype. These findings highlight potential new genes in the development of laterality defects, and suggest extensive locus heterogeneity and complex genetic models in this class of birth defects., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5QPT5;Q86XJ9",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;2.1.1.-;3.6.1.-;3.6.4.13;3.6.5.4;3.1.13.-;2.7.11.1;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0005525 GTP binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome;GO:0030686 90S preribosome;GO:0032040 small-subunit processome",
        "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA",
        "synthesized_glycan_count": 0,
        "hit_score": 17.3,
        "record_id": "Q14692-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16790-1",
        "uniprot_id": "CAH9_HUMAN",
        "mass": 49698.0,
        "length": 459,
        "protein_name": "Carbonic anhydrase 9",
        "gene_name": "CA9",
        "organism": "Human",
        "refseq_name": "carbonic anhydrase 9 precursor",
        "refseq_ac": "NP_001207",
        "gene_names_uniprotkb": "CA9; G250; MN",
        "gene_names_refseq": "CA9; CAIX; MN",
        "protein_names_uniprotkb": "Carbonic anhydrase 9; 4.2.1.1; CA-IX; CAIX; Carbonate dehydratase IX; Carbonic anhydrase IX; Membrane antigen MN; P54/58N; RCC-associated antigen G250; Renal cell carcinoma-associated antigen G250; pMW1",
        "protein_names_refseq": "CA-IX; P54/58N; RCC-associated antigen G250; RCC-associated protein G250; carbonate dehydratase IX; carbonic anhydrase 9 precursor; carbonic anhydrase IX; carbonic dehydratase; membrane antigen MN; pMW1; renal cell carcinoma-associated antigen G250",
        "tax_id": 9606,
        "disease": "endometrial hyperplasia (Disease Ontology:DOID:0080365); urinary bladder cancer (Disease Ontology:DOID:11054); hepatitis B (Disease Ontology:DOID:2043); transitional cell carcinoma (Disease Ontology:DOID:2671); breast carcinoma (Disease Ontology:DOID:3459); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:768);  (R-HSA-1234158);  (R-HSA-1475029)",
        "pathway_count": 3,
        "publication_count": 109,
        "publication_id_list": "10.1038/emboj.2013.79;10202154;10409679;10709109;11063749;11121027;11156414;11676494;11959977;11959990;120192;1312272;14611844;14668441;15184875;15340161;15501038;1554744;16006130;16302824;16310354;17228881;17314045;17427958;17499996;17705204;17761422;17804822;18041760;18162396;18187047;18294854;18669648;18703501;18767875;19186056;19206230;19788888;19805286;20224781;20349499;20493921;20578724;2111324;21282642;21479871;2169869;22001224;22037869;22645359;234739;23481700;23584533;24613356;25683712;26160453;26492414;27622074;28510447;29242379;29393594;29557506;30459171;3080418;31213507;31349673;31844290;31998317;32161166;32938616;33198416;33228233;33592498;33968037;34211107;34405274;35051231;37622732;37681672;38177154;38627429;38766857;38839363;4994926;6407977;6433979;6819139;7539918;7625839;7836384;8083199;8084592;8356065;8387214;8399223;8486430;8663540;8756616;8917528;9000051;9027736;9054574;9079689;9336012;9632793;9635771;9784398;9822602;9840812",
        "class_list": "",
        "function": "Aerobic vaginitis is associated with carbonic anhydrase IX in cervical intraepithelial neoplasia. Publication Status: Online-Only, [RefSeq, PubMed]; Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]., [RefSeq]; Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Epigenetic Regulation of Carbonic Anhydrase 9 Expression by Nitric Oxide in Human Small Airway Epithelial Cells., [RefSeq, PubMed]; LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma. Erratum:[Cell Death Dis. 2025 Feb 26;16(1):132. doi: 10.1038/s41419-025-07371-z. PMID: 40011489] Publication Status: Online-Only, [RefSeq, PubMed]; Spatial transcriptomic analysis of tumour with high and low CAIX expression in TNBC tissue samples using GeoMxtrade mark RNA assay., [RefSeq, PubMed]; Unlocking the paracrine crosstalk: adipocyte-derived factors affect carbonic anhydrase IX expression in colon and breast cancer cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 9,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T4R1",
        "ec_number_list": "4.2.1.1;4.2.1.69;2.3.1.48;2.3.1.-",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity;GO:0140677 molecular function activator activity",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0031528 microvillus membrane",
        "go_biological_process": "GO:0001666 response to hypoxia;GO:0009410 response to xenobiotic stimulus;GO:0033574 response to testosterone",
        "synthesized_glycan_count": 0,
        "hit_score": 11.8,
        "record_id": "Q16790-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q53TS8-4",
        "uniprot_id": "CTSRT_HUMAN",
        "mass": 209056.0,
        "length": 1820,
        "protein_name": "Cation channel sperm-associated targeting subunit tau",
        "gene_name": "CATSPERT",
        "organism": "Human",
        "refseq_name": "cation channel sperm-associated targeting subunit tau isoform 4",
        "refseq_ac": "NP_001161688",
        "gene_names_uniprotkb": "CATSPERT; ALS2CR11; C2CD6",
        "gene_names_refseq": "ALS2CR11; C2CD6; CATSPERT; SPGF68",
        "protein_names_uniprotkb": "Cation channel sperm-associated targeting subunit tau; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein; C2 calcium-dependent domain-containing protein 6; CatSper-tau; Catsper channel auxiliary subunit tau",
        "protein_names_refseq": "C2 calcium dependent domain containing 6; C2 calcium-dependent domain-containing protein 6; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein; amyotrophic lateral sclerosis 2 chromosome region candidate 11; catSper-tau; cation channel sperm-associated targeting subunit tau isoform 4; cation channel sperm-associated targeting subunit tau; testicular tissue protein Li 16",
        "tax_id": 9606,
        "disease": "spermatogenic failure 68 (Disease Ontology:DOID:0070567)",
        "pathway": " (hsa:151254)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "16959974;30379171;31985809;34998468",
        "class_list": "",
        "function": "An autosomal recessive form of juvenile amyotrophic lateral sclerosis was originally mapped to a region of chromosome 2 that includes this gene. The encoded protein contains a calcium-dependent membrane targeting C2 domain. This domain is often found in proteins that are involved in membrane trafficking and signal transduction. [provided by RefSeq, Jun 2016]., [RefSeq]; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CatSper complex targeting and trafficking into the quadrilinear nanodomains. Targets the preassembled CatSper complexes to elongating flagella, where it links the channel-carrying vesicles and motor proteins., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 53,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9IZH7;E9PGG4;Q8NCN6;Q96LN4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0036128 CatSper complex;GO:0097228 sperm principal piece",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation;GO:0098876 vesicle-mediated transport to the plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q53TS8-4",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5H9J7-1",
        "uniprot_id": "BEX5_HUMAN",
        "mass": 12602.0,
        "length": 111,
        "protein_name": "Protein BEX5",
        "gene_name": "BEX5",
        "organism": "Human",
        "refseq_name": "protein BEX5",
        "refseq_ac": "NP_001012996",
        "gene_names_uniprotkb": "BEX5; NADE2; NGFRAP1L1",
        "gene_names_refseq": "BEX5; NGFRAP1L1",
        "protein_names_uniprotkb": "Protein BEX5; Brain-expressed X-linked protein 5; NGFRAP1-like protein 1; Nerve growth factor receptor-associated protein 2",
        "protein_names_refseq": "BEX family member 5; NGFRAP1-like 1; NGFRAP1-like protein 1; brain-expressed X-linked protein 5; nerve growth factor receptor-associated protein 2; protein BEX5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:340542)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "15861462;15958283;22645359;29786170;32387766;33592498;34509645;37938771",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q569J0;Q56A74",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q5H9J7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5VVC0-1",
        "uniprot_id": "SPO16_HUMAN",
        "mass": 20418.0,
        "length": 180,
        "protein_name": "Protein SPO16 homolog",
        "gene_name": "C1orf146; SPO16",
        "organism": "Human",
        "refseq_name": "protein SPO16 homolog",
        "refseq_ac": "NP_001012425",
        "gene_names_uniprotkb": "C1orf146; SPO16; C1orf146; SCRE",
        "gene_names_refseq": "C1orf146; SCRE; SPO16",
        "protein_names_uniprotkb": "Protein SPO16 homolog; Synaptonemal complex reinforcing element",
        "protein_names_refseq": "protein SPO16 homolog; synaptonemal complex reinforcing element; uncharacterized protein C1orf146",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:388649)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;30379171;35051231;37217939;37270785",
        "class_list": "",
        "function": "Pathogenic bi-allelic variants of meiotic ZMM complex gene SPO16 in premature ovarian insufficiency., [RefSeq, PubMed]; Plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC) thereby stabilizing SC, ensuring progression of meiotic prophase I in male and female germ cells (By similarity). Promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1 (By similarity). Required for the localization of TEX11 and MSH4 to recombination intermediates (By similarity)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VVC4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005694 chromosome",
        "go_biological_process": "GO:0007130 synaptonemal complex assembly;GO:0007131 reciprocal meiotic recombination",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q5VVC0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z465-1",
        "uniprot_id": "BNIPL_HUMAN",
        "mass": 39713.0,
        "length": 357,
        "protein_name": "Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein",
        "gene_name": "BNIPL",
        "organism": "Human",
        "refseq_name": "bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform b",
        "refseq_ac": "NP_001153114",
        "gene_names_uniprotkb": "BNIPL",
        "gene_names_refseq": "BNIP-Salpha; BNIP-Sbeta; BNIP-S; BNIPL-1; BNIPL-2; BNIPL1; BNIPL2; BNIPL; BNIPS; PP753",
        "protein_names_uniprotkb": "Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein",
        "protein_names_refseq": "BCL2/adenovirus E1B 19kD interacting protein like; BNIP-2 similar; bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform b; bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:149428)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;11741952;12681488;12901880;15112343;16143817;20800603;23481700;29393594;29557506;30779550;31485655;38302910",
        "class_list": "",
        "function": "BNIPL is a promising biomarker of laryngeal cancer: novel insights from bioinformatics analysis and experimental validation. Publication Status: Online-Only, [RefSeq, PubMed]; BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis., [RefSeq, PubMed]; Data suggest that Bcl-2/adenovirus E1B 19 ku interacting protein 2-like (BNIPL-2) may regulate apoptosis through changes in the expression of genes associated with cell apoptosis, growth inhibition and cell proliferation., [RefSeq, PubMed]; Interaction with cell proliferation-related proteins, MIF and GFER, [RefSeq, PubMed]; May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; P16INK4, IL-12, TRAIL & lymphotoxin beta gene involved in growth suppression or cell apoptosis were up-regulated & PTEN was down-regulated by BNIPL-1;suggests that it might inhibit cell growth though cell cycle arrest &/or apoptotic cell death pathway(s), [RefSeq, PubMed]; The present study not only suggested that BNIPL2 may be a potential biomarker of CRC but also indicated that BNIPL2 regulates CRC cancer proliferation via CD44, which could be a diagnostic and clinical treatment target., [RefSeq, PubMed]; The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]., [RefSeq]; These results indicate the presence of two BNIP-S splicing variants as cellular regulators and that the BCH domain of BNIP-Salpha confers a novel apoptotic function. The significance of this is discussed, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6DK43;Q8TCY7;Q8WYG2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0040009 regulation of growth rate",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q7Z465-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z6A9-1",
        "uniprot_id": "BTLA_HUMAN",
        "mass": 32834.0,
        "length": 289,
        "protein_name": "B- and T-lymphocyte attenuator",
        "gene_name": "BTLA",
        "organism": "Human",
        "refseq_name": "B- and T-lymphocyte attenuator isoform 2 precursor",
        "refseq_ac": "NP_001078826",
        "gene_names_uniprotkb": "BTLA",
        "gene_names_refseq": "BTLA1; BTLA; CD272",
        "protein_names_uniprotkb": "B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein",
        "protein_names_refseq": "B- and T-lymphocyte attenuator isoform 2 precursor; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:151888);  (R-HSA-9927353)",
        "pathway_count": 2,
        "publication_count": 45,
        "publication_id_list": "12796776;14652006;15568026;15647361;16131544;16169851;16932752;18193050;19915044;23481700;24190977;25548167;25880248;25892735;26375851;27846572;27920218;28218747;28467828;28832583;28871256;29242379;29437277;29508533;29632711;29769354;30410026;31217245;31844290;32350084;32357974;32502341;32983136;33717175;33912179;34211107;35051231;35154160;35494241;36581221;37041226;37655751;38418488;38831106;38928307",
        "class_list": "",
        "function": "B- and T-lymphocyte attenuator could be a new player in accelerated atherosclerosis associated with chronic kidney disease., [RefSeq, PubMed]; BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4[+] T-cell exhaustion. Publication Status: Online-Only, [RefSeq, PubMed]; BTLA dysregulation correlates with poor outcome and diminished T cell-mediated antitumor responses in chronic lymphocytic leukemia., [RefSeq, PubMed]; Binding of HVEM to BTLA attenuates T cell activation, identifying HVEM/BTLA as a coinhibitory receptor pair., [RefSeq, PubMed]; Distinct herpesviruses target the HVEM-BTLA cosignaling pathway, suggesting the importance of this pathway in regulating T cell activation during host defenses., [RefSeq, PubMed]; HVEM binds to B T lymphocyte attenuator (BTLA), an Ig family member, which inhibits T cell proliferation., [RefSeq, PubMed]; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The BTLA-HVEM axis restricts CAR T cell efficacy in cancer., [RefSeq, PubMed]; The Immune Checkpoint BTLA in Oral Cancer: Expression Analysis and Its Correlation to Other Immune Modulators. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3B831;Q3HS85;Q6ZNH9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0002725 negative regulation of T cell cytokine production;GO:0042130 negative regulation of T cell proliferation;GO:0002250 adaptive immune response;GO:0030888 regulation of B cell proliferation;GO:0070372 regulation of ERK1 and ERK2 cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q7Z6A9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z7M8-1",
        "uniprot_id": "B3GN8_HUMAN",
        "mass": 43396.0,
        "length": 397,
        "protein_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 8",
        "gene_name": "B3GNT8",
        "organism": "Human",
        "refseq_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 8",
        "refseq_ac": "NP_940942",
        "gene_names_uniprotkb": "B3GNT8; B3GALT7; BGALT15",
        "gene_names_refseq": "B3GALT7; B3GNT8; BGALT15; beta3Gn-T8",
        "protein_names_uniprotkb": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 8; 2.4.1.149; BGnT-8; Beta-1,3-Gn-T8; Beta-1,3-N-acetylglucosaminyltransferase 8; Beta3Gn-T8; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8",
        "protein_names_refseq": "BGnT-8; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 8; UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 7; beta galactosyltransferase BGALT15; beta-1,3-Gn-T8; beta-1,3-N-acetylglucosaminyltransferase 8; beta1,3-N-acetylglucosaminyltransferase 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:374907);  (R-HSA-913709)",
        "pathway_count": 2,
        "publication_count": 38,
        "publication_id_list": "10330415;10430883;10753916;11042166;11283017;11304796;11821425;12855678;1329093;15486459;15560372;15620693;15917431;17113861;18537974;18826941;20963502;21468598;22183981;24643043;25269761;27459970;29393491;31844290;32350084;32488085;32945502;32983136;34185709;35051231;35251023;7655172;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Beta-1,3-N-acetylglucosaminyltransferase that functions in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans., [UniProtKB, PubMed, PubMed, PubMed]; Cjun plays a significant role in regulating the expression of beta3GnT8 in the SGC7901 cell line., [RefSeq, PubMed]; Highly expressed in lung, throat and ileum, whereas the expression level was low in tongue, breast, uteri, testis. In addition, it was also demonstrated that B3GALT7 is differentially transcribed in human tumor cell lines., [RefSeq, PubMed]; In conclusion, the alteration of b3GnT8 in colorectal cancer cells correlates with tumor sensitivity to the chemotherapeutic drug and has significant implication for the development of new treatment strategies., [RefSeq, PubMed]; Nglycosylation and receptor tyrosine kinase signaling affect claudin3 levels in colorectal cancer cells., [RefSeq, PubMed]; The cloning of a novel beta1,3-N-acetylglucosaminyltransferase that is upregulated in a human colon cancer cell line., [RefSeq, PubMed]; The down-regulation of beta3Gn-T8 caused significant inhibition of tumor cell growth in vitro., [RefSeq, PubMed]; These results reveal a new mechanism by which beta3Gn-T8 can regulate MMP-2 and TIMP-2., [RefSeq, PubMed]; These results revealed that b3GnT8 may play a key role in the development of oxaliplatin resistance in colon cancer cells possibly through the alteration of the glycosylation of integrin beta1. These findings may be valuable for overcoming drug resistance in colon cancer, [RefSeq, PubMed]; Up-regulation of beta3Gn-T8 in differentiated cells increases poly-N-acetyllactosamine chains by activating intrinsic beta3Gn-T2., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 515,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "2.4.1.-;2.4.1.147;2.4.1.149;2.4.1.206;2.4.1.146",
        "go_molecular_function": "GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016262 protein N-acetylglucosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0030311 poly-N-acetyllactosamine biosynthetic process",
        "synthesized_glycan_count": 1159,
        "hit_score": 3.9,
        "record_id": "Q7Z7M8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86V35-1",
        "uniprot_id": "CABP7_HUMAN",
        "mass": 24453.0,
        "length": 215,
        "protein_name": "Calcium-binding protein 7",
        "gene_name": "CABP7",
        "organism": "Human",
        "refseq_name": "calcium-binding protein 7",
        "refseq_ac": "NP_872333",
        "gene_names_uniprotkb": "CABP7; CALN2",
        "gene_names_refseq": "CABP7; CALN2",
        "protein_names_uniprotkb": "Calcium-binding protein 7; CaBP7; Calneuron II; Calneuron-2",
        "protein_names_refseq": "calcium-binding protein 7; calneuron 2; calneuron II",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:164633)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "17924679;19338761;22989873;25717182;32983136;33141586;33392160",
        "class_list": "",
        "function": "CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca(2+)-sensing by these family members., [RefSeq, PubMed]; CaBP7 regulates lysosome clustering at the intercellular bridge during cytokinesis in HeLa cells. CaBP7 depletion induces lysosome mislocalization, extension of intercellular bridge lifetime, and cytokinesis failure., [RefSeq, PubMed]; Data indicate that the Ca(2+)-bound form of calcium-binding protein 7 (CaBP7) N-terminal domain (NTD) is monomeric and exhibits an open conformation., [RefSeq, PubMed]; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q86V35-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IU99-1",
        "uniprot_id": "CAHM1_HUMAN",
        "mass": 38264.0,
        "length": 346,
        "protein_name": "Calcium homeostasis modulator protein 1",
        "gene_name": "CALHM1",
        "organism": "Human",
        "refseq_name": "calcium homeostasis modulator protein 1",
        "refseq_ac": "NP_001001412",
        "gene_names_uniprotkb": "CALHM1; FAM26C",
        "gene_names_refseq": "CALHM1; FAM26C",
        "protein_names_uniprotkb": "Calcium homeostasis modulator protein 1; Protein FAM26C",
        "protein_names_refseq": "calcium homeostasis modulator protein 1; family with sequence similarity 26, member C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:255022);  (R-HSA-9717207);  (R-HSA-9730628)",
        "pathway_count": 3,
        "publication_count": 58,
        "publication_id_list": "10761935;11917125;12015988;1325650;14634208;15353592;15385606;15738140;17167479;17506496;18585350;18667147;19038093;19070563;19104071;19191331;19191332;19472444;19545933;19655363;19696921;19997627;20022913;20033988;20061624;20164592;20847397;21378601;21422378;21574960;21795555;22711817;23300080;23345406;23467090;23481700;23632330;24157691;24214976;24360415;24633359;25853419;26377607;28256214;29466837;29659026;29744740;30013099;30563861;31844290;32832629;33141586;33199024;35051231;37380652;7720699;8288584;9065781",
        "class_list": "",
        "function": "No association with risk of late-onset Alzheimer disease (p=0.368 for genotypes; p=0.796 for alleles) was observed in the study, however, a potential modest association of minor allele homozygosity (TT) with an earlier age-at-onset was seen. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Pore-forming subunit of gustatory voltage-gated ion channels required for sensory perception of sweet, bitter and umami tastes (By similarity). With CALHM3 forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways (By similarity) (PubMed:23467090). Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to membrane depolarization and low extracellular Ca(2+) concentration (PubMed:22711817, PubMed:23300080). Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of small ions including Ca(2+), Na(+), K(+) and Cl(-), as well as larger ions such as ATP(4-) (PubMed:22711817, PubMed:23300080, PubMed:32832629, PubMed:37380652). Mediates Ca(2+) influx and downstream activation of the ERK1 and ERK2 cascade in neurons (PubMed:23345406). Triggers endoplasmic reticulum stress by reducing the Ca(2+) content of the endoplasmic reticulum (PubMed:21574960). May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+)-dependent manner (PubMed:18585350)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Protein may be a genetic determinant of Alzheimer disease, since a polymorphism reduces calcium permeability., [RefSeq, PubMed]; Study assessed the potential association between Alzheimer's Disease risk and the Pro86Leu variant in the CALHM1 gene; no association was observed, either in the individual samples or in the combined analyses of more than 8100 subjects, [RefSeq, PubMed]; Study determined that the CALHM1 P86L polymorphism is associated with Alzheimer's disease, further found that the P86L polymorphism increases amyloid-beta levels by interfering with CALHM1-mediated Ca(2+) permeability. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Study suggests the polymorphism does not contribute significantly to Alzheimer dementia risk in the Belgian population. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Thermosensitivity of the voltage-dependent activation of calcium homeostasis modulator 1 (calhm1) ion channel., [RefSeq, PubMed]; This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010]., [RefSeq]; [Review] Expression of CALHM1 is found in all brain regions and cells of neuronal lineage; it localizes predominantly to the endoplasmic reticulum but also exists at the plasma membrane, where it forms a novel calcium influx route to the cytosol. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 18,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5W091",
        "ec_number_list": "1.8.-.-;1.8.5.1;1.11.1.-;5.6.1.6;2.7.11.1",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005227 calcium-activated cation channel activity;GO:0005244 voltage-gated monoatomic ion channel activity;GO:0005261 monoatomic cation channel activity;GO:0005245 voltage-gated calcium channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0044853 plasma membrane raft;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization;GO:0006812 monoatomic cation transport;GO:0034765 regulation of monoatomic ion transmembrane transport;GO:0015867 ATP transport",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "Q8IU99-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IVY1-1",
        "uniprot_id": "CA210_HUMAN",
        "mass": 12024.0,
        "length": 113,
        "protein_name": "Type III endosome membrane protein TEMP",
        "gene_name": "C1orf210",
        "organism": "Human",
        "refseq_name": "type III endosome membrane protein TEMP",
        "refseq_ac": "NP_001158301",
        "gene_names_uniprotkb": "C1orf210",
        "gene_names_refseq": "C1orf210; TEMP",
        "protein_names_uniprotkb": "Type III endosome membrane protein TEMP; TEMP",
        "protein_names_refseq": "type III endosome membrane protein TEMP",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:149466)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "30459171",
        "class_list": "",
        "function": "May be involved in membrane trafficking between endosomes and plasma membrane., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DPX2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8IVY1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IWQ3-1",
        "uniprot_id": "BRSK2_HUMAN",
        "mass": 81633.0,
        "length": 736,
        "protein_name": "Serine/threonine-protein kinase BRSK2",
        "gene_name": "BRSK2",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase BRSK2 isoform 1",
        "refseq_ac": "NP_001243556",
        "gene_names_uniprotkb": "BRSK2; C11orf7; HUSSY-12; PEN11B; SADA; STK29",
        "gene_names_refseq": "BRSK2; C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase BRSK2; 2.7.11.1; 2.7.11.26; BR serine/threonine-protein kinase 2; Brain-selective kinase 2; Brain-specific serine/threonine-protein kinase 2; Serine/threonine-protein kinase 29; Serine/threonine-protein kinase SAD-A",
        "protein_names_refseq": "BR serine/threonine-protein kinase 2; brain-selective kinase 2; brain-specific serine/threonine-protein kinase 2; protein kinase SAD1B; serine/threonine-protein kinase 29; serine/threonine-protein kinase BRSK2 isoform 1; serine/threonine-protein kinase BRSK2; serine/threonine-protein kinase SAD-A; testicular tissue protein Li 30",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); depressive disorder (Disease Ontology:DOID:1596)",
        "pathway": " (hsa:9024)",
        "pathway_count": 1,
        "publication_count": 28,
        "publication_id_list": "11124703;11237011;14976552;16630837;16870137;17482548;18339622;19369195;19690332;19958286;20026642;21985311;22609399;22669945;22713462;22798068;23029325;23481700;29632046;30379171;30879638;32157095;32985588;33500714;34171305;35494241;37188647;9929968",
        "class_list": "",
        "function": "BRSK2 in pancreatic beta cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes., [RefSeq, PubMed]; Damaging variation in BRSK2 is a source of neurodevelopmental disease, [RefSeq, PubMed]; STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "reported_phosphosites": 19,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVE9;E9PLM7;O60843;O95099;Q5J5B4;Q6ZMQ4;Q8TB60",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0051117 ATPase binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm;GO:0150034 distal axon",
        "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0006468 protein phosphorylation;GO:0007409 axonogenesis;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q8IWQ3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IZY5-1",
        "uniprot_id": "BLID_HUMAN",
        "mass": 12045.0,
        "length": 108,
        "protein_name": "BH3-like motif-containing cell death inducer",
        "gene_name": "BLID",
        "organism": "Human",
        "refseq_name": "BH3-like motif-containing cell death inducer",
        "refseq_ac": "NP_001001786",
        "gene_names_uniprotkb": "BLID; BRCC2",
        "gene_names_refseq": "BLID; BRCC2",
        "protein_names_uniprotkb": "BH3-like motif-containing cell death inducer; Breast cancer cell protein 2",
        "protein_names_refseq": "BH3-like motif-containing cell death inducer; breast cancer cell 2; breast cancer cell protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:414899)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "15069058;18940476;19779542;20400521;20544842;21846966;23928696;24532431;31173853",
        "class_list": "",
        "function": "BLID gene is assigned to 11p24.1., [RefSeq, PubMed]; BLID is a new binding partner of Bcl-X(L) and a significant prognostic factor in breast cancer, [RefSeq, PubMed]; BLID upregulation resulting from a novel IGH translocation is associated with childhood B-Cell precursor acute lymphoblastic leukemia., [RefSeq, PubMed]; BRCC2 functions as a novel tumor suppressor in breast cancer and may be a potential therapeutic target for breast cancer management. Publication Status: Online-Only, [RefSeq, PubMed]; BRCC2 is a novel BH3-like domain-containing protein which induces apoptosis in a caspase-dependent manner, [RefSeq, PubMed]; Frequent loss of the BLID gene is observed in early-onset breast cancer., [RefSeq, PubMed]; Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death., [UniProtKB, PubMed]; Loss of BLID may contribute to the progression of intraductal proliferation lesions to breast cancer., [RefSeq, PubMed]; MiR-501 knockdown or BH3-like motif-containing protein, cell death inducer (BLID) overexpression could reverse the effects of ADR Exo on recipient cells. Erratum:[Cancer Lett. 2022 Jul 28;539:215695. doi: 10.1016/j.canlet.2022.215695. PMID: 35501203], [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a BH3-like motif containing protein involved in cell death. The encoded protein may induce apoptosis in a caspase-dependent manner. The protein is localized in both the cytoplasm and the mitochondrion. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L416",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8IZY5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N0U7-1",
        "uniprot_id": "CA087_HUMAN",
        "mass": 62035.0,
        "length": 546,
        "protein_name": "Uncharacterized protein C1orf87",
        "gene_name": "C1orf87",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C1orf87",
        "refseq_ac": "NP_689590",
        "gene_names_uniprotkb": "C1orf87",
        "gene_names_refseq": "C1orf87; CREF",
        "protein_names_uniprotkb": "Uncharacterized protein C1orf87",
        "protein_names_refseq": "carcinoma-related EF-hand protein; uncharacterized protein C1orf87",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:127795)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;16959974;20230923;28282151;29557506;30379171;31844290",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ZU07;Q8IVS0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005929 cilium;GO:0005930 axoneme",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8N0U7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N5C1-1",
        "uniprot_id": "CAHM5_HUMAN",
        "mass": 35170.0,
        "length": 309,
        "protein_name": "Calcium homeostasis modulator protein 5",
        "gene_name": "CALHM5",
        "organism": "Human",
        "refseq_name": "calcium homeostasis modulator protein 5",
        "refseq_ac": "NP_714922",
        "gene_names_uniprotkb": "CALHM5; C6orf188; FAM26E",
        "gene_names_refseq": "C6orf188; CALHM5; FAM26E; dJ493F7.3",
        "protein_names_uniprotkb": "Calcium homeostasis modulator protein 5; Protein FAM26E",
        "protein_names_refseq": "calcium homeostasis modulator protein 5; family with sequence similarity 26 member E; protein FAM26E",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:254228)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "29557506;29786170;30429286;31154438;32938616;33298887;34089472;35051231",
        "class_list": "",
        "function": "Human CALHM5: Insight in large pore lipid gating ATP channel and associated neurological pathologies. Review article, [RefSeq, PubMed]; May assemble to form large pore channels with gating and ion conductance likely regulated by membrane lipids., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDJ9;B3KSR3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005261 monoatomic cation channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:1904669 ATP export",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q8N5C1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NFL0-1",
        "uniprot_id": "B3GN7_HUMAN",
        "mass": 45987.0,
        "length": 401,
        "protein_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7",
        "gene_name": "B3GNT7",
        "organism": "Human",
        "refseq_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7",
        "refseq_ac": "NP_660279",
        "gene_names_uniprotkb": "B3GNT7",
        "gene_names_refseq": "B3GNT7; beta3GnT7",
        "protein_names_uniprotkb": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7; 2.4.1.-; BGnT-7; Beta-1,3-Gn-T7; Beta-1,3-N-acetylglucosaminyltransferase 7; Beta3Gn-T7",
        "protein_names_refseq": "BGnT-7; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7; beta 1,3-N-acetylglucosaminyltransferase 7; beta-1,3-Gn-T7; beta3Gn-T7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:93010);  (R-HSA-2022854);  (R-HSA-913709)",
        "pathway_count": 3,
        "publication_count": 62,
        "publication_id_list": "10.1074/mcp.M114.046862;10206952;10330415;10430883;10491328;10504389;10753916;11030741;11042166;11042394;11237011;11283017;11304796;11588157;11821425;11901181;12061784;12218059;12855678;1329093;14706853;15486459;15560372;15620693;17021253;17113861;1714903;17690104;18537974;22183981;24418929;24643043;25813380;25892735;28904123;29242379;29314611;29557506;29769354;29789417;31844290;32350084;32897882;33936100;34357683;34864058;35051231;36215666;37740763;38034954;7655172;8333853;8611500;8920913;9295285;9394011;9405439;9417100;9435216;9597550;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Identification of glycogene-based prognostic signature and validation of B3GNT7 as a potential biomarker and therapeutic target in breast cancer., [RefSeq, PubMed]; Interleukin-22 regulates B3GNT7 expression to induce fucosylation of glycoproteins in intestinal epithelial cells., [RefSeq, PubMed]; N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non-reducing terminal galactose (Gal) in the linearly growing chain of N-and O-linked keratan sulfate proteoglycans. Cooperates with B4GALT4 galactosyltransferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (PubMed:14706853, PubMed:17690104). Involved in biosynthesis of N-linked keratan sulfate proteoglycans in cornea, with an impact on proteoglycan fibril organization and corneal transparency (By similarity) (PubMed:17690104). May play a role in the maintenance of tissue architecture by suppressing cellular motility and invasion (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; Sulfated keratan sulfate is produced by beta3GNT7, beta4GalT4, CGn6ST, and KSG6ST, [RefSeq, PubMed]; The nude mice xenograft model demonstrated that ectopic expression of the B3GNT7 gene in colon cancer cells diminished the migration capability and the liver-metastasis potential, respectively, of colon cancer cells., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 481,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWY4;B7WNP0",
        "ec_number_list": "2.4.1.-;2.4.1.147;2.4.1.149;2.4.1.206;2.4.1.146",
        "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity;GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016787 hydrolase activity;GO:0004519 endonuclease activity",
        "go_cellular_component": "GO:0000139 Golgi membrane",
        "go_biological_process": "GO:0018146 keratan sulfate proteoglycan biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "Q8NFL0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P12643-1",
        "uniprot_id": "BMP2_HUMAN",
        "mass": 44702.0,
        "length": 396,
        "protein_name": "Bone morphogenetic protein 2",
        "gene_name": "BMP2",
        "organism": "Human",
        "refseq_name": "bone morphogenetic protein 2 preproprotein",
        "refseq_ac": "NP_001191",
        "gene_names_uniprotkb": "BMP2; BMP2A",
        "gene_names_refseq": "BDA2; BMP2A; BMP2; SSFSC1; SSFSC",
        "protein_names_uniprotkb": "Bone morphogenetic protein 2; BMP-2A; BMP-2; Bone morphogenetic protein 2A",
        "protein_names_refseq": "bone morphogenetic protein 2 preproprotein; bone morphogenetic protein 2A",
        "tax_id": 9606,
        "disease": "tooth agenesis (Disease Ontology:DOID:0050591); juvenile polyposis syndrome (Disease Ontology:DOID:0050787); short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1 (Disease Ontology:DOID:0060989); brachydactyly type A2 (Disease Ontology:DOID:0110965); hemochromatosis type 1 (Disease Ontology:DOID:0111029); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); otosclerosis (Disease Ontology:DOID:12185); Marfan syndrome (Disease Ontology:DOID:14323); osteoarthritis (Disease Ontology:DOID:8398)",
        "pathway": " (hsa:650);  (R-HSA-201451);  (R-HSA-2129379);  (R-HSA-8878166);  (R-HSA-8939902)",
        "pathway_count": 5,
        "publication_count": 116,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10025398;10074410;10215629;10424889;10458166;10544250;10572046;10587654;10646116;10712517;10911365;10930463;11016919;11121043;11158580;11278251;11509558;11571290;11714695;11779505;11857736;11970960;12000792;12151385;12358597;12391164;12415008;12429738;12434152;12434156;12519765;12592392;12738770;12821673;12857866;12923053;1400330;14701737;15020244;15030764;15064755;15703179;16115867;16407259;16421188;16672363;16728642;16771708;17029022;17068149;1708799;17142326;17171635;17295905;17311849;17324935;17356069;17786208;18184661;18223689;18339631;18436533;18541707;19144722;19327734;20555025;20851880;21357617;21646718;21913213;21931630;22065775;22422618;22544321;23403054;23584533;23943595;24336949;24362451;24850862;25260729;25576301;26091038;26778333;28467828;29198724;29557506;31019025;31800957;3201241;32157095;32938616;32983136;33308444;35051231;38510491;38609424;38610001;38786031;39118176;7500359;7534784;7644468;7791754;8119126;8620887;8653785;8893010;9136927;9182764;9207800;9265423;9436979;9725916",
        "class_list": "",
        "function": "Exploring the Regulators of Keratinization: Role of BMP-2 in Oral Mucosa. Publication Status: Online-Only, [RefSeq, PubMed]; Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis (PubMed:18436533, PubMed:24362451, PubMed:31019025). Induces cartilage and bone formation (PubMed:3201241). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:15064755, PubMed:17295905, PubMed:18436533). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A (PubMed:7791754). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3 (PubMed:31800957). Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation (PubMed:16771708, PubMed:20851880). Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Long non-coding TRPM2-AS regulates fracture healing by targeting miR-545-3p/Bmp2. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-beta/Smads/MAPK. Publication Status: Online-Only, [RefSeq, PubMed]; RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]., [RefSeq]; Whole genome sequencing identifies associations for nonsyndromic sagittal craniosynostosis with the intergenic region of BMP2 and noncoding RNA gene LINC01428. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 3,
        "mined_n_glycosites": 3,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 12,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding;GO:0019211 phosphatase activator activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0032991 protein-containing complex;GO:0070724 BMP receptor complex",
        "go_biological_process": "GO:0030316 osteoclast differentiation;GO:1901331 positive regulation of odontoblast differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0001934 positive regulation of protein phosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "P12643-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95947-1",
        "uniprot_id": "TBX6_HUMAN",
        "mass": 47045.0,
        "length": 436,
        "protein_name": "T-box transcription factor TBX6",
        "gene_name": "TBX6",
        "organism": "Human",
        "refseq_name": "T-box transcription factor TBX6",
        "refseq_ac": "NP_004599",
        "gene_names_uniprotkb": "TBX6",
        "gene_names_refseq": "SCDO5; TBX6",
        "protein_names_uniprotkb": "T-box transcription factor TBX6; T-box protein 6",
        "protein_names_refseq": "T-box 6; T-box protein 6; T-box transcription factor TBX6",
        "tax_id": 9606,
        "disease": "scoliosis (Disease Ontology:DOID:0060249); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); spondylocostal dysostosis 5 (Disease Ontology:DOID:0112363)",
        "pathway": " (hsa:6911);  (R-HSA-9793380);  (R-HSA-9824272);  (R-HSA-9832991)",
        "pathway_count": 4,
        "publication_count": 21,
        "publication_id_list": "17584735;18466071;19561075;20074535;23335591;25564734;28054739;28178531;28904123;30379171;31844290;32357974;32938616;33058178;33298915;33912179;35051231;36112137;36161696;9888994;9933572",
        "class_list": "",
        "function": "An additional piece in the TBX6 gene dosage model: A novel nonsense variant in a fetus with severe spondylocostal dysostosis., [RefSeq, PubMed]; Functional characteristics of a broad spectrum of TBX6 variants in Mayer-Rokitansky-Kuster-Hauser syndrome., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity)., [UniProtKB]; TBX6 as a cause of a combined skeletal-kidney dysplasia syndrome., [RefSeq, PubMed]; Tbx18 interacts with Gata4 and Nkx2-5 and competes Tbx5-mediated activation of the cardiac Natriuretic peptide precursor type a-promoter. Tbx18 down-regulates Tbx6-activated Delta-like 1 expression in the somitic mesoderm in vivo, [RefSeq, PubMed]; This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. [provided by RefSeq, Aug 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8TAS4;Q9HA44",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003714 transcription corepressor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0001708 cell fate specification;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "O95947-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P48742-1",
        "uniprot_id": "LHX1_HUMAN",
        "mass": 44808.0,
        "length": 406,
        "protein_name": "LIM/homeobox protein Lhx1",
        "gene_name": "LHX1",
        "organism": "Human",
        "refseq_name": "LIM/homeobox protein Lhx1",
        "refseq_ac": "NP_005559",
        "gene_names_uniprotkb": "LHX1; LIM-1; LIM1",
        "gene_names_refseq": "LHX1; LIM-1; LIM1",
        "protein_names_uniprotkb": "LIM/homeobox protein Lhx1; Homeobox protein Lim-1; LIM homeobox protein 1; hLim-1",
        "protein_names_refseq": "LIM homeobox protein 1; LIM/homeobox protein Lhx1; homeobox protein Lim-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3975);  (R-HSA-9761174);  (R-HSA-9830364);  (R-HSA-9831926)",
        "pathway_count": 4,
        "publication_count": 6,
        "publication_id_list": "11237011;24357672;28600106;30076415;36215666;9212161",
        "class_list": "",
        "function": "Our MRKH families included 43 quads, 26 trios, and 30 duos. Of our MRKH probands, 87/147 (59%) had MRKH type 1 and 60/147 (41%) had type 2 with additional anomalies. CONCLUSION(S): Although the prevalence of WNT4, HNF1B, and LHX1 point mutations is low in people with MRKH, the prevalence of CNVs was approximately 19%., [RefSeq, PubMed]; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis., [UniProtKB, PubMed]; The potential pro-metastatic role of Lim1 in advanced clear cell renal cell carcinoma in vitro, ex vivo, and in vivo in a nude mouse model. Lim1 was found constitutively expressed in all metastatic tissues. Lim1 silencing decreased pulmonary metastasis in the in vivo model. Lim1 is involved in the expression of various proteins regulating cell movements and EMT, and induced clonogenicity in CCC cells., [RefSeq, PubMed]; This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3MIW0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0060429 epithelium development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007267 cell-cell signaling;GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "P48742-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P0T4-1",
        "uniprot_id": "ZN581_HUMAN",
        "mass": 22010.0,
        "length": 197,
        "protein_name": "Zinc finger protein 581",
        "gene_name": "ZNF581",
        "organism": "Human",
        "refseq_name": "zinc finger protein 581",
        "refseq_ac": "NP_057619",
        "gene_names_uniprotkb": "ZNF581; HSPC189",
        "gene_names_refseq": "HSPC189; ZNF581",
        "protein_names_uniprotkb": "Zinc finger protein 581",
        "protein_names_refseq": "zinc finger protein 581",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51545)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;27846572;28063628;28218747;29331515;29632046;30429286;31844290;31848261;32265295;33691108;33936100",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDM6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9P0T4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6QNY1-1",
        "uniprot_id": "BL1S2_HUMAN",
        "mass": 15961.0,
        "length": 142,
        "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 2",
        "gene_name": "BLOC1S2",
        "organism": "Human",
        "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 2",
        "refseq_ac": "NP_001001342",
        "gene_names_uniprotkb": "BLOC1S2; BLOS2; CEAP",
        "gene_names_refseq": "BLOC1S2; BLOS2; BORCS2; CEAP11; CEAP",
        "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 2; BLOC-1 subunit 2; Centrosome-associated protein",
        "protein_names_refseq": "11 kDa centrosome associated protein; BLOC-1 subunit 2; biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 2; biogenesis of lysosome-related organelles complex 1 subunit 2; centrosomal 10 kDa protein; centrosome protein oncogene",
        "tax_id": 9606,
        "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)",
        "pathway": " (hsa:282991)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15102850;15381421;17182842;22203680;25898167;26375851;26992070;28218747;28832583;28855257;28904123;29242379;29393594;29437277;29557506;29786170;31217245;31844290;32161166;32387766;32488085;32938616;32983136;33141586;33912179;33968037;34171305;34357683;34509645;35051231;35580925;36010968",
        "class_list": "",
        "function": "Biogenesis of lysosome-related organelles complex-1 (BLOC-1) subunit 2 (BLOS2).BLOC-1 is required for the biogenesis of melanosomes and platelet dense granules., [RefSeq, PubMed]; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a protein with multiple functions. The encoded protein has been found in association with the centrosome, shown to co-localize with gamma-tubulin, and also found to be one of the proteins in the BLOC-1 complex which functions in the formation of lysosome-related organelles. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DQV2;Q5W040;Q8WUI8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0043015 gamma-tubulin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol;GO:1904115 axon cytoplasm",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0031175 neuron projection development;GO:0045893 positive regulation of DNA-templated transcription;GO:0016197 endosomal transport;GO:0060155 platelet dense granule organization",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q6QNY1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UL15-1",
        "uniprot_id": "BAG5_HUMAN",
        "mass": 51200.0,
        "length": 447,
        "protein_name": "BAG family molecular chaperone regulator 5",
        "gene_name": "BAG5",
        "organism": "Human",
        "refseq_name": "BAG family molecular chaperone regulator 5",
        "refseq_ac": "NP_001015048",
        "gene_names_uniprotkb": "BAG5; KIAA0873",
        "gene_names_refseq": "BAG-5; BAG5; CMD2F",
        "protein_names_uniprotkb": "BAG family molecular chaperone regulator 5; BAG-5; Bcl-2-associated athanogene 5",
        "protein_names_refseq": "BAG family molecular chaperone regulator 5; BCL2 associated athanogene 5; bcl-2-associated athanogene 5",
        "tax_id": 9606,
        "disease": "dilated cardiomyopathy 2F (Disease Ontology:DOID:0081162)",
        "pathway": " (hsa:9529);  (R-HSA-3371453)",
        "pathway_count": 2,
        "publication_count": 85,
        "publication_id_list": "10954706;11747420;12853476;12917326;12974469;15364926;15603737;15802566;1586970;16278218;1754405;18235501;18235502;18550409;19229036;19913121;19914676;20223214;22465953;22541429;22735644;22940245;23301498;23349863;23481700;24270810;24715725;25576301;25880248;25892735;26154972;26375851;26992070;27846572;28228285;28832583;28834231;29242379;29317506;29508533;29557506;29632046;29632711;29786170;29789417;30315122;30429286;30779550;31154438;31530632;31844290;31848261;31937595;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33592498;33717175;33912179;33968037;33981976;34087483;34171305;34561969;35044787;35051231;35318648;35580925;36241641;37938771;38139359;40914422;7585962;8721986;8946918;9305631;9873016;9920933",
        "class_list": "",
        "function": "Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch. Publication Status: Online-Only, [RefSeq, PubMed]; Bcl-2-associated athanogene 5 (BAG5) is a negative regulator of both Hsp70 and parkin function that sensitizes dopaminergic neurons to injury-induced death., [RefSeq, PubMed]; Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (PubMed:20223214). Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O94950;Q86W59",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0000774 adenyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0031397 negative regulation of protein ubiquitination;GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "Q9UL15-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P55273-1",
        "uniprot_id": "CDN2D_HUMAN",
        "mass": 17700.0,
        "length": 166,
        "protein_name": "Cyclin-dependent kinase 4 inhibitor D",
        "gene_name": "CDKN2D",
        "organism": "Human",
        "refseq_name": "cyclin-dependent kinase 4 inhibitor D",
        "refseq_ac": "NP_001791",
        "gene_names_uniprotkb": "CDKN2D",
        "gene_names_refseq": "CDKN2D; INK4D; p19-INK4D; p19",
        "protein_names_uniprotkb": "Cyclin-dependent kinase 4 inhibitor D; p19-INK4d",
        "protein_names_refseq": "CDK inhibitor p19INK4d; cell cycle inhibitor, Nur77 associating protein; cyclin-dependent kinase 4 inhibitor D p19; cyclin-dependent kinase 4 inhibitor D; cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); inhibitor of cyclin-dependent kinase 4d",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1032);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559585);  (R-HSA-69231)",
        "pathway_count": 5,
        "publication_count": 203,
        "publication_id_list": "10207050;10347217;10358095;10385618;10390011;10432220;10499802;10548110;10722742;10734227;10772813;10831586;10871633;11032757;11073976;11114305;11157749;11231573;11234019;11340163;11416152;11564866;11719808;11782450;11883935;11884610;12134156;12189133;12193592;12421820;12435631;12435635;12444543;12665801;12808055;12832467;13130464;1423597;14507994;14517297;14532106;14597415;14679213;14729966;15287722;15563468;15572696;15579463;15774718;15866172;16186825;16195327;16211008;16337592;16436515;16626623;16782892;16826196;17092340;17210787;17254966;17254967;17254968;17255097;17332741;17344414;17395714;17765224;17825402;17875933;17908796;18267069;1828392;1828393;1828394;18365017;18411265;18414028;18555777;18555778;18710949;18793328;18827403;19063602;19075005;19451217;19451218;19458076;19462008;19487459;19528227;19805069;20107323;20351173;20452968;20534573;20663872;20843055;20952511;21423214;21715330;2183031;21979375;21986495;22020331;22178396;22325352;22336108;22558186;22634325;22683641;23007395;23622515;23737759;23846687;2405250;24515438;24706756;24876129;25418920;25733683;26154972;26992070;27862975;27920218;28832583;28834231;28904123;29242379;29531090;29557506;29632046;29786170;30711375;31543423;31844290;31848261;32157095;32357974;32387766;32502341;32874495;32938616;32983136;33298915;33968037;34932366;35580925;36292630;38378843;7535770;7588608;7588633;7739548;7797074;7816143;7859739;7954814;8001816;8078588;8114739;8139570;8234276;8246996;8259215;8319905;8336704;8384717;8413215;8413306;8497257;8552081;8575754;8617720;8622669;8622688;8626550;8688489;8741839;8774846;8846784;8884985;8939459;8974401;9030721;9042862;9106657;9144196;9162092;9190208;9195981;9325318;9447971;9448290;9482106;9508775;9529249;9564042;9628874;9751050;9768359;9782052;9824166",
        "class_list": "",
        "function": "Deregulation of the p19/CDK4/CDK6 axis in Jak2[V617F] megakaryocytes accelerates the development of myelofibrosis., [RefSeq, PubMed]; Identification of <i>Cdk8</i> and <i>Cdkn2d</i> as New Prame-Target Genes in 2C-like Embryonic Stem Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Interacts strongly with CDK4 and CDK6 and inhibits them., [UniProtKB, PubMed, PubMed]; The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q13102;Q6FGE9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097129 cyclin D2-CDK4 complex",
        "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0032526 response to retinoic acid;GO:0030308 negative regulation of cell growth;GO:0009411 response to UV",
        "synthesized_glycan_count": 0,
        "hit_score": 20.4,
        "record_id": "P55273-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NV96-1",
        "uniprot_id": "CC50A_HUMAN",
        "mass": 40684.0,
        "length": 361,
        "protein_name": "Cell cycle control protein 50A",
        "gene_name": "TMEM30A",
        "organism": "Human",
        "refseq_name": "cell cycle control protein 50A isoform 2",
        "refseq_ac": "NP_001137430",
        "gene_names_uniprotkb": "TMEM30A; C6orf67; CDC50A",
        "gene_names_refseq": "C6orf67; CDC50A; TMEM30A",
        "protein_names_uniprotkb": "Cell cycle control protein 50A; P4-ATPase flippase complex beta subunit TMEM30A; Transmembrane protein 30A",
        "protein_names_refseq": "P4-ATPase flippase complex beta subunit TMEM30A; cell cycle control protein 50A isoform 2; cell cycle control protein 50A; transmembrane protein 30A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55754);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 109,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;11237011;15375526;17948906;19159218;19349973;20510206;20947505;20961850;21289302;21454556;21914794;22645359;23584533;23650620;23783831;24190977;24397554;24715725;25502872;25576301;25645385;25813380;25892735;25947375;26024233;26154972;26992070;27397612;27846572;27862975;27920218;28218747;28228285;28467828;28489076;28832583;28834231;28855257;28904123;29242379;29314611;29317506;29393594;29437277;29493099;29557506;29632046;29769354;29786170;29799007;30315122;30410026;30429286;30484775;30524438;30573663;30779550;30833945;31154438;31217245;31416931;31530632;31611695;31844290;31848261;32157095;32161166;32350084;32488085;32493773;32897882;32938616;32983136;33043033;33123756;33141586;33392160;33592498;33633747;33717175;33912179;33936100;33968037;34019948;34080006;34171305;34185709;34357683;34433824;34561969;34664668;34725712;34932366;35051231;35154160;35251023;35494241;35580925;36010968;36215666;36241641;36284347;37074911;38557174;38665916;8692836",
        "class_list": "",
        "function": "Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; CDC50A is required for aminophospholipid transport and cell fusion in mouse C2C12 myoblasts., [RefSeq, PubMed]; CDC50A may be the potential beta-subunit or chaperone for ATP8B1 in hepatocytes., [RefSeq, PubMed]; Deletion of the TMEM30A gene enables leukemic cell evasion of NK cell cytotoxicity., [RefSeq, PubMed]; Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 36,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9V8;E1P539;Q658Z3;Q96H09;Q9NSL9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005198 structural molecule activity;GO:0015247 aminophospholipid flippase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0035579 specific granule membrane",
        "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0045332 phospholipid translocation;GO:0036010 protein localization to endosome;GO:0006855 xenobiotic transmembrane transport;GO:0061092 positive regulation of phospholipid translocation",
        "synthesized_glycan_count": 0,
        "hit_score": 15.5,
        "record_id": "Q9NV96-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95678-1",
        "uniprot_id": "K2C75_HUMAN",
        "mass": 59560.0,
        "length": 551,
        "protein_name": "Keratin, type II cytoskeletal 75",
        "gene_name": "KRT75",
        "organism": "Human",
        "refseq_name": "keratin, type II cytoskeletal 75",
        "refseq_ac": "NP_004684",
        "gene_names_uniprotkb": "KRT75; K6HF; KB18",
        "gene_names_refseq": "CK-75; K6HF; K75; KB18; KRT75; PFB; hK6hf",
        "protein_names_uniprotkb": "Keratin, type II cytoskeletal 75; CK-75; Cytokeratin-75; K75; Keratin-6 hair follicle; Keratin-75; Type II keratin-K6hf; Type-II keratin Kb18; hK6hf",
        "protein_names_refseq": "cytokeratin type II; cytokeratin-75; keratin 75, type II; keratin, type II cytoskeletal 75; keratin-6 hair follicle; type II keratin-18; type II keratin-K6hf; type-II keratin Kb18",
        "tax_id": 9606,
        "disease": "loose anagen hair syndrome (Disease Ontology:DOID:0111702); Pseudofolliculitis barbae (MONDO:MONDO:0012865)",
        "pathway": " (hsa:9119);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 3,
        "publication_count": 81,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10692104;10771479;11350120;11380615;11590230;11939812;12902340;14675170;15033990;15086549;15292489;15337775;15373777;15797384;15803139;16061697;16382671;16639001;1691188;1694855;17081983;1714783;17515931;17521629;17562024;17596512;18032949;18669648;18767875;18843291;19190773;19194479;20068231;20179351;20657595;20667819;20940292;21439340;21654840;21997417;22121020;23481192;23629652;2414304;25208914;25347471;25742793;25926655;26390218;26709044;26853435;27130144;29331515;29557506;31217245;31611695;31844290;32350084;32373127;32387766;32488085;33981976;34019948;34078123;34211107;35051231;35580925;37217939;38665916;7543090;8824274;8999895;9395522;9468612;9565599;9856802",
        "class_list": "",
        "function": "Analysis of teeth from individuals carrying the KRT75(A161T) variant revealed an altered enamel structure and a marked reduction of enamel hardness, suggesting that a functional keratin network is required for the mechanical stability of tooth enamel., [RefSeq, PubMed]; CK5/6 have roles in biologically aggressive tumors likely to display resistance to trastuzumab ab initio in women diagnosed with HER2+ cancer, [RefSeq, PubMed]; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle., [UniProtKB]; Studies show that mutation in epithelial hair keratin KRT75 leads to a skin condition called pseudofollicularis barbae. Carriers of this mutation have an altered enamel structure and mechanical properties leading to much higher prevalence of caries. [review] Review article, [RefSeq, PubMed]; The expression of CK5/6 and of P63 suggests a squamous differentiation including in the basaloid thyroid lymphoepithelial complexes, [RefSeq, PubMed]; This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DQU4;Q9NSA9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005198 structural molecule activity;GO:0030280 structural constituent of skin epidermis",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0005882 intermediate filament;GO:0001533 cornified envelope;GO:0045095 keratin filament",
        "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "O95678-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P01042-1",
        "uniprot_id": "KNG1_HUMAN",
        "mass": 71957.0,
        "length": 644,
        "protein_name": "Kininogen-1",
        "gene_name": "KNG1",
        "organism": "Human",
        "refseq_name": "kininogen-1 isoform 2 precursor",
        "refseq_ac": "NP_000884",
        "gene_names_uniprotkb": "KNG1; BDK; KNG",
        "gene_names_refseq": "BDK; BK; HAE6; HK; HMWK; KNG1; KNG",
        "protein_names_uniprotkb": "Kininogen-1; Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; HMWK; High molecular weight kininogen; Ile-Ser-Bradykinin; Kallidin II; Kallidin I; Williams-Fitzgerald-Flaujeac factor",
        "protein_names_refseq": "alpha-2-thiol proteinase inhibitor; bradykinin; fitzgerald factor; high molecular weight kininogen; kininogen-1 isoform 2 precursor; williams-Fitzgerald-Flaujeac factor",
        "tax_id": 9606,
        "disease": "stroke (Disease Ontology:DOID:0051061); high molecular weight kininogen deficiency (Disease Ontology:DOID:0111676); IgA vasculitis (Disease Ontology:DOID:11123); hereditary angioedema (Disease Ontology:DOID:14735); abdominal aortic aneurysm (Disease Ontology:DOID:7693); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); angioedema, hereditary, 6 (MONDO:MONDO:0023660)",
        "pathway": " (hsa:3827);  (R-HSA-114608);  (R-HSA-375276);  (R-HSA-381426);  (R-HSA-416476);  (R-HSA-418594);  (R-HSA-8957275);  (R-HSA-9855719);  (R-HSA-9935598);  (R-HSA-9970672)",
        "pathway_count": 10,
        "publication_count": 299,
        "publication_id_list": "37268159;10.1021/acs.analchem.6b02887;10026136;10077652;10079109;10100623;10191087;10218588;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10512690;10567430;10604470;10614670;1066663;10681634;10727532;10810289;10854085;10861009;10898936;10899166;10912521;10951195;10990447;11007482;11015615;11158056;11204562;11250653;11264294;11316783;11322507;11385580;11457843;11522292;11562423;11606061;11683476;11739083;11742120;11751371;11753430;11773063;11788658;11830581;11986212;12120503;12241545;12379487;12427552;12466191;12540846;12719537;12754519;1280419;12810533;12904166;12944405;12956774;1314587;1317848;1325670;1337145;1346068;1370451;1383255;1435334;14463577;14550283;14573733;14630798;14691562;14760718;14977046;15118850;15126567;15139756;15297306;15308688;15469690;15485880;15525596;15539556;15642270;1567413;15711755;15947423;15951850;16169873;16182515;16268778;16335952;16339447;1655761;16634148;16754659;16923326;17047378;1710450;1710578;1719979;1722333;17249697;17312271;17645545;17975675;17985932;18127230;18434541;1847994;18515384;18577758;18936096;1905813;19139490;19159218;19824718;19838169;1998667;20166139;20187088;2076202;21081667;21304106;21544310;21683246;23090970;23446738;23505046;23640497;23690594;24275569;24279413;24417605;24530628;2476804;2479552;24906252;25265424;2534964;2578463;2579948;26091039;2649896;26598643;27452731;2748346;27496565;27726376;27862975;28035807;2834384;2841328;29314611;29371260;29391424;29493099;29519898;29557506;29632711;29671580;29741879;29786170;29789417;2989293;2989294;30237853;30315122;30429286;30459171;3086311;3099750;31087670;31154438;3182782;31844290;3202875;32125861;32157095;32350084;32983136;33091337;33114181;33397811;3366244;33827130;34171305;34494203;34561969;34725484;3484703;35051231;35251023;3525564;35580925;36934370;37074911;37442062;3756141;37703419;3828072;3856870;3877053;3886654;4054110;4178758;4322742;4703226;4952632;500690;588558;6055465;6203908;6274691;6281660;6373251;6441591;6457647;6589611;6604055;7057924;7391081;7519608;7523391;7524088;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7589467;7590751;7592910;7592911;7624359;7683646;7689487;7797512;7905839;7937899;8015379;8035319;8062389;8063797;8185599;8195709;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8406495;8440682;8463333;8467233;8503909;8615752;8664309;8666380;8702752;8710908;873923;874082;8760820;8781553;8817670;8823230;8894645;893417;8964575;9171878;9226169;9305846;9427705;9497324;9521323;9530155;9593744;9607765;9685625;9709957;9722565;9733769;9770463;9786878;9792798;9832121;9851594;9922210",
        "class_list": "",
        "function": "An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons alpha and lambda1 in HBV infection by promoting MAVS lysosomal degradation., [RefSeq, PubMed]; Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons., [RefSeq, PubMed]; GC1qR Antibody Can Modulate Endothelial Cell Permeability in Angioedema., [RefSeq, PubMed]; High preoperative bradykinin level is a risk factor for severe postoperative hypoxaemia in acute aortic dissection surgery., [RefSeq, PubMed]; Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting., [UniProtKB]; Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure., [RefSeq, PubMed]; The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action)., [UniProtKB, PubMed, PubMed]; The antimicrobial protein kininogen evolved adaptively in mammals and human populations., [RefSeq, PubMed]; This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2020]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 6,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 26,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 26,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 26,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 63,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 191,
        "disease_count": 7,
        "glyco_site_count": 34,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K474;B2RCR2;C9JEX1;P01043;Q53EQ0;Q6PAU9;Q7M4P1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0008270 zinc ion binding;GO:0005179 hormone activity;GO:0004869 cysteine-type endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0007162 negative regulation of cell adhesion;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0043065 positive regulation of apoptotic process;GO:0007596 blood coagulation",
        "synthesized_glycan_count": 0,
        "hit_score": 52.2,
        "record_id": "P01042-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P43361-1",
        "uniprot_id": "MAGA8_HUMAN",
        "mass": 35215.0,
        "length": 318,
        "protein_name": "Melanoma-associated antigen 8",
        "gene_name": "MAGEA8",
        "organism": "Human",
        "refseq_name": "melanoma-associated antigen 8",
        "refseq_ac": "NP_001159872",
        "gene_names_uniprotkb": "MAGEA8; MAGE8",
        "gene_names_refseq": "CT1.8; MAGE8; MAGEA8",
        "protein_names_uniprotkb": "Melanoma-associated antigen 8; CT1.8; Cancer/testis antigen 1.8; MAGE-8 antigen",
        "protein_names_refseq": "MAGE-8 antigen; cancer/testis antigen 1.8; cancer/testis antigen family 1, member 8; melanoma antigen family A, 8; melanoma antigen family A8; melanoma-associated antigen 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4107)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "32002290;32938616;34405274;35472243;35874702;36010968;37100770;7927540",
        "class_list": "",
        "function": "Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression., [UniProtKB]; This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BUN9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042826 histone deacetylase binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "P43361-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P49901-1",
        "uniprot_id": "MCSP_HUMAN",
        "mass": 12767.0,
        "length": 116,
        "protein_name": "Sperm mitochondrial-associated cysteine-rich protein",
        "gene_name": "SMCP",
        "organism": "Human",
        "refseq_name": "sperm mitochondrial-associated cysteine-rich protein",
        "refseq_ac": "NP_109588",
        "gene_names_uniprotkb": "SMCP; MCSP; MCS",
        "gene_names_refseq": "HSMCSGEN1; MCSP; MCS; SMCP",
        "protein_names_uniprotkb": "Sperm mitochondrial-associated cysteine-rich protein",
        "protein_names_refseq": "sperm mitochondrial-associated cysteine-rich protein; testicular tissue protein Li 119; testicular tissue protein Li 161",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4184)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "16325371;24244262;8833144",
        "class_list": "",
        "function": "Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity)., [UniProtKB]; Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]., [RefSeq]; The initiation results indicate that an ectopically expressed variant form of SMCP has a role in tumor initiation of CSCs/CICs and that the variant form of SMCP might be a novel CSC/CIC marker Publication Status: Online-Only, [RefSeq, PubMed]; The levels of SMCP mRNA in human are much lower than in other mammals., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96A42",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane",
        "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007341 penetration of zona pellucida",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "P49901-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P53673-1",
        "uniprot_id": "CRBA4_HUMAN",
        "mass": 22374.0,
        "length": 196,
        "protein_name": "Beta-crystallin A4",
        "gene_name": "CRYBA4",
        "organism": "Human",
        "refseq_name": "beta-crystallin A4",
        "refseq_ac": "NP_001877",
        "gene_names_uniprotkb": "CRYBA4",
        "gene_names_refseq": "CRYBA4; CTRCT23; CYRBA4; MCOPCT4",
        "protein_names_uniprotkb": "Beta-crystallin A4; Beta-A4 crystallin",
        "protein_names_refseq": "beta crystallin A4 chain transcript PS; beta crystallin alpha 4 chain; beta-A4 crystallin; beta-crystallin A4; crystallin, beta polypeptide A4; eye lens structural protein",
        "tax_id": 9606,
        "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); carnitine palmitoyltransferase I deficiency (Disease Ontology:DOID:0090129); cataract 23 (Disease Ontology:DOID:0110271); alcoholic hepatitis (Disease Ontology:DOID:12351); lipid metabolism disorder (Disease Ontology:DOID:3146); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); end stage renal disease (Disease Ontology:DOID:783); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:1413)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "12060738;16960806;20577656;31935276;33298915;33936100;35580925;35840783;7504514;8999933",
        "class_list": "",
        "function": "A novel missense variant c.71G > T (p.Gly24Val) of the CRYBA4 gene contributes to autosomal-dominant congenital cataract in a Chinese family., [RefSeq, PubMed]; Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, is part of a gene cluster with beta-B1, beta-B2, and beta-B3. [provided by RefSeq, Jul 2008]., [RefSeq]; Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]; His study provides important reference value when narrowing down the number of pathogenic CRYBA4 nsSNPs and studying the pathogenesis of congenital cataracts. By using this method, we can easily find 44 high-risk pathogenic nsSNPs out of 157 CRYBA4 nsSNPs Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 11,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VB22;Q6ICE4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005212 structural constituent of eye lens",
        "go_cellular_component": "",
        "go_biological_process": "GO:0007601 visual perception;GO:0043010 camera-type eye development;GO:0002088 lens development in camera-type eye",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "P53673-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P42685-1",
        "uniprot_id": "FRK_HUMAN",
        "mass": 58254.0,
        "length": 505,
        "protein_name": "Tyrosine-protein kinase FRK",
        "gene_name": "FRK",
        "organism": "Human",
        "refseq_name": "tyrosine-protein kinase FRK",
        "refseq_ac": "NP_002022",
        "gene_names_uniprotkb": "FRK; PTK5; RAK",
        "gene_names_refseq": "FRK; GTK; PTK5; RAK",
        "protein_names_uniprotkb": "Tyrosine-protein kinase FRK; 2.7.10.2; FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5",
        "protein_names_refseq": "PTK5 protein tyrosine kinase 5; fyn-related kinase; nuclear tyrosine protein kinase RAK; protein-tyrosine kinase 5; tyrosine-protein kinase FRK",
        "tax_id": 9606,
        "disease": "intestinal cancer (Disease Ontology:DOID:10155); Goldenhar syndrome (Disease Ontology:DOID:2907); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:2444);  (R-HSA-6798695);  (R-HSA-8948751)",
        "pathway_count": 3,
        "publication_count": 42,
        "publication_id_list": "11035045;12297295;12569567;15186217;15951569;17016520;17218260;17344846;17389395;18083107;18691976;19345329;19473982;19652529;19729658;21209280;21532586;22427670;23419514;23650620;24270891;24275569;24367090;25547115;26183061;26280536;29242379;29348886;31844290;32157095;33277858;34357683;35051231;35494241;35723276;36070195;36284347;7510261;7664264;7696183;8099900;8692836",
        "class_list": "",
        "function": "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase, [RefSeq, PubMed]; FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1., [RefSeq, PubMed]; GATA6 activated long non-coding RNA PCAT1 maintains stemness of non-small cell lung cancer by mediating FRK., [RefSeq, PubMed]; Hemifacial microsomia is linked to a rare homozygous variant V162I in FRK and validated in zebrafish., [RefSeq, PubMed]; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor., [UniProtKB, PubMed]; The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 10,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DY49;Q13128;Q9NTR5",
        "ec_number_list": "1.8.3.2;4.6.1.19;3.2.1.24;2.7.1.35;2.7.12.2;2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;1.6.2.2;3.4.21.-;3.2.1.51;3.5.3.1;1.11.2.2;3.2.1.-;3.2.1.22;3.4.23.5;3.4.21.4;3.2.1.52;3.2.1.31;3.4.21.37;3.4.21.20;2.3.1.16;2.3.1.9;2.3.1.155;4.6.1.18;3.4.16.5;3.4.16.-;2.4.1.1;3.1.27.-;2.7.1.40;3.1.6.8;3.1.6.14;3.1.6.12;3.2.1.23;1.4.3.22;1.4.3.-;1.1.1.205;3.5.1.26;3.4.24.34;3.4.21.76;2.7.11.24;3.1.3.48;1.11.1.27;3.1.1.4;2.3.1.23;3.1.6.4;2.7.1.32;2.7.1.82;2.7.10.4;3.1.21.-;3.6.1.-;3.6.5.2;2.3.3.8;3.4.14.1;3.6.4.6;3.1.3.67;3.1.3.-;3.1.3.16;3.2.1.17;2.7.11.13;3.2.1.14;2.7.11.23;2.3.2.5;6.3.4.21;1.8.4.-;5.3.4.1;3.6.1.6;3.4.19.9;3.2.1.18;1.6.5.5;5.3.99.3;3.5.1.3;3.5.4.4;3.4.18.1;3.4.14.2;3.2.1.166;3.5.3.15",
        "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "P42685-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43464-1",
        "uniprot_id": "HTRA2_HUMAN",
        "mass": 48841.0,
        "length": 458,
        "protein_name": "Serine protease HTRA2, mitochondrial",
        "gene_name": "HTRA2",
        "organism": "Human",
        "refseq_name": "serine protease HTRA2, mitochondrial isoform 3 preproprotein",
        "refseq_ac": "NP_001308656",
        "gene_names_uniprotkb": "HTRA2; OMI; PRSS25",
        "gene_names_refseq": "HTRA2; MGCA8; OMI; PARK13; PRSS25",
        "protein_names_uniprotkb": "Serine protease HTRA2, mitochondrial; 3.4.21.108; High temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; Serine protease 25; Serine proteinase OMI",
        "protein_names_refseq": "HtrA-like serine protease; Omi stress-regulated endoprotease; epididymis secretory sperm binding protein; high temperature requirement protein A2; protease, serine, 25; serine protease 25; serine protease HTRA2, mitochondrial isoform 3 preproprotein; serine protease HTRA2, mitochondrial; serine proteinase OMI",
        "tax_id": 9606,
        "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); 3-methylglutaconic aciduria type 8 (Disease Ontology:DOID:0070000); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); asphyxia neonatorum (Disease Ontology:DOID:11088); cryptorchidism (Disease Ontology:DOID:11383); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); ovarian cancer (Disease Ontology:DOID:2394); middle cerebral artery infarction (Disease Ontology:DOID:3525); colorectal cancer (Disease Ontology:DOID:9256); Parkinson disease 13, autosomal dominant, susceptibility to (MONDO:MONDO:0012466)",
        "pathway": " (hsa:27429);  (R-HSA-9837999);  (R-HSA-9841251)",
        "pathway_count": 3,
        "publication_count": 97,
        "publication_id_list": "10644717;10873535;10971580;10995577;11139588;11237011;11583623;11923310;11967569;12198491;14605674;14623864;15200957;15522782;15870080;15961413;16115876;17101804;17297443;17311912;17579211;17906618;18364387;18401856;18566446;19502560;19841671;21701498;22262461;22710082;23201127;23479728;23665396;23931759;24315374;24520911;25418920;25422467;25576301;26504172;26923599;26992070;27208207;27426517;27496948;27535533;27642048;27696117;27825081;27920218;28218747;28228285;28377575;28396416;28832583;29242379;29301859;29331515;29393594;29557506;29632046;29632711;29932645;30120231;30315122;31217245;31327635;31530632;31695197;31844290;31848261;32157095;32161166;32302062;32350084;32387766;32983136;33141586;33257573;33298915;33592498;33691108;33912179;34357683;34704252;34943861;35051231;35154160;35251023;35870450;36629048;36758104;36758105;38555279;38816423;7623837;8455624",
        "class_list": "",
        "function": "Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Protease activity of Omi/HtrA2 promotes caspase activation through multiple pathways, [RefSeq, PubMed]; Seems to be proteolytically inactive., [UniProtKB, PubMed]; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Structural basis of substrate recognition and allosteric activation of the proapoptotic mitochondrial HtrA2 protease. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 16,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9HBZ4;Q9P0Y3;Q9P0Y4",
        "ec_number_list": "3.4.21.108",
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0051082 unfolded protein binding;GO:0008233 peptidase activity;GO:1990948 ubiquitin ligase inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol",
        "go_biological_process": "GO:0006508 proteolysis;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0051402 neuron apoptotic process;GO:0071300 cellular response to retinoic acid",
        "synthesized_glycan_count": 0,
        "hit_score": 9.8,
        "record_id": "O43464-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P50221-1",
        "uniprot_id": "MEOX1_HUMAN",
        "mass": 27997.0,
        "length": 254,
        "protein_name": "Homeobox protein MOX-1",
        "gene_name": "MEOX1",
        "organism": "Human",
        "refseq_name": "homeobox protein MOX-1 isoform 3",
        "refseq_ac": "NP_001035091",
        "gene_names_uniprotkb": "MEOX1; MOX1",
        "gene_names_refseq": "KFS2; MEOX1; MOX1",
        "protein_names_uniprotkb": "Homeobox protein MOX-1; Mesenchyme homeobox 1",
        "protein_names_refseq": "homeobox protein MOX-1 isoform 3; homeobox protein MOX-1",
        "tax_id": 9606,
        "disease": "Klippel-Feil syndrome 2 (Disease Ontology:DOID:0080590); Klippel-Feil syndrome (Disease Ontology:DOID:10426)",
        "pathway": " (hsa:4222)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "23290072;24073994;28514659;29242379;30429286;31154438;31844290;33912179;34229994;34552174;34837450;35580925;37217939;37559728;38486335;7987315",
        "class_list": "",
        "function": "Characterization of the proteome and metabolome of human liver sinusoidal endothelial-like cells derived from induced pluripotent stem cells., [RefSeq, PubMed]; Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of the novel FOXP3-dependent Treg cell transcription factor MEOX1 by high-dimensional analysis of human CD4[+] T cells. Publication Status: Online-Only, [RefSeq, PubMed]; MEOX1 suppresses the progression of lung cancer cells by inhibiting the cell-cycle checkpoint gene CCNB1., [RefSeq, PubMed]; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]; Unraveling the molecular mechanisms of lymph node metastasis in ovarian cancer: focus on MEOX1. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K524;A8MWF9;Q15069",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0060218 hematopoietic stem cell differentiation;GO:0061053 somite development;GO:0061056 sclerotome development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "P50221-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P17152-1",
        "uniprot_id": "TMM11_HUMAN",
        "mass": 21541.0,
        "length": 192,
        "protein_name": "Transmembrane protein 11, mitochondrial",
        "gene_name": "TMEM11",
        "organism": "Human",
        "refseq_name": "transmembrane protein 11, mitochondrial",
        "refseq_ac": "NP_003867",
        "gene_names_uniprotkb": "TMEM11; C17orf35; PM1",
        "gene_names_refseq": "C17orf35; PM1; PMI; TMEM11",
        "protein_names_uniprotkb": "Transmembrane protein 11, mitochondrial; Protein PM1; Protein PMI",
        "protein_names_refseq": "putative receptor protein; transmembrane protein 11, mitochondrial",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8834);  (R-HSA-8949613)",
        "pathway_count": 2,
        "publication_count": 41,
        "publication_id_list": "17121862;17510655;17624330;18323778;20833715;20877624;2110658;21274005;21836051;22114354;22252321;22864911;24098383;24687277;24715725;25285856;25418920;25764979;25781180;25997101;26416881;26477565;26530328;26968360;26992070;27479602;27485409;27623147;28218747;28514659;29242379;29437277;29769354;30315122;31844290;32157095;32161166;33717175;33912179;35580925;36795401",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in mitochondrial morphogenesis., [UniProtKB, PubMed]; Study demonstrates that the Drosophila PMI gene and its human orthologue TMEM11 encode mitochondrial inner-membrane proteins that regulate mitochondrial morphogenesis, [RefSeq, PubMed]; The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53YB2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007005 mitochondrion organization;GO:0007007 inner mitochondrial membrane organization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "P17152-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HD64-2",
        "uniprot_id": "XAGE1_HUMAN",
        "mass": 9078.0,
        "length": 81,
        "protein_name": "X antigen family member 1",
        "gene_name": "XAGE1A; XAGE1B",
        "organism": "Human",
        "refseq_name": "X antigen family member 1 isoform a",
        "refseq_ac": "NP_001091063",
        "gene_names_uniprotkb": "XAGE1A; XAGE1B; GAGED2; XAGE1C; XAGE1D; XAGE1E; XAGE1",
        "gene_names_refseq": "CT12.1A; CT12.1B; CT12.1; CTP9; GAGED2; XAGE-1; XAGE1A; XAGE1B; XAGE1",
        "protein_names_uniprotkb": "X antigen family member 1; CT12.1; Cancer/testis antigen 12.1; G antigen family D member 2; XAGE-1",
        "protein_names_refseq": "G antigen family D member 2; G antigen, family D, 2; X antigen family member 1 isoform a; X antigen family member 1B; X antigen family member 1; cancer/testis antigen 12.1; cancer/testis antigen family 12, member 1a; cancer/testis antigen family 12, member 1b; cancer/testis associated protein; protein XAGE-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:653067);  (hsa:653220)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "10987281;11992404;12479262;17335148;23186163;27600516;32157095;32387766;32938616;34600138;35580925",
        "class_list": "",
        "function": "Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse in Childhood Acute Myeloid Leukemia., [RefSeq, PubMed]; This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJ94;Q5JPN8;Q5JPP0;Q5JPP3;Q8WWG5;Q8WWG6;Q969J6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9HD64-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P56545-1",
        "uniprot_id": "CTBP2_HUMAN",
        "mass": 48945.0,
        "length": 445,
        "protein_name": "C-terminal-binding protein 2",
        "gene_name": "CTBP2",
        "organism": "Human",
        "refseq_name": "C-terminal-binding protein 2 isoform 1",
        "refseq_ac": "NP_001077383",
        "gene_names_uniprotkb": "CTBP2",
        "gene_names_refseq": "CTBP2",
        "protein_names_uniprotkb": "C-terminal-binding protein 2; CtBP2",
        "protein_names_refseq": "C-terminal-binding protein 2 isoform 1; ribeye",
        "tax_id": 9606,
        "disease": "alcohol use disorder (Disease Ontology:DOID:1574); primary ovarian insufficiency (Disease Ontology:DOID:5426)",
        "pathway": " (hsa:1488);  (R-HSA-4641265);  (R-HSA-5339700);  (R-HSA-9764725)",
        "pathway_count": 4,
        "publication_count": 102,
        "publication_id_list": "10375506;10485457;10485845;10559189;10597289;10655587;10831834;10919662;11163272;11237011;11266540;11290324;11912130;11934263;12700765;12711682;15060175;15121853;15187083;15525529;15542832;15768032;16547505;16702210;17130829;18621708;18669648;18721877;19460168;20068231;20405012;20418909;20871592;22158034;23256519;23466526;23747199;24129315;24275569;24715725;25576301;25728771;25892735;26212009;26992070;27600516;28855257;29485866;29493099;29557506;29729076;29786170;30898548;31844290;32119511;32157095;32357974;32387766;32488085;32897882;32938616;33214551;33537174;33592498;33608512;33968037;33981976;34019948;34087483;34171305;34405274;34509645;34725712;34932366;35008676;35051231;35138000;35251023;35292107;35561310;35580925;35851744;36010968;36215666;36284347;37557182;37643007;37938771;38457926;38665916;38748792;39531497;39534244;39894887;7479821;8365415;8955148;9479502;9751710;9783587;9819412;9887105",
        "class_list": "",
        "function": "C-terminal binding protein 2 is a novel tumor suppressor targeting the MYC-IRF4 axis in multiple myeloma., [RefSeq, PubMed]; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity)., [UniProtKB]; Isoform 2 probably acts as a scaffold for specialized synapses., [UniProtKB]; Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic beta cell function., [RefSeq, PubMed]; Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2., [RefSeq, PubMed]; The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head and neck squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2X5;D3DRF5;O43449;Q5SQP7;Q69YI3;Q86SV0;Q8IY44;Q9H2T8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity;GO:0051287 NAD binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0045202 synapse;GO:0017053 transcription repressor complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "P56545-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96EA4-1",
        "uniprot_id": "SPDLY_HUMAN",
        "mass": 70172.0,
        "length": 605,
        "protein_name": "Protein Spindly",
        "gene_name": "SPDL1",
        "organism": "Human",
        "refseq_name": "protein Spindly isoform b",
        "refseq_ac": "NP_001316570",
        "gene_names_uniprotkb": "SPDL1; CCDC99",
        "gene_names_refseq": "CCDC99; SPDL1",
        "protein_names_uniprotkb": "Protein Spindly; Arsenite-related gene 1 protein; Coiled-coil domain-containing protein 99; Rhabdomyosarcoma antigen MU-RMS-40.4A; Spindle apparatus coiled-coil domain-containing protein 1; hSpindly",
        "protein_names_refseq": "arsenite-related gene 1 protein; coiled-coil domain-containing protein 99; protein Spindly isoform b; protein Spindly; rhabdomyosarcoma antigen MU-RMS-40.4A; rrhabdomyosarcoma antigen protein MU-RMS-40.4A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54908);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5663220);  (R-HSA-68877);  (R-HSA-9648025)",
        "pathway_count": 8,
        "publication_count": 144,
        "publication_id_list": "10411507;10600384;10678165;10958683;11081627;11181178;11237011;11371342;11509732;11535616;11804586;12006501;12194817;12429848;12577064;12679384;12732141;12805219;12852857;14730319;15006353;15085137;15339662;15507212;15723797;15737063;15864301;15866170;15944396;16292343;16439214;16541025;16622419;16622420;16682347;16890222;16943183;17030981;17081983;17112726;17113138;17129783;17196341;17198702;17287340;1737036;17525332;17576797;17924679;18001770;18097444;18716626;18923426;19350017;19468067;19696148;19815554;19965387;20030946;20068231;20101212;20427577;20439434;20591975;20934997;21111234;21148482;21397845;21576392;21868368;21878504;21987589;22094460;22275430;22608513;22790947;22885700;23186163;23222643;23481700;23801653;24714562;24914801;25035494;25418920;25576301;25740311;25789526;25808490;25825516;25880248;25892735;26154972;26375851;26992070;27600516;28514659;28832583;28834231;28904123;29242379;29331515;29437277;29493099;29508533;30258100;30315122;30429286;30779550;31217245;31409757;31690663;31844290;32157095;32357974;32387766;32502341;32897882;32938616;32983136;33298915;33392160;33543222;33592498;33633747;33691108;33717175;33758299;33912179;33936100;33968037;33981976;34171305;34260926;34932366;35051231;35093072;35580925;36010968;36284347;36581221;9649308;9649503;9892021",
        "class_list": "",
        "function": "Dynein-mediated removal of Spindly from microtubule-attached kinetochores, rather than poleward transport per se, is the critical reaction in checkpoint silencing, [RefSeq, PubMed]; Farnesylation of Spindly is essential for its localization, & thus for proper localization of dynein & dynactin, to prometaphase kinetochores. Both Spindly and CENP-E farnesylation are required for efficient chromosome congression, [RefSeq, PubMed]; HSpindly is farnesylated in vivo and farnesylation is essential for its interaction with the RZZ complex and hence Kinetochore localization., [RefSeq, PubMed]; Identification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Required for the localization of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Plays a role in cell migration (PubMed:30258100)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed]; SPDL1 knockdown in human CRC cells significantly increased invasion and migration of tumor cells.  Lower SPDL1 expression levels are significantly associated with reduced survival in CRC patients. SPDL1 depletion in human CRC cells significantly increases tumor development in xenograft assays. SPDL1 is a human CRC tumor-suppressor genes that acts downstream of MRTFB to regulate CRC growth and survival., [RefSeq, PubMed]; Spindly is not only required for kinetochore localization of dynein but is a functional component of a mechanism that couples dynein-dependent poleward movement of chromosomes to their efficient attachment to microtubules., [RefSeq, PubMed]; This gene encodes a coiled-coil domain-containing protein that functions in mitotic spindle formation and chromosome segregation. The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins, and in mitotic checkpoint signaling. [provided by RefSeq, Jul 2016]., [RefSeq]; [Expression and clinical significance of Spindly and Bub3 in oral squamous cell carcinoma]., [RefSeq, PubMed]; [hSpindly] Localization of human Spindly (hSpindly) to kinetochores is controlled by the Rod/Zw10/Zwilch (RZZ) complex and Aurora B., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E393;C9JS47;Q8TEC8;Q9HD44;Q9NX97",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0043515 kinetochore binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0000940 outer kinetochore",
        "go_biological_process": "GO:0016477 cell migration;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0007080 mitotic metaphase chromosome alignment;GO:0000132 establishment of mitotic spindle orientation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.5,
        "record_id": "Q96EA4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96LK0-1",
        "uniprot_id": "CEP19_HUMAN",
        "mass": 19166.0,
        "length": 163,
        "protein_name": "Centrosomal protein of 19 kDa",
        "gene_name": "CEP19",
        "organism": "Human",
        "refseq_name": "centrosomal protein of 19 kDa isoform 1",
        "refseq_ac": "NP_001366398",
        "gene_names_uniprotkb": "CEP19; C3orf34; HSD5",
        "gene_names_refseq": "C3orf34; CEP19; MOSPGF",
        "protein_names_uniprotkb": "Centrosomal protein of 19 kDa; Cep19",
        "protein_names_refseq": "centrosomal protein 19kDa; centrosomal protein of 19 kDa isoform 1",
        "tax_id": 9606,
        "disease": "obesity due to CEP19 deficiency (MONDO:MONDO:0014309)",
        "pathway": " (hsa:84984)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;21399614;24268657;28428259;28625565;28659385;29127258;29242379;29393594;30379171;31844290;32488085;33968037",
        "class_list": "",
        "function": "CEP19 encodes a centrosomal and ciliary protein, as all BBS genes do. Another truncating mutation p.Arg82* has been reported as responsible for morbid obesity in a family; however, in the family we present, not all homozygotes are obese, although some are severely obese., [RefSeq, PubMed]; CEP19 is recruited to the ciliary base by the centriolar CEP350/FOP complex and then specifically captures GTP-bound RABL2B, which is activated via its intrinsic nucleotide exchange., [RefSeq, PubMed]; Loss of the ciliary protein CEP19 in humans and mice causes morbid obesity., [RefSeq, PubMed]; RABL2 binds to CEP19 and the IFT74-IFT81 heterodimer in a mutually exclusive manner., [RefSeq, PubMed]; Required for ciliation (PubMed:28428259, PubMed:28625565, PubMed:28659385). Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28428259, PubMed:28625565). Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes (PubMed:28659385)., [UniProtKB, PubMed, PubMed, PubMed]; The protein encoded by this gene localizes to centrosomes and primary cilia and co-localizes with a marker for the mother centriole. This gene resides in a region of human chromosome 3 that is linked to morbid obesity. A homozygous knockout of the orthologous gene in mouse resulted in mice with morbid obesity, hyperphagy, glucose intolerance, and insulin resistance. Mutations in this gene cause morbid obesity and spermatogenic failure (MOSPGF). This gene has a pseudogene on human chromosome 2. [provided by RefSeq, Apr 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
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        "total_reported_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RA74;Q96I48",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole;GO:0036064 ciliary basal body",
        "go_biological_process": "GO:0060271 cilium assembly;GO:0034454 microtubule anchoring at centrosome;GO:0097712 vesicle targeting, trans-Golgi to periciliary membrane compartment;GO:0030030 cell projection organization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q96LK0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UFF9-1",
        "uniprot_id": "CNOT8_HUMAN",
        "mass": 33540.0,
        "length": 292,
        "protein_name": "CCR4-NOT transcription complex subunit 8",
        "gene_name": "CNOT8",
        "organism": "Human",
        "refseq_name": "CCR4-NOT transcription complex subunit 8 isoform 1",
        "refseq_ac": "NP_001288002",
        "gene_names_uniprotkb": "CNOT8; CALIF; POP2",
        "gene_names_refseq": "CAF1; CALIF; CNOT8; Caf1b; POP2; hCAF1",
        "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 8; 3.1.13.4; CAF1-like protein; CAF2; CALIFp; CCR4-associated factor 8; Caf1b",
        "protein_names_refseq": "CAF1-like protein; CAF2; CALIFp; CCR4-NOT transcription complex subunit 8 isoform 1; CCR4-associated factor 8; PGK promoter directed over production",
        "tax_id": 9606,
        "disease": "heart disease (Disease Ontology:DOID:114)",
        "pathway": " (hsa:9337);  (R-HSA-429947);  (R-HSA-6804115);  (R-HSA-9820841)",
        "pathway_count": 4,
        "publication_count": 114,
        "publication_id_list": "10036195;10637334;10882133;11136725;11230166;11237011;11283721;11814693;11889047;11896574;12771185;12897130;1355481;14583602;14749774;14968113;15475613;15713436;15769875;16140933;16141059;16160013;16284618;17052452;17146433;17245413;17595167;18337750;18625844;19239894;19276069;19558367;19605561;20065043;20352051;20531387;22252318;23236473;23481700;24366607;25418920;25480299;25576301;25892735;26154972;26375851;26758079;26811146;26929215;26992070;27397612;27846572;27920218;28228285;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29769354;29786170;30315122;30524438;30779550;30833945;31154438;31217245;31222486;31464346;31530632;31844290;31848261;32157095;32265295;32387766;32488085;32502341;32502391;32897882;32938616;32983136;33021411;33141586;33392160;33592498;33691108;33717175;33912179;33968037;33981976;34019948;34087483;34171305;34185709;34509645;34647228;34932366;35051231;35318648;35580925;36010968;36241641;36284347;36581221;37938771;8944033;9099687;9184226;9671765;9712883",
        "class_list": "",
        "function": "A network-based variable selection approach for identification of modules and biomarker genes associated with end-stage kidney disease., [RefSeq, PubMed]; Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma., [RefSeq, PubMed]; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "predicted_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0AZS3;B2RAR8;B7Z8R1;D3DQI8;O95709;Q7Z521;Q9H6Y1",
        "ec_number_list": "2.3.2.27;3.6.4.13;3.1.13.4",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0030014 CCR4-NOT complex;GO:0030015 CCR4-NOT core complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0008284 positive regulation of cell population proliferation;GO:0035279 miRNA-mediated gene silencing by mRNA destabilization;GO:0061014 positive regulation of mRNA catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "Q9UFF9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09467-1",
        "uniprot_id": "F16P1_HUMAN",
        "mass": 36842.0,
        "length": 338,
        "protein_name": "Fructose-1,6-bisphosphatase 1",
        "gene_name": "FBP1",
        "organism": "Human",
        "refseq_name": "fructose-1,6-bisphosphatase 1",
        "refseq_ac": "NP_000498",
        "gene_names_uniprotkb": "FBP1; FBP",
        "gene_names_refseq": "FBP1; FBP",
        "protein_names_uniprotkb": "Fructose-1,6-bisphosphatase 1; 3.1.3.11; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; FBPase 1; Liver FBPase",
        "protein_names_refseq": "D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; FBPase 1; fructose-1,6-bisphosphatase 1; growth-inhibiting protein 17; liver FBPase",
        "tax_id": 9606,
        "disease": "fructose-1,6-bisphosphatase deficiency (Disease Ontology:DOID:5204)",
        "pathway": " (hsa:2203);  (R-HSA-70263);  (R-HSA-9940951)",
        "pathway_count": 3,
        "publication_count": 101,
        "publication_id_list": "10204490;10222032;10229653;10714828;10970879;10978333;11237011;11506403;11851336;12093795;12126934;12437512;1278465;12965222;14718531;14722102;15710582;16442285;16446092;16497803;17350621;17646674;18337460;183598;18375435;18449899;18613815;18650089;19118303;21949678;22517657;23506893;24275569;24554700;25150861;25593309;25601412;26374642;26992070;27452731;27633282;27732854;28218747;2842796;28904123;29042441;29437277;29557506;29789417;30045876;30134174;3170585;31746185;31844290;3208766;32157095;32162841;32754266;32983136;33043033;33298915;3355497;33968037;35051231;3529090;35580925;36008597;36266488;38049890;38349431;38538923;38834617;38963044;40930100;4827367;5009693;6434534;6771269;7144574;7391027;7558035;7573034;7589895;7717389;7763253;7809062;7969165;8135811;8211187;8382525;8387495;8447317;8571957;8645161;9382095;9428641;9512513;9585002;9657976;9678974;9758626",
        "class_list": "glycogene",
        "function": "Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; FBP1 inhibits NSCLC stemness by promoting ubiquitination of Notch1 intracellular domain and accelerating degradation. Publication Status: Online-Only, [RefSeq, PubMed]; FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation. Publication Status: Online-Only, [RefSeq, PubMed]; Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression. Erratum:[Nat Chem Biol. 2024 Nov;20(11):1547. doi: 10.1038/s41589-024-01623-3. PMID: 38649455], [RefSeq, PubMed]; Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]., [RefSeq]; Fructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3). Erratum:[Arthritis Res Ther. 2023 Dec 28;25(1):250. doi: 10.1186/s13075-023-03247-9. PMID: 38155346] Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of FBP1 expression by KMT5A through TWIST1 methylation is one of the mechanisms leading to chemoresistance in breast cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 2,
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        "reported_phosphosites": 5,
        "reported_mutagensis": 3,
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        "reported_snv": 414,
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        "biomarker_type": "",
        "glycan_count": 1,
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        "secondary_ac_list": "O75571;Q53F94;Q96E46",
        "ec_number_list": "3.1.3.11;3.6.4.-;3.5.1.-;3.5.1.98",
        "go_molecular_function": "GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016208 AMP binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0097403 cellular response to raffinose;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0032869 cellular response to insulin stimulus;GO:0071320 cellular response to cAMP",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "P09467-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UJW0-1",
        "uniprot_id": "DCTN4_HUMAN",
        "mass": 52337.0,
        "length": 460,
        "protein_name": "Dynactin subunit 4",
        "gene_name": "DCTN4",
        "organism": "Human",
        "refseq_name": "dynactin subunit 4 isoform a",
        "refseq_ac": "NP_001129115",
        "gene_names_uniprotkb": "DCTN4",
        "gene_names_refseq": "DCTN4; DYN4; P62",
        "protein_names_uniprotkb": "Dynactin subunit 4; Dyn4; Dynactin subunit p62",
        "protein_names_refseq": "dynactin 4 (p62); dynactin p62 subunit; dynactin subunit 4 isoform a; dynactin subunit p62",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51164);  (R-HSA-2132295);  (R-HSA-3371497);  (R-HSA-6807878);  (R-HSA-6811436)",
        "pathway_count": 5,
        "publication_count": 299,
        "publication_id_list": "10036229;10052452;10064083;10072072;10318838;10359595;10445031;10480952;10540230;10559959;10559986;10562278;10593899;10631941;10631952;10639150;10671518;10679020;10747884;10748235;10761932;10809954;10903204;10921873;11035033;11080672;11172815;11237011;11285137;11306556;11461920;11483508;11529500;11589254;11684289;11689559;11701661;11703931;11726511;11748249;11751894;11790530;11813165;11853874;12047556;12070132;12078484;12198549;12388752;12401177;12432908;12447383;12634853;12742663;12748383;12781197;12925777;13486053;14654841;14731593;14742712;1493716;15037235;15159550;15381148;15483056;15591061;15616190;15632110;15728195;15749704;15813748;15878873;15911768;15914536;16030262;16181339;16207721;16242130;1631136;16314391;16403413;16554302;16618111;16633337;16723730;1680566;16824007;16912714;16926190;16940185;17142755;17253781;17274799;17283181;17360540;17429068;17451557;17488286;17591767;17760859;17804755;17827179;17927562;17956946;18046453;18086915;18182008;18215318;18243712;18254226;18283113;18292509;18524849;18635947;18641641;18664496;18809720;1898986;19015319;19109418;19164740;19296914;19359544;1956401;19564404;1957170;19631211;19635840;19753100;19758564;20006655;20038533;20072699;20357002;20420828;20427317;20637885;21116285;21158691;21173190;21183720;2121367;21219331;21376746;21441454;21689688;21700222;21796517;21844168;2190094;22011577;22013193;22094269;22130221;22223895;22266222;22304919;22318716;22433123;22562055;22791416;23186163;23333653;23783758;23839779;2391366;24012426;24119662;24694367;24715725;24806965;24891604;25233431;25436559;25453831;25492864;25576301;25892735;26073023;26203193;26313416;26768311;26992070;27462449;27663436;27846572;27862975;28083797;28301631;28510447;28755533;28904123;28919297;29493099;29557506;30197098;30429286;30484775;31110491;31141847;31731497;31826031;31844290;32016915;32157095;32320027;32387766;32448030;32488085;32502341;32544881;32938616;32982970;32983136;33141586;33298915;33392160;33592498;33691108;33717175;33896271;33936100;33968037;33981976;34087483;34171305;34211107;34405274;34509645;35051231;35318648;35580925;36010968;36215666;36241641;36284347;38665916;40914422;6645495;6891012;7481823;7592972;7650016;7667286;7691276;8001155;8046351;8128252;8132710;8134367;8145819;8148318;8157723;8221884;8253837;8282004;8313912;8397411;8415765;8505331;8560673;8620540;8636227;8642258;8687433;8849454;8909537;8939989;8947036;8991093;9030515;9050864;9075930;9114004;9150144;9177194;9202021;9244307;9288971;9311912;9312039;9323141;9380700;9382863;9405360;9464360;9464361;9490716;9497313;9539769;9545226;9606180;9667968;9671725;9671731;9733780;9751720;9990005",
        "class_list": "",
        "function": "ATP7B interaction with p62 is a key component of the copper-induced trafficking pathway that delivers ATP7B to subapical vesicles of hepatocytes for the removal of excess copper into bile, [RefSeq, PubMed]; Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules., [UniProtKB, UniProtKB]; Study on the Prognostic Values of Dynactin Genes in Low-Grade Glioma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "total_reported_o_glycosites": 1,
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        "reported_mutagensis": 12,
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        "biomarker_type": "",
        "glycan_count": 1,
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        "secondary_ac_list": "B3KWW0;D3DQH0;E5RGT5;Q8TAN8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 30.2,
        "record_id": "Q9UJW0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P24864-1",
        "uniprot_id": "CCNE1_HUMAN",
        "mass": 47077.0,
        "length": 410,
        "protein_name": "G1/S-specific cyclin-E1",
        "gene_name": "CCNE1",
        "organism": "Human",
        "refseq_name": "G1/S-specific cyclin-E1 isoform 1",
        "refseq_ac": "NP_001229",
        "gene_names_uniprotkb": "CCNE1; CCNE",
        "gene_names_refseq": "CCNE1; CCNE; pCCNE1",
        "protein_names_uniprotkb": "G1/S-specific cyclin-E1",
        "protein_names_refseq": "G1/S-specific cyclin-E1 isoform 1; G1/S-specific cyclin-E1",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); breast adenocarcinoma (Disease Ontology:DOID:3458); liver cancer (Disease Ontology:DOID:3571); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)",
        "pathway": " (hsa:898);  (R-HSA-1538133);  (R-HSA-187577);  (R-HSA-2559586);  (R-HSA-390471);  (R-HSA-6804116);  (R-HSA-69017);  (R-HSA-69200);  (R-HSA-69202);  (R-HSA-69205);  (R-HSA-69231);  (R-HSA-69563);  (R-HSA-8849470);  (R-HSA-9661069);  (R-HSA-9706019)",
        "pathway_count": 15,
        "publication_count": 247,
        "publication_id_list": "10037601;10207050;10228158;10323868;10339564;10375532;10385618;10454565;10454584;10499802;10559916;10597240;10669743;10692433;10831586;10891498;10995389;11032757;11046155;11073976;11157749;11231573;11231585;11237011;11416152;11454856;11585773;11719808;11812999;11884610;11907280;11959842;11988738;12393752;12435635;12444543;12502735;12556884;12692263;12782299;1423597;14517297;14532133;14536078;14580351;14597415;14633988;14990995;15014447;15064416;15133492;15178429;15199159;15369670;15458641;15469821;15510213;15510216;15579463;15655109;15660127;15722552;15790808;16141325;16166375;16195327;16209941;16262255;16782892;16858402;17092340;17254966;17254967;17434132;17525332;17694070;17719541;17908796;17923702;18194653;18202719;1826560;1828392;1828393;1828394;1833066;1833068;18414028;18438399;18669648;18691976;18710949;18719096;18775504;18827403;19011634;19019082;19075005;19369195;19458076;19487459;19490898;19561641;19664994;19783983;20107323;20663872;20817677;20843055;20952511;21098288;21423214;21498570;21540187;21715330;21952639;21995946;22172947;22245496;22424782;22558078;22709582;22802528;22802529;23007395;23064264;23186163;2342578;23481700;23622515;23737759;23747015;2392154;24145166;24515438;24714562;24715725;24756126;24876129;25240135;25342745;25467444;25505266;25645385;25733683;25880248;26215701;26992070;27452520;27600516;27846572;27893789;27920218;28228285;28649982;28832583;28904123;29242379;29493099;29508533;29632046;29760377;30315122;30711375;30779550;30833945;31154438;31291378;31543423;31844290;32157095;32357974;32387766;32502341;32897882;32938616;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33936100;33968037;34171305;34185709;34405274;34509645;34932366;35051231;35561310;35580925;36010968;36241641;38625790;38717153;38763409;7623816;7629134;7739542;7743995;7797074;7799941;7929342;7954814;8114698;8114739;8139570;8207080;8242751;8242752;8246996;8288595;8336704;8413249;8497257;8618861;8649818;8700224;8833152;8861947;8943353;9020173;9042862;9106657;9144196;9190208;9199292;9325318;9342358;9447971;9448290;9482921;9508775;9520412;9632134;9662327;9724731;9733514;9733515;9778043;9780002;9819444;9840943;9843217;9891042",
        "class_list": "",
        "function": "Essential for the control of the cell cycle at the G1/S (start) transition., [UniProtKB, PubMed]; Hsa-miR-CHA2, a novel microRNA, exhibits anticancer effects by suppressing cyclin E1 in human non-small cell lung cancer cells., [RefSeq, PubMed]; Molecular Landscape and Clinical Implication of CCNE1-amplified Esophagogastric Cancer., [RefSeq, PubMed]; RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells., [RefSeq, PubMed]; The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 15,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 12,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K684;Q14091;Q8NFG1;Q92501;Q9UD21",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0016301 kinase activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005815 microtubule organizing center",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:1902462 positive regulation of mesenchymal stem cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 24.8,
        "record_id": "P24864-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9GZX5-1",
        "uniprot_id": "ZN350_HUMAN",
        "mass": 60011.0,
        "length": 532,
        "protein_name": "Zinc finger protein 350",
        "gene_name": "ZNF350",
        "organism": "Human",
        "refseq_name": "zinc finger protein 350",
        "refseq_ac": "NP_067645",
        "gene_names_uniprotkb": "ZNF350; ZBRK1",
        "gene_names_refseq": "ZBRK1; ZFQR; ZNF350",
        "protein_names_uniprotkb": "Zinc finger protein 350; KRAB zinc finger protein ZFQR; Zinc finger and BRCA1-interacting protein with a KRAB domain 1; Zinc finger protein ZBRK1",
        "protein_names_refseq": "KRAB zinc finger protein ZFQR; zinc finger and BRCA1-interacting protein with a KRAB domain 1; zinc finger protein 350; zinc finger protein ZBRK1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:59348);  (R-HSA-212436);  (R-HSA-3899300)",
        "pathway_count": 3,
        "publication_count": 73,
        "publication_id_list": "10235266;10330177;11090615;11161714;11237011;11395415;11477070;11842083;12150977;12529333;12679040;12718889;12872252;14517299;14519192;14660588;14755250;15175151;15766567;15896744;15958389;15976810;16098147;16485136;16606702;16719718;16757475;17079232;17081986;17298944;17369852;17535915;17557904;17803295;17942393;18082607;18211901;18339323;18488044;19240082;19596686;19615980;19664994;19995069;20098713;20176810;20676127;21338522;21527249;2163759;22467880;22713328;23404503;23665872;23673342;25114211;25218447;25800734;28832583;29291027;31844290;32157095;33407485;34087483;34685484;35051231;35580925;36356714;38049396;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "Correlation between ZBRK1/ZNF350 gene polymorphism and breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; HECW1 induces NCOA4-regulated ferroptosis in glioma through the ubiquitination and degradation of ZNF350. Publication Status: Online-Only, [RefSeq, PubMed]; IRF1/ZNF350/GPX4-mediated ferroptosis of renal tubular epithelial cells promote chronic renal allograft interstitial fibrosis., [RefSeq, PubMed]; Role of the Transcriptional Repressor Zinc Finger with KRAB and SCAN Domains 3 (ZKSCAN3) in Retinal Pigment Epithelial Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3., [UniProtKB, PubMed]; ZBRK1 is a novel target for DNA damage-induced degradation, [RefSeq, PubMed]; ZBRK1 mutation found in BRCA1 and BRCA2 mutation negative probands with breast or ovarian cancer., [RefSeq, PubMed]; ZBRK1 zinc fingers have dual roles in sequence-specific DNA-binding and BRCA1-dependent transcriptional repression, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96G73;Q9HAQ4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0016604 nuclear body;GO:0016363 nuclear matrix",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "Q9GZX5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5VW32-1",
        "uniprot_id": "BROX_HUMAN",
        "mass": 46476.0,
        "length": 411,
        "protein_name": "BRO1 domain-containing protein BROX",
        "gene_name": "BROX",
        "organism": "Human",
        "refseq_name": "BRO1 domain-containing protein BROX isoform b",
        "refseq_ac": "NP_001275508",
        "gene_names_uniprotkb": "BROX; BROFTI; C1orf58",
        "gene_names_refseq": "BROX; C1orf58",
        "protein_names_uniprotkb": "BRO1 domain-containing protein BROX; BRO1 domain- and CAAX motif-containing protein",
        "protein_names_refseq": "BRO1 domain-containing protein BROX isoform b; BRO1 domain-containing protein BROX",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:148362)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "11237011;16408927;17411337;18190528;19608861;21889351;22162750;22484091;25576301;26853435;26866605;26992070;28467828;28832583;28904123;29242379;29314611;29557506;29632711;29786170;30429286;30484775;30573663;30779550;31154438;31844290;31848261;31998317;32157095;32350084;32357974;32385852;32387766;32938616;32983136;33592498;33912179;33968037;34019948;34087483;34357683;34433824;34509645;34818527;34932366;35051231;35251023;35580925;36010968;36215666;38665916",
        "class_list": "",
        "function": "BROX haploinsufficiency in familial nonmedullary thyroid cancer., [RefSeq, PubMed]; Homologous domain of human Bro1 domain-containing proteins, Alix and Brox, binds CHMP4B but not STAM2, despite their high structural similarity Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear envelope-associated factor that is involved in the nuclear envelope ruptures during interphase (NERDI) repair, where it is locally recruited by CHMP5 and reduces cytoskeletal stress through its action on SYN2 to help reseal the ruptured membrane., [UniProtKB, PubMed]; Results revealed that Strep-Brox(WT) exhibited accumulation in the perinuclear area suggested physiological significance of farnesylation of Brox in its subcellular distribution and efficient interaction with CHMP4s in vivo., [RefSeq, PubMed]; Structural analysis of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z9G5;Q96MG1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0007084 mitotic nuclear membrane reassembly",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q5VW32-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99622-1",
        "uniprot_id": "C10_HUMAN",
        "mass": 13178.0,
        "length": 126,
        "protein_name": "Protein C10",
        "gene_name": "C12orf57",
        "organism": "Human",
        "refseq_name": "protein C10 isoform 1",
        "refseq_ac": "NP_001288763",
        "gene_names_uniprotkb": "C12orf57; C10",
        "gene_names_refseq": "C10; C12orf57; GRCC10",
        "protein_names_uniprotkb": "Protein C10",
        "protein_names_refseq": "gene rich cluster C10; likely ortholog of mouse gene rich cluster, C10; protein C10 isoform 1; protein C10",
        "tax_id": 9606,
        "disease": "Temtamy syndrome (Disease Ontology:DOID:0111621)",
        "pathway": " (hsa:113246)",
        "pathway_count": 1,
        "publication_count": 67,
        "publication_id_list": "11237011;19204726;21209280;22223895;22645359;23453665;23453666;23633300;24714562;24715725;24798461;25576301;26154972;26992070;27862975;27920218;28228285;28514659;28649982;28832583;28834231;28904123;29242379;29331515;29508533;29557506;29632711;30410026;30429286;30524438;30779550;30833945;31154438;31217245;31530632;31844290;31848261;31937595;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34357683;34509645;35051231;35318648;35561310;35580925;36241641;36284347;37938771;9074930",
        "class_list": "",
        "function": "Exome sequencing identifies compound heterozygous mutations in C12orf57 in two siblings with severe intellectual disability, hypoplasia of the corpus callosum, chorioretinal coloboma, and intractable seizures. Review article, [RefSeq, PubMed]; In brain, may be required for corpus callosum development., [UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene is ubiquitously expressed in human tissues. It is required for development of the human corpus callosum. Mutations in this gene are associated with Temtamy syndrome (TEMTYS). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "predicted_c_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
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        "reported_snv": 2,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4Q6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0050890 cognition;GO:0009791 post-embryonic development;GO:0048593 camera-type eye morphogenesis;GO:0014819 regulation of skeletal muscle contraction;GO:0021540 corpus callosum morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q99622-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75330-1",
        "uniprot_id": "HMMR_HUMAN",
        "mass": 84100.0,
        "length": 724,
        "protein_name": "Hyaluronan mediated motility receptor",
        "gene_name": "HMMR",
        "organism": "Human",
        "refseq_name": "hyaluronan mediated motility receptor isoform a",
        "refseq_ac": "NP_001136028",
        "gene_names_uniprotkb": "HMMR; IHABP; RHAMM",
        "gene_names_refseq": "CD168; HMMR; IHABP; RHAMM",
        "protein_names_uniprotkb": "Hyaluronan mediated motility receptor; Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility",
        "protein_names_refseq": "hyaluronan mediated motility receptor isoform a; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motility",
        "tax_id": 9606,
        "disease": "breast cancer (Disease Ontology:DOID:1612)",
        "pathway": " (hsa:3161);  (R-HSA-2142845);  (R-HSA-2160916);  (R-HSA-8854518)",
        "pathway_count": 4,
        "publication_count": 137,
        "publication_id_list": "10037799;11237011;11350981;11568288;1426053;14514708;14580337;15035633;15090545;15208308;15498487;15503855;15510212;15705883;16104017;16565220;17009043;1703543;17050540;17145755;17540771;18434317;18452278;18619726;18669648;19007248;19413330;19691289;20068231;21347367;22094468;22110403;22424782;22544926;22666460;22898188;22965910;23186163;23301498;23481700;23509262;24154794;24366607;24714562;24715725;24847057;25418920;25532896;25576301;25645385;25802875;25880248;26154972;26728094;26768311;26992070;27600516;27846572;27893789;27920218;28218747;28228285;28832583;28834231;28904123;28993511;29242379;29493099;29508533;29557506;2971395;29786170;29789417;30315122;30524438;30779550;30833945;31154438;31217245;31291378;31429579;31530632;31575892;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;33091337;33141586;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34405274;34509645;34561969;3468507;34932366;35051231;35494241;35580925;35799423;36010968;36215666;36241641;36284347;36603370;36945114;37186300;37217939;37673961;38633247;40914422;8282124;8798477;8798544;8890751;8901634;9083017;9601098;9712871",
        "class_list": "glycogene",
        "function": "Coupled scRNA-seq and Bulk-seq reveal the role of HMMR in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; RHAMM marks proliferative subpopulation of human colorectal cancer stem cells., [RefSeq, PubMed]; Receptor for hyaluronan-mediated motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients., [RefSeq, PubMed]; Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity)., [UniProtKB, UniProtKB]; Targeting hyaluronan-mediated motility receptor (HMMR) enhances response to androgen receptor signalling inhibitors in prostate cancer., [RefSeq, PubMed]; The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]., [RefSeq]; Tumor-promoting roles of HMMR in lung adenocarcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 803,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3G2;B4E114;D3DQK9;D3DQL0;E9PCS0;Q32N02;Q92767",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005540 hyaluronic acid binding;GO:0038024 cargo receptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006898 receptor-mediated endocytosis;GO:0030214 hyaluronan catabolic process;GO:1901264 carbohydrate derivative transport",
        "synthesized_glycan_count": 0,
        "hit_score": 14.0,
        "record_id": "O75330-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P13196-1",
        "uniprot_id": "HEM1_HUMAN",
        "mass": 70581.0,
        "length": 640,
        "protein_name": "5-aminolevulinate synthase, non-specific, mitochondrial",
        "gene_name": "ALAS1",
        "organism": "Human",
        "refseq_name": "5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 precursor",
        "refseq_ac": "NP_000679",
        "gene_names_uniprotkb": "ALAS1; ALAS3; ALASH; SW-cl.121",
        "gene_names_refseq": "ALAS-H; ALAS1; ALAS3; ALASH; ALAS; MIG4",
        "protein_names_uniprotkb": "5-aminolevulinate synthase, non-specific, mitochondrial; 2.3.1.37; 5-aminolevulinic acid synthase 1; ALAS-H; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1",
        "protein_names_refseq": "5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 precursor; 5-aminolevulinate synthase, non-specific, mitochondrial; 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; aminolevulinate, delta-, synthase 1; delta-ALA synthase 1; delta-aminolevulinate synthase 1; migration-inducing protein 4",
        "tax_id": 9606,
        "disease": "porphyria (Disease Ontology:DOID:13268); erythropoietic protoporphyria (Disease Ontology:DOID:13270); pulmonary hypertension (Disease Ontology:DOID:6432)",
        "pathway": " (hsa:211);  (R-HSA-189451);  (R-HSA-1989781);  (R-HSA-2151201);  (R-HSA-9837999)",
        "pathway_count": 5,
        "publication_count": 187,
        "publication_id_list": "10412986;10643692;10706561;10713165;10777541;11032836;11032841;11175906;11237011;11267664;11340167;11809803;11923310;12118000;12177166;12198491;12374852;12474143;12505311;12563009;12582161;12745923;12773194;14623864;15067378;15130092;15235026;15522782;15635043;15684387;15863660;15870080;16079181;16079853;16115876;16121195;16176984;16234850;16258391;16380219;16788062;16890199;16908542;16911507;16972786;17031457;17101804;17297443;17437997;17579211;17715127;17923681;17975826;18215119;18343819;18540824;18680753;18719978;18767875;18848529;19001277;19088433;19356719;1939222;19417006;19710929;19841671;19934321;19951946;20110263;20705604;22262461;2263504;22645359;22710082;23201127;23467411;23931759;24196956;24315374;24366607;24520911;24714562;24715725;25418920;25576301;25645385;25880248;26024233;26154972;26504172;26728094;26923599;26992070;27496948;27600516;27642048;27846572;27920218;28063628;28228285;28377575;28396416;28514659;28832583;28834231;28904123;29242379;29301859;29393594;29493099;29508533;29557506;29632046;29786170;29789417;29932645;30120231;30315122;30779550;30833945;31154438;31217245;31327635;31530632;31695197;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32488085;32897882;32938616;32983136;33141586;33199206;33257573;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34561969;34704252;34932366;34943861;35051231;35561310;35580925;35870450;36010968;36215666;36241641;36284347;36581221;36629048;3671094;3805019;38253038;666752;6822570;7354069;7592565;7623837;7629110;7685352;7799916;7892212;8078902;8108407;8159699;8333869;8644733;8647822;8771201;9012850;9177788;9178750;9286700;9748239;9878253",
        "class_list": "",
        "function": "5-Aminolevulinate dehydratase porphyria: Update on hepatic 5-aminolevulinic acid synthase induction and long-term response to hemin., [RefSeq, PubMed]; Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products., [UniProtKB, PubMed, PubMed]; Heme-dependent recognition of 5-aminolevulinate synthase by the human mitochondrial molecular chaperone ClpX., [RefSeq, PubMed]; This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "2.3.3.1;7.1.1.2;3.6.4.10;1.2.1.3;7.1.2.2;4.2.1.2;1.2.4.1;1.8.1.4;5.6.1.7;2.3.1.37;4.98.1.1;1.1.1.38;2.3.1.9;1.2.1.36;1.7.1.-;1.2.1.28;1.1.1.37;5.3.3.8;1.1.1.42;3.1.2.2;1.1.1.41;2.8.3.5;3.5.3.1;1.2.4.2;1.1.1.30;5.3.3.21;2.7.11.2;2.7.11.-;2.3.1.48;3.4.21.92;1.1.1.35;3.6.4.-;2.1.1.319;2.3.1.-;6.2.1.-;6.2.1.4;2.1.1.-;4.2.1.3;3.1.13.1;5.6.2.6;3.6.4.13;2.3.1.41;1.3.8.5",
        "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0003870 5-aminolevulinate synthase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0045471 response to ethanol;GO:0001666 response to hypoxia;GO:0031667 response to nutrient levels;GO:0051591 response to cAMP",
        "synthesized_glycan_count": 0,
        "hit_score": 19.0,
        "record_id": "P13196-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BQG2-1",
        "uniprot_id": "NUD12_HUMAN",
        "mass": 52076.0,
        "length": 462,
        "protein_name": "NAD-capped RNA hydrolase NUDT12",
        "gene_name": "NUDT12",
        "organism": "Human",
        "refseq_name": "NAD-capped RNA hydrolase NUDT12 isoform 2",
        "refseq_ac": "NP_001287670",
        "gene_names_uniprotkb": "NUDT12",
        "gene_names_refseq": "NUDT12",
        "protein_names_uniprotkb": "NAD-capped RNA hydrolase NUDT12; 3.6.1.-; 3.6.1.22; DeNADding enzyme NUDT12; NADH pyrophosphatase NUDT12; Nucleoside diphosphate-linked moiety X motif 12; Nudix motif 12",
        "protein_names_refseq": "NAD-capped RNA hydrolase NUDT12 isoform 2; NAD-capped RNA hydrolase NUDT12; deNADding enzyme NUDT12; nucleoside diphosphate linked moiety X-type motif 12; nucleoside diphosphate-linked moiety X motif 12; nudix (nucleoside diphosphate linked moiety X)-type motif 12; nudix motif 12; peroxisomal NADH pyrophosphatase NUDT12",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83594);  (R-HSA-196807)",
        "pathway_count": 2,
        "publication_count": 89,
        "publication_id_list": "10331643;10613898;11230166;11248244;11594753;11788603;11866528;11991719;12359228;12547821;12574164;12790796;13563527;14516279;14966140;15090606;15137942;15381699;15674325;16118205;1637327;16690024;17402747;17604275;17641676;17868694;17914902;18411268;19531469;20112406;20388704;2129526;21504897;21699903;21933152;21994945;22701565;22822066;23212377;23230272;24717514;24847004;25531177;25576301;26375851;26992070;27600516;27846572;28832583;28834231;29393594;29557506;29632046;29786170;29789417;30315122;30779550;30833945;31101919;31154438;31844290;31848261;31875550;32157095;32161166;32488085;32906142;33087354;33141586;33392160;33537174;33592498;33968037;34087483;34171305;34185709;34932366;35051231;35580925;36010968;36284347;37938771;4349867;8182091;8289818;8527488;8575745;8809081;9473669",
        "class_list": "",
        "function": "Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs., [RefSeq, PubMed]; NUDT12 may act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle., [RefSeq, PubMed]; Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008]., [RefSeq]; The crystal structure of mouse Nudt12 in complex with the deNADding product AMP and three Mg(2+) ions at 1.6 A resolution provides insights into the molecular basis of the deNADding activity in the NAD pyrophosphate., [RefSeq, PubMed]; mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PubMed:31101919, PubMed:31875550). The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:31101919). Preferentially acts on NAD-capped transcripts in response to nutrient stress (PubMed:31101919). Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP (PubMed:12790796). May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (PubMed:12790796). Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KUW2;B4E1W3;Q8TAL7",
        "ec_number_list": "3.6.1.22;3.6.1.18;2.7.7.2;3.6.1.62;3.6.1.64;3.6.1.-;3.1.-.-",
        "go_molecular_function": "GO:0000210 NAD+ diphosphatase activity;GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding;GO:0035529 NADH pyrophosphatase activity;GO:1990174 phosphodiesterase decapping endonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix",
        "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0006402 mRNA catabolic process;GO:0032922 circadian regulation of gene expression;GO:0006742 NADP+ catabolic process;GO:0110155 NAD-cap decapping",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "Q9BQG2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75665-1",
        "uniprot_id": "OFD1_HUMAN",
        "mass": 116671.0,
        "length": 1012,
        "protein_name": "Centriole and centriolar satellite protein OFD1",
        "gene_name": "OFD1",
        "organism": "Human",
        "refseq_name": "centriole and centriolar satellite protein OFD1 isoform 2",
        "refseq_ac": "NP_001317138",
        "gene_names_uniprotkb": "OFD1; CXorf5",
        "gene_names_refseq": "71-7A; CXorf5; JBTS10; OFD1; RP23; SGBS2",
        "protein_names_uniprotkb": "Centriole and centriolar satellite protein OFD1; Oral-facial-digital syndrome 1 protein; Protein 71-7A",
        "protein_names_refseq": "Joubert syndrome type 10; centriole and centriolar satellite protein OFD1 isoform 2; centriole and centriolar satellite protein OFD1; oral-facial-digital syndrome 1 protein; protein 71-7A",
        "tax_id": 9606,
        "disease": "orofaciodigital syndrome I (Disease Ontology:DOID:0060316); Simpson-Golabi-Behmel syndrome type 2 (Disease Ontology:DOID:0080342); retinitis pigmentosa 23 (Disease Ontology:DOID:0110412); Joubert syndrome 10 (Disease Ontology:DOID:0110981); retinitis pigmentosa (Disease Ontology:DOID:10584); retinal degeneration (Disease Ontology:DOID:8466)",
        "pathway": " (hsa:8481);  (R-HSA-2565942);  (R-HSA-380259);  (R-HSA-380270);  (R-HSA-380284);  (R-HSA-380320);  (R-HSA-5610787);  (R-HSA-5620912);  (R-HSA-8854518)",
        "pathway_count": 9,
        "publication_count": 233,
        "publication_id_list": "10966113;11076968;11179005;11237011;11375483;11950863;11956313;12192414;12207013;12221128;12364337;12435627;12595504;12852856;13678582;14580337;14603322;14654843;15087129;15498487;15705883;15930098;16061793;16136078;16229832;16254602;16311594;16339192;16357211;16396903;16397067;16462731;16493421;16707575;16783569;16890155;17027958;17200122;17442700;17553904;17574030;17641202;17646400;17719545;17761535;17762891;17960137;18037885;18327258;18378770;18455992;18477460;18491316;18521620;18566290;18615013;18669648;18694559;18801063;18832070;19000668;19004860;19081074;19196978;19223390;19286674;19365551;19549984;19592253;19651622;19666503;19691289;19767740;19776033;19800048;19877275;19906846;19940019;19948480;19996169;20067783;20068231;20154143;20207148;20230748;20308558;20395968;20399632;20412786;20460306;20558667;20835237;20844016;20889716;20956384;2105456;21209331;21273506;21347367;21406692;21422230;21548880;21565611;21620453;21695114;21725307;21792235;21801010;22007132;22094468;22179047;22231273;22365832;22391300;22433857;22619378;22641346;22653444;23033313;23141531;23141541;23186163;23209152;23253480;23301498;23332756;23348840;23400999;23481700;23530209;23719536;23747070;23769972;23789104;23921553;24053599;24089205;24121310;24231678;24302888;24339784;24366607;24469809;24714562;24715725;24845016;24863049;24917297;24925320;24952464;24982133;24997988;25047611;25313408;25418920;25532896;25576301;25645385;25880248;25892735;26154972;26375851;26477546;26643951;26811146;26992070;27397612;27846572;27920218;28063628;28228285;28832583;28834231;28855257;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30379171;30410026;30429286;30779550;30833945;31217245;31530632;31844290;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33402344;33592498;33691108;33717175;33912179;33934390;33936100;33968037;33981976;34171305;34357683;34509645;34932366;35051231;35154160;35561310;35580925;36010968;36215666;36241641;38139355;38158857;7769006;7790358;8838651;9722947",
        "class_list": "",
        "function": "Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity)., [UniProtKB, PubMed, UniProtKB]; Extraciliary OFD1 Is Involved in Melanocyte Survival through Cell Adhesion to ECM via Paxillin. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is located on the X chromosome and encodes a centrosomal protein. A knockout mouse model has been used to study the effect of mutations in this gene. The mouse gene is also located on the X chromosome, however, unlike the human gene it is not subject to X inactivation. Mutations in this gene are associated with oral-facial-digital syndrome type I and Simpson-Golabi-Behmel syndrome type 2. Many pseudogenes have been identified; a single pseudogene is found on chromosome 5 while as many as fifteen have been found on the Y chromosome. [provided by RefSeq, Aug 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9ZVU5;O75666;Q4VAK4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0043014 alpha-tubulin binding;GO:0043015 gamma-tubulin binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium",
        "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation;GO:0060271 cilium assembly;GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry",
        "synthesized_glycan_count": 0,
        "hit_score": 23.6,
        "record_id": "O75665-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00541-1",
        "uniprot_id": "PESC_HUMAN",
        "mass": 68003.0,
        "length": 588,
        "protein_name": "Pescadillo homolog",
        "gene_name": "PES1",
        "organism": "Human",
        "refseq_name": "pescadillo homolog isoform 2",
        "refseq_ac": "NP_001230154",
        "gene_names_uniprotkb": "PES1",
        "gene_names_refseq": "NOP7; PES1; PES",
        "protein_names_uniprotkb": "Pescadillo homolog",
        "protein_names_refseq": "pescadillo homolog 1, containing BRCT domain; pescadillo homolog isoform 2",
        "tax_id": 9606,
        "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479)",
        "pathway": " (hsa:23481);  (R-HSA-6791226)",
        "pathway_count": 2,
        "publication_count": 135,
        "publication_id_list": "11071894;11237011;11922599;12022229;12068309;12150911;12429849;16037817;16043514;16738141;17189298;17353269;17412707;18065403;18083107;18438418;18477386;18669648;19106111;19332556;19564402;19608861;19691289;19764998;19801658;20038530;20056613;20068231;20531386;20798176;20805244;20819938;21036871;21063389;21097556;22072790;22190735;22195017;22869377;22916032;23439679;23481700;23482395;2388630;24366607;24397554;24424021;24550520;24714562;24715725;25114211;25418920;25525153;25576301;25825154;25892735;25969445;26154972;26237581;26375851;26728094;26811146;26929215;26992070;27600516;27846572;27920218;28063628;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30429286;30484775;30524438;30833945;31154438;31217245;31530632;31718704;31844290;31848261;32157095;32161166;32265295;32357974;32387766;32488085;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34357683;34509645;34561969;34932366;35051231;35083852;35580925;36217758;36241641;36284347;36581221;36775058;37076985;37217939;38665916;40914422;8985183;9482744",
        "class_list": "",
        "function": "Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Overexpression of hepatic pescadillo 1 in obesity induces lipid dysregulation by inhibiting autophagy., [RefSeq, PubMed]; PES1 is a biomarker of head and neck squamous cell carcinoma and is associated with the tumor microenvironment., [RefSeq, PubMed]; Pescadillo might play a role in promoting the proliferation and carcinogenesis of human breast cancer, and thereby might be a potential target for human breast cancer treatment. Erratum:[Cancer Sci. 2021 Nov;112(11):4812. doi: 10.1111/cas.15148. PMID: 34766426], [RefSeq, PubMed]; Pescadillo ribosomal biogenesis factor 1 reduction suppresses tumour growth and renders chemosensitivity of head and neck squamous cell carcinoma., [RefSeq, PubMed]; This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "total_reported_o_glycosites": 1,
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        "reported_phosphosites": 7,
        "reported_mutagensis": 4,
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        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IC29",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0043021 ribonucleoprotein complex binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016020 membrane;GO:0030687 preribosome, large subunit precursor;GO:0005694 chromosome",
        "go_biological_process": "GO:0008283 cell population proliferation;GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0051726 regulation of cell cycle;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)",
        "synthesized_glycan_count": 0,
        "hit_score": 13.8,
        "record_id": "O00541-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P60484-1",
        "uniprot_id": "PTEN_HUMAN",
        "mass": 47166.0,
        "length": 403,
        "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN",
        "gene_name": "PTEN",
        "organism": "Human",
        "refseq_name": "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform PTEN",
        "refseq_ac": "NP_000305",
        "gene_names_uniprotkb": "PTEN; MMAC1; TEP1",
        "gene_names_refseq": "10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; PTENbeta; PTENgama; PTEN; TEP1",
        "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; 3.1.3.-; 3.1.3.16; 3.1.3.48; 3.1.3.67; Inositol polyphosphate 3-phosphatase; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog",
        "protein_names_refseq": "MMAC1 phosphatase and tensin homolog deleted on chromosome 10; PTEN variant PTEN-K267Rfs*9; PTEN variant PTEN-L247*; PTEN variant PTEN-R234Afs*11; PTENepsilon; inositol polyphosphate 3-phosphatase; mitochondrial PTENalpha; mitochondrial phosphatase and tensin protein alpha; mutated in multiple advanced cancers 1; phosphatase and tensin-like protein; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase",
        "tax_id": 9606,
        "disease": "disease of metabolism (Disease Ontology:DOID:0014667); Cowden syndrome 1 (Disease Ontology:DOID:0050657); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); ovarian serous carcinoma (Disease Ontology:DOID:0050933); autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 10q23 deletion syndrome (Disease Ontology:DOID:0060389); cerebral cavernous malformation (Disease Ontology:DOID:0060669); macrocephaly-autism syndrome (Disease Ontology:DOID:0060867); intestinal pseudo-obstruction (Disease Ontology:DOID:0080072); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); retinitis pigmentosa (Disease Ontology:DOID:10584); portal hypertension (Disease Ontology:DOID:10762); urinary bladder cancer (Disease Ontology:DOID:11054); peripheral nervous system neoplasm (Disease Ontology:DOID:1192); leiomyoma (Disease Ontology:DOID:127); persistent fetal circulation syndrome (Disease Ontology:DOID:13042); biliary atresia (Disease Ontology:DOID:13608); endometrial cancer (Disease Ontology:DOID:1380); major depressive disorder (Disease Ontology:DOID:1470); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); hyperinsulinism (Disease Ontology:DOID:2018); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); hemangiopericytoma (Disease Ontology:DOID:264); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); substance-related disorder (Disease Ontology:DOID:303); high grade glioma (Disease Ontology:DOID:3070); angiomyolipoma (Disease Ontology:DOID:3314); bladder squamous cell carcinoma (Disease Ontology:DOID:3742); lung non-small cell carcinoma (Disease Ontology:DOID:3908); follicular thyroid carcinoma (Disease Ontology:DOID:3962); renal cell carcinoma (Disease Ontology:DOID:4450); familial meningioma (Disease Ontology:DOID:4586); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); esophageal cancer (Disease Ontology:DOID:5041); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); Cowden syndrome (Disease Ontology:DOID:6457); hepatocellular carcinoma (Disease Ontology:DOID:684); stomach disease (Disease Ontology:DOID:76); sporadic breast cancer (Disease Ontology:DOID:8029); in situ carcinoma (Disease Ontology:DOID:8719); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); brain disease (Disease Ontology:DOID:936); acute myocardial infarction (Disease Ontology:DOID:9408); steatotic liver disease (Disease Ontology:DOID:9452); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); glioma susceptibility 2 (MONDO:MONDO:0013092)",
        "pathway": " (hsa:5728);  (R-HSA-1660499);  (R-HSA-1855204);  (R-HSA-199418);  (R-HSA-202424);  (R-HSA-5628897);  (R-HSA-5674404);  (R-HSA-5689880);  (R-HSA-5689896);  (R-HSA-8943723);  (R-HSA-8948747);  (R-HSA-8948751);  (R-HSA-8986944)",
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        "class_list": "",
        "function": "A retrospective analysis suggests PTEN expression is associated with favorable clinicopathological features of breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Decoding PTEN: from biological functions to signaling pathways in tumors. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1., [UniProtKB, PubMed]; HOTAIR Promotes the Hyperactivation of PI3K/Akt and Wnt/beta-Catenin Signaling Pathways via PTEN Hypermethylation in Cervical Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Identified a 576-amino acid translational variant of PTEN, PTEN-Long, that arises from an alternative translation start site 519 base pairs upstream of the ATG initiation sequence; PTEN-Long is a membrane-permeable lipid phosphatase that is secreted from cells and can enter other cells, [RefSeq, PubMed]; NHEJ is promoted by the phosphorylation and phosphatase activity of PTEN via regulation of DNA-PKcs., [RefSeq, PubMed]; This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
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        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 40,
        "reported_mutagensis": 33,
        "reported_glycation": 0,
        "reported_snv": 237,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 55,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R904;F2YHV0;O00633;O02679;Q6ICT7",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;2.3.2.26;3.4.19.12;2.4.2.-;2.4.2.30;2.3.2.27;3.1.3.5;3.1.3.2;2.7.11.1;3.4.25.1;2.7.10.1;2.3.2.-;2.7.10.2;3.1.3.67;3.1.3.53;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74;3.1.26.n2;3.6.4.13;5.6.2.5;3.1.3.95;3.1.3.62;3.1.3.80",
        "go_molecular_function": "GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity;GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0004722 protein serine/threonine phosphatase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1903690 negative regulation of wound healing, spreading of epidermal cells;GO:0060024 rhythmic synaptic transmission;GO:0097107 postsynaptic density assembly;GO:2000808 negative regulation of synaptic vesicle clustering",
        "synthesized_glycan_count": 0,
        "hit_score": 47.4,
        "record_id": "P60484-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13761-1",
        "uniprot_id": "RUNX3_HUMAN",
        "mass": 44356.0,
        "length": 415,
        "protein_name": "Runt-related transcription factor 3",
        "gene_name": "RUNX3",
        "organism": "Human",
        "refseq_name": "runt-related transcription factor 3 isoform 1",
        "refseq_ac": "NP_001026850",
        "gene_names_uniprotkb": "RUNX3; AML2; CBFA3; PEBP2A3",
        "gene_names_refseq": "AML2; CBFA3; PEBP2aC; RUNX3",
        "protein_names_uniprotkb": "Runt-related transcription factor 3; Acute myeloid leukemia 2 protein; CBF-alpha-3; Core-binding factor subunit alpha-3; Oncogene AML-2; PEA2-alpha C; PEBP2-alpha C; Polyomavirus enhancer-binding protein 2 alpha C subunit; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit",
        "protein_names_refseq": "CBF-alpha-3; PEA2 alpha C; PEBP2 alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; acute myeloid leukemia 2 protein; acute myeloid leukemia gene 2; core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 3; oncogene AML-2; polyomavirus enhancer-binding protein 2 alpha C subunit; runt related transcription factor 3; runt-related transcription factor 3 isoform 1; transcription factor AML2",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); developmental disorder of mental health (Disease Ontology:DOID:0060037); idiopathic scoliosis (Disease Ontology:DOID:0060250); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovary epithelial cancer (Disease Ontology:DOID:2152); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); endometrial carcinoma (Disease Ontology:DOID:2871); invasive ductal carcinoma (Disease Ontology:DOID:3008); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684); in situ carcinoma (Disease Ontology:DOID:8719)",
        "pathway": " (hsa:864);  (R-HSA-4411364);  (R-HSA-8941855);  (R-HSA-8941856);  (R-HSA-8941858);  (R-HSA-8949275);  (R-HSA-8951430);  (R-HSA-8951671);  (R-HSA-8951911);  (R-HSA-8951936);  (R-HSA-8952158);  (R-HSA-9942503)",
        "pathway_count": 12,
        "publication_count": 111,
        "publication_id_list": "10201372;10228168;10318916;10531362;11809808;11809809;11940574;12091906;12637528;12855590;15138260;15688019;16135801;16140942;16164020;16373335;16510874;16652147;16738314;17377531;17377532;17923689;18220336;18579750;18593890;18772112;19351720;19571879;19800882;19808967;20100835;20353948;20599712;21637926;22201888;23333304;23481700;24171719;24229708;24366607;24715725;25418920;25469497;25576301;25645385;25892735;26004068;26154972;26364597;26375851;26414766;26811146;26992070;27217562;27846572;27920218;28063628;28228285;28832583;28855257;28904123;29242379;29351928;29493099;29508533;29557506;29632046;29632711;29769354;29789417;30315122;30410026;31015486;31092671;31154438;31217245;31530632;31844290;31937595;32157095;32161166;32357974;32387766;32488085;32502341;33123756;33141586;33298915;33592498;33717175;33912179;33936100;34211107;34531288;34932366;35051231;35318648;35580925;36284347;38665916;38704830;38735043;38913281;38923933;39534244;40596516;7607690;7622058;7835892;9727977;9751710",
        "class_list": "",
        "function": "Association between the methylations of RUNX3 in peripheral blood and lung cancer: a case-control study., [RefSeq, PubMed]; Downregulation of lncRNA MIR17HG reduced tumorigenicity and Treg-mediated immune escape of non-small-cell lung cancer cells through targeting the miR-17-5p/RUNX3 axis., [RefSeq, PubMed]; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity)., [UniProtKB, UniProtKB, PubMed]; RUNX3 exerts tumor-suppressive role through inhibiting EXOSC4 expression. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]., [RefSeq]; USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation. Erratum:[Cell Rep. 2024 Jun 25;43(6):114315. doi: 10.1016/j.celrep.2024.114315. PMID: 38795349], [RefSeq, PubMed]",
        "predicted_glycosites": 1,
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        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
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        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 13,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 13,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 13,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 18,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AJV5;Q12969;Q13760",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0005524 ATP binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0071559 response to transforming growth factor beta;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "Q13761-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NHC0-1",
        "uniprot_id": "CAN8_HUMAN",
        "mass": 79144.0,
        "length": 703,
        "protein_name": "Calpain-8",
        "gene_name": "CAPN8",
        "organism": "Human",
        "refseq_name": "calpain-8",
        "refseq_ac": "NP_001137434",
        "gene_names_uniprotkb": "CAPN8; NCL2",
        "gene_names_refseq": "CAPN8; nCL-2",
        "protein_names_uniprotkb": "Calpain-8; 3.4.22.53; New calpain 2; Stomach-specific M-type calpain; nCL-2",
        "protein_names_refseq": "calpain-8; new calpain 2; stomach-specific M-type calpain",
        "tax_id": 9606,
        "disease": "hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:388743);  (R-HSA-1474228)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "10229672;10386589;10706100;10809722;10986281;11237011;11375993;11523006;11872628;12727852;12843408;14973287;15234972;15591058;15958533;16133547;1649600;16631740;16825321;1698775;1707285;17332331;17354228;17608959;17646163;18434311;18658137;19010778;19571574;19657146;19714641;20142769;21030783;21297635;21441952;21670566;21784848;21864727;22159414;23035980;23845380;25576301;28002826;29557506;31844290;32350084;32357974;32387766;32488085;34185709;35051231;35580925;36284347;37217939;7075587;7547873;8226919;8626565;9065415;9115292;9148753;9461298;9852107",
        "class_list": "",
        "function": "3 novel loci associated with serum alpha-carotene concentrations among a population that consumed a controlled diet. While replication is necessary, the CAPN2/CAPN8 locus provides compelling evidence for an association with serum alpha-carotene concentrations and may suggest a relationship with the development and progression of cancers., [RefSeq, PubMed]; Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity)., [UniProtKB]; NCL-2/calpain 8 is active without calpain regulatory subunit and oligomerizes through C2-like domains, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RXL2",
        "ec_number_list": "3.4.22.53;3.4.22.-;3.4.22.52;3.4.22.54",
        "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "A6NHC0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NSI6-1",
        "uniprot_id": "BRWD1_HUMAN",
        "mass": 262936.0,
        "length": 2320,
        "protein_name": "Bromodomain and WD repeat-containing protein 1",
        "gene_name": "BRWD1",
        "organism": "Human",
        "refseq_name": "bromodomain and WD repeat-containing protein 1 isoform C",
        "refseq_ac": "NP_001007247",
        "gene_names_uniprotkb": "BRWD1; C21orf107; WDR9",
        "gene_names_refseq": "BRWD1; C21orf107; CILD51; DCAF19; N143; WDR9; WRD9",
        "protein_names_uniprotkb": "Bromodomain and WD repeat-containing protein 1; WD repeat-containing protein 9",
        "protein_names_refseq": "WD repeat protein WDR9-form2; WD repeat-containing protein 9; bromodomain and WD repeat-containing protein 1 isoform C; transcriptional unit N143",
        "tax_id": 9606,
        "disease": "primary ciliary dyskinesia (Disease Ontology:DOID:9562); ciliary dyskinesia, primary, 51 (MONDO:MONDO:0957396)",
        "pathway": " (hsa:54014);  (R-HSA-1266695);  (R-HSA-3247509)",
        "pathway_count": 3,
        "publication_count": 94,
        "publication_id_list": "11069618;11237011;11418668;11564764;11728342;12184921;12359327;12392711;12416996;12889071;14593182;15087120;15339660;15345777;15353558;15629448;15749844;17303166;18669648;19007248;19664995;19690332;19864382;20068231;21105711;21406692;21834987;22464331;2317865;23186163;24417533;24715725;25593309;25880248;26154972;26301565;26974155;26992070;27100087;27423467;27846572;28411811;28904123;29139090;29437277;29485866;29493099;29557506;30250168;30315122;30379171;30429286;31844290;31918398;32157095;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33389130;33537174;33592498;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34932366;35051231;35318648;35561310;35580925;36010968;36241641;36284347;37938771;7489741;7514277;7719938;8128231;8266077;8702919;8709637;9233603;9398404;9480850;9553136;9715265",
        "class_list": "",
        "function": "Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia., [RefSeq, PubMed]; Isolation and characterization of the gene located in the Down Syndrome critical region-2 of chromosome 21, [RefSeq, PubMed]; May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Required for regulation of cell morphology and cytoskeletal organization (PubMed:21834987)., [UniProtKB, UniProtKB, PubMed]; RNA-seq evidence of biallelic expression of BRWD1 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of BRWD1 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. Publication Status: Online-Only, [RefSeq, PubMed]; Study data indicate that, in both mice and humans, BRWD1 is a master orchestrator of enhancer accessibility that cooperates with transcription factor networks to drive late B-cell development. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 39,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 56,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JK25;O43721;Q5R2V0;Q5R2V1;Q6P2D1;Q8TCV3;Q96QG9;Q96QH0;Q9NUK1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031514 motile cilium;GO:0005930 axoneme",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007010 cytoskeleton organization;GO:0008360 regulation of cell shape",
        "synthesized_glycan_count": 0,
        "hit_score": 9.9,
        "record_id": "Q9NSI6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6XZF7-1",
        "uniprot_id": "DNMBP_HUMAN",
        "mass": 177347.0,
        "length": 1577,
        "protein_name": "Dynamin-binding protein",
        "gene_name": "DNMBP",
        "organism": "Human",
        "refseq_name": "dynamin-binding protein isoform b",
        "refseq_ac": "NP_001305255",
        "gene_names_uniprotkb": "DNMBP; ARHGEF36; KIAA1010; TUBA",
        "gene_names_refseq": "ARHGEF36; CTRCT48; DNMBP; TUBA",
        "protein_names_uniprotkb": "Dynamin-binding protein; Scaffold protein Tuba",
        "protein_names_refseq": "dynamin-binding protein isoform b; scaffold protein TUBA",
        "tax_id": 9606,
        "disease": "cataract 48 (Disease Ontology:DOID:0070354)",
        "pathway": " (hsa:23268);  (R-HSA-9013148)",
        "pathway_count": 2,
        "publication_count": 270,
        "publication_id_list": "10232922;10464238;10490598;10523665;10523675;10526156;10559246;10579713;10699171;10699464;10724160;10873802;11007481;11058585;11085924;11149925;11237011;11306516;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11696321;11704860;11756552;11773441;11804587;11804589;11804590;11884391;11912491;11948177;12071859;12093360;12096337;12172552;12195014;12221096;12351724;12432077;12464619;12531887;12547822;12650940;12773384;12857875;12860998;12877655;12907671;14506234;14512443;15023524;15064355;15107133;15133129;15147912;15157669;15260990;15302923;15302935;15304341;15342493;15485661;15601624;15611138;15728722;15850391;15897194;16112081;16116428;16184169;16217026;16519628;16630611;16714282;16740596;16777452;16777849;16862148;16896804;16968698;17015620;17064668;17077126;17145773;17196961;17214551;17244649;17442457;17599059;17702745;17765681;17804252;17932950;17976533;18045877;18056264;18218625;18363964;18426980;18491316;18653540;18669648;18707149;18786931;18835169;18838382;18929667;19605563;19767742;19807924;19934221;20068231;20112406;20479467;20679435;21148482;21454492;21542010;21565175;21613211;21685891;21865595;21989057;22004470;22096251;22298643;22461490;22544926;22571869;22608513;22970203;23186163;23200924;23255595;23406282;23434736;23481700;23572525;23718289;24086303;24259668;24332715;24335996;24352656;24584464;24714562;24715725;24933155;24996924;25024229;25211221;25418920;25548167;25576301;25704760;25721503;25795300;25862245;25880248;25963737;26129894;26154972;26299518;26529257;26598554;26728094;26887924;26992070;27096001;27145964;27216196;27481945;27555588;27798618;27846572;27920218;28028151;28063628;28196833;28218747;28228285;28514659;28825699;28832583;28834231;28860633;28904123;29242379;29393594;29557506;29632046;29632711;29786170;30061681;30290152;30315122;30379171;30429286;30779550;30853411;31154438;31217245;31844290;31871319;31878840;32157095;32203420;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33537174;33717175;33912179;33936100;33968037;33981976;34171305;34405274;34561969;34932366;35051231;35254053;35318648;35580925;36010968;36241641;36581221;39894887;7479768;7512369;7673236;7721814;7753201;8021274;8537347;8643598;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8810315;8816443;8994827;9013646;9113980;9268338;9305890;9405671;9438849;9490638;9497316;9659915;9670022;9829970;9843499;9846874",
        "class_list": "",
        "function": "Autophagic degradation of KAT2A/GCN5 promotes directional migration of vascular smooth muscle cells by reducing TUBA/alpha-tubulin acetylation., [RefSeq, PubMed]; DNMBP loss-of-function variants cause infantile-onset cataracts in humans., [RefSeq, PubMed]; Functions to bring together dynamin with actin regulatory proteins, [RefSeq, PubMed]; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Results confirmed DNMBP may be one of the susceptibility genes for Alzheimer's disease. GeneRIF: Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a protein belonging to the guanine nucleotide exchange factor family, and which regulates the configuration of cell junctions. It contains multiple binding sites for dynamin and thus links dynamin to actin regulatory proteins. Polymorphisms in this gene have been linked to Alzheimer's disease in some populations, though there are conflicting reports of such linkages in other populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]., [RefSeq]; Tuba controls the shaping of cell junctions through the local activation of Cdc42 and its effectors., [RefSeq, PubMed]; We observed no association of statistical significance in either the total sample or the APOE*4 non-carriers for any of the SNPs of Dynamin Binding Protein. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 38,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IVY3;Q9Y2L3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005911 cell-cell junction",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0060271 cilium assembly;GO:0008360 regulation of cell shape",
        "synthesized_glycan_count": 0,
        "hit_score": 27.3,
        "record_id": "Q6XZF7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14815-1",
        "uniprot_id": "CAN9_HUMAN",
        "mass": 79097.0,
        "length": 690,
        "protein_name": "Calpain-9",
        "gene_name": "CAPN9",
        "organism": "Human",
        "refseq_name": "calpain-9 isoform 3",
        "refseq_ac": "NP_001306605",
        "gene_names_uniprotkb": "CAPN9; NCL4",
        "gene_names_refseq": "CAPN9; GC36; nCL-4",
        "protein_names_uniprotkb": "Calpain-9; 3.4.22.-; Digestive tract-specific calpain; New calpain 4; Protein CG36; nCL-4",
        "protein_names_refseq": "calpain-9 isoform 3; digestive tract-specific calpain; new calpain 4; novel calpain large subunit-4",
        "tax_id": 9606,
        "disease": "stomach cancer (Disease Ontology:DOID:10534); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:10753);  (R-HSA-1474228)",
        "pathway_count": 2,
        "publication_count": 62,
        "publication_id_list": "10229672;10386589;10706100;10809722;10835488;10986281;11237011;11375993;11872628;12727852;12843408;14973287;15234972;15591058;15958533;16133547;1649600;16631740;16825321;1698775;1707285;17157313;17332331;17354228;17608959;18434311;18658137;19010778;19571574;19657146;19714641;20142769;20453000;21030783;21297635;21441952;21670566;21784848;21864727;22159414;23035980;23845380;25539577;27404891;29242379;29557506;29789417;31316008;34561969;35051231;36241641;36284347;7075587;7547873;8226919;8626565;9065415;9115292;9148753;9461298;9524069;9852107",
        "class_list": "",
        "function": "Calcium-regulated non-lysosomal thiol-protease., [UniProtKB, UniProtKB, UniProtKB]; Calpain-9 may play a role in breast cancer and that low expression is associated with poorer patient clinical outcome following endocrine therapy. Publication Status: Online-Only, [RefSeq, PubMed]; Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Study shows that calpain-9 is a tumor suppressor that can be regarded as a potential prognosis indicator for clinical outcomes in gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; These data provide a strong signature for tolerance of therapeutic strategies for fibrosis aimed at CAPN9 antagonism., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1APS1;B1AQI0;Q9NS74",
        "ec_number_list": "3.4.22.53;3.4.22.-;3.4.22.52;3.4.22.54",
        "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "O14815-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A2RUR9-1",
        "uniprot_id": "C144A_HUMAN",
        "mass": 165125.0,
        "length": 1427,
        "protein_name": "Coiled-coil domain-containing protein 144A",
        "gene_name": "CCDC144A",
        "organism": "Human",
        "refseq_name": "coiled-coil domain-containing protein 144A isoform a",
        "refseq_ac": "NP_055510",
        "gene_names_uniprotkb": "CCDC144A; KIAA0565",
        "gene_names_refseq": "CCDC144A",
        "protein_names_uniprotkb": "Coiled-coil domain-containing protein 144A",
        "protein_names_refseq": "coiled-coil domain-containing protein 144A isoform a; coiled-coil domain-containing protein 144A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9720)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;29557506;32938616;32991878;33141586;33592498;34509645;35051231;35580925",
        "class_list": "",
        "function": "May play a role in preventing the formation of kidney stones through inhibition of calcium oxalate monohydrate (COM) crystallization, attenuating COM-induced apoptotic injury to renal epithelial cells (PubMed:32991878). May exhibit antilithiatic (preventing the formation of kidney stones) activity through crystal binding, hindering the crystal attachment to renal epithelial cells, a pre-requisite to initiate inflammatory response (PubMed:32991878)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60311;Q6ZU57",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "A2RUR9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P10809-1",
        "uniprot_id": "CH60_HUMAN",
        "mass": 61055.0,
        "length": 573,
        "protein_name": "60 kDa heat shock protein, mitochondrial",
        "gene_name": "HSPD1",
        "organism": "Human",
        "refseq_name": "60 kDa heat shock protein, mitochondrial",
        "refseq_ac": "NP_002147",
        "gene_names_uniprotkb": "HSPD1; HSP60",
        "gene_names_refseq": "CPN60; GROEL; HLD4; HSP-60; HSP60; HSP65; HSPD1; HuCHA60; SPG13",
        "protein_names_uniprotkb": "60 kDa heat shock protein, mitochondrial; 5.6.1.7; 60 kDa chaperonin; CPN60; Chaperonin 60; HSP-60; Heat shock protein 60; Heat shock protein family D member 1; Hsp60; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein",
        "protein_names_refseq": "60 kDa chaperonin; 60 kDa heat shock protein, mitochondrial; P60 lymphocyte protein; chaperonin 60; epididymis secretory sperm binding protein; heat shock 60kDa protein 1 (chaperonin); heat shock protein 65; heat shock protein family D member 1; mitochondrial matrix protein P1; short heat shock protein 60 Hsp60s1",
        "tax_id": 9606,
        "disease": "hypomyelinating leukodystrophy 4 (Disease Ontology:DOID:0060789); hereditary spastic paraplegia 13 (Disease Ontology:DOID:0110766); glucose intolerance (Disease Ontology:DOID:10603); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); varicocele (Disease Ontology:DOID:12337); autistic disorder (Disease Ontology:DOID:12849); low tension glaucoma (Disease Ontology:DOID:13544); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); arteriosclerosis (Disease Ontology:DOID:2349); hereditary spastic paraplegia (Disease Ontology:DOID:2476); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); pulmonary fibrosis (Disease Ontology:DOID:3770); hyperglycemia (Disease Ontology:DOID:4195); myocardial infarction (Disease Ontology:DOID:5844); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074); aphthous stomatitis (Disease Ontology:DOID:9663)",
        "pathway": " (hsa:3329);  (R-HSA-1268020);  (R-HSA-8869496);  (R-HSA-9837999);  (R-HSA-9841251)",
        "pathway_count": 5,
        "publication_count": 263,
        "publication_id_list": "10.1101/2023.09.13.557529;10677244;11139588;11237011;11422376;11803047;11898127;11923310;12198491;12483302;12665801;1286669;12903899;1346131;13679392;14623864;14654843;14726512;14978097;15120623;15242332;15254020;15522782;15557401;15592455;15644312;15683237;15870080;16115876;16185709;16283109;16807696;16849325;16964243;17101804;17297443;17301219;1731090;17318229;17322306;17510655;17579211;18174896;18446792;18452278;18491316;18571143;18669648;18678864;18707149;18767875;18991276;19409522;19413330;19415658;19453276;19565483;19608861;19651622;19664994;19664995;1972619;19767391;1980192;19841671;19962426;20058876;20068231;20166139;20230923;20593814;2079031;20877010;21406692;21750375;21908771;22121020;22262461;22492505;22645359;22664726;22710082;22901435;22905912;22959702;22967762;23041349;23186163;23201127;23349634;23376792;23400302;23505495;23555621;23597483;23665396;23811401;23931759;24275569;24286120;24315374;24520911;24714562;24715725;24962340;2509558;25315652;25502872;25505266;25576301;2568584;25810538;25830298;25918392;26024233;26154972;26374642;26504172;26697887;26707565;26853435;26923599;26992070;27090790;27397612;27426517;27452731;27496948;27600516;27642048;27846572;27920218;28063628;28218747;28228285;28377575;28396416;28467828;28489076;28514659;28649982;28832583;28834231;28855257;28904123;2907406;29169891;29242379;29301859;29314611;29317506;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29671580;29786170;29789417;29932645;30120231;30179603;30192525;30315122;30397120;30410026;30429286;30444036;30484775;30524438;30573663;30746790;30779550;30833945;31020640;31092671;31154438;31217245;31222486;31327635;31373491;31530632;31611695;31695197;31844290;31848261;31998317;32119511;32157095;32161166;32265295;32302062;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33141586;33214551;33257573;33298915;33392160;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34357683;34433824;34509645;34557266;34561969;34704252;34725712;34932366;34943861;35008409;35051231;35083852;35154160;35251023;35318648;35561310;35580925;35870450;36010968;36215666;36240223;36241641;36284347;36581221;36629048;37074911;37217939;37938771;38663552;38665916;38916288;39147275;39488385;39990658;40307207;40596516;40914422;7623837;7895732;8455624;8557329;9150946;9150948",
        "class_list": "",
        "function": "Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis., [RefSeq, PubMed]; Knockdown of heat shock protein family D member 1 (HSPD1) in lung cancer cell altered secretome profile and cancer-associated fibroblast induction., [RefSeq, PubMed]; Purification of functional recombinant human mitochondrial Hsp60., [RefSeq, PubMed]; Quantitative analysis of the lysine acetylome reveals the role of SIRT3-mediated HSP60 deacetylation in suppressing intracellular Mycobacterium tuberculosis survival., [RefSeq, PubMed]; This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 23,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5M6;B7Z712;Q38L19;Q9UCR6",
        "ec_number_list": "2.3.3.1;3.4.24.64;7.1.1.2;3.6.4.10;1.4.1.3;2.1.3.3;1.2.1.3;6.4.1.3;7.1.2.2;4.2.1.2;1.2.4.1;7.1.1.8;1.8.1.4;5.6.1.7;2.3.1.168;2.3.1.-;2.3.1.37;4.98.1.1;1.1.1.38;2.3.1.9;1.2.1.36;1.7.1.-;1.2.1.28;3.4.21.53;1.1.1.37;5.3.3.8;1.3.8.1;1.3.8.5;1.1.1.42;3.1.2.2;1.1.1.41;2.3.3.10;2.8.3.5;3.5.3.1;1.2.4.2;1.1.1.30;5.3.3.21;2.7.11.2;2.7.11.-;1.16.3.1;3.4.21.92;1.1.1.35;2.7.1.23;3.4.24.-;1.1.98.-;2.5.1.39;6.2.1.-;6.2.1.4;5.6.2.3;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;4.2.1.3;6.1.1.5;2.3.1.41;3.6.1.-",
        "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0034185 apolipoprotein binding",
        "go_cellular_component": "GO:0030135 coated vesicle;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0032727 positive regulation of interferon-alpha production;GO:0043032 positive regulation of macrophage activation;GO:0045041 protein import into mitochondrial intermembrane space;GO:0048291 isotype switching to IgG isotypes",
        "synthesized_glycan_count": 0,
        "hit_score": 27.7,
        "record_id": "P10809-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BSF8-1",
        "uniprot_id": "BTBDA_HUMAN",
        "mass": 53779.0,
        "length": 475,
        "protein_name": "BTB/POZ domain-containing protein 10",
        "gene_name": "BTBD10",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing protein 10 isoform 1",
        "refseq_ac": "NP_001284671",
        "gene_names_uniprotkb": "BTBD10; GMRP1",
        "gene_names_refseq": "BTBD10; GMRP-1; GMRP1",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein 10; Glucose metabolism-related protein 1",
        "protein_names_refseq": "BTB (POZ) domain containing 10; BTB (broad-complex tramtrack and bric-a-brac/pox virus and zinc finger) domain-containing protein 10; BTB/POZ domain-containing protein 10 isoform 1; BTB/POZ domain-containing protein 10; K+ channel tetramerization protein; epididymis secretory sperm binding protein; glucose metabolism-related protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84280)",
        "pathway_count": 1,
        "publication_count": 36,
        "publication_id_list": "11237011;15556295;17924679;18160256;21267538;22388351;23320755;24714562;26992070;27600516;28228285;28832583;28834231;28904123;29242379;29493099;29557506;29786170;30315122;30379171;30833945;31844290;31848261;32157095;32938616;32983136;33592498;33968037;34087483;34185709;34561969;34932366;35561310;35580925;36010968;36284347",
        "class_list": "",
        "function": "BTBD10 appears to behave as a suppressor of cell death including neuronal cell death related to amyotrophic lateral sclerosis and an enhancer of cell growth via its positive regulation of Akt phosphorylation., [RefSeq, PubMed]; Collectively, these results suggest that the reduced expression of BTBD10 leads to motor neuron death both in vitro and in vivo., [RefSeq, PubMed]; Findings suggest that reduced BTBD10 expression is closely linked to the pathogenesis of sporadic amyotrophic lateral sclerosis, [RefSeq, PubMed]; GMRP1 regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway., [RefSeq, PubMed]; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z228;Q86WG1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center",
        "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0044342 type B pancreatic cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "Q9BSF8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51784-1",
        "uniprot_id": "UBP11_HUMAN",
        "mass": 109817.0,
        "length": 963,
        "protein_name": "Ubiquitin carboxyl-terminal hydrolase 11",
        "gene_name": "USP11",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "USP11; UHX1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 11; 3.4.19.12; Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8237);  (R-HSA-390471);  (R-HSA-5689880)",
        "pathway_count": 3,
        "publication_count": 160,
        "publication_id_list": "10444327;10982817;11237011;11566882;11923872;12084015;12502735;12917689;12917691;14661020;15053880;15314155;15916963;16214042;16901786;16964248;17290220;17443180;17697703;17873522;17897950;17980597;17981138;18172164;18408009;18452278;18467330;18632802;18636086;18669648;18775504;18991276;19011634;19015242;19135894;19188362;19363159;19398555;19424180;19608861;19651622;19664995;19838211;19874889;19910467;20068231;20096447;20228808;20233726;20368735;20501646;20601937;21098288;21239494;21362556;21406692;21571647;21596315;21659512;21849505;21962518;21972290;21995946;22029577;22085928;22128162;22216260;22424782;22544926;23159851;23301498;23395819;23486064;23747015;23824326;23825189;24056413;24260525;24275569;24366607;24397554;24493797;24714562;24715725;24724799;24756126;24896179;25197364;25305019;25342745;25467444;25505266;25576301;25578727;25880248;26154972;26811146;26992070;27846572;27862975;28510447;28904123;28992046;29293652;29437277;29493099;29557506;30410026;30484775;30568303;31020640;31154438;31530632;31844290;31848261;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34561969;34932366;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37938771;40914422;7578059;8845848;9819444",
        "class_list": "",
        "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB]; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799, PubMed:28992046). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Promotes cell proliferation by deubiquitinating phosphorylated E2F1 (PubMed:28992046)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RTX1;Q8IUG6;Q9BWE1",
        "ec_number_list": "1.2.1.12;3.5.1.-;3.5.1.98;5.2.1.8;3.2.1.45;2.4.1.-;3.2.1.-;3.2.1.46;3.6.1.-;3.4.19.12;3.6.4.13;3.4.21.53;3.1.13.-",
        "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0001222 transcription corepressor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005694 chromosome",
        "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 16.3,
        "record_id": "P51784-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H7H0-1",
        "uniprot_id": "MET17_HUMAN",
        "mass": 50734.0,
        "length": 456,
        "protein_name": "Ribosome assembly protein METTL17, mitochondrial",
        "gene_name": "METTL17",
        "organism": "Human",
        "refseq_name": "ribosome assembly protein METTL17, mitochondrial isoform 1 precursor",
        "refseq_ac": "NP_001025162",
        "gene_names_uniprotkb": "METTL17; METT11D1",
        "gene_names_refseq": "METT11D1; METTL17",
        "protein_names_uniprotkb": "Ribosome assembly protein METTL17, mitochondrial; False p73 target gene protein; Methyltransferase 11 domain-containing protein 1; Methyltransferase-like protein 17; Protein RSM22 homolog, mitochondrial",
        "protein_names_refseq": "false p73 target gene protein; methyltransferase 11 domain containing 1; methyltransferase 11 domain-containing protein 1; methyltransferase-like protein 17, mitochondrial; protein RSM22 homolog, mitochondrial; ribosome assembly protein METTL17, mitochondrial isoform 1 precursor; ribosome assembly protein METTL17, mitochondrial",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64745)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;11278769;20877624;24137763;25892735;26992070;29493099;29769354;31844290;32157095;32938616;33141586;33392160;33912179;33968037;34087483;34171305;35051231;36010968;36482135;38199006;38234605;38377789",
        "class_list": "",
        "function": "METT11D1 mutations could not explain phenotype of patients with combined oxidative phosphorylation system deficiencies., [RefSeq, PubMed]; METTL17 coordinates ferroptosis and tumorigenesis by regulating mitochondrial translation in colorectal cancer., [RefSeq, PubMed]; Mitochondrial ribosome (mitoribosome) assembly factor (PubMed:36482135, PubMed:38199006). Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body (PubMed:36482135). Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity (PubMed:38234605)., [UniProtKB, PubMed, PubMed, PubMed]; Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Possible component of the small subunit of the mitochondrial ribosome, has similarity to yeast Rsm22 (Ykl155c) mitochondrial ribosomal protein., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BSH1;Q9BZH2;Q9BZH3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0097177 mitochondrial ribosome binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0008168 methyltransferase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006412 translation;GO:0042274 ribosomal small subunit biogenesis;GO:0180026 mitochondrial small ribosomal subunit assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q9H7H0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P1Z2-1",
        "uniprot_id": "CACO1_HUMAN",
        "mass": 77336.0,
        "length": 691,
        "protein_name": "Calcium-binding and coiled-coil domain-containing protein 1",
        "gene_name": "CALCOCO1",
        "organism": "Human",
        "refseq_name": "calcium-binding and coiled-coil domain-containing protein 1 isoform 2",
        "refseq_ac": "NP_001137154",
        "gene_names_uniprotkb": "CALCOCO1; KIAA1536; PP13275; PRO4996",
        "gene_names_refseq": "CALCOCO1; Cocoa; PP13275; calphoglin",
        "protein_names_uniprotkb": "Calcium-binding and coiled-coil domain-containing protein 1; Calphoglin; Coiled-coil coactivator protein; Sarcoma antigen NY-SAR-3",
        "protein_names_refseq": "calcium-binding and coiled-coil domain-containing protein 1 isoform 2; calcium-binding and coiled-coil domain-containing protein 1; coiled-coil coactivator protein; coiled-coil leucine zipper coactivator 1; inorganic pyrophosphatase activator; sarcoma antigen NY-SAR-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57658)",
        "pathway_count": 1,
        "publication_count": 56,
        "publication_id_list": "11230166;11237011;12601173;12975309;15498874;15522220;16344550;16931570;18510355;23186163;23481700;24245781;24366607;25576301;26154972;26375851;26992070;27862975;27920218;28832583;28834231;29242379;29314611;29393594;29493099;29508533;29557506;29632046;29632711;30429286;30573663;31154438;31530632;31844290;31848261;32157095;32265295;32350084;32387766;32502341;32525583;32938616;33592498;33717175;33968037;34019948;34078123;34211107;34357683;35051231;35154160;35251023;35561310;35580925;36215666;38818751",
        "class_list": "",
        "function": "CALCOCO1 acts with VAMP-associated proteins to mediate ER-phagy., [RefSeq, PubMed]; CoCoA uses different combinations of functional domains in its synergistic coactivator function with beta-catenin or GRIP1, [RefSeq, PubMed]; Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RTN3L and CALCOCO1 function in parallel to maintain proteostasis in the endoplasmic reticulum., [RefSeq, PubMed]; Results report a novel human protein, calphoglin, which activates inorganic pyrophosphatase (IPP) and enhances phosphoglucomutase activity through the activated IPP., [RefSeq, PubMed]; Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The N terminus of CoCoA contains another activation domain , which is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CoCoA and beta-catenin., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVA8;Q6FI59;Q71RC3;Q86WF8;Q96JU3;Q9H090",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008013 beta-catenin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "Q9P1Z2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WVV9-1",
        "uniprot_id": "HNRLL_HUMAN",
        "mass": 60083.0,
        "length": 542,
        "protein_name": "Heterogeneous nuclear ribonucleoprotein L-like",
        "gene_name": "HNRNPLL",
        "organism": "Human",
        "refseq_name": "heterogeneous nuclear ribonucleoprotein L-like isoform 2",
        "refseq_ac": "NP_001136122",
        "gene_names_uniprotkb": "HNRNPLL; BLOCK24; HNRPLL; SRRF",
        "gene_names_refseq": "HNRNPLL; HNRPLL; SRRF",
        "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein L-like; Stromal RNA-regulating factor; hnRNPLL",
        "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein L-like isoform 2; stromal RNA regulating factor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92906)",
        "pathway_count": 1,
        "publication_count": 60,
        "publication_id_list": "11237011;15256261;18452278;18669648;18669861;19531498;20068231;22869377;23186163;23301498;25576301;25645385;26154972;26992070;27397612;27600516;27846572;28510447;28649982;28832583;29242379;29393594;29493099;29557506;29632711;29786170;30779550;30833945;31154438;31530632;31844290;31848261;31998317;32157095;32387766;32488085;32897882;32938616;32983136;33592498;33717175;33968037;33981976;34019948;34087483;34171305;34229054;34286904;34405274;34932366;35051231;35318648;35580925;36010968;36241641;36284347;37217939;37938771;40307207;40914422",
        "class_list": "",
        "function": "HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]., [RefSeq]; Identification of heterogeneous ribonucleoprotein L-like (hnRNPLL) as a critical inducible regulator of CD45 alternative splicing, [RefSeq, PubMed]; MYB mediates downregulation of the colorectal cancer metastasis suppressor heterogeneous nuclear ribonucleoprotein L-like during epithelial-mesenchymal transition., [RefSeq, PubMed]; Participation of SRRF (Stromal RNA Regulating Factor) isoforms in post-transcriptional events in bone marrow stromal cells; an important role in regulation of the RNA expression that directs the bone marrow stromal cells differentiation pathway, [RefSeq, PubMed]; RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53T80;Q5JB51;Q5JB52;Q659B9;Q8IVH5;Q8IVH6;Q96HR5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0045202 synapse;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0006397 mRNA processing;GO:0043484 regulation of RNA splicing",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q8WVV9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92608-1",
        "uniprot_id": "DOCK2_HUMAN",
        "mass": 211948.0,
        "length": 1830,
        "protein_name": "Dedicator of cytokinesis protein 2",
        "gene_name": "DOCK2",
        "organism": "Human",
        "refseq_name": "dedicator of cytokinesis protein 2",
        "refseq_ac": "NP_004937",
        "gene_names_uniprotkb": "DOCK2; KIAA0209",
        "gene_names_refseq": "DOCK2; IMD40",
        "protein_names_uniprotkb": "Dedicator of cytokinesis protein 2",
        "protein_names_refseq": "dedicator of cyto-kinesis 2; dedicator of cytokinesis protein 2",
        "tax_id": 9606,
        "disease": "Pierson syndrome (Disease Ontology:DOID:0060852); nephrotic syndrome type 5 (Disease Ontology:DOID:0080380); immunodeficiency 40 (Disease Ontology:DOID:0111951); primary open angle glaucoma (Disease Ontology:DOID:1070); nephrosis (Disease Ontology:DOID:2527); proteinuria (Disease Ontology:DOID:576)",
        "pathway": " (hsa:1794);  (R-HSA-164944);  (R-HSA-6798695);  (R-HSA-8980692);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013408);  (R-HSA-983231)",
        "pathway_count": 8,
        "publication_count": 448,
        "publication_id_list": "10037681;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10544125;10559246;10559471;10579713;10607567;10618429;10619026;10652265;10699171;10699464;10847683;10873388;10873802;10958683;11007481;11042108;11058585;11062261;11070003;11085924;11145705;11149925;11160719;11207612;11237011;11242053;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11680691;11689693;11704860;11707441;11744692;11751636;11756552;11773441;11803464;11804587;11804589;11804590;11864571;11884391;11895428;11912491;11919634;11950885;11961559;11967128;12032298;12071859;12093360;12096337;12134158;12176041;12177196;12195014;12221077;12221096;12351724;12376551;12393632;12427746;12432077;12531887;12546821;12547822;12650940;12665586;12857875;12877655;12923183;14512443;14514689;1464587;14654843;14675773;14718541;14737186;15020713;15023524;15033976;15064355;15107133;15133129;15144186;15147912;15169870;15247287;15302923;15339924;15342493;15485661;15507211;15542837;15579468;15592455;15601624;15611138;15710388;15728722;15814684;15850391;15858067;15866170;15897194;16002401;16054028;16081809;16112081;16116428;16184169;16188976;16217026;16243035;16243036;16282498;1630448;16339170;16467373;16473593;16492808;16507994;16519628;1660188;16630611;16636067;16702231;16762923;16776779;16777452;16777849;16862148;16896804;16914516;16968698;16979207;17027967;17060455;17077126;17145773;17158234;17196961;17214551;17244649;17269730;17562871;17583407;17599059;17698854;17702745;17765681;17804252;17932950;17942708;17976533;18006505;18045877;18056264;18158243;18191593;18218625;18249095;18347018;18396277;18426980;18653540;18662984;18829452;18838382;19269969;19293402;19367720;19369195;19494238;19562805;19581409;19605563;19608861;19635168;19664994;19673492;19690332;19713215;19901323;19934221;20030946;20058876;20101212;20166139;20400958;20460433;20530532;20591975;20627800;20628200;20660154;20679435;20810653;21148482;21151158;21351730;21378159;21454492;21542010;21565175;21613211;21621533;21654843;21699497;21730051;21865595;21872626;218813;21936715;21989057;22004470;22096251;22298643;22305756;22407364;22424782;22475431;22544926;22608513;22645359;22673745;22734669;22911862;22970203;22992742;23186163;23200924;23209303;23255595;23288169;23434736;23481700;23572525;23650620;23707487;23718289;23757206;23870057;23870313;23940355;24086303;24128008;24259668;24275569;24335996;24352656;24623723;24659802;24714562;24715725;24859002;24933155;24960694;25024229;25211221;25418920;25428919;25505266;25704760;25721503;25795300;25802875;25810538;25862245;25880248;25892735;26016997;26083206;26129894;26154972;26371245;26375851;26529257;26811146;26845023;26887924;26992070;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27806292;27846572;27920218;27986909;28063628;28112683;28114311;28196833;28218747;28228285;28446606;28514659;28584191;28649982;28832583;28834231;28904123;29089502;29146911;29242379;29358323;29382922;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30410026;30429286;30524438;30853411;31020640;31105010;31217245;31389670;31844290;31871319;32157095;32203420;32265295;32350084;32357974;32387766;32502341;32651375;32897882;32938616;32983136;33043033;33141586;33298915;33392160;33633747;33691108;33717175;33912179;33936100;33968037;34087483;3409321;34185709;34211107;34357683;34509645;34561969;34932366;35051231;35154160;35494241;35561310;35580925;36010968;36241641;36284347;36380073;36883952;36947335;37021575;37838011;7476457;7479768;7512369;7559638;7673236;7721814;7753201;7835339;7859737;8021274;8107774;8537347;8543060;8571126;8599760;8617235;8643598;8645157;8649427;8662638;8662891;8692836;8756646;8769096;8798539;8805223;8807639;8810315;8816443;8816476;8939998;8990121;8994827;9013646;9024665;9065479;9099726;9111050;9113980;9230307;9305890;9326583;9331217;9351809;9418861;9422515;9438849;9490638;9497316;9535835;9548756;9582072;9659915;9670022;9705280;9792683;9822598;9822605;9829970;9843499;9927674;9988689",
        "class_list": "",
        "function": "DOCK2 Deficiency Attenuates Abdominal Aortic Aneurysm Formation-Brief Report., [RefSeq, PubMed]; DOCK2 Promotes Asthma Development by Eliciting Airway Epithelial-Mesenchymal Transition., [RefSeq, PubMed]; DOCK2 Promotes Atherosclerosis by Mediating the Endothelial Cell Inflammatory Response., [RefSeq, PubMed]; DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription in jurkat cells, [RefSeq, PubMed]; Extra-hematopoietic immunomodulatory role of the guanine-exchange factor DOCK2. Publication Status: Online-Only, [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) that activates monomeric GTPases by catalysing the release of bound GDP in exchange for free GTP (PubMed:32651375). Activates RAC1 and RAC2, but not CDC42 (PubMed:21613211, PubMed:32651375). Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines (PubMed:21613211). May also participate in IL2 transcriptional activation via the activation of RAC2 (PubMed:21613211)., [UniProtKB, PubMed, PubMed]; Multiple Immune Defects in Two Patients with Novel DOCK2 Mutations Result in Recurrent Multiple Infection Including Live Attenuated Virus Vaccine., [RefSeq, PubMed]; The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 14,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 79,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2M3I0;Q96AK7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0042608 T cell receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0016477 cell migration;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0030036 actin cytoskeleton organization;GO:0007264 small GTPase-mediated signal transduction;GO:0050766 positive regulation of phagocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 44.9,
        "record_id": "Q92608-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P12644-1",
        "uniprot_id": "BMP4_HUMAN",
        "mass": 46555.0,
        "length": 408,
        "protein_name": "Bone morphogenetic protein 4",
        "gene_name": "BMP4",
        "organism": "Human",
        "refseq_name": "bone morphogenetic protein 4 isoform a preproprotein",
        "refseq_ac": "NP_001193",
        "gene_names_uniprotkb": "BMP4; BMP2B; DVR4",
        "gene_names_refseq": "BMP2B1; BMP2B; BMP4; MCOPS6; OFC11; ZYME",
        "protein_names_uniprotkb": "Bone morphogenetic protein 4; BMP-2B; BMP-4; Bone morphogenetic protein 2B",
        "protein_names_refseq": "bone morphogenetic protein 2B; bone morphogenetic protein 4 isoform a preproprotein",
        "tax_id": 9606,
        "disease": "tooth agenesis (Disease Ontology:DOID:0050591); atrioventricular septal defect (Disease Ontology:DOID:0050651); juvenile polyposis syndrome (Disease Ontology:DOID:0050787); stroke (Disease Ontology:DOID:0051061); ossification of the posterior longitudinal ligament of spine (Disease Ontology:DOID:0060887); physical disorder (Disease Ontology:DOID:0080015); congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); congenital anomalies of the kidney and urinary tract 2 (Disease Ontology:DOID:0080207); cleft palate-lateral synechia syndrome (Disease Ontology:DOID:0080313); orofacial cleft 11 (Disease Ontology:DOID:0080404); Axenfeld-Rieger syndrome type 3 (Disease Ontology:DOID:0110122); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); syndromic microphthalmia 6 (Disease Ontology:DOID:0111805); keratoconus (Disease Ontology:DOID:10126); prostate carcinoma (Disease Ontology:DOID:10286); esophagitis (Disease Ontology:DOID:11963); otosclerosis (Disease Ontology:DOID:12185); cartilage disease (Disease Ontology:DOID:1222); fibrodysplasia ossificans progressiva (Disease Ontology:DOID:13374); tuberous sclerosis (Disease Ontology:DOID:13515); peptic esophagitis (Disease Ontology:DOID:13976); Marfan syndrome (Disease Ontology:DOID:14323); breast cancer (Disease Ontology:DOID:1612); urinary system disease (Disease Ontology:DOID:18); calcinosis (Disease Ontology:DOID:182); epilepsy (Disease Ontology:DOID:1826); atrial heart septal defect (Disease Ontology:DOID:1882); melanoma (Disease Ontology:DOID:1909); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); prolactinoma (Disease Ontology:DOID:5394); strabismus (Disease Ontology:DOID:540); myositis ossificans (Disease Ontology:DOID:668); Barrett's esophagus (Disease Ontology:DOID:9206); cleft lip (Disease Ontology:DOID:9296)",
        "pathway": " (hsa:652);  (R-HSA-2129379);  (R-HSA-381426);  (R-HSA-8957275);  (R-HSA-9754189);  (R-HSA-9758920);  (R-HSA-9761174);  (R-HSA-9793380);  (R-HSA-9827857);  (R-HSA-9830364);  (R-HSA-9830674);  (R-HSA-9834899)",
        "pathway_count": 12,
        "publication_count": 135,
        "publication_id_list": "10.1101/2023.09.13.557529;10025398;10026136;10077652;10218588;10424889;10512690;10544250;10614670;10646116;10681634;10810289;10898936;10912521;10930463;10951195;10990447;11158056;11237011;11250653;11264294;11316783;11522292;11606061;11739083;11751371;11788658;11970960;12241545;12358597;12379487;12404109;12415008;12429738;12466191;12810533;12904166;1370451;1383255;1400330;14701737;15020244;15110706;15126567;15308688;15381701;15469690;15485880;15525596;15642270;17047378;17068183;1708799;17249697;17312271;17324935;17985932;18042803;18184661;18252212;18305125;18339631;18550259;18729794;19249007;21245162;21646718;24357672;2476804;2479552;25543152;25693565;25868050;25921273;25936800;26091039;26189426;28178531;28985527;29091993;29212066;29234012;29557506;29713018;30590035;30833945;31363885;31844290;31848261;3201241;32127035;32350084;32448362;33308444;33470497;33537174;33608411;33968037;34065661;34171305;35051231;35318648;35411086;36284347;38755724;39196111;39217886;7500359;7519608;7523391;7525263;7525634;7525824;7527330;7534784;7538844;7543116;7579580;7588299;7683646;7689487;8006002;8781553;8817670;8894645;8895516;8964575;9417125;9497324;9701626;9709957;9725916;9733769;9786878;9922210",
        "class_list": "",
        "function": "Bone morphogenetic protein 4 inhibits corneal neovascularization by blocking NETs-induced disruption to corneal epithelial barrier., [RefSeq, PubMed]; Bone morphogenic protein-4 availability in the cardiac microenvironment controls inflammation and fibrosis in autoimmune myocarditis., [RefSeq, PubMed]; Expression pattern of the bone morphogenetic protein-4 and its relationship with inflammation, vascular injury in patients suffered the arterial occlusive diseases., [RefSeq, PubMed]; Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (PubMed:31363885). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:25868050, PubMed:8006002). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:25868050, PubMed:29212066). Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus (By similarity). Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades (PubMed:31363885). For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (PubMed:31363885)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways., [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 36,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UM80",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:1901331 positive regulation of odontoblast differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001934 positive regulation of protein phosphorylation;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 13.8,
        "record_id": "P12644-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95861-1",
        "uniprot_id": "BPNT1_HUMAN",
        "mass": 33392.0,
        "length": 308,
        "protein_name": "3'(2'),5'-bisphosphate nucleotidase 1",
        "gene_name": "BPNT1",
        "organism": "Human",
        "refseq_name": "3'(2'),5'-bisphosphate nucleotidase 1 isoform 2",
        "refseq_ac": "NP_001273078",
        "gene_names_uniprotkb": "BPNT1",
        "gene_names_refseq": "BPNT1; HEL20; HsPIP; PIP",
        "protein_names_uniprotkb": "3'(2'),5'-bisphosphate nucleotidase 1; 3'-phosphoadenosine 5'-phosphate phosphatase; 3.1.3.57; 3.1.3.7; BPntase 1; Bisphosphate 3'-nucleotidase 1; HsPIP; Inositol-polyphosphate 1-phosphatase; PAP phosphatase",
        "protein_names_refseq": "3'(2'),5'-bisphosphate nucleotidase 1 isoform 2; 3'-phosphoadenosine 5'-phosphate phosphatase; BPntase 1; BPntase; PAP phosphatase; PAP-inositol-1,4-phosphatase; bisphosphate 3'-nucleotidase 1; epididymis luminal protein 20; inositol-polyphosphate 1-phosphatase; testicular tissue protein Li 29",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10380);  (R-HSA-156584)",
        "pathway_count": 2,
        "publication_count": 93,
        "publication_id_list": "10199779;10224133;10503886;10512730;10675562;11077054;11154739;11237011;11457664;11739018;12039030;12145317;12372849;12889478;14622112;14672934;15358107;18606703;18672380;20068231;20628624;22223895;2268288;23186163;23301498;23479625;23481380;23481700;24275569;25576301;25645385;25880248;25892735;26375851;26992070;27600516;27846572;27862975;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29508533;29557506;29769354;29789417;30429286;31844290;32157095;32350084;32357974;32502341;32938616;32983136;33298915;33592498;33691108;33912179;33936100;33968037;33981976;34019948;34171305;34229054;34357683;34509645;34932366;35051231;35132862;35251023;35580925;36010968;36241641;37938771;38493427;38665916;40596516;40914422;6139755;6770210;7678732;7779757;8185618;8697101;9034160;9463486;9501187;9566739;9852044",
        "class_list": "",
        "function": "BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]., [RefSeq]; CircRNA HLCS regulates lens epithelial cell apoptosis via miR-338-3p/BPNT1 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Meta-analysis of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and inositol 1,4-bisphosphate (Ins(1,4)P2) to inositol 4-phosphate (PubMed:10675562). Is also able to hydrolyze adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) (By similarity). Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism. Is not active on 3'-AMP, inositol-1-phosphate and inositol-1,4,5-triphosphate (PubMed:10675562)., [UniProtKB, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7C8;B4DPS5;B4DUS9;D3DTA9;Q8WVL5;Q9UGJ3",
        "ec_number_list": "3.1.3.57;3.1.3.7",
        "go_molecular_function": "GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity;GO:0046872 metal ion binding;GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007399 nervous system development;GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0006139 nucleobase-containing compound metabolic process;GO:0046854 phosphatidylinositol phosphate biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.6,
        "record_id": "O95861-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P25440-1",
        "uniprot_id": "BRD2_HUMAN",
        "mass": 88061.0,
        "length": 801,
        "protein_name": "Bromodomain-containing protein 2",
        "gene_name": "BRD2",
        "organism": "Human",
        "refseq_name": "bromodomain-containing protein 2 isoform 1",
        "refseq_ac": "NP_001106653",
        "gene_names_uniprotkb": "BRD2; KIAA9001; RING3",
        "gene_names_refseq": "BRD2-IT1; BRD2; D6S113E; FSHRG1; FSH; FSRG1; NAT; O27.1.1; RING3; RNF3",
        "protein_names_uniprotkb": "Bromodomain-containing protein 2; O27.1.1",
        "protein_names_refseq": "BRD2 intronic transcript 1; bromodomain-containing protein 2 isoform 1; female sterile homeotic-related gene 1; really interesting new gene 3 protein",
        "tax_id": 9606,
        "disease": "B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); melanoma (Disease Ontology:DOID:1909); photosensitivity disease (Disease Ontology:DOID:3159); juvenile myoclonic epilepsy (Disease Ontology:DOID:4890); B-cell lymphoma (Disease Ontology:DOID:707)",
        "pathway": " (hsa:6046);  (R-HSA-8951936)",
        "pathway_count": 2,
        "publication_count": 97,
        "publication_id_list": "11237011;12091906;1352711;15138260;15302935;16227282;17081983;17148447;17287340;17344846;17848202;18406326;18452278;18669648;19413330;19651622;19690332;20048151;20068231;20709061;20871596;21406692;23186163;23481700;24229708;24275569;24715725;25576301;25593309;26154972;26992070;27846572;28228285;28262505;28832583;28834231;28904123;29242379;29351928;29493099;29557506;29786170;30315122;30429286;30484775;30524438;30620550;31092671;31217245;31844290;31969702;32119511;32157095;32193360;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33234676;33298915;33392160;33592498;33691108;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34229054;34346116;34493364;34509645;34710325;34932366;35051231;35138101;35410381;35580925;36010968;36215666;36241641;36284347;37059338;37731000;37938771;39534244;40596516;8595877;8781126",
        "class_list": "",
        "function": "BRD2 regulation of sigma-2 receptor upon cholesterol deprivation. Publication Status: Online-Only, [RefSeq, PubMed]; Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2., [RefSeq, PubMed]; PD-L1 is upregulated via BRD2 in head and neck squamous cell carcinoma models of acquired cetuximab resistance., [RefSeq, PubMed]; The BRD2 gene is homologous to the mammalian cell cycle regulator TAFII250 and the Drosophila trithorax group gene female sterile homeotic; the gene encodes a nuclear-localized kinase with signal transduction activity., [RefSeq, PubMed]; The Epigenetic Reader, Bromodomain Containing 2, Mediates Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1., [RefSeq, PubMed]; This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 19,
        "reported_mutagensis": 20,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 5,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2AAU0;B0S7P0;B1AZT1;O00699;O00700;Q15310;Q5STC9;Q63HQ9;Q658Y7;Q6P3U2;Q969U4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0004674 protein serine/threonine kinase activity;GO:0042393 histone binding;GO:0140033 acetylation-dependent protein binding;GO:0140011 histone H4K12ac reader activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0006334 nucleosome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "P25440-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99708-1",
        "uniprot_id": "CTIP_HUMAN",
        "mass": 101942.0,
        "length": 897,
        "protein_name": "DNA endonuclease RBBP8",
        "gene_name": "RBBP8",
        "organism": "Human",
        "refseq_name": "DNA endonuclease RBBP8 isoform a",
        "refseq_ac": "NP_002885",
        "gene_names_uniprotkb": "RBBP8; CTIP",
        "gene_names_refseq": "COM1; CTIP; JAWAD; JWDS; RBBP8; RIM; SAE2; SCKL2",
        "protein_names_uniprotkb": "DNA endonuclease RBBP8; 3.1.-.-; CtBP-interacting protein; CtIP; RBBP-8; RIM; Retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; SAE2; Sporulation in the absence of SPO11 protein 2 homolog",
        "protein_names_refseq": "CTBP-interacting protein; DNA endonuclease RBBP8 isoform a; DNA endonuclease RBBP8; retinoblastoma binding protein 8; sporulation in the absence of SPO11 protein 2 homolog",
        "tax_id": 9606,
        "disease": "Seckel syndrome 2 (Disease Ontology:DOID:0070013); Jawad syndrome (MONDO:MONDO:0009622)",
        "pathway": " (hsa:5932);  (R-HSA-5685938);  (R-HSA-5685939);  (R-HSA-5685942);  (R-HSA-5693537);  (R-HSA-5693554);  (R-HSA-5693568);  (R-HSA-5693579);  (R-HSA-5693607);  (R-HSA-5693616);  (R-HSA-6804756);  (R-HSA-69473);  (R-HSA-8953750);  (R-HSA-912446);  (R-HSA-9701192);  (R-HSA-9704331);  (R-HSA-9704646);  (R-HSA-9709570);  (R-HSA-9709603)",
        "pathway_count": 19,
        "publication_count": 367,
        "publication_id_list": "10029069;10212258;10373512;10435622;10438626;10500146;10551859;10562567;10570149;10570174;10604467;10673500;10673501;10710310;10728666;10733923;10734115;10744977;10764811;10801132;10856253;10859164;10884347;10910365;10921897;10928988;11006276;11080452;11139606;11171983;11237011;11239457;11292842;11301010;11340072;11376695;11390642;11440997;11447225;11459987;11511362;11546806;11551930;11571269;11689934;11698410;11740489;11751635;11751867;11780126;11832208;12004135;12064478;12139939;12152085;12191481;12226092;12228710;12370410;12379650;12393879;12545175;12578958;12686547;12702766;12721304;12750383;12791985;12851404;12909625;12912992;12914926;14527420;14576433;14654780;14702041;14716019;14734547;15014447;15053879;15084581;15135726;15164066;15189136;15190204;15304223;15359272;15485900;15485915;15536069;15561706;15665856;15703751;15707391;15866171;15916957;16012167;16101277;16123081;16148040;16153896;16292313;16322221;16322561;16327781;16337601;16360315;16530042;16581787;16793542;16818604;16885023;17001316;17108107;17114795;17200668;17200671;17200672;17289582;17322306;17349958;17420451;17515903;17525332;17541404;17575048;17591690;17600109;17928296;17962301;17965729;17977839;17981954;17996710;17996711;18171670;18171986;18256600;18317453;18452278;18490454;18535008;18539610;18541667;18562691;18757400;18805091;18923075;18957201;18971343;19074197;19121998;19202191;19268590;19270026;19357644;19369211;19419957;19584259;19596236;19609323;19664995;19759395;19941829;19965871;20044539;20044541;20062530;20064462;20068231;20154705;20207730;20233725;20483915;20647759;20729832;20729858;20729859;20818382;20829486;20871615;20871616;20959462;20965415;21052091;21240188;21263215;21317932;21325134;21335604;21520333;21565612;21596310;21659603;21680713;21777809;21799032;21804533;21816818;21893598;21998596;22021381;22024395;22194698;22231403;22593209;22635276;22645308;22661229;22661230;22792074;22977173;23000554;23144634;23149936;23186163;23273981;23345434;23353824;23468639;23485397;23509288;23623683;23676219;23686288;23731732;23754376;23810717;23954429;24013206;24076221;24141787;24145406;24196441;24371268;24389050;24485656;24509834;24627085;24714562;24715725;24831703;24874608;25113031;25122754;25201414;25218447;25267294;25349192;25558984;25576301;25642960;25642963;25643323;25659039;25755297;25789972;25880248;26145171;26502057;26721387;26807646;26992070;27561354;27814491;27846572;27889449;27899578;27920218;28063628;28089683;28132842;28158555;28228285;28240985;28319063;28740167;28832583;28834754;28904123;29042561;29133916;29165669;29242379;29244158;29557506;29608566;29632046;29632711;29786170;30202980;30289697;30297868;30311374;30315122;30410026;30524438;30601117;30787182;30833945;31217245;31492838;31530632;31586400;31636395;31757951;31802118;31844290;31934630;32157095;32347940;32357974;32387766;32502341;32732220;32897882;32938616;32983136;33097710;33195396;33271982;33298915;33392160;33406258;33592498;33717175;33836577;33907233;33968037;33978741;33981976;34071949;34129781;34171305;34440403;34509645;34616022;34932366;35219381;35318648;35580925;36010636;36010968;36155803;36172813;36241641;37615686;38324469;40307207;7623816;8003475;8702565;8929543;9008167;9214649;9311981;9450758;9501179;9535825;9689056;9704927;9705271;9721205;9781043;9826763;9837724;9925639",
        "class_list": "",
        "function": "A novel RBBP8(p.E281*) germline mutation is a predisposing mutation in familial hereditary cancer syndrome., [RefSeq, PubMed]; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:31802118). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; NUDT16 regulates CtIP PARylation to dictate homologous recombination repair., [RefSeq, PubMed]; SIAH2 regulates DNA end resection and replication fork recovery by promoting CtIP ubiquitination., [RefSeq, PubMed]; The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The mechanism of radiotherapy for lung adenocarcinoma in promoting protein SIRT6-mediated deacetylation of RBBP8 to enhance the sensitivity of targeted therapy., [RefSeq, PubMed]; The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 35,
        "reported_mutagensis": 36,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NKN2;A8K8W6;E7ETY1;O75371;Q8NHQ3",
        "ec_number_list": "2.7.11.1;2.4.2.-;2.4.2.30;6.5.1.1;2.7.11.22;2.7.7.7;3.1.11.-;2.3.2.27;3.1.-.-;5.6.2.4;3.6.4.-;5.6.2.1;2.3.1.-;2.3.1.286;3.6.-.-;2.3.1.48;3.1.22.-;3.1.11.2;5.6.2.3;5.6.2.-;5.6.2.2",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003684 damaged DNA binding;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0035861 site of double-strand break;GO:0005694 chromosome",
        "go_biological_process": "GO:0051301 cell division;GO:0000724 double-strand break repair via homologous recombination;GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing;GO:0051321 meiotic cell cycle;GO:0044818 mitotic G2/M transition checkpoint",
        "synthesized_glycan_count": 0,
        "hit_score": 37.1,
        "record_id": "Q99708-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HCU9-1",
        "uniprot_id": "BRMS1_HUMAN",
        "mass": 28461.0,
        "length": 246,
        "protein_name": "Breast cancer metastasis-suppressor 1",
        "gene_name": "BRMS1",
        "organism": "Human",
        "refseq_name": "breast cancer metastasis-suppressor 1 isoform 1",
        "refseq_ac": "NP_056214",
        "gene_names_uniprotkb": "BRMS1",
        "gene_names_refseq": "BRMS1",
        "protein_names_uniprotkb": "Breast cancer metastasis-suppressor 1",
        "protein_names_refseq": "breast cancer metastasis suppressor 1; breast cancer metastasis-suppressor 1 isoform 1",
        "tax_id": 9606,
        "disease": "invasive ductal carcinoma (Disease Ontology:DOID:3008)",
        "pathway": " (hsa:25855);  (R-HSA-3214815);  (R-HSA-9679191)",
        "pathway_count": 3,
        "publication_count": 74,
        "publication_id_list": "10087012;10444591;10449787;10748112;10850410;10904264;10922406;10926844;11237011;11509652;11739383;11742974;11822878;11909966;12032298;12414911;12724404;14581478;16115318;16522641;17000776;17211407;17662961;20068231;20223979;20830743;20935672;21587264;21777593;22085717;22401777;22552008;22645359;22814904;23481700;23641311;24272870;24366607;24584101;24714562;25576301;25801024;25880248;26002965;26101246;26728094;26771717;27846572;27920218;28228285;28425720;28904123;29632711;29945920;30201761;30315122;31048504;31844290;32157095;32357974;32502341;32853985;32938616;33717175;33968037;34171305;34788285;35051231;36197962;36284039;7513682;9150135;9651585;9790534",
        "class_list": "",
        "function": "A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos., [RefSeq, PubMed]; BRMS1 functions as a metastasis suppressor in more than one tumor type(i.e., breast carcinoma and cutaneous melanoma)by modifying several metastasis-associated phenotypes., [RefSeq, PubMed]; Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma., [RefSeq, PubMed]; N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1., [RefSeq, PubMed]; Perturbation of BRMS1 interactome reveals pathways that impact metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "prognostic",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IAI2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0051059 NF-kappaB binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070822 Sin3-type complex",
        "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q9HCU9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BZG1-1",
        "uniprot_id": "RAB34_HUMAN",
        "mass": 29044.0,
        "length": 259,
        "protein_name": "Ras-related protein Rab-34",
        "gene_name": "RAB34",
        "organism": "Human",
        "refseq_name": "ras-related protein Rab-34 isoform 4",
        "refseq_ac": "NP_001138414",
        "gene_names_uniprotkb": "RAB34; NARR; RAB39; RAH",
        "gene_names_refseq": "NARR; OFD20; RAB34; RAB39; RAH",
        "protein_names_uniprotkb": "Ras-related protein Rab-34; 3.6.5.2; Ras-related protein Rab-39; Ras-related protein Rah",
        "protein_names_refseq": "nine amino-acid residue-repeats; ras-related protein Rab-34 isoform 4; ras-related protein Rab-39; ras-related protein Rah",
        "tax_id": 9606,
        "disease": "orofaciodigital syndrome XX (Disease Ontology:DOID:0060962)",
        "pathway": " (hsa:83871);  (R-HSA-8873719)",
        "pathway_count": 2,
        "publication_count": 70,
        "publication_id_list": "11141079;11237011;11389151;11447212;11675392;14668488;16401880;1648736;17114793;17411337;17881736;18532927;18669648;18707149;18767875;19603039;19651622;20068231;21255211;21406692;21586586;22223895;22694141;23186163;24023390;25341920;26969162;27113757;27600516;27846572;27920218;28218747;28832583;28904123;29242379;29557506;30429286;30484775;30833945;31530632;31848261;32157095;32161166;32350084;32502341;32938616;33537174;33592498;33968037;34171305;34357683;35051231;35285960;35580925;35871249;36010968;36215666;37384395;37619988;38183057;38665916;7957092;7991565;8164745;8349690;8375503;8513495;8631982;8662963;8836150",
        "class_list": "",
        "function": "Define Rab34 as a novel member of the secretory pathway acting at the Golgi, [RefSeq, PubMed]; Localization, traffic and function of Rab34 in adipocyte lipid and endocrine functions. Publication Status: Online-Only, [RefSeq, PubMed]; NARR is ubiquitously expressed and resides in nucleoli where it colocalizes with ribosomal DNA gene clusters., [RefSeq, PubMed]; Pathogenic RAB34 variants impair primary cilium assembly and cause a novel oral-facial-digital syndrome., [RefSeq, PubMed]; Rab34 plays a critical role as a bidirectional regulator of osteoclastogenesis., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. An alternatively spliced transcript variant produces the nine-amino acid residue-repeats (NARR) protein, which is a functionally distinct nucleolar protein resulting from a different reading frame. [provided by RefSeq, Dec 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E3A0;E9PEJ9;Q5BJE6;Q8NCJ8;Q96AR4",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.1.-;2.5.1.60;3.6.5.4;2.7.11.1;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031267 small GTPase binding;GO:0030742 GTP-dependent protein binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005929 cilium;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0090382 phagosome maturation;GO:0072659 protein localization to plasma membrane;GO:0060271 cilium assembly;GO:0043001 Golgi to plasma membrane protein transport",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "Q9BZG1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q12830-1",
        "uniprot_id": "BPTF_HUMAN",
        "mass": 338262.0,
        "length": 3046,
        "protein_name": "Nucleosome-remodeling factor subunit BPTF",
        "gene_name": "BPTF",
        "organism": "Human",
        "refseq_name": "nucleosome-remodeling factor subunit BPTF isoform 2",
        "refseq_ac": "NP_004450",
        "gene_names_uniprotkb": "BPTF; FAC1; FALZ",
        "gene_names_refseq": "BPTF; FAC1; FALZ; NEDDFL; NURF301",
        "protein_names_uniprotkb": "Nucleosome-remodeling factor subunit BPTF; Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen",
        "protein_names_refseq": "bromodomain and PHD domain transcription factor; bromodomain and PHD finger-containing transcription factor; fetal Alz-50 clone 1 protein; fetal Alz-50 reactive clone 1; fetal Alzheimer antigen; nucleosome remodeling factor, large subunit; nucleosome-remodeling factor subunit BPTF isoform 2; nucleosome-remodeling factor subunit BPTF",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (Disease Ontology:DOID:0070514); Alzheimer's disease (Disease Ontology:DOID:10652); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); Kaposi's sarcoma (Disease Ontology:DOID:8632)",
        "pathway": " (hsa:2186)",
        "pathway_count": 1,
        "publication_count": 150,
        "publication_id_list": "10403843;10575013;10662542;10727212;11237011;14609955;15310751;15379550;16728976;16728978;17081983;17525332;18042461;18669648;19608861;19690332;20068230;20068231;20305658;21158410;21406692;22464331;22661428;23186163;23481700;24129315;24397554;24714562;24715725;25218447;25505266;25576301;25593309;25645385;25755297;25772364;26154972;26375851;26758079;26992070;27114449;27543614;27600516;27846572;27869121;27920218;28218747;28228285;28446606;28514659;28657654;28801535;28832583;28834231;28904123;28942966;29237092;29242379;29249144;29351928;29437277;29493099;29508533;29557506;29632711;30059200;30192525;30315122;30379171;30410026;30484775;30620550;30779550;30833945;31092671;31154438;31217245;31222486;31492838;31530632;31637018;31844290;31848261;31998317;32119511;32157095;32161166;32357974;32387766;32488085;32502341;32574038;32897882;32938616;32938750;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33633747;33691108;33912179;33968037;33981976;34019948;34065225;34087483;34171305;34357683;34405274;34509645;34725712;34846842;34931806;35051231;35132862;35154160;35254053;35289036;35318648;35513511;35561310;35580925;35705054;36010968;36153657;36240223;36284347;36529788;36967443;37217939;37340703;37541260;37938771;38380509;38665916;38838015;38940430;39302247;39531497;39534244;40136647;40307207;40596516;41350704;7621746;9225734",
        "class_list": "",
        "function": "A role of BPTF in viral oncogenicity delineated through studies of heritable Kaposi sarcoma., [RefSeq, PubMed]; NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation., [RefSeq, PubMed]; PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Targeting regulation of VEGF by BPTF in non-small cell lung cancer and its potential clinical significance. Publication Status: Online-Only, [RefSeq, PubMed]; The effect of growth hormone treatment in children with novel BPTF gene variants: A report of two cases and literature review. Review article, [RefSeq, PubMed]; This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 85,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 85,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 85,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 106,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 5,
        "glyco_site_count": 88,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NX67;Q7Z7D6;Q9UIG2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 23.8,
        "record_id": "Q12830-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BY67-1",
        "uniprot_id": "CADM1_HUMAN",
        "mass": 48509.0,
        "length": 442,
        "protein_name": "Cell adhesion molecule 1",
        "gene_name": "CADM1",
        "organism": "Human",
        "refseq_name": "cell adhesion molecule 1 isoform E precursor",
        "refseq_ac": "NP_001091987",
        "gene_names_uniprotkb": "CADM1; IGSF4A; IGSF4; NECL2; SYNCAM; TSLC1",
        "gene_names_refseq": "BL2; CADM1; IGSF4A; IGSF4; NECL2; Necl-2; RA175; ST17; SYNCAM; TSLC1; sTSLC-1; sgIGSF; synCAM1",
        "protein_names_uniprotkb": "Cell adhesion molecule 1; IgSF4; Immunoglobulin superfamily member 4; NECL-2; Nectin-like protein 2; SgIgSF; Spermatogenic immunoglobulin superfamily; SynCAM; Synaptic cell adhesion molecule; TSLC-1; Tumor suppressor in lung cancer 1",
        "protein_names_refseq": "TSLC-1; TSLC1/Nectin-like 2/IGSF4; cell adhesion molecule 1 isoform E precursor; immunoglobulin superfamily member 4; nectin-like 2; nectin-like protein 2; spermatogenic immunoglobulin superfamily; synaptic cell adhesion molecule; tumor suppressor in lung cancer 1",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); breast carcinoma (Disease Ontology:DOID:3459); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)",
        "pathway": " (hsa:23705);  (R-HSA-418990);  (R-HSA-420597)",
        "pathway_count": 3,
        "publication_count": 73,
        "publication_id_list": "10.1101/2023.09.13.557529;10225955;11237011;11279526;11544254;12050160;12079507;12112527;12234973;12759359;12920246;12925956;13679854;14633730;15184878;15741237;15781451;15811952;15893517;15905536;16335952;16467305;17967169;19159218;19349973;19354288;21131357;22438059;23090970;23871486;24190977;24503895;24722188;25268382;25372031;28218747;28832583;29242379;29391424;29393594;29557506;29632711;29698475;29741879;29786170;30237853;30626607;31154438;31844290;32157095;32350084;32938616;33592498;33633747;33936100;34078123;34087483;34171305;35051231;35154160;35580925;36010968;36241641;36523593;36943432;37074911;37166307;37291193;37814227;38665916;7806582;9219219;9845526",
        "class_list": "glycogene",
        "function": "(Microbial infection) Induces cell fusion in neuron infected by a neuropathogenic strain of measles. Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus., [UniProtKB, PubMed]; Alteration of TSLC1 is involved in prostate cancer, [RefSeq, PubMed]; Analysis of the key ligand receptor CADM1_CADM1 in the regulation of thyroid cancer based on scRNA-seq and bulk RNA-seq data. Publication Status: Online-Only, [RefSeq, PubMed]; CADM1 impairs the effect of miR-1246 on promoting cell cycle progression in chemo-resistant leukemia cells. Publication Status: Online-Only, [RefSeq, PubMed]; Cell adhesion molecule 1 expression in mycosis fungoides versus parapsoriasis versus inflammatory dermatosis: an immunohistochemical comparative study., [RefSeq, PubMed]; Interaction of the Hemagglutinin Stalk Region with Cell Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion Protein., [RefSeq, PubMed]; Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:12050160, PubMed:22438059). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). In mast cells, may mediate attachment to and promote communication with nerves (PubMed:15905536). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:22438059). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed:11279526, PubMed:12234973). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed:12920246)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production., [RefSeq, PubMed]; TSLC1 mediates intracellular adhesion through homophilic interactions in a Ca(2+)/Mg(2+)-independent manner, [RefSeq, PubMed]; The TSLC1 promoter region has many methylated cytosines in the CpG islands in chromosome 11q LOH in breast cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 12,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 12,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 12,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 494,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 48,
        "disease_count": 5,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4FVB5;F5H0J4;H0YGA7;H1ZZV9;H1ZZW1;H1ZZW2;Q86WB8;Q8N2F4;X5D2C8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0030165 PDZ domain binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016323 basolateral plasma membrane;GO:0045202 synapse;GO:0043005 neuron projection",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006915 apoptotic process;GO:0001819 positive regulation of cytokine production;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 13.5,
        "record_id": "Q9BY67-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P78347-1",
        "uniprot_id": "GTF2I_HUMAN",
        "mass": 112416.0,
        "length": 998,
        "protein_name": "General transcription factor II-I",
        "gene_name": "GTF2I",
        "organism": "Human",
        "refseq_name": "general transcription factor II-I isoform 5",
        "refseq_ac": "NP_001157108",
        "gene_names_uniprotkb": "GTF2I; BAP135; WBSCR6",
        "gene_names_refseq": "BAP135; BTKAP1; DIWS; GTF2I; GTFII-I; IB291; SPIN; TFII-I; WBSCR6; WBS",
        "protein_names_uniprotkb": "General transcription factor II-I; BAP-135; BTK-associated protein 135; Bruton tyrosine kinase-associated protein 135; GTFII-I; SPIN; SRF-Phox1-interacting protein; TFII-I; Williams-Beuren syndrome chromosomal region 6 protein",
        "protein_names_refseq": "BTK-associated protein, 135kD; Bruton tyrosine kinase-associated protein 135; SRF-Phox1-interacting protein; Williams-Beuren syndrome chromosome region 6; general transcription factor II-I isoform 5; general transcription factor II-I",
        "tax_id": 9606,
        "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)",
        "pathway": " (hsa:2969)",
        "pathway_count": 1,
        "publication_count": 156,
        "publication_id_list": "10373551;10380706;10648599;11237011;11313464;11373296;11934902;12082086;15104674;15302935;15561718;15664986;16738337;16964243;17074750;17081983;17924679;18160138;18452278;18669648;18691976;18767875;18991276;19111598;19413330;19651622;19664994;19664995;19690332;20068231;20112406;20934997;21406692;22223895;22645359;23186163;23301498;23481700;24129315;24275569;24366607;24714562;24715725;25114211;25218447;25367160;25418920;25469497;25576301;25645385;25755297;25772364;25810538;25892735;26154972;26728094;26811146;26992070;27543614;27600516;27846572;27862975;27869121;27920218;28063628;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30379171;30410026;30429286;30484775;30524438;30779550;30784271;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31900622;31937595;31998317;32119511;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33465208;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34357683;34405274;34509645;34561969;34725712;34932366;35008409;35051231;35083852;35132862;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37938771;38097729;38416640;38665916;39531497;40307207;40596516;40914422;9012831;9334314;9384587;9466987;9837922",
        "class_list": "",
        "function": "Analyzed promoter regions of TFII-I genes and described their additional exons, as well as tested tissue specificity of both previously reported and novel alternatively spliced isoforms, [RefSeq, PubMed]; Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Loss of GTF2I promotes neuronal apoptosis and synaptic reduction in human cellular models of neurodevelopment., [RefSeq, PubMed]; Neuronal Gtf2i deletion alters mitochondrial and autophagic properties. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 47,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O14743;O15359;O43546;O43588;O43589;Q75M85;Q75M86;Q75M87;Q75M88;Q86U51;Q9BSZ4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016525 negative regulation of angiogenesis;GO:0006366 transcription by RNA polymerase II;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 16.3,
        "record_id": "P78347-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BV47-1",
        "uniprot_id": "DUS26_HUMAN",
        "mass": 23946.0,
        "length": 211,
        "protein_name": "Dual specificity protein phosphatase 26",
        "gene_name": "DUSP26",
        "organism": "Human",
        "refseq_name": "dual specificity protein phosphatase 26",
        "refseq_ac": "NP_001292044",
        "gene_names_uniprotkb": "DUSP26; DUSP24; LDP4; MKP8; NATA1; SKRP3",
        "gene_names_refseq": "DSP-4; DUSP24; DUSP26; LDP-4; LDP4; MKP-8; MKP8; NATA1; NEAP; SKRP3",
        "protein_names_uniprotkb": "Dual specificity protein phosphatase 26; 3.1.3.16; 3.1.3.48; DSP-4; Dual specificity phosphatase SKRP3; LDP-4; Low-molecular-mass dual-specificity phosphatase 4; MAP kinase phosphatase 8; MKP-8; Mitogen-activated protein kinase phosphatase 8; Novel amplified gene in thyroid anaplastic cancer",
        "protein_names_refseq": "MAP kinase phosphatase 8; Novel amplified gene in thyroid anaplastic cancer; dual specificity phosphatase 26 (putative); dual specificity phosphatase SKRP3; dual specificity protein phosphatase 26; low-molecular-mass dual-specificity phosphatase 4; mitogen-activated protein kinase phosphatase 8; neuroendocrine-associated phosphatase",
        "tax_id": 9606,
        "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)",
        "pathway": " (hsa:78986)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;15796912;16581800;16924234;17001450;23481700;33466673;34179958;35278641;35313355;36053282",
        "class_list": "",
        "function": "A Review of DUSP26: Structure, Regulation and Relevance in Human Disease. Review article Publication Status: Online-Only, [RefSeq, PubMed]; DUSP26 effectively dephosphorylates p38 and has a little effect on extracellular signal-regulated kinase in anaplastic thyroid cancer., [RefSeq, PubMed]; DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells., [RefSeq, PubMed]; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate., [UniProtKB, UniProtKB]; Dusp26 phosphatase regulates mitochondrial respiration and oxidative stress and protects neuronal cell death. Publication Status: Online-Only, [RefSeq, PubMed]; Falnidamol and cisplatin combinational treatment inhibits non-small cell lung cancer (NSCLC) by targeting DUSP26-mediated signal pathways., [RefSeq, PubMed]; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]., [RefSeq]; Upregulation of dual-specificity phosphatase-26 is required for transforming growth factor beta1(TGFbeta1)-induced Epithelial-mesenchymal transition in A549 and PANC1 cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DSV8;Q9BTW0",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;3.1.3.5;3.1.3.2;2.7.10.1;3.1.3.67;3.1.3.53;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0002039 p53 binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045785 positive regulation of cell adhesion;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0006470 protein dephosphorylation;GO:0043409 negative regulation of MAPK cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9BV47-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99684-1",
        "uniprot_id": "GFI1_HUMAN",
        "mass": 45297.0,
        "length": 422,
        "protein_name": "Zinc finger protein Gfi-1",
        "gene_name": "GFI1",
        "organism": "Human",
        "refseq_name": "zinc finger protein Gfi-1",
        "refseq_ac": "NP_001120687",
        "gene_names_uniprotkb": "GFI1; ZNF163",
        "gene_names_refseq": "GFI-1; GFI1A; GFI1; SCN2; ZNF163",
        "protein_names_uniprotkb": "Zinc finger protein Gfi-1; Growth factor independent protein 1; Zinc finger protein 163",
        "protein_names_refseq": "growth factor independence-1; growth factor independent 1 transcription repressor; growth factor independent protein 1; zinc finger protein 163; zinc finger protein Gfi-1",
        "tax_id": 9606,
        "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); myelodysplastic syndrome (Disease Ontology:DOID:0050908); severe congenital neutropenia 2 (Disease Ontology:DOID:0112131); leukemia (Disease Ontology:DOID:1240); alcohol use disorder (Disease Ontology:DOID:1574); acute myeloid leukemia (Disease Ontology:DOID:9119); nonimmune chronic idiopathic neutropenia of adults (MONDO:MONDO:0011922)",
        "pathway": " (hsa:2672);  (R-HSA-9616222)",
        "pathway_count": 2,
        "publication_count": 80,
        "publication_id_list": "10233885;10330422;11060035;11237011;11242107;11340171;11369759;11564866;11684017;11867521;12242300;12702500;12778173;12869508;12874834;14517214;16287849;16751774;17063141;17197705;17562868;17646546;18776924;18805794;19026687;19164764;20190815;20547752;20661648;21471526;21993314;22371011;22474248;23001182;23481700;24379003;24584857;2524830;25548167;25576301;25784653;25880248;26154972;26992070;27080012;2721961;27480105;27846572;28832583;28904123;29242379;29431622;29493099;29557506;29632046;29651020;29786170;30524438;31154438;32387766;32897882;32938616;32983136;33141586;33298915;33392160;33912179;34509645;35051231;35504619;35819844;36010968;37423893;38305289;7862113;8695841;8754800;8846917;9051000;9177240",
        "class_list": "",
        "function": "Combination of the sequence-specific and nonspecific DNA-binding modes of SATB1 should be advantageous in a search for target loci during transcriptional regulation Erratum:[Biochem J. 2017 Aug 11;474(17):2951. doi: 10.1042/BCJ-2016-0558_COR. PMID: 28801480], [RefSeq, PubMed]; DLEU2/EZH2/GFI1 Axis Regulates the Proliferation and Apoptosis of Human Bone Marrow Mesenchymal Stem Cells., [RefSeq, PubMed]; Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells., [RefSeq, PubMed]; GFI1 regulates chromatin state essential in human endothelial-to-haematopoietic transition., [RefSeq, PubMed]; GFI1(36S) homozygous patients exhibited a sustained response to treatment with hypomethylating agents, whereas GFI1(36N) patients had a poor sustained response to this therapy. Because allele status of GFI1(36N) is readily determined using basic molecular techniques, we propose inclusion of GFI1(36N) status in future prospective studies for MDS patients to better predict prognosis and guide therapeutic decisions., [RefSeq, PubMed]; Hematopoietic transcription factor GFI1 promotes anchorage independence by sustaining ERK activity in cancer cells., [RefSeq, PubMed]; Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2, [RefSeq, PubMed]; This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription repressor essential for hematopoiesis (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Functions in a cell-context and development-specific manner (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16287849). Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (PubMed:12778173). Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling (By similarity). Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (PubMed:20547752). Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (PubMed:19026687). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (PubMed:16287849). Required for the maintenance of inner ear hair cells (By similarity). In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response: facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (PubMed:29651020)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N564",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex;GO:0016604 nuclear body;GO:0016363 nuclear matrix",
        "go_biological_process": "GO:0010957 negative regulation of vitamin D biosynthetic process;GO:0070105 positive regulation of interleukin-6-mediated signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 8.1,
        "record_id": "Q99684-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UI26-1",
        "uniprot_id": "IPO11_HUMAN",
        "mass": 112535.0,
        "length": 975,
        "protein_name": "Importin-11",
        "gene_name": "IPO11",
        "organism": "Human",
        "refseq_name": "importin-11 isoform 1",
        "refseq_ac": "NP_001128251",
        "gene_names_uniprotkb": "IPO11; RANBP11",
        "gene_names_refseq": "IPO11; RanBP11",
        "protein_names_uniprotkb": "Importin-11; Imp11; Ran-binding protein 11; RanBP11",
        "protein_names_refseq": "Ran binding protein 11; imp11; importin-11 isoform 1; ran-binding protein 11",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51194)",
        "pathway_count": 1,
        "publication_count": 85,
        "publication_id_list": "10.1101/2023.09.13.557529;11032817;11237011;22424782;23186163;23301498;23481700;24366607;25378586;25418920;25576301;25645385;25880248;25892735;26154972;26375851;26811146;26929215;26992070;27846572;27920218;28063628;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;30315122;30410026;30429286;30484775;30524438;30779550;31154438;31217245;31530632;31844290;31848261;31937595;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33091337;33141586;33298915;33392160;33571591;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34357683;34405274;34509645;34649567;34725712;34932366;35051231;35251023;36010968;36241641;36284347;36581221;40914422",
        "class_list": "",
        "function": "Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that ubiquitin-conjugating enzyme UBE2E3 and importin 11 (Imp-11)promote the nuclear accumulation and activity of transcription factor NF-E2 (Nrf2) by restricting the transcription factor from partitioning to the mitochondria, [RefSeq, PubMed]; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity)., [UniProtKB, PubMed]; Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]., [RefSeq]; The nuclear transporter importin-11 regulates the Wnt/beta-catenin pathway and acts as a tumor promoter in glioma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NGJ5;B4DZ73;D3DW98;Q8N5R2;Q9NSJ6;Q9NVB1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031267 small GTPase binding;GO:0061608 nuclear import signal receptor activity",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "Q9UI26-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P48146-1",
        "uniprot_id": "NPBW2_HUMAN",
        "mass": 36861.0,
        "length": 333,
        "protein_name": "Neuropeptides B/W receptor type 2",
        "gene_name": "NPBWR2",
        "organism": "Human",
        "refseq_name": "neuropeptides B/W receptor type 2",
        "refseq_ac": "NP_005277",
        "gene_names_uniprotkb": "NPBWR2; GPR8",
        "gene_names_refseq": "GPR8; NPBWR2",
        "protein_names_uniprotkb": "Neuropeptides B/W receptor type 2; G protein-coupled receptor 8",
        "protein_names_refseq": "G-protein coupled receptor 8; neuropeptides B/W receptor 2; neuropeptides B/W receptor type 2; opioid-somatostatin-like receptor 8",
        "tax_id": 9606,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:2832);  (R-HSA-375276);  (R-HSA-418594)",
        "pathway_count": 3,
        "publication_count": 109,
        "publication_id_list": "10079109;10100623;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10604470;10854085;10899166;11007482;11322507;11385580;11457843;11562423;11683476;11773063;12120503;12401809;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15539556;1567413;15947423;15951850;1655761;16634148;16923326;16959974;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18577758;23446738;23690594;24906252;2534964;2649896;27399877;2748346;27496565;2834384;29557506;3202875;3366244;3525564;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8015379;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8406495;8440682;8463333;8503909;8615752;8666380;8702752;873923;8823230;9171878;9521323;9530155;9593744;9607765;9685625;9722565;9792798;9832121;9851594",
        "class_list": "",
        "function": "Distribution in central nervous system and peripheral tissues with precursor peptides, [RefSeq, PubMed]; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals., [UniProtKB]; Mainly expressed in brain or pituitary, [RefSeq, PubMed]; The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NWQ6;Q9H4K3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0008188 neuropeptide receptor activity;GO:0042923 neuropeptide binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043005 neuron projection",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 11.0,
        "record_id": "P48146-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P28370-2",
        "uniprot_id": "SMCA1_HUMAN",
        "mass": 121142.0,
        "length": 1042,
        "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1",
        "gene_name": "SMARCA1",
        "organism": "Human",
        "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 isoform c",
        "refseq_ac": "NP_001269804",
        "gene_names_uniprotkb": "SMARCA1; SNF2L1; SNF2L",
        "gene_names_refseq": "ISWI; NURF140; SMARCA1; SNF2L1; SNF2LB; SNF2LT; SNF2L; SWI2; SWI; hSNF2L",
        "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1; 3.6.4.-; Global transcription activator SNF2L1; Nucleosome-remodeling factor subunit SNF2L; SMARCA1; SNF2 related chromatin remodeling ATPase 1; SNF2L; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1",
        "protein_names_refseq": "ATP-dependent helicase SMARCA1; SNF2-like 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 isoform c; global transcription activator SNF2L1; global transcription activator homologous sequence; nucleosome-remodeling factor subunit SNF2L; probable global transcription activator SNF2L1; sucrose nonfermenting 2-like protein 1",
        "tax_id": 9606,
        "disease": "central nervous system disease (Disease Ontology:DOID:331)",
        "pathway": " (hsa:6594)",
        "pathway_count": 1,
        "publication_count": 58,
        "publication_id_list": "10.1101/2023.09.13.557529;12112843;1408766;14609955;15310751;15640247;16740656;17081983;21406692;25755297;26030138;26154972;26740508;26992070;27600516;27920218;28063628;28218747;28514659;28801535;28832583;28834231;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30410026;30922402;31376231;31844290;31848261;32157095;32161166;32522876;32897882;32938616;32983136;33592498;33691108;33968037;34171305;34211107;34509645;34932366;35051231;35580925;36010968;36126083;36241641;36284347;37725664;37938771;39413208",
        "class_list": "",
        "function": "A neuronal SNF2L variant inactivates chromatin remodeling, [RefSeq, PubMed]; A pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomas. Publication Status: Online-Only, [RefSeq, PubMed]; ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751)., [UniProtKB, PubMed, PubMed]; High SNF2L expression is associated with gastric cancer growth and invasion. Publication Status: Online-Only, [RefSeq, PubMed]; The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells., [RefSeq, PubMed]; This gene encodes a member of the SWI/SNF family of proteins. The encoded protein is an ATPase which is expressed in diverse tissues and contributes to the chromatin remodeling complex that is involved in transcription. The protein may also play a role in DNA damage, growth inhibition and apoptosis of cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]., [RefSeq]; This is the first report of an interstitial deletion encompassing OCRL and SMARCA1 gene in Lowe syndrome., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JV41;Q5JV42",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0016589 NURF complex;GO:0090537 CERF complex",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0007420 brain development",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "P28370-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WU79-1",
        "uniprot_id": "SMAP2_HUMAN",
        "mass": 46786.0,
        "length": 429,
        "protein_name": "Stromal membrane-associated protein 2",
        "gene_name": "SMAP2",
        "organism": "Human",
        "refseq_name": "stromal membrane-associated protein 2 isoform 3",
        "refseq_ac": "NP_001185907",
        "gene_names_uniprotkb": "SMAP2; SMAP1L",
        "gene_names_refseq": "SMAP1L; SMAP2",
        "protein_names_uniprotkb": "Stromal membrane-associated protein 2; Stromal membrane-associated protein 1-like",
        "protein_names_refseq": "stromal membrane-associated GTPase-activating protein 2; stromal membrane-associated protein 2 isoform 3; stromal membrane-associated protein 2",
        "tax_id": 9606,
        "disease": "candidiasis (Disease Ontology:DOID:1508)",
        "pathway": " (hsa:64744)",
        "pathway_count": 1,
        "publication_count": 81,
        "publication_id_list": "11237011;18669648;18691976;19651622;19690332;19901323;20058876;20068231;20166139;20230923;20831471;21147065;23186163;23481700;24275569;24715725;25281535;25418920;25576301;25892735;26136365;26154972;26992070;27846572;28218747;28228285;28604694;28657654;28832583;28834231;28904123;29242379;29351928;29493099;29508533;29557506;29632711;29769354;29786170;30315122;30410026;30524438;30779550;31092671;31154438;31217245;31492838;31530632;31844290;31848261;31998317;32119511;32157095;32161166;32350084;32387766;32897882;32983136;33298915;33392160;33633747;33717175;33912179;33968037;34019948;34171305;34509645;34561969;35051231;35154160;35251023;35254053;35318648;35561310;35580925;36010968;36241641;36581221;37938771;38665916;40596516",
        "class_list": "",
        "function": "Analyses revealed that three common polymorphisms, rs2982510, rs2294752, and rs446738, were putatively associated with the increased susceptibility to AIA GeneRIF: Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity)., [UniProtKB]; In the current study, there were identified sequences in the carboxy-terminal region of SMAP2 that are critical for its specific subcellular localization and its specificity for Arf proteins., [RefSeq, PubMed]; Results also demonstrated a physical association between SMAP1 and SMAP2, which might serve as a basis for a functional interaction, and identified the intramolecular domains responsible for this association, [RefSeq, PubMed]; SMAP2 immunoprecipitated clathrin and AP-1 through a putative clathrin-binding domain and a CALM-binding domain, and SMAP2 mutants that did not interact with clathrin or AP-1 could not localize to recycling endosomes, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7T1;B7Z5B5;B7Z8V2;D3DPV2;Q5QPL2;Q96C93;Q9NST2;Q9UJL8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 8.7,
        "record_id": "Q8WU79-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P04155-1",
        "uniprot_id": "TFF1_HUMAN",
        "mass": 9150.0,
        "length": 84,
        "protein_name": "Trefoil factor 1",
        "gene_name": "TFF1",
        "organism": "Human",
        "refseq_name": "trefoil factor 1 precursor",
        "refseq_ac": "NP_003216",
        "gene_names_uniprotkb": "TFF1; BCEI; PS2",
        "gene_names_refseq": "BCEI; D21S21; HP1.A; HPS2; TFF1; pNR-2; pS2",
        "protein_names_uniprotkb": "Trefoil factor 1; Breast cancer estrogen-inducible protein; PNR-2; Polypeptide P1.A; Protein pS2; hP1.A",
        "protein_names_refseq": "breast cancer estrogen-inducible protein; breast cancer estrogen-inducible sequence; gastrointestinal trefoil protein pS2; polypeptide P1.A; trefoil factor 1 precursor",
        "tax_id": 9606,
        "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); colitis (Disease Ontology:DOID:0060180); endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); signet ring cell adenocarcinoma (Disease Ontology:DOID:3493); cervical adenocarcinoma (Disease Ontology:DOID:3702); ovarian carcinoma (Disease Ontology:DOID:4001)",
        "pathway": " (hsa:7031);  (R-HSA-9018519)",
        "pathway_count": 2,
        "publication_count": 161,
        "publication_id_list": "10.1038/emboj.2013.79;10500157;10828826;10830953;10873660;10950923;10982763;11010967;11034064;11103799;11136970;11165043;11286998;11345900;11410592;11452016;11581164;11682626;12498683;12612073;12959972;14631847;14675539;15001666;15276198;15282324;15340161;15343269;15345050;15489334;15514030;15924415;15986123;16009131;16046058;16087863;16113099;1630819;16308573;16697734;16718800;16980581;17013392;1707960;17143957;17242463;17277772;17463000;17495528;17510434;17637753;17666587;17690249;18187655;18219272;18256232;18322535;18358809;18476782;18533032;18762174;18805503;19001364;19020303;19098913;19274700;19295514;19321454;19383337;19718048;20219941;20220130;20498280;20570965;20682797;21106759;21151129;21445275;21573489;2181374;21835891;2185238;21878914;21934649;21940756;22056668;22265404;22492511;22545144;22704330;2303034;2311759;23145106;23172872;23192763;23303788;23403292;23435229;23584533;23723241;23906331;24167369;24371278;24735615;24854081;24885040;24973012;24998469;25296600;25365482;25433557;25542856;25633194;25663755;25674852;25728767;26056233;26153859;26204489;26462610;26479350;27062924;27886276;28539435;2919170;3041593;3045126;3146413;32391824;32404934;3261981;3281094;33249323;33673347;34058470;34087483;3498214;35987613;36057754;36514982;36758349;3677090;37437926;3822834;3838275;6324130;7559524;7935485;7937828;8195246;8197458;8419924;8521850;8876171;9096235;9201922;9338790;9388265;9611253;9671459;9731700",
        "class_list": "",
        "function": "Association of functional genetic variants in TFF1 and nephrolithiasis risk in a Chinese population. Publication Status: Online-Only, [RefSeq, PubMed]; IFNgamma-dependent silencing of TFF1 during Helicobacter pylori infection., [RefSeq, PubMed]; Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]., [RefSeq]; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine., [UniProtKB, PubMed]; Study on TFF1 and PALB2 gene variants associated with gastric carcinoma risk in the Chinese Han population., [RefSeq, PubMed]; TFF1 gene single nucleotide polymorphism (rs3761376) and colorectal cancer risk., [RefSeq, PubMed]; The Transcription Factor RUNX1 Aggravates Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Dysfunction by Negatively Regulating TFF1 Promoter., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 14,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0030277 maintenance of gastrointestinal epithelium;GO:0043434 response to peptide hormone;GO:0010039 response to iron ion;GO:0035902 response to immobilization stress",
        "synthesized_glycan_count": 0,
        "hit_score": 16.4,
        "record_id": "P04155-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5BKZ1-1",
        "uniprot_id": "ZN326_HUMAN",
        "mass": 65654.0,
        "length": 582,
        "protein_name": "DBIRD complex subunit ZNF326",
        "gene_name": "ZNF326",
        "organism": "Human",
        "refseq_name": "DBIRD complex subunit ZNF326 isoform 4",
        "refseq_ac": "NP_001307114",
        "gene_names_uniprotkb": "ZNF326; ZIRD",
        "gene_names_refseq": "ZAN75; ZIRD; ZNF326; Zfp326; dJ871E2.1",
        "protein_names_uniprotkb": "DBIRD complex subunit ZNF326; Zinc finger protein 326; Zinc finger protein interacting with mRNPs and DBC1",
        "protein_names_refseq": "DBIRD complex subunit ZNF326 isoform 4; DBIRD complex subunit ZNF326; ZNF-protein interacting with nuclear mRNPs and DBC1; zinc finger protein interacting with mRNPs and DBC1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284695)",
        "pathway_count": 1,
        "publication_count": 72,
        "publication_id_list": "11237011;16479539;17081983;17287340;17924679;18452278;18669648;18691976;19608861;19651622;19664995;20068231;21406692;22446626;22666313;23186163;23301498;24129315;24275569;24714562;25576301;25645385;25892735;26811146;26992070;27920218;28063628;28218747;28228285;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29557506;29786170;30315122;30397120;30401956;30429286;30444036;30691485;30779550;30833945;31154438;31492838;31844290;31930344;31998317;32157095;32357974;32387766;32488085;32502341;32938616;32983136;33155203;33214551;33912179;33968037;33981976;34019948;34185709;34229054;35051231;35580925;36284347;37938771;38665916;40596516",
        "class_list": "",
        "function": "Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro., [UniProtKB, PubMed]; Data indicate that the DBIRD complex (consisting of DBC1 and ZNF326) acts at the interface between mRNP particles and RNAPII, integrating transcript elongation with the regulation of alternative splicing Publication Status: Online-Only, [RefSeq, PubMed]; High ZNF326 expression is associated with glioma. Erratum:[J Exp Clin Cancer Res. 2020 Jan 16;39(1):14. doi: 10.1186/s13046-020-1526-z. PMID: 31941535] Publication Status: Online-Only, [RefSeq, PubMed]; Involvement of the Zfp326 and ZNF326 genes in antidepressant treatment response, [RefSeq, PubMed]; MicroRNA-136-5p regulates gemcitabine resistance in pancreatic cancer via down-regulating ZNF32., [RefSeq, PubMed]; Studied role of zinc finger protein 326 (ZNF326) in promotion of excision repair cross-complementation group 1 (ERCC1) expression in non-small cell lung cancer (NSCLC) cells., [RefSeq, PubMed]; Transcription Factor ZNF326 Upregulates the Expression of ERCC1 and HDAC7 and its Clinicopathologic Significance in Glioma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 26,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MYX1;B4DLN0;B4E179;Q5VW93;Q5VW94;Q5VW96;Q5VW97;Q6NSA2;Q7Z638;Q7Z6C2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0016363 nuclear matrix;GO:0044609 DBIRD complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006355 regulation of DNA-templated transcription;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing",
        "synthesized_glycan_count": 0,
        "hit_score": 7.6,
        "record_id": "Q5BKZ1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H270-1",
        "uniprot_id": "VPS11_HUMAN",
        "mass": 107809.0,
        "length": 941,
        "protein_name": "Vacuolar protein sorting-associated protein 11 homolog",
        "gene_name": "VPS11",
        "organism": "Human",
        "refseq_name": "vacuolar protein sorting-associated protein 11 homolog isoform 2",
        "refseq_ac": "NP_001277114",
        "gene_names_uniprotkb": "VPS11; PP3476; RNF108",
        "gene_names_refseq": "DYT32; END1; HLD12; PEP5; RNF108; VPS11; hVPS11",
        "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 11 homolog; RING finger protein 108; hVPS11",
        "protein_names_refseq": "RING finger protein 108; VPS11, CORVET/HOPS core subunit; vacuolar protein sorting 11 homolog; vacuolar protein sorting-associated protein 11 homolog isoform 2; vacuolar protein sorting-associated protein 11 homolog",
        "tax_id": 9606,
        "disease": "hypomyelinating leukoencephalopathy (Disease Ontology:DOID:0050987); hypomyelinating leukodystrophy 12 (Disease Ontology:DOID:0060796); dystonia 32 (Disease Ontology:DOID:0060939)",
        "pathway": " (hsa:55823);  (R-HSA-9754560)",
        "pathway_count": 2,
        "publication_count": 90,
        "publication_id_list": "11237011;11250079;11382755;15498874;17897319;19413330;20434987;20682791;21148287;21802320;22223895;23186163;23351085;23481700;23593995;23901104;24366607;24554770;24715725;25266290;25418920;25576301;25783203;25880248;25892735;26154972;26307567;26992070;27600516;27846572;27920218;28063628;28218747;28325809;28514659;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29632711;29769354;29786170;30379171;30410026;30524438;31154438;31217245;31222486;31530632;31844290;31848261;32157095;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33314660;33422265;33452836;33592498;33717175;33912179;33947832;33966045;33968037;34087483;34357683;34386498;34509645;34932366;35051231;35580925;35662671;36010968;36241641;36284347;36581221;37217939;38253038",
        "class_list": "",
        "function": "Overexpression of VPS11 antagonizes the promoting effect of miR-542-3p on Mycobacterium tuberculosis survival in macrophages by regulating autophagy., [RefSeq, PubMed]; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WXL6;Q8WY89;Q96EP8;Q9H6D9;Q9HCS6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0000166 nucleotide binding;GO:0019905 syntaxin binding",
        "go_cellular_component": "GO:0030897 HOPS complex;GO:0005768 endosome;GO:0005769 early endosome;GO:0005764 lysosome;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0048284 organelle fusion;GO:1902115 regulation of organelle assembly;GO:0035542 regulation of SNARE complex assembly;GO:0006886 intracellular protein transport;GO:1903955 positive regulation of protein targeting to mitochondrion",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "Q9H270-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HCE1-1",
        "uniprot_id": "MOV10_HUMAN",
        "mass": 113671.0,
        "length": 1003,
        "protein_name": "RNA helicase MOV-10",
        "gene_name": "MOV10",
        "organism": "Human",
        "refseq_name": "helicase MOV-10 isoform 1",
        "refseq_ac": "NP_001123551",
        "gene_names_uniprotkb": "MOV10; KIAA1631",
        "gene_names_refseq": "MOV10; fSAP113; gb110",
        "protein_names_uniprotkb": "RNA helicase MOV-10; 5.6.2.5; Armitage homolog; Moloney leukemia virus 10 protein; RNA 5'-3' helicase MOV-10",
        "protein_names_refseq": "Mov10 RISC complex RNA helicase; Mov10, Moloney leukemia virus 10, homolog; armitage homolog; functional spliceosome-associated protein 113; helicase MOV-10 isoform 1; moloney leukemia virus 10 protein; putative helicase MOV-10",
        "tax_id": 9606,
        "disease": "hypertension (Disease Ontology:DOID:10763)",
        "pathway": " (hsa:4343);  (R-HSA-165159);  (R-HSA-1912408);  (R-HSA-2559580);  (R-HSA-2559585);  (R-HSA-4086398);  (R-HSA-5628897);  (R-HSA-5687128);  (R-HSA-8853884);  (R-HSA-8934593);  (R-HSA-8936459);  (R-HSA-8943723);  (R-HSA-8948700);  (R-HSA-8948747);  (R-HSA-8986944);  (R-HSA-9018519);  (R-HSA-9022692);  (R-HSA-9029569);  (R-HSA-9725371);  (R-HSA-9759811);  (R-HSA-9764562);  (R-HSA-9768778);  (R-HSA-9824594);  (R-HSA-9839394);  (R-HSA-9909620)",
        "pathway_count": 25,
        "publication_count": 660,
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        "class_list": "",
        "function": "(Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription., [UniProtKB, PubMed]; 5'-3' RNA helicase (PubMed:24726324). Involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; MOV10 recruits DCP2 to decap human LINE-1 RNA by forming large cytoplasmic granules with phase separation properties., [RefSeq, PubMed]; Mov10 coimmunoprecipitates with human Ago1 and Ago2 and also colocalizes with them in cytoplasmic P-bodies., [RefSeq, PubMed]; S100A16 stabilizes the ITGA3-mediated ECM-receptor interaction pathway to drive the malignant properties of lung adenocarcinoma cells via binding MOV10., [RefSeq, PubMed]; The identification of capped small RNAs and the involvement of MOV10 in hepatitis delta virus replication further suggest a conserved mechanism related to RNA-directed transcription in lower eukaryotes., [RefSeq, PubMed]; These data suggest that MOV10 is involved in the progression of telomerase-catalyzing reaction via the interaction of telomerase protein and telomere DNA., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JR03;Q8TEF0;Q9BSY3;Q9BUJ9",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;2.1.1.364;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;7.6.2.1;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;2.1.1.37;3.4.21.53;5.6.2.5;2.7.10.2;2.7.11.1;3.1.-.-;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.6.5.-;2.1.1.-;2.3.1.48;2.3.1.-;3.5.1.-;3.5.1.98;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;3.6.1.15;3.1.4.-;2.3.1.57;3.6.-.-;2.1.1.319;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;3.1.26.n2;2.7.11.24;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0032574 5'-3' RNA helicase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0051607 defense response to virus;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0035279 miRNA-mediated gene silencing by mRNA destabilization;GO:0035195 miRNA-mediated post-transcriptional gene silencing",
        "synthesized_glycan_count": 0,
        "hit_score": 66.3,
        "record_id": "Q9HCE1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P203-1",
        "uniprot_id": "BTBD7_HUMAN",
        "mass": 126368.0,
        "length": 1132,
        "protein_name": "BTB/POZ domain-containing protein 7",
        "gene_name": "BTBD7",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing protein 7 isoform 1",
        "refseq_ac": "NP_001002860",
        "gene_names_uniprotkb": "BTBD7; KIAA1525",
        "gene_names_refseq": "BTBD7; FUP1",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein 7",
        "protein_names_refseq": "BTB (POZ) domain containing 7; BTB/POZ domain-containing protein 7 isoform 1; BTB/POZ domain-containing protein 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55727)",
        "pathway_count": 1,
        "publication_count": 52,
        "publication_id_list": "11237011;19413330;20213681;23186163;23325674;23481700;24714562;25253020;25576301;26375851;26728094;26768311;26992070;27540976;27983936;28832583;28834231;28904123;29242379;29557506;30429286;30779550;31154438;31303496;31530632;31844290;31848261;31886230;32157095;32357974;32387766;32488085;32502341;32772271;32897882;32938616;32983136;33717175;33936100;33968037;33981976;34087483;34211107;34509645;34932366;35051231;35580925;35655918;36010968;36241641;36284347;37050886",
        "class_list": "",
        "function": "Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity)., [UniProtKB]; BTB domain-containing 7 predicts low recurrence and suppresses tumor progression by deactivating Notch1 signaling in breast cancer., [RefSeq, PubMed]; BTBD7 expression was significantly correlated with Slug expression in SACC (P< 0.05). Increased BTBD7 expression was significantly associated with the TNM stage, tissue typing, distant metastasis and patients' poor clinical outcome., [RefSeq, PubMed]; Btbd7 contributes to reduced expression of E-cadherin and may be a promising cancer marker in non-small cell lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Cox regression analysis revealed that high BTBD7 expression integrated with high microvessel density was a powerful independent predictive factor of hepatocellular carcinoma clinical outcome., [RefSeq, PubMed]; Extracellular Vesicles Carrying miR-887-3p Promote Breast Cancer Cell Drug Resistance by Targeting BTBD7 and Activating the Notch1/Hes1 Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Our data indicate that detection of high miR-23b and Btbd7 levels in the primary tumor of CRC patients can be correlated with the development of cancer metastasis and thus patients with these biological features should be treated more aggressively and have closer follow-ups., [RefSeq, PubMed]; Silencing of Btbd7 significantly inhibited the self-renewal and EMT process in CD133+ cells. we found that downregulation of Btbd7 promoted cell apoptosis and increased the sensitivity to paclitaxel in CD133+ and parental cells., [RefSeq, PubMed]; Studied the role of BTB domain containing 7 (BTBD7) in regulation of E-Cadherin in the development of lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The Role of BTBD7 in Normal Development and Tumor Progression. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5V7;Q69Z05;Q7Z308;Q86TS0;Q9HAA4;Q9NVM0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0061138 morphogenesis of a branching epithelium;GO:0060693 regulation of branching involved in salivary gland morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q9P203-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y4Z0-1",
        "uniprot_id": "LSM4_HUMAN",
        "mass": 15350.0,
        "length": 139,
        "protein_name": "U6 snRNA-associated Sm-like protein LSm4",
        "gene_name": "LSM4",
        "organism": "Human",
        "refseq_name": "U6 snRNA-associated Sm-like protein LSm4 isoform 1",
        "refseq_ac": "NP_036453",
        "gene_names_uniprotkb": "LSM4",
        "gene_names_refseq": "GRP; LSM4; YER112W",
        "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm4; GRP; Glycine-rich protein",
        "protein_names_refseq": "LSM4 U6 small nuclear RNA and mRNA degradation associated; LSM4 homolog, U6 small nuclear RNA associated; U6 snRNA-associated Sm-like protein LSm4 isoform 1; U6 snRNA-associated Sm-like protein LSm4; glycine-rich protein",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162); atherosclerosis (Disease Ontology:DOID:1936)",
        "pathway": " (hsa:25804);  (R-HSA-430039);  (R-HSA-72163)",
        "pathway_count": 3,
        "publication_count": 140,
        "publication_id_list": "10369684;10523320;10882114;10931946;11014198;11101529;11233976;11237011;11283721;11991638;12176931;12218187;12411573;12414731;12417715;12477934;12486012;12515382;12923261;14625303;14713954;14749774;15085179;15231747;15475613;15711010;16051491;16141059;16246173;16299471;16314458;16809785;17095540;17245413;17332742;17606899;18039849;18322460;18593880;19061636;19103666;19165350;19239894;19279404;19536130;20112406;20423332;20980672;21536652;2176635;22110043;22365833;22959432;22961380;23222130;23236153;23345524;23481700;24196718;24304693;24448447;24737827;24914973;25418920;25555158;2558966;25645385;26385511;26420826;26912367;26969736;26992070;27377154;27459055;27600516;27683217;27920218;28062851;28076346;28228285;28502770;28514659;28781166;28832583;28904123;29242379;29301961;29331515;29360106;29361316;29393594;29557506;29632046;2963332;29789417;30315277;30484775;30524438;30705154;30728453;30765414;30975767;31154438;31217245;31409651;31844290;32157095;32179686;32329775;32488085;32494006;33243851;33446560;33592498;33912179;33968037;34019948;34301950;34357683;34822310;35008409;35051231;35385551;35561310;35580925;36976747;3757028;37938771;38462740;38665916;8566756;8608946;9016565;9242493;9512519;9524131;9539711;9671485;9701291;9731529",
        "class_list": "",
        "function": "Binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; METTL3-mediated the m6A modification of SF3B4 facilitates the development of non-small cell lung cancer by enhancing LSM4 expression., [RefSeq, PubMed]; Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]., [RefSeq]; [Phase Separation of Purified Human LSM4 Protein]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0042731 PH domain binding;GO:0017070 U6 snRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0008380 RNA splicing;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 14.3,
        "record_id": "Q9Y4Z0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q76B58-1",
        "uniprot_id": "BRNP3_HUMAN",
        "mass": 88445.0,
        "length": 766,
        "protein_name": "BMP/retinoic acid-inducible neural-specific protein 3",
        "gene_name": "BRINP3",
        "organism": "Human",
        "refseq_name": "BMP/retinoic acid-inducible neural-specific protein 3 isoform 2",
        "refseq_ac": "NP_001304117",
        "gene_names_uniprotkb": "BRINP3; DBCCR1L1; DBCCR1L; FAM5C",
        "gene_names_refseq": "BRINP3; DBCCR1L1; DBCCR1L; FAM5C",
        "protein_names_uniprotkb": "BMP/retinoic acid-inducible neural-specific protein 3; DBCCR1-like protein 1",
        "protein_names_refseq": "BMP/retinoic acid-inducible neural-specific protein 3 isoform 2; BMP/retinoic acid-inducible neural-specific protein 3; DBCCR1-like protein 1; bone morphogenetic protein/retinoic acid inducible neural-specific 3; family with sequence similarity 5, member C; protein FAM5C",
        "tax_id": 9606,
        "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); aggressive periodontitis (Disease Ontology:DOID:1474); periodontal disease (Disease Ontology:DOID:3388); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); myocardial infarction (Disease Ontology:DOID:5844); ulcerative colitis (Disease Ontology:DOID:8577)",
        "pathway": " (hsa:339479)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;17138656;17903301;18430236;19787213;25887438;26717922;27461004;27836731;28351617;29393594;31844290;35051231",
        "class_list": "",
        "function": "BRINP3 is a mitochondrially localized protein that is selectively up-regulated in human gonadotropinomas; its actions to increase proliferation, migration, and invasion suggest it may play an important role in pituitary tumorigenesis, [RefSeq, PubMed]; Data show that all the six inflammation-related CpG-SNPs genotypes including IL1B rs16944, IL1R2 rs2071008, PLA2G7 rs9395208, FAM5C rs12732361, CD40 rs1800686, and CD36 rs2065666 were associated with coronary heart disease (CHD), suggesting an important role of inflammation in the risk of CHD. Publication Status: Online-Only, [RefSeq, PubMed]; FAM5C is a risk factor for cerebral infarction in type 2 diabetic patients., [RefSeq, PubMed]; Genome-wide association study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development., [UniProtKB, PubMed]; Study provides evidence that the BRINP3 polymorphic variant rs1342913 and low level of BRINP3 expression are associated with peri-implantitis, independently from the presence of chronic periodontitis. Publication Status: Online-Only, [RefSeq, PubMed]; The association of serum OGN and FAM5C levels and muscle mass with bone mineral density (BMD), bone turnover markers, and the presence of vertebral fractures (VFs) in 156 postmenopausal women with type 2 diabetes mellitus, is reported., [RefSeq, PubMed]; The results demonstrated that FAM5C is an N-glycosylated protein, and N-glycosylation by UGGT1 is necessary for the secretion of FAM5C., [RefSeq, PubMed]; These data implicate FAM5C alleles in the risk of myocardial infarction and suggest further functional studies of FAM5C are required to identify the gene's contribution to atherosclerosis GeneRIF: Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 5,
        "mined_n_glycosites": 5,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 84,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 7,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVP1;B7Z260;O95726;Q2M330",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030425 dendrite;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0045666 positive regulation of neuron differentiation;GO:0071300 cellular response to retinoic acid;GO:0045930 negative regulation of mitotic cell cycle;GO:0021953 central nervous system neuron differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q76B58-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UX41-1",
        "uniprot_id": "BTNL8_HUMAN",
        "mass": 56748.0,
        "length": 500,
        "protein_name": "Butyrophilin-like protein 8",
        "gene_name": "BTNL8",
        "organism": "Human",
        "refseq_name": "butyrophilin-like protein 8 isoform 2 precursor",
        "refseq_ac": "NP_001035552",
        "gene_names_uniprotkb": "BTNL8; PRO1347",
        "gene_names_refseq": "BTN9.2; BTNL8",
        "protein_names_uniprotkb": "Butyrophilin-like protein 8",
        "protein_names_refseq": "B7-H5 costimulatory molecule; butyrophilin-like protein 8 isoform 2 precursor; butyrophilin-like protein 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79908);  (R-HSA-8851680)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "11237011;12502743;12975309;15340161;16751379;17785817;19531472;19664994;20208008;20944003;23481700;24036152;24703779;24715725;25637025;25657647;27543614;29557506;29789417;31154438;32375678;32387766;32488085;32502341;34185709;34509645;35051231;36215666",
        "class_list": "",
        "function": "Analysis of genomic information from multiple non-cancer cohorts showed that both the NEGR1 promoter deletion and the BTNL3-8 deletion were CNVs occurring at high frequencies in the general population. Intriguingly, the upstream NEGR1 CNV deletion was homozygous in ~ 40% of individuals in the non-cancer population. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that butyrophilin-like molecule BTNL8 may play an essential role in priming of naive T lymphocytes., [RefSeq, PubMed]; May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4QMZ8;A6NEX6;B7Z409;B7Z5B1;E9PEF6;E9PG07;F2Z2B2;F8W712;Q9H730",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0045062 extrathymic T cell selection;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0001817 regulation of cytokine production",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q6UX41-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UII6-1",
        "uniprot_id": "DS13B_HUMAN",
        "mass": 22149.0,
        "length": 198,
        "protein_name": "Dual specificity protein phosphatase 13B",
        "gene_name": "DUSP13B",
        "organism": "Human",
        "refseq_name": "dual specificity protein phosphatase 13B isoform 2",
        "refseq_ac": "NP_001007273",
        "gene_names_uniprotkb": "DUSP13B; DUSP13; SKRP4; TMDP",
        "gene_names_refseq": "DUSP13B; DUSP13; MDSP; SKRP4; TMDP",
        "protein_names_uniprotkb": "Dual specificity protein phosphatase 13B; 3.1.3.16; 3.1.3.48; Dual specificity phosphatase SKRP4; Testis- and skeletal-muscle-specific DSP",
        "protein_names_refseq": "Testis- and skeletal muscle-specific DUSP; dual specificity phosphatase 13; dual specificity protein phosphatase 13B isoform 2; dual specificity protein phosphatase 13B; testis- and skeletal-muscle-specific DSP",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51207)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "10585869;11237011;15252030;16385451;17044055;21360282;34087483;35051231;35338857;36524545",
        "class_list": "",
        "function": "Data suggest an important role for DUSP13B in protection from external stress during spermatogenesis, [RefSeq, PubMed]; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate., [UniProtKB, UniProtKB, UniProtKB]; Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Here, we report the crystal structure of human TMDP at a resolution of 2.4 A. In spite of high sequence similarity with other DSPs, the crystal structure of TMDP shows distinct structural motifs and surface propertie, [RefSeq, PubMed]; Identified a gene on chromosome 10q22.2 using alternative ORFs to encode two distinct DSPs: the testis and skeletal muscle-specific TMDP and a novel muscle-restricted DSP(MDSP), [RefSeq, PubMed]; Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This gene encodes a dual specificity phosphatase that acts on both phosphotyrosine and phosphoserine/threonine residues. The encoded protein is expressed in testis. [provided by RefSeq, Mar 2023]., [RefSeq]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Overexpression of dual-specificity phosphatases 4 and 13 attenuates transforming growth factor beta1-induced migration and drug resistance in A549 cells in vitro., [RefSeq, PubMed]; Systemic analysis identifying PVT1/DUSP13 axis for microvascular invasion in hepatocellular carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A024QZR6;A8K776;A8K782;B3KPY1;B3KXT0;B4DUK0;Q5JSC6;Q6IAR0;Q96GC2;U3KQ82",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;3.1.3.5;3.1.3.2;2.7.10.1;3.1.3.67;3.1.3.53;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0033549 MAP kinase phosphatase activity;GO:0004725 protein tyrosine phosphatase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0016311 dephosphorylation;GO:0007283 spermatogenesis;GO:0006470 protein dephosphorylation;GO:0043409 negative regulation of MAPK cascade;GO:0051321 meiotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q9UII6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MXD5-1",
        "uniprot_id": "GRCR1_HUMAN",
        "mass": 32294.0,
        "length": 290,
        "protein_name": "Glutaredoxin domain-containing cysteine-rich protein 1",
        "gene_name": "GRXCR1",
        "organism": "Human",
        "refseq_name": "glutaredoxin domain-containing cysteine-rich protein 1",
        "refseq_ac": "NP_001073945",
        "gene_names_uniprotkb": "GRXCR1; DFNB25",
        "gene_names_refseq": "DFNB25; GRXCR1; PPP1R88",
        "protein_names_uniprotkb": "Glutaredoxin domain-containing cysteine-rich protein 1",
        "protein_names_refseq": "glutaredoxin domain-containing cysteine-rich protein 1; glutaredoxin, cysteine rich 1; protein phosphatase 1, regulatory subunit 88",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness 25 (Disease Ontology:DOID:0110483)",
        "pathway": " (hsa:389207);  (R-HSA-9662360);  (R-HSA-9662361)",
        "pathway_count": 3,
        "publication_count": 8,
        "publication_id_list": "10025409;10821263;11163272;20137774;20137778;25802247;28228285;29557506",
        "class_list": "",
        "function": "May play a role in actin filament architecture in developing stereocilia of sensory cells., [UniProtKB]; Novel mutations in GRXCR1 at DFNB25 leading to progressive hearing loss are identified in a Japanese family., [RefSeq, PubMed]; Quantitative analysis of GRXCR1 transcripts in fetal and adult human tissues revealed a preferential expression of the gene in fetal cochlea, which may explain the nonsyndromic nature of the hearing impairment., [RefSeq, PubMed]; This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells. [provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005902 microvillus;GO:0060091 kinocilium;GO:0032420 stereocilium",
        "go_biological_process": "GO:0060118 vestibular receptor cell development;GO:0007605 sensory perception of sound;GO:0060119 inner ear receptor cell development;GO:0060122 inner ear receptor cell stereocilium organization",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "A8MXD5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q04759-1",
        "uniprot_id": "KPCT_HUMAN",
        "mass": 81865.0,
        "length": 706,
        "protein_name": "Protein kinase C theta type",
        "gene_name": "PRKCQ",
        "organism": "Human",
        "refseq_name": "protein kinase C theta type isoform 2",
        "refseq_ac": "NP_001229342",
        "gene_names_uniprotkb": "PRKCQ; PRKCT",
        "gene_names_refseq": "PRKCQ; PRKCT; nPKC-theta",
        "protein_names_uniprotkb": "Protein kinase C theta type; 2.7.11.13; nPKC-theta",
        "protein_names_refseq": "protein kinase C theta type isoform 2; protein kinase C theta type",
        "tax_id": 9606,
        "disease": "hyperinsulinism (Disease Ontology:DOID:2018); prostate adenocarcinoma (Disease Ontology:DOID:2526); retinal detachment (Disease Ontology:DOID:5327)",
        "pathway": " (hsa:5588);  (R-HSA-111465);  (R-HSA-114508);  (R-HSA-202424);  (R-HSA-2514859);  (R-HSA-2871837);  (R-HSA-373752);  (R-HSA-418597);  (R-HSA-8936459);  (R-HSA-9648002)",
        "pathway_count": 10,
        "publication_count": 291,
        "publication_id_list": "10037746;10051575;10085068;10085069;10200466;10453075;10490026;10564809;10617663;10636891;10652356;10667208;10676965;10698680;10702308;10716940;10838074;10882101;10954748;11038283;11080611;11090634;11106668;11120601;11196150;11278797;11292825;11313909;11313965;11325957;11342610;11358993;11413485;11460167;11463840;11585916;11601986;11687658;11713293;11739732;11741893;11754336;11772397;11805119;11861617;11884229;12036349;12107159;12119397;12120503;12154370;12433685;12473184;12483298;12499365;12576332;12660731;12668660;12727204;12750467;12825937;1347957;1356371;1379636;1387789;1436039;14514672;14561760;14660603;14702087;14966563;14988727;15122200;15125833;15145317;15254234;15282562;15327770;15364919;15364937;15371334;15451670;15541657;15659645;15946941;15951850;16000296;16043511;16056267;16123041;16186825;16252004;16274222;16356853;16356855;16356856;16483930;16612002;16628190;16709830;16762451;16831874;16895762;16908407;16923326;16978534;16983089;17047224;17072321;17114291;17135271;17158449;17174565;17192257;17297457;17344846;17363905;17428801;17468049;17496917;17544292;17548359;17636946;17728323;17948050;18055570;18182391;18316480;18328786;18434541;18502828;18577758;18691976;18772140;18803695;19033211;19114653;19188362;19369195;1939224;19509293;19549985;19651622;19690332;19818506;1999465;20230923;20300203;20339092;20416930;20418879;20430952;20622895;20685844;20802526;20876458;20975703;21129147;21170358;21252065;21406692;21661760;21725049;2175712;21779505;21795397;21905185;21905186;21944869;21964608;21966355;21983831;22002721;22144181;22179043;22195972;22330070;22589270;22658984;22721555;22777353;22798961;23186163;23509302;23514631;23698361;23943869;24033119;24275569;24556848;24725411;24971579;25000980;2540796;2550422;25550383;2558719;25638159;25713064;25759176;25781681;25810538;26010396;26085527;26154972;26590425;2661017;26701913;26706195;26771141;2682646;27094677;27396271;27410739;27633441;27697864;27791178;27862975;28167504;28394935;28502923;28630138;28666118;28778966;29242379;29311131;29424242;29493099;29557506;29632711;29786170;3006923;3164688;31844290;32600444;32877642;32983136;33576006;35051231;35132862;35447530;35580925;35705054;36010968;36040231;36969236;38513140;4772407;6264430;7479848;7525588;7526403;7559455;7595566;7644482;7670478;7678445;7682292;7686153;7777544;7937899;7983048;8444877;8494894;8550590;8601309;8626439;8657160;8706659;8812493;8976194;9119368;9252186;9252332;9325343;9353336;9362451;9430683;9431985;9436858;9459445;9506952;9601053;9687533;9810004;9822558;9851253;9858595;9930701;9973322;9990853",
        "class_list": "",
        "function": "Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation (PubMed:21964608). Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Crocin attenuates NF-kappaB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ., [RefSeq, PubMed]; Crosstalk between miR-203 and PKCtheta regulates breast cancer stem cell markers., [RefSeq, PubMed]; PD1 inhibits PKCtheta;-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation., [RefSeq, PubMed]; Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]., [RefSeq]; The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C theta; via a critical Phospho-Thr-Pro motif in the V3 regulatory domain. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DF52;Q14DH6;Q3MJF1;Q64FY5;Q9H508;Q9H549",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;3.4.22.56;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.23;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;3.4.22.-;2.7.1.150",
        "go_molecular_function": "GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0034451 centriolar satellite;GO:0001772 immunological synapse",
        "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0032740 positive regulation of interleukin-17 production;GO:2000570 positive regulation of T-helper 2 cell activation;GO:0006509 membrane protein ectodomain proteolysis;GO:0006954 inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 29.5,
        "record_id": "Q04759-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NPG2-1",
        "uniprot_id": "NGB_HUMAN",
        "mass": 16933.0,
        "length": 151,
        "protein_name": "Neuroglobin",
        "gene_name": "NGB",
        "organism": "Human",
        "refseq_name": "neuroglobin",
        "refseq_ac": "NP_067080",
        "gene_names_uniprotkb": "NGB",
        "gene_names_refseq": "NGB",
        "protein_names_uniprotkb": "Neuroglobin; 1.7.-.-; Nitrite reductase",
        "protein_names_refseq": "neuroglobin; nitrite reductase",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); retinal ischemia (Disease Ontology:DOID:12510); transient cerebral ischemia (Disease Ontology:DOID:224); encephalitis (Disease Ontology:DOID:9588)",
        "pathway": " (hsa:58157);  (R-HSA-8981607)",
        "pathway_count": 2,
        "publication_count": 31,
        "publication_id_list": "11029004;11429401;11473128;11820779;11893755;11919282;12239161;12351835;12860983;12962627;13584010;14530264;15036292;15299006;15601759;18302932;18718500;19919085;20675544;21296891;21965683;22787149;23160832;23195625;24699645;33924212;34440755;34943907;37141638;38092682;5032105",
        "class_list": "",
        "function": "An examination of the protein's structure by crystallization and x-ray diffraction, [RefSeq, PubMed]; Expression is induced by hemin in neural cells, [RefSeq, PubMed]; Full-length cDNA cloning and genomic organization of NGB have been reported., [RefSeq, PubMed]; Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide (PubMed:11473128, PubMed:12962627, PubMed:24699645). Could help transport oxygen and increase its availability to the metabolically active neuronal tissues, though its low quantity in tissues as well as its high affinity for dioxygen, which may limit its oxygen-releasing ability, argue against it (PubMed:11473128, PubMed:12860983, PubMed:12962627, PubMed:24699645). The ferrous/deoxygenated form exhibits a nitrite reductase activity and it could produce nitric oxide which in turn inhibits cellular respiration in response to hypoxia (PubMed:21296891). In its ferrous/deoxygenated state, it may also exhibit GDI (Guanine nucleotide Dissociation Inhibitor) activity toward heterotrimeric G-alpha proteins, thereby regulating signal transduction to facilitate neuroprotective responses in the wake of hypoxia and associated oxidative stress (PubMed:12860983, PubMed:18302932)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Neuroglobin inhibits pancreatic cancer proliferation and metastasis by targeting the GNAI1/EGFR/AKT/ERK signaling axis., [RefSeq, PubMed]; Neuroglobin: A New Possible Marker of Estrogen-Responsive Breast Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression of Neuroglobin Promotes Energy Metabolism and Autophagy Induction in Human Neuroblastoma SH-SY5Y Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Prognostic Values Serum Cav-1 and NGB Levels in Early Neurological Deterioration After Intravenous Thrombolysis in Patients with Acute Ischemic Stroke., [RefSeq, PubMed]; Proteomic and Bioinformatic Investigation of Altered Pathways in Neuroglobin-Deficient Breast Cancer Cells. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "1.11.1.-;1.7.-.-;1.15.1.1;1.14.12.-",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0005092 GDP-dissociation inhibitor activity;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity",
        "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0001666 response to hypoxia;GO:0071456 cellular response to hypoxia;GO:0015671 oxygen transport",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q9NPG2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZVN8-1",
        "uniprot_id": "RGMC_HUMAN",
        "mass": 45080.0,
        "length": 426,
        "protein_name": "Hemojuvelin",
        "gene_name": "HJV",
        "organism": "Human",
        "refseq_name": "hemojuvelin isoform c",
        "refseq_ac": "NP_001303696",
        "gene_names_uniprotkb": "HJV; HFE2; RGMC",
        "gene_names_refseq": "HFE2A; HFE2; HJV; JH; RGMC",
        "protein_names_uniprotkb": "Hemojuvelin; Hemochromatosis type 2 protein; Hemojuvelin BMP coreceptor; RGM domain family member C",
        "protein_names_refseq": "RGM domain family member C; haemojuvelin; hemochromatosis type 2 (juvenile); hemochromatosis type 2 protein; hemojuvelin BMP coreceptor; hemojuvelin isoform c; repulsive guidance molecule c",
        "tax_id": 9606,
        "disease": "hemochromatosis type 2A (Disease Ontology:DOID:0111027); hemochromatosis (Disease Ontology:DOID:2352)",
        "pathway": " (hsa:148738);  (R-HSA-373752)",
        "pathway_count": 2,
        "publication_count": 21,
        "publication_id_list": "11237011;12154370;14647275;14982867;14982873;15461631;16604073;16762451;17174565;18976966;19357398;25156943;25666510;28411811;31307288;32357974;32983136;34946929;35051231;35225679;9858595",
        "class_list": "",
        "function": "Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed:18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed:18976966)., [UniProtKB, PubMed]; Estimates of West African Ancestry in African Americans Using Alleles of Iron-Related Genes HJV, SLC40A1, and TFR2., [RefSeq, PubMed]; Here we report the positional cloning of the locus associated with juvenile hemochromatosis and the identification of a new gene crucial to iron metabolism., [RefSeq, PubMed]; New Mutations in HFE2 and TFR2 Genes Causing Non HFE-Related Hereditary Hemochromatosis. Publication Status: Online-Only, [RefSeq, PubMed]; The functional role of hemojuvelin in acute ischemic stroke., [RefSeq, PubMed]; The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015]., [RefSeq]; The study demonstrates that the two upstream open reading frames (with 28 and 19 codons) present in the 5' UTR of the human HJV mRNA have the ability to significantly decrease translational efficiency under normal conditions., [RefSeq, PubMed]; Various amino acid substitutions identified in hemochromatosis., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1ALI7;Q2PQ63;Q6IMF6;Q8NAH2;Q8WVJ5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:0036122 BMP binding;GO:1990459 transferrin receptor binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0098797 plasma membrane protein complex;GO:1990712 HFE-transferrin receptor complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006879 intracellular iron ion homeostasis;GO:0030509 BMP signaling pathway;GO:0032924 activin receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q6ZVN8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H7L9-1",
        "uniprot_id": "SDS3_HUMAN",
        "mass": 38136.0,
        "length": 328,
        "protein_name": "Sin3 histone deacetylase corepressor complex component SDS3",
        "gene_name": "SUDS3",
        "organism": "Human",
        "refseq_name": "sin3 histone deacetylase corepressor complex component SDS3",
        "refseq_ac": "NP_071936",
        "gene_names_uniprotkb": "SUDS3; SAP45; SDS3",
        "gene_names_refseq": "SAP45; SDS3; SUDS3",
        "protein_names_uniprotkb": "Sin3 histone deacetylase corepressor complex component SDS3; 45 kDa Sin3-associated polypeptide; Suppressor of defective silencing 3 protein homolog",
        "protein_names_refseq": "45 kDa Sin3-associated polypeptide; SDS3 homolog, SIN3A corepressor complex component; sin3 histone deacetylase corepressor complex component SDS3; sin3A-associated protein, 45kDa; suppressor of defective silencing 3 protein homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64426);  (R-HSA-3214815);  (R-HSA-427413);  (R-HSA-5689880);  (R-HSA-9679191)",
        "pathway_count": 5,
        "publication_count": 166,
        "publication_id_list": "10087012;10444327;10444591;10449787;10471499;10748112;10904264;10922406;10926844;10982817;11214971;11509652;11566882;11739383;11742974;11909966;11923872;12032298;12670868;12724404;12917689;12917691;14610093;14661020;15053880;15489224;15916963;16115318;16214042;16522641;16901786;16964248;17081983;17211407;17287340;17290220;17355984;17443180;17662961;17873522;17980597;17981138;18172164;18318008;18467330;18632802;18636086;18669648;19015242;19135894;19188362;19363159;19398555;19415658;19424180;19651622;19690332;19838211;19838300;19874889;19910467;20068231;20096447;20166139;20223979;20228808;20230923;20368735;20501646;21239494;21362556;21406692;21571647;21587264;21596315;21659512;21849505;21962518;22029577;22085928;22128162;22216260;22401777;22552008;22814904;22984288;23159851;23186163;23395819;23481700;23486064;23641311;23824326;23825189;24029068;24056413;24260525;24272870;24275569;24493797;24584101;24896179;25197364;25218447;25305019;25576301;25578727;25755297;25801024;25805136;25880248;25916849;26002965;26101246;26154972;26375851;26992070;27600516;27846572;27920218;28425720;28832583;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29945920;30201761;30410026;30429286;30524438;31048504;31844290;32157095;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33592498;33691108;33717175;33968037;34019948;34211107;34405274;34509645;35051231;35580925;36010968;36215666;37340703;40596516;7513682;7578059;7597036;9150135;9651585;9790534",
        "class_list": "",
        "function": "Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes., [UniProtKB, PubMed, PubMed]; SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]., [RefSeq]; Studies reveal that loss of FAM60A or another component of the Sin3 complex, SDS3, leads to a change in cell morphology and an increase in cell migration, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "Q4KMQ5;Q8N6H0;Q9H8D2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0042826 histone deacetylase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0070822 Sin3-type complex",
        "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 16.9,
        "record_id": "Q9H7L9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P61956-1",
        "uniprot_id": "SUMO2_HUMAN",
        "mass": 10871.0,
        "length": 95,
        "protein_name": "Small ubiquitin-related modifier 2",
        "gene_name": "SUMO2",
        "organism": "Human",
        "refseq_name": "small ubiquitin-related modifier 2 isoform b precursor",
        "refseq_ac": "NP_001005849",
        "gene_names_uniprotkb": "SUMO2; SMT3B; SMT3H2",
        "gene_names_refseq": "HSMT3; SMT3B; SMT3H2; SUMO2",
        "protein_names_uniprotkb": "Small ubiquitin-related modifier 2; HSMT3; SMT3 homolog 2; SUMO-2; SUMO-3; Sentrin-2; Smt3B; Ubiquitin-like protein SMT3B",
        "protein_names_refseq": "SMT3 homolog 2; SMT3 suppressor of mif two 3 homolog 2; sentrin 2; small ubiquitin-related modifier 2 isoform b precursor; ubiquitin-like protein SMT3B",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:6613);  (R-HSA-196791);  (R-HSA-3065676);  (R-HSA-3065678);  (R-HSA-3065679);  (R-HSA-3108214);  (R-HSA-3232118);  (R-HSA-3899300);  (R-HSA-4085377);  (R-HSA-4090294);  (R-HSA-4551638);  (R-HSA-4570464);  (R-HSA-4615885);  (R-HSA-5693607);  (R-HSA-5696395);  (R-HSA-9843940)",
        "pathway_count": 16,
        "publication_count": 411,
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        "class_list": "",
        "function": "Characterizing the Conformational Dynamics of Human SUMO2: Insights into its Interaction with Metal Ions and SIMs., [RefSeq, PubMed]; Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2. Publication Status: Online-Only, [RefSeq, PubMed]; NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation. Erratum:[Cell Death Dis. 2024 Jul 11;15(7):495. doi: 10.1038/s41419-024-06859-4. PMID: 38991998] Publication Status: Online-Only, [RefSeq, PubMed]; SUMO paralogue-specific functions revealed through systematic analysis of human knockout cell lines and gene expression data., [RefSeq, PubMed]; SUMO2/3 promotes the progression and oxaliplatin resistance of colorectal cancer through facilitating the SUMOylation at Ku80-K307., [RefSeq, PubMed]; This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]., [RefSeq]; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "secondary_ac_list": "B2R4I2;P55855;Q32Q42;Q6IPZ6;Q96HK1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0031625 ubiquitin protein ligase binding;GO:0019789 SUMO transferase activity;GO:0044389 ubiquitin-like protein ligase binding;GO:0031386 protein tag activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body",
        "go_biological_process": "GO:0016925 protein sumoylation;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process",
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        "record_id": "P61956-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99471-1",
        "uniprot_id": "PFD5_HUMAN",
        "mass": 17328.0,
        "length": 154,
        "protein_name": "Prefoldin subunit 5",
        "gene_name": "PFDN5",
        "organism": "Human",
        "refseq_name": "prefoldin subunit 5 isoform alpha",
        "refseq_ac": "NP_002615",
        "gene_names_uniprotkb": "PFDN5; MM1; PFD5",
        "gene_names_refseq": "MM-1; MM1; PFD5; PFDN5",
        "protein_names_uniprotkb": "Prefoldin subunit 5; Myc modulator 1; c-Myc-binding protein Mm-1",
        "protein_names_refseq": "c-myc binding protein; myc modulator-1; prefoldin subunit 5 isoform alpha",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5204);  (R-HSA-389957)",
        "pathway_count": 2,
        "publication_count": 102,
        "publication_id_list": "11237011;11567024;16173081;17697703;19608861;22223895;22424782;23186163;23481700;24366607;24715725;25576301;25880248;25892735;26154972;26375851;26768311;26992070;27397612;27600516;27846572;27862975;27920218;28218747;28228285;28510447;28514659;28832583;28834231;28860189;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30192525;30315122;30410026;30429286;30484775;30524438;30779550;31154438;31217245;31222486;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33214551;33298915;33392160;33592498;33691108;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34405274;34509645;34932366;35051231;35154160;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37938771;38216914;39396557;9630229;9792694",
        "class_list": "",
        "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Lysine demethylase 5C inhibits transcription of prefoldin subunit 5 to activate c-Myc signal transduction and colorectal cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; PFDN5 plays a dual role in breast cancer and regulates tumor immune microenvironment: Insights from integrated bioinformatics analysis and experimental validation., [RefSeq, PubMed]; This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9A8;Q54AA8;Q9C083;Q9C084",
        "ec_number_list": "",
        "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0001540 amyloid-beta binding;GO:0003714 transcription corepressor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016272 prefoldin complex;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0050821 protein stabilization;GO:0006457 protein folding",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "Q99471-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92769-1",
        "uniprot_id": "HDAC2_HUMAN",
        "mass": 55364.0,
        "length": 488,
        "protein_name": "Histone deacetylase 2",
        "gene_name": "HDAC2",
        "organism": "Human",
        "refseq_name": "histone deacetylase 2",
        "refseq_ac": "NP_001518",
        "gene_names_uniprotkb": "HDAC2",
        "gene_names_refseq": "HD2; HDAC2; KDAC2; RPD3; YAF1",
        "protein_names_uniprotkb": "Histone deacetylase 2; 3.5.1.-; 3.5.1.98; HD2; Protein deacylase HDAC2",
        "protein_names_refseq": "YY1-associated factor 1; histone deacetylase 2; protein deacylase HDAC2; transcriptional regulator homolog RPD3",
        "tax_id": 9606,
        "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); stroke (Disease Ontology:DOID:0051061); prostate carcinoma (Disease Ontology:DOID:10286); stomach cancer (Disease Ontology:DOID:10534); alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328); bronchitis (Disease Ontology:DOID:6132); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); Peyronie's disease (Disease Ontology:DOID:8616); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:3066);  (R-HSA-193670);  (R-HSA-2122947);  (R-HSA-2644606);  (R-HSA-2894862);  (R-HSA-3214815);  (R-HSA-350054);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-4551638);  (R-HSA-6804758);  (R-HSA-73762);  (R-HSA-8943724);  (R-HSA-9022692);  (R-HSA-9022699);  (R-HSA-9615017);  (R-HSA-9619665);  (R-HSA-9679191);  (R-HSA-9701898);  (R-HSA-9764725);  (R-HSA-983231);  (R-HSA-9843940);  (R-HSA-9844594);  (R-HSA-9845323);  (R-HSA-9937850);  (R-HSA-9940951);  (R-HSA-9976102)",
        "pathway_count": 27,
        "publication_count": 559,
        "publication_id_list": 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        "class_list": "",
        "function": "ACAP3 negatively regulated by HDAC2 inhibits the malignant development of papillary thyroid carcinoma cells., [RefSeq, PubMed]; HDAC2 promotes autophagy-associated HCC malignant progression by transcriptionally activating LAPTM4B. Publication Status: Online-Only, [RefSeq, PubMed]; HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair., [RefSeq, PubMed]; Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:35044827)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MSin3A interacts with HDAC2 via the HDAC-interacting domain (HID) of mSin3A., [RefSeq, PubMed]; The Epigenetic Modifiers HDAC2 and HDAC7 Inversely Associate with Cancer Stemness and Immunity in Solid Tumors. Publication Status: Online-Only, [RefSeq, PubMed]; This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 19,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KRS5;B4DL58;E1P561;Q5SRI8;Q5SZ86;Q8NEH4",
        "ec_number_list": "2.3.2.-;3.5.1.-;3.5.1.98;3.6.4.-;1.14.11.-;1.14.11.65;1.14.99.66;3.1.3.11;2.1.1.37;2.7.1.1;2.7.1.-;4.1.1.32;2.7.11.-;3.1.3.9;2.1.1.367;2.1.1.-;2.1.1.364;2.3.2.27;2.3.1.48;2.3.1.-;2.1.1.356;2.3.1.57;3.5.1.48;3.5.1.62;2.3.1.286;2.1.1.361",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0031072 heat shock protein binding;GO:0042826 histone deacetylase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0035098 ESC/E(Z) complex",
        "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0009913 epidermal cell differentiation;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling",
        "synthesized_glycan_count": 0,
        "hit_score": 56.5,
        "record_id": "Q92769-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P78371-1",
        "uniprot_id": "TCPB_HUMAN",
        "mass": 57488.0,
        "length": 535,
        "protein_name": "T-complex protein 1 subunit beta",
        "gene_name": "CCT2",
        "organism": "Human",
        "refseq_name": "T-complex protein 1 subunit beta isoform 2",
        "refseq_ac": "NP_001185771",
        "gene_names_uniprotkb": "CCT2; 99D8.1; CCTB",
        "gene_names_refseq": "99D8.1; CCT-beta; CCT2; CCTB; HEL-S-100n; PRO1633; TCP-1-beta",
        "protein_names_uniprotkb": "T-complex protein 1 subunit beta; 3.6.1.-; CCT-beta; Chaperonin containing T-complex polypeptide 1 subunit 2; TCP-1-beta",
        "protein_names_refseq": "T-complex protein 1 subunit beta isoform 2; T-complex protein 1 subunit beta; T-complex protein 1, beta subunit; chaperonin containing TCP1, subunit 2 (beta); chaperonin containing t-complex polypeptide 1, beta subunit; chaperonin containing t-complex polypeptide 1, subunit 2; epididymis secretory sperm binding protein Li 100n",
        "tax_id": 9606,
        "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791); candidiasis (Disease Ontology:DOID:1508)",
        "pathway": " (hsa:10576);  (R-HSA-389957);  (R-HSA-389960);  (R-HSA-390450);  (R-HSA-390471);  (R-HSA-5620922);  (R-HSA-6798695);  (R-HSA-6814122);  (R-HSA-9013418);  (R-HSA-9013422)",
        "pathway_count": 10,
        "publication_count": 188,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11252952;12502735;12665801;14532270;14654843;15107402;15258860;15314642;15889144;16408927;16702223;16717095;17074750;17574030;18212344;18369606;18775504;18835386;18991276;19011634;19054851;19081074;19332537;19376773;19421068;19575670;19608861;20068231;20080638;20166139;20233871;20603001;21098288;21136679;21406692;21427764;21440620;21995946;22072986;22139371;22223895;22389062;22424782;22500027;22544926;22645359;23186163;23301498;23351793;23481700;23637185;23650620;23747015;24296415;24366607;24397554;24608665;24714562;24715725;24756126;25342745;25418920;25443296;25446516;25467444;25502872;25576301;25645385;25659125;25675501;25810538;25892735;26154972;26375851;26728094;26992070;27314390;27353360;27452731;27543614;27600516;27846572;27862975;27920218;27941885;28218747;28228285;28514659;28649982;28832583;28834231;28904123;29242379;29314611;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30315122;30410026;30429286;30484775;30524438;30626607;30779550;30833945;30896450;31020640;31092671;31154438;31217245;31222486;31431478;31530632;31844290;31848261;31871319;31937595;31998317;32119511;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33091337;33123756;33141586;33144677;33214551;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34211107;34357683;34405274;34433824;34509645;34725712;34932366;35051231;35083852;35138101;35154160;35251023;35318648;35449234;35561310;35580925;36010968;36215666;36241641;36284347;36493755;37193829;37938771;38165547;38665916;39327245;40914422;8692836;9153422;9819444",
        "class_list": "",
        "function": "CCT2 Regulates ZEB1-Induced EMT Gene Transcription to Promote the Metastasis and Tumorigenesis of Papillary Thyroid Carcinoma., [RefSeq, PubMed]; CCT2 prevented beta-catenin proteasomal degradation to sustain cancer stem cell traits and promote tumor progression in epithelial ovarian cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K402;B5BTY7;B7Z243;B7Z7K4;B7ZAT2;Q14D36;Q6IAT3",
        "ec_number_list": "5.6.2.4;3.6.5.-;3.6.1.-;3.6.4.-;3.6.4.13;4.6.1.19;3.2.1.24;1.2.1.12;3.5.1.-;3.5.1.98;2.7.11.39;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.4.-;3.1.4.35;3.6.5.2;5.2.1.8;1.6.2.2;3.2.1.45;2.4.1.-;3.2.1.-;3.2.1.46;3.2.1.51;3.5.3.1;1.11.2.2;3.1.3.1;3.9.1.1;3.2.1.22;3.4.21.4;3.2.1.52;3.2.1.31;3.4.21.37;3.4.21.20;4.6.1.18;3.4.16.5;3.4.16.-;2.4.1.1;3.1.27.-;4.2.99.18;5.6.1.6;3.1.6.8;3.1.6.14;3.1.6.12;3.2.1.23;5.6.2.3;1.1.1.205;3.5.1.26;3.4.21.76;3.6.4.12;2.7.11.24;1.11.1.27;3.1.1.4;2.3.1.23;3.1.6.4;3.4.21.53;5.6.2.5;2.7.10.2;3.1.-.-;3.4.19.12;2.3.3.8;3.4.14.1;3.2.1.17;7.6.2.1;2.7.11.13;2.3.2.27;2.7.11.1;7.2.2.-;5.6.2.-;2.3.2.-;6.3.4.21;1.8.4.-;5.3.4.1;3.6.1.15;3.4.19.9;3.6.-.-;3.4.24.-;1.6.5.5;3.1.3.16;3.1.13.1;5.6.2.6;3.4.-.-;3.1.13.-;5.3.99.3;2.7.1.91;2.3.1.-;3.5.4.4;3.4.14.2;3.5.3.15;2.7.4.3",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031625 ubiquitin protein ligase binding;GO:0044183 protein folding chaperone",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005874 microtubule;GO:0070062 extracellular exosome;GO:0035578 azurophil granule lumen",
        "go_biological_process": "GO:0090666 scaRNA localization to Cajal body;GO:1904871 positive regulation of protein localization to Cajal body;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization;GO:0006457 protein folding",
        "synthesized_glycan_count": 0,
        "hit_score": 19.3,
        "record_id": "P78371-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BX70-1",
        "uniprot_id": "BTBD2_HUMAN",
        "mass": 55931.0,
        "length": 525,
        "protein_name": "BTB/POZ domain-containing protein 2",
        "gene_name": "BTBD2",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing protein 2",
        "refseq_ac": "NP_060267",
        "gene_names_uniprotkb": "BTBD2",
        "gene_names_refseq": "BTBD2",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein 2",
        "protein_names_refseq": "BTB (POZ) domain containing 2; BTB/POZ domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55643)",
        "pathway_count": 1,
        "publication_count": 64,
        "publication_id_list": "11237011;11818025;12878161;22898188;23481700;24715725;25418920;25576301;25645385;26154972;26375851;26811146;26929215;26992070;27600516;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29786170;30315122;30429286;30524438;30779550;31154438;31217245;31222486;31844290;31848261;32157095;32350084;32357974;32387766;32488085;32897882;32938616;32983136;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34405274;34509645;34932366;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37938771",
        "class_list": "",
        "function": "Subcellular colocalization of BTBD1 and BTBD2 to cytoplasmic bodies; TRIM5delta colocalized with BTBD1/2 and appeared to serve as a scaffold for the assembly of endogenous BTBD1/2 proteins, [RefSeq, PubMed]; The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60418;O75248;Q4VBZ1;Q6IAC5;Q7Z5W0;Q96SX8;Q9NPS1;Q9NX81",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0000932 P-body;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0022008 neurogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q9BX70-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NVH2-1",
        "uniprot_id": "INT7_HUMAN",
        "mass": 106834.0,
        "length": 962,
        "protein_name": "Integrator complex subunit 7",
        "gene_name": "INTS7",
        "organism": "Human",
        "refseq_name": "integrator complex subunit 7 isoform 4",
        "refseq_ac": "NP_001186738",
        "gene_names_uniprotkb": "INTS7; C1orf73",
        "gene_names_refseq": "C1orf73; INT7; INTS7",
        "protein_names_uniprotkb": "Integrator complex subunit 7; Int7",
        "protein_names_refseq": "integrator complex subunit 7 isoform 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25896);  (R-HSA-6807505)",
        "pathway_count": 2,
        "publication_count": 128,
        "publication_id_list": "10.1101/2023.09.13.557529;10022900;11230166;11237011;11856838;12414730;12574128;14701755;1535687;16239144;16308568;16901896;1739980;18079403;1829677;18452278;18691976;19667075;20068231;20457598;2125285;21659603;22137580;22231121;22252320;22441827;23166507;23186163;23481700;23904267;23932780;24097444;24270878;24714562;24715725;24997600;25418920;25576301;25645385;25675981;25880248;26375851;26728094;26811146;26992070;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;2944599;29471365;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30379171;30410026;30429286;30524438;30779550;30833945;31217245;31844290;31848261;31998317;32157095;32161166;32265295;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33243860;33298915;33592498;33633747;33691108;33717175;33912179;33936100;33968037;34171305;34211107;34357683;34405274;34509645;34561969;34762484;34932366;35051231;35154160;35580925;36010968;36241641;36284347;36869814;37938771;38570683;38665916;39032490;39531497;40914422;7715707;8253082;8339931;8628262;8668525;9009278;9153304;9188510;9407024;9705341;9832505",
        "class_list": "",
        "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). Plays a role in DNA damage response (DDR) signaling during the S phase (PubMed:21659603)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DLZ6;B7WNP6;B7WPB6;Q8N4K7;Q8WUH5;Q9H9V3;Q9NVU5;Q9UFC6;Q9UFM3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0005694 chromosome",
        "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0071479 cellular response to ionizing radiation;GO:0000077 DNA damage checkpoint signaling;GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing",
        "synthesized_glycan_count": 0,
        "hit_score": 13.8,
        "record_id": "Q9NVH2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NZP8-1",
        "uniprot_id": "C1RL_HUMAN",
        "mass": 53498.0,
        "length": 487,
        "protein_name": "Complement C1r subcomponent-like protein",
        "gene_name": "C1RL",
        "organism": "Human",
        "refseq_name": "complement C1r subcomponent-like protein isoform 2 precursor",
        "refseq_ac": "NP_001284569",
        "gene_names_uniprotkb": "C1RL; C1RL1; C1RLP; CLSPA",
        "gene_names_refseq": "C1RL1; C1RLP; C1RL; C1r-LP; CLSPa",
        "protein_names_uniprotkb": "Complement C1r subcomponent-like protein; 3.4.21.-; C1r-LP; C1r-like protein; C1r-like serine protease analog protein; CLSPa",
        "protein_names_refseq": "C1r-like serine protease analog protein; complement C1r subcomponent-like protein isoform 2 precursor; complement C1r subcomponent-like protein; complement C1r-like proteinase; complement component 1, r subcomponent-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51279)",
        "pathway_count": 1,
        "publication_count": 35,
        "publication_id_list": "10.1021/acs.analchem.6b02887;10.1101/2023.09.13.557529;11237011;15358180;15385675;15527420;16335952;19139490;19159218;19344414;19423540;20406964;20438785;23090970;24190977;28035807;29391424;29557506;29671580;29741879;30237853;30459171;30484775;31844290;32125861;32350084;32938616;32993564;33091337;33298915;35154160;35251023;36215666;37074911;39894887",
        "class_list": "",
        "function": "CLSPa itself possesses little protease activity, but it plays an inhibitory role in other active protease catalytic processes, [RefSeq, PubMed]; Coexpression of the proform of Hp (proHp) and C1r-LP effected cleavage of proHp in the endoplasmic reticulum, [RefSeq, PubMed]; Immunological and clinicopathological characteristics of C1RL in 2120 glioma patients. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 35,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53GX9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0070062 extracellular exosome;GO:0072562 blood microparticle",
        "go_biological_process": "GO:0045087 innate immune response;GO:0031638 zymogen activation;GO:0006958 complement activation, classical pathway;GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q9NZP8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UIS9-1",
        "uniprot_id": "MBD1_HUMAN",
        "mass": 66607.0,
        "length": 605,
        "protein_name": "Methyl-CpG-binding domain protein 1",
        "gene_name": "MBD1",
        "organism": "Human",
        "refseq_name": "methyl-CpG-binding domain protein 1 isoform 6",
        "refseq_ac": "NP_001191065",
        "gene_names_uniprotkb": "MBD1; CXXC3; PCM1",
        "gene_names_refseq": "CXXC3; MBD1; PCM1; RFT",
        "protein_names_uniprotkb": "Methyl-CpG-binding domain protein 1; CXXC-type zinc finger protein 3; Methyl-CpG-binding protein MBD1; Protein containing methyl-CpG-binding domain 1",
        "protein_names_refseq": "CXXC-type zinc finger protein 3; methyl-CpG-binding domain protein 1 isoform 6; protein containing MBD 1; protein containing methyl-CpG-binding domain 1; the regulator of fibroblast growth factor 2 (FGF-2) transcription",
        "tax_id": 9606,
        "disease": "lung cancer (Disease Ontology:DOID:1324); transient cerebral ischemia (Disease Ontology:DOID:224)",
        "pathway": " (hsa:4152);  (R-HSA-3899300)",
        "pathway_count": 2,
        "publication_count": 89,
        "publication_id_list": "10441743;10454587;10581239;10648624;11237011;11371345;11477070;11842083;12150977;12529333;12665582;12679040;12697822;12711603;12718889;14555760;14610093;14728690;15327775;15691849;15766567;15958389;15976810;16098147;16757475;17066076;17079232;17081983;17081986;17298944;17369852;17525332;17535915;17803295;17942393;18077418;18082607;18211901;18339323;18488044;18669648;19240082;19596686;19615980;19666599;19690332;19995069;20068231;20098713;20176810;20676127;21338522;21527249;22467880;22713328;23186163;23404503;23481700;23673342;24275569;24715725;25114211;25218447;25755297;25772364;25800734;26354109;26992070;28449087;28473981;29276034;29493099;30315122;30429286;30487699;30784271;30849389;31154438;31612521;31844290;32488085;33141586;33298915;33968037;34019948;34087483;35051231;9207790;9774669",
        "class_list": "",
        "function": "MBD1 may be a tumor suppressor gene in advanced colorectal cancer (CRC)and affect the development and metastasis of CRC by regulating 8 tumor suppressor genes through binding with SP1., [RefSeq, PubMed]; MBD1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner., [RefSeq, PubMed]; The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]., [RefSeq]; Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; ZEB1 silenced SIRT3 expression via interaction with MBD1 to promote aerobic glycolysis in pancreatic cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 15,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4UTZ0;B4DXJ5;E9PEC5;K7ELI2;K7EQZ4;K7ESN0;O15248;O95241;Q7Z7B5;Q8N4W4;Q9UNZ6;Q9UNZ7;Q9UNZ8;Q9UNZ9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0008327 methyl-CpG binding;GO:0045322 unmethylated CpG binding;GO:0010385 double-stranded methylated DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0016363 nuclear matrix;GO:0005694 chromosome",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II;GO:0006346 DNA methylation-dependent constitutive heterochromatin formation;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 9.2,
        "record_id": "Q9UIS9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WYA1-1",
        "uniprot_id": "BMAL2_HUMAN",
        "mass": 70887.0,
        "length": 636,
        "protein_name": "Basic helix-loop-helix ARNT-like protein 2",
        "gene_name": "BMAL2",
        "organism": "Human",
        "refseq_name": "basic helix-loop-helix ARNT-like protein 2 isoform 2",
        "refseq_ac": "NP_001234931",
        "gene_names_uniprotkb": "BMAL2; ARNTL2; BHLHE6; CLIF; MOP9; PASD9",
        "gene_names_refseq": "ARNTL2; BMAL2; CLIF; MOP9; PASD9; bHLHe6",
        "protein_names_uniprotkb": "Basic helix-loop-helix ARNT-like protein 2; Aryl hydrocarbon receptor nuclear translocator-like protein 2; Basic-helix-loop-helix-PAS protein MOP9; Brain and muscle ARNT-like 2; CLIF; CYCLE-like factor; Class E basic helix-loop-helix protein 6; Member of PAS protein 9; PAS domain-containing protein 9; bHLHe6",
        "protein_names_refseq": "CYCLE-like factor; PAS domain-containing protein 9; aryl hydrocarbon receptor nuclear translocator like 2; basic helix-loop-helix ARNT-like protein 2 isoform 2; basic helix-loop-helix ARNT-like protein 2; basic-helix-loop-helix-PAS protein MOP9; brain and muscle ARNT-like 2; class E basic helix-loop-helix protein 6; member of PAS protein 9; member of PAS superfamily 9; transcription factor BMAL2",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hypertension (Disease Ontology:DOID:10763); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:56938);  (R-HSA-1368108)",
        "pathway_count": 2,
        "publication_count": 41,
        "publication_id_list": "10864977;10964693;11018023;11162494;11237011;11241162;11554928;12055078;12130638;12406875;12738229;14672706;15500444;15560782;16857194;18587630;19710929;20934997;23481700;24715725;28832583;29242379;29508533;29786170;2991279;31844290;31998317;32357974;32938616;32983136;33141586;33968037;34211107;34405274;35051231;38660843;38938563;38956029;39147318;7981125;8618898",
        "class_list": "",
        "function": "ARNTL2 facilitates bladder cancer progression through potentiating ENO1-mediated glycolysis in a SLC31A1-independent and -dependent manner., [RefSeq, PubMed]; Alternative splicing yields novel BMAL2 variants: tissue distribution and functional characterization., [RefSeq, PubMed]; BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance. Publication Status: Online-Only, [RefSeq, PubMed]; The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]., [RefSeq]; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1., [UniProtKB, PubMed, PubMed, PubMed]; [Effects of BMAL2 on Aerobic Glycolysis and Cell Proliferation in Acute Myeloid Leukemia Cells]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z429;F5H402;Q8WYA2;Q8WYA3;Q8WYA4;Q96J63;Q9H2M4;Q9NS70;Q9NYQ4;Q9NYQ5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding",
        "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q8WYA1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P02746-1",
        "uniprot_id": "C1QB_HUMAN",
        "mass": 26722.0,
        "length": 253,
        "protein_name": "Complement C1q subcomponent subunit B",
        "gene_name": "C1QB",
        "organism": "Human",
        "refseq_name": "complement C1q subcomponent subunit B isoform 1 precursor",
        "refseq_ac": "NP_000482",
        "gene_names_uniprotkb": "C1QB",
        "gene_names_refseq": "C1QB; C1QD2",
        "protein_names_uniprotkb": "Complement C1q subcomponent subunit B",
        "protein_names_refseq": "complement C1q chain B; complement C1q subcomponent subunit B isoform 1 precursor; complement C1q subcomponent subunit B; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide; complement component C1q, B chain; complement subcomponent C1q chain B",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); severe acute respiratory syndrome (Disease Ontology:DOID:2945); ocular hypertension (Disease Ontology:DOID:9282); C1Q deficiency 2 (MONDO:MONDO:0958187)",
        "pathway": " (hsa:713);  (R-HSA-166663);  (R-HSA-173623);  (R-HSA-977606)",
        "pathway_count": 4,
        "publication_count": 108,
        "publication_id_list": "10531307;1067618;10925294;11237011;11694537;11939578;12055245;12396008;1249422;12847249;12960167;1386357;14280442;15199963;16079145;16192651;16959974;16999828;17182573;17505110;18250442;19006321;19706439;20548024;21081667;21788512;22802338;23487775;23650384;23783831;2420889;24626930;2465906;2466593;24715725;2481448;26992070;27452731;27726376;27862975;293688;293746;29449492;29557506;2956252;29632711;2971659;29786170;2988513;3000358;301546;30429286;31154438;31848261;32157095;3258649;32983136;33043033;34155115;34932275;35051231;35087514;35459695;35580925;36284347;36443341;37250717;37938771;3848661;4098172;486087;6019133;6208566;6214588;6218163;6219696;6222381;6230668;6238120;6249812;6286235;6334079;6454142;6607952;670886;6776418;6906228;6952210;6981411;702059;70787;708376;7391570;7391573;7542572;760802;761607;7690834;7691959;814163;8345200;8495193;8538770;8786315;9038722;9476130;9777412;978134",
        "class_list": "",
        "function": "Activation of complement C1q and C3 in glomeruli might accelerate the progression of diabetic nephropathy: Evidence from transcriptomic data and renal histopathology., [RefSeq, PubMed]; C1QA, C1QB, and GZMB are novel prognostic biomarkers of skin cutaneous melanoma relating tumor microenvironment. Erratum:[Sci Rep. 2023 Jul 6;13(1):10973. doi: 10.1038/s41598-023-37876-6. PMID: 37414837] Publication Status: Online-Only, [RefSeq, PubMed]; Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:12847249, PubMed:19006321, PubMed:24626930, PubMed:29449492, PubMed:3258649, PubMed:34155115, PubMed:6249812, PubMed:6776418). The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain (PubMed:12847249, PubMed:19006321, PubMed:24626930, PubMed:29449492, PubMed:3258649, PubMed:6776418). Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system (PubMed:29449492). The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM (PubMed:19706439, PubMed:24626930, PubMed:29449492). The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system (PubMed:18250442)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic candidate genes for diabetic nephropathy using bioinformatics analysis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes the B-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. [provided by RefSeq, Dec 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T959;Q96H17",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001786 phosphatidylserine binding;GO:0001791 IgM binding;GO:0019864 IgG binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0045202 synapse;GO:0072562 blood microparticle",
        "go_biological_process": "GO:0045087 innate immune response;GO:0098883 synapse pruning;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.9,
        "record_id": "P02746-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75052-1",
        "uniprot_id": "CAPON_HUMAN",
        "mass": 56150.0,
        "length": 506,
        "protein_name": "Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein",
        "gene_name": "NOS1AP",
        "organism": "Human",
        "refseq_name": "carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 2",
        "refseq_ac": "NP_001119532",
        "gene_names_uniprotkb": "NOS1AP; CAPON; KIAA0464",
        "gene_names_refseq": "6330408P19Rik; CAPON; NOS1AP; NPHS22",
        "protein_names_uniprotkb": "Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; Nitric oxide synthase 1 adaptor protein",
        "protein_names_refseq": "C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON); C-terminal PDZ ligand of neuronal nitric oxide synthase protein; carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 2; carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain; nitric oxide synthase 1 (neuronal) adaptor protein",
        "tax_id": 9606,
        "disease": "nephrotic syndrome type 22 (Disease Ontology:DOID:0112268); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); depressive disorder (Disease Ontology:DOID:1596); congestive heart failure (Disease Ontology:DOID:6000)",
        "pathway": " (hsa:9722)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;16146415;16648850;18220336;18669648;18691976;20068231;23186163;26197318;29242379;29508533;29557506;30779550;31844290;32161166;32938616;33523862;33968037;33981976;34509645;35051231;35353321;35732169;36284347;36463909;9459447",
        "class_list": "",
        "function": "Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Evaluating Common NOS1AP Variants in Patients with Implantable Cardioverter Defibrillators for Secondary Prevention : Evaluating SNPs in NOS1AP., [RefSeq, PubMed]; Influence of NOS1AP Risk Variants on the Corrected QT (QTc) Interval in the Pharmacotherapy of Schizophrenia., [RefSeq, PubMed]; Study adds support to a role of CAPON in schizophrenia, produces new evidence implicating this gene in the etiology of bipolar disorder, and suggests a possible mechanism of action of CAPON in psychiatric illness, [RefSeq, PubMed]; The influence of NOS1AP gene polymorphisms and childhood abuse on antisocial personality disorder in Chinese male violent inmates., [RefSeq, PubMed]; This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZLF5;O43564;Q3T551;Q5VU95",
        "ec_number_list": "",
        "go_molecular_function": "GO:0050998 nitric-oxide synthase binding;GO:0035591 signaling adaptor activity;GO:0030235 nitric-oxide synthase regulator activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0098974 postsynaptic actin cytoskeleton organization;GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization;GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:1901381 positive regulation of potassium ion transmembrane transport;GO:0006809 nitric oxide biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "O75052-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BX63-1",
        "uniprot_id": "FANCJ_HUMAN",
        "mass": 140867.0,
        "length": 1249,
        "protein_name": "Fanconi anemia group J protein",
        "gene_name": "BRIP1",
        "organism": "Human",
        "refseq_name": "Fanconi anemia group J protein",
        "refseq_ac": "NP_114432",
        "gene_names_uniprotkb": "BRIP1; BACH1; FANCJ",
        "gene_names_refseq": "BACH1; BRIP1; FANCJ; OF",
        "protein_names_uniprotkb": "Fanconi anemia group J protein; 5.6.2.3; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; DNA 5'-3' helicase FANCJ",
        "protein_names_refseq": "ATP-dependent RNA helicase BRIP1; BRCA1 interacting helicase 1; BRCA1 interacting protein C-terminal helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1/BRCA2-associated helicase 1; DNA 5'-3' helicase FANCJ; FANCJ helicase; Fanconi anemia group J protein",
        "tax_id": 9606,
        "disease": "Fanconi anemia complementation group J (Disease Ontology:DOID:0111097); Alzheimer's disease (Disease Ontology:DOID:10652); Fanconi anemia (Disease Ontology:DOID:13636); Down syndrome (Disease Ontology:DOID:14250); thrombocytopenia (Disease Ontology:DOID:1588); breast cancer (Disease Ontology:DOID:1612); breast carcinoma (Disease Ontology:DOID:3459); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:83990);  (R-HSA-2564830);  (R-HSA-5685938);  (R-HSA-5685942);  (R-HSA-5693537);  (R-HSA-5693554);  (R-HSA-5693568);  (R-HSA-5693579);  (R-HSA-5693607);  (R-HSA-5693616);  (R-HSA-6804756);  (R-HSA-69473);  (R-HSA-9701192);  (R-HSA-9704331);  (R-HSA-9704646);  (R-HSA-9709570);  (R-HSA-9709603)",
        "pathway_count": 17,
        "publication_count": 256,
        "publication_id_list": "10212258;10373512;10435622;10438626;10500146;10551859;10570149;10570174;10604467;10673500;10673501;10710310;10733923;10744977;10801132;10856253;10859164;10884347;10921897;11006276;11080452;11139606;11237011;11239457;11301010;11376695;11390642;11447225;11459987;11511362;11546806;11551930;11571269;11698410;11740489;11751635;11780126;11832208;11920628;12064478;12139939;12152085;12191481;12226092;12228710;12370410;12379650;12393879;12545175;12565990;12578958;12686547;12702766;12721304;12750383;12791985;12851404;12872252;12912992;12914926;14527420;14576433;14702041;14716019;14734547;14983014;15053879;15125843;15189136;15190204;15359272;15485900;15665856;15703751;15707391;15866171;15916957;16116421;16116423;16116424;16148040;16153896;16322561;16327781;16337601;16360315;16530042;16793542;16885023;16973432;17108107;17114795;17200668;17200671;17200672;17289582;17349958;17420451;17515903;17575048;17591690;17596542;17928296;17962301;17965729;17996710;17996711;18171670;18317453;18426915;18490454;18539610;18541667;18573874;18625724;18669648;18757400;18805091;18923075;18957201;18971343;18987736;19074197;19121998;19268590;19357644;19369211;19419957;19584259;19596236;19609323;19690332;19941829;19965871;20068231;20154705;20207730;20233725;20639400;20729832;20729858;20729859;20802492;20871615;20871616;20959462;20965415;21052091;21240188;21263215;21317932;21325134;21335604;21520333;21565612;21659603;21680713;21777809;21804533;22021381;22024395;22194698;22231403;22593209;22635276;22645308;22661229;22661230;22678361;22678362;22792074;22977173;23000554;23149936;23150669;23186163;23345434;23468639;23485397;23509288;23585563;23676219;23686288;23731732;23754376;23810717;24013206;24076221;24141787;24145406;24167712;24371268;24485656;24509834;24831703;24874608;25113031;25122754;25558984;25659039;26145171;27899578;28089683;28158555;28240985;28319063;29165669;29608566;30289697;30311374;30315122;30379171;31586400;31636395;31757951;31848261;31937595;31998317;32157095;32357974;32387766;32502341;32732220;32897882;32938616;32983136;33141586;33195396;33298915;33691108;33717175;33907233;33912179;33936100;33968037;33978741;34087483;34105348;34171305;34440403;34509645;35051231;35561310;35580925;36010968;36172813;36241641;36581221;36608669;37062450;37561379;38521768;8702565;9705271;9837724;9925639",
        "class_list": "",
        "function": "Association of BARD1 and BRIP1 Gene Polymorphisms with the Risk of Uveal Melanoma., [RefSeq, PubMed]; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells. Publication Status: Online-Only, [RefSeq, PubMed]; Rare variants in FANCJ induce premature ovarian insufficiency in humans and mice., [RefSeq, PubMed]; The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 15,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 9,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A024QZ45;Q3MJE2;Q8NCI5",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;2.7.11.1;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;6.5.1.1;3.6.4.12;3.1.11.-;3.4.21.53;2.3.2.27;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;5.6.2.1;7.2.2.-;5.6.2.-;2.3.2.-;3.6.1.15;3.1.4.-;3.6.-.-;2.3.1.48;2.3.1.-;3.1.22.-;3.4.24.-;3.1.11.2;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016887 ATP hydrolysis activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0005657 replication fork",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006302 double-strand break repair;GO:0000077 DNA damage checkpoint signaling;GO:1990918 double-strand break repair involved in meiotic recombination",
        "synthesized_glycan_count": 0,
        "hit_score": 25.9,
        "record_id": "Q9BX63-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T0F9-1",
        "uniprot_id": "C2D1B_HUMAN",
        "mass": 94224.0,
        "length": 858,
        "protein_name": "Coiled-coil and C2 domain-containing protein 1B",
        "gene_name": "CC2D1B",
        "organism": "Human",
        "refseq_name": "coiled-coil and C2 domain-containing protein 1B isoform 2",
        "refseq_ac": "NP_001317514",
        "gene_names_uniprotkb": "CC2D1B; KIAA1836; LGD1",
        "gene_names_refseq": "CC2D1B; Lgd1",
        "protein_names_uniprotkb": "Coiled-coil and C2 domain-containing protein 1B; FRE under dual repression-binding protein 2; Five prime repressor element under dual repression-binding protein 2; Freud-2",
        "protein_names_refseq": "FRE under dual repression-binding protein 2; coiled-coil and C2 domain-containing protein 1B isoform 2; coiled-coil and C2 domain-containing protein 1B; five prime repressor element under dual repression-binding protein 2; freud-2; lethal (2) giant discs homolog 1",
        "tax_id": 9606,
        "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)",
        "pathway": " (hsa:200014);  (R-HSA-9668328)",
        "pathway_count": 2,
        "publication_count": 25,
        "publication_id_list": "11237011;17084358;19423080;23186163;26040712;26040713;27769858;28242692;28832583;28904123;29557506;29789417;30379171;30513301;32157095;32350084;32938616;32983136;33034024;33349255;33691108;33968037;34087483;35051231;39531497",
        "class_list": "",
        "function": "CC2D1B is essential for ESCRT-III activity during mitotic reformation of the nuclear envelope., [RefSeq, PubMed]; CC2D1B regulates degradation and signaling of EGFR and TLR4., [RefSeq, PubMed]; Human Freud-2/CC2D1B binds to the 5-HT1A dual repressor element and represses the human 5-HT1A receptor gene to regulate its expression in non-serotonergic cells and neurons., [RefSeq, PubMed]; Paper describes a function of Cc2d1b/Cc2d1a and their Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking., [RefSeq, PubMed]; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Unravelling of Hidden Secrets: The Tumour Suppressor Lethal (2) Giant Discs (Lgd)/CC2D1, Notch Signalling and Cancer. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q49AE8;Q5T0F8;Q5T0G0;Q6ZNQ1;Q96AP3;Q96I04;Q96JJ1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q5T0F9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UMX2-1",
        "uniprot_id": "OAZ3_HUMAN",
        "mass": 27413.0,
        "length": 235,
        "protein_name": "Ornithine decarboxylase antizyme 3",
        "gene_name": "OAZ3",
        "organism": "Human",
        "refseq_name": "ornithine decarboxylase antizyme 3 isoform 1",
        "refseq_ac": "NP_057262",
        "gene_names_uniprotkb": "OAZ3",
        "gene_names_refseq": "AZ3; OAZ-t; OAZ3; TISP15",
        "protein_names_uniprotkb": "Ornithine decarboxylase antizyme 3; AZ3; ODC-Az 3",
        "protein_names_refseq": "ODC-Az 3; antizyme 3; ornithine decarboxylase antizyme 3 isoform 1; testicular secretory protein Li 31",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51686);  (R-HSA-350562);  (R-HSA-351202)",
        "pathway_count": 3,
        "publication_count": 16,
        "publication_id_list": "10623504;10781085;11237011;11583147;12359729;12660156;15749015;16542438;17407445;17585781;17900240;18367445;2069720;26443277;7546290;7811704",
        "class_list": "",
        "function": "Antizyme expression requires programmed, ribosomal frameshifting, [RefSeq, PubMed]; Mutations in the OAZ3 gene are not a common cause of male infertility. GeneRIF: Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Dec 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E7EUE7;Q6GMR0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008073 ornithine decarboxylase inhibitor activity;GO:0071532 ankyrin repeat binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0072562 blood microparticle",
        "go_biological_process": "GO:1902268 negative regulation of polyamine transmembrane transport;GO:0007283 spermatogenesis;GO:0090316 positive regulation of intracellular protein transport;GO:0045732 positive regulation of protein catabolic process;GO:0051497 negative regulation of stress fiber assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q9UMX2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TDN4-1",
        "uniprot_id": "CABL1_HUMAN",
        "mass": 67599.0,
        "length": 633,
        "protein_name": "CDK5 and ABL1 enzyme substrate 1",
        "gene_name": "CABLES1",
        "organism": "Human",
        "refseq_name": "CDK5 and ABL1 enzyme substrate 1 isoform 2",
        "refseq_ac": "NP_001094089",
        "gene_names_uniprotkb": "CABLES1; CABLES",
        "gene_names_refseq": "CABL1; CABLES1; CABLES; HsT2563; IK3-1",
        "protein_names_uniprotkb": "CDK5 and ABL1 enzyme substrate 1; Ik3-1; Interactor with CDK3 1",
        "protein_names_refseq": "CDK5 and ABL1 enzyme substrate 1 isoform 2; CDK5 and ABL1 enzyme substrate 1; interactor with CDK3 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91768);  (R-HSA-69202);  (R-HSA-69656);  (R-HSA-983231)",
        "pathway_count": 4,
        "publication_count": 93,
        "publication_id_list": "10.1101/2023.09.13.557529;10323868;10375532;10454565;11042108;11062261;11231585;11237011;11242053;11585773;11706030;11733001;11744692;11751636;11895428;11907280;11950885;12032298;12134158;12427746;12730199;1312467;1396589;14729625;15020713;15247287;15710388;16054028;16177568;1630448;16582612;17027967;17196961;18220336;18691976;19293402;19369195;20530532;20627800;218813;23186163;25502872;25576301;25645385;26154972;26845023;27600516;27846572;27920218;28228285;28514659;28583208;28832583;29242379;29393594;29557506;29632046;30484775;30833945;31092671;31154438;31530632;31844290;31848261;32157095;32161166;32350084;32488085;32502341;33936100;3409321;34171305;34932366;35051231;36241641;36284347;37074911;37555665;7629134;7743995;7799941;8662638;8700224;8816476;9065479;9230307;9326583;9331217;9422515;9482921;9632134;9891042;9927674",
        "class_list": "",
        "function": "Analysis of the RT-PCR prducts of the CABLES1 gene showed eight intragenic deletions in its mRNA transcripts; 5/8 are the result of RNA splicing., [RefSeq, PubMed]; CABLES1 expression is reduced in human subcutaneous adipose tissue in obesity and type 2 diabetes but may not directly impact adipocyte glucose and lipid metabolism., [RefSeq, PubMed]; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity)., [UniProtKB]; MiR199a-3p and P53 are coupled through CABLES1 and comprise a novel negative feedback loop that likely contributes to cardiac c-kit(+) cell proliferation and apoptosis. Erratum:[Stem Cell Res Ther. 2019 Dec 20;10(1):404. doi: 10.1186/s13287-019-1514-4. PMID: 31862017] Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 9507,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DK60;Q8N3Y8;Q8NA22;Q9BTG1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol",
        "go_biological_process": "GO:0007399 nervous system development;GO:0051301 cell division;GO:0051726 regulation of cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "Q8TDN4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P17213-1",
        "uniprot_id": "BPI_HUMAN",
        "mass": 53900.0,
        "length": 487,
        "protein_name": "Bactericidal permeability-increasing protein",
        "gene_name": "BPI",
        "organism": "Human",
        "refseq_name": "bactericidal permeability-increasing protein precursor",
        "refseq_ac": "NP_001716",
        "gene_names_uniprotkb": "BPI",
        "gene_names_refseq": "BPIFD1; BPI; rBPI",
        "protein_names_uniprotkb": "Bactericidal permeability-increasing protein; BPI; CAP 57",
        "protein_names_refseq": "BPI fold containing family D, member 1; CAP 57; bactericidal permeability-increasing protein precursor; recombinant BPI holoprotein, rBPI",
        "tax_id": 9606,
        "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945); Crohn's disease (Disease Ontology:DOID:8778)",
        "pathway": " (hsa:671);  (R-HSA-166016);  (R-HSA-6798695);  (R-HSA-6803157)",
        "pathway_count": 4,
        "publication_count": 105,
        "publication_id_list": "10201950;10843855;11120840;11237011;11274165;11313366;11389039;11971875;12471095;12493837;13816;14506276;14556004;14739326;1522221;15229136;15276183;15596121;15778384;15826377;15956276;16054449;16215847;16303959;16336202;16354652;16354654;16374474;16467847;16751103;16757566;16799473;16931762;16940129;17363965;17502600;17567961;17678885;17964057;18021746;18160480;18185531;18222170;18233961;18297073;18673279;19095652;19179970;19254208;1937776;19818633;20103720;20180804;20382864;20395631;20510021;20845358;21787330;22078883;22158869;22262861;22327069;22455996;22701042;23302724;23426625;23650620;24219363;24256734;2462607;2477488;2501794;25075772;25461571;25596890;25825441;26148048;26992070;27089320;2722846;28228285;29557506;29789417;30315122;30429286;30581431;31106488;32705592;3286634;32983136;34171305;34815797;35051231;3537192;36284347;36672756;3667613;7517398;8692836;8812832;9188532;9523110;9665269;9665271;9756476",
        "class_list": "",
        "function": "BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus. Publication Status: Online-Only, [RefSeq, PubMed]; Define BPI as an immune enhancing pattern recognition molecule in Gram-positive infections. Publication Status: Online-Only, [RefSeq, PubMed]; Lipopolysaccharide-Binding Protein and Bactericidal/Permeability-Increasing Protein in Lipid Metabolism and Cardiovascular Diseases. Review article, [RefSeq, PubMed]; Molecular Evolution of the Bactericidal/Permeability-Increasing Protein (BPIFA1) Regulating the Innate Immune Responses in Mammals. Publication Status: Online-Only, [RefSeq, PubMed]; Serum BPI protein levels are associated with inflammatory status in chronic obstructive pulmonary disease patients with pulmonary Pseudomonas aeruginosa colonization., [RefSeq, PubMed]; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]., [RefSeq]; This review article focuses on the structural and functional properties of BPI with respect to its antimicrobial contribution to host defense during GNB infections and endotoxin-induced inflammation. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCY2;Q1ZZU8;Q5JRW0;Q8IW58;Q9BYZ9;Q9H1L2;Q9H1M8;Q9H203;Q9UCT4;Q9UD65",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0070062 extracellular exosome;GO:0035578 azurophil granule lumen;GO:0035580 specific granule lumen",
        "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0032715 negative regulation of interleukin-6 production;GO:0032720 negative regulation of tumor necrosis factor production;GO:0043031 negative regulation of macrophage activation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.6,
        "record_id": "P17213-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y2H0-2",
        "uniprot_id": "DLGP4_HUMAN",
        "mass": 108012.0,
        "length": 992,
        "protein_name": "Disks large-associated protein 4",
        "gene_name": "DLGAP4",
        "organism": "Human",
        "refseq_name": "disks large-associated protein 4 isoform c",
        "refseq_ac": "NP_001035951",
        "gene_names_uniprotkb": "DLGAP4; DAP4; KIAA0964; SAPAP4",
        "gene_names_refseq": "DAP-4; DAP4; DLGAP4; DLP4; SAPAP-4; SAPAP4",
        "protein_names_uniprotkb": "Disks large-associated protein 4; DAP-4; PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4; SAPAP-4",
        "protein_names_refseq": "PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4; discs large homolog associated protein 4; disks large-associated protein 4 isoform c; disks large-associated protein 4",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)",
        "pathway": " (hsa:22839);  (R-HSA-6794361)",
        "pathway_count": 2,
        "publication_count": 67,
        "publication_id_list": "10.1101/2023.09.13.557529;10521485;11604393;15540461;16242404;16624946;16846852;17897391;18669648;18812509;18829961;20064387;20064388;20068231;20519524;21282647;21406692;23186163;23481700;24715725;25378172;25576301;26154972;26375851;26992070;27846572;28411811;28657654;29557506;30410026;31844290;31937595;32157095;32350084;32488085;32502341;32938616;32983136;33141586;33298915;33392160;33592498;33936100;33968037;34078123;34171305;34185709;34211107;34357683;34405274;35051231;35580925;36010968;36215666;36396671;36581221;37217939;37615249;37822284;37938771;7695896;7736595;8576240;9069287;9115257;9808458;9927700",
        "class_list": "",
        "function": "CircDLGAP4 induces autophagy and improves endothelial cell dysfunction in atherosclerosis by targeting PTPN4 with miR-134-5p., [RefSeq, PubMed]; CircDLGAP4 overexpression ameliorates neuronal injury in Parkinson's disease by binding to EIF4A3 and increasing HMGA2 expression., [RefSeq, PubMed]; DLGAP4 acts as an effective prognostic predictor for hepatocellular carcinoma and is closely related to tumour progression. Publication Status: Online-Only, [RefSeq, PubMed]; Includes the identification and characterization of an homologous protein in rat., [RefSeq, PubMed]; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane., [UniProtKB]; Shows that an homologous rat protein can interact with nArgBP2, a novel neural member of the ponsin/ArgB/vinexin family., [RefSeq, PubMed]; The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P5T5;Q5QPG4;Q5T2Y4;Q5T2Y5;Q9H137;Q9H138;Q9H1L7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0060090 molecular adaptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0031594 neuromuscular junction;GO:0098981 cholinergic synapse;GO:0099572 postsynaptic specialization",
        "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0023052 signaling;GO:0090128 regulation of synapse maturation;GO:0099010 modification of postsynaptic structure",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q9Y2H0-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60885-1",
        "uniprot_id": "BRD4_HUMAN",
        "mass": 152219.0,
        "length": 1362,
        "protein_name": "Bromodomain-containing protein 4",
        "gene_name": "BRD4",
        "organism": "Human",
        "refseq_name": "bromodomain-containing protein 4 isoform 3",
        "refseq_ac": "NP_001317313",
        "gene_names_uniprotkb": "BRD4; HUNK1",
        "gene_names_refseq": "BRD4; CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP",
        "protein_names_uniprotkb": "Bromodomain-containing protein 4; Protein HUNK1",
        "protein_names_refseq": "bromodomain-containing protein 4 isoform 3; bromodomain-containing protein 4; chromosome-associated protein; female sterile homeotic related gene 4; mitotic chromosome-associated protein",
        "tax_id": 9606,
        "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Cornelia de Lange syndrome 6 (Disease Ontology:DOID:0060970); nephrocalcinosis (Disease Ontology:DOID:12679); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); papillary thyroid carcinoma (Disease Ontology:DOID:3969)",
        "pathway": " (hsa:23476);  (R-HSA-9679191);  (R-HSA-9909649)",
        "pathway_count": 3,
        "publication_count": 167,
        "publication_id_list": "10087012;11237011;11733348;12192049;12543779;15302935;16109376;16109377;16115318;16522641;16940503;17081983;17189189;17287340;17322306;17344846;17662961;17924679;18212344;18452278;18491316;18500820;18669648;18767875;18922874;18991276;19088198;19103749;19413330;19596240;19608861;19651622;19664995;20068230;20068231;20223979;20871596;21068722;21406692;21555454;21568322;21890894;21964340;22136404;22137933;22334664;22401777;22464331;22509028;22552008;22645123;22814904;23027873;23086925;23095041;23186163;23317504;23517011;23530754;23589332;23641311;23728299;24272870;24275569;24360279;24466310;24584101;25114211;25218447;25367160;25576301;25593309;25645385;25755297;25772364;25801024;25810538;26002965;26811146;26853435;26992070;27846572;27862975;27920218;28218747;28228285;28425720;28481868;28733670;28832583;28904123;29176719;29242379;29351928;29374058;29379197;29393594;29557506;29945920;30059200;30201761;30315122;30379171;30385408;30429286;30620550;30779550;30833945;31048504;31092671;31154438;31217245;31292434;31530632;31832310;31844290;31848261;31969702;32157095;32161166;32183950;32193360;32265295;32350084;32357974;32387766;32488085;32502341;32574038;32575711;32860047;32938616;32983136;33214551;33298915;33537174;33592498;33691108;33717175;33836029;33912179;33968037;34019948;34171305;34229054;34290255;34846842;35051231;35254053;35318648;35470444;35513511;35580925;36010968;36284347;37217939;37689115;37938771;38561350;38601157;38648894;38656803;38665916;38838015;38977508;39196112;39534244",
        "class_list": "",
        "function": "A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation., [RefSeq, PubMed]; Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation., [UniProtKB, PubMed]; Brd4 binds to replication factor C and inhibits progression to S phase, [RefSeq, PubMed]; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Cooperative interaction of interferon regulatory factor -1 and bromodomain-containing protein 4 on RNA polymerase activation for intrinsic innate immunity. Publication Status: Online-Only, [RefSeq, PubMed]; High-altitude hypoxia promotes BRD4-mediated activation of the Wnt/beta-catenin pathway and disruption of intestinal barrier., [RefSeq, PubMed]; Interplay of condensation and chromatin binding underlies BRD4 targeting., [RefSeq, PubMed]; Targeting BRD4 mitigates hepatocellular lipotoxicity by suppressing the NLRP3 inflammasome activation and GSDMD-mediated hepatocyte pyroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 11,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 11,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 11,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 24,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 95,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 7,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60433;Q4G0X8;Q86YS8;Q96PD3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0004674 protein serine/threonine kinase activity;GO:0019899 enzyme binding;GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005694 chromosome",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 18.1,
        "record_id": "O60885-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IYF3-1",
        "uniprot_id": "TEX11_HUMAN",
        "mass": 107889.0,
        "length": 940,
        "protein_name": "Testis-expressed protein 11",
        "gene_name": "TEX11",
        "organism": "Human",
        "refseq_name": "testis-expressed protein 11 isoform 1",
        "refseq_ac": "NP_001003811",
        "gene_names_uniprotkb": "TEX11; ZIP4",
        "gene_names_refseq": "MZIP4; SPGFX2; Spo22; TEX11; TGC1; TSGA3; ZIP4H; ZIP4",
        "protein_names_uniprotkb": "Testis-expressed protein 11; Protein ZIP4 homolog; ZIP4H",
        "protein_names_refseq": "protein ZIP4 homolog; testis expressed sequence 11; testis-expressed protein 11 isoform 1; testis-expressed protein 11; testis-expressed sequence 11 protein",
        "tax_id": 9606,
        "disease": "X-linked spermatogenic failure 2 (Disease Ontology:DOID:0070185)",
        "pathway": " (hsa:56159)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "11279525;18369460;19562805;20378615;25970010;28718531;29557506;29742103;29786170;30484775;32157095;32741963;35051231;35248021;36258021;36319719;37124723",
        "class_list": "",
        "function": "Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with idiopathic azoospermia and oligospermia risk in Iranian population. Publication Status: Online-Only, [RefSeq, PubMed]; Downregulation of TEX11 promotes S-Phase progression and proliferation in colorectal cancer cells through the FOXO3a/COP1/c-Jun/p21 axis., [RefSeq, PubMed]; Hemizygous TEX11 mutations were a common cause of meiotic arrest and azoospermia in infertile men, [RefSeq, PubMed]; Novel mutations of TEX11 are associated with non-obstructive azoospermia. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers., [UniProtKB, UniProtKB]; TEX11 was specifically expressed in human testis., [RefSeq, PubMed]; Testis-expressed gene 11 inhibits cisplatin-induced DNA damage and contributes to chemoresistance in testicular germ cell tumor. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8V6;Q5JQQ8;Q96LZ4;Q96M47;Q9BXU6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000801 central element;GO:0005694 chromosome",
        "go_biological_process": "GO:0007060 male meiosis chromosome segregation;GO:0007130 synaptonemal complex assembly;GO:0007131 reciprocal meiotic recombination;GO:0006311 meiotic gene conversion",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q8IYF3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y3E2-1",
        "uniprot_id": "BOLA1_HUMAN",
        "mass": 14289.0,
        "length": 137,
        "protein_name": "BolA-like protein 1",
        "gene_name": "BOLA1",
        "organism": "Human",
        "refseq_name": "bolA-like protein 1",
        "refseq_ac": "NP_001307954",
        "gene_names_uniprotkb": "BOLA1; CGI-143",
        "gene_names_refseq": "BOLA1; CGI-143",
        "protein_names_uniprotkb": "BolA-like protein 1; hBolA",
        "protein_names_refseq": "bolA homolog 1; bolA-like 1; bolA-like protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51027)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10.1101/2023.09.13.557529;14718656;18548201;19664994;20068231;20112406;20877624;22746225;25418920;27532772;28063628;29331515;29393594;29632046;29786170;30315122;30379171;31844290;31848261;32265295;32542995;32938616;32983136",
        "class_list": "",
        "function": "Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5 (PubMed:27532772). May protect cells against oxidative stress (PubMed:22746225)., [UniProtKB, UniProtKB, PubMed, PubMed]; BOLA-like proteins are widely conserved from prokaryotes to eukaryotes and may be involved in cell proliferation or cell-cycle regulation., [RefSeq, PubMed]; Cluster exchange reactivity of [2Fe-2S]-bridged heterodimeric BOLA1-GLRX5., [RefSeq, PubMed]; Is an aerobic, mitochondrial protein that prevents mitochondrial morphology aberrations induced by GSH depletion and reduces the associated oxidative shift of the mitochondrial thiol redox potential, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; This study reported that all three human BolA proteins (hBolA1, hBolA2, and hBolA3) are novel non-classical secreted proteins identified with bioinformatics and molecular biology experiments., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7K2;D3DUZ4;Q5QNY0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:1990229 iron-sulfur cluster assembly complex",
        "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0045454 cell redox homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q9Y3E2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95503-1",
        "uniprot_id": "CBX6_HUMAN",
        "mass": 43898.0,
        "length": 412,
        "protein_name": "Chromobox protein homolog 6",
        "gene_name": "CBX6",
        "organism": "Human",
        "refseq_name": "chromobox protein homolog 6 isoform 2",
        "refseq_ac": "NP_001290423",
        "gene_names_uniprotkb": "CBX6",
        "gene_names_refseq": "CBX6",
        "protein_names_uniprotkb": "Chromobox protein homolog 6",
        "protein_names_refseq": "chromobox homolog 6; chromobox protein homolog 6 isoform 2; chromobox protein homolog 6",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162); glioblastoma (Disease Ontology:DOID:3068)",
        "pathway": " (hsa:23466);  (R-HSA-2559580);  (R-HSA-8939243);  (R-HSA-8943724);  (R-HSA-9976102)",
        "pathway_count": 5,
        "publication_count": 169,
        "publication_id_list": "10347217;10722742;10772813;10871633;11237011;11378386;11545734;11564866;11781575;11959846;12134156;12189133;12193592;12421820;12435631;12808055;13130464;14507994;14532106;15287722;15563468;15866172;16186825;16337592;16418168;16436515;16676006;16702404;16826196;16917507;17210787;17254968;17255097;17332741;17344414;17395714;17765224;17825402;17873065;17875933;17974977;18172008;18220336;18365017;18391013;18452278;18477386;18487508;18695000;18793328;18927235;19413330;19440552;19451217;19451218;19462008;19528227;19884659;20068231;20233713;20506188;20516213;21047797;21282530;21289308;21986495;22020331;22128185;22325351;22325352;22336108;22645359;22683641;23186163;23287862;23481700;23783831;24714562;24715725;24718924;25576301;25645385;25728608;26024233;26154972;26375851;26910647;26992070;27600516;27846572;27920218;28228285;28832583;28834231;28839133;28904123;29242379;29493099;29508533;29557506;29786170;30315122;30429286;30524438;30779550;30833945;31154438;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33028834;33141586;33298915;33537174;33592498;33633747;33691108;33717175;33836029;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34405274;34509645;34561969;34932366;35051231;35580925;36010968;36215666;36241641;36284347;7535770;7588633;7816143;7859739;8001816;8078588;8259215;8319905;8622669;8622688;8626550;8741839;8774846;8846784;8974401;9030721;9162092;9195981;9529249;9564042;9628874;9768359;9824166",
        "class_list": "",
        "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KAH0;Q96EM5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003727 single-stranded RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0000792 heterochromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0031507 heterochromatin formation;GO:0006325 chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 17.0,
        "record_id": "O95503-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y5K6-1",
        "uniprot_id": "CD2AP_HUMAN",
        "mass": 71451.0,
        "length": 639,
        "protein_name": "CD2-associated protein",
        "gene_name": "CD2AP",
        "organism": "Human",
        "refseq_name": "CD2-associated protein",
        "refseq_ac": "NP_036252",
        "gene_names_uniprotkb": "CD2AP",
        "gene_names_refseq": "CD2AP; CMS",
        "protein_names_uniprotkb": "CD2-associated protein; Adapter protein CMS; Cas ligand with multiple SH3 domains",
        "protein_names_refseq": "CD2-associated protein; Cas ligand with multiple Src homology (SH) 3 domains; Cas ligand with multiple Src homology 3 (SH3) domains; adapter protein CMS; cas ligand with multiple SH3 domains",
        "tax_id": 9606,
        "disease": "focal segmental glomerulosclerosis 3 (Disease Ontology:DOID:0112245); nephrotic syndrome (Disease Ontology:DOID:1184); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); tauopathy (Disease Ontology:DOID:680); end stage renal disease (Disease Ontology:DOID:783)",
        "pathway": " (hsa:23607);  (R-HSA-373753)",
        "pathway_count": 2,
        "publication_count": 120,
        "publication_id_list": "10339567;10393930;10541305;10611248;11067845;11340081;11562357;11733557;12660326;12668668;12764198;12846735;12865409;14570703;14633607;15331416;15545998;15579503;15592455;15634346;15800069;15843475;15994232;16497976;16525419;16543952;16630808;16678097;16895919;17016520;17020880;17188587;17322306;17853893;17893108;17923684;18033240;18088087;18212344;18220336;18452278;18669648;18707149;18753381;18767875;19443634;19651622;19664994;19664995;19690332;20058876;20068231;20166139;20233749;21406692;22424782;22891260;23186163;23301498;23481700;23595123;24275569;24366607;24715725;25218447;26154972;26375851;26758079;26768311;26811146;26992070;27846572;27920218;28218747;28446606;28832583;28834231;28904123;29242379;29393594;29437277;29508533;29557506;29632711;29789417;30429286;31492838;31493651;31844290;32157095;32161166;32350084;32357974;32488085;32938616;33298915;33592498;33912179;33936100;33968037;33981976;34019948;34171305;34185709;34357683;34623609;34932366;34958910;35051231;35132862;35251023;35580925;36284347;37894817;37938771;38253038;39025135;40136647;40307207;40596516",
        "class_list": "",
        "function": "Alzheimer's disease susceptibility locus in CD2AP is associated with increased cerebrospinal fluid tau levels in mild cognitive impairment., [RefSeq, PubMed]; Human cytomegalovirus pUL135 protein affects endothelial cell function via CD2AP in Kawasaki disease., [RefSeq, PubMed]; Long non-coding RNA TTC28-AS1 attenuates high glucose-induced damage in HK-2 cells depending on the regulation of miR-320a/CD2AP axis., [RefSeq, PubMed]; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Studying the Association of TKS4 and CD2AP Scaffold Proteins and Their Implications in the Partial Epithelial-Mesenchymal Transition (EMT) Process. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 28,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NL34;Q5VYA3;Q9UG97",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding;GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0030424 axon",
        "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0016477 cell migration;GO:0050808 synapse organization;GO:0051058 negative regulation of small GTPase mediated signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 12.8,
        "record_id": "Q9Y5K6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H2X0-1",
        "uniprot_id": "CHRD_HUMAN",
        "mass": 102032.0,
        "length": 955,
        "protein_name": "Chordin",
        "gene_name": "CHRD",
        "organism": "Human",
        "refseq_name": "chordin isoform 2 precursor",
        "refseq_ac": "NP_001291401",
        "gene_names_uniprotkb": "CHRD; PRO243",
        "gene_names_refseq": "CHRD",
        "protein_names_uniprotkb": "Chordin",
        "protein_names_refseq": "chordin isoform 2 precursor",
        "tax_id": 9606,
        "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); velocardiofacial syndrome (Disease Ontology:DOID:12583)",
        "pathway": " (hsa:8646)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "10648240;11237011;11472837;12975309;14759258;18452278;18533030;25157165;26517884;26811146;31844290;32350084;33968037;35051231;9782094",
        "class_list": "",
        "function": "Alternatively spliced variants have different patterns of expression to influence BMP activity in varying physiolgical situations., [RefSeq, PubMed]; Bone morphogenetic protein (BMP) chordin is produced endogenously during osteogenic differentiation of human mesenchymal stem cells (MSCs); blockade of bone morphogenetic inhibitor chordin increases the rate of osteogenic differentiation of MSCs in vitro., [RefSeq, PubMed]; C-terminal chordin domains play an important role in Bone morphogenetic protein regulation., [RefSeq, PubMed]; Data suggest CHRD (chordin) cleavage by tolloid-like metalloproteinases is insufficient to regulate BMP(bone morphogenetic protein)/BMPR signaling; CHRD fragments and TSG (twisted gastrulation protein) contribute to inhibition of BMP/BMPR signaling. Review article, [RefSeq, PubMed]; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95254;Q2M1I8;Q6UW83;Q9H2D3;Q9H2W8;Q9H2W9;Q9P0Z2;Q9P0Z3;Q9P0Z4;Q9P0Z5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019955 cytokine binding;GO:0036122 BMP binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region",
        "go_biological_process": "GO:0021513 spinal cord dorsal/ventral patterning;GO:0045785 positive regulation of cell adhesion;GO:0030336 negative regulation of cell migration;GO:0001501 skeletal system development;GO:0030509 BMP signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q9H2X0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UJY4-1",
        "uniprot_id": "GGA2_HUMAN",
        "mass": 67150.0,
        "length": 613,
        "protein_name": "ADP-ribosylation factor-binding protein GGA2",
        "gene_name": "GGA2",
        "organism": "Human",
        "refseq_name": "ADP-ribosylation factor-binding protein GGA2",
        "refseq_ac": "NP_055859",
        "gene_names_uniprotkb": "GGA2; KIAA1080",
        "gene_names_refseq": "GGA2; VEAR",
        "protein_names_uniprotkb": "ADP-ribosylation factor-binding protein GGA2; Gamma-adaptin-related protein 2; Golgi-localized, gamma ear-containing, ARF-binding protein 2; VHS domain and ear domain of gamma-adaptin; Vear",
        "protein_names_refseq": "ADP-ribosylation factor-binding protein GGA2; VHS domain and ear domain of gamma-adaptin; VHS domain and ear domain-containing protein; gamma-adaptin-related protein 2; golgi-localized, gamma ear-containing, ARF-binding protein 2",
        "tax_id": 9606,
        "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); lysosomal storage disease (Disease Ontology:DOID:3211)",
        "pathway": " (hsa:23062);  (R-HSA-8854214);  (R-HSA-977225)",
        "pathway_count": 3,
        "publication_count": 191,
        "publication_id_list": "10097139;10202141;10319874;10391242;10411933;10583407;10702286;10747088;10749927;10814529;10956649;11237011;11278841;11301005;11331584;11387475;11390366;11401442;11467836;11590439;11821067;118839;11886874;11950392;12429846;12454989;12505986;12606052;1270801;12808037;14506261;14567678;14638859;14665628;15039775;15064394;15615712;15962837;16055087;16174740;16395330;16799559;17425515;17658474;17901050;18065497;18070888;18199687;18319245;1837051;18449172;18466115;18484335;1849145;18767875;19011241;19658395;19828817;20095038;20116244;20363736;20404108;20676056;20807650;2118650;21383079;21458671;2195544;22065755;22131221;22219378;22613832;22706990;22762500;22795129;22854040;23019362;23186163;23301498;23562278;23813966;2409350;24714562;24715725;24833601;24893886;25502872;25523424;25576301;26018760;26375851;26417681;26668317;26686862;26758079;26807092;26992070;27600516;27846572;27862975;27901063;27920218;279930;28063628;28218747;28228285;28289207;28446606;28467828;28514659;28657654;28832583;28834231;28904123;2900981;29242379;29393594;29437277;29485866;29493099;29508533;29557506;29632046;29632711;29786170;30315122;3035556;30410026;30429286;3053705;30573663;30620550;30779550;3080684;3094007;31076515;31092671;31154438;31217245;3142462;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33206455;33298915;33392160;33592498;33633747;33691108;33717175;33912179;33968037;33981976;34171305;34185709;34357683;34932366;35051231;35154160;35251023;35561310;35580925;36010968;3675579;37938771;39531497;40307207;8033412;8097946;8114934;8159701;8464497;8490014;8870004;9006323;9054935;9862427",
        "class_list": "",
        "function": "GGA2 and RAB13 are important specificity determinants for integrin activity-dependent traffic. Publication Status: Online-Only, [RefSeq, PubMed]; Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting., [RefSeq, PubMed]; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712)., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DWF0;O14564;Q9NYN2;Q9UPS2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031267 small GTPase binding;GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031901 early endosome membrane;GO:0010008 endosome membrane;GO:0030136 clathrin-coated vesicle;GO:0005802 trans-Golgi network",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043001 Golgi to plasma membrane protein transport;GO:0034394 protein localization to cell surface;GO:0006893 Golgi to plasma membrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 19.6,
        "record_id": "Q9UJY4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96EV8-1",
        "uniprot_id": "DTBP1_HUMAN",
        "mass": 39493.0,
        "length": 351,
        "protein_name": "Dysbindin",
        "gene_name": "DTNBP1",
        "organism": "Human",
        "refseq_name": "dysbindin isoform C",
        "refseq_ac": "NP_001258596",
        "gene_names_uniprotkb": "DTNBP1; BLOC1S8; My031",
        "gene_names_refseq": "BLOC1S8; DBND; DTNBP1; HPS7; My031; SDY",
        "protein_names_uniprotkb": "Dysbindin; BLOC-1 subunit 8; Biogenesis of lysosome-related organelles complex 1 subunit 8; Dysbindin-1; Dystrobrevin-binding protein 1; HPS7 protein; Hermansky-Pudlak syndrome 7 protein",
        "protein_names_refseq": "BLOC-1 subunit 8; Hermansky-Pudlak syndrome 7 protein; biogenesis of lysosomal organelles complex-1, subunit 8; biogenesis of lysosome-related organelles complex 1 subunit 8; dysbindin isoform C; dysbindin-1",
        "tax_id": 9606,
        "disease": "Hermansky-Pudlak syndrome 7 (Disease Ontology:DOID:0060545); platelet storage pool deficiency (Disease Ontology:DOID:2223); temporal lobe epilepsy (Disease Ontology:DOID:3328); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); schizophrenia (Disease Ontology:DOID:5419); metal metabolism disorder (Disease Ontology:DOID:896)",
        "pathway": " (hsa:84062);  (R-HSA-432722)",
        "pathway_count": 2,
        "publication_count": 72,
        "publication_id_list": "10394364;11230166;11237011;11316798;11590181;11604418;11694590;11994746;12098102;12923531;15102850;15124027;15345706;16155256;16837549;16980328;17116749;17182842;17989303;18452278;18669648;19094965;19142223;19349376;19428785;19617633;19690332;20180862;20921223;21390302;22203680;23186163;23481700;24275569;26992070;27920218;28514659;28832583;28834231;29242379;29331515;29786170;30062698;30315122;30379171;30833945;31530632;31844290;31998317;32157095;32350084;32488085;32502341;32938616;32983136;33912179;33968037;34087483;35561310;35580925;36010968;36241641;37217939;37218669;37480305;38097925;38253038;38532008;40596516;8374173;8524399;8670264",
        "class_list": "",
        "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Dopaminergic signalling and behavioural alterations by Comt-Dtnbp1 genetic interaction and their clinical relevance., [RefSeq, PubMed]; In mouse, dysbindin binds to alpha- and beta-dystrobrevin in muscle and brain., [RefSeq, PubMed]; SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3, DYSBINDIN-1 AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A PANSS-BASED FOLLOW UP STUDY., [RefSeq, PubMed]; Sex dimorphism controls dysbindin-related cognitive dysfunctions in mice and humans with the contribution of COMT., [RefSeq, PubMed]; Single-nucleotide polymorphisms within the gene DTNBP1 (dystrobrevin-binding protein 1, or dysbindin) are strongly associated with schizophrenia Erratum:[Am J Hum Genet 2002 Oct;72(4):1007], [RefSeq, PubMed]; This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Unraveling Hermansky-Pudlak syndrome type 7: a case report and comprehensive literature review on the identification of DTNBP1 variants. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3V3;Q5THY3;Q5THY4;Q96NV2;Q9H0U2;Q9H3J5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0031175 neuron projection development;GO:0014059 regulation of dopamine secretion;GO:0048812 neuron projection morphogenesis;GO:0030036 actin cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 7.6,
        "record_id": "Q96EV8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7L1Q6-1",
        "uniprot_id": "5MP2_HUMAN",
        "mass": 48043.0,
        "length": 419,
        "protein_name": "eIF5-mimic protein 2",
        "gene_name": "BZW1",
        "organism": "Human",
        "refseq_name": "eIF5-mimic protein 2 isoform 1",
        "refseq_ac": "NP_001193996",
        "gene_names_uniprotkb": "BZW1; 5MP2; BZAP45; KIAA0005",
        "gene_names_refseq": "5MP2; BZAP45; BZW1; Nbla10236",
        "protein_names_uniprotkb": "eIF5-mimic protein 2; Basic leucine zipper and W2 domain-containing protein 1; Protein Orf",
        "protein_names_refseq": "basic leucine zipper and W2 domain-containing protein 1; basic leucine-zipper protein BZAP45; eIF5-mimic protein 2 isoform 1; eIF5-mimic protein 2; putative protein product of Nbla10236",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9689)",
        "pathway_count": 1,
        "publication_count": 119,
        "publication_id_list": "11237011;11524015;16964243;17081983;18318008;19446954;19690332;20068231;21406692;21745818;22424782;22544926;22869377;23186163;23481700;24366607;24714562;25418920;25505266;25576301;25645385;25810538;25880248;25892735;26154972;26375851;26728094;26992070;27397612;27543614;27600516;27846572;27862975;27920218;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29470543;29493099;29508533;29557506;29632711;29769354;29786170;29789417;30192525;30315122;30410026;30429286;30484775;30524438;30573663;30779550;31154438;31217245;31222486;31530632;31844290;31848261;31998317;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33091337;33123756;33141586;33214551;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34260931;34357683;34509645;34561969;34725712;34932366;34951995;35051231;35154160;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37828427;37938771;38306570;38501421;38665916;40914422",
        "class_list": "",
        "function": "Activation of BZW1 by CEBPB in macrophages promotes eIF2alpha phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice. Publication Status: Online-Only, [RefSeq, PubMed]; BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2alpha Phosphorylation., [RefSeq, PubMed]; BZW1 is a novel factor, promoting the growth of MEC cells, [RefSeq, PubMed]; BZW1 is a prognostic and immunological biomarker in pancreatic adenocarcinoma., [RefSeq, PubMed]; Stimulates cell cycle regulation of histone H4 gene transcription., [RefSeq, PubMed]; Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:29470543, PubMed:34260931). Enhances histone H4 gene transcription but does not seem to bind DNA directly (PubMed:11524015)., [UniProtKB, PubMed, PubMed, PubMed]; [Overexpression of BZW1 promotes invasion and metastasis of gastric cancer cells by regulating Wnt/beta-catenin signaling and promoting epithelial-mesenchymal transition]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DLZ8;B4DWF7;Q14281;Q15394;Q9BUY0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006446 regulation of translational initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "Q7L1Q6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P78358-1",
        "uniprot_id": "CTG1B_HUMAN",
        "mass": 17992.0,
        "length": 180,
        "protein_name": "Cancer/testis antigen 1",
        "gene_name": "CTAG1A; CTAG1B",
        "organism": "Human",
        "refseq_name": "cancer/testis antigen 1",
        "refseq_ac": "NP_001318",
        "gene_names_uniprotkb": "CTAG1A; CTAG1B; CTAG1; CTAG; ESO1; LAGE2A; LAGE2B; LAGE2",
        "gene_names_refseq": "CT6.1; CTAG1B; CTAG1; CTAG; ESO1; LAGE-2; LAGE2B; NY-ESO-1",
        "protein_names_uniprotkb": "Cancer/testis antigen 1; Autoimmunogenic cancer/testis antigen NY-ESO-1; CT6.1; Cancer/testis antigen 6.1; L antigen family member 2; LAGE-2",
        "protein_names_refseq": "New York esophageal squamous cell carcinoma 1; autoimmunogenic cancer/testis antigen NY-ESO-1; cancer antigen 3; cancer/testis antigen 1; cancer/testis antigen 6.1; l antigen family member 2",
        "tax_id": 9606,
        "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:1485);  (hsa:246100)",
        "pathway_count": 2,
        "publication_count": 89,
        "publication_id_list": "10523621;11237011;11709543;11970981;12065688;15004033;15128778;15723046;15837811;16160911;16339586;16600963;17644531;18424733;18809922;19307587;20053942;20068231;22549784;23609828;25538264;26500235;26885372;26903513;27853637;27869121;28536262;28637663;28724801;29588318;29653982;30348802;30573690;30626427;30700903;30815394;31015344;31429579;31651363;31690351;31727154;31844290;31941832;32184297;32211314;32310221;32314731;32737142;32913031;32938616;32967941;32983136;33466646;33665637;33833762;33836029;34270940;34845972;34853077;34919442;35037229;35338087;35428705;35736245;35768164;35853277;35874702;36032094;36159589;36426971;36603407;36612246;36727538;36768214;37156551;37193826;37280206;37300490;37586765;37857483;38336680;38410235;38653798;38733699;38956325;9050879;9432985;9626360;9759882",
        "class_list": "",
        "function": "Clinicopathological assessment of cancer/testis antigens NYESO1 and MAGEA4 in osteosarcoma. Publication Status: Online-Only, [RefSeq, PubMed]; Evaluation of Production Protocols for the Generation of NY-ESO-1-Specific T Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of CTAG1B clone EPR13780 versus DDIT3 gene rearrangement distinguishes myxoid liposarcoma from its mimics with detection of novel DDIT3 gene copy number variations., [RefSeq, PubMed]; Gene of the month: cancer testis antigen gene 1b (NY-ESO-1). Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. [provided by RefSeq, Jan 2012]., [RefSeq]; The role of PRAME and NY-ESO-1 as potential therapeutic and prognostic biomarkers in triple-negative breast carcinomas., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L417;B7WNL9;Q7LBY4;Q9NY13",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0070525 tRNA threonylcarbamoyladenosine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "P78358-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UNI6-1",
        "uniprot_id": "DUS12_HUMAN",
        "mass": 37687.0,
        "length": 340,
        "protein_name": "Dual specificity protein phosphatase 12",
        "gene_name": "DUSP12",
        "organism": "Human",
        "refseq_name": "dual specificity protein phosphatase 12",
        "refseq_ac": "NP_009171",
        "gene_names_uniprotkb": "DUSP12",
        "gene_names_refseq": "DUSP12; DUSP1; YVH1",
        "protein_names_uniprotkb": "Dual specificity protein phosphatase 12; 3.1.3.16; 3.1.3.48; Dual specificity tyrosine phosphatase YVH1",
        "protein_names_refseq": "YVH1 protein-tyrosine phosphatase ortholog; dual specificity protein phosphatase 12; dual specificity tyrosine phosphatase YVH1; serine/threonine specific protein phosphatase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11266)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10446167;11237011;16936214;18269685;18973475;20068231;21521943;22223895;23186163;24531476;24987109;27702885;27856639;28228285;28832583;28904123;30779967;31217245;31844290;32350084;33912179;33968037;33981976",
        "class_list": "",
        "function": "A significant decrease in DUSP12 expression in hypertrophic hearts and cardiomyocytes., [RefSeq, PubMed]; Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476)., [UniProtKB, PubMed, UniProtKB, PubMed]; HYVH1 is a novel cell survival phosphatase that co-operates with Hsp70 to positively affect cell viability in response to cellular insults., [RefSeq, PubMed]; Network analysis of DUSP12 partners in the nucleus under genotoxic stress., [RefSeq, PubMed]; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]; Our data suggest that sequences in or upstream of DUSP12 may contribute to type 2 diabetes susceptibility, but the lack of replication suggests a small effect size. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]., [RefSeq]; These results propagate a role for dual specificity phosphatases at RNP particles and suggest that hYVH1 may affect a variety of fundamental cellular processes by regulating messenger ribonucleoprotein (mRNP) dynamics., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VXA8",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.21;3.1.3.18;3.1.3.-;3.1.3.5;3.1.3.2;2.7.10.1;3.1.3.67;3.1.3.53;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0019900 kinase binding;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0036211 protein modification process;GO:0016311 dephosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q9UNI6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P35226-1",
        "uniprot_id": "BMI1_HUMAN",
        "mass": 36949.0,
        "length": 326,
        "protein_name": "Polycomb complex protein BMI-1",
        "gene_name": "BMI1",
        "organism": "Human",
        "refseq_name": "COMMD3-BMI1 read-through protein",
        "refseq_ac": "NP_001190991",
        "gene_names_uniprotkb": "BMI1; PCGF4; RNF51",
        "gene_names_refseq": "COMMD3-BMI1; PCGF4; RNF51",
        "protein_names_uniprotkb": "Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51",
        "protein_names_refseq": "COMMD3-BMI1 read-through protein; Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51",
        "tax_id": 9606,
        "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); colorectal carcinoma (Disease Ontology:DOID:0080199); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal Wilms' tumor (Disease Ontology:DOID:5176); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)",
        "pathway": " (hsa:100532731);  (hsa:648);  (R-HSA-2559580);  (R-HSA-3108214);  (R-HSA-3899300);  (R-HSA-4551638);  (R-HSA-4570464);  (R-HSA-4655427);  (R-HSA-8939243);  (R-HSA-8943724);  (R-HSA-8953750);  (R-HSA-9976102)",
        "pathway_count": 12,
        "publication_count": 278,
        "publication_id_list": "10347217;10574707;10722742;10772813;10871633;11171983;11237011;11378386;11477070;11545734;11564866;11735126;11781575;11792325;11842083;11889051;11959846;11960997;12004135;12032081;12134156;12150977;12167701;12189133;12193592;12196509;12421820;12435631;12529333;12679040;12718889;12808055;12909625;13130464;14507994;14532106;14578449;14701874;15014447;15082759;15161980;15175327;15199155;15287722;15355988;15386022;15536069;15563468;15592428;15608651;15766567;15823533;15829507;15866172;15897469;15940266;15958389;15959518;15976810;16030353;16098147;16186825;16337592;16359901;16418168;16436515;16478998;16608850;16626738;16676006;16688858;16702404;16714294;16757475;16810316;16826196;16882984;16917507;17001316;17018294;17079232;17081983;17081986;17210787;17254968;17255097;17298944;17332741;17344414;17369852;17395714;17535915;17600109;17693435;17765224;17803295;17825402;17873065;17875933;17942393;17974977;18082607;18172008;18211901;18339323;18365017;18391013;18408014;18452278;18487508;18488044;18562691;18625722;18628979;18691969;18695000;18708356;18762900;18793328;19240082;19287951;19440552;19450230;19451217;19451218;19462008;19528227;19596686;19615980;19622798;19636380;19651622;19691289;19706679;19779455;19884659;19956565;19995069;20016594;20016603;20068231;20098713;20176810;20190268;20233713;20351170;20417598;20506188;20516213;20676127;20705237;20797632;20797634;21098080;21147198;21284855;21289308;21338522;21527249;21550342;21596310;21647297;21772249;21986495;22020331;22128185;22325351;22325352;22336108;22402492;22424782;22467880;22493095;22508508;22635276;22661230;22683641;22713328;22751501;22825850;23092970;23287862;23404503;23481700;23673342;23750026;23871147;23954429;24027577;24068740;24369422;24627085;24715725;24718924;24782567;25114211;25218447;25355358;25391492;25418920;25469497;25576301;25704882;25728608;25800734;26151332;26910647;27068747;27827373;27846572;27920218;28063628;28228285;28270146;28714959;28832583;28834231;29242379;29393594;29485866;29508533;29557506;29632046;29680296;29786170;30315122;31291378;31844290;31848261;31937595;31998317;32157095;32357974;32387766;32502341;33141586;33298915;33936100;33968037;35051231;36284347;40307207;40596516;7535770;7588633;7623816;7816143;7859739;8001816;8078588;8259215;8268912;8319905;8390036;8622669;8622688;8626550;8741839;8774846;8846784;8974401;9030721;9121482;9162092;9195981;9199346;9412458;9452416;9501179;9529249;9564042;9628874;9689056;9704927;9756909;9768359;9824166;9885291",
        "class_list": "",
        "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16030;Q5T8Z3;Q96F37",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0097027 ubiquitin-protein transferase activator activity;GO:0071535 RING-like zinc finger domain binding;GO:1990841 promoter-specific chromatin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0000785 chromatin",
        "go_biological_process": "GO:0033092 positive regulation of immature T cell proliferation in thymus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 28.2,
        "record_id": "P35226-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UKL3-1",
        "uniprot_id": "C8AP2_HUMAN",
        "mass": 222658.0,
        "length": 1982,
        "protein_name": "CASP8-associated protein 2",
        "gene_name": "CASP8AP2",
        "organism": "Human",
        "refseq_name": "CASP8-associated protein 2",
        "refseq_ac": "NP_001131139",
        "gene_names_uniprotkb": "CASP8AP2; FLASH; KIAA1315; RIP25",
        "gene_names_refseq": "CASP8AP2; CED-4; FLASH; RIP25",
        "protein_names_uniprotkb": "CASP8-associated protein 2; FLICE-associated huge protein",
        "protein_names_refseq": "CASP8-associated protein 2; FLASH homolog RIP25; FLICE associated huge; FLICE-associated huge protein; human FLASH",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9994);  (R-HSA-3899300)",
        "pathway_count": 2,
        "publication_count": 101,
        "publication_id_list": "10537104;11237011;11477070;11842083;12150977;12477726;12529333;12679040;12718889;15592525;15698540;15766567;15958389;15976810;16098147;16757475;17003125;17079232;17081986;17245429;17298944;17369852;17525332;17535915;17803295;17942393;18082607;18211901;18339323;18488044;19240082;19546234;19596686;19615980;19651622;19854135;19995069;20068231;20098713;20176810;20676127;21338522;21527249;22467880;22713328;23086935;23186163;23404503;23481700;23673342;25114211;25218447;25576301;25800734;25892735;26992070;27600516;28218747;28832583;28834231;28904123;29242379;29351928;29437277;29493099;29557506;29632711;29769354;30379171;30429286;31154438;31844290;32157095;32357974;32367068;32387766;32488085;32804017;32897882;32910455;32938616;32983136;33141586;33298915;33537174;33592498;33936100;33968037;33981976;34087483;34171305;34405274;34509645;35051231;35139734;35580925;36010968;36162009;36215666;36241641;36252816",
        "class_list": "",
        "function": "CRISPRi screening identifies CASP8AP2 as an essential viability factor in lung cancer controlling tumor cell death via the AP-1 pathway., [RefSeq, PubMed]; Endogenous caspase-8 mediates tumor necrosis factor-alpha-induced activation of NF-kappaB via FLASH, [RefSeq, PubMed]; Interaction between CASP8AP2 and ZEB2-CtBP2 Regulates the Expression of LEF1., [RefSeq, PubMed]; Interaction of E2F3a and CASP8AP2 Regulates Histone Expression and Chemosensitivity of Leukemic Cells., [RefSeq, PubMed]; Knockout of the caspase 8-associated protein 2 gene improves recombinant protein expression in HEK293 cells through up-regulation of the cyclin-dependent kinase inhibitor 2A gene., [RefSeq, PubMed]; Low expression of CTBP2 and CASP8AP2 predicts risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a retrospective cohort study., [RefSeq, PubMed]; Participates in TNF-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Involved for histone gene transcription and progression through S phase: required for the generation of mature histone mRNAs following the 3' end cleavage of histone pre-mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RUB7;E1P553;Q6PH76;Q7LCQ7;Q86YD9;Q9NUQ4;Q9NZV9;Q9P2N1;Q9Y563",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0005123 death receptor binding;GO:0016505 peptidase activator activity involved in apoptotic process;GO:0032184 SUMO polymer binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016605 PML body",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0097190 apoptotic signaling pathway;GO:0071260 cellular response to mechanical stimulus;GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors",
        "synthesized_glycan_count": 0,
        "hit_score": 10.6,
        "record_id": "Q9UKL3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6NZY4-1",
        "uniprot_id": "ZCHC8_HUMAN",
        "mass": 78577.0,
        "length": 707,
        "protein_name": "Zinc finger CCHC domain-containing protein 8",
        "gene_name": "ZCCHC8",
        "organism": "Human",
        "refseq_name": "zinc finger CCHC domain-containing protein 8 isoform 1",
        "refseq_ac": "NP_060082",
        "gene_names_uniprotkb": "ZCCHC8",
        "gene_names_refseq": "PFBMFT5; ZCCHC8",
        "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 8; TRAMP-like complex RNA-binding factor ZCCHC8",
        "protein_names_refseq": "TRAMP-like complex RNA-binding factor ZCCHC8; zinc finger CCHC domain-containing protein 8 isoform 1; zinc finger, CCHC domain containing 8",
        "tax_id": 9606,
        "disease": "pulmonary fibrosis and/or bone marrow failure, telomere-related, 5 (MONDO:MONDO:0032865)",
        "pathway": " (hsa:55596);  (R-HSA-9843970);  (R-HSA-9930044)",
        "pathway_count": 3,
        "publication_count": 81,
        "publication_id_list": "11237011;11991638;15302935;16263084;16964243;17081983;17174896;17412707;17525332;18212344;18669648;18707149;18767875;19413330;19415658;19651622;19664994;19664995;19690332;20068231;20871592;21705430;21855801;22022377;22658674;22817747;23186163;23301498;23481700;24275569;24714562;25418920;25578728;26022416;26992070;27434818;27732843;27871484;27905398;27920218;28218747;28581500;28832583;28834231;28904123;29211708;29242379;29298432;29351928;29437277;29557506;29728366;29844170;29906447;30410026;31154438;31217245;31488579;31844290;31950173;32157095;32387766;32488085;32897882;32938616;32976585;32983136;33009411;33717175;33767452;33913806;33968037;34932366;35051231;35132862;35580925;36010968;36284347;37875486;38606545;40914422",
        "class_list": "",
        "function": "Expanding the understanding of telomere biology disorder with reports from two families harboring variants in ZCCHC8 and TERC., [RefSeq, PubMed]; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579)., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]., [RefSeq]; Zcchc8 is a glycogen synthase kinase-3 substrate with a role in RNA metabolism, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 20,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7L2P6;Q8N2K5;Q96SK7;Q9NSS2;Q9NSS3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0031499 TRAMP complex",
        "go_biological_process": "GO:0006396 RNA processing;GO:0000398 mRNA splicing, via spliceosome;GO:0031124 mRNA 3'-end processing;GO:0006401 RNA catabolic process;GO:0016076 snRNA catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "Q6NZY4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P01106-2",
        "uniprot_id": "MYC_HUMAN",
        "mass": 50565.0,
        "length": 454,
        "protein_name": "Myc proto-oncogene protein",
        "gene_name": "MYC",
        "organism": "Human",
        "refseq_name": "myc proto-oncogene protein isoform 1",
        "refseq_ac": "NP_002458",
        "gene_names_uniprotkb": "MYC; BHLHE39",
        "gene_names_refseq": "MRTL; MYCC; MYC; bHLHe39; c-Myc",
        "protein_names_uniprotkb": "Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; Proto-oncogene c-Myc; Transcription factor p64; bHLHe39",
        "protein_names_refseq": "avian myelocytomatosis viral oncogene homolog; class E basic helix-loop-helix protein 39; myc proto-oncogene protein isoform 1; myc proto-oncogene protein; myc-related translation/localization regulatory factor; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog",
        "tax_id": 9606,
        "disease": "angiosarcoma (Disease Ontology:DOID:0001816); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); polycystic kidney disease 1 (Disease Ontology:DOID:0110858); prostate cancer (Disease Ontology:DOID:10283); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); osteoporosis (Disease Ontology:DOID:11476); leiomyoma (Disease Ontology:DOID:127); brain cancer (Disease Ontology:DOID:1319); lung cancer (Disease Ontology:DOID:1324); hyperparathyroidism (Disease Ontology:DOID:13543); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); hepatitis C (Disease Ontology:DOID:1883); nephroblastoma (Disease Ontology:DOID:2154); prostate adenocarcinoma (Disease Ontology:DOID:2526); demyelinating disease (Disease Ontology:DOID:3213); rhabdoid cancer (Disease Ontology:DOID:3672); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); coronary restenosis (Disease Ontology:DOID:4247); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); pancreatic carcinoma (Disease Ontology:DOID:4905); liver cirrhosis (Disease Ontology:DOID:5082); prolactinoma (Disease Ontology:DOID:5394); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); Burkitt lymphoma (Disease Ontology:DOID:8584); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:4609);  (R-HSA-1362277);  (R-HSA-201556);  (R-HSA-2122947);  (R-HSA-2173796);  (R-HSA-2644606);  (R-HSA-2894862);  (R-HSA-4411364);  (R-HSA-5687128);  (R-HSA-5689880);  (R-HSA-6785807);  (R-HSA-69202);  (R-HSA-69656);  (R-HSA-8866911);  (R-HSA-8951430);  (R-HSA-9018519);  (R-HSA-9616222);  (R-HSA-9764562);  (R-HSA-9818749);  (R-HSA-9909649)",
        "pathway_count": 20,
        "publication_count": 671,
        "publication_id_list": 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        "class_list": "",
        "function": "ADAMTS4 exacerbates lung cancer progression via regulating c-Myc protein stability and activating MAPK signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Alternative translation initiation from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site results in the production of two isoforms with distinct N-termini., [RefSeq, PubMed]; METTL3 Regulates the Translation of Oncogene Myc through m[6]A Modification and Promotes the Occurrence and Development of Cervical Cancer., [RefSeq, PubMed]; Regulation of lipid and serine metabolism by the oncogene c-Myc. Review article, [RefSeq, PubMed]; TRIM40 interacts with ROCK1 directly and inhibits colorectal cancer cell proliferation through the c-Myc/p21 axis., [RefSeq, PubMed]; This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]., [RefSeq]; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 28,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 56,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 35,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A024R9L7;A0A087WUS5;A8WFE7;H0YBT0;P01107;Q14026",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005819 spindle;GO:0030424 axon",
        "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0032204 regulation of telomere maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 67.5,
        "record_id": "P01106-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BXF9-1",
        "uniprot_id": "TEKT3_HUMAN",
        "mass": 56636.0,
        "length": 490,
        "protein_name": "Tektin-3",
        "gene_name": "TEKT3",
        "organism": "Human",
        "refseq_name": "tektin-3",
        "refseq_ac": "NP_114104",
        "gene_names_uniprotkb": "TEKT3",
        "gene_names_refseq": "SPGF81; TEKT3",
        "protein_names_uniprotkb": "Tektin-3",
        "protein_names_refseq": "tektin-3; testicular microtubules-related protein",
        "tax_id": 9606,
        "disease": "spermatogenic failure 81 (Disease Ontology:DOID:0070580)",
        "pathway": " (hsa:64518)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;29242379;36191189;36708031;39894887",
        "class_list": "",
        "function": "Bi-allelic human TEKT3 mutations cause male infertility with oligoasthenoteratozoospermia owing to acrosomal hypoplasia and reduced progressive motility., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme (PubMed:36191189). Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Required for normal sperm mobility (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 9,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RAS7;D3DTT0;Q8N5R5;Q96M48",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0070062 extracellular exosome;GO:0015630 microtubule cytoskeleton;GO:0001669 acrosomal vesicle",
        "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0060378 regulation of brood size;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q9BXF9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H159-1",
        "uniprot_id": "CAD19_HUMAN",
        "mass": 87002.0,
        "length": 772,
        "protein_name": "Cadherin-19",
        "gene_name": "CDH19",
        "organism": "Human",
        "refseq_name": "cadherin-19 isoform 2 preproprotein",
        "refseq_ac": "NP_001257957",
        "gene_names_uniprotkb": "CDH19; CDH7L2; PRO941",
        "gene_names_refseq": "CDH19; CDH7L2; CDH7",
        "protein_names_uniprotkb": "Cadherin-19",
        "protein_names_refseq": "cadherin 19, type 2; cadherin-19 isoform 2 preproprotein",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:28513);  (R-HSA-9764302)",
        "pathway_count": 2,
        "publication_count": 18,
        "publication_id_list": "10995570;11237011;12975309;18364357;23090970;24008336;24190977;25361488;27600516;28904123;29557506;31844290;32157095;32488085;33968037;34078123;35580925;38052007",
        "class_list": "",
        "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB]; Gene expression profiling of Glioblastoma stem-like cells has shown CDH19 to be an exciting new target for drug development and study of glioblastoma multiforme tumorigenesis, [RefSeq, PubMed]; The cadherin protein CDH19 mediates cervical carcinoma progression by regulating AKT/NF-kappaB signaling., [RefSeq, PubMed]; This gene is one of three related type II cadherin genes situated in a cluster on chromosome 18. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein containing five extracellular cadherin repeats. Loss of cadherins may be associated with cancer formation. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2012]., [RefSeq]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 55,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E1V5;F5H1K0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016342 catenin complex",
        "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q9H159-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P21796-1",
        "uniprot_id": "VDAC1_HUMAN",
        "mass": 30773.0,
        "length": 283,
        "protein_name": "Non-selective voltage-gated ion channel VDAC1",
        "gene_name": "VDAC1",
        "organism": "Human",
        "refseq_name": "non-selective voltage-gated ion channel VDAC1 isoform 1",
        "refseq_ac": "NP_003365",
        "gene_names_uniprotkb": "VDAC1; VDAC",
        "gene_names_refseq": "PORIN; VDAC-1; VDAC1",
        "protein_names_uniprotkb": "Non-selective voltage-gated ion channel VDAC1; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM; VDAC-1; Voltage-dependent anion-selective channel protein 1; hVDAC1",
        "protein_names_refseq": "non-selective voltage-gated ion channel VDAC1 isoform 1; non-selective voltage-gated ion channel VDAC1; outer mitochondrial membrane protein porin 1; plasmalemmal porin; porin 31HL; porin 31HM; sperm binding protein 1a",
        "tax_id": 9606,
        "disease": "Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); retinal degeneration (Disease Ontology:DOID:8466)",
        "pathway": " (hsa:7416);  (R-HSA-1268020);  (R-HSA-5205685);  (R-HSA-5689880);  (R-HSA-70268);  (R-HSA-8949215)",
        "pathway_count": 6,
        "publication_count": 307,
        "publication_id_list": "10.1101/2023.09.13.557529;10444327;10501981;10661876;10772903;10982817;11237011;11276087;11377399;11566882;11845315;11863375;11923872;11945601;12121650;12438411;12917689;12917691;12962632;14596586;14661020;14726512;15033708;15053880;15254020;15302935;15551868;15592455;15644312;15683237;15870898;15904662;15916963;16185709;16201016;16214042;16565220;1657034;16849325;16901786;16964248;17081983;17178908;17290220;17443180;17510655;17873522;17980597;17981138;18083107;18088087;18172164;18174896;18351441;18467330;18628306;18632802;18636086;18669648;18678864;18691976;18707149;18755977;18767875;18832158;19007248;19015242;19135894;19188362;1931970;1935931;19363159;19398555;19409522;19413330;19415658;19424180;19432818;19453276;19608861;19651622;19664994;19679512;19691289;19767391;19797662;19838211;19874889;19910467;1993674;19962426;1996957;20018762;20058876;20068231;20096447;20126261;20166139;20228808;20230784;20368735;20501646;20593814;20693986;20712405;21115803;21156174;21194381;21239494;21362556;21571647;21596315;21617041;21659512;21685886;21685888;21720385;21750375;21849505;21962518;22029577;22085928;22128162;22216260;22223895;22304920;22628558;22645359;23041349;23055042;23159851;23186163;23284632;23395819;23409044;23486064;23576270;23597483;23716663;23755363;23811401;23824326;23825189;23900286;24056413;24162235;24231807;24260525;24344246;2440048;24493797;24503055;24560927;24660806;24751536;24784582;24896179;24898248;24970796;24998673;25077561;25168729;25171321;25197364;25202825;25296756;25305019;25315652;25418920;25474007;25502872;25527497;25565209;25575590;25576301;25578727;25594249;2559745;25621951;25645385;25753332;25880248;26116755;26154972;26365381;26387735;26697887;26811146;26976564;26992070;27035970;27099988;27166188;27247382;27317664;27452731;27600516;27641616;27669901;27846572;27920218;28218747;28228285;28514659;28657654;28832583;28834231;28904123;29242379;29314611;29393594;29394115;29437277;29472561;29493099;29508533;29557506;29632046;29632711;29774024;29995846;30061676;30315122;30352685;30397120;30410026;30626607;30833945;31015432;31020640;31154438;31206022;31217245;31530632;31611695;31844290;31848261;32047033;32119511;32157095;32161166;32265295;32296703;32350084;32357974;32387766;32403431;32488085;32502341;32897882;32938616;32983136;33043033;33064660;33123756;33141586;33214551;33298915;33592498;33633747;33717175;33912179;33936100;33968037;34078123;34087483;34171305;3435492;34357683;34433824;34509645;34561969;34725712;34932366;35051231;35154160;35251023;35561310;35580925;35958281;36010968;36215666;36241641;36284347;36417180;37074911;37702230;37717471;37737517;37938771;38065946;38070860;38287189;38665916;40596516;40914422;4822737;7399049;7539795;7578059;7685903;7757881;7818469;8420959;8726225;9119391;9705294",
        "class_list": "",
        "function": "Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids., [UniProtKB, PubMed, UniProtKB, UniProtKB]; HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma., [RefSeq, PubMed]; Identification and validation of voltage-dependent anion channel 1-related genes and immune cell infiltration in diabetic nephropathy., [RefSeq, PubMed]; Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1., [RefSeq, PubMed]; Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The inhibition of VDAC1 oligomerization promotes pigmentation through the CaMK-CRTCs/CREB-MITF pathway., [RefSeq, PubMed]; This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 5,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVK4;D3DQ93;Q5FVE7;Q9UIQ5;Q9UPL0",
        "ec_number_list": "1.8.-.-;1.8.5.1;3.1.-.-;1.11.1.-;5.6.1.6;2.7.11.1;1.6.5.5",
        "go_molecular_function": "GO:0008142 oxysterol binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:1901526 positive regulation of mitophagy;GO:0006869 lipid transport;GO:0030855 epithelial cell differentiation;GO:0043066 negative regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 31.4,
        "record_id": "P21796-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P78364-1",
        "uniprot_id": "PHC1_HUMAN",
        "mass": 105534.0,
        "length": 1004,
        "protein_name": "Polyhomeotic-like protein 1",
        "gene_name": "PHC1",
        "organism": "Human",
        "refseq_name": "polyhomeotic-like protein 1 isoform a",
        "refseq_ac": "NP_004417",
        "gene_names_uniprotkb": "PHC1; EDR1; PH1",
        "gene_names_refseq": "EDR1; HPH1; MCPH11; PHC1; RAE28",
        "protein_names_uniprotkb": "Polyhomeotic-like protein 1; Early development regulatory protein 1; hPH1",
        "protein_names_refseq": "early development regulator 1 (homolog of polyhomeotic 1); early development regulatory protein 1; polyhomeotic-like 1; polyhomeotic-like protein 1 isoform a",
        "tax_id": 9606,
        "disease": "primary autosomal recessive microcephaly 11 (Disease Ontology:DOID:0070287); dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162); tetralogy of Fallot (Disease Ontology:DOID:6419)",
        "pathway": " (hsa:1911);  (R-HSA-2559580);  (R-HSA-3108214);  (R-HSA-3899300);  (R-HSA-4551638);  (R-HSA-4570464);  (R-HSA-4655427);  (R-HSA-8939243);  (R-HSA-8943724);  (R-HSA-8953750);  (R-HSA-9976102)",
        "pathway_count": 11,
        "publication_count": 266,
        "publication_id_list": "10347217;10574707;10722742;10772813;10871633;11171983;11237011;11378386;11477070;11545734;11564866;11735126;11781575;11792325;11842083;11889051;11959846;11960997;12004135;12032081;12134156;12150977;12167701;12189133;12193592;12196509;12421820;12435631;12529333;12679040;12718889;12808055;12909625;13130464;14507994;14532106;14578449;14701874;15014447;15082759;15161980;15175327;15199155;15287722;15355988;15536069;15563468;15592428;15608651;15766567;15823533;15829507;15866172;15940266;15958389;15959518;15976810;16030353;16098147;16186825;16337592;16418168;16436515;16478998;16608850;16626738;16676006;16688858;16702404;16757475;16810316;16826196;16917507;17001316;17018294;17079232;17081986;17210787;17254968;17255097;17298944;17332741;17344414;17369852;17395714;17535915;17600109;17693435;17765224;17803295;17825402;17873065;17875933;17942393;17974977;18082607;18083107;18172008;18211901;18339323;18365017;18391013;18408014;18487508;18488044;18491316;18562691;18625722;18628979;18691969;18695000;18708356;18762900;18793328;19240082;19287951;19413330;19440552;19450230;19451217;19451218;19462008;19528227;19596686;19615980;19622798;19636380;19664995;19690332;19706679;19779455;19884659;19956565;19995069;20016594;20016603;20098713;20176810;20190268;20233713;20351170;20417598;20506188;20516213;20676127;20705237;20797632;20797634;21098080;21147198;21284855;21289308;21338522;21406692;21527249;21550342;21596310;21647297;21986495;22020331;22128185;22325351;22325352;22336108;22402492;22467880;22493095;22508508;22635276;22661230;22683641;22713328;22751501;22825850;23092970;23287862;23404503;23418308;23481700;23673342;23750026;23871147;23954429;24027577;24068740;24369422;24627085;24715725;24718924;24782567;25114211;25218447;25391492;25576301;25704882;25728608;25800734;26910647;27068747;27920218;28657654;28904123;29242379;29351928;29557506;29632711;30620550;31492838;31844290;32157095;32387766;32488085;32502341;32938616;33214551;33298915;33592498;33968037;33990559;34019948;35051231;35132862;35138101;35254053;35289036;35705054;36010968;37217939;37541260;38665916;39531497;39534244;40307207;7535770;7588633;7623816;7816143;7859739;8001816;8078588;8259215;8319905;8622669;8622688;8626550;8741839;8774846;8846784;8974401;9030721;9121482;9162092;9195981;9199346;9412458;9452416;9501179;9529249;9564042;9628874;9689056;9704927;9756909;9768359;9824166;9885291",
        "class_list": "",
        "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression., [UniProtKB, PubMed]; PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DUV4;Q8WVM3;Q9BU63",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0031519 PcG protein complex",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045892 negative regulation of DNA-templated transcription;GO:0031507 heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 27.8,
        "record_id": "P78364-1",
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    },
    {
        "uniprot_canonical_ac": "Q9Y426-1",
        "uniprot_id": "C2CD2_HUMAN",
        "mass": 75533.0,
        "length": 696,
        "protein_name": "C2 domain-containing protein 2",
        "gene_name": "C2CD2",
        "organism": "Human",
        "refseq_name": "C2 domain-containing protein 2 isoform 1",
        "refseq_ac": "NP_056315",
        "gene_names_uniprotkb": "C2CD2; C21orf258; C21orf25; TMEM24L",
        "gene_names_refseq": "C21orf258; C21orf25; C2CD2; TMEM24L",
        "protein_names_uniprotkb": "C2 domain-containing protein 2; Transmembrane protein 24-like",
        "protein_names_refseq": "C2 domain-containing protein 2 isoform 1; C2 domain-containing protein 2; TMEM24 related geme; transmembrane protein 24-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25966)",
        "pathway_count": 1,
        "publication_count": 36,
        "publication_id_list": "11237011;18578522;18669648;23186163;24275569;25576301;26992070;27846572;27869121;28657654;28832583;28834231;28904123;29158487;29485866;29557506;29786170;30379171;31154438;31844290;31848261;32157095;32161166;32350084;32387766;32938616;32983136;33592498;34171305;34932366;35051231;35251023;35580925;36010968;36284347;39158698",
        "class_list": "",
        "function": "A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts., [RefSeq, PubMed]; Genotyping was accomplished on Infinium Human610-QUAD version 1. In the ilSIRENTE population, genetic variants in ZNF295 and C2CD2 (rs928874 and rs1788355) on chromosome 21q22.3, were significantly associated with the 4-meter gait speed Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q5R2V7;Q6AHX8;Q9NSE6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane",
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        "record_id": "Q9Y426-1",
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    },
    {
        "uniprot_canonical_ac": "Q99743-1",
        "uniprot_id": "NPAS2_HUMAN",
        "mass": 91791.0,
        "length": 824,
        "protein_name": "Neuronal PAS domain-containing protein 2",
        "gene_name": "NPAS2",
        "organism": "Human",
        "refseq_name": "neuronal PAS domain-containing protein 2",
        "refseq_ac": "NP_002509",
        "gene_names_uniprotkb": "NPAS2; BHLHE9; MOP4; PASD4",
        "gene_names_refseq": "MOP4; NPAS2; PASD4; bHLHe9",
        "protein_names_uniprotkb": "Neuronal PAS domain-containing protein 2; Basic-helix-loop-helix-PAS protein MOP4; Class E basic helix-loop-helix protein 9; Member of PAS protein 4; Neuronal PAS2; PAS domain-containing protein 4; bHLHe9",
        "protein_names_refseq": "PAS domain-containing protein 4; basic-helix-loop-helix-PAS protein MOP4; class E basic helix-loop-helix protein 9; member of PAS protein 4; member of PAS superfamily 4; neuronal PAS domain-containing protein 2; neuronal PAS2",
        "tax_id": 9606,
        "disease": "major depressive disorder (Disease Ontology:DOID:1470)",
        "pathway": " (hsa:4862);  (R-HSA-1368108);  (R-HSA-1989781);  (R-HSA-9707616);  (R-HSA-9931509);  (R-HSA-9931510);  (R-HSA-9931521)",
        "pathway_count": 7,
        "publication_count": 103,
        "publication_id_list": "10198158;10381560;10777541;10857746;11018023;11162494;11237011;11241162;11267664;11387216;11441146;11441147;12118000;12130498;12130638;12177166;12356737;12377782;12406875;12505311;12511571;12582161;12655319;12738229;14645221;14672706;14750904;15067378;15130092;15175654;15500444;15560782;15635043;15665827;15761026;16380219;16857194;16972786;17096334;17453337;17994337;18006707;18037887;18317514;18439826;18540824;18587630;18719978;18819933;18848529;19088433;19710360;19710929;1971514;19934321;20110263;20581824;20817722;21479263;21628546;23303907;24196956;2539258;25576301;27754849;28111073;29242379;29493099;29557506;2991279;30315122;30429286;31154438;31748741;31844290;31848261;32157095;32161166;32265295;32354867;32695117;32938616;3345742;33592498;33968037;34925645;35051231;36978001;37120564;37398880;38804230;7685352;7892212;7981125;8415693;8618898;8622974;8647822;8887638;9012850;9079689;9144434;9748239",
        "class_list": "",
        "function": "Association between glucose metabolism, the circadian cycle and hypoxia: Evaluation of the NPAS2 and Rev-Erb-alpha protein serum levels in obstructive sleep apnea patients - a pilot study., [RefSeq, PubMed]; Characterization of molecular subtypes based on chromatin regulators and identification of the role of NPAS2 in lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; High expression of the circadian clock gene NPAS2 is associated with progression and poor prognosis of gastric cancer: A single-center study., [RefSeq, PubMed]; Integrative Molecular Analyses of an Individual Transcription Factor-Based Genomic Model for Lung Cancer Prognosis. Publication Status: Online-Only, [RefSeq, PubMed]; NPAS2 promotes aerobic glycolysis and tumor growth in prostate cancer through HIF-1A signaling. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability. Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes. Controls the circadian rhythm of NR0B2 expression by binding rhythmically to its promoter (By similarity). Mediates the diurnal variation in the expression of GABARA1 receptor in the brain and contributes to the regulation of anxiety-like behaviors and GABAergic neurotransmission in the ventral striatum (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]",
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        "secondary_ac_list": "Q4ZFV9;Q53SQ3;Q86V96;Q99629",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046872 metal ion binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051775 response to redox state;GO:0007417 central nervous system development;GO:0006974 DNA damage response",
        "synthesized_glycan_count": 0,
        "hit_score": 10.4,
        "record_id": "Q99743-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96CN7-1",
        "uniprot_id": "ISOC1_HUMAN",
        "mass": 32237.0,
        "length": 298,
        "protein_name": "Isochorismatase domain-containing protein 1",
        "gene_name": "ISOC1",
        "organism": "Human",
        "refseq_name": "isochorismatase domain-containing protein 1",
        "refseq_ac": "NP_057132",
        "gene_names_uniprotkb": "ISOC1; CGI-111",
        "gene_names_refseq": "CGI-111; ISOC1",
        "protein_names_uniprotkb": "Isochorismatase domain-containing protein 1",
        "protein_names_refseq": "isochorismatase domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51015)",
        "pathway_count": 1,
        "publication_count": 59,
        "publication_id_list": "11237011;18991276;22544926;23481700;24366607;24715725;25645385;26154972;26375851;26768311;26992070;27600516;27862975;27920218;28228285;28649982;28832583;28904123;29242379;29393594;29493099;29508533;29557506;29786170;30315122;30524438;30779550;31740942;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33275227;33298915;33537174;33547171;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34405274;34509645;35051231;35138101;35318648;35561310;35580925;36010968;36215666;36241641",
        "class_list": "",
        "function": "Functional Analysis of Immune Signature Genes in Th1* Memory Cells Links ISOC1 and Pyrimidine Metabolism to IFN-gamma and IL-17 Production., [RefSeq, PubMed]; ISOC1 promotes the proliferation of gastric cancer cells by positively regulating CDK19., [RefSeq, PubMed]; Knockdown of ISOC1 inhibits the proliferation and migration and induces the apoptosis of colon cancer cells through the AKT/GSK-3beta pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q7Z770",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome",
        "go_biological_process": "",
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        "record_id": "Q96CN7-1",
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    },
    {
        "uniprot_canonical_ac": "O14977-1",
        "uniprot_id": "AZIN1_HUMAN",
        "mass": 49535.0,
        "length": 448,
        "protein_name": "Antizyme inhibitor 1",
        "gene_name": "AZIN1",
        "organism": "Human",
        "refseq_name": "antizyme inhibitor 1 isoform 1",
        "refseq_ac": "NP_056962",
        "gene_names_uniprotkb": "AZIN1; OAZIN; OAZI",
        "gene_names_refseq": "AZI1; AZIA1; AZIN1; AZI; OAZIN; OAZI; ODC1L",
        "protein_names_uniprotkb": "Antizyme inhibitor 1; AZI1; AZI; Ornithine decarboxylase antizyme inhibitor",
        "protein_names_refseq": "antizyme inhibitor 1 isoform 1; ornithine decarboxylase antizyme inhibitor",
        "tax_id": 9606,
        "disease": "pneumocystosis (Disease Ontology:DOID:11339); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:51582);  (R-HSA-350562)",
        "pathway_count": 2,
        "publication_count": 96,
        "publication_id_list": "11237011;12359729;12660156;15670771;15749015;17900240;21837750;23291631;23481700;24366607;24397554;24714562;24715725;25576301;25645385;26154972;26305948;26443277;26811146;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29331515;29371260;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30315122;30410026;30429286;30524438;30779550;30833945;31092671;31217245;31222486;31530632;31844290;31848261;31937595;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34405274;34509645;34932366;35051231;35318648;35365616;35561310;35580925;35697535;36010968;36215666;36241641;36284347;36581221;37209819;37938771;7811704;9349715",
        "class_list": "",
        "function": "A novel mechanism for A-to-I RNA-edited AZIN1 in promoting tumor angiogenesis in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; ADAR1 and AZIN1 RNA editing function as an oncogene and contributes to immortalization in endometrial cancer., [RefSeq, PubMed]; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Edited form has a stronger affinity to antizyme, and the resultant higher AZIN1 protein stability promotes cell proliferation through the neutralization of antizyme-mediated degradation of ornithine decarboxylase (ODC) and cyclin D1, [RefSeq, PubMed]; Minor allelic SNP variant in 12th exon of AZIN1 associated with slower rates of fibrosis progression favors expression of novel splice form, AZIN1 SV2, that inhibits expression of fibrogenic genes in hepatic stellate cells., [RefSeq, PubMed]; RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing., [RefSeq, PubMed]; The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]., [RefSeq]; This study also suggests that highly expressed AZI may be partly responsible for increased ODC activity and cellular transformation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NCD5;Q6IBQ7;Q96D20",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004586 ornithine decarboxylase activity;GO:0042978 ornithine decarboxylase activator activity;GO:0003824 catalytic activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0042177 negative regulation of protein catabolic process;GO:0033387 putrescine biosynthetic process from arginine, via ornithine;GO:1902269 positive regulation of polyamine transmembrane transport;GO:0006596 polyamine biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.7,
        "record_id": "O14977-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q3B7T3-1",
        "uniprot_id": "BEAN1_HUMAN",
        "mass": 28626.0,
        "length": 259,
        "protein_name": "Protein BEAN1",
        "gene_name": "BEAN1",
        "organism": "Human",
        "refseq_name": "protein BEAN1 isoform 2",
        "refseq_ac": "NP_001129578",
        "gene_names_uniprotkb": "BEAN1",
        "gene_names_refseq": "BEAN1; BEAN; SCA31",
        "protein_names_uniprotkb": "Protein BEAN1; BEAN; Brain-expressed protein associating with Nedd4 homolog",
        "protein_names_refseq": "brain-expressed protein associating with Nedd4 homolog; protein BEAN1 isoform 2; protein BEAN1",
        "tax_id": 9606,
        "disease": "spinocerebellar ataxia 31 (Disease Ontology:DOID:0050980)",
        "pathway": " (hsa:146227)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;19878914;21163552;22049201;23607545;26876577",
        "class_list": "",
        "function": "Our data indicate that SCA31 is absent or rare in the Chinese population on Taiwan., [RefSeq, PubMed]; SCA31 is associated with 'inserted' pentanucleotide repeats containing (TGGAA)n., [RefSeq, PubMed]; The protein encoded by this gene is one of several proteins that interact with NEDD4, a member of a family of ubiquitin-protein ligases. These proteins have PY motifs in common that bind to the WW domains of NEDD4. NEDD4 is developmentally regulated, and is highly expressed in embryonic tissues. Mutations in this gene (i.e., intronic insertions of >100 copies of pentanucleotide repeats including a (TGGAA)n sequence) are associated with spinocerebellar ataxia type 31. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]., [RefSeq]; This study describes the structure of SCA31 pentanucleotide repeat sequences in a cohort of Caucasian patients with spinocerebellar ataxia., [RefSeq, PubMed]; This study reveals a regulation mechanism of NEDD4-1 stability by O-GlcNAcylation., [RefSeq, PubMed]; We conclude that the RNA foci containing BEAN1-direction transcript (UGGAA)n are associated with Purkinje cell degeneration in Spinocerebellar ataxia type 31, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KPC0;H3BP97",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q3B7T3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P33076-1",
        "uniprot_id": "C2TA_HUMAN",
        "mass": 123415.0,
        "length": 1130,
        "protein_name": "MHC class II transactivator",
        "gene_name": "CIITA",
        "organism": "Human",
        "refseq_name": "MHC class II transactivator isoform 2",
        "refseq_ac": "NP_000237",
        "gene_names_uniprotkb": "CIITA; MHC2TA",
        "gene_names_refseq": "C2TA; CIITAIV; CIITA; MHC2D1; MHC2TA; NLRA",
        "protein_names_uniprotkb": "MHC class II transactivator; 2.3.1.-; 2.7.11.1; CIITA",
        "protein_names_refseq": "MHC class II transactivator isoform 2; MHC class II transactivator type III; NLR family, acid domain containing; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing",
        "tax_id": 9606,
        "disease": "osteoporosis (Disease Ontology:DOID:11476); Addison's disease (Disease Ontology:DOID:13774); multiple sclerosis (Disease Ontology:DOID:2377); MHC class II deficiency (Disease Ontology:DOID:5812); myocardial infarction (Disease Ontology:DOID:5844); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); periapical periodontitis (Disease Ontology:DOID:823); systemic lupus erythematosus (Disease Ontology:DOID:9074)",
        "pathway": " (hsa:4261);  (R-HSA-877300)",
        "pathway_count": 2,
        "publication_count": 150,
        "publication_id_list": "10067896;10464099;10501838;10986460;11172716;11237011;11416140;11466404;11862382;11972023;12040185;12438563;12446674;12859996;12915721;12919287;1396683;14586410;14722222;14978097;1508672;15143187;15210796;15322115;15388922;15530433;16115862;16237089;16467876;16600381;17095509;17125875;17493635;17991736;18245089;18362138;18591661;20049711;20130243;20304997;20363976;20538595;20937824;22424782;23007646;23061660;23481700;23783831;24036077;24366607;24397554;24417533;24714562;24715725;25418920;25576301;25880248;25892735;26154972;26181363;26375851;26728094;26811146;26992070;27397612;27846572;27862975;27920218;28218747;28228285;28649982;28832583;28834231;28860189;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30379171;30484775;30524438;31154438;31530632;31844290;31848261;31937595;31998317;32157095;32357974;32387766;32488085;32502341;32855215;32897882;32938616;32983136;33123756;33141586;33239784;33298915;33592498;33717175;33912179;33936100;33968037;34087483;34211107;34509645;34932366;35051231;35318648;35561310;35580925;35835655;36215666;36223747;36241641;36581221;37108368;37467968;38073129;38253038;40608405;7510216;7514165;7530745;7615558;7617032;7657660;7673114;7690989;7749984;7796299;8156998;8176225;8402893;8483949;8530158;8550631;8631301;9111318;9143706",
        "class_list": "",
        "function": "Cancer-specific T helper shared and neo-epitopes uncovered by expression of the MHC class II master regulator CIITA. Erratum:[Cell Rep. 2022 Nov 22;41(8):111680. doi: 10.1016/j.celrep.2022.111680. PMID: 36417866], [RefSeq, PubMed]; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893, PubMed:40608405). Does not bind DNA (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:16600381, PubMed:17493635). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Exhibits dominant-negative suppression of MHC class II gene expression., [UniProtKB, PubMed]; NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity. Publication Status: Online-Only, [RefSeq, PubMed]; Novel missense variant of CIITA contributing to endometriosis., [RefSeq, PubMed]; The NLR member CIITA: Master controller of adaptive and intrinsic immunity and unexpected tool in cancer immunotherapy. Review article, [RefSeq, PubMed]; The intrinsically disordered transcriptional activation domain of CIITA is functionally tuneable by single substitutions: An exception or a new paradigm?, [RefSeq, PubMed]; This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 9,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0B4J1S1;A0N0N9;D3DUG0;E9PFE0;Q29675;Q8SNB8;Q96KL4",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.3.2.27;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.7.84;2.7.11.23;1.8.4.-;1.8.-.-;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.2.-;3.6.1.-;3.6.5.-;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.7.11.12;2.7.11.17;6.3.2.n3;2.7.11.8;2.7.11.19;4.1.1.32;2.7.11.38;2.7.11.34;3.6.-.-;2.7.1.150",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0003714 transcription corepressor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016605 PML body",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006955 immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060333 type II interferon-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 15.7,
        "record_id": "P33076-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y2A9-1",
        "uniprot_id": "B3GN3_HUMAN",
        "mass": 42534.0,
        "length": 372,
        "protein_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3",
        "gene_name": "B3GNT3",
        "organism": "Human",
        "refseq_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3",
        "refseq_ac": "NP_055071",
        "gene_names_uniprotkb": "B3GNT3; B3GALT8; PRO1266; TMEM3",
        "gene_names_refseq": "B3GAL-T8; B3GN-T3; B3GNT-3; B3GNT3; HP10328; TMEM3; beta3Gn-T3",
        "protein_names_uniprotkb": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3; 2.4.1.146; 2.4.1.149; BGnT-3; Beta-1,3-GalTase 8; Beta-1,3-Gn-T3; Beta-1,3-N-acetylglucosaminyltransferase 3; Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase; Beta-1,3-galactosyltransferase 8; Beta-3-Gx-T8; Beta3Gal-T8; Beta3GalT8; Beta3Gn-T3; Core 1 extending beta-1,3-N-acetylglucosaminyltransferase; Core1-beta3GlcNAcT; Transmembrane protein 3; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8; b3Gal-T8",
        "protein_names_refseq": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8; beta-1,3-GalTase 8; beta-1,3-Gn-T3; beta-1,3-N-acetylglucosaminyltransferase bGnT-3; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase; beta-3-Gx-T8; beta3GalT8; core 1 extending beta-1,3-N-acetylglucosaminyltransferase; core1-beta3GlcNAcT; putative type II membrane protein; transmembrane protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10331);  (R-HSA-2022854);  (R-HSA-913709);  (R-HSA-9931295)",
        "pathway_count": 4,
        "publication_count": 65,
        "publication_id_list": "10072769;10206952;10330415;10430883;10491328;10504389;10580128;10753916;11030741;11042166;11042394;11237011;11283017;11304796;11439191;11588157;11821425;11901181;12218059;12855678;12893276;12975309;1329093;15486459;15560372;15620693;17021253;17113861;1714903;17924679;18537974;22183981;24643043;25576301;25787250;27572267;29242379;29557506;29765039;29789417;30118680;30779550;31154438;31305264;33981976;34185709;35580925;35715910;35777165;36284347;36719382;36995820;38034954;7655172;8333853;8611500;8920913;9295285;9394011;9405439;9417100;9435216;9597550;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191)., [UniProtKB, PubMed, PubMed]; Study on the Expression of beta-1,3-N-acetylglucosaminyltransferase 3 in Gastric Cancer and the Mechanism Promoting Gastric Cancer Progression Based on the Extraction Method of Nanomagnetic Beads., [RefSeq, PubMed]; The role of B3GNT3 as an oncogene in the growth, invasion and migration of esophageal cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008]., [RefSeq]; Upregulation of B3GNT3 is associated with immune infiltration and activation of NF-kappaB pathway in gynecologic cancers., [RefSeq, PubMed]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 483,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RAS4;Q6NWU9;Q6NXU9;Q8WWR6;Q9C0J2",
        "ec_number_list": "2.4.1.-;2.4.1.147;2.4.1.149;2.4.1.206;2.4.1.146",
        "go_molecular_function": "GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity;GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016758 hexosyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0018146 keratan sulfate proteoglycan biosynthetic process;GO:0030311 poly-N-acetyllactosamine biosynthetic process;GO:0009101 glycoprotein biosynthetic process",
        "synthesized_glycan_count": 1046,
        "hit_score": 6.6,
        "record_id": "Q9Y2A9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95696-1",
        "uniprot_id": "BRD1_HUMAN",
        "mass": 119520.0,
        "length": 1058,
        "protein_name": "Bromodomain-containing protein 1",
        "gene_name": "BRD1",
        "organism": "Human",
        "refseq_name": "bromodomain-containing protein 1 isoform 1",
        "refseq_ac": "NP_001291737",
        "gene_names_uniprotkb": "BRD1; BRL; BRPF2",
        "gene_names_refseq": "BRD1; BRL; BRPF2",
        "protein_names_uniprotkb": "Bromodomain-containing protein 1; BR140-like protein; Bromodomain and PHD finger-containing protein 2",
        "protein_names_refseq": "BR140-like protein; bromodomain and PHD finger-containing protein 2; bromodomain-containing protein 1 isoform 1; bromodomain-containing protein 1",
        "tax_id": 9606,
        "disease": "bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419)",
        "pathway": " (hsa:23774);  (R-HSA-3214847);  (R-HSA-6804758)",
        "pathway_count": 3,
        "publication_count": 65,
        "publication_id_list": "10602503;10786633;10821277;11099047;11237011;15313887;16387653;16839880;17081983;18381289;18477386;18623064;18669648;18794358;19187765;19608861;19690332;20018852;20068231;20228809;20660729;21406692;21720545;21753189;21880731;22464331;23186163;23431171;23481700;24714562;25593309;26375851;26728094;28063628;28218747;28228285;28334966;28584052;28904123;29242379;29393594;29557506;29632046;29632711;30379171;31827282;31844290;32357974;32387766;32502341;32983136;33556623;33968037;34259319;34482774;34509645;35051231;35318648;35580925;35941107;36215666;36284347;9427644;9558366;9880483",
        "class_list": "",
        "function": "Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains., [RefSeq, PubMed]; Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples., [RefSeq, PubMed]; HBO1 is a versatile histone acyltransferase critical for promoter histone acylations., [RefSeq, PubMed]; Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189)., [UniProtKB, PubMed, PubMed, PubMed]; The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6ZJA4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140566 histone reader activity;GO:0140063 unmodified histone reader activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0070776 MOZ/MORF histone acetyltransferase complex",
        "go_biological_process": "GO:0050793 regulation of developmental process;GO:0043249 erythrocyte maturation;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045648 positive regulation of erythrocyte differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "O95696-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UKZ1-1",
        "uniprot_id": "CNO11_HUMAN",
        "mass": 55215.0,
        "length": 510,
        "protein_name": "CCR4-NOT transcription complex subunit 11",
        "gene_name": "CNOT11",
        "organism": "Human",
        "refseq_name": "CCR4-NOT transcription complex subunit 11",
        "refseq_ac": "NP_060016",
        "gene_names_uniprotkb": "CNOT11; C2orf29; C40",
        "gene_names_refseq": "C2orf29; C40; CNOT11",
        "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 11",
        "protein_names_refseq": "CCR4-NOT transcription complex subunit 11; UPF0760 protein C2orf29",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55571);  (R-HSA-429947);  (R-HSA-6804115);  (R-HSA-9820841)",
        "pathway_count": 4,
        "publication_count": 96,
        "publication_id_list": "10497265;10637334;10882133;11237011;11283721;11814693;11889047;11896574;12897130;1355481;14583602;14749774;14968113;15475613;15713436;16140933;16141059;16160013;16284618;17052452;17146433;17245413;17595167;18337750;18625844;19239894;19276069;19415658;19558367;20352051;20531387;22252318;23232451;23236473;23303381;24129315;25418920;25480299;25505266;25576301;26154972;26728094;26992070;27846572;27862975;27920218;28063628;28228285;28832583;28834231;28904123;29242379;29351928;29557506;29632046;30315122;30410026;30429286;30833945;31154438;31530632;31844290;31848261;32157095;32265295;32350084;32357974;32387766;32502341;32502391;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33936100;34019948;34171305;34357683;34647228;34932366;35051231;35580925;36010968;36241641;39302247;40596516;40914422;8944033;9099687;9184226;9671765;9712883",
        "class_list": "",
        "function": "CNOT11 interacts with the first amino acids of CNOT1 and with CNOT10 and is required for the association of CNOT10 with the CCR4-NOT complex., [RefSeq, PubMed]; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Does not seem to be required for complex deadenylase function., [UniProtKB]; Human CNOT10 and CNOT11 form a complex that interacts with the CNOT1 N-terminal domain., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6P2M9;Q8N681",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030014 CCR4-NOT complex;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening",
        "synthesized_glycan_count": 0,
        "hit_score": 10.0,
        "record_id": "Q9UKZ1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BYG0-1",
        "uniprot_id": "B3GN5_HUMAN",
        "mass": 44053.0,
        "length": 378,
        "protein_name": "Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase",
        "gene_name": "B3GNT5",
        "organism": "Human",
        "refseq_name": "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase",
        "refseq_ac": "NP_114436",
        "gene_names_uniprotkb": "B3GNT5",
        "gene_names_refseq": "B3GN-T5; B3GNT5; beta3Gn-T5",
        "protein_names_uniprotkb": "Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; 2.4.1.206; BGnT-5; Beta-1,3-Gn-T5; Beta-1,3-N-acetylglucosaminyltransferase 5; Beta3Gn-T5; Lactotriaosylceramide synthase; Lc(3)Cer synthase; Lc3 synthase; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5",
        "protein_names_refseq": "BGnT-5; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5; beta 1,3 N-acetyglucosaminyltransferase Lc3 synthase; beta-1,3-Gn-T5; beta-1,3-N-acetylglucosaminyltransferase 5; beta-1,3-N-acetylglucosaminyltransferase bGnT-5; lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; lactotriaosylceramide synthase; lc(3)Cer synthase; lc3 synthase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84002);  (R-HSA-913709);  (R-HSA-9840309)",
        "pathway_count": 3,
        "publication_count": 70,
        "publication_id_list": "10330415;10430883;10601645;10748143;10753916;10993897;11018043;11042166;11237011;11283017;11304796;11384981;11821425;11956206;12222957;12668675;12815231;12855678;12888565;1329093;15486459;15560372;15620693;1601877;16934889;17113861;18483624;18537974;20547865;2118655;22183981;22411838;22735313;23290777;23746551;23882130;24498430;24643043;25576301;27846572;27893789;28834231;29242379;29802621;31530632;32387766;32677340;32983136;33141586;34982351;35051231;35580925;7655172;7876235;7890749;8643456;8830034;8910600;8920913;9030544;9125199;9199191;9295285;9394011;9417100;9435216;9582303;9822625;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "B3GNT5 is a novel marker correlated with stem-like phenotype and poor clinical outcome in human gliomas., [RefSeq, PubMed]; Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development., [UniProtKB, PubMed, PubMed]; Bone marrow samples of acute myeloid leukemia patients had 16-fold higher expression of B3GNT5 than those of healthy donors, [RefSeq, PubMed]; Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x, [RefSeq, PubMed]; This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 404,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DNS5;Q59FE3;Q7L9Z5;Q8WWP9",
        "ec_number_list": "2.4.1.-;2.4.1.147;2.4.1.149;2.4.1.206;2.4.1.146",
        "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0047256 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane",
        "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0009101 glycoprotein biosynthetic process;GO:0007417 central nervous system development;GO:0009247 glycolipid biosynthetic process",
        "synthesized_glycan_count": 545,
        "hit_score": 7.1,
        "record_id": "Q9BYG0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TDH9-1",
        "uniprot_id": "BL1S5_HUMAN",
        "mass": 21609.0,
        "length": 187,
        "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 5",
        "gene_name": "BLOC1S5",
        "organism": "Human",
        "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 5 isoform 2",
        "refseq_ac": "NP_001186251",
        "gene_names_uniprotkb": "BLOC1S5; MUTED",
        "gene_names_refseq": "BLOC1S5; BLOS5; HPS11; MUTED; MU",
        "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 5; BLOC-1 subunit 5; Protein Muted homolog",
        "protein_names_refseq": "BLOC-1 subunit 5; biogenesis of lysosomal organelles complex-1, subunit 5, muted; biogenesis of lysosome-related organelles complex 1 subunit 5 isoform 2; biogenesis of lysosome-related organelles complex 1 subunit 5; muted homolog; protein Muted homolog",
        "tax_id": 9606,
        "disease": "platelet storage pool deficiency (Disease Ontology:DOID:2223); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); Hermansky-Pudlak syndrome 11 (MONDO:MONDO:0030903)",
        "pathway": " (hsa:63915)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "11237011;11912185;12019270;12191018;17182842;22203680;23301498;23481700;24715725;25576301;26154972;26375851;27862975;28832583;28834231;29242379;29485866;29508533;29557506;29786170;30429286;31530632;31844290;31848261;32157095;32387766;32565547;32897882;32938616;33717175;33968037;34058075;34509645;34685610",
        "class_list": "",
        "function": "A Novel Likely Pathogenic Variant in the BLOC1S5 Gene Associated with Hermansky-Pudlak Syndrome Type 11 and an Overview of Human BLOC-1 Deficiencies. Review article Publication Status: Online-Only, [RefSeq, PubMed]; A novel BLOC1S5-related HPS-11 patient and zebrafish with bloc1s5 disruption., [RefSeq, PubMed]; BLOC1S5 pathogenic variants cause a new type of Hermansky-Pudlak syndrome., [RefSeq, PubMed]; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:32565547). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking., [UniProtKB, PubMed, PubMed]; This gene encodes a component of BLOC-1 (biogenesis of lysosome-related organelles complex 1). Components of this complex are involved in the biogenesis of organelles such as melanosomes and platelet-dense granules. A mouse model for Hermansky-Pudlak Syndrome is mutated in the murine version of this gene. Alternative splicing results in multiple transcript variants. Read-through transcription exists between this gene and the upstream EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) gene, as well as with the downstream TXNDC5 (thioredoxin domain containing 5) gene. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DVM2;Q0VDJ6;Q0VDJ7;Q5THS1;Q68D56;Q8N5F9;Q9NU16",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0030133 transport vesicle;GO:1904115 axon cytoplasm;GO:0031083 BLOC-1 complex;GO:1990742 microvesicle",
        "go_biological_process": "GO:0031175 neuron projection development;GO:0008089 anterograde axonal transport;GO:0032438 melanosome organization;GO:0035646 endosome to melanosome transport;GO:0048490 anterograde synaptic vesicle transport",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q8TDH9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86YC2-1",
        "uniprot_id": "PALB2_HUMAN",
        "mass": 131295.0,
        "length": 1186,
        "protein_name": "Partner and localizer of BRCA2",
        "gene_name": "PALB2",
        "organism": "Human",
        "refseq_name": "partner and localizer of BRCA2 isoform 1",
        "refseq_ac": "NP_078951",
        "gene_names_uniprotkb": "PALB2; FANCN",
        "gene_names_refseq": "BROVCA5; FANCN; PALB2; PNCA3",
        "protein_names_uniprotkb": "Partner and localizer of BRCA2",
        "protein_names_refseq": "mutant partner and localizer of BRCA2; partner and localizer of BRCA2 isoform 1",
        "tax_id": 9606,
        "disease": "female breast cancer (Disease Ontology:DOID:0050671); Fanconi anemia complementation group N (Disease Ontology:DOID:0111094); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); hereditary breast ovarian cancer syndrome (Disease Ontology:DOID:5683); pancreatic cancer, susceptibility to, 3 (MONDO:MONDO:0013236); breast-ovarian cancer, familial, susceptibility to, 5 (MONDO:MONDO:0957530)",
        "pathway": " (hsa:79728);  (R-HSA-5685942);  (R-HSA-5693537);  (R-HSA-5693554);  (R-HSA-5693568);  (R-HSA-5693579);  (R-HSA-8951664);  (R-HSA-9701192);  (R-HSA-9704331);  (R-HSA-9704646);  (R-HSA-9709603);  (R-HSA-9755511)",
        "pathway_count": 12,
        "publication_count": 269,
        "publication_id_list": "10535940;10597293;10801132;10811609;10856253;10878807;10973499;11006276;11069780;11237011;11259415;11292861;11292862;11454738;11459987;11585840;11733065;11751635;11961546;12101228;12186903;12198130;12504025;12504026;12526791;12538644;12609982;12682069;12686547;12700136;12721304;12759363;12816948;12912992;14517290;14527420;14585973;14688281;14690597;14716019;14757770;14764894;15282312;15302935;15361859;15367669;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15799966;15916957;15983046;16171779;16286508;16337601;16359182;16401342;16547496;16647857;16707496;16790436;16793542;16943200;16962933;17081101;17114795;17132228;17183367;17200668;17200671;17200672;17220875;17287723;17289582;17332328;17420451;17497243;17512459;17525332;17785452;17979524;17996710;17996711;18053174;18077418;18093314;18206966;18238777;18273910;18452278;18775313;18776931;18805092;18826954;18851830;18926707;18957201;18987736;19074197;19250909;19264984;19268590;19321346;19369211;19413330;19423707;19584259;19596236;19609323;19617556;19664994;19664995;19690332;19748355;19941829;20068231;20207730;20332121;20378532;20452972;20495340;20871615;20871616;20965415;21113654;21220506;21391649;21447816;21463634;21520333;21618343;21734707;21778237;21863050;21940857;22193777;22241545;22306028;22466964;22537386;22593209;22645308;22789539;22872865;22941656;22959436;23149936;23186163;23201271;23274085;23333871;23401859;23448497;23453757;23481700;23509288;23535662;23535663;23563313;23583660;23686288;23731732;23754376;23912815;23986495;24011591;24076221;24076655;24141787;24298019;24366543;24371268;24485656;24509834;24556926;24636985;24715725;24793695;24793696;24831703;25040165;25314029;25349211;25355947;25418920;25531226;25576301;25793262;25892735;25921531;26117325;26154972;26344709;26420486;26460955;26583321;26632597;26811146;26833090;26906416;26942676;27030794;27222660;27565346;27899578;27920218;28063628;28089683;28115426;28158555;28240985;28319063;28380357;28832583;28904123;29153394;29165669;29233872;29242379;29387807;29393594;29450944;29526543;29557506;29608566;29632046;30059200;30289697;30311374;30610225;31546975;31586400;31636395;31757951;31841383;31844290;32005965;32157095;32265295;32284348;32293500;32387766;32640524;32672401;32732220;32897882;33009401;33195396;33298915;33444648;33791708;33859744;33912179;33936100;33981976;35051231;35561310;36241641;37592023;38061684;38597967;38914840;9790970;9887101;9891082",
        "class_list": "",
        "function": "Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk. Erratum:[Nat Genet. 2023 Nov;55(11):2009. doi: 10.1038/s41588-023-01549-x. PMID: 37752376], [RefSeq, PubMed]; PALB2 colocalizes with BRCA2 in nuclear foci, promotes its localization and stability in key nuclear structures (e.g., chromatin and nuclear matrix), and enables its recombinational repair and checkpoint functions GeneRIF: FLJ21816 has been identified as a major binding protein of the breast cancer susceptibility protein BRCA2 and named 'PALB2'., [RefSeq, PubMed]; PALB2-mutated human mammary cells display a broad spectrum of morphological and functional abnormalities induced by increased TGFbeta signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Profiling of the genetic features of patients with breast, ovarian, colorectal and extracolonic cancers: Association to CHEK2 and PALB2 germline mutations., [RefSeq, PubMed]; Spectrum and characteristics of germline PALB2 pathogenic variants in 1556 early-onset breast cancer patients in China. Publication Status: Online-Only, [RefSeq, PubMed]; The results show that PALB2 is a breast cancer susceptibility gene and further demonstrate the close relationship of the Fanconi anemia-DNA repair pathway and breast cancer predisposition., [RefSeq, PubMed]; This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
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        "secondary_ac_list": "A6NIE1;Q8N7Y6;Q8ND31;Q9H6W1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination",
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    },
    {
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        "uniprot_id": "BSDC1_HUMAN",
        "mass": 47163.0,
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        "protein_name": "BSD domain-containing protein 1",
        "gene_name": "BSDC1",
        "organism": "Human",
        "refseq_name": "BSD domain-containing protein 1 isoform a",
        "refseq_ac": "NP_001137360",
        "gene_names_uniprotkb": "BSDC1; PRO5781",
        "gene_names_refseq": "BSDC1",
        "protein_names_uniprotkb": "BSD domain-containing protein 1",
        "protein_names_refseq": "BSD domain-containing protein 1 isoform a; BSD domain-containing protein 1",
        "tax_id": 9606,
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        "pathway": " (hsa:55108)",
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        "secondary_ac_list": "B4DMS7;B4DTI7;B4DTP7;B4E2X8;Q49AT8;Q68DY6;Q6IAA3;Q6MZK1;Q6UXS1;Q9HAL9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus",
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    {
        "uniprot_canonical_ac": "Q96T37-1",
        "uniprot_id": "RBM15_HUMAN",
        "mass": 107189.0,
        "length": 977,
        "protein_name": "RNA-binding protein 15",
        "gene_name": "RBM15",
        "organism": "Human",
        "refseq_name": "RNA-binding protein 15 isoform 2",
        "refseq_ac": "NP_001188474",
        "gene_names_uniprotkb": "RBM15; OTT1; OTT",
        "gene_names_refseq": "OTT1; OTT; RBM15",
        "protein_names_uniprotkb": "RNA-binding protein 15; One-twenty two protein 1; RNA-binding motif protein 15",
        "protein_names_refseq": "RNA-binding protein 15 isoform 2; one twenty two protein; one twenty-two; one-twenty two protein 1; putative RNA-binding protein 15",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64783)",
        "pathway_count": 1,
        "publication_count": 105,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11344311;11431691;15302935;15849773;16129689;16964243;17001072;17081983;17287340;17322306;17525332;17924679;18212344;18220336;18452278;18491316;18669648;18691976;18707149;18767875;19413330;19415658;19562805;19586903;19608861;19651622;19664995;19690332;19691289;19786495;20058876;20068230;20068231;20166139;20230923;21406692;22424782;22544926;22927943;23186163;23481700;24100041;24275569;24715725;25367160;25418920;25576301;25645385;26575292;26811146;26992070;27602518;27846572;27920218;28063628;28228285;28832583;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30429286;30620550;30833945;31154438;31217245;31844290;31848261;32157095;32161166;32265295;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33717175;33912179;33936100;33968037;34019948;34171305;34509645;35051231;35580925;36284347;37217939;37594126;38825643;38842201;39118157;39206850;40596516;40914422",
        "class_list": "",
        "function": "Fusion with MKL1 protein in acute myeloid leukemi., [RefSeq, PubMed]; Identification of RBM15 as a prognostic biomarker in prostate cancer involving the regulation of prognostic m6A-related lncRNAs. Publication Status: Online-Only, [RefSeq, PubMed]; Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]., [RefSeq]; RBM15 Promotes High Glucose-Induced Lens Epithelial Cell Injury by Inducing PRNP N6-Methyladenine Modification During Diabetic Cataract., [RefSeq, PubMed]; RBM15-Mediated N6-Methyl Adenosine (m6A) Modification of EZH2 Drives the Epithelial-Mesenchymal Transition of Cervical Cancer., [RefSeq, PubMed]; RBM15-mediating MDR1 mRNA m[6]A methylation regulated by the TGF-beta signaling pathway in paclitaxel-resistant ovarian cancer., [RefSeq, PubMed]; RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The m[6]A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
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        "total_n_glycosites": 1,
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        "reported_phosphosites": 41,
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        "secondary_ac_list": "A1A693;Q3ZB86;Q4V760;Q5D058;Q5T613;Q86VW9;Q96PE4;Q96SC5;Q96SC6;Q96SC9;Q96SD0;Q96T38;Q9BRA5;Q9H6R8;Q9H9Y0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding",
        "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0031965 nuclear membrane",
        "go_biological_process": "GO:0045652 regulation of megakaryocyte differentiation;GO:0009048 dosage compensation by inactivation of X chromosome;GO:0001510 RNA methylation;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0038163 thrombopoietin-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 11.2,
        "record_id": "Q96T37-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NRQ5-1",
        "uniprot_id": "SMCO4_HUMAN",
        "mass": 6738.0,
        "length": 59,
        "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 4",
        "gene_name": "SMCO4",
        "organism": "Human",
        "refseq_name": "single-pass membrane and coiled-coil domain-containing protein 4",
        "refseq_ac": "NP_064564",
        "gene_names_uniprotkb": "SMCO4; C11orf75; FN5",
        "gene_names_refseq": "C11orf75; FN5; SMCO4",
        "protein_names_uniprotkb": "Single-pass membrane and coiled-coil domain-containing protein 4; Protein FN5",
        "protein_names_refseq": "UPF0443 protein C11orf75; single-pass membrane and coiled-coil domain-containing protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56935)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "10863097;11237011;27452731;28218747;28228285;28832583;29242379;29557506;29786170;30315122;31092671;31154438;31611695;31844290;32357974;34357683;34561969;35580925;36010968;36241641;36284347",
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        "go_cellular_component": "GO:0016020 membrane",
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        "hit_score": 2.2,
        "record_id": "Q9NRQ5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75815-1",
        "uniprot_id": "BCAR3_HUMAN",
        "mass": 92566.0,
        "length": 825,
        "protein_name": "Breast cancer anti-estrogen resistance protein 3",
        "gene_name": "BCAR3",
        "organism": "Human",
        "refseq_name": "breast cancer anti-estrogen resistance protein 3 isoform 1",
        "refseq_ac": "NP_001248337",
        "gene_names_uniprotkb": "BCAR3; NSP2; PRO308; SH2D3B",
        "gene_names_refseq": "AND-34; BCAR3; MIG7; NSP2; SH2D3B",
        "protein_names_uniprotkb": "Breast cancer anti-estrogen resistance protein 3; Novel SH2-containing protein 2; SH2 domain-containing protein 3B",
        "protein_names_refseq": "BCAR3, NSP family adaptor protein; SH2 domain-containing protein 3B; breast cancer anti-estrogen resistance protein 3 isoform 1; breast cancer anti-estrogen resistance protein 3; breast cancer antiestrogen resistance 3 protein; dJ1033H22.2 (breast cancer anti-estrogen resistance 3); epididymis secretory sperm binding protein; mig-7; migration inducting gene-7; novel SH2-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8412)",
        "pathway_count": 1,
        "publication_count": 78,
        "publication_id_list": "10.1101/2023.09.13.557529;10187783;12975309;16964243;17016520;17081983;17389395;17924679;18669648;18722344;19086031;19103205;19651622;20068231;22081014;22801373;23186163;23481700;24129315;24216110;24366607;25418920;25576301;25645385;25892735;26375851;26929215;27846572;27862975;27920218;28218747;28832583;28904123;29242379;29437277;29557506;29632711;29786170;30315122;30410026;30429286;30779550;30833945;31154438;31222486;31530632;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33592498;33691108;33912179;33968037;34169835;34171305;34185709;34932366;35031902;35051231;35318648;35413271;35561310;35580925;36010968;36284347;37938771;38063095;9582273",
        "class_list": "",
        "function": "A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics. Publication Status: Online-Only, [RefSeq, PubMed]; Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]., [RefSeq]; CircBCAR3 sponges miR-27a-3p and mediates ferroptosis in human B-prolymphocytic leukaemia cells via SLC7A11. Publication Status: Online-Only, [RefSeq, PubMed]; Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3 expression in patients with Luminal A and B breast cancer subtypes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 15,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DT43;Q5TEW3;Q6UW40;Q9BR50",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0019900 kinase binding;GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005925 focal adhesion;GO:0016020 membrane",
        "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0043547 positive regulation of GTPase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 8.1,
        "record_id": "O75815-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43353-1",
        "uniprot_id": "RIPK2_HUMAN",
        "mass": 61195.0,
        "length": 540,
        "protein_name": "Receptor-interacting serine/threonine-protein kinase 2",
        "gene_name": "RIPK2",
        "organism": "Human",
        "refseq_name": "receptor-interacting serine/threonine-protein kinase 2 isoform 1",
        "refseq_ac": "NP_003812",
        "gene_names_uniprotkb": "RIPK2; CARDIAK; PRO34092; RICK; RIP2",
        "gene_names_refseq": "CARD3; CARDIAK; CCK; GIG30; RICK; RIP2; RIPK2",
        "protein_names_uniprotkb": "Receptor-interacting serine/threonine-protein kinase 2; 2.7.10.2; 2.7.11.1; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; RIP-2; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; Tyrosine-protein kinase RIPK2",
        "protein_names_refseq": "CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; RIP-2; growth-inhibiting gene 30; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; receptor-interacting protein 2; receptor-interacting serine/threonine-protein kinase 2 isoform 1; receptor-interacting serine/threonine-protein kinase 2; tyrosine-protein kinase RIPK2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8767);  (R-HSA-168638);  (R-HSA-202424);  (R-HSA-209543);  (R-HSA-445989);  (R-HSA-450302);  (R-HSA-450321);  (R-HSA-5689896);  (R-HSA-9020702);  (R-HSA-9705671)",
        "pathway_count": 10,
        "publication_count": 263,
        "publication_id_list": "10075690;10224040;10329646;10385526;10514433;10698680;10702308;10716940;10723127;10747026;10854325;10882101;10918611;11087742;11094434;11237011;11244088;11358993;11460167;11463333;11487608;11884229;11960013;12019269;12171911;12473184;12496252;12514169;12527755;12538665;12660731;12692549;12759408;12791687;12791997;12796777;12860405;12917691;12975309;14514672;14625308;14633987;14638696;14661020;15044951;15122200;15125833;15145317;15208624;15258597;15327770;15334086;15371334;15465037;15541657;15620648;15837794;15917247;16056267;16186825;16356853;16356855;16612002;16824733;16978534;17047224;17054981;17072321;17135271;17141195;17303577;17344846;17355968;17363905;17468049;17496917;17507369;17525332;17548359;17562858;17675297;17728323;17890055;17997719;18070982;18079694;18180283;1828071;1833184;18438411;18462684;18669648;18691976;18775659;19264966;19369195;19383985;19464198;19464428;19535145;19592251;19818707;19901323;19903815;19996094;20058876;20068231;20300203;20553488;21123652;2139180;2147937;21887730;21931591;22124327;22520462;22607974;22672233;22941947;23186163;23301498;23806334;23827681;24610782;24658576;24715725;25576301;25904330;26154972;26280536;26320862;26646181;26992070;27466718;27701768;27812135;27830463;28218747;28228285;28436939;28510447;28545134;28656966;28832583;28855257;28904123;29242379;29452636;2946959;29557506;29789417;29874851;30026309;30279485;30315122;30410026;30429286;30478312;31092671;31350258;31844290;31850239;32350084;32353859;32357974;32387766;32428392;32589897;32726803;32728199;32938616;32953130;32979938;32983136;33024073;33060197;33097660;33110251;33141586;33298915;33349665;33360543;33372174;33372854;33396605;33440148;33479219;33495715;33514628;33567255;33592498;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33936100;33963333;33968037;33981976;33989516;33990585;34021074;34054808;34084167;34087483;34110168;34166398;34239064;34290717;34341353;34375313;34400613;34405274;34439781;34452305;34471099;34502139;34509645;34561969;34597346;35051231;35102342;35561310;35643212;36010968;36221902;36284347;37051252;37488967;37914353;38227684;7479848;7628694;8327496;8332913;8533096;8550590;8599092;8601309;8622669;8837778;9252186;9346484;9362451;9371760;9430229;9430721;9575168;9575181;9642260;9687533;9705938;9744859;9768359;9859996;9865693;9915784;9990852;9990853",
        "class_list": "",
        "function": "Mechanism of Human Cytomegalovirus-Induced Epithelial-Mesenchymal Transition in Glioma Cells via the Upregulation of RIP2 Expression., [RefSeq, PubMed]; NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2- and NF-kB-independent manner., [RefSeq, PubMed]; Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (PubMed:14638696, PubMed:17054981, PubMed:21123652, PubMed:28656966, PubMed:9575181, PubMed:9642260). Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments (PubMed:17054981, PubMed:17562858, PubMed:21123652, PubMed:22607974, PubMed:28656966, PubMed:29452636, PubMed:30026309). Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors (PubMed:22607974, PubMed:28545134, PubMed:29452636, PubMed:30026309, PubMed:30279485, PubMed:30478312). 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process (PubMed:17562858, PubMed:22607974, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB (PubMed:18079694). In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18079694). The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways (PubMed:29452636, PubMed:30026309). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (PubMed:21887730). Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2., [RefSeq, PubMed]; This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 40,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z748;Q6UWF0",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.10.1;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.2.-;3.4.19.12;2.3.1.48;2.3.1.-;2.7.1.32;2.7.1.82;2.7.10.4;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.23;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;2.3.2.26;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0032727 positive regulation of interferon-alpha production;GO:0006954 inflammatory response;GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 26.6,
        "record_id": "O43353-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99496-1",
        "uniprot_id": "RING2_HUMAN",
        "mass": 37655.0,
        "length": 336,
        "protein_name": "E3 ubiquitin-protein ligase RING2",
        "gene_name": "RNF2",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase RING2",
        "refseq_ac": "NP_009143",
        "gene_names_uniprotkb": "RNF2; BAP1; DING; HIPI3; RING1B",
        "gene_names_refseq": "BAP-1; BAP1; DING; HIPI3; LUSYAM; RING1B; RING2; RNF2",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RING2; 2.3.2.27; HIP2-interacting protein 3; Huntingtin-interacting protein 2-interacting protein 3; Protein DinG; RING finger protein 1B; RING finger protein 2; RING finger protein BAP-1; RING-type E3 ubiquitin transferase RING2; RING1b",
        "protein_names_refseq": "E3 ubiquitin-protein ligase RING2; HIP2-interacting protein 3; RING finger protein 1B; RING finger protein BAP-1; RING-type E3 ubiquitin transferase RING2; huntingtin-interacting protein 2-interacting protein 3; protein DinG",
        "tax_id": 9606,
        "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); developmental disorder of mental health (Disease Ontology:DOID:0060037); Luo-Schoch-Yamamoto syndrome (Disease Ontology:DOID:0070416); spina bifida (Disease Ontology:DOID:0080016); cancer (Disease Ontology:DOID:162); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)",
        "pathway": " (hsa:6045);  (R-HSA-2559580);  (R-HSA-3108214);  (R-HSA-3899300);  (R-HSA-4551638);  (R-HSA-4570464);  (R-HSA-4655427);  (R-HSA-8939243);  (R-HSA-8943724);  (R-HSA-8953750);  (R-HSA-9976102)",
        "pathway_count": 11,
        "publication_count": 269,
        "publication_id_list": "10.1101/2023.09.13.557529;10347217;10574707;10722742;10772813;10871633;11171983;11237011;11378386;11477070;11513855;11545734;11564866;11735126;11781575;11792325;11842083;11865070;11889051;11959846;11960997;12004135;12032081;12134156;12150977;12167701;12189133;12193592;12196509;12421820;12435631;12529333;12679040;12718889;12808055;12909625;13130464;14507994;14532106;14578449;14701874;15014447;15082759;15161980;15175327;15199155;15287722;15355988;15386022;15536069;15563468;15592428;15608651;15766567;15823533;15829507;15866172;15940266;15958389;15959518;15960975;15976810;16030353;16098147;16186825;16337592;16359901;16418168;16436515;16478998;16608850;16626738;16676006;16688858;16702404;16714294;16757475;16810316;16826196;16917507;16943429;17001316;17018294;17079232;17081983;17081986;17210787;17254968;17255097;17298944;17332741;17344414;17369852;17395714;17535915;17600109;17693435;17765224;17803295;17825402;17873065;17875933;17942393;17974977;18082607;18172008;18211901;18339323;18365017;18391013;18408014;18487508;18488044;18562691;18625722;18628979;18691969;18695000;18708356;18762900;18793328;19007248;19240082;19287951;19413330;19440552;19450230;19451217;19451218;19462008;19528227;19596686;19615980;19622798;19636380;19691289;19706679;19779455;19791798;19884659;19956565;19995069;20016594;20016603;20068231;20098713;20176810;20190268;20233713;20305658;20351170;20417598;20506188;20516213;20676127;20696397;20705237;20797632;20797634;21098080;21147198;21284855;21289308;21338522;21527249;21550342;21596310;21647297;21772249;21986495;22020331;22128185;22325351;22325352;22336108;22402492;22467880;22493095;22508508;22635276;22661230;22683641;22713328;22751501;22825850;23092970;23186163;23287862;23301498;23404503;23673342;23750026;23871147;23954429;24027577;24068740;24369422;24627085;24718924;24782567;25114211;25218447;25355358;25391492;25519132;25704882;25728608;25800734;26100231;26151332;26687479;26758079;26910647;27068747;28720707;28832583;29242379;29393594;29786170;30779550;31154438;31844290;32157095;32897882;32938616;33214551;33298915;33864376;33912179;33968037;34019948;35051231;35580925;36932026;37037816;37806249;38878927;40596516;7535770;7588633;7623816;7816143;7859739;8001816;8078588;8259215;8319905;8622669;8622688;8626550;8741839;8774846;8846784;8974401;9030721;9162092;9195981;9412458;9452416;9501179;9529249;9564042;9628874;9689056;9704927;9756909;9768359;9824166;9885291",
        "class_list": "",
        "function": "Citrullinating enzyme PADI4 and transcriptional repressor RING1B bind in cancer cells., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:21772249, PubMed:25355358, PubMed:25519132, PubMed:26151332, PubMed:33864376). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity). Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; M phase-specific interaction between SBDS and RNF2 at the mitotic spindles regulates mitotic progression., [RefSeq, PubMed]; N-Terminally arginylated ubiquitin is attached to histone H2A by RING1B E3 ligase in human cells., [RefSeq, PubMed]; Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008]., [RefSeq]; RNF2 inhibits E-Cadherin transcription to promote hepatocellular carcinoma metastasis via inducing histone mono-ubiquitination. Publication Status: Online-Only, [RefSeq, PubMed]; The human PcG protein dinG interacts with CP2, a mammalian member of the grainyhead-like family of transcription factors, in vitro and in vivo. The functional consequence of this interaction is repression of CP2-dependent transcription., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 2,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 6,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBS7;B3KRH1;Q5TEN1;Q5TEN2",
        "ec_number_list": "2.3.2.-;2.7.11.1;1.14.11.68;3.5.1.-;3.5.1.98;1.14.11.-;1.14.11.65;1.14.99.66;2.1.1.367;2.1.1.-;2.1.1.364;2.3.2.27;2.3.1.48;2.3.1.-;3.6.4.-;1.1.1.-;2.7.11.24;2.1.1.356;2.3.1.57;3.5.1.48;3.5.1.62;2.1.1.37",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0071535 RING-like zinc finger domain binding;GO:0140862 histone H2AK119 ubiquitin ligase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 27.6,
        "record_id": "Q99496-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9GZL7-1",
        "uniprot_id": "WDR12_HUMAN",
        "mass": 47708.0,
        "length": 423,
        "protein_name": "Ribosome biogenesis protein WDR12",
        "gene_name": "WDR12",
        "organism": "Human",
        "refseq_name": "ribosome biogenesis protein WDR12 isoform 1",
        "refseq_ac": "NP_060726",
        "gene_names_uniprotkb": "WDR12",
        "gene_names_refseq": "WDR12; YTM1",
        "protein_names_uniprotkb": "Ribosome biogenesis protein WDR12; WD repeat-containing protein 12",
        "protein_names_refseq": "WD repeat-containing protein 12; ribosome biogenesis protein WDR12 isoform 1; ribosome biogenesis protein WDR12",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55759);  (R-HSA-6791226)",
        "pathway_count": 2,
        "publication_count": 112,
        "publication_id_list": "11922599;12068309;12150911;12429849;16037817;16043514;16738141;17189298;17353269;17412707;18065403;18438418;19106111;19332556;19564402;19801658;20038530;20056613;20531386;20798176;20805244;20819938;21036871;21063389;21097556;22072790;22190735;22195017;22645359;22916032;23186163;23439679;23481700;23482395;2388630;24424021;24550520;24714562;24715725;25114211;25525153;25576301;25645385;25969445;26024233;26154972;26237581;26601951;26728094;26992070;27397612;27846572;27862975;27920218;28063628;28218747;28228285;28352266;28510447;28649982;28832583;28834231;28904123;29242379;29437277;29493099;29508533;29557506;29632046;29786170;30315122;30410026;30429286;30484775;30524438;30779550;30833945;31154438;31844290;31848261;31998317;32157095;32161166;32265295;32357974;32488085;32897882;32938616;32983136;33141586;33298915;33592498;33633747;33968037;33981976;34087483;34171305;34229054;34725712;34932366;35051231;35318648;35561310;35580925;36010968;36241641;36284347;37217939;37938771;38795544;40914422;9482744",
        "class_list": "",
        "function": "CircMIRIAF aggravates myocardial ischemia-reperfusion injury via targeting miR-544/WDR12 axis., [RefSeq, PubMed]; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, PubMed, HAMAP, PubMed]; This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008]., [RefSeq]; WDR12 triggers accumulation of p53 in a p19ARF-independent manner in proliferating cells but not in quiescent cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KPA9;Q96HU0;Q9NV80;Q9NYI8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0070545 PeBoW complex",
        "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0051726 regulation of cell cycle;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "Q9GZL7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y4A5-1",
        "uniprot_id": "TRRAP_HUMAN",
        "mass": 437600.0,
        "length": 3859,
        "protein_name": "Transformation/transcription domain-associated protein",
        "gene_name": "TRRAP",
        "organism": "Human",
        "refseq_name": "transformation/transcription domain-associated protein isoform 1",
        "refseq_ac": "NP_001231509",
        "gene_names_uniprotkb": "TRRAP; PAF400",
        "gene_names_refseq": "DEDDFA; DFNA75; PAF350/400; PAF400; STAF40; TR-AP; TRRAP; Tra1",
        "protein_names_uniprotkb": "Transformation/transcription domain-associated protein; 350/400 kDa PCAF-associated factor; PAF350/400; STAF40; Tra1 homolog",
        "protein_names_refseq": "350/400 kDa PCAF-associated factor; tra1 homolog; transformation/transcription domain-associated protein isoform 1",
        "tax_id": 9606,
        "disease": "autosomal dominant nonsyndromic deafness (Disease Ontology:DOID:0050564); autosomal dominant nonsyndromic deafness 75 (Disease Ontology:DOID:0112166); developmental delay with or without dysmorphic facies and autism (MONDO:MONDO:0032760)",
        "pathway": " (hsa:8295);  (R-HSA-201722);  (R-HSA-3214847);  (R-HSA-5689880)",
        "pathway_count": 4,
        "publication_count": 274,
        "publication_id_list": "10.1101/2023.09.13.557529;10080941;10373431;10444327;10485845;10611234;10769018;10775268;10786633;10821277;10831834;10966108;10982817;11050151;11080158;11136974;11237011;11418595;11445536;11532957;11564863;11566882;11713476;11839798;11923872;11934263;11955446;11973335;11988739;12138177;12163411;12660246;12743606;12917689;12917691;14661020;14695187;14966270;15053880;15060161;15121853;15294866;15313887;15768032;15829968;15916963;16005293;16169192;16214042;16387653;16510874;16630820;16756492;16901786;16964248;17052462;17074750;17290220;17344846;17425782;17428831;17443180;17458864;17694078;17873522;17967892;17980597;17981138;18160704;18172164;18206972;18347063;18381289;18404694;18467330;18498752;18623064;18632802;18636086;18669648;18691976;19015242;19135894;19148484;19187765;19188362;19363159;19398555;19424180;19460168;19487454;19493659;19571879;19608861;19838211;19874889;19910467;20018852;20085741;20096447;20112406;20228808;20368735;20427287;20501646;21239494;21362556;21499247;21571647;21596315;21654818;21659512;21726809;21849505;21962518;22029577;22085928;22128162;22186018;22190459;22216260;22223895;22424782;22617422;22869377;22898188;22982193;23159851;23186163;23395819;23481700;23486064;23783831;23824326;23825189;24056413;24260525;24366607;24463511;24493797;24714562;24715725;24896179;25197364;25305019;25418920;25469497;25576301;25578727;25645385;25880248;25892735;26154972;26375851;26728094;26758079;26768311;26811146;26929215;26992070;27397612;27543614;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28446606;28514659;28649982;28832583;28834231;28855257;28904123;29242379;29371260;29393594;29437277;29493099;29508533;29557506;29605689;29632046;29632711;29769354;29786170;29789417;30315122;30379171;30410026;30424743;30429286;30484775;30524438;30779550;30827496;30833945;31154438;31217245;31222486;31231791;31364055;31530632;31575892;31844290;31848261;31937595;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33091337;33123756;33141586;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33836029;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34405274;34509645;34561969;34811519;34830324;34932366;35051231;35151693;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37938771;40307207;40596516;7578059;8756721;8757136;8955148;9118222;9427644;9488439;9490669;9558366;9708738;9751710;9819412;9843967;9880483;9885574",
        "class_list": "",
        "function": "Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Interaction of transcription factor FoxO3 with histone acetyltransferase complex subunit TRRAP modulates gene expression and apoptosis., [RefSeq, PubMed]; Knockdown of the adaptor protein TRRAP significantly increased differentiation of cultured brain tumor-initiating cells, sensitized the cells to apoptotic stimuli, and negatively affected cell cycle progression., [RefSeq, PubMed]; Several function of TRRAP during cellular process like: DNA repair, cell cycle, transcription etc... Review article, [RefSeq, PubMed]; This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 113,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 3,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D265;O75218;Q9Y631;Q9Y6H4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003712 transcription coregulator activity",
        "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0042981 regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 28.6,
        "record_id": "Q9Y4A5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9C0K0-1",
        "uniprot_id": "BC11B_HUMAN",
        "mass": 95519.0,
        "length": 894,
        "protein_name": "B-cell lymphoma/leukemia 11B",
        "gene_name": "BCL11B",
        "organism": "Human",
        "refseq_name": "B-cell lymphoma/leukemia 11B isoform 3",
        "refseq_ac": "NP_001269166",
        "gene_names_uniprotkb": "BCL11B; CTIP2; RIT1",
        "gene_names_refseq": "ATL1-alpha; ATL1-beta; ATL1-delta; ATL1-gamma; ATL1; BCL11B; CTIP-2; CTIP2; IDDFSTA; IMD49; RIT1; SMARCM2; ZNF856B; hRIT1-alpha",
        "protein_names_uniprotkb": "B-cell lymphoma/leukemia 11B; B-cell CLL/lymphoma 11B; BCL-11B; COUP-TF-interacting protein 2; Radiation-induced tumor suppressor gene 1 protein; hRit1",
        "protein_names_refseq": "B cell CLL/lymphoma 11B; B-cell CLL/lymphoma 11B (zinc finger protein); B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion protein; B-cell lymphoma/leukaemia 11B; B-cell lymphoma/leukemia 11B isoform 3; B-cell lymphoma/leukemia 11B; BAF chromatin remodeling complex subunit BCL11B; BCL-11B; BCL11B, BAF complex component; BCL11B/TRDC fusion; COUP-TF-interacting protein 2; radiation-induced tumor suppressor gene 1 protein; zinc finger protein hRit1 alpha",
        "tax_id": 9606,
        "disease": "specific developmental disorder (Disease Ontology:DOID:0060038); immunodeficiency 49 (Disease Ontology:DOID:0111979); neurodegenerative disease (Disease Ontology:DOID:1289); type 2 diabetes mellitus (Disease Ontology:DOID:9352); intellectual developmental disorder with speech delay, dysmorphic facies, and t-cell abnormalities (MONDO:MONDO:0060763)",
        "pathway": " (hsa:64919);  (R-HSA-9933946);  (R-HSA-9934037)",
        "pathway_count": 3,
        "publication_count": 42,
        "publication_id_list": "11237011;11719382;12368262;12565905;16809611;16959974;17640523;19608861;19690332;20058876;21220648;23644491;23785148;24275569;25755297;26601204;27862975;27959755;28228285;28832583;29242379;29393594;29493099;29557506;29985992;30315122;30833945;31154438;31844290;32938616;32983136;33968037;34171305;35051231;35132862;35580925;37737560;37956270;37986346;38495886;38829888;40307207",
        "class_list": "",
        "function": "A Bcl11b[N797K] variant isolated from an immunodeficient patient inhibits early thymocyte development in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Association between BCL11B gene polymorphisms and age-related hearing loss in the elderly: A case-control study in Qingdao, China. Publication Status: Online-Only, [RefSeq, PubMed]; BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells., [RefSeq, PubMed]; Differential expression of BCL11b and CDKN2A in CD30-positive peripheral T cell lymphoma: Retrospective study., [RefSeq, PubMed]; Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; The function of BCL11B in base excision repair contributes to its dual role as an oncogene and a haplo-insufficient tumor suppressor gene., [RefSeq, PubMed]; This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 23,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9H162",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0043005 neuron projection",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035701 hematopoietic stem cell migration;GO:0097535 lymphoid lineage cell migration into thymus;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q9C0K0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H4M3-1",
        "uniprot_id": "FBX44_HUMAN",
        "mass": 29747.0,
        "length": 255,
        "protein_name": "F-box only protein 44",
        "gene_name": "FBXO44",
        "organism": "Human",
        "refseq_name": "F-box only protein 44 isoform 1",
        "refseq_ac": "NP_001014765",
        "gene_names_uniprotkb": "FBXO44; FBG3; FBX30; FBX44; FBX6A; FBXO6A",
        "gene_names_refseq": "FBG3; FBX30; FBX6A; FBXO44; Fbx44; Fbxo6a",
        "protein_names_uniprotkb": "F-box only protein 44; F-box protein FBX30; F-box/G-domain protein 3",
        "protein_names_refseq": "F-box gene 3; F-box only protein 44 isoform 1; F-box only protein 44; F-box protein FBX30; F-box/G-domain protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:93611);  (R-HSA-8951664);  (R-HSA-983168)",
        "pathway_count": 3,
        "publication_count": 143,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11062501;11069780;11237011;11259415;11292861;11292862;11350924;11454738;11585840;11733065;11961546;12101228;12186903;12383498;12504025;12504026;12526791;12538644;12609982;12646216;12682069;12759363;12816948;14690597;14734113;14757770;15224091;15224092;15282312;15361859;15367669;15537541;15571818;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16595681;16647857;16707496;16790436;16849449;16943200;16954532;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18203720;18206966;18662542;18775313;18776931;18805092;18826954;18851830;18926707;19028597;19250909;19321346;19352404;19452197;19489725;19617556;19748355;19851334;19874575;19940261;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;2261476;22959436;23086937;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24366543;24636985;24715725;24793695;24793696;25314029;25349211;25355947;25531226;25576301;25970626;26344709;26375851;26460955;26632597;26906416;27030794;27222660;27565346;28115426;28832583;29153394;29493099;30610225;32005965;32284348;33008920;33357448;33444648;33968037;36241641;37969738;9380723;9668046;9790970;9887101;9891082",
        "class_list": "glycogene",
        "function": "FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells., [RefSeq, PubMed]; N-Terminal Targeting of Regulator of G Protein Signaling Protein 2 for F-Box Only Protein 44-Mediated Proteasomal Degradation., [RefSeq, PubMed]; Substrate-recognition component of two distinct E3 ligase complexes, the SKP1-CUL1-FBXO44 complex and the CUL4B-DDB1-FBXO44 complex (PubMed:18203720, PubMed:25970626). The complex SCF(FBXO44) complex ubiquitinates and mediates BRCA1 degradation (PubMed:23086937). In association with cullin 4B/CUL4B and DDB1, mediates the ubiquitination of RGS2 leading to its degradation (PubMed:25970626). Additionally, regulates the pregnane X receptor/NR1I2 protein level by ubiquitination and degradation (PubMed:37969738)., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 341,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KNZ2;B7Z743;Q5TGX2;Q5TGX4;Q5TGX5;Q68DJ9;Q8WWY2",
        "ec_number_list": "",
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0036503 ERAD pathway;GO:0006516 glycoprotein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 14.4,
        "record_id": "Q9H4M3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NVV4-1",
        "uniprot_id": "PAPD1_HUMAN",
        "mass": 66172.0,
        "length": 582,
        "protein_name": "Poly(A) RNA polymerase, mitochondrial",
        "gene_name": "MTPAP",
        "organism": "Human",
        "refseq_name": "poly(A) RNA polymerase, mitochondrial precursor",
        "refseq_ac": "NP_060579",
        "gene_names_uniprotkb": "MTPAP; PAPD1",
        "gene_names_refseq": "MTPAP; PAPD1; SPAX4; TENT6",
        "protein_names_uniprotkb": "Poly(A) RNA polymerase, mitochondrial; 2.7.7.19; PAP-associated domain-containing protein 1; PAP; Polynucleotide adenylyltransferase; TUTase 1; Terminal uridylyltransferase 1; mtPAP",
        "protein_names_refseq": "PAP-associated domain-containing protein 1; TUTase 1; poly(A) RNA polymerase, mitochondrial precursor; polynucleotide adenylyltransferase; terminal uridylyltransferase 1",
        "tax_id": 9606,
        "disease": "spastic ataxia 4 (Disease Ontology:DOID:0050943)",
        "pathway": " (hsa:55149);  (R-HSA-9937008)",
        "pathway_count": 2,
        "publication_count": 46,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15547249;15769737;16385451;16533400;18083837;18172165;19608861;19691289;20970105;21292163;23481700;25008111;25505266;25880248;25892735;26992070;27846572;27974379;28228285;28832583;28834231;28904123;29107537;29242379;29493099;29557506;29769354;30315122;31477916;31844290;31848261;32157095;32357974;32387766;32938616;32983136;33141586;33592498;33981976;34561969;35051231;36241641;36284347;38310689",
        "class_list": "",
        "function": "Cloning of a human nuclear-encoded mitochondrial poly(A) polymerase (hmtPAP)that has a role in mitochondrial RNA processing. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011]., [RefSeq]; USP4 regulates TUT1 ubiquitination status in concert with SART3., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DRX0;Q659E3;Q6P7E5;Q9HA74",
        "ec_number_list": "2.7.7.19;2.7.7.-;2.7.7.52",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0000965 mitochondrial RNA 3'-end processing;GO:0097222 mitochondrial mRNA polyadenylation;GO:0071044 histone mRNA catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q9NVV4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UBW5-1",
        "uniprot_id": "BIN2_HUMAN",
        "mass": 61874.0,
        "length": 565,
        "protein_name": "Bridging integrator 2",
        "gene_name": "BIN2",
        "organism": "Human",
        "refseq_name": "bridging integrator 2 isoform 2",
        "refseq_ac": "NP_001276936",
        "gene_names_uniprotkb": "BIN2; BRAP1",
        "gene_names_refseq": "BIN2; BRAP-1",
        "protein_names_uniprotkb": "Bridging integrator 2; Breast cancer-associated protein 1",
        "protein_names_refseq": "breast cancer associated protein BRAP1; breast cancer-associated protein 1; bridging integrator 2 isoform 2",
        "tax_id": 9606,
        "disease": "centronuclear myopathy 2 (Disease Ontology:DOID:0111220)",
        "pathway": " (hsa:51411);  (R-HSA-6798695);  (R-HSA-9673768)",
        "pathway_count": 3,
        "publication_count": 47,
        "publication_id_list": "10812249;10903846;11237011;16690743;19367720;19690332;20164854;20889717;23285027;23481700;23650620;24275569;24715725;26154972;26992070;27170215;28010895;28228285;28832583;28904123;29242379;29393594;29493099;29557506;29632046;29632711;30315122;30410026;31154438;31844290;31848261;32357974;32387766;32983136;33298915;33592498;33912179;34509645;34561969;35051231;35154160;35580925;36284347;37118339;40914422;8692836;8962143",
        "class_list": "",
        "function": "Bin2 is a BAR domain adapter protein structurally related but functionally distinct from family members Bin1 and amphiphysin., [RefSeq, PubMed]; Bin2 is a membrane-sculpting protein that influences podosome formation, motility and phagocytosis in leucocytes. Erratum:[PLoS One. 2013;8(8). doi:10.1371/annotation/3bdc487b-5e25-4cd7-a354-b2952eec943d], [RefSeq, PubMed]; Inhibition of BIN2 extends reproductive lifespan., [RefSeq, PubMed]; Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z6F3;F5H0W4;Q86VV0;Q9NWK4;Q9UKN4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005543 phospholipid binding",
        "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0034774 secretory granule lumen",
        "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0060326 cell chemotaxis;GO:0071800 podosome assembly;GO:0097320 plasma membrane tubulation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q9UBW5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N8U9-1",
        "uniprot_id": "BMPER_HUMAN",
        "mass": 75997.0,
        "length": 685,
        "protein_name": "BMP-binding endothelial regulator protein",
        "gene_name": "BMPER",
        "organism": "Human",
        "refseq_name": "BMP-binding endothelial regulator protein isoform a precursor",
        "refseq_ac": "NP_597725",
        "gene_names_uniprotkb": "BMPER; KIAA1965",
        "gene_names_refseq": "BMPER; CRIM3; CV-2; CV2",
        "protein_names_uniprotkb": "BMP-binding endothelial regulator protein; Bone morphogenetic protein-binding endothelial cell precursor-derived regulator; Protein crossveinless-2; hCV2",
        "protein_names_refseq": "BMP-binding endothelial regulator precursor protein; BMP-binding endothelial regulator protein isoform a precursor; bone morphogenetic protein-binding endothelial cell precursor-derived regulator; crossveinless 2",
        "tax_id": 9606,
        "disease": "opiate dependence (Disease Ontology:DOID:2559); diaphanospondylodysostosis (MONDO:MONDO:0011946)",
        "pathway": " (hsa:168667)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12897139;14766204;18787191;20869035;34288564;34904361;35240322;36305971;37311809",
        "class_list": "",
        "function": "BMPER alleviates ischemic brain injury by protecting neurons and inhibiting neuroinflammation via Smad3-Akt-Nrf2 pathway., [RefSeq, PubMed]; BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; BMPER is a novel BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity, [RefSeq, PubMed]; BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis., [RefSeq, PubMed]; BMPER-mediated signaling plays an essential role in vertebral segmentation early in human development, while defects in BMPER produce Diaphanospondylodysostosis., [RefSeq, PubMed]; Crossveinless-2 is an inhibitor of BMP function, [RefSeq, PubMed]; Expansion of the mutational spectrum of BMPER leading to diaphanospondylodysostosis and description of the associated disease process., [RefSeq, PubMed]; Further evidence for attenuated phenotype with variants in the BMPER gene causing DSD: Case report and literature review. Review article, [RefSeq, PubMed]; IL-6/Stat3 suppresses osteogenic differentiation in ossification of the posterior longitudinal ligament via miR-135b-mediated BMPER reduction., [RefSeq, PubMed]; Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
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        "reported_snv": 55,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1P8;Q8TF36",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005201 extracellular matrix structural constituent",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005576 extracellular region",
        "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0032880 regulation of protein localization;GO:0001568 blood vessel development;GO:0030509 BMP signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q8N8U9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H246-1",
        "uniprot_id": "CA021_HUMAN",
        "mass": 13865.0,
        "length": 121,
        "protein_name": "Uncharacterized protein C1orf21",
        "gene_name": "C1orf21",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C1orf21",
        "refseq_ac": "NP_110433",
        "gene_names_uniprotkb": "C1orf21; PIG13",
        "gene_names_refseq": "C1orf21; PIG13",
        "protein_names_uniprotkb": "Uncharacterized protein C1orf21; Cell proliferation-inducing gene 13 protein",
        "protein_names_refseq": "cell proliferation-inducing gene 13 protein; proliferation-inducing protein 13; uncharacterized protein C1orf21",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81563)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;11318611;18578522;18669648;19690332;24275569;27600516;28832583;29242379;29331515;30429286;31154438;31844290;32157095;33592498;33912179;33968037;35580925;36284347",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_o_glycosites": 0,
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        "biomarker_type": "",
        "glycan_count": 0,
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        "secondary_ac_list": "B2R551",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q9H246-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y2D0-1",
        "uniprot_id": "CAH5B_HUMAN",
        "mass": 36434.0,
        "length": 317,
        "protein_name": "Carbonic anhydrase 5B, mitochondrial",
        "gene_name": "CA5B",
        "organism": "Human",
        "refseq_name": "carbonic anhydrase 5B, mitochondrial precursor",
        "refseq_ac": "NP_009151",
        "gene_names_uniprotkb": "CA5B",
        "gene_names_refseq": "CA-VB; CA5B; CAVB",
        "protein_names_uniprotkb": "Carbonic anhydrase 5B, mitochondrial; 4.2.1.1; CA-VB; Carbonate dehydratase VB; Carbonic anhydrase VB",
        "protein_names_refseq": "carbonate dehydratase VB; carbonic anhydrase 5B, mitochondrial precursor; carbonic anhydrase 5B, mitochondrial; carbonic anhydrase VB, mitochondrial; carbonic dehydratase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11238);  (R-HSA-1475029)",
        "pathway_count": 2,
        "publication_count": 48,
        "publication_id_list": "10409679;11121027;11237011;11676494;120192;14611844;15501038;1554744;16006130;16302824;17174092;17228881;17314045;17427958;17499996;17705204;17761422;18162396;18294854;18703501;19186056;19206230;20349499;20493921;20578724;2111324;21282642;2169869;22001224;234739;26913920;29671580;3080418;32161166;33592498;36464834;4994926;6407977;6433979;6819139;7625839;8083199;8356065;8399223;9054574;9336012;9635771;9784398",
        "class_list": "",
        "function": "Activators enhanced kcat, with no effect on KM, favoring the RDS in the catalytic cycle; the activation pattern of the two mitochondrial isoforms is very different from each other and as compared to those of the cytosolic isoforms hCA I and II., [RefSeq, PubMed]; Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes carbonic anhydrase 5B. CA5B, and the related CA5A gene, has its expression localized in the mitochondria though CA5B has a wider tissue distribution than CA5A, which is restricted to the liver, kidneys, and skeletal muscle. A carbonic anhydrase pseudogene (CA5BP1) is adjacent to the CA5B gene and these two loci produce CA5BP1-CA5B readthrough transcripts. [provided by RefSeq, Jan 2019]., [RefSeq]; In 10 of 96 patients, mutations in CA5A were identified on both alleles but none in CA5B. Exhibiting decreased enzyme activity or thermal stability, all CAVA mutations were proven to cause disease, whereas the three variants showed no relevant effect Erratum:[Genet Med. 2016 Jun;18(6):649. doi: 10.1038/gim.2016.46. PMID: 27304993], [RefSeq, PubMed]; Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease. Review article, [RefSeq, PubMed]; Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 1,
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        "total_reported_n_glycosites": 1,
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        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 9803,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4T5",
        "ec_number_list": "4.2.1.1;4.2.1.69",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q9Y2D0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BTV7-1",
        "uniprot_id": "CABL2_HUMAN",
        "mass": 52235.0,
        "length": 478,
        "protein_name": "CDK5 and ABL1 enzyme substrate 2",
        "gene_name": "CABLES2",
        "organism": "Human",
        "refseq_name": "CDK5 and ABL1 enzyme substrate 2",
        "refseq_ac": "NP_112492",
        "gene_names_uniprotkb": "CABLES2; C20orf150",
        "gene_names_refseq": "C20orf150; CABLES2; dJ908M14.2; ik3-2",
        "protein_names_uniprotkb": "CDK5 and ABL1 enzyme substrate 2; Ik3-2; Interactor with CDK3 2",
        "protein_names_refseq": "CDK5 and ABL1 enzyme substrate 2; interactor with CDK3 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81928);  (R-HSA-983231)",
        "pathway_count": 2,
        "publication_count": 68,
        "publication_id_list": "11042108;11062261;11237011;11242053;11744692;11751636;11895428;11950885;12032298;12134158;12427746;14637168;15020713;15247287;15710388;16054028;1630448;17027967;17196961;18691976;19293402;19369195;20056645;20530532;20627800;218813;23481700;24715725;25576301;25645385;26154972;26845023;27920218;28228285;28832583;28904123;29242379;29351928;29393594;29557506;29632046;29632711;30315122;31092671;31217245;31844290;31937595;31998317;32157095;32265295;32350084;32897882;33298915;33912179;33936100;33968037;34087483;3409321;34433824;35051231;8662638;8816476;9065479;9230307;9326583;9331217;9422515;9927674",
        "class_list": "",
        "function": "Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator), [RefSeq, PubMed]; Unknown. Probably involved in G1-S cell cycle transition., [UniProtKB]; We thus identified ik3-2 as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
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        "reported_snv": 9,
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        "biomarker_type": "",
        "glycan_count": 2,
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        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JWL0;Q9BYK0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0051301 cell division;GO:0051726 regulation of cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q9BTV7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BYV9-1",
        "uniprot_id": "BACH2_HUMAN",
        "mass": 92537.0,
        "length": 841,
        "protein_name": "Transcription regulator protein BACH2",
        "gene_name": "BACH2",
        "organism": "Human",
        "refseq_name": "transcription regulator protein BACH2",
        "refseq_ac": "NP_001164265",
        "gene_names_uniprotkb": "BACH2",
        "gene_names_refseq": "BACH2; BTBD25; IMD60",
        "protein_names_uniprotkb": "Transcription regulator protein BACH2; BTB and CNC homolog 2",
        "protein_names_refseq": "BTB and CNC homolog 2; BTB and CNC homology 1, basic leucine zipper transcription factor 2; BTB domain and CNC homolog 2; transcription regulator protein BACH2",
        "tax_id": 9606,
        "disease": "immunodeficiency 60 (Disease Ontology:DOID:0111954)",
        "pathway": " (hsa:60468)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "10949928;11237011;11746976;17018862;22194330;25548167;27158840;28530713;29351928;32488085;32502341;32938616;32983136;33691108;35051231;35580925;37532764;38459508;38824974;38901430;39009838",
        "class_list": "",
        "function": "BACH2 is transcriptionally regulated by the BCR/ABL oncogene., [RefSeq, PubMed]; BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells., [RefSeq, PubMed]; Genetic polymorphisms of BACH2, a key gene regulating Th2 immune response, increasing risk of allergic rhinitis., [RefSeq, PubMed]; Intergenic risk variant rs56258221 skews the fate of naive CD4[+] T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis., [RefSeq, PubMed]; The role of Bach2 in regulating CD8 + T cell development and function. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713)., [UniProtKB, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
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        "reported_mutagensis": 1,
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        "reported_snv": 43,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P518;Q59H70;Q5T793;Q9NTS5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0090721 primary adaptive immune response involving T cells and B cells",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q9BYV9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96GS4-1",
        "uniprot_id": "BORC6_HUMAN",
        "mass": 37226.0,
        "length": 357,
        "protein_name": "BLOC-1-related complex subunit 6",
        "gene_name": "BORCS6",
        "organism": "Human",
        "refseq_name": "BLOC-1-related complex subunit 6",
        "refseq_ac": "NP_060092",
        "gene_names_uniprotkb": "BORCS6; C17orf59",
        "gene_names_refseq": "BORCS6; C17orf59; PRO2472",
        "protein_names_uniprotkb": "BLOC-1-related complex subunit 6; Lysosome-dispersing protein; Lyspersin",
        "protein_names_refseq": "BLOC-1-related complex subunit 6; lysosome-dispersing protein; lyspersin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54785)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "18669648;20068231;20166139;23186163;24275569;25898167;27862975;29242379;30833945;31844290;35051231;35580925;36284347;36717601",
        "class_list": "",
        "function": "As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor., [UniProtKB, PubMed]; BORC complex specific components and Kinesin-1 mediate autophagy evasion by the autophagy-resistant Mycobacterium tuberculosis Beijing strain. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53HS4;Q9NXW8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0098574 cytoplasmic side of lysosomal membrane;GO:0099078 BORC complex",
        "go_biological_process": "GO:0051036 regulation of endosome size;GO:0032418 lysosome localization;GO:0072384 organelle transport along microtubule;GO:0062196 regulation of lysosome size",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q96GS4-1",
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    },
    {
        "uniprot_canonical_ac": "Q96K17-1",
        "uniprot_id": "BT3L4_HUMAN",
        "mass": 17271.0,
        "length": 158,
        "protein_name": "Transcription factor BTF3 homolog 4",
        "gene_name": "BTF3L4",
        "organism": "Human",
        "refseq_name": "transcription factor BTF3 homolog 4 isoform 2",
        "refseq_ac": "NP_001129969",
        "gene_names_uniprotkb": "BTF3L4",
        "gene_names_refseq": "BTF3L4",
        "protein_names_uniprotkb": "Transcription factor BTF3 homolog 4; Basic transcription factor 3-like 4",
        "protein_names_refseq": "transcription factor BTF3 homolog 4 isoform 2; transcription factor BTF3 homolog 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91408)",
        "pathway_count": 1,
        "publication_count": 48,
        "publication_id_list": "11237011;18669648;22424782;22544926;23481700;25576301;26154972;27920218;28228285;28510447;28832583;29557506;29632711;29786170;30192525;30429286;31530632;31844290;31848261;32157095;32387766;32502341;32897882;32938616;32983136;33298915;33392160;33592498;33691108;33912179;33936100;33968037;34087483;34211107;34509645;34932366;35051231;35154160;35251023;35526384;35561310;35580925;36010968;36241641;36284347;37938771;38320629;39894887",
        "class_list": "",
        "function": "Basic Transcription Factor 3 Like 4 Enhances Malignant Phenotypes through Modulating Tumor Cell Function and Immune Microenvironment in Glioma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "B3KNJ1;D3DQ32;G3V1C6",
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        "record_id": "Q96K17-1",
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    },
    {
        "uniprot_canonical_ac": "Q96MC4-1",
        "uniprot_id": "C295L_HUMAN",
        "mass": 69839.0,
        "length": 621,
        "protein_name": "CEP295 N-terminal-like protein",
        "gene_name": "CEP295NL",
        "organism": "Human",
        "refseq_name": "protein DDC8 homolog isoform 2",
        "refseq_ac": "NP_001230469",
        "gene_names_uniprotkb": "CEP295NL; KIAA1731NL",
        "gene_names_refseq": "CEP295NL; DDC8; KIAA1731NL",
        "protein_names_uniprotkb": "CEP295 N-terminal-like protein; KIAA1731 N-terminal like protein",
        "protein_names_refseq": "KIAA1731 N-terminal like protein; differential display clone 8; protein DDC8 homolog isoform 2; protein DDC8 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100653515)",
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        "publication_count": 4,
        "publication_id_list": "11237011;28411811;34087483;35051231",
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0005814 centriole",
        "go_biological_process": "GO:0046599 regulation of centriole replication",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q96MC4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96MC9-1",
        "uniprot_id": "CA147_HUMAN",
        "mass": 29841.0,
        "length": 270,
        "protein_name": "Putative uncharacterized protein IKBKE-AS1",
        "gene_name": "IKBKE-AS1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IKBKE-AS1; C1orf147",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein IKBKE-AS1; IKBKE antisense RNA 1; Uncharacterized protein C1orf147",
        "protein_names_refseq": "",
        "tax_id": 9606,
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        "secondary_ac_list": "Q5JTS5",
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        "record_id": "Q96MC9-1",
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    },
    {
        "uniprot_canonical_ac": "Q9H7X2-1",
        "uniprot_id": "RDD1_HUMAN",
        "mass": 15517.0,
        "length": 142,
        "protein_name": "Required for drug-induced death protein 1",
        "gene_name": "C1orf115",
        "organism": "Human",
        "refseq_name": "required for drug-induced death protein 1",
        "refseq_ac": "NP_078985",
        "gene_names_uniprotkb": "C1orf115; RDD1",
        "gene_names_refseq": "C1orf115; RDD1",
        "protein_names_uniprotkb": "Required for drug-induced death protein 1",
        "protein_names_refseq": "Required for Drug-induced Death 1; required for drug-induced death protein 1; uncharacterized protein C1orf115",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79762)",
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        "publication_id_list": "29242379;29557506;30429286;30833945;31154438;31848261;32028983;32157095;34171305;35051231;35580925;35970996;36010968",
        "class_list": "",
        "function": "Regulates drug efflux through modulation of ABCB1 localization and activity., [UniProtKB, PubMed, PubMed]; Systematic functional identification of cancer multi-drug resistance genes. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "B3KRN3;D3DTB2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane;GO:0097731 9+0 non-motile cilium",
        "go_biological_process": "GO:2001023 regulation of response to drug",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q9H7X2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NZU7-4",
        "uniprot_id": "CABP1_HUMAN",
        "mass": 39838.0,
        "length": 370,
        "protein_name": "Calcium-binding protein 1",
        "gene_name": "CABP1",
        "organism": "Human",
        "refseq_name": "calcium-binding protein 1 isoform 3",
        "refseq_ac": "NP_001028849",
        "gene_names_uniprotkb": "CABP1",
        "gene_names_refseq": "CABP1; CALBRAIN; HCALB_BR",
        "protein_names_uniprotkb": "Calcium-binding protein 1; CaBP1; Calbrain; Caldendrin",
        "protein_names_refseq": "calcium binding protein 5; calcium-binding protein 1 isoform 3; caldendrin",
        "tax_id": 9606,
        "disease": "temporal lobe epilepsy (Disease Ontology:DOID:3328); schizophrenia (Disease Ontology:DOID:5419)",
        "pathway": " (hsa:9478);  (R-HSA-9662360)",
        "pathway_count": 2,
        "publication_count": 23,
        "publication_id_list": "10025409;10625670;11163272;11865310;12032348;14570872;14685260;15095872;15140941;15895247;15980432;16147998;19008222;21383011;21608059;22693956;22996592;24599957;24715725;28904123;31844290;9694893;9920909",
        "class_list": "",
        "function": "CaBP1 is able to specifically regulate InsP3 receptor-mediated alterations in [Ca2+]i during agonist stimulation., [RefSeq, PubMed]; CaBP1 regulates voltage-dependent inactivation and activation of Ca(V)1.2 (L-type) calcium channels, [RefSeq, PubMed]; Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012]., [RefSeq]; Different kinetics of Ca-dependent binding step between caldendrin and calmodulin with AKAP79 suggest their different roles in synaptic function., [RefSeq, PubMed]; Enhances inactivation, causes a depolarizing shift in the voltage dependence of activation, and does not support Ca2+-dependent facilitation of Ca(v)2.1 channels, [RefSeq, PubMed]; Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs) (PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed:15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Present the NMR structure of full-length CaBP1 with Ca(2+) bound at the first, third, and fourth EF-hands., [RefSeq, PubMed]; The faster migrating Tg adduct C primarily engages the CaBP1/P5 oxidoreductase, whereas the slower migrating Tg adduct A primarily engages ERp72., [RefSeq, PubMed]; We demonstrate that calmodulin and caldendrin compete for a partially overlapping binding site on AKAP79 and that their binding is differentially dependent on calcium, [RefSeq, PubMed]; We describe a new role for CaBP1 in regulation of Ca2+ influx through Ca(v)1.2 (L-type) Ca2+ channels. CaBP1 interacts directly with the alpha1 subunit of Ca(v)1.2 at sites that also bind Calmodulin, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "reported_mutagensis": 9,
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        "secondary_ac_list": "O95663;Q8N6H5;Q9NZU8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0048306 calcium-dependent protein binding;GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding;GO:0008139 nuclear localization sequence binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex",
        "go_biological_process": "GO:0007601 visual perception;GO:0042308 negative regulation of protein import into nucleus;GO:0007602 phototransduction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q9NZU7-4",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P296-1",
        "uniprot_id": "C5AR2_HUMAN",
        "mass": 36080.0,
        "length": 337,
        "protein_name": "C5a anaphylatoxin chemotactic receptor 2",
        "gene_name": "C5AR2",
        "organism": "Human",
        "refseq_name": "C5a anaphylatoxin chemotactic receptor 2",
        "refseq_ac": "NP_001258678",
        "gene_names_uniprotkb": "C5AR2; C5L2; GPR77",
        "gene_names_refseq": "C5AR2; C5L2; GPF77; GPR77",
        "protein_names_uniprotkb": "C5a anaphylatoxin chemotactic receptor 2; Complement component 5a receptor 2; G protein-coupled receptor 77",
        "protein_names_refseq": "C5a anaphylatoxin chemotactic receptor 2; C5a anaphylatoxin chemotactic receptor C5L2; G protein-coupled receptor 77; G protein-coupled receptor C5L2; complement component 5a receptor 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27202);  (R-HSA-375276);  (R-HSA-977606)",
        "pathway_count": 3,
        "publication_count": 154,
        "publication_id_list": "10079109;10100623;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10531307;10604470;1067618;10854085;10899166;11090875;11165367;11322507;11385580;11457843;11562423;11683476;11694537;11773063;11939578;12055245;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;1386357;14463577;14550283;14570896;14573733;15139756;15539556;1567413;15833747;15947423;16079145;16192651;1655761;16627811;16999828;1710450;1710578;17182573;1719979;1722333;17505110;18127230;1847994;19615750;21698200;21788512;22802338;23446738;23481700;23487775;23690594;2420889;2465906;2466593;2481448;24906252;2649896;27496565;28218747;293688;293746;29557506;2956252;2971659;301546;3202875;32161166;3366244;35051231;3525564;36466856;36593314;38067135;3848661;3856870;4098172;6214588;6219696;6222381;6230668;6238120;6274691;6281660;6334079;6373251;6454142;6589611;6607952;670886;6906228;702059;7057924;7391570;7524088;7542572;7590751;7592910;7592911;760802;761607;7624359;7690834;7691959;7797512;7905839;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8345200;8373420;8381365;8383682;8395824;8440682;8463333;8495193;8503909;8615752;8666380;8702752;873923;8786315;8823230;9038722;9171878;9521323;9530155;9593744;9607765;9685625;9722565;978134;9792798;9832121;9851594",
        "class_list": "",
        "function": "A8Delta71-73 is the first antagonist of c5a that blocks C5a and C5adesArg74 binding to C5L2 making it a valuable tool for studying C5L2 functions., [RefSeq, PubMed]; C3a des Arg77 binds to C5L2 but not to the C3a receptor (LocusID: 719).  C3a and C3a des Arg77 both stimulate triglyceride synthesis (acylation stimulating protein, ASP) in adipocytes and fibroblasts and so C5L2 could be the receptor for ASP. Erratum:[J Biol Chem. 2004 Jan 2;279(1):820], [RefSeq, PubMed]; C5L2 modulates BDNF production in human dental pulp stem cells via p38alpha pathway. Publication Status: Online-Only, [RefSeq, PubMed]; C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:11773063). Also acts as a receptor for dearginated forms of C3a, C4a and C5a anaphylatoxin peptides (ASP/C3adesArg, C4adesArg and C5adesArg, respectively) (PubMed:12540846, PubMed:15833747, PubMed:19615750). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:12540846). C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed:12540846)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; These results suggest that C5L2 is an anaphylatoxin-binding protein with unique ligand binding and signaling properties. GeneRIF: C5L2 is a high affinity binding protein for C5a and C5a des Arg74, and has a moderate affinity for C3a. Unlike the original receptors for C5a (CD88) and C3a (C3aR), C5L2 couples weakly to Gi-mediated signalling pathways., [RefSeq, PubMed]; This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RA09",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004878 complement component C5a receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045177 apical part of cell;GO:0009925 basal plasma membrane",
        "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032715 negative regulation of interleukin-6 production",
        "synthesized_glycan_count": 0,
        "hit_score": 15.5,
        "record_id": "Q9P296-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UMX3-1",
        "uniprot_id": "BOK_HUMAN",
        "mass": 23280.0,
        "length": 212,
        "protein_name": "Bcl-2-related ovarian killer protein",
        "gene_name": "BOK",
        "organism": "Human",
        "refseq_name": "bcl-2-related ovarian killer protein",
        "refseq_ac": "NP_115904",
        "gene_names_uniprotkb": "BOK; BCL2L9",
        "gene_names_refseq": "BCL2L9; BOKL; BOK",
        "protein_names_uniprotkb": "Bcl-2-related ovarian killer protein; Bcl-2-like protein 9; Bcl2-L-9; hBOK",
        "protein_names_refseq": "BCL2 related ovarian killer; BOK, BCL2 family apoptosis regulator; bcl-2-like protein 9; bcl-2-related ovarian killer protein; bcl2-L-9; hBOK",
        "tax_id": 9606,
        "disease": "hydrocephalus (Disease Ontology:DOID:10908); Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:666)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "11034351;15102863;15775999;15868100;16302269;19942931;20166139;20673843;23884412;24113155;25576301;27076518;29557506;31530632;32938616;33093207;33291826;33773141;33968037;33981976;35051231;35091677;39048751;9535847",
        "class_list": "",
        "function": "Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:15102863, PubMed:20673843, PubMed:27076518). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:15102863, PubMed:27076518). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains., [RefSeq, PubMed]; Bok binds to a largely disordered loop in the coupling domain of type 1 inositol 1,4,5-trisphosphate receptor., [RefSeq, PubMed]; Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis., [RefSeq, PubMed]; Pro-apoptotic molecule exerting its function through the mitochondrial pathway., [UniProtKB, PubMed]; The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner., [RefSeq, PubMed]; The Mysteries around the BCL-2 Family Member BOK. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0015267 channel activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0010506 regulation of autophagy;GO:0043065 positive regulation of apoptotic process;GO:0051259 protein complex oligomerization;GO:0006915 apoptotic process;GO:0051480 regulation of cytosolic calcium ion concentration",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q9UMX3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y4F5-1",
        "uniprot_id": "C170B_HUMAN",
        "mass": 171688.0,
        "length": 1589,
        "protein_name": "Centrosomal protein of 170 kDa protein B",
        "gene_name": "CEP170B",
        "organism": "Human",
        "refseq_name": "centrosomal protein of 170 kDa protein B isoform 1",
        "refseq_ac": "NP_001106197",
        "gene_names_uniprotkb": "CEP170B; FAM68C; KIAA0284",
        "gene_names_refseq": "CEP170B; CEP170R; FAM68C; KIAA0284",
        "protein_names_uniprotkb": "Centrosomal protein of 170 kDa protein B; Centrosomal protein 170B; Cep170B",
        "protein_names_refseq": "Cep170-related; centrosomal protein of 170 kDa protein B isoform 1; centrosomal protein of 170 kDa protein B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283638)",
        "pathway_count": 1,
        "publication_count": 36,
        "publication_id_list": "18669648;19690332;20068231;21406692;22028470;23186163;24275569;24715725;25576301;25645385;26758079;26992070;28411811;29557506;29786170;30379171;30484775;31844290;32157095;32387766;32488085;32938616;33592498;33912179;33968037;33981976;34087483;34171305;34509645;35051231;35580925;36010968;36215666;36241641;39894887;9179496",
        "class_list": "",
        "function": "Plays a role in microtubule organization., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 8,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 8,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 31,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2KHR7;Q86TI7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005874 microtubule",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "Q9Y4F5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NDY6-1",
        "uniprot_id": "BHE23_HUMAN",
        "mass": 23665.0,
        "length": 225,
        "protein_name": "Class E basic helix-loop-helix protein 23",
        "gene_name": "BHLHE23",
        "organism": "Human",
        "refseq_name": "class E basic helix-loop-helix protein 23",
        "refseq_ac": "NP_542173",
        "gene_names_uniprotkb": "BHLHE23; BHLHB4",
        "gene_names_refseq": "BETA4; BHLHB4; BHLHE23; Beta3b; bA305P22.3",
        "protein_names_uniprotkb": "Class E basic helix-loop-helix protein 23; Class B basic helix-loop-helix protein 4; bHLHb4; bHLHe23",
        "protein_names_refseq": "basic helix-loop-helix domain containing, class B, 4; class B basic helix-loop-helix protein 4; class E basic helix-loop-helix protein 23",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:128408)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;11863370;14516699;15363390;31844290;32502341;33298915;38253038",
        "class_list": "",
        "function": "Knockout mouse retinal dysfunction resembles human congenital stationary night blindness., [RefSeq, PubMed]; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity)., [UniProtKB]; Mouse Bhlhe23 can function as a transcriptional repressor., [RefSeq, PubMed]; This gene encodes a member of the basic helix-loop-helix transcription factor family. Members of this family contain two highly conserved and functionally distinct domains: the basic domain targets sequence-specific DNA binding, while the helix-loop-helix domain facilitates protein interaction. Studies of a related gene in mouse suggest that the encoded protein may function as a transcriptional repressor in the pancreas and brain, and that it is required for normal retinal function. [provided by RefSeq, May 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RP69",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0061564 axon development;GO:0007423 sensory organ development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q8NDY6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P36894-1",
        "uniprot_id": "BMR1A_HUMAN",
        "mass": 60198.0,
        "length": 532,
        "protein_name": "Bone morphogenetic protein receptor type-1A",
        "gene_name": "BMPR1A",
        "organism": "Human",
        "refseq_name": "bone morphogenetic protein receptor type-1A isoform 3 precursor",
        "refseq_ac": "NP_004320",
        "gene_names_uniprotkb": "BMPR1A; ACVRLK3; ALK3",
        "gene_names_refseq": "10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A; BMPR1A; CD292; SKR5",
        "protein_names_uniprotkb": "Bone morphogenetic protein receptor type-1A; 2.7.11.30; ALK-3; Activin receptor-like kinase 3; BMP type-1A receptor; BMPR-1A; SKR5; Serine/threonine-protein kinase receptor R5",
        "protein_names_refseq": "BMP type-1A receptor; activin A receptor, type II-like kinase 3; activin receptor-like kinase 3; bone morphogenetic protein receptor type-1A isoform 3 precursor; bone morphogenetic protein receptor, type IA; serine/threonine-protein kinase receptor R5",
        "tax_id": 9606,
        "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); chromosome 10q23 deletion syndrome (Disease Ontology:DOID:0060389); hereditary mixed polyposis syndrome 2 (Disease Ontology:DOID:0111686); Ebstein anomaly (Disease Ontology:DOID:14289); hamartoma (Disease Ontology:DOID:3462); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384); intestinal disease (Disease Ontology:DOID:5295); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398)",
        "pathway": " (hsa:657);  (R-HSA-201451)",
        "pathway_count": 2,
        "publication_count": 85,
        "publication_id_list": "10458166;10587654;10712517;10881198;11016919;11121043;11158580;11237011;11278251;11381269;11509558;11536076;11571290;11714695;11779505;12136244;12151385;12417513;12519765;12592392;12630959;12821673;12857866;15064755;16525031;16672363;16685657;17029022;17068149;17081983;17295905;17311849;17344846;17356069;18937504;19726563;20112406;21791611;22799562;24098149;24397554;24715725;25860647;26154972;28218747;28832583;28834231;28847510;29242379;29437277;29786170;30315122;31800957;32157095;32350084;32357974;32938616;33141586;33298915;33308444;33592498;33912179;33968037;34171305;34211107;34357683;34743989;34932366;35051231;35154160;35251023;36049049;37485765;38192234;38783645;40854140;7644468;7791754;8006002;8119126;8397373;8653785;8893010;9136927;9436979",
        "class_list": "",
        "function": "Adenomatous Polyposis Phenotype in BMPR1A and SMAD4 Variant Carriers. Publication Status: Online-Only, [RefSeq, PubMed]; Hsa-miR-27b-5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study., [RefSeq, PubMed]; Nonsense suppression induces read-through of a novel BMPR1A variant in a Chinese family with hereditary colorectal cancer., [RefSeq, PubMed]; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity)., [UniProtKB, UniProtKB]; The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]., [RefSeq]; ZEB1-AS1 mediates bone metastasis through targeting miR-320b/BMPR1A axis in lung cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 9,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6U9;Q8NEN8",
        "ec_number_list": "2.7.11.30;2.3.2.26",
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0004675 transmembrane receptor protein serine/threonine kinase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043235 receptor complex",
        "go_biological_process": "GO:0003171 atrioventricular valve development;GO:0001525 angiogenesis;GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 8.7,
        "record_id": "P36894-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "B2RXH4-1",
        "uniprot_id": "BTBDI_HUMAN",
        "mass": 77931.0,
        "length": 712,
        "protein_name": "BTB/POZ domain-containing protein 18",
        "gene_name": "BTBD18",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing protein 18",
        "refseq_ac": "NP_001138573",
        "gene_names_uniprotkb": "BTBD18",
        "gene_names_refseq": "BTBD18",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein 18",
        "protein_names_refseq": "BTB (POZ) domain containing 18; BTB/POZ domain-containing protein 18; hCG1730474",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:643376)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;31530632;31844290;32488085;34087483;35051231",
        "class_list": "",
        "function": "Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007141 male meiosis I;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0010526 transposable element silencing",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "B2RXH4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "B7Z1M9-1",
        "uniprot_id": "C2D4D_HUMAN",
        "mass": 37583.0,
        "length": 353,
        "protein_name": "C2 calcium-dependent domain-containing protein 4D",
        "gene_name": "C2CD4D",
        "organism": "Human",
        "refseq_name": "C2 calcium-dependent domain-containing protein 4D",
        "refseq_ac": "NP_001129475",
        "gene_names_uniprotkb": "C2CD4D; FAM148D",
        "gene_names_refseq": "C2CD4D; FAM148D",
        "protein_names_uniprotkb": "C2 calcium-dependent domain-containing protein 4D",
        "protein_names_refseq": "C2 calcium-dependent domain-containing protein 4D; family with sequence similarity 148, member D",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100191040)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "35051231;38665916",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
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        "secondary_ac_list": "B2RXG8",
        "ec_number_list": "",
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        "hit_score": 0.5,
        "record_id": "B7Z1M9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BXJ3-1",
        "uniprot_id": "C1QT4_HUMAN",
        "mass": 35256.0,
        "length": 329,
        "protein_name": "Complement C1q tumor necrosis factor-related protein 4",
        "gene_name": "C1QTNF4",
        "organism": "Human",
        "refseq_name": "complement C1q tumor necrosis factor-related protein 4 precursor",
        "refseq_ac": "NP_114115",
        "gene_names_uniprotkb": "C1QTNF4; CTRP4",
        "gene_names_refseq": "C1QTNF4; CTRP4; ZACRP4",
        "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 4; C1q/TNF-related protein 4",
        "protein_names_refseq": "C1q and tumor necrosis factor related protein 4; C1q/TNF-related protein 4; complement C1q tumor necrosis factor-related protein 4 precursor; complement C1q tumor necrosis factor-related protein 4; complement-c1q tumor necrosis factor-related protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:114900)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;16094384;19664994;21658842;24366864;24715725;27086950;29177435;29557506;29721947;31844290;33592498;34801485;35598316;36787473;38016337;38253038;38286878",
        "class_list": "",
        "function": "Association of serum CTRP4 levels with vascular endothelial function in patients with type 2 diabetes mellitus: CTRP4 ameliorating inflammation, proliferation and migration in human umbilical vein endothelial cells., [RefSeq, PubMed]; C1q tumor necrosis factor-related protein 4 is associated with coronary artery disease in patients with type 2 diabetes., [RefSeq, PubMed]; CTRP4 ameliorates inflammation, thereby attenuating the interaction between HUVECs and THP-1 monocytes through SIRT6/Nrf2 signaling., [RefSeq, PubMed]; CTRP4 is a novel tumor-promoting inflammatory regulator., [RefSeq, PubMed]; In a Pakistani family with retinal degeneration, whole-exome sequencing identified 2 homozygous missense variants: c.1304G>A; p.Arg435Gln in ZNF408 (NM_024741) and c.902G>A; p.Gly301Asp in C1QTNF4 (NM_031909). Both segregated with the retinal phenotype in this family and were absent in ethnically matched control chromosomes., [RefSeq, PubMed]; Increased serum C1q/TNF-related protein 4 concentration in patients with acute coronary syndrome., [RefSeq, PubMed]; May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent (PubMed:21658842, PubMed:27086950). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 hours post-injection (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Serum C1q/TNF-Related Protein 4 Levels are Associated with Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients., [RefSeq, PubMed]; These results establish CTRP4 as a novel nutrient-responsive central regulator of food intake and energy balance., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
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        "secondary_ac_list": "Q8IV25",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005125 cytokine activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region",
        "go_biological_process": "GO:0070105 positive regulation of interleukin-6-mediated signaling pathway;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0032755 positive regulation of interleukin-6 production;GO:0032760 positive regulation of tumor necrosis factor production",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q9BXJ3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NFQ5-1",
        "uniprot_id": "BPIB6_HUMAN",
        "mass": 49717.0,
        "length": 453,
        "protein_name": "BPI fold-containing family B member 6",
        "gene_name": "BPIFB6",
        "organism": "Human",
        "refseq_name": "BPI fold-containing family B member 6 precursor",
        "refseq_ac": "NP_777557",
        "gene_names_uniprotkb": "BPIFB6; BPIL3",
        "gene_names_refseq": "BPIFB6; BPIL3; LPLUNC6",
        "protein_names_uniprotkb": "BPI fold-containing family B member 6; Bactericidal/permeability-increasing protein-like 3",
        "protein_names_refseq": "BPI fold-containing family B member 6 precursor; bactericidal/permeability-increasing protein-like 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:128859);  (R-HSA-6803157)",
        "pathway_count": 2,
        "publication_count": 69,
        "publication_id_list": "11120840;11237011;11313366;11389039;11971875;12185532;12493837;13816;14506276;14739326;1522221;15229136;15778384;15826377;15956276;16054449;16215847;16336202;16354652;16354654;16374474;16799473;16931762;16940129;17363965;17502600;17567961;17964057;18021746;18160480;18185531;18673279;19095652;19179970;19254208;19818633;20103720;20180804;20237496;20382864;20395631;20510021;20845358;21076407;21787330;22262861;22327069;22455996;22701042;23302724;23426625;24219363;24256734;25075772;25461571;25596890;26148048;26962226;27089320;28411811;29557506;32488085;3286634;33392160;35051231;35494241;9523110;9665269;9756476",
        "class_list": "",
        "function": "BPIL3 maps to Chromosome 20q11; thus, these novel genes form a cluster with BPI and two other members of the LT/LBP gene family on the long arm of human Chr 20. AA sequence is reported., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Study reports on the cellular function of BPIFB6 in the regulation of secretory pathway trafficking and Golgi complex morphology; in addition, findings show that BPIFB6 functions as a positive regulator of enterovirus replication via its regulation of the secretory pathway Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
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        "reported_c_glycosites_with_glycan": 0,
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        "reported_phosphosites": 2,
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        "reported_interactions": 0,
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        "biomarker_type": "",
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        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q8NFQ5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q1RMZ1-1",
        "uniprot_id": "SAMTR_HUMAN",
        "mass": 46324.0,
        "length": 405,
        "protein_name": "S-adenosylmethionine sensor upstream of mTORC1",
        "gene_name": "SAMTOR",
        "organism": "Human",
        "refseq_name": "S-adenosylmethionine sensor upstream of mTORC1",
        "refseq_ac": "NP_689769",
        "gene_names_uniprotkb": "SAMTOR; BMT2; C7orf60",
        "gene_names_refseq": "BMT2; C7orf60; SAMTOR",
        "protein_names_uniprotkb": "S-adenosylmethionine sensor upstream of mTORC1; 2.1.1.-; Probable methyltransferase BMT2 homolog",
        "protein_names_refseq": "S-adenosylmethionine sensor upstream of mTORC1; UPF0532 protein C7orf60; base methyltransferase of 25S rRNA 2 homolog; probable methyltransferase BMT2 homolog; probable methyltransferase BTM2 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:154743);  (R-HSA-9639288)",
        "pathway_count": 2,
        "publication_count": 65,
        "publication_id_list": "11237011;15854902;15878852;16098514;17470430;18497260;18604198;20381137;22053050;22575674;22980980;23723238;24081491;24095279;25259925;25263562;25457612;25561175;25567906;25819761;25892735;26449471;26586190;26972053;27308486;27487210;27648300;28066558;28199306;28199315;28218747;28228285;28832583;28904123;29053970;29056322;29123071;29236692;29242379;29393594;29437277;29557506;29590090;29786170;30061680;30181260;30315122;30379171;30651352;31844290;31848261;32161166;32350084;32387766;32938616;32983136;33691108;33717175;33968037;34509645;34561969;35051231;35776786;36010968;7499430",
        "class_list": "",
        "function": "S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071, PubMed:35776786). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071, PubMed:35776786). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071, PubMed:35776786). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential)., [UniProtKB, HAMAP, PubMed, PubMed]",
        "predicted_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N3D0;Q96MV7",
        "ec_number_list": "7.1.2.2;2.7.10.2;2.7.11.1;1.11.1.-;3.6.5.-;2.1.1.-;2.3.2.27",
        "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0008168 methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0032259 methylation;GO:0034198 cellular response to amino acid starvation;GO:1903432 regulation of TORC1 signaling;GO:0061431 cellular response to methionine",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q1RMZ1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9GZN4-1",
        "uniprot_id": "BSSP4_HUMAN",
        "mass": 33732.0,
        "length": 317,
        "protein_name": "Brain-specific serine protease 4",
        "gene_name": "PRSS22",
        "organism": "Human",
        "refseq_name": "brain-specific serine protease 4 precursor",
        "refseq_ac": "NP_071402",
        "gene_names_uniprotkb": "PRSS22; BSSP4; PRO343; PRSS26; SP001LA",
        "gene_names_refseq": "BSSP-4; PRSS22; SP001LA; hBSSP-4",
        "protein_names_uniprotkb": "Brain-specific serine protease 4; 3.4.21.-; BSSP-4; Serine protease 22; Serine protease 26; Tryptase epsilon",
        "protein_names_refseq": "brain-specific serine protease 4 precursor; brain-specific serine protease 4; prosemin; protease, serine 22; protease, serine S1 family member 22; serine protease 26; tryptase epsilon",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64063)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;11602603;12975309;15701722;16176265;23090970;24190977;24980078;29242379;29557506;30784271;35494241;39894887",
        "class_list": "",
        "function": "Our findings collectively support a potential role of T3 in cancer cell progression through regulation of the BSSP4 protease via the ERK 1/2-C/EBPbeta-VEGF cascade Publication Status: Online-Only, [RefSeq, PubMed]; Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA., [UniProtKB, PubMed]; Prosemin is a novel serine protease of the chromosome 16 cluster that is highly expressed in the pancreas., [RefSeq, PubMed]; This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]., [RefSeq]; Tryptase epsilon also was able to induce pro-uPA-expressing smooth muscle cells to increase their migration, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43342;Q6UXE0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0016504 peptidase activator activity;GO:0008236 serine-type peptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0010952 positive regulation of peptidase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q9GZN4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00499-1",
        "uniprot_id": "BIN1_HUMAN",
        "mass": 64699.0,
        "length": 593,
        "protein_name": "Myc box-dependent-interacting protein 1",
        "gene_name": "BIN1",
        "organism": "Human",
        "refseq_name": "myc box-dependent-interacting protein 1 isoform 13",
        "refseq_ac": "NP_001307561",
        "gene_names_uniprotkb": "BIN1; AMPHL",
        "gene_names_refseq": "AMPH2; AMPHL; BIN1; CNM2; SH3P9",
        "protein_names_uniprotkb": "Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1",
        "protein_names_refseq": "amphiphysin 2; amphiphysin II; amphiphysin-like protein; box dependant MYC interacting protein 1; box-dependent myc-interacting protein 1; myc box-dependent-interacting protein 1 isoform 13",
        "tax_id": 9606,
        "disease": "centronuclear myopathy 2 (Disease Ontology:DOID:0111220); prostate adenocarcinoma (Disease Ontology:DOID:2526); breast carcinoma (Disease Ontology:DOID:3459)",
        "pathway": " (hsa:274);  (R-HSA-8856828)",
        "pathway_count": 2,
        "publication_count": 194,
        "publication_id_list": "10535736;10542231;10559856;10559861;10559924;10625686;10766823;10903846;11082044;11231140;11239472;11470803;11516654;11517213;11532990;11577110;11877457;11877461;11889126;12057195;12213833;12447393;12668730;12847086;12952949;14555962;14581451;14617351;14622578;14622579;15252009;15260957;15302935;15318165;15339664;15502812;15502813;15649145;15703209;15802264;15895077;15916959;16103228;16215232;16326391;16410077;16516836;16530520;16707488;16798879;16880396;16903783;17018281;17035995;17081983;17158794;17322306;17494869;17512409;17540576;17609109;17676042;17681954;17762867;17765681;17924679;17978091;18093523;18212344;18388313;18452278;1847920;18510355;18669648;18767875;18790740;18981233;19092055;19287005;19296720;19367720;19413330;19415658;19458185;19531498;19536138;19575674;19603039;19651622;19664994;19696796;19713939;19776351;19809571;20033059;20058876;20059951;20068231;20142620;20166139;20211604;20231386;20428113;20448150;20826345;20946875;2115402;21187331;21278753;21316588;21445324;21482805;21499258;21613550;21779028;21841790;21883765;21927000;21927001;21962517;22099461;22233676;22484487;22505844;22815487;22863004;23186163;23297414;23536704;23823722;23861397;23891661;24130457;24186068;24275569;24581490;24755653;24789820;24966051;25107275;25260562;25303366;25341920;25505266;26042225;26403691;26811146;26992070;27179792;27488240;28228285;28510447;28893863;28904123;29351928;29393594;29493099;29557506;29950440;31844290;32157095;32350084;32897882;32938616;33912179;33968037;33981976;35008409;35051231;35580925;36241641;37847429;38460121;38514804;38724689;40596516;40914422;6146630;7877694;8524399;8552632;8782822;9092476;9100026;9182667;9195986;9223448;9395479;9418903;9427626;9428629;9603201;9635431;9736607",
        "class_list": "",
        "function": "A nucleocytosolic myc-interacting isoform of Bin1 has properties of a tumor suppressor., [RefSeq, PubMed]; BIN1 in the Pursuit of Ousting the Alzheimer's Reign: Impact on Amyloid and Tau Neuropathology. Review article, [RefSeq, PubMed]; BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation. Publication Status: Online-Only, [RefSeq, PubMed]; BIN1[K358R] suppresses glial response to plaques in mouse model of Alzheimer's disease., [RefSeq, PubMed]; Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The Alzheimer's disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neurons., [RefSeq, PubMed]; This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O00297;O00545;O43867;O60552;O60553;O60554;O60555;O75514;O75515;O75516;O75517;O75518;Q659B7;Q92944;Q99688",
        "ec_number_list": "",
        "go_molecular_function": "GO:0002020 protease binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0051087 protein-folding chaperone binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome",
        "go_biological_process": "GO:1901380 negative regulation of potassium ion transmembrane transport;GO:1904878 negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006897 endocytosis;GO:0043065 positive regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 19.8,
        "record_id": "O00499-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60477-1",
        "uniprot_id": "BRNP1_HUMAN",
        "mass": 88760.0,
        "length": 761,
        "protein_name": "BMP/retinoic acid-inducible neural-specific protein 1",
        "gene_name": "BRINP1",
        "organism": "Human",
        "refseq_name": "BMP/retinoic acid-inducible neural-specific protein 1 precursor",
        "refseq_ac": "NP_055433",
        "gene_names_uniprotkb": "BRINP1; DBC1; DBCCR1; FAM5A; IB3089A",
        "gene_names_refseq": "BRINP1; DBC1; DBCCR1; FAM5A",
        "protein_names_uniprotkb": "BMP/retinoic acid-inducible neural-specific protein 1; Deleted in bladder cancer protein 1",
        "protein_names_refseq": "BMP/retinoic acid-inducible neural-specific protein 1 precursor; BMP/retinoic acid-inducible neural-specific protein 1; bA574M5.1 (deleted in bladder cancer chromosome region candidate 1 (IB3089A)); bone morphogenetic protein/retinoic acid inducible neural-specific 1; bone morphogenic protein/retinoic acid inducible neural-specific 1; deleted in bladder cancer 1; deleted in bladder cancer chromosome region candidate 1; deleted in bladder cancer protein 1",
        "tax_id": 9606,
        "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); autism spectrum disorder (Disease Ontology:DOID:0060041); isolated growth hormone deficiency (Disease Ontology:DOID:0060870); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); osteoporosis (Disease Ontology:DOID:11476); osteopetrosis (Disease Ontology:DOID:13533); familial hypercholesterolemia (Disease Ontology:DOID:13810); breast cancer (Disease Ontology:DOID:1612); colonic disease (Disease Ontology:DOID:5353); muscular atrophy (Disease Ontology:DOID:767); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); Laron syndrome (Disease Ontology:DOID:9521); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:1620)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "11420708;14712213;16959974;22465953;23349863;23398316;23481700;28427182;30379171;32157095;32387766;33592498;33981976;35051231;9545632",
        "class_list": "",
        "function": "DBC1 modulates the stability and function of the nuclear receptor Rev-erb-alpha., [RefSeq, PubMed]; Plays a role in neurogenesis and brain development (By similarity). May suppress cell cycle progression in postmitotic neurons by inhibiting G1/S transition (PubMed:11420708)., [UniProtKB, PubMed, UniProtKB]; Results found that the expression of DBCCR1 is significantly lower in the lung cancer tissues compared with adjacent non-tumor tissues of patients, and correlates with more advanced stages of cancer, and shorter survival of patients. Interestingly, DBCCR1 attenuates the expression of DNMT1, suggesting a reciprocal regulation between genetic silencing of cancer suppressor genes and activating DNA methylation., [RefSeq, PubMed]; The stress-induced DBC1-SIRT1 interaction is important for cell fate determination following genotoxic stress., [RefSeq, PubMed]; This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers.  It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. [provided by RefSeq, Jul 2008]., [RefSeq]; We found that the SIRT1 modulators AROS and DBC1 have an impact on hsp70 transcription, HSF1 acetylation status, and HSF1 recruitment to the hsp70 promoter, [RefSeq, PubMed]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 7,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 71,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 14,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IPV6;Q6P1A0;Q8WU22",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0045666 positive regulation of neuron differentiation;GO:0071300 cellular response to retinoic acid;GO:0007420 brain development;GO:0045930 negative regulation of mitotic cell cycle;GO:0021954 central nervous system neuron development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "O60477-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95972-1",
        "uniprot_id": "BMP15_HUMAN",
        "mass": 45055.0,
        "length": 392,
        "protein_name": "Bone morphogenetic protein 15",
        "gene_name": "BMP15",
        "organism": "Human",
        "refseq_name": "bone morphogenetic protein 15 preproprotein",
        "refseq_ac": "NP_005439",
        "gene_names_uniprotkb": "BMP15; GDF9B",
        "gene_names_refseq": "BMP15; GDF9B; ODG2; POF4",
        "protein_names_uniprotkb": "Bone morphogenetic protein 15; BMP-15; GDF-9B; Growth/differentiation factor 9B",
        "protein_names_refseq": "bone morphogenetic protein 15 preproprotein; growth/differentiation factor 9B",
        "tax_id": 9606,
        "disease": "ovarian dysgenesis 2 (Disease Ontology:DOID:0080494); primary ovarian insufficiency (Disease Ontology:DOID:5426)",
        "pathway": " (hsa:9210);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 3,
        "publication_count": 82,
        "publication_id_list": "10026136;10077652;10218588;10443672;10512690;10614670;10681634;10810289;10898936;10912521;10951195;10990447;11158056;11250653;11264294;11316783;11522292;11606061;11739083;11751371;11788658;12241545;12379487;12466191;12810533;12904166;1370451;1383255;15126567;15136966;15308688;15469690;15485880;15525596;15642270;16464940;16508750;16645022;16788381;17047378;17249697;17312271;17985932;18227435;19263482;19438907;21970812;2476804;2479552;25892735;26091039;28585349;33392160;34087483;34171305;34187539;35051231;35232444;35861920;36372988;36689045;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;8781553;8817670;8894645;8964575;9497324;9709957;9733769;9786878;9849956;9922210",
        "class_list": "",
        "function": "Characterization of a novel mutation V136L in bone morphogenetic protein 15 identified in a woman affected by POI. Publication Status: Online-Only, [RefSeq, PubMed]; Decreased GDF9 and BMP15 in follicle fluid and granulosa cells and outcomes of IVF-ET among young patients with low prognosis., [RefSeq, PubMed]; Identification of novel biallelic variants in BMP15 in two siblings with premature ovarian insufficiency., [RefSeq, PubMed]; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth., [UniProtKB, PubMed]; Novel bone morphogenetic protein 15 (BMP15) gene variants implicated in premature ovarian insufficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Serum GDF9 and BMP15 as potential markers of ovarian function in women with and without polycystic ovary syndrome., [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q17RM6;Q5JST1;Q9UMS1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0007292 female gamete generation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "O95972-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P02745-1",
        "uniprot_id": "C1QA_HUMAN",
        "mass": 26017.0,
        "length": 245,
        "protein_name": "Complement C1q subcomponent subunit A",
        "gene_name": "C1QA",
        "organism": "Human",
        "refseq_name": "complement C1q subcomponent subunit A precursor",
        "refseq_ac": "NP_001334395",
        "gene_names_uniprotkb": "C1QA",
        "gene_names_refseq": "C1QA; C1QD1",
        "protein_names_uniprotkb": "Complement C1q subcomponent subunit A",
        "protein_names_refseq": "complement C1q chain A; complement C1q subcomponent subunit A precursor; complement C1q subcomponent subunit A; complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, alpha polypeptide; complement component C1q, A chain",
        "tax_id": 9606,
        "disease": "iron deficiency anemia (Disease Ontology:DOID:11758); epilepsy (Disease Ontology:DOID:1826); glomerulonephritis (Disease Ontology:DOID:2921); systemic lupus erythematosus (Disease Ontology:DOID:9074); C1Q deficiency 1 (MONDO:MONDO:0958182)",
        "pathway": " (hsa:712);  (R-HSA-166663);  (R-HSA-173623);  (R-HSA-977606);  (R-HSA-9920588)",
        "pathway_count": 5,
        "publication_count": 121,
        "publication_id_list": "10531307;10607312;1067618;10925294;11237011;11694537;11939578;12055245;12396008;1249422;12847249;12960167;1386357;1398737;14280442;15199963;16079145;16192651;16335952;16999828;1706597;17182573;17505110;18250442;18496526;19006321;19159218;19706439;19754307;20548024;21566123;21788512;22802338;23090970;23487775;23650384;23719902;23720782;24173023;2420889;24626930;2465906;2466593;2481448;26992070;27452731;27726376;27832191;27862975;28325905;28764923;293688;293746;29449492;29557506;2956252;29563915;29671580;2971659;29741879;29786170;2988513;301546;30429286;30550790;31154438;31848261;31867016;32152943;32157095;32432721;32536911;3258649;32778820;34155115;35051231;35580925;36284347;37074911;37138875;37550830;38155969;38179058;3848661;4098172;486087;6019133;6214588;6218163;6219696;6222381;6230668;6238120;6249812;6334079;6454142;6607952;670886;6776418;6906228;6952210;6981411;702059;70787;708376;7391570;7391573;7542572;760802;761607;7690834;7691959;814163;8345200;8495193;8538770;8786315;9038722;9324355;9777412;978134",
        "class_list": "",
        "function": "An integrative analysis of single-cell and bulk transcriptome and bidirectional mendelian randomization analysis identified C1Q as a novel stimulated risk gene for Atherosclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Association between serum complement 1q and the associated factors of acute ischemic stroke in patients with type 2 diabetes., [RefSeq, PubMed]; Complement C1q and von Willebrand factor interaction in atherosclerosis of human carotid artery. Publication Status: Online-Only, [RefSeq, PubMed]; Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:12847249, PubMed:19006321, PubMed:24626930, PubMed:29449492, PubMed:3258649, PubMed:34155115, PubMed:6249812, PubMed:6776418). The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain (PubMed:12847249, PubMed:19006321, PubMed:24626930, PubMed:29449492, PubMed:3258649, PubMed:6776418). Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system (PubMed:29449492). The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM (PubMed:19706439, PubMed:24626930, PubMed:29449492). The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system (PubMed:18250442)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 4,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 8657,
        "biomarker_type": "",
        "glycan_count": 47,
        "disease_count": 5,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4X2;Q5T963",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0001786 phosphatidylserine binding;GO:0001791 IgM binding;GO:0019864 IgG binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098888 extrinsic component of presynaptic membrane;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005576 extracellular region;GO:0009986 cell surface",
        "go_biological_process": "GO:0001774 microglial cell activation;GO:0007267 cell-cell signaling;GO:0016322 neuron remodeling;GO:0045087 innate immune response;GO:0048143 astrocyte activation",
        "synthesized_glycan_count": 0,
        "hit_score": 17.4,
        "record_id": "P02745-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0C6P0-1",
        "uniprot_id": "BCL8_HUMAN",
        "mass": 11233.0,
        "length": 100,
        "protein_name": "Putative protein BCL8",
        "gene_name": "NBEAP1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "NBEAP1; BCL8A; BCL8",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative protein BCL8; Neurobeachin pseudogene 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "12160729;9159141",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
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        "disease_count": 0,
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        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "P0C6P0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0DN25-1",
        "uniprot_id": "C1C1L_HUMAN",
        "mass": 36396.0,
        "length": 315,
        "protein_name": "C1GALT1-specific chaperone 1-like protein",
        "gene_name": "C1GALT1C1L",
        "organism": "Human",
        "refseq_name": "C1GALT1-specific chaperone 1-like protein",
        "refseq_ac": "NP_001094800",
        "gene_names_uniprotkb": "C1GALT1C1L",
        "gene_names_refseq": "C1GALT1C1L",
        "protein_names_uniprotkb": "C1GALT1-specific chaperone 1-like protein",
        "protein_names_refseq": "C1GALT1-specific chaperone 1-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:728819)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "10.1101/2023.09.13.557529;31492838;33968037;37217939",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
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        "mined_o_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "GO:0006493 protein O-linked glycosylation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "P0DN25-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P19099-1",
        "uniprot_id": "C11B2_HUMAN",
        "mass": 57560.0,
        "length": 503,
        "protein_name": "Cytochrome P450 11B2, mitochondrial",
        "gene_name": "CYP11B2",
        "organism": "Human",
        "refseq_name": "cytochrome P450 11B2, mitochondrial precursor",
        "refseq_ac": "NP_000489",
        "gene_names_uniprotkb": "CYP11B2",
        "gene_names_refseq": "ALDOS; CPN2; CYP11B2; CYP11BL; CYP11B; CYPXIB2; P-450C18; P450C18; P450aldo",
        "protein_names_uniprotkb": "Cytochrome P450 11B2, mitochondrial; 1.14.15.4; 1.14.15.5; ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; CYPXIB2; Corticosterone 18-monooxygenase, CYP11B2; Cytochrome P-450Aldo; Cytochrome P-450C18; Steroid 11-beta-hydroxylase, CYP11B2; Steroid 18-hydroxylase",
        "protein_names_refseq": "aldosterone synthase; aldosterone-synthesizing enzyme; corticosterone 18-monooxygenase, CYP11B2; cytochrome P-450Aldo; cytochrome P-450C18; cytochrome P450 11B2, mitochondrial precursor; cytochrome P450 11B2, mitochondrial; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; steroid 11-beta-hydroxylase, CYP11B2; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo",
        "tax_id": 9606,
        "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); adrenal cortical adenoma (Disease Ontology:DOID:0050891); stroke (Disease Ontology:DOID:0051061); corticosterone methyloxidase deficiency 1 (Disease Ontology:DOID:0080626); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); primary hyperaldosteronism (Disease Ontology:DOID:446); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); corticosterone methyloxidase type 2 deficiency (MONDO:MONDO:0012524)",
        "pathway": " (hsa:1585);  (R-HSA-193993);  (R-HSA-194002);  (R-HSA-211976);  (R-HSA-5579009)",
        "pathway_count": 5,
        "publication_count": 57,
        "publication_id_list": "10391209;10391210;10588945;11238478;11555828;11856349;12530636;12788848;12832414;1346492;15042513;1518866;15356073;1594605;1708392;1741400;1775135;1885595;1944309;19661213;20149798;20200334;2040591;21636783;2243100;22446688;2256920;22772592;23322723;23685396;25880248;2592361;2770297;2889032;3024157;3038528;3299377;33189850;3487786;35051231;35848593;36036158;36070092;37372364;38478114;7195404;8439335;8619637;9139807;9177280;9360501;9536209;9578606;9625333;9814482;9814506;9931115",
        "class_list": "",
        "function": "A cytochrome P450 monooxygenase that catalyzes the biosynthesis of aldosterone, the main mineralocorticoid in the human body responsible for salt and water homeostasis, thus involved in blood pressure regulation, arterial hypertension, and the development of heart failure (PubMed:11856349, PubMed:12530636, PubMed:1518866, PubMed:15356073, PubMed:1594605, PubMed:1775135, PubMed:22446688, PubMed:23322723, PubMed:9814482, PubMed:9814506). Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone (21-hydroxyprogesterone), namely 11-beta hydroxylation, followed by two successive oxidations at C18 yielding 18-hydroxy and then 18-oxo intermediates (that would not leave the enzyme active site during the consecutive hydroxylation reactions), ending with the formation of aldosterone (PubMed:11856349, PubMed:12530636, PubMed:1518866, PubMed:1594605, PubMed:1775135, PubMed:22446688, PubMed:23322723, PubMed:9814506). Can also produce 18-hydroxycortisol and 18-oxocortisol, derived from successive oxidations of cortisol at C18, normally found at very low levels, but significantly increased in primary aldosteronism, the most common form of secondary hypertension (PubMed:15356073, PubMed:9814482). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:11856349, PubMed:1594605, PubMed:23322723, PubMed:23685396, PubMed:9814506). Besides its role in the biosynthesis of mineralocorticoids and glucocorticoids, it can also participate in the androgen metabolic pathway, converting testosterone (17beta-hydroxy-4-androsten-3-one) to 11beta,17beta-dihydroxyandrost-4-ene-3-one (PubMed:23685396). Can also use progesterone as substrate (PubMed:33189850)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Association between Aldosterone Synthase (CYP11B2) Gene Polymorphism and Hypertension in Pashtun Ethnic Population of Khyber Pakhtunkwha, Pakistan. Publication Status: Online-Only, [RefSeq, PubMed]; Association of combined -344T/C and K173R polymorphisms in aldosterone synthase gene with type 2 diabetes mellitus in the Moroccan population. Publication Status: Online-Only, [RefSeq, PubMed]; Changes of the CYP11B2 Expressing Zona Glomerulosa in Human Adrenals From Birth to 40 Years of Age., [RefSeq, PubMed]; Functional nodules in primary aldosteronism: identification of CXCR4 expression with [68]Ga-pentixafor PET/CT., [RefSeq, PubMed]; Identification of a Novel CYP11B2 Variant in a Family with Varying Degrees of Aldosterone Synthase Deficiency., [RefSeq, PubMed]; This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 11,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0ZBE4;Q16726",
        "ec_number_list": "1.14.15.4;1.14.15.5",
        "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004507 steroid 11-beta-monooxygenase activity;GO:0008395 steroid hydroxylase activity;GO:0047783 corticosterone 18-monooxygenase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0003091 renal water homeostasis;GO:0008203 cholesterol metabolic process;GO:0032870 cellular response to hormone stimulus;GO:0006700 C21-steroid hormone biosynthetic process;GO:0016125 sterol metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "P19099-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P43251-4",
        "uniprot_id": "BTD_HUMAN",
        "mass": 58913.0,
        "length": 523,
        "protein_name": "Biotinidase",
        "gene_name": "BTD",
        "organism": "Human",
        "refseq_name": "biotinidase isoform 1 precursor",
        "refseq_ac": "NP_001268654",
        "gene_names_uniprotkb": "BTD",
        "gene_names_refseq": "BTD",
        "protein_names_uniprotkb": "Biotinidase; 3.5.1.12; Biotinase",
        "protein_names_refseq": "biocytinase; biotinase; biotinidase isoform 1 precursor",
        "tax_id": 9606,
        "disease": "biotinidase deficiency (Disease Ontology:DOID:856)",
        "pathway": " (hsa:686);  (R-HSA-196780);  (R-HSA-3371598)",
        "pathway_count": 3,
        "publication_count": 40,
        "publication_id_list": "10.1101/2023.09.13.557529;10064314;10206677;10329687;10334869;10677481;10801053;11668630;12646417;14766011;16134170;16150625;16335952;18297087;19139490;19159218;20153287;21183659;22123817;23090970;23550138;24190977;2868710;30379171;37074911;37119528;37751899;38299772;6883721;7509806;7550325;7732023;7758201;8930409;9099842;9375914;9530634;9630604;9654207;9705240",
        "class_list": "",
        "function": "Biotinidase biochemical and molecular analyses: Experience at a large reference laboratory., [RefSeq, PubMed]; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation., [UniProtKB, PubMed, PubMed]; Evaluation of 700 patients referred with a preliminary diagnosis of biotinidase deficiency by the national newborn metabolic screening program: a single-center experience. Publication Status: Online-Only, [RefSeq, PubMed]; Review of mutations causing biotinidase deficiency Review article, [RefSeq, PubMed]; Sequence variants in the BTD underlying biotinidase deficiency in families of Pakistani origin., [RefSeq, PubMed]; The protein encoded by this gene functions to recycle protein-bound biotin by cleaving biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. The encoded protein has also been shown to have biotinyl transferase activity. Mutations in this gene are associated with biotinidase deficiency. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 7,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 43,
        "disease_count": 1,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NHF2;B2R865;B4DFX1;B4DLJ9;B7Z7C9;F8W1Q3;Q96EM9",
        "ec_number_list": "3.5.1.12",
        "go_molecular_function": "GO:0047708 biotinidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005759 mitochondrial matrix;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006768 biotin metabolic process;GO:0007417 central nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 9.2,
        "record_id": "P43251-4",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P59826-1",
        "uniprot_id": "BPIB3_HUMAN",
        "mass": 49887.0,
        "length": 472,
        "protein_name": "BPI fold-containing family B member 3",
        "gene_name": "BPIFB3",
        "organism": "Human",
        "refseq_name": "BPI fold-containing family B member 3 precursor",
        "refseq_ac": "NP_001363861",
        "gene_names_uniprotkb": "BPIFB3; C20orf185; LPLUNC3",
        "gene_names_refseq": "BPIFB3; C20orf185; LPLUNC3; RYA3",
        "protein_names_uniprotkb": "BPI fold-containing family B member 3; Ligand-binding protein RYA3; Long palate, lung and nasal epithelium carcinoma-associated protein 3",
        "protein_names_refseq": "BPI fold-containing family B member 3 precursor; ligand-binding protein RYA3; long palate, lung and nasal epithelium carcinoma-associated protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:359710)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11971875;12837268;23481700;25491355;30524438",
        "class_list": "",
        "function": "May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity)., [UniProtKB]; Overexpression of BPIFB3 inhibits coxsackievirus B replication, dramatically alters the morphology of LC3B-positive vesicles, and suppresses autophagy in response to rapamycin. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TDX7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045087 innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "P59826-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14137-1",
        "uniprot_id": "BOP1_HUMAN",
        "mass": 83630.0,
        "length": 746,
        "protein_name": "Ribosome biogenesis protein BOP1",
        "gene_name": "BOP1",
        "organism": "Human",
        "refseq_name": "ribosome biogenesis protein BOP1",
        "refseq_ac": "NP_056016",
        "gene_names_uniprotkb": "BOP1; KIAA0124",
        "gene_names_refseq": "BOP1",
        "protein_names_uniprotkb": "Ribosome biogenesis protein BOP1; Block of proliferation 1 protein",
        "protein_names_refseq": "block of proliferation 1; ribosome biogenesis protein BOP1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23246);  (R-HSA-6791226)",
        "pathway_count": 2,
        "publication_count": 150,
        "publication_id_list": "11237011;11237751;11922599;12068309;12150911;12429849;12750860;16037817;16043514;16565220;16738141;16964243;17081983;17189298;17287340;17353269;17412707;18065403;18318008;18438418;18452278;18669648;18691976;18707149;18767875;19007248;19106111;19332556;19413330;19415658;19564402;19651622;19690332;19691289;19801658;20038530;20056613;20068231;20166139;20531386;20798176;20805244;20819938;21036871;21063389;21097556;21406692;22009320;22072790;22190735;22195017;22424782;22544926;22645359;22916032;23186163;23301498;23439679;23481700;23482395;2388630;24120868;24275569;24397554;24424021;24550520;24714562;24715725;25525153;25576301;25645385;25810538;25825154;25969445;26024233;26154972;26237581;26375851;26811146;26992070;27600516;27846572;27920218;28218747;28228285;28514659;28649982;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29786170;30315122;30410026;30429286;30524438;30779550;30833945;31092671;31217245;31844290;31998317;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33537174;33592498;33633747;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34229054;34357683;34405274;34509645;34932366;35051231;35154160;35561310;35580925;35705054;36010968;36241641;36284347;37217939;37615370;37681336;37938771;40307207;40914422;9482744",
        "class_list": "",
        "function": "BOP1 Promotes Prostate Cancer through the DUSP6/MAPK Pathway., [RefSeq, PubMed]; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, HAMAP, PubMed, PubMed]; PDGF-C promotes cell proliferation partially via downregulating BOP1., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q969Z6;Q96IS8;Q96Q25;Q9BSA7;Q9BVM0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0043021 ribonucleoprotein complex binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0005694 chromosome;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0008283 cell population proliferation;GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0042254 ribosome biogenesis;GO:0006364 rRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 15.3,
        "record_id": "Q14137-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q4VC05-1",
        "uniprot_id": "BCL7A_HUMAN",
        "mass": 22810.0,
        "length": 210,
        "protein_name": "B-cell CLL/lymphoma 7 protein family member A",
        "gene_name": "BCL7A",
        "organism": "Human",
        "refseq_name": "B-cell CLL/lymphoma 7 protein family member A isoform b",
        "refseq_ac": "NP_001019979",
        "gene_names_uniprotkb": "BCL7A",
        "gene_names_refseq": "BCL7A; BCL7; SMARCJ1",
        "protein_names_uniprotkb": "B-cell CLL/lymphoma 7 protein family member A",
        "protein_names_refseq": "B-cell CLL/lymphoma 7 protein family member A isoform b; B-cell CLL/lymphoma 7 protein family member A; B-cell CLL/lymphoma 7A; B-cell CLL/lymphoma-7; BCL tumor suppressor 7A; BCL7A, BAF complex component",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:605);  (R-HSA-9824585);  (R-HSA-9845323);  (R-HSA-9933937);  (R-HSA-9933939);  (R-HSA-9933946);  (R-HSA-9933947);  (R-HSA-9934037)",
        "pathway_count": 8,
        "publication_count": 63,
        "publication_id_list": "10078207;10587587;11532965;11856727;11964381;12062444;12368262;1321344;1537333;1537334;15543135;15640446;15695812;15729346;15985610;16265664;16303920;17182843;17498659;17525332;17640523;17952075;18452278;18483556;18697795;18765789;18809673;18812475;19389701;19717472;21555454;22464331;22952240;23301498;23644491;23785148;24267888;25218447;26365797;26601204;26694611;26992070;27600516;27920218;28533407;28834231;29374058;30515787;31077237;32502341;32576963;33100333;33415690;34362400;34465901;35580127;38359823;7813420;8306979;8605326;8804307;8921401;9758418",
        "class_list": "",
        "function": "BCL7A as a novel prognostic biomarker for glioma patients. Publication Status: Online-Only, [RefSeq, PubMed]; Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL., [RefSeq, PubMed]; MiR-501-3p promotes osteosarcoma cell proliferation, migration and invasion by targeting BCL7A., [RefSeq, PubMed]; Survival analysis showed that, compared with those who had higher levels of BCL7A expression, patients with ovarian cancer and low levels of BCL7A generally had shorter overall/relapse-free survival times. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DJN6;B7ZB21;Q13843;Q14CT7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0000785 chromatin",
        "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q4VC05-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q53S33-1",
        "uniprot_id": "BOLA3_HUMAN",
        "mass": 12114.0,
        "length": 107,
        "protein_name": "BolA-like protein 3",
        "gene_name": "BOLA3",
        "organism": "Human",
        "refseq_name": "bolA-like protein 3 isoform 2",
        "refseq_ac": "NP_001030582",
        "gene_names_uniprotkb": "BOLA3",
        "gene_names_refseq": "BOLA3; MMDS2",
        "protein_names_uniprotkb": "BolA-like protein 3",
        "protein_names_refseq": "bolA homolog 3; bolA-like protein 3 isoform 2; bolA-like protein 3",
        "tax_id": 9606,
        "disease": "multiple mitochondrial dysfunctions syndrome 2 (Disease Ontology:DOID:0080134)",
        "pathway": " (hsa:388962)",
        "pathway_count": 1,
        "publication_count": 35,
        "publication_id_list": "14718656;18548201;21944046;22562699;22746225;24334290;24366607;25576301;26741492;26992070;27532772;27600516;27846572;27920218;28228285;28832583;28834231;29242379;29508533;29557506;29632046;29789417;30429286;30524438;31530632;31844290;31848261;33968037;34063696;34357683;35286914;36215666;37511493;37823603;7566098",
        "class_list": "",
        "function": "Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1 (PubMed:27532772)., [UniProtKB, UniProtKB, PubMed]; BOLA-like proteins are widely conserved from prokaryotes to eukaryotes and may be involved in cell proliferation or cell-cycle regulation., [RefSeq, PubMed]; BOLA3 and NFU1 link mitoribosome iron-sulfur cluster assembly to multiple mitochondrial dysfunctions syndrome., [RefSeq, PubMed]; BOLA3 is a prognostic-related biomarker and correlated with immune infiltrates in lung adenocarcinoma., [RefSeq, PubMed]; BOLA3 plays a crucial role in the biogenesis of iron-sulfur clusters., [RefSeq, PubMed]; Molecular Basis of Multiple Mitochondrial Dysfunctions Syndrome 2 Caused by CYS59TYR BOLA3 Mutation. Publication Status: Online-Only, [RefSeq, PubMed]; Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes [case report], [RefSeq, PubMed]; This gene encodes a protein that plays an essential role in the production of iron-sulfur (Fe-S) clusters for the normal maturation of lipoate-containing 2-oxoacid dehydrogenases, and for the assembly of the mitochondrial respiratory chain complexes. Mutation in this gene has been associated with multiple mitochondrial dysfunctions syndrome-2. Two alternatively spliced transcript variants encoding different isoforms with distinct subcellular localization have been reported for this gene (PMID:21944046). [provided by RefSeq, Dec 2011]., [RefSeq]; This study reported that all three human BolA proteins (hBolA1, hBolA2, and hBolA3) are novel non-classical secreted proteins identified with bioinformatics and molecular biology experiments., [RefSeq, PubMed]; Understanding the Molecular Basis of the Multiple Mitochondrial Dysfunctions Syndrome 2: The Disease-Causing His96Arg Mutation of BOLA3. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G3XAB0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0045454 cell redox homeostasis;GO:0051604 protein maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q53S33-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5H9B9-1",
        "uniprot_id": "BM2KL_HUMAN",
        "mass": 46091.0,
        "length": 411,
        "protein_name": "Putative BMP-2-inducible kinase-like protein",
        "gene_name": "BMP2KL",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "BMP2KL",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative BMP-2-inducible kinase-like protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 3,
        "publication_id_list": "29557506;35051231;36284347",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
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        "predicted_o_glycosites": 1,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q5H9B9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5H9F3-3",
        "uniprot_id": "BCORL_HUMAN",
        "mass": 190561.0,
        "length": 1785,
        "protein_name": "BCL-6 corepressor-like protein 1",
        "gene_name": "BCORL1",
        "organism": "Human",
        "refseq_name": "BCL-6 corepressor-like protein 1 isoform 1",
        "refseq_ac": "NP_068765",
        "gene_names_uniprotkb": "BCORL1",
        "gene_names_refseq": "BCORL1; BCoR-L1; CXorf10; SHUVER",
        "protein_names_uniprotkb": "BCL-6 corepressor-like protein 1; BCoR-L1; BCoR-like protein 1",
        "protein_names_refseq": "BCL-6 corepressor-like protein 1 isoform 1; BCoR-like protein 1",
        "tax_id": 9606,
        "disease": "Shukla-Vernon syndrome (Disease Ontology:DOID:0111841); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:63035)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "16959974;17379597;17697391;18669648;21989985;23186163;23481700;23523425;24123876;25218447;25418920;25755297;26933038;27568929;27920218;28218747;28514659;28832583;29237092;29351928;29393594;29632046;30059200;30379171;30524438;30620550;30779550;30941876;31154438;31530632;32161166;32376790;32938750;33214551;34019948;34400773;35015684;35254053;35289036;35499168;36215666;37541260;38342987;38665916;39302247;39531497;39534244;40136647;41350704",
        "class_list": "",
        "function": "A hemizygous loss-of-function variant in BCORL1 is associated with male infertility and oligoasthenoteratozoospermia., [RefSeq, PubMed]; BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes., [RefSeq, PubMed]; BCORL1 by genetic criteria is a novel candidate tumor suppressor gene, joining the growing list of genes recurrently mutated in acute myelogenous leukemia., [RefSeq, PubMed]; Dysregulated BCoR-L1 expression is associated with breast cancer Erratum:[Breast Cancer Res. 2008;10(5):406], [RefSeq, PubMed]; Endometrial Stromal Sarcomas With BCOR Internal Tandem Duplication and Variant BCOR/BCORL1 Rearrangements Resemble High-grade Endometrial Stromal Sarcomas With Recurrent CDK4 Pathway Alterations and MDM2 Amplifications., [RefSeq, PubMed]; Major brain malformations: corpus callosum dysgenesis, agenesis of septum pellucidum and polymicrogyria in patients with BCORL1-related disorders., [RefSeq, PubMed]; The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]., [RefSeq]; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor., [UniProtKB, PubMed]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 7,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 24,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 24,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 24,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 58,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 31,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MDQ8;Q5H9F2;Q5H9F4;Q6ZVE0;Q8TEN3;Q9Y528",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003714 transcription corepressor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0031507 heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q5H9F3-3",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5TH69-1",
        "uniprot_id": "BIG3_HUMAN",
        "mass": 240652.0,
        "length": 2177,
        "protein_name": "Brefeldin A-inhibited guanine nucleotide-exchange protein 3",
        "gene_name": "ARFGEF3",
        "organism": "Human",
        "refseq_name": "brefeldin A-inhibited guanine nucleotide-exchange protein 3",
        "refseq_ac": "NP_065073",
        "gene_names_uniprotkb": "ARFGEF3; BIG3; C6orf92; KIAA1244",
        "gene_names_refseq": "A7322; ARFGEF3; BIG3; C6orf92; KIAA1244; PPP1R33; dJ171N11.1",
        "protein_names_uniprotkb": "Brefeldin A-inhibited guanine nucleotide-exchange protein 3; ARFGEF family member 3",
        "protein_names_refseq": "brefeldin A-inhibited guanine nucleotide-exchange protein 3; protein phosphatase 1, regulatory subunit 33",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57221)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "18691976;19496786;19664994;23186163;24997568;26853435;26992070;27397612;28218747;28228285;28555617;29493099;29557506;29786170;29789417;30429286;31154438;31421830;31844290;32157095;32387766;32938616;33968037;33981976;34087483;34171305;34363714;35051231;35580925;36010968;36241641;36284347;38253038",
        "class_list": "",
        "function": "BIG3 (ARFGEF3) is predicted to interact with its partner PHB2 through an ARM-type alpha-helical structure. Publication Status: Online-Only, [RefSeq, PubMed]; Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786)., [UniProtKB, PubMed, UniProtKB]; The survival and proliferation of osteosarcoma cells are dependent on the mitochondrial BIG3-PHB2 complex formation., [RefSeq, PubMed]; These results establish a model for the BIG3-PHB2 interaction and an entry for drug discovery for breast cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 64,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C5NM88;Q76MU8;Q8N4Y4;Q96CH9;Q96P46;Q9ULH6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0030658 transport vesicle membrane",
        "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q5TH69-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5VWW1-1",
        "uniprot_id": "C1QL3_HUMAN",
        "mass": 26719.0,
        "length": 255,
        "protein_name": "Complement C1q-like protein 3",
        "gene_name": "C1QL3",
        "organism": "Human",
        "refseq_name": "complement C1q-like protein 3 precursor",
        "refseq_ac": "NP_001010908",
        "gene_names_uniprotkb": "C1QL3; CTRP13",
        "gene_names_refseq": "C1QL3; C1QTNF13; C1ql; CTRP13; K100",
        "protein_names_uniprotkb": "Complement C1q-like protein 3; C1q and tumor necrosis factor-related protein 13; C1q/TNF-related protein 13",
        "protein_names_refseq": "C1q and tumor necrosis factor-related protein 13; C1q/TNF-related protein 13; complement C1q-like protein 3 precursor; complement C1q-like protein 3; complement component 1, q subcomponent-like 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:389941)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;21378161;28033351;28182339;31676569;32161166;35014243;37844630;37976900;38253038;38273650",
        "class_list": "",
        "function": "CTRP13 Mitigates Endothelial Cell Ferroptosis via the AMPK/KLF4 Pathway: Implications for Atherosclerosis Protection. Publication Status: Online-Only, [RefSeq, PubMed]; CTRP13 ablation improves systemic glucose and lipid metabolism., [RefSeq, PubMed]; CTRP13 alleviates palmitic acid-induced inflammation, oxidative stress, apoptosis and endothelial cell dysfunction in HUVECs., [RefSeq, PubMed]; CTRP13 is a novel adipokine that is down-regulated in the serum of type 2 diabetics., [RefSeq, PubMed]; CTRP13 preserves endothelial function in diabetic mice by regulating GCH1/BH4 axis-dependent eNOS coupling, suggesting the therapeutic potential of CTRP13 against diabetic vasculopathy., [RefSeq, PubMed]; CTRP13 reduces glucose output in hepatocytes by inhibiting the mRNA expression of gluconeogenic enzymes, glucose-6-phosphatase and the cytosolic form of phosphoenolpyruvate carboxykinase., [RefSeq, PubMed]; Decreased levels of CTRP3 and especially CTRP13 were associated with increased risk of T2DM and CAD Publication Status: Online-Only, [RefSeq, PubMed]; Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder, [RefSeq, PubMed]; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC1 and PCK1 and hence decreases de novo glucose production (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0PJY4;A0PJY5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0045202 synapse;GO:0043083 synaptic cleft;GO:0098686 hippocampal mossy fiber to CA3 synapse",
        "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0099558 maintenance of synapse structure;GO:0099550 trans-synaptic signaling, modulating synaptic transmission;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q5VWW1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5W0U4-1",
        "uniprot_id": "BSPRY_HUMAN",
        "mass": 44381.0,
        "length": 402,
        "protein_name": "B box and SPRY domain-containing protein",
        "gene_name": "BSPRY",
        "organism": "Human",
        "refseq_name": "B box and SPRY domain-containing protein isoform 1",
        "refseq_ac": "NP_001304872",
        "gene_names_uniprotkb": "BSPRY",
        "gene_names_refseq": "BSPRY",
        "protein_names_uniprotkb": "B box and SPRY domain-containing protein",
        "protein_names_refseq": "B box and SPRY domain-containing protein isoform 1; B-box and SPRY-domain containing protein; zetin 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54836)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10978534;12615066;19929093;28832583;29242379;29557506;31154438;31844290;32157095;32265295;34932366",
        "class_list": "",
        "function": "Expression analysis of the rat BSPRY ortholog and demonstration of its interaction with 14-3-3 proteins., [RefSeq, PubMed]; May regulate epithelial calcium transport by inhibiting TRPV5 activity., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KS19;Q96DJ2;Q9H4E4;Q9NXN0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0045087 innate immune response;GO:0006816 calcium ion transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q5W0U4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P575-1",
        "uniprot_id": "BGP11_HUMAN",
        "mass": 29908.0,
        "length": 273,
        "protein_name": "Putative inactive beta-glucuronidase protein GUSBP11",
        "gene_name": "GUSBP11",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "GUSBP11",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative inactive beta-glucuronidase protein GUSBP11; Beta-glucuronidase pseudogene 11",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "38253038",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds",
        "go_cellular_component": "",
        "go_biological_process": "GO:0005975 carbohydrate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q6P575-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PI77-1",
        "uniprot_id": "GASP3_HUMAN",
        "mass": 60291.0,
        "length": 547,
        "protein_name": "G protein-coupled receptor associated sorting protein 3",
        "gene_name": "GPRASP3",
        "organism": "Human",
        "refseq_name": "G protein-coupled receptor associated sorting protein 3",
        "refseq_ac": "NP_001135996",
        "gene_names_uniprotkb": "GPRASP3; BHLHB9; KIAA1701",
        "gene_names_refseq": "BHLHB9; GASP3; GPRASP3; p60TRP",
        "protein_names_uniprotkb": "G protein-coupled receptor associated sorting protein 3; Protein BHLHb9; Transcription regulator of 60 kDa; bHLHb9; p60TRP",
        "protein_names_refseq": "G protein-coupled receptor associated sorting protein 3; basic helix-loop-helix domain containing, class B, 9; basic helix-loop-helix family member b9; p60-like protein; p60-transcription-regulator-protein; protein BHLHB9; transcription regulator of 60 kDa",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80823)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "15034937;18089774;23481700;24715725;26854063;28832583;29242379;29557506;30379171;30429286;31154438;33968037;34171305;34932366;35051231;36284347",
        "class_list": "",
        "function": "Down-regulation in the brain of Alzheimer's disease subjects point to a possible pivotal role of p60TRP in the control of cellular aging and survival., [RefSeq, PubMed]; Report that some regions of p60TRP were more prone to specific mutations, with two hotspots for mutations at E15 and E171., [RefSeq, PubMed]; Survival and differentiation promoting protein that plays a role in the regulation of neurosynaptogenesis. Induces phosphatase PP2A activity which results in APP dephosphorylation and inhibits BACE1-mediated processing of APP., [UniProtKB, UniProtKB]; This gene is a member of a gene family which encodes proteins with a basic helix-loop-helix domain. Other members of this gene family encode proteins which function as transcription factors, either enhancing or inhibiting transcription depending on the activity of other DNA binding proteins. The coding region of this gene is located entirely within the terminal exon. The encoded protein may be involved in the survival of neurons (PMID: 15034937). Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9C0G2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0007611 learning or memory;GO:0043524 negative regulation of neuron apoptotic process;GO:0051965 positive regulation of synapse assembly;GO:0061003 positive regulation of dendritic spine morphogenesis;GO:0050769 positive regulation of neurogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q6PI77-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6RI45-1",
        "uniprot_id": "BRWD3_HUMAN",
        "mass": 203598.0,
        "length": 1802,
        "protein_name": "Bromodomain and WD repeat-containing protein 3",
        "gene_name": "BRWD3",
        "organism": "Human",
        "refseq_name": "bromodomain and WD repeat-containing protein 3 isoform X2",
        "refseq_ac": "XP_016884873",
        "gene_names_uniprotkb": "BRWD3",
        "gene_names_refseq": "BRODL; BRWD3; DCAF20; MRX93; XLID93",
        "protein_names_uniprotkb": "Bromodomain and WD repeat-containing protein 3",
        "protein_names_refseq": "bromodomain and WD repeat-containing protein 3 isoform X2",
        "tax_id": 9606,
        "disease": "non-syndromic X-linked intellectual disability 93 (Disease Ontology:DOID:0112045)",
        "pathway": " (hsa:254065)",
        "pathway_count": 1,
        "publication_count": 50,
        "publication_id_list": "10.1101/2023.09.13.557529;15543602;17668385;20068231;21406692;21834987;23186163;23481700;25892735;28218747;28228285;28514659;28649982;28832583;28904123;29242379;29393594;29437277;29632046;29632711;29769354;29786170;30192525;30315122;30379171;30410026;31844290;32157095;32357974;32387766;32488085;32502341;32938616;33298915;33392160;33592498;33912179;33968037;33981976;34019948;34087483;34171305;34561969;35051231;35494241;36010968;36215666;36241641;36284347;37217939",
        "class_list": "",
        "function": "Required for regulation of cell morphology and cytoskeletal organization., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
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        "reported_snv": 49,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9IZ39;C9J3F3;Q2T9J6;Q5JRN1;Q6RI37;Q6RI42;Q6RI44;Q8N916",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007010 cytoskeleton organization;GO:0008360 regulation of cell shape",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q6RI45-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZSU1-1",
        "uniprot_id": "C2G1P_HUMAN",
        "mass": 16683.0,
        "length": 146,
        "protein_name": "Putative inactive cytochrome P450 2G1",
        "gene_name": "CYP2G1P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "CYP2G1P; CYP2GP1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative inactive cytochrome P450 2G1; Cytochrome P450 2G1 pseudogene",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "restrictive dermopathy (Disease Ontology:DOID:0060762); polycystic ovary syndrome (Disease Ontology:DOID:11612)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "11186129",
        "class_list": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q6ZSU1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z5L3-1",
        "uniprot_id": "C1QL2_HUMAN",
        "mass": 29468.0,
        "length": 287,
        "protein_name": "Complement C1q-like protein 2",
        "gene_name": "C1QL2",
        "organism": "Human",
        "refseq_name": "complement C1q-like protein 2 precursor",
        "refseq_ac": "NP_872334",
        "gene_names_uniprotkb": "C1QL2; CTRP10",
        "gene_names_refseq": "C1QL2; C1QTNF10; CTRP10",
        "protein_names_uniprotkb": "Complement C1q-like protein 2; C1q and tumor necrosis factor-related protein 10; C1q/TNF-related protein 10",
        "protein_names_refseq": "C1q and tumor necrosis factor-related protein 10; C1q-domain containing protein; C1q/TNF-related protein 10; complement C1q-like protein 2 precursor; complement C1q-like protein 2; complement component 1, q subcomponent-like 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:165257)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "20237496;36241641",
        "class_list": "",
        "function": "May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity)., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0043083 synaptic cleft;GO:0032991 protein-containing complex;GO:0098686 hippocampal mossy fiber to CA3 synapse",
        "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0099558 maintenance of synapse structure;GO:0090128 regulation of synapse maturation;GO:0099550 trans-synaptic signaling, modulating synaptic transmission;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q7Z5L3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z5Y6-1",
        "uniprot_id": "BMP8A_HUMAN",
        "mass": 44798.0,
        "length": 402,
        "protein_name": "Bone morphogenetic protein 8A",
        "gene_name": "BMP8A",
        "organism": "Human",
        "refseq_name": "bone morphogenetic protein 8A preproprotein",
        "refseq_ac": "NP_861525",
        "gene_names_uniprotkb": "BMP8A",
        "gene_names_refseq": "BMP8A; OP-2; Op2",
        "protein_names_uniprotkb": "Bone morphogenetic protein 8A; BMP-8A",
        "protein_names_refseq": "BMP-8A; bone morphogenetic protein 8A preproprotein",
        "tax_id": 9606,
        "disease": "diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:353500)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "22579288;29557506;31656161;31940275;32128917;33338549;36594156",
        "class_list": "",
        "function": "Bone morphogenetic protein 8A (BMP8) is highly expressed in clear cell renal cell carcinoma (ccRCC) suggesting a poor prognosis of ccRCC. BMP8 activates Nrf2 regulated reactive oxygen balance, and by regulating the transcription level of TRIM24, it is involved in the regulation of the Wnt pathway to promote the proliferation, invasion and metastasis of ccRCC and the resistance of As2O3., [RefSeq, PubMed]; Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance (PubMed:22579288, PubMed:31940275). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:31940275). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway (PubMed:31940275)., [UniProtKB, PubMed, PubMed]; Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway., [RefSeq, PubMed]; Human bone morphogenetic protein 8A promotes expansion and prevents apoptosis of cumulus cells in vitro., [RefSeq, PubMed]; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT., [UniProtKB, PubMed]; Recent progress in the biology and physiology of BMP-8a. Review article, [RefSeq, PubMed]; Serous BMP8A has Clinical Significance in the Ultrasonic Diagnosis of Thyroid Cancer and Promotes Thyroid Cancer Cell Progression., [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "Q5T3A5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0030154 cell differentiation;GO:0097009 energy homeostasis;GO:0046676 negative regulation of insulin secretion;GO:0030509 BMP signaling pathway;GO:0002024 diet induced thermogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q7Z5Y6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IYA2-1",
        "uniprot_id": "C144C_HUMAN",
        "mass": 143112.0,
        "length": 1237,
        "protein_name": "Putative coiled-coil domain-containing protein 144C",
        "gene_name": "CCDC144CP",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "CCDC144CP; CCDC144C",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative coiled-coil domain-containing protein 144C; Coiled-coil domain-containing protein 144C pseudogene",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "22424782;30379171",
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        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "B7WNP5",
        "ec_number_list": "",
        "go_molecular_function": "",
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        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8IYA2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N4F0-1",
        "uniprot_id": "BPIB2_HUMAN",
        "mass": 49172.0,
        "length": 458,
        "protein_name": "BPI fold-containing family B member 2",
        "gene_name": "BPIFB2",
        "organism": "Human",
        "refseq_name": "BPI fold-containing family B member 2 precursor",
        "refseq_ac": "NP_079503",
        "gene_names_uniprotkb": "BPIFB2; BPIL1; C20orf184; LPLUNC2; PRO5776",
        "gene_names_refseq": "BPIFB2; BPIL1; C20orf184; LPLUNC2; RYSR; dJ726C3.2",
        "protein_names_uniprotkb": "BPI fold-containing family B member 2; BPI-like 1; Bactericidal/permeability-increasing protein-like 1; Long palate, lung and nasal epithelium carcinoma-associated protein 2; RYSR",
        "protein_names_refseq": "BPI fold-containing family B member 2 precursor; BPI-like 1; bactericidal/permeability-increasing protein-like 1; long palate, lung and nasal epithelium carcinoma-associated protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80341);  (R-HSA-381426);  (R-HSA-6803157);  (R-HSA-8957275)",
        "pathway_count": 4,
        "publication_count": 134,
        "publication_id_list": "10026136;10077652;10218588;10512690;10614670;10681634;10810289;10898936;10912521;10951195;10990447;11120840;11158056;11250653;11264294;11313366;11316783;11389039;11522292;11606061;11739083;11751371;11788658;11971875;12185532;12241545;12379487;12466191;12493837;12810533;12837268;12904166;12975309;1370451;13816;1383255;14506276;14739326;15126567;1522221;15229136;15308688;15340161;15469690;15485880;15525596;15642270;15778384;15826377;15956276;16054449;16215847;16336202;16354652;16354654;16374474;16740002;16799473;16931762;16940129;16959974;17047378;17249697;17312271;17363965;17502600;17567961;17964057;17985932;18021746;18160480;18185531;18673279;19095652;19179970;19254208;19818633;20103720;20180804;20237496;20382864;20395631;20510021;20845358;21787330;22262861;22327069;22455996;22701042;23090970;23302724;23426625;24190977;24219363;24256734;24715725;2476804;2479552;25075772;25461571;25596890;26091039;26148048;27089320;29557506;30779550;3286634;33592498;33912179;35051231;35240266;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;8781553;8817670;8894645;8964575;9497324;9523110;9665269;9709957;9733769;9756476;9786878;9922210",
        "class_list": "",
        "function": "BPIFB2 is highly expressed in ''cold'' lung adenocarcinoma and decreases T cell chemotaxis via activation of the STAT3 pathway., [RefSeq, PubMed]; BPIL1 maps to Chromosome 20q11; thus, these novel genes form a cluster with BPI and two other members of the LT/LBP gene family on the long arm of human Chr 20. AA sequence is reported., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a member of the lipid transfer/lipopolysaccharide binding protein (LT/LBP) gene family. It is highly expressed in hypertrophic tonsils. This gene and three other members of the LT/LBP gene family form a cluster on the long arm of chromosome 20. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
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        "reported_n_glycosites": 3,
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        "total_reported_n_glycosites": 3,
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        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
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        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6UWN3;Q6ZME0;Q8NFQ7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005788 endoplasmic reticulum lumen;GO:0070062 extracellular exosome",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 13.8,
        "record_id": "Q8N4F0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NFJ8-1",
        "uniprot_id": "BHE22_HUMAN",
        "mass": 36997.0,
        "length": 381,
        "protein_name": "Class E basic helix-loop-helix protein 22",
        "gene_name": "BHLHE22",
        "organism": "Human",
        "refseq_name": "class E basic helix-loop-helix protein 22",
        "refseq_ac": "NP_689627",
        "gene_names_uniprotkb": "BHLHE22; BHLHB5; TNRC20",
        "gene_names_refseq": "BHLHB5; BHLHE22; Beta3a; Beta3; CAGL85; TNRC20",
        "protein_names_uniprotkb": "Class E basic helix-loop-helix protein 22; Class B basic helix-loop-helix protein 5; Trinucleotide repeat-containing gene 20 protein; bHLHb5; bHLHe22",
        "protein_names_refseq": "basic helix-loop-helix domain containing, class B, 5; class B basic helix-loop-helix protein 5; class E basic helix-loop-helix protein 22; trinucleotide repeat containing 20",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27319);  (R-HSA-9762293)",
        "pathway_count": 2,
        "publication_count": 22,
        "publication_id_list": "12213201;14516699;15699330;16793922;22227038;24130169;24810778;26992070;29269046;29296180;29642003;31844290;32387766;32463580;33717175;34509645;34664540;35051231;35806162;36010968;36941015;39894887",
        "class_list": "",
        "function": "BHLHE22 Expression Is Associated with a Proinflammatory Immune Microenvironment and Confers a Favorable Prognosis in Endometrial Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; BHLHE22 drives the immunosuppressive bone tumor microenvironment and associated bone metastasis in prostate cancer., [RefSeq, PubMed]; Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal cord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation., [UniProtKB, UniProtKB]; Rare variant association study of veteran twin whole-genomes links severe depression with a nonsynonymous change in the neuronal gene BHLHE22., [RefSeq, PubMed]; Segregates with Duane syndrome.  Brain-specific expression with the highest abundance in the cerebellum., [RefSeq, PubMed]; This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. A similar protein in mouse is required for the development of the dorsal cochlear nuclei, and is thought to play a role in in the differentiation of neurons involved in sensory input. The mouse protein also functions in retinogenesis. [provided by RefSeq, Oct 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0061564 axon development;GO:0007423 sensory organ development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q8NFJ8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NFQ6-1",
        "uniprot_id": "BPIFC_HUMAN",
        "mass": 56469.0,
        "length": 507,
        "protein_name": "BPI fold-containing family C protein",
        "gene_name": "BPIFC",
        "organism": "Human",
        "refseq_name": "BPI fold-containing family C protein precursor",
        "refseq_ac": "NP_777592",
        "gene_names_uniprotkb": "BPIFC; BPIL2",
        "gene_names_refseq": "BPIFC; BPIL2",
        "protein_names_uniprotkb": "BPI fold-containing family C protein; BPI-like 2; Bactericidal/permeability-increasing protein-like 2",
        "protein_names_refseq": "BPI fold-containing family C protein precursor; BPI fold-containing family C protein; BPI-like 2; bactericidal/permeability-increasing protein-like 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:254240)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12185532;18477386;26768311;29557506;31033252;31844290;33392160;35051231;38474063",
        "class_list": "",
        "function": "BPIFC c.3G>C mutation segregates with hereditary trichilemmal cysts in a large Chinese family., [RefSeq, PubMed]; BPIL2maps to Chr 22q13. AA sequence is reported., [RefSeq, PubMed]; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope., [UniProtKB, UniProtKB, UniProtKB]; Transcriptomic Analyses and Experimental Validation Identified Immune-Related lncRNA-mRNA Pair MIR210HG-BPIFC Regulating the Progression of Hypertrophic Cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 9,
        "predicted_n_glycosites": 9,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 9859,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RRF1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005543 phospholipid binding;GO:0001530 lipopolysaccharide binding;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q8NFQ6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TDL5-1",
        "uniprot_id": "BPIB1_HUMAN",
        "mass": 52442.0,
        "length": 484,
        "protein_name": "BPI fold-containing family B member 1",
        "gene_name": "BPIFB1",
        "organism": "Human",
        "refseq_name": "BPI fold-containing family B member 1 precursor",
        "refseq_ac": "NP_149974",
        "gene_names_uniprotkb": "BPIFB1; C20orf114; LPLUNC1; PRO1357",
        "gene_names_refseq": "BPIFB1; C20orf114; LPLUNC1",
        "protein_names_uniprotkb": "BPI fold-containing family B member 1; Long palate, lung and nasal epithelium carcinoma-associated protein 1; VEMSGP; von Ebner minor salivary gland protein",
        "protein_names_refseq": "BPI fold-containing family B member 1 precursor; VEMSGP; long palate, lung and nasal epithelium carcinoma associated 1; long palate, lung and nasal epithelium carcinoma-associated protein 1; von Ebner minor salivary gland protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92747);  (R-HSA-6803157)",
        "pathway_count": 2,
        "publication_count": 80,
        "publication_id_list": "11120840;11237011;11313366;11389039;11971875;12493837;12874788;12975309;13816;14506276;14739326;1522221;15229136;15778384;15826377;15956276;16054449;16215847;16336202;16354652;16354654;16374474;16799473;16931762;16940129;17363965;17502600;17567961;17964057;18021746;18160480;18185531;18673279;19095652;19179970;19254208;19818633;20103720;20180804;20382864;20395631;20510021;20845358;21787330;21900486;22262861;22327069;22455996;22701042;23090970;23302724;23426625;24190977;24219363;24256734;25075772;25461571;25596890;26148048;26154972;26375851;26811146;27089320;27452731;29123267;29296079;29557506;29568064;29741879;30886235;31154438;3286634;32938616;34171305;35051231;35494241;37847709;9523110;9665269;9756476",
        "class_list": "",
        "function": "A novel mechanism underlying the anticancer effect of LPLUNC1 and clarifying that PHB1 may represent a novel, promising candidate tumour suppressor gene in Nasopharyngeal carcinoma, with potential therapeutic target value., [RefSeq, PubMed]; BPIFA1 and BPIFB1 expressions are correlated with goblet cell metaplasia and inversely correlated with lung function parameters of airway obstruction (FEV1 and FEV1/FVC) in COPD patients. Publication Status: Online-Only, [RefSeq, PubMed]; BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance., [RefSeq, PubMed]; BPIFB1 negatively regulates its interactor VTN, thereby inhibiting VTN-induced proliferation, antiapoptotic effects, G2/M phase arrest, DSB repair, and the activation of the ATM-Chk2 and ATR-Chk1 pathways after irradiation. Publication Status: Online-Only, [RefSeq, PubMed]; LPLUNC1 is found to be down-expressed in 33 of 48 nasopharyngeal carcinoma biopsies., [RefSeq, PubMed]; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS., [UniProtKB, PubMed]; Results showed that BPIFB1 expression markedly inhibited NPC cell migration, invasion, and lung-metastatic abilities. Additionally, identification of two BPIFB1-interacting proteins, VTN and VIM, showed that BPIFB1 reduced VTN expression and the formation of a VTN-integrin alphaV complex in NPC cells, leading to inhibition of the FAK/Src/ERK signalling pathway., [RefSeq, PubMed]; The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 8836,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2H8;Q5QP43;Q6UWY1;Q6ZRU7;Q96HK6;Q9BQP8;Q9BWZ6;Q9H4V6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0070062 extracellular exosome;GO:0005615 extracellular space",
        "go_biological_process": "GO:0002227 innate immune response in mucosa;GO:0034144 negative regulation of toll-like receptor 4 signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "Q8TDL5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WY22-1",
        "uniprot_id": "BRI3B_HUMAN",
        "mass": 27836.0,
        "length": 251,
        "protein_name": "BRI3-binding protein",
        "gene_name": "BRI3BP",
        "organism": "Human",
        "refseq_name": "BRI3-binding protein precursor",
        "refseq_ac": "NP_542193",
        "gene_names_uniprotkb": "BRI3BP; KG19",
        "gene_names_refseq": "BNAS1; BRI3BP; HCCR-1; HCCR-2; HCCRBP-1; HCCRBP-3; KG19",
        "protein_names_uniprotkb": "BRI3-binding protein; Cervical cancer 1 proto-oncogene-binding protein KG19; HCCRBP-1; I3-binding protein",
        "protein_names_refseq": "BRI3-binding protein precursor; I3-binding protein; cervical cancer 1 proto-oncogene-binding protein KG19; cervical cancer oncogene binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:140707)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "11237011;11860200;17765869;17943721;18578522;19608861;20068231;22851403;23186163;23481700;24715725;25576301;26154972;28904123;29242379;29393594;29437277;29557506;29632046;30410026;30983867;31611695;31844290;31937595;31998317;32265295;32387766;32938616;33141586;33298915;33912179;34171305;36010968;36241641",
        "class_list": "",
        "function": "HCCRBP-3 induces tumorigenesis through direct interaction with HCCR-1 in human cancers., [RefSeq, PubMed]; Highly expressed in brain, kidney, and liver; mapped to human chromosome 12q24.2-qter, [RefSeq, PubMed]; Involved in tumorigenesis and may function by stabilizing p53/TP53., [UniProtKB, PubMed]; Taken together, BRI3BP, widely expressed in animal cell types, seems to possess a pro-apoptotic property and can potentiate drug-induced apoptosis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WY23",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q8WY22-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96A19-1",
        "uniprot_id": "C102A_HUMAN",
        "mass": 62596.0,
        "length": 550,
        "protein_name": "Coiled-coil domain-containing protein 102A",
        "gene_name": "CCDC102A",
        "organism": "Human",
        "refseq_name": "coiled-coil domain-containing protein 102A",
        "refseq_ac": "NP_149989",
        "gene_names_uniprotkb": "CCDC102A",
        "gene_names_refseq": "CCDC102A",
        "protein_names_uniprotkb": "Coiled-coil domain-containing protein 102A",
        "protein_names_refseq": "coiled-coil domain-containing protein 102A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92922)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "18669648;20068231;23186163;24275569;25576301;26992070;27920218;28832583;29242379;29557506;30379171;30429286;31844290;32897882;32938616;32983136;33968037;34171305;35580925",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BT74",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016459 myosin complex",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q96A19-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96B45-1",
        "uniprot_id": "BORC7_HUMAN",
        "mass": 11695.0,
        "length": 106,
        "protein_name": "BLOC-1-related complex subunit 7",
        "gene_name": "BORCS7",
        "organism": "Human",
        "refseq_name": "BLOC-1-related complex subunit 7",
        "refseq_ac": "NP_001129672",
        "gene_names_uniprotkb": "BORCS7; C10orf32",
        "gene_names_refseq": "BORCS7; C10orf32",
        "protein_names_uniprotkb": "BLOC-1-related complex subunit 7; Diaskedin",
        "protein_names_refseq": "BLOC-1-related complex subunit 7; UPF0693 protein C10orf32; diaskedin",
        "tax_id": 9606,
        "disease": "neuroaxonal dystrophy (Disease Ontology:DOID:2367); hereditary spastic paraplegia (Disease Ontology:DOID:2476)",
        "pathway": " (hsa:119032)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "18669648;19413330;25892735;25898167;27158905;27397612;27692299;27862975;29557506;30833945;31154438;31386983;31844290;32157095;32897882;32938616;32983136;34171305;34509645;35051231;35318648;36010968;36241641;36284347;36581221;36717601;37217939",
        "class_list": "",
        "function": "As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor., [UniProtKB, PubMed]; BORC complex specific components and Kinesin-1 mediate autophagy evasion by the autophagy-resistant Mycobacterium tuberculosis Beijing strain. Publication Status: Online-Only, [RefSeq, PubMed]; Effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: a PET imaging study, [RefSeq, PubMed]; Risk alleles spanning multiple genes across the 10q24.32 schizophrenia-related locus are associated in the human brain selectively with an increase in the expression of both BLOC-1 related complex subunit 7 (BORCS7) and a previously uncharacterized, human-specific arsenite methyltransferase (AS3MT) isoform (AS3MTd2d3)., [RefSeq, PubMed]; Sngle nucleotide polymorphism in c10orf32 gene is associated with skin lesions., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "secondary_ac_list": "B2R488;B3KUW4;C9K0X3",
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0098574 cytoplasmic side of lysosomal membrane;GO:0099078 BORC complex",
        "go_biological_process": "GO:0051036 regulation of endosome size;GO:0032418 lysosome localization;GO:0072384 organelle transport along microtubule;GO:0062196 regulation of lysosome size",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q96B45-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96KE9-3",
        "uniprot_id": "BTBD6_HUMAN",
        "mass": 58776.0,
        "length": 538,
        "protein_name": "BTB/POZ domain-containing protein 6",
        "gene_name": "BTBD6",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing protein 6 isoform 1",
        "refseq_ac": "NP_150374",
        "gene_names_uniprotkb": "BTBD6; BDPL",
        "gene_names_refseq": "BDPL; BTBD6",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein 6; Lens BTB domain protein",
        "protein_names_refseq": "BTB (POZ) domain containing 6; BTB domain protein BDPL; BTB/POZ domain-containing protein 6 isoform 1; BTB/POZ domain-containing protein 6; epididymis secretory sperm binding protein; glucocorticoid receptor AF-1 coactivator-1; lens BTB domain protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:90135);  (R-HSA-8951664);  (R-HSA-983168)",
        "pathway_count": 3,
        "publication_count": 140,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11062501;11069780;11259415;11292861;11292862;11350924;11454738;11585840;11733065;11961546;12101228;12107413;12186903;12504025;12504026;12526791;12538644;12609982;12646216;12682069;12759363;12816948;14690597;14734113;14757770;15224091;15224092;15282312;15361859;15367669;15537541;15571818;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16595681;16647857;16707496;16790436;16849449;16943200;16954532;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18662542;18775313;18776931;18805092;18826954;18851830;18926707;19028597;19250909;19321346;19352404;19452197;19489725;19617556;19748355;19851334;19874575;19940261;20080956;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;2261476;22959436;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24366543;24636985;24793695;24793696;25314029;25349211;25355947;25531226;26344709;26460955;26632597;26906416;27030794;27222660;27565346;28115426;28228285;28832583;29153394;29242379;29393594;29632046;29769354;30315122;30610225;30779550;31154438;31848261;32005965;32284348;33444648;9380723;9668046;9790970;9887101;9891082",
        "class_list": "",
        "function": "Adapter protein for the cul3 E3 ubiquitin-protein ligase complex (By similarity). Involved in late neuronal development and muscle formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Btbd6a promotes the relocation of Plzf from nucleus to cytoplasm and targets Plzf for ubiquitination and degradation, [RefSeq, PubMed]",
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        "secondary_ac_list": "Q8IVQ7;Q9BR94",
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0022008 neurogenesis",
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        "record_id": "Q96KE9-3",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BQP9-1",
        "uniprot_id": "BPIA3_HUMAN",
        "mass": 28436.0,
        "length": 254,
        "protein_name": "BPI fold-containing family A member 3",
        "gene_name": "BPIFA3",
        "organism": "Human",
        "refseq_name": "BPI fold-containing family A member 3 isoform 2 precursor",
        "refseq_ac": "NP_001035904",
        "gene_names_uniprotkb": "BPIFA3; C20orf71; SPLUNC3",
        "gene_names_refseq": "BPIFA3; C20orf71; SPLUNC3",
        "protein_names_uniprotkb": "BPI fold-containing family A member 3; Short palate, lung and nasal epithelium carcinoma-associated protein 3",
        "protein_names_refseq": "BPI fold-containing family A member 3 isoform 2 precursor; short long palate, lung and nasal epithelium carcinoma associated 3",
        "tax_id": 9606,
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        "pathway": " (hsa:128861)",
        "pathway_count": 1,
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        "secondary_ac_list": "Q5JWG8;Q6NZ38",
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        "go_molecular_function": "GO:0008289 lipid binding",
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        "record_id": "Q9BQP9-1",
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    },
    {
        "uniprot_canonical_ac": "Q9H3Q1-1",
        "uniprot_id": "BORG4_HUMAN",
        "mass": 37980.0,
        "length": 356,
        "protein_name": "Cdc42 effector protein 4",
        "gene_name": "CDC42EP4",
        "organism": "Human",
        "refseq_name": "cdc42 effector protein 4",
        "refseq_ac": "NP_036253",
        "gene_names_uniprotkb": "CDC42EP4; BORG4; CEP4",
        "gene_names_refseq": "BORG4; CDC42EP4; CEP4; KAIA1777",
        "protein_names_uniprotkb": "Cdc42 effector protein 4; Binder of Rho GTPases 4",
        "protein_names_refseq": "CDC42 effector protein (Rho GTPase binding) 4; binder of Rho GTPases 4; cdc42 effector protein 4",
        "tax_id": 9606,
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        "pathway": " (hsa:23580);  (R-HSA-9013148);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013406)",
        "pathway_count": 5,
        "publication_count": 341,
        "publication_id_list": "10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10699171;10699464;10724160;10847683;10873802;10958683;10967094;11007481;11035016;11058585;11085924;11145705;11149925;11185749;11237011;11306516;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11696321;11704860;11707441;11756552;11773441;11803464;11804587;11804589;11804590;11884391;11912491;11919634;11948177;11961559;12071859;12093360;12096337;12172552;12195014;12221096;12242347;12351724;12432077;12456725;12464619;12531887;12546821;12547822;12650940;12665586;12773384;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;1464587;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15147912;15157669;15169870;15260990;15302923;15304341;15339924;15342493;15485661;15507211;15542837;15546864;15579468;15601624;15611138;15728722;15814684;15850391;15858067;15897194;16002401;16081809;16112081;16116428;16184169;16217026;16243035;16243036;16473593;16492808;16507994;16519628;1660188;16630611;16636067;16702231;16714282;16762923;16777452;16777849;16862148;16896804;16914516;16964243;16968698;17060455;17064668;17077126;17081983;17145773;17158234;17196961;17214551;17244649;17269730;17583407;17599059;17698854;17702745;17765681;17804252;17924679;17932950;17976533;18006505;18045877;18056264;18191593;18212344;18218625;18249095;18347018;18363964;18396277;18426980;18452278;18653540;18662984;18669648;18691976;18786931;18835169;18838382;18929667;19258391;19269969;19413330;19494238;19605563;19651622;19664994;19673492;19713215;19934221;20068231;20400958;20460433;20679435;20810653;21148482;21151158;21378159;21454492;21542010;21565175;21613211;21685891;21730051;21865595;21989057;22004470;22096251;22298643;22407364;22461490;22475431;22571869;22608513;22734669;22970203;23186163;23200924;23209303;23255595;23288169;23406282;23434736;23555621;23572525;23707487;23718289;23757206;23870057;23940355;24086303;24129315;24259668;24275569;24297911;24335996;24352656;24355937;24584464;24623723;24859002;24933155;24960694;24996924;25024229;25086031;25211221;25428919;25576301;25678704;25704760;25721503;25795300;25862245;25963737;25981171;26016997;26129894;26299518;26375851;26529257;26598554;26887924;26992070;27096001;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27798618;27806292;27846572;27862975;27913681;28028151;28114311;28196833;28825699;28860633;28904123;29089502;29358323;29382922;29393594;29508533;29557506;29789417;30061681;30192525;30379171;30429286;30853411;31154438;31389670;31844290;31848261;31871319;31998317;32157095;32203420;32387766;32938616;33912179;33968037;34087483;35051231;35580925;36284347;38153517;40596516;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8643598;8645157;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8810315;8816443;8939998;8990121;8994827;9013646;9099726;9113980;9268338;9305890;9405671;9438849;9490638;9497316;9582072;9659915;9670022;9705280;9792683;9822598;9829970;9843499;9846874;9857026;9988689",
        "class_list": "",
        "function": "Cell division cycle 42 effector protein 4 inhibits prostate cancer progression by suppressing ERK signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts., [UniProtKB]; Studies indicate some of the functional and mechanistic roles of the binder of Rho GTPases Borg1-5 proteins (Cdc42EP1-5), including cytoskeletal remodelling and signalling. Review article, [RefSeq, PubMed]; The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]., [RefSeq]; This study showed that CDC42EP4 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "total_reported_n_glycosites": 0,
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        "reported_phosphosites": 17,
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        "secondary_ac_list": "B3KUS7;O95828;Q96FT3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction",
        "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0031274 positive regulation of pseudopodium assembly;GO:0030838 positive regulation of actin filament polymerization",
        "synthesized_glycan_count": 0,
        "hit_score": 34.4,
        "record_id": "Q9H3Q1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HBH7-1",
        "uniprot_id": "BEX1_HUMAN",
        "mass": 14860.0,
        "length": 125,
        "protein_name": "Protein BEX1",
        "gene_name": "BEX1",
        "organism": "Human",
        "refseq_name": "protein BEX1",
        "refseq_ac": "NP_060946",
        "gene_names_uniprotkb": "BEX1",
        "gene_names_refseq": "BEX1; BEX2; HBEX2; HGR74-h",
        "protein_names_uniprotkb": "Protein BEX1; Brain-expressed X-linked protein 1",
        "protein_names_refseq": "brain-expressed X-linked protein 1; ovarian granulosa cell 13.0 kDa protein hGR74; protein BEX1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55859)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "10931946;11989783;15920485;15958283;16498402;26992070;28832583;29242379;29557506;30429286;33592498;33745298;33981976;34171305;34217777;34576008;37209973;37715024",
        "class_list": "",
        "function": "BEX1 Is Differentially Expressed in Aldosterone-Producing Adenomas and Protects Human Adrenocortical Cells From Ferroptosis., [RefSeq, PubMed]; BEX1 and BEX4 Induce GBM Progression through Regulation of Actin Polymerization and Activation of YAP/TAZ Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; BEX1 mediates sorafenib resistance in hepatocellular carcinoma by regulating AKT signaling., [RefSeq, PubMed]; BEX1 supports the stemness of hepatoblastoma by facilitating Warburg effect in a PPARgamma/PDK1 dependent manner., [RefSeq, PubMed]; DNMT1-mediated methylation of BEX1 regulates stemness and tumorigenicity in liver cancer., [RefSeq, PubMed]; Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This new human gene is mapped to the X chromosome and has an expression pattern of a spermatogenesis-related gene., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVN1;A8K4J3;Q9NZ33",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0035591 signaling adaptor activity;GO:0001223 transcription coactivator binding;GO:0140678 molecular function inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0031397 negative regulation of protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q9HBH7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NPI1-1",
        "uniprot_id": "BRD7_HUMAN",
        "mass": 74139.0,
        "length": 651,
        "protein_name": "Bromodomain-containing protein 7",
        "gene_name": "BRD7",
        "organism": "Human",
        "refseq_name": "bromodomain-containing protein 7 isoform 1",
        "refseq_ac": "NP_001167455",
        "gene_names_uniprotkb": "BRD7; BP75; CELTIX1",
        "gene_names_refseq": "BP75; BRD7; CELTIX1; NAG4; SMARCI1",
        "protein_names_uniprotkb": "Bromodomain-containing protein 7; 75 kDa bromodomain protein; Protein CELTIX-1",
        "protein_names_refseq": "75 kDa bromodomain protein; bromodomain-containing protein 7 isoform 1; protein CELTIX-1",
        "tax_id": 9606,
        "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); alcohol use disorder (Disease Ontology:DOID:1574); ovary epithelial cancer (Disease Ontology:DOID:2152); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); acute myeloid leukemia (Disease Ontology:DOID:9119)",
        "pathway": " (hsa:29117);  (R-HSA-6804758);  (R-HSA-9933939)",
        "pathway_count": 3,
        "publication_count": 76,
        "publication_id_list": "10078207;11025449;11099047;11237011;12489984;15640446;15985610;16265664;16475162;16839880;17081983;17498659;18452278;18794358;18809673;19367720;20068231;20215511;20228809;20660729;21406692;22464331;23186163;23301498;23431171;24275569;25576301;25593309;25755297;25880248;26365797;26375851;26758079;27846572;27862975;27920218;28218747;28228285;28832583;28904123;29242379;29393594;29437277;29632046;29786170;30315122;30429286;30833945;31154438;31217245;31530632;31844290;32157095;32265295;32357974;32387766;32938616;32983136;33101843;33298915;33592498;33912179;33981976;34171305;34185709;34465901;34509645;35051231;35580925;36010968;36477655;36484504;36788209;37365429;39222175;8804307",
        "class_list": "",
        "function": "Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Characterization of the Functional Interplay between the BRD7 and BRD9 Homologues in mSWI/SNF Complexes., [RefSeq, PubMed]; Identification of BRD7 by whole-exome sequencing as a predictor for intermediate-stage hepatocellular carcinoma in patients undergoing TACE., [RefSeq, PubMed]; LncRNA LENGA acts as a tumor suppressor in gastric cancer through BRD7/TP53 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM28 promotes tumor growth and metastasis in breast cancer by targeting the BRD7 protein for ubiquitination and degradation., [RefSeq, PubMed]; This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VC09;Q8N2L9;Q96KA4;Q9BV48;Q9UH59",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0000976 transcription cis-regulatory region binding;GO:0042393 histone binding;GO:0002039 p53 binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:0000776 kinetochore",
        "go_biological_process": "GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0007346 regulation of mitotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "Q9NPI1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NPY3-1",
        "uniprot_id": "C1QR1_HUMAN",
        "mass": 68560.0,
        "length": 652,
        "protein_name": "Complement component C1q receptor",
        "gene_name": "CD93",
        "organism": "Human",
        "refseq_name": "complement component C1q receptor precursor",
        "refseq_ac": "NP_036204",
        "gene_names_uniprotkb": "CD93; C1QR1; MXRA4",
        "gene_names_refseq": "C1QR1; C1qR(P); C1qRP; CD93; CDw93; ECSM3; MXRA4; dJ737E23.1",
        "protein_names_uniprotkb": "Complement component C1q receptor; C1q/MBL/SPA receptor; C1qR(p); C1qRp; C1qR; CDw93; Complement component 1 q subcomponent receptor 1; Matrix-remodeling-associated protein 4",
        "protein_names_refseq": "C1q receptor 1; C1q/MBL/SPA receptor; C1qR; CD93 antigen; complement component 1 q subcomponent receptor 1; complement component C1q receptor precursor; complement component C1q receptor; matrix-remodeling-associated protein 4; matrix-remodelling associated 4",
        "tax_id": 9606,
        "disease": "thyroid gland carcinoma (Disease Ontology:DOID:3963)",
        "pathway": " (hsa:22918);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 32,
        "publication_id_list": "10092817;11086025;11781389;11994479;16959974;18083107;23650620;24809468;26848865;28671670;29242379;29393594;29557506;30459171;32157095;32350084;32387766;34357683;34411563;35051231;35251023;36265539;38218180;38224815;38250037;38511888;39190192;39467677;7977768;8692836;9047234;9233640",
        "class_list": "glycogene",
        "function": "Blockade of CD93 in pleural mesothelial cells fuels anti-lung tumor immune responses. Publication Status: Online-Only, [RefSeq, PubMed]; CD93 regulates breast cancer growth and vasculogenic mimicry through the PI3K/AKT/SP2 signaling pathway activated by integrin beta1., [RefSeq, PubMed]; Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2) (PubMed:7977768). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis (PubMed:24809468). Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration (PubMed:26848865). Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands (PubMed:28671670, PubMed:36265539, PubMed:38218180). Both ligands play a non-redundant role in CD93-mediated endothelial cell function (PubMed:38218180). Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Clinicopathological association of CD93 expression in gastric adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The analysis of multiple omics and examination of pathological images revealed the prognostic and therapeutic significances of CD93 in lung squamous cell carcinoma., [RefSeq, PubMed]; The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]., [RefSeq]; [Relationship of cerebrospinal fluid and serum levels of SIL-2R, eNOS, and CD93 with the progression and prognosis of viral encephalitis in children]., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1031,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O00274",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0001849 complement component C1q complex binding;GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0035579 specific granule membrane;GO:0070821 tertiary granule membrane;GO:0030667 secretory granule membrane",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0006909 phagocytosis;GO:0098609 cell-cell adhesion;GO:0042116 macrophage activation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "Q9NPY3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NSY1-1",
        "uniprot_id": "BMP2K_HUMAN",
        "mass": 129172.0,
        "length": 1161,
        "protein_name": "BMP-2-inducible protein kinase",
        "gene_name": "BMP2K",
        "organism": "Human",
        "refseq_name": "BMP-2-inducible protein kinase isoform b",
        "refseq_ac": "NP_060063",
        "gene_names_uniprotkb": "BMP2K; BIKE; HRIHFB2017",
        "gene_names_refseq": "BIKE; BMP2K; HRIHFB2017",
        "protein_names_uniprotkb": "BMP-2-inducible protein kinase; 2.7.11.1; BIKe",
        "protein_names_refseq": "BMP-2-inducible protein kinase isoform b; BMP-2-inducible protein kinase",
        "tax_id": 9606,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:55589)",
        "pathway_count": 1,
        "publication_count": 62,
        "publication_id_list": "11237011;15254968;17081983;17344846;18452278;18691976;19369195;19413330;19651622;19690332;20068231;23186163;24275569;25576301;25892735;26853940;26992070;27600516;28514659;28649982;28657654;28832583;28834231;29242379;29393594;29557506;29632711;30620550;31154438;31530632;31611695;31844290;31848261;32157095;32161166;32488085;32792513;32795391;32938750;32983136;33141586;33592498;33912179;33936100;33968037;34019948;34171305;34357683;34932366;35051231;35132862;35254053;35452674;35580925;35705054;36010968;36241641;36284347;38665916;40307207;40596516;9853615",
        "class_list": "",
        "function": "May be involved in osteoblast differentiation., [UniProtKB, UniProtKB]; PGE2 produced by COX-2 increased BMP-2 expression via binding the EP4 receptor., [RefSeq, PubMed]; Regulation of BMP2K in AP2M1-mediated EGFR internalization during the development of gallbladder cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells. Publication Status: Online-Only, [RefSeq, PubMed]; The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection., [RefSeq, PubMed]; This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 32,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O94791;Q4W5H2;Q8IYF2;Q8N2G7;Q8NHG9;Q9NTG8",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0035612 AP-2 adaptor complex binding;GO:0019208 phosphatase regulator activity;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0045747 positive regulation of Notch signaling pathway;GO:2000369 regulation of clathrin-dependent endocytosis;GO:0030500 regulation of bone mineralization",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "Q9NSY1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UPA5-1",
        "uniprot_id": "BSN_HUMAN",
        "mass": 416469.0,
        "length": 3926,
        "protein_name": "Protein bassoon",
        "gene_name": "BSN",
        "organism": "Human",
        "refseq_name": "protein bassoon",
        "refseq_ac": "NP_003449",
        "gene_names_uniprotkb": "BSN; KIAA0434; ZNF231",
        "gene_names_refseq": "BSN; ZNF231",
        "protein_names_uniprotkb": "Protein bassoon; Zinc finger protein 231",
        "protein_names_refseq": "neuronal double zinc finger protein; protein bassoon; zinc finger protein 231",
        "tax_id": 9606,
        "disease": "epilepsy (Disease Ontology:DOID:1826)",
        "pathway": " (hsa:8927);  (R-HSA-9662360)",
        "pathway_count": 2,
        "publication_count": 35,
        "publication_id_list": "10025409;10329005;11163272;12628169;12812759;17924679;19165527;19380881;20563614;24715725;25576301;26992070;27869121;28657654;30379171;30524438;31154438;31844290;32161166;32357974;32387766;32502341;32938750;33836029;33912179;33968037;35051231;35154160;36010968;36600631;37340703;38253038;38575728;9679147;9806829",
        "class_list": "",
        "function": "Loss of Bassoon in Bsn mutant mice causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses., [RefSeq, PubMed]; Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008]., [RefSeq]; Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease., [RefSeq, PubMed]; Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; This paper describes the structure of the mouse and rat Bsn genes, and characterizes the subcellular distribution of the Bassoon protein., [RefSeq, PubMed]; Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia., [RefSeq, PubMed]; Variants in BSN gene associated with epilepsy with favourable outcome., [RefSeq, PubMed]",
        "predicted_glycosites": 10,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 10,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 4,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 79,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 79,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 79,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 28,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 155,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 89,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43161;Q7LGH3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0004857 enzyme inhibitor activity;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0009986 cell surface;GO:0014069 postsynaptic density",
        "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0007268 chemical synaptic transmission;GO:0050804 modulation of chemical synaptic transmission;GO:0035418 protein localization to synapse;GO:1904071 presynaptic active zone assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "Q9UPA5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NE02-1",
        "uniprot_id": "BTBDH_HUMAN",
        "mass": 52471.0,
        "length": 478,
        "protein_name": "BTB/POZ domain-containing protein 17",
        "gene_name": "BTBD17",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing protein 17 precursor",
        "refseq_ac": "NP_001073935",
        "gene_names_uniprotkb": "BTBD17",
        "gene_names_refseq": "BTBD17A; BTBD17; LGALS3BPL; TANGO10A",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein 17; Galectin-3-binding protein-like",
        "protein_names_refseq": "BTB (POZ) domain containing 17; BTB/POZ and BACK domain-containing protein LOC388419; BTB/POZ domain-containing protein 17 precursor; BTB/POZ domain-containing protein 17; transport and golgi organization 10 homolog A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:388419)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "35051231",
        "class_list": "glycogene",
        "function": "",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 613,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0045071 negative regulation of viral genome replication;GO:0009615 response to virus",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A6NE02-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MX76-1",
        "uniprot_id": "CAN14_HUMAN",
        "mass": 79568.0,
        "length": 684,
        "protein_name": "Calpain-14",
        "gene_name": "CAPN14",
        "organism": "Human",
        "refseq_name": "calpain-14 isoform 1",
        "refseq_ac": "NP_001138594",
        "gene_names_uniprotkb": "CAPN14",
        "gene_names_refseq": "CAPN14",
        "protein_names_uniprotkb": "Calpain-14; 3.4.22.-; CANP 14; Calcium-activated neutral proteinase 14",
        "protein_names_refseq": "CANP 14; calcium-activated neutral proteinase 14; calpain-14 isoform 1",
        "tax_id": 9606,
        "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); eosinophilic esophagitis (Disease Ontology:DOID:13922); hereditary spastic paraplegia (Disease Ontology:DOID:2476)",
        "pathway": " (hsa:440854);  (R-HSA-1474228)",
        "pathway_count": 2,
        "publication_count": 58,
        "publication_id_list": "10229672;10386589;10706100;10809722;10986281;11237011;11375993;11675017;11872628;12727852;12843408;14973287;15234972;15591058;15958533;16133547;1649600;16631740;16825321;1698775;1707285;17332331;17354228;17608959;18434311;18658137;19010778;19571574;19657146;19714641;20142769;21030783;21297635;21441952;21670566;21784848;21864727;22159414;23035980;23845380;24366607;25407941;28131390;28904123;30626591;31844290;33008138;33446329;35051231;7075587;7547873;8226919;8626565;9065415;9115292;9148753;9461298;9852107",
        "class_list": "",
        "function": "CAPN14 is a unique protease with distinct tissue-specific expression and function in patients with EoE and is a potential therapeutic target for EoE and related eosinophilic and allergic diseases Review article, [RefSeq, PubMed]; Calcium-regulated non-lysosomal thiol-protease., [UniProtKB]; Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10964513]). CAPN14 belongs to the calpain large subunit family.[supplied by OMIM, Mar 2008]., [RefSeq]; Eosinophilic esophagitis was associate with increased expression of CAPN14. Publication Status: Online-Only, [RefSeq, PubMed]; Pathogenesis of Eosinophilic Esophagitis: A Comprehensive Review of the Genetic and Molecular Aspects. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The risk variant (SNP) in CAPN14 promoter dampens CAPN14 expression in differentiated esophageal epithelial cells following IL-13/STAT6 induction of CAPN14 promoter activity. Publication Status: Online-Only, [RefSeq, PubMed]; Very early onset eosinophilic esophagitis is common, responds to standard therapy, and demonstrates enrichment for CAPN14 genetic variants., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KRU9",
        "ec_number_list": "3.4.22.53;3.4.22.-;3.4.22.52;3.4.22.54",
        "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "A8MX76-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00327-2",
        "uniprot_id": "BMAL1_HUMAN",
        "mass": 68762.0,
        "length": 626,
        "protein_name": "Basic helix-loop-helix ARNT-like protein 1",
        "gene_name": "BMAL1",
        "organism": "Human",
        "refseq_name": "basic helix-loop-helix ARNT-like protein 1 isoform a",
        "refseq_ac": "NP_001025443",
        "gene_names_uniprotkb": "BMAL1; ARNTL; BHLHE5; MOP3; PASD3",
        "gene_names_refseq": "ARNTL1; ARNTL; BMAL1c; BMAL1; JAP3; MOP3; PASD3; TIC; bHLHe5",
        "protein_names_uniprotkb": "Basic helix-loop-helix ARNT-like protein 1; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic-helix-loop-helix-PAS protein MOP3; Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; Member of PAS protein 3; PAS domain-containing protein 3; bHLH-PAS protein JAP3; bHLHe5",
        "protein_names_refseq": "ARNT-like protein 1, brain and muscle; PAS domain containing 3; PAS domain-containing protein 3; aryl hydrocarbon receptor nuclear translocator like; aryl hydrocarbon receptor nuclear translocator-like protein 1; bHLH-PAS protein JAP3; basic helix-loop-helix ARNT-like protein 1 isoform a; basic helix-loop-helix ARNT-like protein 1; basic helix-loop-helix family member e5; basic-helix-loop-helix-PAS orphan MOP3; basic-helix-loop-helix-PAS protein MOP3; brain and muscle ARNT-like 1; class E basic helix-loop-helix protein 5; member of PAS protein 3; member of PAS superfamily 3; mutant basic helix-loop-helix ARNT-like protein 1; testis tissue sperm-binding protein Li 50e",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); cholestasis (Disease Ontology:DOID:13580); bipolar disorder (Disease Ontology:DOID:3312); diabetes mellitus (Disease Ontology:DOID:9351)",
        "pathway": " (hsa:406);  (R-HSA-1368108);  (R-HSA-1989781);  (R-HSA-9707616);  (R-HSA-9768919);  (R-HSA-9931509);  (R-HSA-9931510);  (R-HSA-9931512);  (R-HSA-9931521);  (R-HSA-9931529)",
        "pathway_count": 10,
        "publication_count": 119,
        "publication_id_list": "10198158;10381560;10777541;10857746;11018023;11162494;11241162;11267664;11387216;11441146;12118000;12130498;12130638;12177166;12356737;12377782;12406875;12505311;12511571;12582161;12738229;14645221;14672706;14701734;14750904;15067378;15130092;15175654;15500444;15560782;15635043;15665827;15761026;16380219;16474406;16857194;16972786;17994337;18006707;18037887;18317514;18540824;18587630;18719978;18848529;19088433;19330005;19710360;19710929;1971514;19934321;20049328;20110263;20581824;20817722;20977903;21368041;21479263;21628546;21960634;23229515;23303907;23395176;23576606;23785138;23916625;23955654;24005054;24196956;24291638;24312621;24385426;24465693;24728990;2539258;25892735;25936801;26562092;27153104;27472814;27754849;28111073;28832583;28903391;28985504;29242379;29626158;2991279;30530698;31092671;31748741;31844290;32354867;32695117;32938616;3345742;34545347;35051231;35580925;38805270;38908531;38956298;39265843;39341782;40596516;7685352;7892212;7981125;8415693;8618898;8622974;8647822;8887638;9012850;9079689;9144434;9576906;9616112;9748239",
        "class_list": "",
        "function": "(Microbial infection) Regulates SARS coronavirus-2/SARS-CoV-2 entry and replication in lung epithelial cells probably through the post-transcriptional regulation of ACE2 and interferon-stimulated gene expression., [UniProtKB, PubMed]; Arntl-induced upregulation of DUSP1 inhibits tumor progression in esophageal squamous cell carcinoma by inactivating ERK signaling., [RefSeq, PubMed]; BMAL1 plays a crucial role in immune homeostasis during sepsis-induced acute lung injury., [RefSeq, PubMed]; Bmal1 regulates the stemness and tumorigenesis of gliomas with the Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]; Circadian disruption reduces MUC4 expression via the clock molecule BMAL1 during dry eye development., [RefSeq, PubMed]; Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells., [RefSeq, PubMed]; The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19. [provided by RefSeq, Oct 2021]., [RefSeq]; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2I2N6;A8K645;B5ME11;B7WPG7;D3DQW6;O00313;O00314;O00315;O00316;O00317;Q4G136;Q8IUT4;Q99631;Q99649",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0017162 aryl hydrocarbon receptor binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0034751 aryl hydrocarbon receptor complex;GO:0016605 PML body",
        "go_biological_process": "GO:1901985 positive regulation of protein acetylation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "O00327-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NPJ1-1",
        "uniprot_id": "MKKS_HUMAN",
        "mass": 62342.0,
        "length": 570,
        "protein_name": "Molecular chaperone MKKS",
        "gene_name": "MKKS",
        "organism": "Human",
        "refseq_name": "molecular chaperone MKKS",
        "refseq_ac": "NP_061336",
        "gene_names_uniprotkb": "MKKS; BBS6",
        "gene_names_refseq": "BBS6; HMCS; KMS; MKKS; MKS",
        "protein_names_uniprotkb": "Molecular chaperone MKKS; Bardet-Biedl syndrome 6 protein; McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin",
        "protein_names_refseq": "Bardet-Biedl syndrome 6 protein; McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin; alternative protein MKKS; molecular chaperone MKKS",
        "tax_id": 9606,
        "disease": "ciliopathy (Disease Ontology:DOID:0060340); Bardet-Biedl syndrome 6 (Disease Ontology:DOID:0110128); McKusick-Kaufman syndrome (Disease Ontology:DOID:0111255); congenital heart disease (Disease Ontology:DOID:1682); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:8195);  (R-HSA-5620922)",
        "pathway_count": 2,
        "publication_count": 51,
        "publication_id_list": "10802661;10973238;10973251;11179009;11252952;11567139;12107442;12677556;12837689;12920096;15258860;15314642;15483080;15666242;15731008;15770229;16327777;17574030;18094050;19081074;19421068;19575670;20080638;20120035;20233871;20603001;21344540;21427764;22072986;22139371;22152675;22389062;22500027;23351793;23671934;24296415;25443296;25446516;26900326;28753627;28761321;30379171;30779550;32157095;32387766;32938616;33144677;33741323;33936100;33968037;35051231",
        "class_list": "",
        "function": "Apparent but unconfirmed digenism in an Iranian consanguineous family with syndromic Retinal Disease., [RefSeq, PubMed]; Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (PubMed:20080638). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis (PubMed:28753627)., [UniProtKB, PubMed, PubMed]; This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 6, also known as McKusick-Kaufman syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2023]., [RefSeq]; Three uORFs (uMKKS0, uMKKS1 and uMKKS2) are reported, and they can repress the translation of the downstream MKKS ORF. uMKKS1 and uMKKS2 are highly conserved in mammals and they encode two different mitochondrial membrane proteins respectively., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7B0;D3DW18",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0031514 motile cilium",
        "go_biological_process": "GO:0007507 heart development;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0021766 hippocampus development;GO:0021987 cerebral cortex development;GO:0007286 spermatid development",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q9NPJ1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13253-1",
        "uniprot_id": "NOGG_HUMAN",
        "mass": 25774.0,
        "length": 232,
        "protein_name": "Noggin",
        "gene_name": "NOG",
        "organism": "Human",
        "refseq_name": "noggin precursor",
        "refseq_ac": "NP_005441",
        "gene_names_uniprotkb": "NOG",
        "gene_names_refseq": "NOG; SYM1; SYNS1A; SYNS1",
        "protein_names_uniprotkb": "Noggin",
        "protein_names_refseq": "noggin precursor; symphalangism 1 (proximal)",
        "tax_id": 9606,
        "disease": "proximal symphalangism (Disease Ontology:DOID:0050788); tarsal-carpal coalition syndrome (Disease Ontology:DOID:0050789); multiple synostoses syndrome (Disease Ontology:DOID:0050794); esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); proximal symphalangism 1 (Disease Ontology:DOID:0080787); multiple synostoses syndrome 1 (Disease Ontology:DOID:0081317); brachydactyly type B2 (Disease Ontology:DOID:0110975); acute kidney tubular necrosis (Disease Ontology:DOID:12556); Huntington's disease (Disease Ontology:DOID:12858); craniosynostosis (Disease Ontology:DOID:2340); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); cleft lip (Disease Ontology:DOID:9296); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hyperopia (Disease Ontology:DOID:9834); stapes ankylosis with broad thumbs and toes (MONDO:MONDO:0008484)",
        "pathway": " (hsa:9241);  (R-HSA-201451);  (R-HSA-9793380)",
        "pathway_count": 3,
        "publication_count": 51,
        "publication_id_list": "10.1101/2023.09.13.557529;10080184;10458166;10587654;10712517;11016919;11121043;11158580;11278251;11509558;11545688;11571290;11714695;11779505;11846737;11857750;12089654;12151385;12478285;12519765;12592392;12821673;12857866;15770128;16672363;17029022;17068149;17311849;17356069;17668388;20503332;21976273;24098149;26643732;28178531;30459171;31138930;34001012;34051144;35051231;36529041;36642181;38509118;7644468;7666191;7791754;8119126;8653785;8893010;9136927;9436979",
        "class_list": "",
        "function": "Differential compartmentalization of BMP4/NOGGIN requires NOGGIN trans-epithelial transport., [RefSeq, PubMed]; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732)., [UniProtKB, PubMed, PubMed, PubMed]; Noggin promotes osteogenesis in human adipose-derived mesenchymal stem cells via FGFR2/Src/Akt and ERK signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Noggin-mediated effects on metabolite profiles of microglia and oligodendrocytes after ischemic insult., [RefSeq, PubMed]; Prognostic value of noggin protein expression in patients with resected gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition., [RefSeq, PubMed]; The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 15,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity;GO:0141069 receptor ligand inhibitor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0098793 presynapse",
        "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0008283 cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q13253-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "B2RXF5-1",
        "uniprot_id": "ZBT42_HUMAN",
        "mass": 46491.0,
        "length": 422,
        "protein_name": "Zinc finger and BTB domain-containing protein 42",
        "gene_name": "ZBTB42",
        "organism": "Human",
        "refseq_name": "zinc finger and BTB domain-containing protein 42",
        "refseq_ac": "NP_001131073",
        "gene_names_uniprotkb": "ZBTB42",
        "gene_names_refseq": "LCCS6; ZBTB42; ZNF925",
        "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 42",
        "protein_names_refseq": "zinc finger and BTB domain-containing protein 42",
        "tax_id": 9606,
        "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); lethal congenital contracture syndrome (Disease Ontology:DOID:0060558); lethal congenital contracture syndrome 6 (Disease Ontology:DOID:0061262)",
        "pathway": " (hsa:100128927)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "21193930;25055871;27862975;29557506;31844290",
        "class_list": "",
        "function": "Data show that ZBTB42 protein is expressed in human skeletal muscle and a murine cell line C2C12 myotubes., [RefSeq, PubMed]; The protein encoded by this gene is a member of the C2H2 zinc finger protein family. This protein is predicted to have a pox virus and zinc finger (POZ) domain at the N-terminus and four zinc finger domains at the C-terminus. In human and mouse, the protein localizes to the nuclei of skeletal muscle cells. Knockdown of this gene in zebrafish results in abnormal skeletal muscle development and myofibrillar disorganization. A novel homozygous variant of the human gene has been associated with lethal congenital contracture syndrome, an autosomal recessive disorder that results in muscle wasting. [provided by RefSeq, Mar 2015]., [RefSeq]; Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes., [UniProtKB, UniProtKB]; ZBTB42 mutation defines a novel lethal congenital contracture syndrome., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZW21",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "B2RXF5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y3M9-1",
        "uniprot_id": "ZN337_HUMAN",
        "mass": 86875.0,
        "length": 751,
        "protein_name": "Zinc finger protein 337",
        "gene_name": "ZNF337",
        "organism": "Human",
        "refseq_name": "zinc finger protein 337",
        "refseq_ac": "NP_001277190",
        "gene_names_uniprotkb": "ZNF337",
        "gene_names_refseq": "ZNF337",
        "protein_names_uniprotkb": "Zinc finger protein 337",
        "protein_names_refseq": "zinc finger protein 337",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26152);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 35,
        "publication_id_list": "10235266;10330177;11395415;14519192;15175151;15896744;16606702;16719718;18491316;2163759;25755297;25880248;27920218;28218747;28832583;28834231;29242379;29437277;29493099;29557506;29786170;30315122;30429286;31844290;32157095;32357974;32983136;33298915;33912179;33968037;35051231;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]; This gene encodes a zinc finger domain containing protein. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DSM2;Q9Y3Y5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q9Y3M9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95931-1",
        "uniprot_id": "CBX7_HUMAN",
        "mass": 28341.0,
        "length": 251,
        "protein_name": "Chromobox protein homolog 7",
        "gene_name": "CBX7",
        "organism": "Human",
        "refseq_name": "chromobox protein homolog 7 isoform 1",
        "refseq_ac": "NP_783640",
        "gene_names_uniprotkb": "CBX7",
        "gene_names_refseq": "CBX7",
        "protein_names_uniprotkb": "Chromobox protein homolog 7",
        "protein_names_refseq": "chromobox protein homolog 7 isoform 1; chromobox protein homolog 7",
        "tax_id": 9606,
        "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); anaplastic thyroid carcinoma (Disease Ontology:DOID:0080522); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); clear cell adenocarcinoma (Disease Ontology:DOID:4468); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); oncocytic carcinoma of the thyroid (Disease Ontology:DOID:8161); myeloid leukemia (Disease Ontology:DOID:8692); multiple myeloma (Disease Ontology:DOID:9538)",
        "pathway": " (hsa:23492)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;14647293;17374722;18477386;19636380;19791798;20696397;21047797;21060834;21282530;23481700;29557506;29789417;32983136;33392160;35051231;35580925;37791390;38037081;39033888;39179168",
        "class_list": "",
        "function": "A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and promotes glioma cell growth., [RefSeq, PubMed]; Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; CBX7 is a chromobox protein causally linked to cancer development, [RefSeq, PubMed]; CBX7 promotes choroidal neovascularization by activating the HIF-1alpha/VEGF pathway in choroidal vascular endothelial cells., [RefSeq, PubMed]; CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44/c-MYC/LDHA axis., [RefSeq, PubMed]; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Controls cellular lifespan through regulation of both the p16(Ink4a)/Rb and the Arf/p53 pathways Erratum:[Nat Cell Biol. 2022 Sep;24(9):1445. doi: 10.1038/s41556-022-00956-2. PMID: 35941232], [RefSeq, PubMed]; This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 18,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86T17",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0031519 PcG protein complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0031507 heterochromatin formation;GO:0006325 chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "O95931-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H444-1",
        "uniprot_id": "CHM4B_HUMAN",
        "mass": 24950.0,
        "length": 224,
        "protein_name": "Charged multivesicular body protein 4b",
        "gene_name": "CHMP4B",
        "organism": "Human",
        "refseq_name": "charged multivesicular body protein 4b",
        "refseq_ac": "NP_789782",
        "gene_names_uniprotkb": "CHMP4B; C20orf178; SHAX1",
        "gene_names_refseq": "C20orf178; CHMP4A; CHMP4B; CTPP3; CTRCT31; SNF7-2; SNF7; Shax1; VPS32B; Vps32-2; dJ553F4.4",
        "protein_names_uniprotkb": "Charged multivesicular body protein 4b; CHMP4b; Chromatin-modifying protein 4b; SNF7 homolog associated with Alix 1; SNF7-2; Vacuolar protein sorting-associated protein 32-2; Vps32-2; hSnf7-2; hVps32-2",
        "protein_names_refseq": "SNF7 homolog associated with Alix 1; Snf7 homologue associated with Alix 1; charged multivesicular body protein 4b; chromatin modifying protein 4B; chromatin-modifying protein 4b; vacuolar protein-sorting-associated protein 32-2",
        "tax_id": 9606,
        "disease": "cataract 31 multiple types (Disease Ontology:DOID:0110265)",
        "pathway": " (hsa:128866);  (R-HSA-162588);  (R-HSA-1632852);  (R-HSA-5620971);  (R-HSA-917729);  (R-HSA-9610379);  (R-HSA-9615710);  (R-HSA-9668328);  (R-HSA-9679504);  (R-HSA-9694676)",
        "pathway_count": 10,
        "publication_count": 167,
        "publication_id_list": "11096062;11563910;11825910;12860994;14505569;14505570;14519844;14583093;14624836;14678797;15007060;15075231;15187094;15218037;15331731;15473846;15511219;16371348;16856878;16897187;16963840;16973552;17146056;17428861;17618624;17701905;18190528;18209100;18321988;18434552;18439900;18511562;19211835;19322194;19527882;19590496;19608861;19640981;19855179;19859801;19898463;20059746;20068231;20713597;20921139;21177865;21205641;21238931;21258367;21310966;21383122;21406692;21460621;21543490;21757351;21799305;21819378;2204156;22170151;22422861;22660413;22682742;22762019;23202584;23266279;23305486;23481700;23685627;23727157;23884233;24714562;24715725;24747438;24954904;25135833;25484072;25502872;25568151;25880248;25961502;26040712;26040713;26154972;26375003;26375851;26508369;26728094;26992070;27281216;27383986;27418190;27600516;27846572;27862975;27920218;2799391;28045099;28063628;28218747;28228285;28242692;28392147;28446606;28459430;28832583;28834231;28860189;29177860;29242379;29331515;29393594;29437277;29493099;29508533;29539421;29557506;29632046;29786170;29891674;29898893;29990470;30143555;30315122;30410026;30429286;30513301;30833945;30976076;31113851;31154438;31231549;31530632;31844290;31998317;32109412;32157095;32188940;32265295;32350084;32357974;32367036;32502341;32820063;32938616;32983136;33298915;33349255;33592498;33717175;33936100;33968037;33981976;34019948;34171305;34357683;34433824;35051231;35154160;35251023;35318648;35580925;36010968;36284347;37487085;37931722;39302247;7628435",
        "class_list": "",
        "function": "(Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma., [RefSeq, PubMed]; CHMP4b and Alix participate in formation of multivesicular bodies by cooperating with SKD1, [RefSeq, PubMed]; HSP90beta prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53., [RefSeq, PubMed]; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Majority of the protein exists in a folded closed conformation (PubMed:33349255)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Study demonstrates that CHMP4A and CHMP4B proteins form novel membrane-attached filaments that can promote or stabilize negative curvature and outward budding., [RefSeq, PubMed]; These data provide the first evidence that CHMP4B plays a vital role the maintenance of lens transparency., [RefSeq, PubMed]; This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P5N4;Q53ZD6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0000421 autophagosome membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope",
        "go_biological_process": "GO:0001778 plasma membrane repair;GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 17.0,
        "record_id": "Q9H444-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BU23-1",
        "uniprot_id": "LMF2_HUMAN",
        "mass": 79698.0,
        "length": 707,
        "protein_name": "Lipase maturation factor 2",
        "gene_name": "LMF2",
        "organism": "Human",
        "refseq_name": "lipase maturation factor 2 isoform 1",
        "refseq_ac": "NP_149977",
        "gene_names_uniprotkb": "LMF2; TMEM112B; TMEM153",
        "gene_names_refseq": "LMF2; TMEM112B; TMEM153",
        "protein_names_uniprotkb": "Lipase maturation factor 2; Transmembrane protein 112B; Transmembrane protein 153",
        "protein_names_refseq": "lipase maturation factor 2 isoform 1; transmembrane protein 112B; transmembrane protein 153",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91289);  (R-HSA-8963889)",
        "pathway_count": 2,
        "publication_count": 98,
        "publication_id_list": "10.1101/2023.09.13.557529;10900462;1301939;15284087;15800215;16109723;16959974;17088546;17883852;17994020;17997385;18452278;18691976;19304573;19361614;19413330;20356926;20581395;21666694;21719679;21844202;22262056;22569073;22740495;23020258;23150577;24190977;24397894;24715725;24909692;24960069;25387803;25418920;25576301;25645385;26375851;26742120;26811146;26929215;26933753;26934567;26934667;26992070;27397612;27846572;27862975;27920218;28063628;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29632711;29741879;29786170;30315122;30410026;30429286;31844290;32157095;32265295;32350084;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33691108;33912179;33968037;34171305;34211107;34405274;34509645;35051231;35580925;35705054;36010968;36241641;36284347;37074911;7592670;8020465;8485124;9136889;9379936",
        "class_list": "",
        "function": "DNA methylation in the NCAPH2/LMF2 promoter region is significantly decreased in Alzheimer disease. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 9,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NEZ0;Q13392;Q6ZNR2;Q8WU74;Q96C62",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0051604 protein maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.1,
        "record_id": "Q9BU23-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q06587-1",
        "uniprot_id": "RING1_HUMAN",
        "mass": 42429.0,
        "length": 406,
        "protein_name": "E3 ubiquitin-protein ligase RING1",
        "gene_name": "RING1",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase RING1",
        "refseq_ac": "NP_002922",
        "gene_names_uniprotkb": "RING1; RING1A; RNF1",
        "gene_names_refseq": "RING1A; RING1; RNF1",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RING1; 2.3.2.27; Polycomb complex protein RING1; RING finger protein 1; RING-type E3 ubiquitin transferase RING1; Really interesting new gene 1 protein",
        "protein_names_refseq": "E3 ubiquitin-protein ligase RING1; RING-type E3 ubiquitin transferase RING1; polycomb complex protein RING1; really interesting new gene 1 protein",
        "tax_id": 9606,
        "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); Luo-Schoch-Yamamoto syndrome (Disease Ontology:DOID:0070416); cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:6015);  (R-HSA-2559580);  (R-HSA-3108214);  (R-HSA-3899300);  (R-HSA-4551638);  (R-HSA-4570464);  (R-HSA-4655427);  (R-HSA-8939243);  (R-HSA-8943724);  (R-HSA-8953750);  (R-HSA-9976102)",
        "pathway_count": 11,
        "publication_count": 275,
        "publication_id_list": "10.1101/2023.09.13.557529;10347217;10574707;10722742;10772813;10871633;11171983;11378386;11477070;11545734;11564866;11735126;11781575;11792325;11842083;11889051;11959846;11960997;12004135;12032081;12134156;12150977;12167161;12167701;12189133;12193592;12196509;12421820;12435631;12529333;12679040;12718889;12808055;12909625;13130464;14507994;14532106;14578449;14701874;15014447;15082759;15161980;15175327;15199155;15287722;15355988;15386022;15536069;15563468;15592428;15608651;15766567;15823533;15829507;15866172;15940266;15958389;15959518;15976810;16030353;16098147;16186825;16337592;16359901;16418168;16436515;16478998;16608850;16626738;16676006;16688858;16702404;16757475;16810316;16826196;16917507;16943429;17001316;17018294;17079232;17081983;17081986;17210787;17254968;17255097;17298944;17332741;17344414;17369852;17395714;17535915;17600109;17693435;17765224;17803295;17825402;17873065;17875933;17942393;17974977;18082607;18172008;18211901;18220336;18339323;18365017;18391013;18408014;18452278;18487508;18488044;18562691;18625722;18628979;18669648;18691969;18695000;18708356;18762900;18793328;19240082;19287951;19440552;19450230;19451217;19451218;19462008;19528227;19596686;19615980;19622798;19636380;19690332;19706679;19779455;19884659;19956565;19995069;20016594;20016603;20068231;20098713;20176810;20190268;20233713;20305658;20351170;20417598;20506188;20516213;20676127;20705237;20797632;20797634;21098080;21147198;21284855;21289308;21338522;21527249;21550342;21596310;21647297;21986495;22020331;22128185;22325351;22325352;22336108;22402492;22467880;22493095;22508508;22635276;22661230;22683641;22713328;22751501;22825850;23092970;23186163;23287862;23301498;23404503;23673342;23750026;23871147;23954429;24027577;24068740;24275569;24369422;24627085;24714562;24715725;24718924;24782567;25114211;25218447;25391492;25576301;25645385;25704882;25725044;25728608;25800734;25892735;26375851;26910647;27068747;27600516;27846572;27920218;28228285;28832583;28839133;28904123;29242379;29393594;29557506;29632711;29786170;30315122;30429286;31154438;31839203;31844290;32157095;32357974;32897882;32983136;33141586;33912179;33968037;34019948;35580925;36413948;37797799;38219048;39256363;40307207;7535770;7588633;7623816;7681583;7816143;7859739;8001816;8078588;8259215;8319905;8622669;8622688;8626550;8741839;8774846;8846784;8974401;9030721;9162092;9195981;9199346;9412458;9452416;9501179;9529249;9564042;9628874;9689056;9704927;9756909;9768359;9824166;9858531;9885291",
        "class_list": "",
        "function": "Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity., [UniProtKB, PubMed]; Essential role of MESP1-RING1A complex in cardiac differentiation., [RefSeq, PubMed]; RING induces cell cycle arrest and apoptosis in human breast cancer cells by regulating the HSF1/MT2A axis., [RefSeq, PubMed]; RING1 Inhibition Has a Cell-Specific Antitumoral Role by Promoting Autophagy in Endometrial Cancer Cells., [RefSeq, PubMed]; RING1 missense variants reveal sensitivity of DNA damage repair to H2A monoubiquitination dosage during neurogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8JZZ0;Q5JP96;Q5SQW2;Q86V19",
        "ec_number_list": "2.3.2.-;2.7.11.1;1.14.11.68;3.5.1.-;3.5.1.98;1.14.11.-;1.14.11.65;1.14.99.66;2.1.1.367;2.1.1.-;2.1.1.364;2.3.2.27;2.3.1.48;2.3.1.-;3.6.4.-;1.1.1.-;2.7.11.24;2.1.1.356;2.3.1.57;3.5.1.48;3.5.1.62;2.1.1.37",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0097027 ubiquitin-protein transferase activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin;GO:0000151 ubiquitin ligase complex",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 28.0,
        "record_id": "Q06587-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15516-1",
        "uniprot_id": "CLOCK_HUMAN",
        "mass": 95304.0,
        "length": 846,
        "protein_name": "Circadian locomoter output cycles protein kaput",
        "gene_name": "CLOCK",
        "organism": "Human",
        "refseq_name": "circadian locomoter output cycles protein kaput",
        "refseq_ac": "NP_001254772",
        "gene_names_uniprotkb": "CLOCK; BHLHE8; KIAA0334",
        "gene_names_refseq": "CLOCK; KAT13D; bHLHe8",
        "protein_names_uniprotkb": "Circadian locomoter output cycles protein kaput; 2.3.1.48; Class E basic helix-loop-helix protein 8; bHLHe8; hCLOCK",
        "protein_names_refseq": "circadian locomoter output cycles kaput protein; circadian locomoter output cycles protein kaput; class E basic helix-loop-helix protein 8; clock homolog",
        "tax_id": 9606,
        "disease": "hypoinsulinemic hypoglycemia with hemihypertrophy (Disease Ontology:DOID:0112263); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); polycystic ovary syndrome (Disease Ontology:DOID:11612); cholestasis (Disease Ontology:DOID:13580); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); prostate adenocarcinoma (Disease Ontology:DOID:2526); carcinoma (Disease Ontology:DOID:305); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); bipolar disorder (Disease Ontology:DOID:3312); ovarian carcinoma (Disease Ontology:DOID:4001); sleep disorder (Disease Ontology:DOID:535); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)",
        "pathway": " (hsa:9575);  (R-HSA-1368108);  (R-HSA-1989781);  (R-HSA-3214847);  (R-HSA-9707616);  (R-HSA-9931509);  (R-HSA-9931510);  (R-HSA-9931512);  (R-HSA-9931521);  (R-HSA-9931529)",
        "pathway_count": 10,
        "publication_count": 144,
        "publication_id_list": "10198158;10381560;10777541;10786633;10821277;10857746;11018023;11162494;11237011;11241162;11267664;11387216;11441146;12118000;12130498;12130638;12177166;12356737;12377782;12406875;12505311;12511571;12582161;12738229;14645221;14672706;14750904;15067378;15130092;15175654;15313887;15500444;15560782;15635043;15665827;15761026;16380219;16387653;16474406;16857194;16972786;17994337;18006707;18037887;18317514;18381289;18540824;18587630;18623064;18719978;18848529;19088433;19187765;19710360;19710929;1971514;19934321;19946213;20018852;20110263;20581824;20817722;20861012;21479263;21613214;21628546;21659603;21960634;21980503;22284746;23160374;23229515;23303907;23395176;23576606;23785138;23916625;24005054;24196956;24235147;2539258;25418920;25936801;26154972;26811146;26929215;26992070;27754849;27846572;28063628;28111073;28657654;28834231;28903391;28985504;29242379;29393594;29557506;29632046;2991279;30429286;30530698;31154438;31748741;31844290;31848261;32157095;32354867;32357974;32387766;32488085;32695117;32938616;3345742;33592498;33968037;34019948;34087483;34185709;35051231;35254053;35580925;36010968;38492220;38665916;38676534;38805270;38871225;40596516;7685352;7892212;7981125;8415693;8618898;8622974;8647822;8887638;9012850;9079689;9144434;9427644;9558366;9748239;9880483",
        "class_list": "",
        "function": "CLOCK gene circannual expression in cluster headache. Erratum:[Cephalalgia. 2024 Dec;44(12):3331024241303592. doi: 10.1177/03331024241303592. PMID: 39691983], [RefSeq, PubMed]; Essential regulator of circadian rhythms, [RefSeq, PubMed]; Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells., [RefSeq, PubMed]; The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]., [RefSeq]; The role of circadian gene CLOCK in cancer. Review article, [RefSeq, PubMed]; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; YTHDF1-CLOCK axis contributes to pathogenesis of allergic airway inflammation through LLPS., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 25,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AV01;A2I2N9;O14516;Q9UIT8",
        "ec_number_list": "2.3.1.48;2.3.1.-;3.5.1.-;3.5.1.98;3.4.21.21;2.7.11.1;2.4.2.12;2.7.11.26;2.1.1.-;2.1.1.364;3.6.4.-;2.1.1.319;2.3.1.57;2.3.1.286;3.1.13.1;5.6.2.6;3.6.4.13;2.3.1.259;2.3.1.80;3.1.3.108",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0007283 spermatogenesis;GO:0051775 response to redox state",
        "synthesized_glycan_count": 0,
        "hit_score": 14.7,
        "record_id": "O15516-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6NW40-1",
        "uniprot_id": "RGMB_HUMAN",
        "mass": 47547.0,
        "length": 437,
        "protein_name": "Repulsive guidance molecule B",
        "gene_name": "RGMB",
        "organism": "Human",
        "refseq_name": "repulsive guidance molecule B isoform 2",
        "refseq_ac": "NP_001012779",
        "gene_names_uniprotkb": "RGMB",
        "gene_names_refseq": "DRAGON; RGMB",
        "protein_names_uniprotkb": "Repulsive guidance molecule B; DRAGON; DRG11-responsive axonal guidance and outgrowth of neurite",
        "protein_names_refseq": "DRG11-responsive axonal guidance and outgrowth of neurite; RGM domain family, member B; repulsive guidance molecule B isoform 2; repulsive guidance molecule B; repulsive guidance molecule family member b",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285704);  (R-HSA-373752)",
        "pathway_count": 2,
        "publication_count": 32,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;11237011;12154370;16762451;17174565;19324014;21617229;23584533;23744777;25576301;25813380;26055877;26154972;26910889;27846572;29557506;31061392;31844290;32157095;32576689;32983136;33141586;33298915;33717175;33912179;34211107;34357683;35051231;35580925;36153321;9858595",
        "class_list": "",
        "function": "Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth., [UniProtKB, PubMed, UniProtKB]; Our results demonstrate that RGMB is an important inhibitor of non-small cell lung cancer metastasis and that low RGMB expression is a novel predictor or a poor prognosis., [RefSeq, PubMed]; RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4. Publication Status: Online-Only, [RefSeq, PubMed]; RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]., [RefSeq]; RGMB was down-regulation in non-small cell lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival. Publication Status: Online-Only, [RefSeq, PubMed]; Reduced expression of RGMB in breast cancer was associated with breast cancer., [RefSeq, PubMed]; Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
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        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6R9A0;Q8NC92",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015026 coreceptor activity;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0098552 side of membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0045893 positive regulation of DNA-templated transcription;GO:0030509 BMP signaling pathway;GO:0010604 positive regulation of macromolecule metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "Q6NW40-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96D03-1",
        "uniprot_id": "DDT4L_HUMAN",
        "mass": 21740.0,
        "length": 193,
        "protein_name": "DNA damage-inducible transcript 4-like protein",
        "gene_name": "DDIT4L",
        "organism": "Human",
        "refseq_name": "DNA damage-inducible transcript 4-like protein",
        "refseq_ac": "NP_660287",
        "gene_names_uniprotkb": "DDIT4L; REDD2; RTP801L",
        "gene_names_refseq": "DDIT4L; REDD2; Rtp801L",
        "protein_names_uniprotkb": "DNA damage-inducible transcript 4-like protein; HIF-1 responsive protein RTP801-like; Protein regulated in development and DNA damage response 2; REDD-2",
        "protein_names_refseq": "DNA damage-inducible transcript 4-like protein; HIF-1 responsive protein RTP801-like; REDD-2; homolog of mouse SMHS1; protein regulated in development and DNA damage response 2; regulated in development and DNA damage response 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:115265)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;12453409;15308555;15545625;15632201;19268525;19491193;31154438",
        "class_list": "",
        "function": "Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Mediates monocyte cell death through a reduction in thioredoxin-1 expression, [RefSeq, PubMed]; Promoter methylation and differential gene expression of five markers: COL1A2, NPM2, HSPB6, DDIT4L and MT1G were validated by sequencing of bisulfite-modified DNA and real-time reverse transcriptase PCR, respectively., [RefSeq, PubMed]; RTP801 and RTP801L work downstream of AKT and upstream of TSC2 to inhibit mTOR functions, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
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        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7C3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0009968 negative regulation of signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q96D03-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P16104-1",
        "uniprot_id": "H2AX_HUMAN",
        "mass": 15145.0,
        "length": 143,
        "protein_name": "Histone H2AX",
        "gene_name": "H2AX",
        "organism": "Human",
        "refseq_name": "histone H2AX",
        "refseq_ac": "NP_002096",
        "gene_names_uniprotkb": "H2AX; H2AFX",
        "gene_names_refseq": "H2A.X; H2A/X; H2AFX; H2AX",
        "protein_names_uniprotkb": "Histone H2AX; H2a/x; Histone H2A.X",
        "protein_names_refseq": "H2A histone family member X; H2AX histone; histone H2A.x; histone H2AX",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hypertension (Disease Ontology:DOID:10763); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); liver benign neoplasm (Disease Ontology:DOID:916); oral mucosa leukoplakia (Disease Ontology:DOID:9655)",
        "pathway": " (hsa:3014);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214858);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-69473);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9821993);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 53,
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        "class_list": "",
        "function": "H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours. Publication Status: Online-Only, [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015]., [RefSeq]; Hypoxia-responsive lncRNA G077640 promotes ESCC tumorigenesis via the H2AX-HIF1alpha-glycolysis axis., [RefSeq, PubMed]; Machine learning extracts oncogenic-specific gamma-H2AX foci formation pattern upon genotoxic stress., [RefSeq, PubMed]; Overexpression of H2AFX gene in neuroblastoma is associated with worse prognosis., [RefSeq, PubMed]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "prognostic",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4ZGJ7;Q6IAS5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0019899 enzyme binding;GO:0046982 protein heterodimerization activity;GO:0003684 damaged DNA binding;GO:0042393 histone binding",
        "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck",
        "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0006310 DNA recombination;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation",
        "synthesized_glycan_count": 0,
        "hit_score": 117.4,
        "record_id": "P16104-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P35568-1",
        "uniprot_id": "IRS1_HUMAN",
        "mass": 131591.0,
        "length": 1242,
        "protein_name": "Insulin receptor substrate 1",
        "gene_name": "IRS1",
        "organism": "Human",
        "refseq_name": "insulin receptor substrate 1",
        "refseq_ac": "NP_005535",
        "gene_names_uniprotkb": "IRS1",
        "gene_names_refseq": "HIRS-1; IRS1",
        "protein_names_uniprotkb": "Insulin receptor substrate 1; IRS-1",
        "protein_names_refseq": "insulin receptor substrate 1",
        "tax_id": 9606,
        "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); amnestic disorder (Disease Ontology:DOID:10914); osteoporosis (Disease Ontology:DOID:11476); uterine fibroid (Disease Ontology:DOID:13223); coronary artery disease (Disease Ontology:DOID:3393); glucose metabolism disease (Disease Ontology:DOID:4194); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:3667);  (R-HSA-109704);  (R-HSA-112399);  (R-HSA-112412);  (R-HSA-1257604);  (R-HSA-1266695);  (R-HSA-198203);  (R-HSA-201556);  (R-HSA-2219530);  (R-HSA-2428928);  (R-HSA-2586552);  (R-HSA-5673001);  (R-HSA-6811558);  (R-HSA-74713);  (R-HSA-74749);  (R-HSA-9603381);  (R-HSA-9725370);  (R-HSA-982772);  (R-HSA-9842663)",
        "pathway_count": 19,
        "publication_count": 656,
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        "class_list": "",
        "function": "Association of IRS1 gene Pro512Ala polymorphism with nonalcoholic fatty liver disease. Publication Status: Online-Only, [RefSeq, PubMed]; IRS1 promotes thyroid cancer metastasis through EMT and PI3K/AKT pathways., [RefSeq, PubMed]; Sex differences in adipose insulin resistance are linked to obesity, lipolysis and insulin receptor substrate 1., [RefSeq, PubMed]; Sh- Ambra1 inhibits IRS-1/PI3K/Akt signalling pathway to reduce autophagy in gestational diabetes., [RefSeq, PubMed]; Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005158 insulin receptor binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005080 protein kinase C binding;GO:0042169 SH2 domain binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043231 intracellular membrane-bounded organelle",
        "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0032869 cellular response to insulin stimulus",
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        "hit_score": 66.2,
        "record_id": "P35568-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y2Q5-1",
        "uniprot_id": "LTOR2_HUMAN",
        "mass": 13508.0,
        "length": 125,
        "protein_name": "Ragulator complex protein LAMTOR2",
        "gene_name": "LAMTOR2",
        "organism": "Human",
        "refseq_name": "ragulator complex protein LAMTOR2 isoform 2",
        "refseq_ac": "NP_001138736",
        "gene_names_uniprotkb": "LAMTOR2; HSPC003; MAPBPIP; ROBLD3",
        "gene_names_refseq": "ENDAP; HSPC003; LAMTOR2; MAPBPIP; MAPKSP1AP; ROBLD3; Ragulator2; p14",
        "protein_names_uniprotkb": "Ragulator complex protein LAMTOR2; Endosomal adaptor protein p14; Late endosomal/lysosomal Mp1-interacting protein; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; MAPBP-interacting protein; Mitogen-activated protein-binding protein-interacting protein; Roadblock domain-containing protein 3",
        "protein_names_refseq": "MAPBP-interacting protein; MAPKSP1 adaptor protein; endosomal adaptor protein p14; late endosomal/lysosomal Mp1-interacting protein; late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; mitogen-activated protein-binding protein-interacting protein (MAPBPIP); ragulator complex protein LAMTOR2 isoform 2; ragulator complex protein LAMTOR2; roadblock domain containing 3; roadblock domain-containing protein 3",
        "tax_id": 9606,
        "disease": "primary immunodeficiency syndrome due to p14 deficiency (MONDO:MONDO:0012559)",
        "pathway": " (hsa:28956);  (R-HSA-1632852);  (R-HSA-165159);  (R-HSA-166208);  (R-HSA-380972);  (R-HSA-5628897);  (R-HSA-5674135);  (R-HSA-6798695);  (R-HSA-8943724);  (R-HSA-9639288)",
        "pathway_count": 10,
        "publication_count": 301,
        "publication_id_list": "10209122;10329961;10409742;10654941;10716435;10725339;10745013;10891492;10980602;11018120;11029283;11034341;11096062;11340051;11378386;11486029;11545734;11781575;11802164;11802165;11825910;11959846;12150926;12151408;12161445;12203114;12438239;12453409;12473660;12479806;12524439;12714747;12742462;12805220;12832465;12869586;12906785;13298683;13538944;14511394;14517248;14614828;14636584;14651849;14970219;14985505;15105503;15118098;15187094;15223;15239952;15260967;15314020;15520807;15543157;15547943;15579580;15589136;15755954;15809305;15854902;15878852;16098514;16135787;16140933;16413492;16418168;16636147;16676006;16702404;16728594;16760263;16839880;16879721;16943194;16963840;1715244;17178906;17195838;17277771;17298220;17386266;17470430;17486094;17496912;17510057;17517883;17540029;17563371;17618624;17873065;17897319;17974977;18172008;18198340;18321988;18344994;18372248;18391013;18439900;18487508;18497260;18604198;18692468;19091303;19113821;19211835;19219045;19242111;19279408;19322194;19439913;19440552;19487573;19590496;19822145;19855179;19884659;19898463;20059746;20080666;20182617;20233713;20351271;20378837;20381137;20516213;20713597;20858867;20921139;21177865;21205641;21258367;21289308;21383122;21460621;21602892;21750704;21779496;21819378;21829671;21958598;22053050;22128185;22170151;22177953;22363791;22569528;22575674;22682742;22980980;23202584;23287862;23481700;23614898;23650620;23667175;23685627;23723238;23727157;23775793;23884233;23934108;24066844;24081491;24095279;24366874;24383451;24715725;24718924;24746704;24747438;24937142;24954904;25195011;25259925;25263562;25313996;25435214;25457612;25484072;25561175;25567906;25568151;25576301;25579166;25645385;25728608;25819761;25892735;25961827;25963655;26154972;26449471;26586190;26652033;26910647;26972053;27227380;27308486;27487210;27648300;27846572;27862975;28066558;28199306;28199315;28228285;28832583;28904123;28935770;28939558;29053970;29056322;29107538;29123071;29123114;29158492;29236692;29242379;29285400;29331515;29467321;29508533;29557506;29769354;29789417;30034615;30061680;30181260;30192525;30315122;30484775;30651352;30794926;31217245;31601708;31672913;31704029;31844290;31848261;31937595;32157095;32161166;32350084;32357974;32387766;32502341;32868926;3287375;32938616;32983136;33123756;33141586;33298915;33392160;33717175;33936100;33968037;34087483;34171305;34211107;34357683;34509645;34932366;35051231;35058442;35251023;35318648;35338845;35561310;35580925;36010968;36103527;36215666;36241641;36581221;36697823;37626304;37938771;5666113;7499430;7565670;7565795;7628435;7731720;7929275;7935411;7979252;7989588;8051079;8119488;8157000;8549768;8692836;8779952;9020159;9721431;9733512;9858547;9926927",
        "class_list": "",
        "function": "A complex encoded by the MAPKSP1, ROBLD3, and c11orf59 genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation, [RefSeq, PubMed]; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22053050, PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29158492, PubMed:30181260). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:29107538, PubMed:29123114, PubMed:29158492). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Simulations constitute a multi-dimensional exploration of how EGF-dependent EGFR endocytosis and ERK activation are dynamically affected by scaffolds KSR and MP1, co-regulated by Cbl-CIN85 and Endophilin A1, [RefSeq, PubMed]; The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]., [RefSeq]; VSIG2 promotes malignant progression of pancreatic ductal adenocarcinoma by enhancing LAMTOR2-mediated mTOR activation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
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        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VY97;Q5VY98;Q5VY99",
        "ec_number_list": "",
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0035579 specific granule membrane;GO:0070821 tertiary granule membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane",
        "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0001558 regulation of cell growth;GO:0032008 positive regulation of TOR signaling;GO:0008104 intracellular protein localization;GO:0038202 TORC1 signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 30.2,
        "record_id": "Q9Y2Q5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q66K41-1",
        "uniprot_id": "Z385C_HUMAN",
        "mass": 44149.0,
        "length": 422,
        "protein_name": "Zinc finger protein 385C",
        "gene_name": "ZNF385C",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "ZNF385C",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Zinc finger protein 385C",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 10,
        "publication_id_list": "11237011;29242379;29557506;30379171;30524438;32938616;33141586;33912179;34171305;35494241",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 2,
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        "reported_fully_resolved_glycans": 1,
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        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WX54;Q4G0J1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q66K41-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92567-1",
        "uniprot_id": "F168A_HUMAN",
        "mass": 26184.0,
        "length": 244,
        "protein_name": "Protein FAM168A",
        "gene_name": "FAM168A",
        "organism": "Human",
        "refseq_name": "protein FAM168A isoform 1",
        "refseq_ac": "NP_001272979",
        "gene_names_uniprotkb": "FAM168A; KIAA0280; TCRP1",
        "gene_names_refseq": "FAM168A; KIAA0280; TCRP1",
        "protein_names_uniprotkb": "Protein FAM168A; Tongue cancer chemotherapy resistance-associated protein 1",
        "protein_names_refseq": "protein FAM168A isoform 1; protein FAM168A; tongue cancer chemotherapy resistance-associated protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23201)",
        "pathway_count": 1,
        "publication_count": 65,
        "publication_id_list": "10.1101/2023.09.13.557529;21334329;21603883;22771904;23251525;23481700;24715725;25260657;25576301;25892735;26154972;26375851;26992070;27600516;27846572;28314751;28832583;28834231;28859669;28904123;29242379;29314611;29393594;29508533;29557506;29769354;29786170;29789417;30315122;30429286;30484775;31154438;31217245;31291942;31844290;31848261;32157095;32161166;32323833;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33537174;33592498;33717175;33912179;33968037;34087483;34171305;34185709;35051231;35318648;35580925;36010968;36215666;36241641;36284347;37938771;38665916;39302247",
        "class_list": "",
        "function": "Data suggest that TCRP1 (EF363480) might be a novel molecular target to develop agents to reverse cisplatin-induced chemoresistance., [RefSeq, PubMed]; FAM168A involved in the regulation of AKT1/NFkappaB signaling pathway and cell cycle in chronic myeloid leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; In cancer context, decreases POLB ubiquitination and stabilizes its protein levels (PubMed:25260657). Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation (PubMed:23251525, PubMed:25260657). Results in protection of cells from induced-DNA damage and apoptosis (PubMed:21334329, PubMed:23251525, PubMed:25260657)., [UniProtKB, PubMed, PubMed, PubMed]; Our results highlight that hyper-methylation of miR-493CpG island might play important roles in the development of lung cancer chemo-resistance by targeting TCRP1, which might be used as a potential therapeutic target in preventing the chemo-resistance of lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; SiRNA-mediated knockdown of TCRP1 and MT1X was found to sensitize cells to cisplatin, leading to increased apoptosis and inhibition of cell proliferation, [RefSeq, PubMed]; TCRP1 induces tamoxifen resistance by promoting the activation of SGK1 in MCF7 cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
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        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2ICY2;A2ID81;Q86UG2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:1905053 positive regulation of base-excision repair",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q92567-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P21145-1",
        "uniprot_id": "MAL_HUMAN",
        "mass": 16714.0,
        "length": 153,
        "protein_name": "Myelin and lymphocyte protein",
        "gene_name": "MAL",
        "organism": "Human",
        "refseq_name": "myelin and lymphocyte protein isoform a",
        "refseq_ac": "NP_002362",
        "gene_names_uniprotkb": "MAL",
        "gene_names_refseq": "HLD28; MAL; MVP17; VIP17",
        "protein_names_uniprotkb": "Myelin and lymphocyte protein; T-lymphocyte maturation-associated protein",
        "protein_names_refseq": "T-lymphocyte maturation-associated protein; mal, T-cell differentiation protein; myelin and lymphocyte protein isoform a; myelin and lymphocyte protein",
        "tax_id": 9606,
        "disease": "metachromatic leukodystrophy (Disease Ontology:DOID:10581); leukodystrophy, hypomyelinating, 28 (MONDO:MONDO:0975833)",
        "pathway": " (hsa:4118)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "24366607;29242379;29557506;29789417;31844290;32350084;33345332;34561969;3494249;35093120;35217805;38461243;38678596;8088843;8132541",
        "class_list": "",
        "function": "Differentiation and activation of human CD4 T cells is associated with a gradual loss of myelin and lymphocyte protein., [RefSeq, PubMed]; MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2. Publication Status: Online-Only, [RefSeq, PubMed]; MAL protein suppresses the metastasis and invasion of GC cells by interfering with the phosphorylation of STAT3. Publication Status: Online-Only, [RefSeq, PubMed]; MAL, a potential immunotherapy target, is associated with poor prognosis in cancer patients. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in vesicular trafficking from the Golgi apparatus to the cell membrane. Plays a role in the maintenance of the myelin sheath, and in axon-glia and glia-glia interactions., [UniProtKB, UniProtKB]; The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
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        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6FH77",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019911 structural constituent of myelin sheath;GO:0008289 lipid binding;GO:0016505 peptidase activator activity involved in apoptotic process",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0044853 plasma membrane raft;GO:0045121 membrane raft;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0030154 cell differentiation;GO:0006915 apoptotic process;GO:0042552 myelination;GO:0007417 central nervous system development;GO:0001766 membrane raft polarization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "P21145-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13496-1",
        "uniprot_id": "MTM1_HUMAN",
        "mass": 69932.0,
        "length": 603,
        "protein_name": "Myotubularin",
        "gene_name": "MTM1",
        "organism": "Human",
        "refseq_name": "myotubularin isoform 1",
        "refseq_ac": "NP_000243",
        "gene_names_uniprotkb": "MTM1; CG2",
        "gene_names_refseq": "CNMX; CNM; MTM1; MTMX; XLMTM",
        "protein_names_uniprotkb": "Myotubularin; 3.1.3.95; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase",
        "protein_names_refseq": "myotubularin isoform 1; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase",
        "tax_id": 9606,
        "disease": "Charcot-Marie-Tooth disease type 4B1 (Disease Ontology:DOID:0110191); centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); centronuclear myopathy (Disease Ontology:DOID:14717); congenital structural myopathy (Disease Ontology:DOID:422); myopathy (Disease Ontology:DOID:423)",
        "pathway": " (hsa:4534);  (R-HSA-1660499);  (R-HSA-1660516);  (R-HSA-1660517)",
        "pathway_count": 4,
        "publication_count": 190,
        "publication_id_list": "10063835;10194451;10224048;10419465;10466421;10502779;10555148;10559940;10593988;10753883;10766823;10790201;10805725;10822173;10900271;11001876;11001925;11084340;11237011;11279162;11302699;11349134;11604140;11676921;11706043;11733541;11793470;11877430;11923287;12031625;12101241;12118066;12270933;12324459;12422219;12522554;12536145;12646134;12808147;12847086;12847286;12859411;12890864;14516276;14617813;14660569;14722070;15080793;15107860;15135396;15464023;15716355;15797027;15840652;16154996;16399794;16476736;16522682;1655747;16787938;16914545;16964243;16979564;17005396;17008356;17081983;17245604;17556371;17651088;18088087;18093523;18524850;18669648;18753295;18950639;19038970;19129059;19896968;20068231;20166139;20534812;21081650;21135508;21204784;22037487;22647598;23186163;23481700;23519112;23758345;23818870;24715725;25087613;25495341;25576301;25645385;25869668;26154972;26375851;26496610;26992070;27397612;27600516;27846572;27862975;27893789;28063628;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29493099;29557506;29632711;29786170;29789417;30315122;30410026;30429286;30484775;30779550;30833945;30884204;31092671;31154438;31217245;31541013;31844290;31848261;32157095;32161166;32265295;32357974;32387766;32439798;32488085;32502341;32805447;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33912179;33936100;33968037;34171305;34185709;35051231;35177076;35580925;36010968;36241641;37139790;37938771;7608176;7624799;7628435;8640223;8681945;8723348;8769125;8999962;9094719;9113989;9211928;9285787;9286278;9295334;9305655;9367159;9428629;9514948;9516481;9524259;9537414;9593664;9660759;9660833;9781038;9811831;9829274;9830063",
        "class_list": "",
        "function": "BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes., [RefSeq, PubMed]; Circ_FURIN knockdown assuages Testosterone-induced human ovarian granulosa-like tumor cell disorders by sponging miR-423-5p to reduce MTM1 expression in polycystic ovary syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PubMed:10900271, PubMed:11001925, PubMed:12646134, PubMed:14722070). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414). Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070). Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508). Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MTM1 mutation is related to myopathy, [RefSeq, PubMed]; Myotubularin loss-of-function mutations cause X-linked myotubular myopathy, a severe congenital myoopathy with predominance and hypotrophy of type I (slow) muscle fibers, [RefSeq, PubMed]; This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. [provided by RefSeq, Jul 2008]., [RefSeq]; Three novel mutations in the second cluster of PTP domain in MTM1 were identified in 3 patients with X-linked myotubular myopathy., [RefSeq, PubMed]; X-linked myotubular myopathy mimics hereditary spastic paraplegia in two female manifesting carriers of pathogenic MTM1 variant., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "reported_phosphosites": 9,
        "reported_mutagensis": 18,
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        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "A6NDB1;B7Z491;F2Z330;Q8NEL1",
        "ec_number_list": "3.1.3.-;3.1.3.95;3.1.3.36;3.1.3.64;3.1.3.67;3.1.3.86",
        "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0004721 phosphoprotein phosphatase activity;GO:0019215 intermediate filament binding;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005770 late endosome",
        "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0015031 protein transport;GO:0046716 muscle cell cellular homeostasis;GO:0008333 endosome to lysosome transport;GO:0006470 protein dephosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 19.1,
        "record_id": "Q13496-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P15173-1",
        "uniprot_id": "MYOG_HUMAN",
        "mass": 25037.0,
        "length": 224,
        "protein_name": "Myogenin",
        "gene_name": "MYOG",
        "organism": "Human",
        "refseq_name": "myogenin",
        "refseq_ac": "NP_002470",
        "gene_names_uniprotkb": "MYOG; BHLHC3; MYF4",
        "gene_names_refseq": "MYF4; MYOG; bHLHc3; myf-4",
        "protein_names_uniprotkb": "Myogenin; Class C basic helix-loop-helix protein 3; Myf-4; Myogenic factor 4; bHLHc3",
        "protein_names_refseq": "class C basic helix-loop-helix protein 3; myogenic factor 4; myogenin",
        "tax_id": 9606,
        "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:4656);  (R-HSA-525793);  (R-HSA-9839394);  (R-HSA-9943411)",
        "pathway_count": 4,
        "publication_count": 37,
        "publication_id_list": "10199952;10330143;10601328;10805738;11782431;12634428;12682017;15647753;16263726;16372014;1659574;17433364;17717186;18042460;18299279;19564926;20160094;20211137;22046413;22569126;22922743;24860983;2583111;27661449;30467960;31409900;32060262;32387766;32639872;33743352;37222488;7925980;9069290;9418854;9786951;9858528;9988769",
        "class_list": "",
        "function": "Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Also cooperates with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Also plays a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity)., [UniProtKB]; CASZ1 plays a critical role in inducing skeletal myogenesis and co-operating to form a feed-forward loop with MYOD and MYOG that is critical for Embryonal rhabdomyosarcoma differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Dual-specificity phosphatase 29 is induced during neurogenic skeletal muscle atrophy and attenuates glucocorticoid receptor activity in muscle cell culture., [RefSeq, PubMed]; Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]., [RefSeq]; Myogenin suppresses apoptosis induced by angiotensin II in human induced pluripotent stem cell-derived cardiomyocytes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53XW6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0032993 protein-DNA complex",
        "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0014891 striated muscle atrophy;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "P15173-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16795-1",
        "uniprot_id": "NDUA9_HUMAN",
        "mass": 42510.0,
        "length": 377,
        "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial",
        "gene_name": "NDUFA9",
        "organism": "Human",
        "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor",
        "refseq_ac": "NP_004993",
        "gene_names_uniprotkb": "NDUFA9; NDUFS2L",
        "gene_names_refseq": "CC6; CI-39k; CI39k; COQ11; MC1DN26; NDUFA9; NDUFS2L; SDR22E1",
        "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; CI-39kD; Complex I-39kD; NADH-ubiquinone oxidoreductase 39 kDa subunit",
        "protein_names_refseq": "CI-39kD; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa; NADH dehydrogenase (ubiquinone) Fe-S protein 2-like (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor; NADH-ubiquinone oxidoreductase 39 kDa subunit; complex I 39kDa subunit; short chain dehydrogenase/reductase family 22E, member 1",
        "tax_id": 9606,
        "disease": "nuclear type mitochondrial complex I deficiency 26 (Disease Ontology:DOID:0112086)",
        "pathway": " (hsa:4704);  (R-HSA-611105);  (R-HSA-6799198)",
        "pathway_count": 3,
        "publication_count": 103,
        "publication_id_list": "10327278;11220739;11237011;11695836;12231006;12611891;12837546;1327877;14741580;15250827;16230336;17033964;17936786;1832859;186667;19752196;20406883;20552642;20858599;21924235;22114105;22309213;23150584;23270816;23553477;23564345;23747254;239860;24191001;25418920;25564869;25645385;25678554;26154972;26768311;26811146;26929215;26992070;27452731;27499296;27626371;27846572;27920218;28218747;28228285;28510447;28671271;28832583;28834231;28904123;28985504;29242379;29393594;29557506;29632046;29632711;29769354;29786170;30315122;30484775;30779550;31217245;31530632;31536960;31611695;31666358;31844290;31866046;32157095;32161166;32265295;32320651;32357974;32938616;33141586;33298915;33592498;33879611;33882309;33912179;33936100;33968037;33981976;34357683;34561969;34932366;35051231;35318648;35333655;35614220;36010968;36215666;36241641;36939934;37938771;38199007;38665916;40914422;4288886;8012384;8486360;9571201;9878551",
        "class_list": "",
        "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Required for proper complex I assembly (PubMed:28671271). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed, PubMed, PubMed]; Additive effect of DNAJC30 and NDUFA9 mutations causing Leigh syndrome., [RefSeq, PubMed]; Study identifies mitochondrial transit peptide and determines mature protein cleavage site in cow ortholog., [RefSeq, PubMed]; The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. A pseudogene has been identified on chromosome 12. [provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14076;Q2NKX0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0044877 protein-containing complex binding;GO:0008137 NADH dehydrogenase (ubiquinone) activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane",
        "go_biological_process": "GO:0007623 circadian rhythm;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0006744 ubiquinone biosynthetic process;GO:0006814 sodium ion transport;GO:0042776 proton motive force-driven mitochondrial ATP synthesis",
        "synthesized_glycan_count": 0,
        "hit_score": 10.6,
        "record_id": "Q16795-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UBV8-1",
        "uniprot_id": "PEF1_HUMAN",
        "mass": 30381.0,
        "length": 284,
        "protein_name": "Peflin",
        "gene_name": "PEF1",
        "organism": "Human",
        "refseq_name": "peflin isoform 1",
        "refseq_ac": "NP_036524",
        "gene_names_uniprotkb": "PEF1; ABP32; PRO3573",
        "gene_names_refseq": "ABP32; PEF1A; PEF1",
        "protein_names_uniprotkb": "Peflin; PEF protein with a long N-terminal hydrophobic domain; Penta-EF hand domain-containing protein 1",
        "protein_names_refseq": "PEF protein with a long N-terminal hydrophobic domain; epididymis secretory sperm binding protein; peflin isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:553115)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "10486255;11278427;11883899;12975309;19531498;23301498;25880248;25892735;27716508;28218747;28467828;28832583;28904123;29242379;29557506;30429286;31844290;32983136;33912179;34019948;34357683;35051231;35154160;35580925;37938771;38665916",
        "class_list": "",
        "function": "Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium (PubMed:27716508). Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (PubMed:11278427). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Peflin is stabilized by dimerization through its fifth EF-hand region, [RefSeq, PubMed]; This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. The encoded protein has been shown to form a heterodimer with the programmed cell death 6 gene product and may modulate its function in Ca(2+) signaling. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 1.[provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0046983 protein dimerization activity;GO:0048306 calcium-dependent protein binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0031463 Cul3-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0014029 neural crest formation;GO:0051592 response to calcium ion;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0014032 neural crest cell development;GO:0048208 COPII vesicle coating",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q9UBV8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96S44-1",
        "uniprot_id": "PRPK_HUMAN",
        "mass": 28160.0,
        "length": 253,
        "protein_name": "EKC/KEOPS complex subunit TP53RK",
        "gene_name": "TP53RK",
        "organism": "Human",
        "refseq_name": "EKC/KEOPS complex subunit TP53RK",
        "refseq_ac": "NP_291028",
        "gene_names_uniprotkb": "TP53RK; C20orf64; PRPK",
        "gene_names_refseq": "BUD32; C20orf64; GAMOS4; Nori-2p; Nori-2; PRPK; TP53RK; TPRKB; dJ101A2",
        "protein_names_uniprotkb": "EKC/KEOPS complex subunit TP53RK; 2.7.11.1; 3.6.-.-; Atypical serine/threonine protein kinase TP53RK; Nori-2; TP53-regulating kinase; p53-related protein kinase",
        "protein_names_refseq": "EKC/KEOPS complex subunit TP53RK; atypical serine/threonine protein kinase TP53RK; p53-related protein kinase",
        "tax_id": 9606,
        "disease": "Galloway-Mowat syndrome 4 (Disease Ontology:DOID:0080246)",
        "pathway": " (hsa:112858);  (R-HSA-6782315);  (R-HSA-6804756)",
        "pathway_count": 3,
        "publication_count": 123,
        "publication_id_list": "10430867;10435622;10500146;10570149;10604467;10673500;10673501;10710310;10884347;10982862;11027153;11111046;11237011;11239457;11447225;11511362;11546806;11551930;11740489;11780126;12064478;12393879;12403464;12659830;12702766;12851404;12914926;14702041;15053879;15861136;15866171;15870694;15994936;16043508;16322561;16424344;16600182;17071714;17108107;17344846;17349958;17591690;17712528;18490454;18567810;18691976;19017811;19121998;19369195;19414587;19965871;20123966;20308323;20354154;20584901;20959462;21059936;21131277;21317932;22344696;22591353;22912744;22995836;23000554;23042678;23048041;23381944;23485397;23604283;23676219;24126054;24145406;24204302;24874608;24901367;25261850;25404562;25418920;25576301;25880248;25916855;26154972;26160102;26310293;26375851;26992070;27055666;27846572;27903914;28412249;28510447;28805828;28832583;28834231;28904123;29242379;29393594;29632046;30429286;31154438;31481669;31844290;31848261;32157095;32350084;32357974;32938616;33298915;33547416;33912179;33981976;34229054;34561969;34932366;35154160;35318648;35580925;36241641;36610787;37382161;9430663;9851972;9925639",
        "class_list": "",
        "function": "A Small Ras-like GTPase protein Ray was indicated to modulate p53 transcriptional activity of PRPK., [RefSeq, PubMed]; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Crystal structure of the human PRPK-TPRKB complex. Publication Status: Online-Only, [RefSeq, PubMed]; TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KU44;Q3T977;Q5JZ01;Q6NZ60;Q96FM7;Q9NQE6",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.3.1.234;2.7.1.150",
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0002039 p53 binding;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000408 EKC/KEOPS complex",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0008033 tRNA processing;GO:1901796 regulation of signal transduction by p53 class mediator;GO:1990145 maintenance of translational fidelity;GO:0070525 tRNA threonylcarbamoyladenosine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "Q96S44-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P98168-1",
        "uniprot_id": "ZXDA_HUMAN",
        "mass": 84771.0,
        "length": 799,
        "protein_name": "Zinc finger X-linked protein ZXDA",
        "gene_name": "ZXDA",
        "organism": "Human",
        "refseq_name": "zinc finger X-linked protein ZXDA",
        "refseq_ac": "NP_009087",
        "gene_names_uniprotkb": "ZXDA",
        "gene_names_refseq": "ZNF896; ZXDA",
        "protein_names_uniprotkb": "Zinc finger X-linked protein ZXDA",
        "protein_names_refseq": "zinc finger X-linked protein ZXDA; zinc finger protein 896",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7789)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "16964243;17493635;19007248;19777325;25645385;26566883;27846572;27862975;28228285;28832583;28834231;29393594;30484775;31154438;31844290;32157095;32938616;34087483;35051231;35580925;36010968;36241641;8268913",
        "class_list": "",
        "function": "Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes., [UniProtKB, PubMed]; Role of ZXD proteins in regulating MHC II transcription., [RefSeq, PubMed]; This gene encodes one of two duplicated zinc finger genes on chromosome Xp11. This gene is the telomeric copy; GeneID 158586 ZXDB is the more centromeric copy. The two genes have 98% nucleotide sequence similarity, and the predicted proteins contain 10 tandem zinc finger motifs. [provided by RefSeq, Nov 2009]., [RefSeq]; ZXDA and ZXDC form an important regulatory complex for MHC II gene transcription., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UJP7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0070742 C2H2 zinc finger domain binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "P98168-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q2QGD7-1",
        "uniprot_id": "ZXDC_HUMAN",
        "mass": 89988.0,
        "length": 858,
        "protein_name": "Zinc finger protein ZXDC",
        "gene_name": "ZXDC",
        "organism": "Human",
        "refseq_name": "zinc finger protein ZXDC isoform 2",
        "refseq_ac": "NP_001035743",
        "gene_names_uniprotkb": "ZXDC; ZXDL",
        "gene_names_refseq": "ZXDC; ZXDL",
        "protein_names_uniprotkb": "Zinc finger protein ZXDC; ZXD-like zinc finger protein",
        "protein_names_refseq": "SERH2790; ZXD-like zinc finger protein; zinc finger protein ZXDC isoform 2; zinc finger protein ZXDC",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79364)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "11237011;16600381;17493635;17696781;19777325;23186163;24275569;24715725;25505266;25576301;25880248;26811146;26992070;27600516;27846572;28832583;28834231;28904123;29242379;29393594;29493099;29557506;29786170;30379171;30429286;31154438;31844290;31848261;32157095;32357974;32387766;32488085;32897882;32938616;33141586;33298915;33592498;33717175;33968037;33981976;34087483;34171305;34509645;35051231;35494241;35580925;36010968;36215666;36241641;36284347;36497052",
        "class_list": "",
        "function": "CircZXDC Promotes Vascular Smooth Muscle Cell Transdifferentiation via Regulating miRNA-125a-3p/ABCC6 in Moyamoya Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Role of ZXD proteins in regulating MHC II transcription., [RefSeq, PubMed]; Study found sumoylation does not appear to disrupt or modulate interaction of ZXDC with binding partners; sumoylation of ZXDC is required for full activity of transcriptional activation domain; study suggests sumoylation is an important regulator of ZXDC, [RefSeq, PubMed]; ZXDA and ZXDC form an important regulatory complex for MHC II gene transcription., [RefSeq, PubMed]; ZXDC is an important regulator of both MHC class I and class II transcription, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C5J0H9;Q6DKI8;Q7L3L1;Q8NAU2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0030275 LRR domain binding;GO:0070742 C2H2 zinc finger domain binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q2QGD7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WX92-2",
        "uniprot_id": "NELFB_HUMAN",
        "mass": 70057.0,
        "length": 628,
        "protein_name": "Negative elongation factor B",
        "gene_name": "NELFB",
        "organism": "Human",
        "refseq_name": "negative elongation factor B",
        "refseq_ac": "NP_056271",
        "gene_names_uniprotkb": "NELFB; COBRA1; KIAA1182",
        "gene_names_refseq": "COBRA1; NELF-B; NELFB",
        "protein_names_uniprotkb": "Negative elongation factor B; Cofactor of BRCA1; NELF-B",
        "protein_names_refseq": "cofactor of BRCA1; negative elongation factor B; negative elongation factor protein B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25920);  (R-HSA-112382);  (R-HSA-113418);  (R-HSA-167152);  (R-HSA-167158);  (R-HSA-167200);  (R-HSA-167238);  (R-HSA-167242);  (R-HSA-167243);  (R-HSA-167246);  (R-HSA-167287);  (R-HSA-167290);  (R-HSA-674695);  (R-HSA-6796648);  (R-HSA-75955);  (R-HSA-9603505)",
        "pathway_count": 16,
        "publication_count": 62,
        "publication_id_list": "10199401;10757782;10866664;10916156;10984493;11230166;11313498;11313499;11350971;11739404;11859374;11884399;11971958;11988847;12370301;12612062;12653964;12676794;14701750;15489290;15781865;17234882;18669648;1939271;19608861;19690332;19952111;20068231;20159561;21153684;22012619;22988298;23186163;23538671;23884411;24275569;24354960;2449431;24554720;24662513;25429106;25561469;25712099;26010750;26659056;2825027;34019948;34705606;37591184;38253038;40596516;40914422;7660122;7660129;7660130;7853496;8370526;9063748;9450929;9489704;9765293;9857195",
        "class_list": "",
        "function": "(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II (PubMed:23884411). In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1 (PubMed:23884411)., [UniProtKB, PubMed]; Both human and mouse NELF-B proteins are translated from a non-AUG codon upstream of the annotated AUG. Publication Status: Online-Only, [RefSeq, PubMed]; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]., [RefSeq]; NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to temozolomide (TMZ) via NELFB and RPS6KB2 interaction., [RefSeq, PubMed]; Structural basis of the human negative elongation factor NELF-B/C/E ternary complex., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0X1KG71;A2BFA3;Q96EW5;Q9H9R4;Q9ULN8;Q9Y3W0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0032021 NELF complex",
        "go_biological_process": "GO:0008283 cell population proliferation;GO:0048863 stem cell differentiation;GO:0034244 negative regulation of transcription elongation by RNA polymerase II;GO:2000737 negative regulation of stem cell differentiation;GO:0160239 transcription pausing by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q8WX92-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z7H3-1",
        "uniprot_id": "CATIP_HUMAN",
        "mass": 43900.0,
        "length": 387,
        "protein_name": "Ciliogenesis-associated TTC17-interacting protein",
        "gene_name": "CATIP",
        "organism": "Human",
        "refseq_name": "ciliogenesis-associated TTC17-interacting protein isoform 1",
        "refseq_ac": "NP_001307794",
        "gene_names_uniprotkb": "CATIP; C2orf62",
        "gene_names_refseq": "C2orf62; CATIP",
        "protein_names_uniprotkb": "Ciliogenesis-associated TTC17-interacting protein",
        "protein_names_refseq": "ciliogenesis-associated TTC17-interacting protein isoform 1",
        "tax_id": 9606,
        "disease": "spermatogenic failure 54 (Disease Ontology:DOID:0112335)",
        "pathway": " (hsa:375307)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;24475127;24715725;32503832;33298915;33912179;39894887",
        "class_list": "",
        "function": "Plays a role in primary ciliogenesis by modulating actin polymerization., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0030041 actin filament polymerization;GO:0044782 cilium organization;GO:0030030 cell projection organization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q7Z7H3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00305-1",
        "uniprot_id": "CACB4_HUMAN",
        "mass": 58169.0,
        "length": 520,
        "protein_name": "Voltage-dependent L-type calcium channel subunit beta-4",
        "gene_name": "CACNB4",
        "organism": "Human",
        "refseq_name": "voltage-dependent L-type calcium channel subunit beta-4 isoform b",
        "refseq_ac": "NP_000717",
        "gene_names_uniprotkb": "CACNB4; CACNLB4",
        "gene_names_refseq": "CAB4; CACNB4; CACNLB4; EA5; EIG9; EJM4; EJM6; EJM",
        "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit beta-4; CAB4; Calcium channel voltage-dependent subunit beta 4",
        "protein_names_refseq": "calcium channel voltage-dependent subunit beta 4; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; voltage-dependent L-type calcium channel subunit beta-4 isoform b; voltage-dependent L-type calcium channel subunit beta-4",
        "tax_id": 9606,
        "disease": "episodic ataxia type 5 (Disease Ontology:DOID:0050993); obsolete idiopathic generalized epilepsy 9 (Disease Ontology:DOID:0111323); dilated cardiomyopathy (Disease Ontology:DOID:12930); generalized epilepsy (Disease Ontology:DOID:1827); episodic ataxia (Disease Ontology:DOID:963)",
        "pathway": " (hsa:785);  (R-HSA-112308);  (R-HSA-419037)",
        "pathway_count": 3,
        "publication_count": 41,
        "publication_id_list": "10762541;11237011;11880487;12765789;16267048;16385006;17618603;18059411;19807924;22544926;23481700;26375851;26992070;27920218;28063628;2809592;28411811;29393594;29557506;29786170;31844290;32176688;32350084;32387766;32502341;32897882;32938616;33141586;33936100;33968037;34171305;34405274;34509645;35051231;36010968;36241641;8262246;8825650;9254841;9398268;9628818",
        "class_list": "",
        "function": "Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The homozygous CACNB4 p.(Leu126Pro) variant underlies the severe neurological phenotype in the two siblings. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE), juvenile myoclonic epilepsy (JME), and episodic ataxia, type 5. [provided by RefSeq, Aug 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7BJ74;A8K1Y4;B4DG40;O60515;Q6B000;Q96L40",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0005246 calcium channel regulator activity;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:0008331 high voltage-gated calcium channel activity;GO:0005245 voltage-gated calcium channel activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0045202 synapse",
        "go_biological_process": "GO:0045933 positive regulation of muscle contraction;GO:0008285 negative regulation of cell population proliferation;GO:0006816 calcium ion transport;GO:0007268 chemical synaptic transmission;GO:0070588 calcium ion transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "O00305-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P61088-1",
        "uniprot_id": "UBE2N_HUMAN",
        "mass": 17138.0,
        "length": 152,
        "protein_name": "Ubiquitin-conjugating enzyme E2 N",
        "gene_name": "UBE2N",
        "organism": "Human",
        "refseq_name": "ubiquitin-conjugating enzyme E2 N",
        "refseq_ac": "NP_003339",
        "gene_names_uniprotkb": "UBE2N; BLU",
        "gene_names_refseq": "HEL-S-71; UBC13; UBCHBEN; UBE2N; UbcH-ben; UbcH13",
        "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 N; 2.3.2.23; Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; Ubc13; UbcH13; Ubiquitin carrier protein N; Ubiquitin-protein ligase N",
        "protein_names_refseq": "E2 ubiquitin-conjugating enzyme N; bendless-like ubiquitin conjugating enzyme; epididymis secretory protein Li 71; ubiquitin carrier protein N; ubiquitin conjugating enzyme E2N; ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); ubiquitin-protein ligase N; yeast UBC13 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7334);  (R-HSA-1169408);  (R-HSA-168638);  (R-HSA-168927);  (R-HSA-202424);  (R-HSA-2871837);  (R-HSA-445989);  (R-HSA-450302);  (R-HSA-450321);  (R-HSA-5205685);  (R-HSA-5607764);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-5696395);  (R-HSA-69473);  (R-HSA-8866654);  (R-HSA-9020702);  (R-HSA-937039);  (R-HSA-937041);  (R-HSA-9646399);  (R-HSA-9705671);  (R-HSA-975110);  (R-HSA-975144);  (R-HSA-983168)",
        "pathway_count": 25,
        "publication_count": 621,
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        "class_list": "",
        "function": "SET7 methylates the deubiquitinase OTUB1 at Lys [122] to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis., [RefSeq, PubMed]; Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta., [RefSeq, PubMed]; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175, PubMed:31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]., [RefSeq]; UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16781;Q53Y81",
        "ec_number_list": "6.2.1.45;2.3.2.24;2.3.2.23;2.7.12.2;2.7.11.10;2.7.11.1;2.3.2.26;2.3.2.27;2.7.11.25;2.7.10.2;2.3.2.31;1.14.11.69;1.14.11.66;2.3.2.-;3.6.5.-;2.1.1.357;2.4.2.-;2.4.2.30;4.2.99.18;5.6.2.4;5.6.1.6;5.6.2.3;6.2.1.-;3.4.19.-;3.1.-.-;3.1.3.16;1.14.11.-;2.3.2.34;2.3.2.32;2.7.11.13;6.3.2.n3;3.6.4.-;6.2.1.64;3.6.-.-;2.3.1.48;2.3.1.-;2.3.2.25;2.3.2.36;3.1.2.-;3.5.1.-;3.5.1.124;3.4.22.-;3.4.19.12",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0043130 ubiquitin binding",
        "go_cellular_component": "GO:0031371 ubiquitin conjugating enzyme complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045739 positive regulation of DNA repair;GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 62.4,
        "record_id": "P61088-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UHB6-1",
        "uniprot_id": "LIMA1_HUMAN",
        "mass": 85226.0,
        "length": 759,
        "protein_name": "LIM domain and actin-binding protein 1",
        "gene_name": "LIMA1",
        "organism": "Human",
        "refseq_name": "LIM domain and actin-binding protein 1 isoform 1",
        "refseq_ac": "NP_001107018",
        "gene_names_uniprotkb": "LIMA1; EPLIN; PP624; SREBP3",
        "gene_names_refseq": "EPLIN; LDLCQ8; LIMA1; SREBP3",
        "protein_names_uniprotkb": "LIM domain and actin-binding protein 1; Epithelial protein lost in neoplasm",
        "protein_names_refseq": "LIM domain and actin-binding protein 1 isoform 1; epithelial protein lost in neoplasm beta; sterol regulatory element binding protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51474)",
        "pathway_count": 1,
        "publication_count": 129,
        "publication_id_list": "10618726;10806352;10931946;11230166;11237011;11256614;12566430;15302935;15498874;16083285;16565220;17081983;17287340;17322306;17924679;18077418;18088087;18452278;18491316;18578522;18669648;18691976;18707149;18767875;19007248;19413330;19415658;19562805;19651622;19664995;19690332;19691289;20068230;20068231;20112406;20166139;21406692;23186163;23188829;23301498;23481700;23719902;23783831;24275569;24366607;24694988;24714562;24715725;25418920;25576301;25645385;25880248;26154972;26375851;26728094;26992070;27397612;27600516;27846572;27862975;27920218;28649982;28832583;28834231;28904123;29237092;29242379;29393594;29493099;29508533;29557506;29786170;29789417;29880681;30192525;30429286;30484775;30779550;31092671;31154438;31217245;31530632;31844290;31848261;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32496561;32502341;32938616;32983136;33043033;33123756;33141586;33214551;33298915;33465208;33592498;33717175;33912179;33936100;33968037;33981976;33999101;34019948;34211107;34932366;35051231;35251023;35254053;35318648;35513511;35561310;35580925;36284347;37074911;37752233;37938771;38185251;38665916;38719752;39076043;39921472;39990658;40596516",
        "class_list": "",
        "function": "Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Expression and molecular insights of lima1 in cholangiocarcinoma., [RefSeq, PubMed]; MAD2 activates IGF1R/PI3K/AKT pathway and promotes cholangiocarcinoma progression by interfering USP44/LIMA1 complex., [RefSeq, PubMed]; Nuclear-cytoplasmic translocation of SQSTM1/p62 protein enhances ESCC cell migration and invasion by stabilizing EPLIN expression., [RefSeq, PubMed]; The concerted action of SEPT9 and EPLIN modulates the adhesion and migration of human fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "B2RB09;Q2TAN7;Q59FE8;Q9BVF2;Q9H8J1;Q9HBN5;Q9NX96;Q9NXC3;Q9NXU6;Q9P0H8;Q9UHB5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003785 actin monomer binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0045296 cadherin binding;GO:0140778 microtubule stabilizing activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton",
        "go_biological_process": "GO:0030835 negative regulation of actin filament depolymerization;GO:1902018 negative regulation of cilium assembly;GO:0032233 positive regulation of actin filament bundle assembly;GO:0008203 cholesterol metabolic process;GO:0016477 cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 14.9,
        "record_id": "Q9UHB6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q01518-1",
        "uniprot_id": "CAP1_HUMAN",
        "mass": 51901.0,
        "length": 475,
        "protein_name": "Adenylyl cyclase-associated protein 1",
        "gene_name": "CAP1",
        "organism": "Human",
        "refseq_name": "adenylyl cyclase-associated protein 1 isoform a",
        "refseq_ac": "NP_001099000",
        "gene_names_uniprotkb": "CAP1; CAP",
        "gene_names_refseq": "CAP1-PEN; CAP1; CAP",
        "protein_names_uniprotkb": "Adenylyl cyclase-associated protein 1; CAP 1",
        "protein_names_refseq": "CAP, adenylate cyclase-associated protein 1; adenylate cyclase associated protein 1; adenylyl cyclase-associated protein 1 isoform a; adenylyl cyclase-associated protein 1; testis secretory sperm-binding protein Li 218p",
        "tax_id": 9606,
        "disease": "pancreatic cancer (Disease Ontology:DOID:1793)",
        "pathway": " (hsa:10487);  (R-HSA-114608);  (R-HSA-428890);  (R-HSA-6798695)",
        "pathway_count": 4,
        "publication_count": 138,
        "publication_id_list": "10892742;11237011;11950878;12665801;1406678;1435334;14630798;15297306;15311924;16807684;17081983;17924679;18088087;18212344;18491316;18510355;18669648;18991276;19367720;19413330;19415658;19608861;19651622;19690332;20058876;20068231;21406692;22223895;23186163;23481700;23640497;23650620;24129315;24715725;25114211;25502872;25576301;25645385;25880248;26154972;26375851;26758079;26768311;26992070;27452731;27600516;27726376;27862975;27920218;28218747;28228285;28467828;28510447;28832583;28834231;28904123;29242379;29314611;29351928;29393594;29437277;29493099;29508533;29557506;29632711;29774024;29786170;30123351;30315122;30410026;30429286;30573663;30779550;30833945;30894654;31020640;31092671;31154438;31217245;31373491;31530632;31611695;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33465208;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34231097;34357683;34405274;34433824;34509645;34561969;34636991;34725712;34932366;35051231;35138101;35154160;35251023;35561310;35580925;36010968;36215666;36241641;36284347;37217939;37938771;38665916;40307207;40596516;40914422;6457647;8467233;8692836",
        "class_list": "",
        "function": "Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity., [UniProtKB]; Phosphorylation of CAP1 regulates lung cancer proliferation, migration, and invasion., [RefSeq, PubMed]; Plays a key role in speeding up the turnover of actin filaments by effectively recycling cofilin and actin and through its effect on both ends of actin filament, [RefSeq, PubMed]; Serum levels of cytoskeleton remodeling proteins and their mRNA expression in tumor tissue of metastatic laryngeal and hypopharyngeal cancers., [RefSeq, PubMed]; The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]., [RefSeq]",
        "predicted_glycosites": 0,
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        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53HR7;Q5T0S1;Q5T0S2;Q6I9U6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0008179 adenylate cyclase binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion",
        "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0007190 activation of adenylate cyclase activity;GO:0000902 cell morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 14.5,
        "record_id": "Q01518-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "B2RNN3-1",
        "uniprot_id": "C1T9B_HUMAN",
        "mass": 34713.0,
        "length": 333,
        "protein_name": "Complement C1q and tumor necrosis factor-related protein 9B",
        "gene_name": "C1QTNF9B",
        "organism": "Human",
        "refseq_name": "complement C1q and tumor necrosis factor-related protein 9B precursor",
        "refseq_ac": "NP_001007538",
        "gene_names_uniprotkb": "C1QTNF9B",
        "gene_names_refseq": "C1QTNF9B; CTRP9B",
        "protein_names_uniprotkb": "Complement C1q and tumor necrosis factor-related protein 9B; C1q/TNF-related protein 9B; CTRP9B; Complement C1q and tumor necrosis factor-related protein 9-like",
        "protein_names_refseq": "C1q and tumor necrosis factor related protein 9B; C1q/TNF-related protein 9B; collagen triple helix repeat-containing; complement C1q and tumor necrosis factor-related protein 9B precursor; complement C1q and tumor necrosis factor-related protein 9B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:387911)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;19666007;34514937",
        "class_list": "",
        "function": "C1q/TNF-related protein-9 suppresses inflammation in synovial cells from patients with osteoarthritis., [RefSeq, PubMed]; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways., [UniProtKB, UniProtKB]; Two novel human C1q/TNF family members, designated as CTRP8 and CTRP9B were described., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A3T6;B9EH31;Q0VGC5;Q5VX65;Q5VX66;Q8IUU4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "B2RNN3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92597-1",
        "uniprot_id": "NDRG1_HUMAN",
        "mass": 42835.0,
        "length": 394,
        "protein_name": "Protein NDRG1",
        "gene_name": "NDRG1",
        "organism": "Human",
        "refseq_name": "protein NDRG1 isoform 1",
        "refseq_ac": "NP_001128714",
        "gene_names_uniprotkb": "NDRG1; CAP43; DRG1; RTP",
        "gene_names_refseq": "CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL; NDR1; NDRG1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5",
        "protein_names_uniprotkb": "Protein NDRG1; DRG-1; Differentiation-related gene 1 protein; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; RTP; Reducing agents and tunicamycin-responsive protein; Rit42",
        "protein_names_refseq": "N-myc downstream-regulated gene 1 protein; differentiation-related gene 1 protein; nickel-specific induction protein Cap43; protein NDRG1 isoform 1; protein NDRG1; protein regulated by oxygen-1; reducing agents and tunicamycin-responsive protein",
        "tax_id": 9606,
        "disease": "Charcot-Marie-Tooth disease type 4D (Disease Ontology:DOID:0110186)",
        "pathway": " (hsa:10397);  (R-HSA-6803205)",
        "pathway_count": 2,
        "publication_count": 133,
        "publication_id_list": "10.1038/emboj.2013.79;10395947;10733530;10831399;10860807;11054413;11237011;11675392;11684014;11714700;11919562;12432451;12872253;1321151;14614825;14729977;15247272;15302935;15377670;15461589;15577913;15797384;15837622;15922294;15958553;16140933;16249378;16964243;17074750;17081983;17220478;17316623;17322306;17442733;17487921;17786215;18452278;18491316;18532927;18669648;18767875;18787837;19040420;19349281;19413330;19549844;19651622;19664994;19690332;20068231;20166139;20416281;21708134;23059823;23182941;23186163;23287991;23301498;23581296;23584533;23634903;23671130;24260043;24275569;24386364;25576301;25645385;26768311;26853435;26992070;27846572;27862975;27894074;28775290;29242379;29303911;29493099;29557506;29679718;29898756;30379171;30410026;30429286;30779550;30833945;30978004;31154438;31189711;31222486;31461270;31844290;31848261;32157095;32161166;32350084;32387766;32488085;32502341;32870666;32897882;32938616;32983136;33043033;33123756;33392160;33398037;33592498;33717175;33968037;33981976;34019948;34405274;34433824;34509645;34561969;35051231;35318648;35580925;36010968;36215666;36241641;36284347;37938771;38271137;38697817;38815861;39201732;40596516;7991565;8939898;9251681;9605764;9766676",
        "class_list": "",
        "function": "Identification and Characterization of Novel Founder Mutations in NDRG1: Refining the Genetic Landscape of Charcot-Marie-Tooth Disease Type 4D in Bulgaria. Publication Status: Online-Only, [RefSeq, PubMed]; Long noncoding RNA MEG3 regulates cell proliferation and apoptosis by disrupting microRNA-9-5p-mediated inhibition of NDRG1 in prostate cancer., [RefSeq, PubMed]; Multi-modal mechanisms of the metastasis suppressor, NDRG1: Inhibition of WNT/beta-catenin signaling by stabilization of protein kinase Calpha., [RefSeq, PubMed]; NDRG1 up-regulation during colon epithelial cell differentiation. First publication on tissue and subcellular expression of NDRG1., [RefSeq, PubMed]; Prostate cancer invasion is promoted by the miR-96-5p-induced NDRG1 deficiency through NF-kappaB regulation., [RefSeq, PubMed]; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]., [RefSeq]; Two disease causing mutations in NDRG1 in Charcot-Marie-Tooth Disease patients. GeneRIF: Observational study of genotype prevalence. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 32,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "diagnostic",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KR80;B7Z446;O15207;Q6IBG2;Q9NYR6;Q9UK29",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008017 microtubule binding;GO:0045296 cadherin binding;GO:0031267 small GTPase binding;GO:0016151 nickel cation binding;GO:0043015 gamma-tubulin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule",
        "go_biological_process": "GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0071456 cellular response to hypoxia;GO:0032287 peripheral nervous system myelin maintenance;GO:0030330 DNA damage response, signal transduction by p53 class mediator",
        "synthesized_glycan_count": 0,
        "hit_score": 13.9,
        "record_id": "Q92597-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96FW1-1",
        "uniprot_id": "OTUB1_HUMAN",
        "mass": 31284.0,
        "length": 271,
        "protein_name": "Ubiquitin thioesterase OTUB1",
        "gene_name": "OTUB1",
        "organism": "Human",
        "refseq_name": "ubiquitin thioesterase OTUB1",
        "refseq_ac": "NP_060140",
        "gene_names_uniprotkb": "OTUB1; HSPC263; OTB1; OTU1",
        "gene_names_refseq": "HSPC263; OTB1; OTU1; OTUB1",
        "protein_names_uniprotkb": "Ubiquitin thioesterase OTUB1; 3.4.19.12; Deubiquitinating enzyme OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; Otubain-1; Ubiquitin-specific-processing protease OTUB1; hOTU1",
        "protein_names_refseq": "OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU-domain Ubal-binding 1; deubiquitinating enzyme OTUB1; otubain-1; ubiquitin thioesterase OTUB1; ubiquitin-specific protease otubain 1; ubiquitin-specific-processing protease OTUB1",
        "tax_id": 9606,
        "disease": "lupus nephritis (Disease Ontology:DOID:0080162); IgA glomerulonephritis (Disease Ontology:DOID:2986)",
        "pathway": " (hsa:55611);  (R-HSA-5689880);  (R-HSA-5689896)",
        "pathway_count": 3,
        "publication_count": 152,
        "publication_id_list": "10385526;10444327;10982817;11237011;11463333;11566882;11923872;12401499;12704427;12917689;12917691;14661020;15053880;15258597;15334086;15916963;16214042;16901786;16964248;17290220;17443180;17873522;17980597;17981138;18172164;18467330;18491316;18632802;18636086;18669648;18954305;18991276;19015242;19135894;19188362;19211026;19363159;19383985;19398555;19424180;19464428;19818707;19838211;19874889;19910467;19996094;20096447;20228808;20368735;20501646;20553488;20725033;21239494;21362556;21571647;21596315;21659512;21849505;21962518;22029577;22085928;22124327;22128162;22216260;22325355;22367539;22645359;23159851;23301498;23395819;23481700;23486064;23824326;23825189;23827681;24056413;24260525;24366607;24493797;24610782;24896179;25197364;25305019;25576301;25578727;25645385;25872870;25904330;26154972;26280536;26992070;27846572;27862975;27920218;28218747;28228285;28510447;28514659;28832583;28904123;29242379;29314611;29382726;29437277;29493099;29557506;29632711;29786170;29789417;30315122;30410026;30429286;30779550;30833945;31154438;31222486;31530632;31844290;32157095;32350084;32387766;32502341;32897882;32938616;32983136;33123756;33214551;33298915;33592498;33633747;33717175;33912179;33968037;34019948;34087483;34171305;34932366;35051231;35138101;35318648;35580925;35927303;36215666;36241641;38266782;38315284;38462165;38644399;38665916;38814988;40914422;7578059",
        "class_list": "",
        "function": "Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation (PubMed:12401499, PubMed:12704427, PubMed:14661020, PubMed:23827681). Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen (PubMed:14661020). Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy (PubMed:14661020). Isoform 1 destabilizes RNF128, leading to prevent anergy (PubMed:14661020). In contrast, isoform 2 stabilizes RNF128 and promotes anergy (PubMed:14661020). Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128 (PubMed:14661020). Deubiquitinates estrogen receptor alpha (ESR1) (PubMed:19383985). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains (PubMed:18954305, PubMed:19211026, PubMed:23827681). Not able to cleave di-ubiquitin (PubMed:18954305, PubMed:23827681). Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (PubMed:18954305, PubMed:23827681)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; OTUB1 Targets CHK1 for Deubiquitination and Stabilization to Facilitate Lung Cancer Progression and Radioresistance., [RefSeq, PubMed]; OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via its non-canonical ubiquitination., [RefSeq, PubMed]; OTUB1 contributes to the stability and function of Influenza A virus NS2. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites (PubMed:20725033, PubMed:22325355). Inhibits RNF168 independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N/UBC13, the E2 partner of RNF168, thereby limiting spreading of 'Lys-63'-linked histone H2A and H2AX marks (PubMed:20725033, PubMed:22325355). Inhibition occurs by binding to free ubiquitin: free ubiquitin acts as an allosteric regulator that increases affinity for UBE2N/UBC13 and disrupts interaction with UBE2V1 (PubMed:20725033, PubMed:22325355). The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved 'Lys48'-linked di-ubiquitin chain (PubMed:20725033, PubMed:22325355). Acts as a regulator of mTORC1 and mTORC2 complexes (PubMed:29382726, PubMed:35927303). When phosphorylated at Tyr-26, acts as an activator of the mTORC1 complex by mediating deubiquitination of RPTOR via a non-catalytic process: acts by binding and inhibiting the activity of the ubiquitin-conjugating enzyme E2 (UBE2D1/UBCH5A, UBE2W/UBC16 and UBE2N/UBC13), thereby preventing ubiquitination of RPTOR (PubMed:35927303). Can also act as an inhibitor of the mTORC1 and mTORC2 complexes in response to amino acids by mediating non-catalytic deubiquitination of DEPTOR (PubMed:29382726)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRbeta., [RefSeq, PubMed]; The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]., [RefSeq]; YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 21,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q32Q78;Q96II3;Q9NXQ4;Q9P0B8",
        "ec_number_list": "3.4.19.12;2.3.2.24;2.3.2.23;3.6.5.2;2.3.2.27",
        "go_molecular_function": "GO:0019784 deNEDDylase activity;GO:0031625 ubiquitin protein ligase binding;GO:0043130 ubiquitin binding;GO:0055105 ubiquitin-protein transferase inhibitor activity;GO:0004843 cysteine-type deubiquitinase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0005737 cytoplasm",
        "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:2000780 negative regulation of double-strand break repair;GO:0006281 DNA repair;GO:0006508 proteolysis;GO:0016579 protein deubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 15.5,
        "record_id": "Q96FW1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H8V3-1",
        "uniprot_id": "ECT2_HUMAN",
        "mass": 103505.0,
        "length": 914,
        "protein_name": "Protein ECT2",
        "gene_name": "ECT2",
        "organism": "Human",
        "refseq_name": "protein ECT2 isoform a",
        "refseq_ac": "NP_001245244",
        "gene_names_uniprotkb": "ECT2",
        "gene_names_refseq": "ARHGEF31; ECT2",
        "protein_names_uniprotkb": "Protein ECT2; Epithelial cell-transforming sequence 2 oncogene",
        "protein_names_refseq": "epithelial cell-transforming sequence 2 oncogene; protein ECT2 isoform a; protein ECT2",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)",
        "pathway": " (hsa:1894);  (R-HSA-193648);  (R-HSA-416482);  (R-HSA-8980692);  (R-HSA-9013026);  (R-HSA-9013148);  (R-HSA-9013149)",
        "pathway_count": 7,
        "publication_count": 459,
        "publication_id_list": "10.1101/2023.09.13.557529;10037681;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10619026;10699171;10699464;10724160;10873388;10873802;10958683;11007481;11058585;11085924;11149925;11207612;11237011;11283606;11294240;11306516;11313914;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11680691;11689693;11696321;11704860;11707441;11742120;11756498;11756552;11773441;11803464;11804587;11804589;11804590;11884391;11912491;11948177;11961559;12071859;12093360;12096337;12097334;12101119;12123608;12172552;12195014;12221077;12221096;12351724;12432077;12433842;12464619;12473120;12515866;12531887;12546821;12547822;12650940;12665586;12750860;12773384;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;14587037;14645260;1464587;14673001;14675773;14718541;15023524;15033976;15064355;15107133;15133129;15147912;15157669;15254234;15260990;15302923;15304341;15339924;15342493;15470142;15485661;15507211;15545273;15579468;15601624;15611138;15642749;15699075;15728722;15749160;15850391;15858067;15866170;15897194;15944396;15951850;16002401;16103226;16112081;16116428;16129829;16170345;16184169;16212495;16217026;16236794;16243036;16247472;16394104;16467373;16473593;16492808;16495035;16507994;16519628;16630611;16636067;16702231;16714282;16762923;16776779;16777452;16777849;16862148;16896804;16914516;16917499;16923326;16959974;16968698;17064668;17077126;17115030;17145773;17196961;17198702;17214551;17244649;17562871;17583407;17599059;17702745;17765681;17804252;17932950;17942708;17976533;18006505;18045877;18056264;18158243;18218625;18220336;18249095;18347018;18363964;18374420;18396277;18426980;18511905;18577758;18653540;18669648;18786931;18802007;18829452;18835169;18838382;18929667;19129481;19212140;19269969;19468300;19468302;19494238;19605563;19617897;19635168;19673492;19713215;19934221;20030946;20068231;20101212;20400958;20460433;20591975;20628200;20660154;20679435;20810653;21148482;21189248;21351730;21373644;21406692;21454492;21542010;21565175;21613211;21685891;21699497;21730051;21865595;21936715;21989057;22004470;22096251;22298643;22305756;22407364;22461490;22475431;22571869;22608513;22661716;22673745;22734669;22911862;22970203;22992742;23186163;23200924;23209303;23255595;23288169;23406282;23434736;23481700;23572525;23707487;23718289;23870313;23940355;24086303;24128008;24259668;24335996;24352656;24366607;24397554;24584464;24714562;24715725;24859002;24933155;24960694;24996924;25024229;25068414;25211221;25414122;25418920;25428919;25576301;25673874;25704760;25721503;25795300;25862245;25892735;25963737;26129894;26154972;26299518;26371245;26375851;26529257;26598554;26728094;26811146;26887924;26929215;26992070;27072905;27096001;27117132;27145964;27216196;27397612;27481945;27555588;27566826;27600516;27713499;27798618;27806292;27846572;27862975;27920218;27986909;28028151;28063628;28112683;28114311;28196833;28218747;28228285;28446606;28514659;28584191;28649982;28825699;28832583;28834231;28860633;28904123;29089502;29146911;29242379;29331515;29358323;29382922;29393594;29437277;29493099;29557506;29632046;29769354;29789417;30007591;30061681;30278072;30315122;30379171;30410026;30484775;30620550;30853411;31105010;31217245;31492838;31844290;31871319;31888991;32157095;32203420;32265295;32357974;32387766;32488085;32897882;32938616;32983136;33091337;33141586;33298915;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34093574;34171305;34211107;34433824;34509645;34932366;35051231;35132862;35318648;35561310;35580925;36010968;36056253;36215666;36241641;36284347;36355210;36416720;36503048;36567178;36581221;37938771;39302247;39531497;39534244;7479768;7512369;7559638;7673236;7721814;7753201;7835339;7937899;8021274;8107774;8537347;8543060;8571126;8617235;8643598;8645157;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8807639;8810315;8816443;8939998;8990121;8994827;9013646;9099726;9111050;9113980;9268338;9305890;9308960;9405671;9418861;9438849;9490638;9497316;9520479;9535835;9548756;9582072;9659915;9670022;9792683;9796816;9822598;9822605;9829970;9843499;9846874;9988689",
        "class_list": "",
        "function": "CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway., [RefSeq, PubMed]; Cytokinetic diversity in mammalian cells is revealed by the characterization of endogenous anillin, Ect2 and RhoA., [RefSeq, PubMed]; ECT2 promotes malignant phenotypes through the activation of the AKT/mTOR pathway and cisplatin resistance in cervical cancer., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Long noncoding RNA MAPKAPK5-AS1 promotes metastasis through regulation miR-376b-5p/ECT2 axis in hepatocellular carcinoma., [RefSeq, PubMed]; MiRNA-223-3p regulates ECT2 to promote proliferation, invasion, and metastasis of gastric cancer through the Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]; The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 5,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 23,
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        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0MT80;Q2M269;Q6U836;Q9NSV8;Q9NVW9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042803 protein homodimerization activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:1903438 positive regulation of mitotic cytokinetic process;GO:0007399 nervous system development;GO:0015031 protein transport;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 46.8,
        "record_id": "Q9H8V3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P63098-1",
        "uniprot_id": "CANB1_HUMAN",
        "mass": 19300.0,
        "length": 170,
        "protein_name": "Calcineurin subunit B type 1",
        "gene_name": "PPP3R1",
        "organism": "Human",
        "refseq_name": "calcineurin subunit B type 1",
        "refseq_ac": "NP_000936",
        "gene_names_uniprotkb": "PPP3R1; CNA2; CNB",
        "gene_names_refseq": "CALNB1; CNB1; CNB; PPP3R1",
        "protein_names_uniprotkb": "Calcineurin subunit B type 1; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1",
        "protein_names_refseq": "calcineurin B, type I (19kDa); calcineurin subunit B type 1; protein phosphatase 2B regulatory subunit 1; protein phosphatase 2B regulatory subunit B alpha",
        "tax_id": 9606,
        "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); dilated cardiomyopathy (Disease Ontology:DOID:12930); schizophrenia (Disease Ontology:DOID:5419)",
        "pathway": " (hsa:5534);  (R-HSA-111447);  (R-HSA-180024);  (R-HSA-2025928);  (R-HSA-2871809);  (R-HSA-4086398);  (R-HSA-5607763)",
        "pathway_count": 7,
        "publication_count": 137,
        "publication_id_list": "10195903;10380924;10391246;10391247;10395542;10488343;10588714;10604473;10777564;10858654;10860980;10949026;11015615;11015619;11030334;11231878;11237011;11395409;11563835;11697890;12015605;12065642;12086864;12218175;12357034;12471263;12482967;12556497;12573241;12657644;12729560;12809556;12975316;14704854;14977528;15494017;15545263;15611108;15660102;16880514;16920709;1715244;17426020;17498738;17502104;17535922;17684012;18296442;18456304;18488142;18669648;19177143;19536106;19851316;20068231;21118996;21903638;22343722;22941947;23151663;23256519;23416699;23468591;23632248;23904219;2445721;24715725;25255805;25576301;2558868;26154972;26590425;26794871;27600516;27846572;27920218;27974827;2841328;28467828;28832583;28904123;29508533;29557506;29632711;29786170;30294901;30833945;31154438;31375679;31530632;31844290;31848261;31998317;32157095;32350084;32357974;32488085;32502341;32938616;32983136;33592498;33691108;33717175;33968037;34171305;34357683;34561969;34932366;35051231;35154160;35580925;36010968;36241641;36284347;36901851;37938771;6087160;6296685;6330098;6501302;7518558;7657645;8524402;8576111;8629002;8630736;8631904;8663227;8684469;8799126;9073455;9099992;9106655;9312192;9371714;9389482;9727000",
        "class_list": "",
        "function": "PPP3R1 Promotes MSCs Senescence by Inducing Plasma Membrane Depolarization and Increasing Ca[2+] Influx. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RC10;B5MDU4;P06705;P15117;Q08044;Q53SL0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019904 protein domain specific binding;GO:0005509 calcium ion binding;GO:0019902 phosphatase binding;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0098794 postsynapse",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0070886 positive regulation of calcineurin-NFAT signaling cascade;GO:1905665 positive regulation of calcium ion import across plasma membrane;GO:0033173 calcineurin-NFAT signaling cascade;GO:0099170 postsynaptic modulation of chemical synaptic transmission",
        "synthesized_glycan_count": 0,
        "hit_score": 13.8,
        "record_id": "P63098-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92905-1",
        "uniprot_id": "CSN5_HUMAN",
        "mass": 37579.0,
        "length": 334,
        "protein_name": "COP9 signalosome complex subunit 5",
        "gene_name": "COPS5",
        "organism": "Human",
        "refseq_name": "COP9 signalosome complex subunit 5",
        "refseq_ac": "NP_006828",
        "gene_names_uniprotkb": "COPS5; CSN5; JAB1",
        "gene_names_refseq": "COPS5; CSN5; JAB1; MOV-34; SGN5",
        "protein_names_uniprotkb": "COP9 signalosome complex subunit 5; 3.4.-.-; Jun activation domain-binding protein 1; SGN5; Signalosome subunit 5",
        "protein_names_refseq": "38 kDa Mov34 homolog; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; jun activation domain-binding protein 1; signalosome subunit 5; testis secretory sperm-binding protein Li 231m",
        "tax_id": 9606,
        "disease": "autoimmune pancreatitis (Disease Ontology:DOID:0040091); chronic pancreatitis (Disease Ontology:DOID:0051065); colorectal carcinoma (Disease Ontology:DOID:0080199); autosomal recessive osteopetrosis 3 (Disease Ontology:DOID:0110941); primary biliary cholangitis (Disease Ontology:DOID:12236); Sjogren's syndrome (Disease Ontology:DOID:12894); osteopetrosis (Disease Ontology:DOID:13533); viral hepatitis (Disease Ontology:DOID:1884); Lynch syndrome (Disease Ontology:DOID:3883); bladder urothelial carcinoma (Disease Ontology:DOID:4006); alcoholic pancreatitis (Disease Ontology:DOID:4988); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074)",
        "pathway": " (hsa:10987);  (R-HSA-5696394);  (R-HSA-6781823);  (R-HSA-8856825);  (R-HSA-8951664);  (R-HSA-9929356)",
        "pathway_count": 6,
        "publication_count": 324,
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        "class_list": "",
        "function": "Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; METTL3 upregulates COPS5 expression in osteosarcoma in an m(6)A-related manner to promote osteosarcoma progression., [RefSeq, PubMed]; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Regulatory mechanisms and therapeutic potential of JAB1 in neurological development and disorders. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 14,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15386;Q6AW95;Q86WQ4;Q9BQ17",
        "ec_number_list": "3.6.4.-;5.6.2.3;5.6.2.4;3.1.13.-;2.7.7.48;2.7.7.6;2.7.11.22;2.7.11.23;2.7.11.24;1.14.11.-;2.3.2.27;2.3.2.32;3.4.-.-;3.6.4.12",
        "go_molecular_function": "GO:0019784 deNEDDylase activity;GO:0035718 macrophage migration inhibitory factor binding;GO:0003713 transcription coactivator activity;GO:0008237 metallopeptidase activity;GO:0019899 enzyme binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:1903894 regulation of IRE1-mediated unfolded protein response;GO:1990182 exosomal secretion;GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0043687 post-translational protein modification",
        "synthesized_glycan_count": 0,
        "hit_score": 32.7,
        "record_id": "Q92905-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14134-1",
        "uniprot_id": "TRI29_HUMAN",
        "mass": 65835.0,
        "length": 588,
        "protein_name": "Tripartite motif-containing protein 29",
        "gene_name": "TRIM29",
        "organism": "Human",
        "refseq_name": "tripartite motif-containing protein 29 isoform 1",
        "refseq_ac": "NP_036233",
        "gene_names_uniprotkb": "TRIM29; ATDC",
        "gene_names_refseq": "ATDC; TRIM29",
        "protein_names_uniprotkb": "Tripartite motif-containing protein 29; Ataxia telangiectasia group D-associated protein",
        "protein_names_refseq": "ataxia-telangiectasia group D-associated protein; tripartite motif protein TRIM29; tripartite motif-containing protein 29 isoform 1; tripartite motif-containing protein 29",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23650);  (R-HSA-877300)",
        "pathway_count": 2,
        "publication_count": 82,
        "publication_id_list": "10067896;10986460;11237011;11331580;11972023;12040185;12438563;12446674;12915721;1396683;14586410;14722222;1508672;15143187;15322115;15388922;15530433;16237089;16467876;16959974;16964243;17016520;17125875;17924679;18362138;18591661;18669648;18691976;19007248;20049711;20068231;20130243;20304997;20363976;23061660;23186163;24417533;25576301;26992070;27695001;28510447;29038422;29557506;30059200;30397120;30484775;31154438;32157095;32938616;33239784;33465208;34171305;34185709;35051231;35318648;36215666;36284347;38029830;38345749;38393440;38518727;38837682;7510216;7514165;7530745;7615558;7617032;7644499;7657660;7673114;7690989;7796299;8156998;8176225;8188213;8483949;8530158;8550631;8631301;8647648;9111318;9143706",
        "class_list": "",
        "function": "LncRNA PVT1 facilitates the growth and metastasis of colorectal cancer by sponging with miR-3619-5p to regulate TRIM29 expression., [RefSeq, PubMed]; O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency., [RefSeq, PubMed]; Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation., [UniProtKB, PubMed, PubMed]; TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770-5p axis in PDAC., [RefSeq, PubMed]; TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM29 promotes antitumor immunity through enhancing IGF2BP1 ubiquitination and subsequent PD-L1 downregulation in gastric cancer., [RefSeq, PubMed]; The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96AA9;Q9BZY7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0098641 cadherin binding involved in cell-cell adhesion;GO:0002039 p53 binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005912 adherens junction;GO:0005764 lysosome",
        "go_biological_process": "GO:0045087 innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "Q14134-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N9H9-1",
        "uniprot_id": "CIROZ_HUMAN",
        "mass": 89019.0,
        "length": 823,
        "protein_name": "Ciliated left-right organizer ZP-N domains-containing protein",
        "gene_name": "CIROZ",
        "organism": "Human",
        "refseq_name": "ciliated left-right organizer ZP-N domains-containing protein isoform 1 precursor",
        "refseq_ac": "NP_001164225",
        "gene_names_uniprotkb": "CIROZ; C1orf127",
        "gene_names_refseq": "C1orf127; CIROZ; HTX14",
        "protein_names_uniprotkb": "Ciliated left-right organizer ZP-N domains-containing protein; Ciliated left-right organizer protein containing ZP-N domains",
        "protein_names_refseq": "ciliated left-right organizer ZP-N domains-containing protein isoform 1 precursor; ciliated left-right organizer ZP-N domains-containing protein; uncharacterized protein C1orf127",
        "tax_id": 9606,
        "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); visceral heterotaxy 14 (Disease Ontology:DOID:0061123); primary ciliary dyskinesia (Disease Ontology:DOID:9562); dextrocardia (Disease Ontology:DOID:9565)",
        "pathway": " (hsa:148345)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;39753129",
        "class_list": "",
        "function": "Plays a role in left-right patterning process., [UniProtKB, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVG8;A6NKM7;B7ZLG7;G8JLG8;Q5VXJ2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0061966 establishment of left/right asymmetry",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q8N9H9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H251-1",
        "uniprot_id": "CAD23_HUMAN",
        "mass": 369494.0,
        "length": 3354,
        "protein_name": "Cadherin-23",
        "gene_name": "CDH23",
        "organism": "Human",
        "refseq_name": "cadherin-23 isoform 3 precursor",
        "refseq_ac": "NP_001165401",
        "gene_names_uniprotkb": "CDH23; KIAA1774; KIAA1812; PRO4340",
        "gene_names_refseq": "CDH23; CDHR23; PITA5; USH1D",
        "protein_names_uniprotkb": "Cadherin-23; Otocadherin",
        "protein_names_refseq": "cadherin-23 isoform 3 precursor; cadherin-like 23; cadherin-related family member 23; otocadherin",
        "tax_id": 9606,
        "disease": "Usher syndrome (Disease Ontology:DOID:0050439); autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565); Usher syndrome type 1B (Disease Ontology:DOID:0070655); autosomal recessive nonsyndromic deafness 12 (Disease Ontology:DOID:0110467); Usher syndrome type 1D (Disease Ontology:DOID:0110831); pituitary adenoma 5 (Disease Ontology:DOID:0112008)",
        "pathway": " (hsa:64072);  (R-HSA-9662360);  (R-HSA-9662361)",
        "pathway_count": 3,
        "publication_count": 52,
        "publication_id_list": "10.1101/2023.09.13.557529;10025409;10821263;11090341;11138009;11163272;11237011;11597768;12075507;12522556;12975309;15537665;15660226;15829536;15882574;16679490;17234811;17850630;18429043;19297620;20498078;21436032;22899989;23481700;24715725;24767429;24916380;25892735;27920218;28228285;28413019;28887846;28904123;29557506;29671580;30315122;30429286;31154438;31844290;31848261;32276436;32387766;32488085;32502341;32938616;32983136;33592498;34087483;35051231;36010968;38253038;39017633",
        "class_list": "",
        "function": "CDH23-Associated Usher Syndrome: Clinical Features, Retinal Imaging, and Natural History., [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing., [UniProtKB, PubMed, PubMed]; Describes cloning of human and mouse isoforms B1, B2, C1 and C2., [RefSeq, PubMed]; Determined the structure of the extracellular cadherin (EC)1-EC2 domains of cadherin 23, which binds to protocadherin 15 to form tip links of mechanosensory hair cells., [RefSeq, PubMed]; This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013]., [RefSeq]",
        "predicted_glycosites": 39,
        "predicted_n_glycosites": 39,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 224,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 6,
        "glyco_site_count": 42,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C4IXS9;F6U049;Q5QGS1;Q5QGS2;Q5QGS5;Q5QGS6;Q5XKN2;Q6UWW1;Q96JL3;Q9H4K9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding",
        "go_cellular_component": "GO:0005813 centrosome;GO:0016020 membrane;GO:0001917 photoreceptor inner segment;GO:0016342 catenin complex;GO:0060091 kinocilium",
        "go_biological_process": "GO:0016477 cell migration;GO:0031175 neuron projection development;GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0007601 visual perception",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "Q9H251-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13617-1",
        "uniprot_id": "CUL2_HUMAN",
        "mass": 86983.0,
        "length": 745,
        "protein_name": "Cullin-2",
        "gene_name": "CUL2",
        "organism": "Human",
        "refseq_name": "cullin-2 isoform c",
        "refseq_ac": "NP_001185706",
        "gene_names_uniprotkb": "CUL2",
        "gene_names_refseq": "CUL2",
        "protein_names_uniprotkb": "Cullin-2; CUL-2",
        "protein_names_refseq": "CUL-2; cullin-2 isoform c; testis secretory sperm-binding protein Li 238E",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8453);  (R-HSA-1234176);  (R-HSA-8951664);  (R-HSA-9010553);  (R-HSA-983168);  (R-HSA-9954709)",
        "pathway_count": 6,
        "publication_count": 245,
        "publication_id_list": "10.1101/2023.09.13.557529;10092517;10230407;10535940;10597293;10811609;10823831;10878807;10944113;10973499;11024059;11062501;11069780;11237011;11259415;11292861;11292862;11350924;11358837;11384984;11454738;11504942;11585840;11598268;11733065;11961546;12101228;12149480;12186903;12351678;12504025;12504026;12526791;12538644;12609982;12615973;12646216;12682069;12759363;12788921;12816948;12821933;12912907;14690597;14734113;14757770;15224091;15224092;15247232;15282312;15361859;15367669;15474027;15537541;15571818;15572695;15574592;15601820;15601839;15652483;15652751;15688063;15694336;15799966;15987702;16171779;16401342;16547496;16595681;16647857;16707496;16738327;16790436;16849449;16943200;16954532;17081101;17132228;17182618;17183367;17220875;17251292;17304241;17332328;17434750;17497243;17785452;18093314;18184961;18206966;18337469;18662542;18669648;18775313;18776931;18805092;18826954;18851830;18926707;19028597;19208626;19250909;19321346;19352404;19452197;19489725;19608861;19617556;19706539;19748355;19851334;19874575;19940261;21335549;21447816;21463634;21778237;21863050;21940857;22286099;22306028;22424782;22466964;22537386;2261476;22898188;22959436;23102700;23186163;23201271;23217742;23301498;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23685075;23746841;23912815;23986495;24076655;24192928;24366543;24636985;24793695;24793696;25132172;25242263;25314029;25349211;25355947;25531226;25578875;25645385;25880248;26138980;26154972;26344709;26460955;26632597;26906416;26992070;27030794;27222660;27565346;27600516;27846572;28115426;28228285;28510447;28514659;28832583;28904123;29153394;29242379;29493099;29557506;29632312;29769354;29775578;29779948;29786170;30244831;30410026;30524438;30610225;31011209;31844290;32005965;32157095;32284348;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33406423;33444648;33537174;33592498;33633747;33691108;33717175;33909987;33936100;33968037;33981976;34019948;34087483;34171305;34357683;34405274;34509645;34700328;34725712;35051231;35154160;35561310;35580925;36010968;36215666;36241641;37397007;37676773;37844242;37938771;38326650;38787355;38978293;8681378;9122164;9380723;9668046;9790970;9887101;9891082",
        "class_list": "",
        "function": "Comprehensive prognostic and immunological analysis of Cullin2 in pan-cancer and its identification in hepatocellular carcinoma., [RefSeq, PubMed]; Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:11384984, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:37844242, PubMed:38326650). CUL2 serves as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the E2 ubiquitin-conjugating enzyme (PubMed:10973499, PubMed:11384984, PubMed:12609982, PubMed:24076655, PubMed:9122164, PubMed:37844242, PubMed:38326650). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (PubMed:12609982, PubMed:24076655, PubMed:27565346, PubMed:38326650). The functional specificity of the ECS complex depends on the substrate recognition component (PubMed:10973499, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:9122164, PubMed:38326650). ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (PubMed:10973499, PubMed:9122164). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:37844242). ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; TRAF2 associates with cullin neddylation complex assembly., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KT95;B7Z6K8;D3DRY6;G3V1S2;O00200;Q5T2B6;Q9UNF9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0160072 ubiquitin ligase complex scaffold activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:2000104 negative regulation of DNA-templated DNA replication;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 25.2,
        "record_id": "Q13617-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N5Z5-1",
        "uniprot_id": "KCD17_HUMAN",
        "mass": 34888.0,
        "length": 314,
        "protein_name": "BTB/POZ domain-containing protein KCTD17",
        "gene_name": "KCTD17",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing protein KCTD17 isoform 4",
        "refseq_ac": "NP_001269615",
        "gene_names_uniprotkb": "KCTD17",
        "gene_names_refseq": "KCTD17",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD17",
        "protein_names_refseq": "BTB/POZ domain-containing protein KCTD17 isoform 4; BTB/POZ domain-containing protein KCTD17",
        "tax_id": 9606,
        "disease": "myoclonic dystonia (Disease Ontology:DOID:0090033); myoclonic dystonia 26 (Disease Ontology:DOID:0090036)",
        "pathway": " (hsa:79734)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;18477386;25270598;25983243;28832583;28963344;29242379;31154438;31848261;32161166;34105348",
        "class_list": "",
        "function": "A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia., [RefSeq, PubMed]; Substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediates the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation. Thereby, positively regulates ciliogenesis, playing a crucial role in the initial steps of axoneme extension (PubMed:25270598). May also play a role in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243)., [UniProtKB, PubMed, PubMed]; This gene encodes a protein that belongs to a conserved family of potassium channel tetramerization domain (KCTD)-containing proteins. The encoded protein functions in ciliogenesis by acting as a substrate adaptor for the cullin3-based ubiquitin-conjugating enzyme E3 ligase, and targets trichoplein, a keratin-binding protein, for degradation via polyubiquitinylation. A mutation in this gene is associated with autosomal dominant myoclonic dystonia 26. [provided by RefSeq, Nov 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0QYA9;B0QYB0;O95517",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0097602 cullin family protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0031463 Cul3-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030030 cell projection organization;GO:0032469 endoplasmic reticulum calcium ion homeostasis;GO:0045724 positive regulation of cilium assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q8N5Z5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H0E9-1",
        "uniprot_id": "BRD8_HUMAN",
        "mass": 135336.0,
        "length": 1235,
        "protein_name": "Bromodomain-containing protein 8",
        "gene_name": "BRD8",
        "organism": "Human",
        "refseq_name": "bromodomain-containing protein 8 isoform 4",
        "refseq_ac": "NP_001157798",
        "gene_names_uniprotkb": "BRD8; SMAP2; SMAP",
        "gene_names_refseq": "BRD8; SMAP2; SMAP; p120",
        "protein_names_uniprotkb": "Bromodomain-containing protein 8; Skeletal muscle abundant protein 2; Skeletal muscle abundant protein; Thyroid hormone receptor coactivating protein of 120 kDa; TrCP120; p120",
        "protein_names_refseq": "bromodomain-containing protein 8 isoform 4; bromodomain-containing protein 8; skeletal muscle abundant protein 2; thyroid hormone receptor coactivating protein of 120 kDa; trCP120",
        "tax_id": 9606,
        "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)",
        "pathway": " (hsa:10902);  (R-HSA-3214847)",
        "pathway_count": 2,
        "publication_count": 115,
        "publication_id_list": "10517671;10786633;10821277;11230166;11237011;12963728;14966270;15196461;15313887;16387653;17081983;18381289;18452278;18623064;18669648;19187765;19367720;19413330;19608861;19651622;19690332;19691289;20018852;20068231;23186163;23301498;23481700;24275569;24463511;24714562;24715725;25114211;25218447;25576301;25593309;25645385;25755297;25772364;25892735;26154972;26375851;26960196;26992070;27920218;28228285;28352266;28514659;28649982;28657654;28832583;28834231;28904123;29242379;29331515;29351928;29393594;29508533;29557506;29769354;29789417;30192525;30379171;30620550;31217245;31492838;31844290;32119511;32157095;32357974;32488085;32502341;32860757;32938616;32938750;32983136;33298915;33392160;33476703;33592498;33691108;33717175;33912179;33968037;33981976;34087483;34171305;34405274;34725712;35051231;35132862;35138101;35254053;35318648;35561310;35580925;36241641;36284347;36544023;36581221;37340703;37541260;37938771;38253038;38665916;38838015;38965933;39531497;39534244;40307207;40596516;8611617;9368056;9427644;9558366;9880483",
        "class_list": "",
        "function": "BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network., [RefSeq, PubMed]; BRD8, which is negatively regulated by miR-876-3p, promotes the proliferation and apoptosis resistance of hepatocellular carcinoma cells via KAT5., [RefSeq, PubMed]; May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome., [UniProtKB, PubMed, PubMed, PubMed]; The Bromodomain Containing 8 (BRD8) transcriptional network in human lung epithelial cells., [RefSeq, PubMed]; The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]., [RefSeq]; Understanding the role of BRD8 in human carcinogenesis. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 12,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 12,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 12,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43178;Q15355;Q58AB0;Q59GN0;Q969M9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046966 nuclear thyroid hormone receptor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007166 cell surface receptor signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 13.0,
        "record_id": "Q9H0E9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P55287-1",
        "uniprot_id": "CAD11_HUMAN",
        "mass": 87965.0,
        "length": 796,
        "protein_name": "Cadherin-11",
        "gene_name": "CDH11",
        "organism": "Human",
        "refseq_name": "cadherin-11 isoform 2 precursor",
        "refseq_ac": "NP_001295321",
        "gene_names_uniprotkb": "CDH11",
        "gene_names_refseq": "CAD11; CDH11; CDHOB; ESWS; OB; OSF-4; TBHS2",
        "protein_names_uniprotkb": "Cadherin-11; OB-cadherin; OSF-4; Osteoblast cadherin",
        "protein_names_refseq": "cadherin 11, type 2, OB-cadherin (osteoblast); cadherin-11 isoform 2 precursor",
        "tax_id": 9606,
        "disease": "Elsahy-Waters syndrome (Disease Ontology:DOID:0080631); Teebi hypertelorism syndrome 2 (Disease Ontology:DOID:0081074); prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:1009);  (R-HSA-418990);  (R-HSA-9759811);  (R-HSA-9762292);  (R-HSA-9833576);  (R-HSA-9958810);  (R-HSA-9958825)",
        "pathway_count": 7,
        "publication_count": 71,
        "publication_id_list": "10225955;10320525;10861224;11237011;12050160;14517306;15026324;16467305;17686471;17967169;18555777;18578522;18653540;19354288;19415658;2059658;2183031;22036506;22117219;22323579;23090970;23497265;2405250;24190977;25372031;25466890;25502872;25546151;27397612;28278510;28317937;28740178;28988429;29110486;29271567;29356040;29417701;29557506;30429286;30779550;31154438;31848261;32234673;32387766;33271553;33592498;33811546;33968037;34215617;35580925;36284347;37074911;37171723;37558205;37737289;37938771;38665916;38871245;38875295;7510216;7512451;7806582;7982033;8140422;8163513;8234276;8626374;8662591;8662795;9219219;9845526",
        "class_list": "",
        "function": "Cadherin-11 contributes to the heterogenous and dynamic Wnt-Wnt-beta-catenin pathway activation in Ewing sarcoma. Publication Status: Online-Only, [RefSeq, PubMed]; Cadherin-11 increases tumor cell proliferation and metastatic potential via Wnt pathway activation., [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation of cell migration (PubMed:33811546)., [UniProtKB, PubMed]; Computational evidence for multi-layer crosstalk between the cadherin-11 and PDGFR pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Let-7c-3p suppresses lens epithelial-mesenchymal transition by inhibiting cadherin-11 expression in fibrotic cataract., [RefSeq, PubMed]; This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]., [RefSeq]; YTHDF1 promotes the osteolytic bone metastasis of breast cancer via inducing EZH2 and CDH11 translation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 62,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 4,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5D6;A8MZC8;B7WP28;Q15065;Q15066;Q9UQ93;Q9UQ94",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0030336 negative regulation of cell migration;GO:0000902 cell morphogenesis;GO:0001501 skeletal system development",
        "synthesized_glycan_count": 0,
        "hit_score": 8.1,
        "record_id": "P55287-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P12830-1",
        "uniprot_id": "CADH1_HUMAN",
        "mass": 97456.0,
        "length": 882,
        "protein_name": "Cadherin-1",
        "gene_name": "CDH1",
        "organism": "Human",
        "refseq_name": "cadherin-1 isoform 2 precursor",
        "refseq_ac": "NP_001304113",
        "gene_names_uniprotkb": "CDH1; CDHE; UVO",
        "gene_names_refseq": "Arc-1; BCDS1; CD324; CDH1; CDHE; ECAD; LCAM; UVO",
        "protein_names_uniprotkb": "Cadherin-1; CAM 120/80; E-cadherin; Epithelial cadherin; Uvomorulin",
        "protein_names_refseq": "E-cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1, E-cadherin (epithelial); cadherin-1 isoform 2 precursor; calcium-dependent adhesion protein, epithelial; cell-CAM 120/80; epididymis secretory sperm binding protein; epithelial cadherin; uvomorulin",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); blepharocheilodontic syndrome (Disease Ontology:DOID:0080344); blepharocheilodontic syndrome 1 (Disease Ontology:DOID:0080345); hereditary diffuse gastric cancer (Disease Ontology:DOID:0080764); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); invasive lobular carcinoma (Disease Ontology:DOID:3457); pulmonary fibrosis (Disease Ontology:DOID:3770); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); renal cell carcinoma (Disease Ontology:DOID:4450); mucoepidermoid carcinoma (Disease Ontology:DOID:4531); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); cleft lip (Disease Ontology:DOID:9296); diabetes mellitus (Disease Ontology:DOID:9351)",
        "pathway": " (hsa:999);  (R-HSA-1474228);  (R-HSA-198933);  (R-HSA-216083);  (R-HSA-351906);  (R-HSA-418990);  (R-HSA-5626467);  (R-HSA-8876493);  (R-HSA-9764561);  (R-HSA-9764562);  (R-HSA-9766229);  (R-HSA-9768727);  (R-HSA-9823730);  (R-HSA-9856649);  (R-HSA-9926550);  (R-HSA-9927418);  (R-HSA-9927432);  (R-HSA-9938206);  (R-HSA-9958810);  (R-HSA-9958825)",
        "pathway_count": 20,
        "publication_count": 434,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10209034;10225955;10229672;10319582;10366422;10386589;10406800;10438935;10473551;10499918;10543983;10567402;10593924;10597309;10605720;10611221;10640428;10655586;10671552;10673366;10673502;10706100;10713152;10746781;10748026;10809722;10811134;10896919;10982388;10986281;11027551;11076937;11158588;11226248;11237011;11265639;11305955;11375993;11489943;11500511;11513152;11518510;11556966;11562785;11572855;11705864;11713259;11790773;11807247;11840323;11856755;11857637;11858820;11861603;11872628;11891324;11912130;11930005;11948177;11953314;11955593;11955595;11955599;11968083;11976333;11980922;12050160;12110184;12213321;12216071;12483297;12496264;12526809;12585966;12588680;12588804;12604719;12682293;12727852;12807887;12843408;14517306;14595118;14699157;14719373;14970179;14973287;14975237;15001579;15034010;15054114;15118077;15136729;15155468;15187158;15226305;15234972;15235021;15240572;15240885;15304001;15330449;15345499;15383545;15507434;15534202;15541655;15580655;15591058;15607800;15689490;15713743;15778510;15781451;15800062;15851719;15864273;15870707;1588291;15899827;15958533;16002701;16014379;16014749;16034366;16051604;16091383;16126725;16129954;16133547;16239428;16286477;16339513;16380601;16417575;16467305;1649600;16551255;16631740;16731529;16737824;16754661;16754721;16822840;16825321;16893496;16904340;16928187;16933105;1698554;1698775;17045824;17057721;1707285;17204604;17224074;17237375;17244649;17261850;17332331;17337780;17339034;17354228;1748288;17540170;17559062;17608959;17623675;17627624;17660459;17668349;17686471;17715295;17850815;17893710;17967169;17968485;18031695;18037897;18055229;18093941;18209062;18234675;18237546;18343367;18434311;18491227;18555777;18566446;18593354;18624796;18644867;18653540;18658137;18710925;18775695;19010778;19079338;19149696;19354288;19359216;19403558;19502598;19524539;19564924;19571574;19590037;19592130;19604491;19608861;19657146;19714641;19737400;19940119;20033473;20066110;2010551;20116244;20142769;20371349;20418909;20432435;20460180;20705068;20730098;20859650;21030783;21241660;21245162;21283129;21297635;21299499;21441952;21486943;21630377;21670566;21730051;21784848;21800138;2183031;21841309;21855631;21864727;21877119;21965087;22036506;22117219;22159414;22252131;22294297;22323579;22375065;22396535;22539938;22647378;22770219;22884367;22944912;23035980;23159739;23190890;23207919;23374253;2349235;23524144;23532847;23584533;23695528;23719902;23845380;23929856;2405250;24220297;24275569;24305946;24681004;24966173;25067988;25208567;25248477;25253721;25372031;25576301;25595898;25703557;25716998;25813380;25843708;26015544;26280083;26284469;26300885;26416966;26549256;27128622;27203386;27255086;27397612;27705785;27760340;28085015;28163245;28169360;28278510;28301459;28317937;28394346;28512129;29242379;29295999;29356040;29557506;29999492;30315122;30629940;30716301;30779550;30804224;30936204;31092671;31154438;31286874;31373757;31473225;31831667;31844290;31848261;32157095;32350084;32543734;3263290;32636443;32795420;32938616;33537174;33596089;33744299;33968037;33981976;34087483;34140478;34171305;34185709;34215617;34217213;34742300;35051231;35115926;35154160;35580925;36309486;37770430;37986328;38974823;39009071;39244903;5338216;7075587;7505120;7510216;7512451;7525578;7531291;7541634;7542249;7542404;7543680;7547873;7559467;7601454;7685013;7806582;7958932;7961105;7982500;8033105;8075649;8093045;8118028;8127895;8140422;8178173;8185635;8226919;8234276;8336698;8344274;8459805;8560266;8601315;8626374;8626565;8662591;8662795;8672527;8756646;8797891;8798539;8798654;8838667;8910476;8985087;8995416;9045944;9065415;9115292;9148753;9168821;9199170;9199364;9219219;9251239;9285412;9314561;9353119;9368021;9440696;9443892;9461298;9537325;9560246;9565552;9676189;9694656;9700512;9730896;9744472;9760192;9845526;9852107;9858236;9973413",
        "class_list": "",
        "function": "(Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria., [UniProtKB, PubMed, PubMed, PubMed]; Biomarkers of epithelial-mesenchymal transition: E-cadherin and beta-catenin in malignant transformation of oral lesions. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane. Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7., [UniProtKB, UniProtKB]; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production., [UniProtKB, PubMed, UniProtKB, UniProtKB]; IL-8 promotes lens capsular residual cells migration by down-regulates expression of E-cadherin and ZO-1 via the CXCR1/2-NF-kappaB-RhoA signal pathway., [RefSeq, PubMed]; Molecular Crosstalk Between Adherens Junction Proteins, E-cadherin and Nectin-4., [RefSeq, PubMed]; This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 6,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 3,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 16,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 195,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "prognostic",
        "glycan_count": 2,
        "disease_count": 22,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1U7;Q13799;Q14216;Q15855;Q16194;Q4PJ14;Q9UII8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0050839 cell adhesion molecule binding;GO:0008013 beta-catenin binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0016477 cell migration;GO:0031175 neuron projection development;GO:0072659 protein localization to plasma membrane;GO:0030336 negative regulation of cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 44.7,
        "record_id": "P12830-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZSI9-1",
        "uniprot_id": "CAN12_HUMAN",
        "mass": 81037.0,
        "length": 719,
        "protein_name": "Calpain-12",
        "gene_name": "CAPN12",
        "organism": "Human",
        "refseq_name": "calpain-12",
        "refseq_ac": "NP_653292",
        "gene_names_uniprotkb": "CAPN12",
        "gene_names_refseq": "CAPN12",
        "protein_names_uniprotkb": "Calpain-12; 3.4.22.-; CANP 12; Calcium-activated neutral proteinase 12",
        "protein_names_refseq": "CANP 12; calcium-activated neutral proteinase 12; calpain-12",
        "tax_id": 9606,
        "disease": "hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:147968);  (R-HSA-1474228)",
        "pathway_count": 2,
        "publication_count": 51,
        "publication_id_list": "10229672;10386589;10706100;10809722;10986281;11237011;11375993;11872628;12727852;12843408;14973287;15234972;15591058;15958533;16133547;1649600;16631740;16825321;1698775;1707285;17332331;17354228;17608959;18434311;18658137;19010778;19571574;19657146;19714641;20142769;21030783;21297635;21441952;21670566;21784848;21864727;22159414;23035980;23845380;24715725;27769845;29557506;7075587;7547873;8226919;8626565;9065415;9115292;9148753;9461298;9852107",
        "class_list": "",
        "function": "Calcium-regulated non-lysosomal thiol-protease., [UniProtKB, UniProtKB, UniProtKB]; Calpain 12 plays an essential role during epidermal ontogenesis and normal hair follicle cycling., [RefSeq, PubMed]; The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "3.4.22.53;3.4.22.-;3.4.22.52;3.4.22.54",
        "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q6ZSI9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14444-1",
        "uniprot_id": "CAPR1_HUMAN",
        "mass": 78366.0,
        "length": 709,
        "protein_name": "Caprin-1",
        "gene_name": "CAPRIN1",
        "organism": "Human",
        "refseq_name": "caprin-1 isoform 1",
        "refseq_ac": "NP_005889",
        "gene_names_uniprotkb": "CAPRIN1; GPIAP1; GPIP137; M11S1; RNG105",
        "gene_names_refseq": "CAPRIN1; CONDCAC; GPIAP1; GPIP137; GRIP137; M11S1; NEDLAAD; RNG105; p137GPI",
        "protein_names_uniprotkb": "Caprin-1; Cell cycle-associated protein 1; Cytoplasmic activation- and proliferation-associated protein 1; GPI-anchored membrane protein 1; GPI-anchored protein p137; GPI-p137; Membrane component chromosome 11 surface marker 1; RNA granule protein 105; p137GPI",
        "protein_names_refseq": "GPI-anchored membrane protein 1; GPI-anchored protein p137; GPI-p137; RNA granule protein 105; activation/proliferation-associated protein 1; caprin 1; caprin-1 isoform 1; cytoplasmic activation- and proliferation-associated protein 1; cytoplasmic activation/proliferation-associated protein-1; membrane component chromosome 11 surface marker 1",
        "tax_id": 9606,
        "disease": "neurodegeneration, childhood-onset, with cerebellar ataxia and cognitive decline (MONDO:MONDO:0957985); neurodevelopmental disorder with language impairment, autism, and attention deficit-hyperactivity disorder (MONDO:MONDO:0968945)",
        "pathway": " (hsa:4076)",
        "pathway_count": 1,
        "publication_count": 167,
        "publication_id_list": "11237011;14764709;15471883;17210633;17924679;18669648;18991276;19651622;20068231;20112406;20305658;20516077;21872626;21933836;21993680;22424782;22544926;22645359;22898188;22967762;23097442;23186163;23301498;23481700;23783831;24129315;24275569;24714562;24715725;25418920;25469497;25502872;25505266;25576301;25645385;25880248;25892735;26154972;26375851;26768311;26929215;26992070;27022092;27452731;27543614;27600516;27846572;27893789;27920218;28063628;28218747;28228285;28514659;28604694;28649982;28733330;28832583;28834231;28855257;28904123;29242379;29331515;29351928;29371260;29393594;29437277;29485866;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30315122;30410026;30484775;30524438;30779550;30833945;31154438;31217245;31222486;31439799;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32302570;32302571;32302572;32350084;32357974;32373127;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33141586;33214551;33298915;33392160;33465208;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34074792;34087483;34171305;34185709;34211107;34229054;34405274;34509645;34561969;34725712;34846842;34932366;35051231;35083852;35132862;35138101;35154160;35251023;35254053;35318648;35561310;35580925;35977029;35979925;36010968;36040869;36136249;36183834;36215666;36241641;36279435;36284347;36580660;37052473;37161291;37217939;37316325;37938771;38082307;38665916;39079611;39302247;39531497;39534244;40596516;40914422;7657653;8786113",
        "class_list": "",
        "function": "CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma., [RefSeq, PubMed]; Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH., [RefSeq, PubMed]; Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Caprin1 Bridges PRMT1 to G3BP1 and Spaces Them to Ensure Proper Stress Granule Formation., [RefSeq, PubMed]; Homologous region-1 (HR-1) is a novel protein domain that has been identified near the N-terminus of human caprin-1; highly conserved in vertebrates and insects, it is also present in the human caprin-2 paralog., [RefSeq, PubMed]; Involvement of cellular protein p137 in transcription of intermediate stage genes may regulate the transition between early and late phases of vaccinia virus replication, [RefSeq, PubMed]; mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 20,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 22,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 22,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 25,
        "reported_mutagensis": 93,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 22,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NMY7;D3DR06;Q15074;Q6IMN4;Q6IMN7;Q9BV09",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0035591 signaling adaptor activity;GO:0140693 molecular condensate scaffold activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0030027 lamellipodium;GO:0030425 dendrite",
        "go_biological_process": "GO:0030154 cell differentiation;GO:0017148 negative regulation of translation;GO:0050775 positive regulation of dendrite morphogenesis;GO:0061003 positive regulation of dendritic spine morphogenesis;GO:0062029 positive regulation of stress granule assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 19.1,
        "record_id": "Q14444-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5SNV9-1",
        "uniprot_id": "CA167_HUMAN",
        "mass": 160482.0,
        "length": 1449,
        "protein_name": "Uncharacterized protein C1orf167",
        "gene_name": "C1orf167",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C1orf167 isoform 1",
        "refseq_ac": "NP_001010881",
        "gene_names_uniprotkb": "C1orf167",
        "gene_names_refseq": "C1orf167",
        "protein_names_uniprotkb": "Uncharacterized protein C1orf167",
        "protein_names_refseq": "uncharacterized protein C1orf167 isoform 1; uncharacterized protein C1orf167",
        "tax_id": 9606,
        "disease": "stroke (Disease Ontology:DOID:0051061); coronary artery disease (Disease Ontology:DOID:3393)",
        "pathway": " (hsa:284498)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;19729601;20416077;37217939",
        "class_list": "",
        "function": "Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A8I5KXP5;Q8NDA9;Q8NDF3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q5SNV9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P59901-1",
        "uniprot_id": "LIRA4_HUMAN",
        "mass": 55181.0,
        "length": 499,
        "protein_name": "Leukocyte immunoglobulin-like receptor subfamily A member 4",
        "gene_name": "LILRA4",
        "organism": "Human",
        "refseq_name": "leukocyte immunoglobulin-like receptor subfamily A member 4 precursor",
        "refseq_ac": "NP_036408",
        "gene_names_uniprotkb": "LILRA4; ILT7",
        "gene_names_refseq": "CD85g; ILT7; LILRA4",
        "protein_names_uniprotkb": "Leukocyte immunoglobulin-like receptor subfamily A member 4; CD85 antigen-like family member G; ILT-7; Immunoglobulin-like transcript 7",
        "protein_names_refseq": "CD85 antigen-like family member G; immunoglobulin-like transcript 7; leucocyte Ig-like receptor A4; leukocyte immunoglobulin-like receptor subfamily A member 4 precursor; leukocyte immunoglobulin-like receptor subfamily A member 4; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23547);  (R-HSA-198933)",
        "pathway_count": 2,
        "publication_count": 89,
        "publication_id_list": "10499918;10746781;11237011;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12213321;12384430;12483297;12588680;14719373;14970179;15034010;15136729;15155468;15187158;15304001;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;16014749;16091383;16129954;16339513;16380601;16551255;16735691;16737824;16754721;16777052;16893496;16904340;16928187;17045824;17057721;17237375;17337780;18031695;18037897;18055229;18209062;18234675;18593354;19149696;19359216;19564354;19592130;20730098;21241660;21800138;21841309;21877119;22396535;22674796;23401591;23695528;23929856;24190977;24305946;24586760;25703557;25716998;26172439;26284469;26300885;29632711;31998317;7531291;7542404;8178173;8995416;9285412;9314561;9700512;9730896",
        "class_list": "",
        "function": "Crosslinked ILT7 favours the differentiation of immature plasmacytoid dendritic cells into antigen-presenting cells rather than IPC. Publication Status: Online-Only, [RefSeq, PubMed]; Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; ILT7 may exert its immunomodulatory activity only on immature circulating plasmacytoid dendritic cells (pDCs), providing a basic homeostatic mechanism rather than negative feedback control on activated pDCs., [RefSeq, PubMed]; Intracellular expression of the TCL1 as well as membrane and intracellular expression of ILT7 in plasmacytoid dendritic cell leukemia (pDCL) samples and 61 non-pDC acute leukemia samples, were tested., [RefSeq, PubMed]; The expression of immunoglobulin-like transcript 7, in plasmacytoid dendritic cells, [RefSeq, PubMed]; This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q32MC4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:0032396 inhibitory MHC class I receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0032998 Fc-epsilon receptor I complex",
        "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0045087 innate immune response;GO:0032720 negative regulation of tumor necrosis factor production;GO:0019221 cytokine-mediated signaling pathway;GO:0038095 Fc-epsilon receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 9.2,
        "record_id": "P59901-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P19022-1",
        "uniprot_id": "CADH2_HUMAN",
        "mass": 99809.0,
        "length": 906,
        "protein_name": "Cadherin-2",
        "gene_name": "CDH2",
        "organism": "Human",
        "refseq_name": "cadherin-2 isoform 2",
        "refseq_ac": "NP_001295105",
        "gene_names_uniprotkb": "CDH2; CDHN; NCAD",
        "gene_names_refseq": "ACOGS; ADHD8; ARVD14; CD325; CDH2; CDHN; CDw325; NCAD",
        "protein_names_uniprotkb": "Cadherin-2; CDw325; N-cadherin; Neural cadherin",
        "protein_names_refseq": "N-cadherin 1; cadherin 2, type 1, N-cadherin (neuronal); cadherin-2 isoform 2; calcium-dependent adhesion protein, neuronal; neural cadherin",
        "tax_id": 9606,
        "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); agenesis of corpus callosum, cardiac, ocular, and genital syndrome (Disease Ontology:DOID:0080948); arrhythmogenic right ventricular dysplasia 14 (Disease Ontology:DOID:0080959); prostate cancer (Disease Ontology:DOID:10283); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); cancer (Disease Ontology:DOID:162); attention deficit-hyperactivity disorder 8 (MONDO:MONDO:0859261)",
        "pathway": " (hsa:1000);  (R-HSA-381426);  (R-HSA-418990);  (R-HSA-525793);  (R-HSA-8957275);  (R-HSA-9926550)",
        "pathway_count": 6,
        "publication_count": 157,
        "publication_id_list": "10.1101/2023.09.13.557529;10026136;10077652;10218588;10225955;10330143;10512690;10601328;10614670;10681634;10805738;10810289;10898936;10912521;10951195;10990447;11158056;11237011;11250653;11264294;11316783;11518510;11522292;11606061;11739083;11751371;11782431;11788658;12050160;12241545;12379487;12466191;12634428;12810533;12904166;1370451;1383255;15001579;1500442;15126567;15308688;15469690;15485880;15525596;15642270;16007225;16212419;16371504;16467305;17047378;17249697;17312271;17967169;17985932;18077418;18702456;19159218;19354288;19564926;19590037;19940119;20160094;20418909;21654843;2216790;22299025;23090970;23271734;23292232;23345538;2384753;23863954;24190977;24715725;2476804;2479552;25372031;25576301;25645385;25771201;26091039;27862975;27864899;28169360;28280076;28326674;29242379;29391424;29557506;30716301;30833945;31154438;31585109;31650526;31831667;31844290;32157095;32161166;32162841;32387766;32488085;32543734;32938616;33592498;33691108;33936100;33968037;33981976;34019948;34078123;34171305;34217213;34433824;34702855;35051231;35154160;35254053;35580925;36241641;37074911;37986328;38127465;38169592;38253038;38370408;38477830;39534244;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;7806582;7959764;8781553;8817670;8894645;8964575;9069290;9168821;9219219;9418854;9497324;9709957;9733769;9786878;9786951;9845526;9858528;9922210;9988769",
        "class_list": "",
        "function": "Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB]; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells. Required for proper neurite branching. Required for pre- and postsynaptic organization. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Essential role of obscurin kinase-1 in cardiomyocyte coupling via N-cadherin phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; Existing knowledge regarding the role of CDH2 and CDH11 during development and differentiation in vivo and in vitro is reviewed. [review] Review article, [RefSeq, PubMed]; N-cadherin Alleviates Apoptosis and Senescence of Nucleus Pulposus Cells via Suppressing ROS-dependent ERS in the Hyper-osmolarity Microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]; N-cadherin dynamically regulates pediatric glioma cell migration in complex environments., [RefSeq, PubMed]; The gene expression of CALD1, CDH2, and POSTN in fibroblast are related to idiopathic pulmonary fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 9,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 9,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 9,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
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        "reported_snv": 58,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 37,
        "disease_count": 7,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MWK3;B0YIY6;Q14923;Q8N173",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction",
        "go_biological_process": "GO:0035995 detection of muscle stretch;GO:0097091 synaptic vesicle clustering;GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0000902 cell morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 20.9,
        "record_id": "P19022-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BWV1-1",
        "uniprot_id": "BOC_HUMAN",
        "mass": 121059.0,
        "length": 1114,
        "protein_name": "Brother of CDO",
        "gene_name": "BOC",
        "organism": "Human",
        "refseq_name": "brother of CDO isoform 1 precursor",
        "refseq_ac": "NP_001288790",
        "gene_names_uniprotkb": "BOC; PRO1190",
        "gene_names_refseq": "BOC; Boi; CDON2",
        "protein_names_uniprotkb": "Brother of CDO; Protein BOC",
        "protein_names_refseq": "Boc homolog; brother of CDO isoform 1 precursor; brother of CDON; brother of CDO; cell adhesion associated, oncogene regulated 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91653);  (R-HSA-5632681);  (R-HSA-5635838)",
        "pathway_count": 3,
        "publication_count": 80,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10050855;10966113;11237011;11782431;11841368;12569124;12634428;12720294;12975309;14614827;14636583;15019948;15294024;15340161;15618519;15691767;16136078;16630821;16647304;16908539;16959974;17086203;17504940;17504941;17641202;17960137;18497258;18559595;18794898;18815277;19196978;19218434;19365551;19561609;19561611;19948480;20519495;20844013;20844016;21356043;21659505;21664576;21664577;21695114;21802063;21842183;22277298;22326621;22981989;22986504;23026747;23584533;23719536;23877428;23900540;24582806;24845016;24925320;25505266;27862975;27871935;28677295;28915250;29393594;29557506;30429286;30459171;31848261;32651845;32938616;33592498;33958541;34087483;35051231;37074911;8898207;8906787;8906794",
        "class_list": "",
        "function": "BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth., [RefSeq, PubMed]; BOC, along with CDO, defines a new subfamily of the immunoglobulin superfamily that is conserved from Drosophila to man. BOC and CDO form a putative receptor complex that stimulates differentiation of myoblasts., [RefSeq, PubMed]; CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage, [RefSeq, PubMed]; Elevated plasma endocan and BOC in heart failure patients decrease after heart transplantation in association with improved hemodynamics., [RefSeq, PubMed]; Female-Specific Susceptibility Locus in BOC and SEC16B are Associated with Adolescent Idiopathic Scoliosis., [RefSeq, PubMed]; Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]., [RefSeq]; Together with CDON, forms a coreceptor required for sonic hedgehog (SHH) handoff to its patched receptor (PTCH1 or PTCH2), thereby allowing activation of the smoothened signaling pathway (By similarity). Binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) downstream of SCUBE2 carrier and promotes its release to GAS1 (By similarity). ShhN is then directly transferred to patched receptor by GAS1 (By similarity). May also mediate cell-cell interactions between muscle precursor cells, promoting differentiation of myogenic cells (By similarity)., [UniProtKB, UniProtKB]; We report the identification of missense BOC variants in HPE patients. Consistent with these alleles functioning as HPE modifiers, individual variant BOC proteins had either loss- or gain-of-function properties in cell-based SHH signaling assays., [RefSeq, PubMed]",
        "predicted_glycosites": 6,
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        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
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        "reported_snv": 53,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 0,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJ30;B2RMS8;D3DN70;Q6UXJ5;Q8N2P7;Q8NF26",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0044295 axonal growth cone",
        "go_biological_process": "GO:0007399 nervous system development;GO:0098609 cell-cell adhesion;GO:0007411 axon guidance;GO:0045663 positive regulation of myoblast differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "Q9BWV1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZNA4-1",
        "uniprot_id": "RN111_HUMAN",
        "mass": 108862.0,
        "length": 994,
        "protein_name": "E3 ubiquitin-protein ligase Arkadia",
        "gene_name": "RNF111",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase Arkadia isoform 3",
        "refseq_ac": "NP_001257458",
        "gene_names_uniprotkb": "RNF111",
        "gene_names_refseq": "ARK; RNF111; hRNF111",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Arkadia; 2.3.2.27; RING finger protein 111; RING-type E3 ubiquitin transferase Arkadia; hRNF111",
        "protein_names_refseq": "Arkadia; E3 ubiquitin-protein ligase Arkadia isoform 3; E3 ubiquitin-protein ligase Arkadia; RING-type E3 ubiquitin transferase Arkadia",
        "tax_id": 9606,
        "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)",
        "pathway": " (hsa:54778);  (R-HSA-2173795);  (R-HSA-2173796);  (R-HSA-5696395);  (R-HSA-983168)",
        "pathway_count": 5,
        "publication_count": 157,
        "publication_id_list": "10022869;10197981;10199400;10485843;10526214;10531062;10535941;10549282;10587642;10587654;10734143;11007478;11007770;11013220;11062501;11141066;11237011;11274402;11278856;11298452;11298453;11350924;11389444;11424093;11427533;11511374;12080057;12150994;12446674;12646216;12917425;14517266;14657019;14734113;15100235;15150273;15220921;15224091;15224092;15571818;15590680;15820681;16030353;16156666;16278212;16319104;16491090;16595681;16601693;16751101;16751102;16849449;16954532;17000769;17438144;17466625;17466626;17510063;17591695;17592128;17948053;18568018;18614043;18662542;19028597;19056823;19135894;19352404;19452197;19489725;19661379;19713942;19851334;19874575;19914168;19917253;19940136;19940261;19941824;20368362;20595680;20876134;21095583;22045334;22081108;22275377;22411132;2261476;22645359;23038248;23045548;23086935;23352696;23751493;25154395;25538220;25576301;25645385;25755297;26042670;26151477;26656854;26992070;27153775;27846572;27920218;28228285;28514659;28832583;28834231;28855257;28904123;29242379;29493099;29557506;29577978;29786170;30315122;30379171;30429286;31092671;31217245;31844290;31936902;32157095;32357974;32488085;32897882;32938616;32983136;33298915;33537174;33592498;33691108;33912179;33968037;33981976;34171305;34185709;34740826;35051231;35561310;35580925;36010968;36241641;36284347;38665916;38874713;7559382;7700386;8692841;9130708;9380723;9668046;9699634;9716411;9771713",
        "class_list": "",
        "function": "Deleterious variants in RNF111 impair female fertility and induce premature ovarian insufficiency in humans and mice., [RefSeq, PubMed]; E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Functional analysis of the mouse counterpart, [RefSeq, PubMed, PubMed]; Quantitative Ubiquitylome Analysis Reveals the Specificity of RNF111/Arkadia E3 Ubiquitin Ligase for its Degradative Substrates SKI and SKIL/SnoN in TGF-beta Signaling Pathway., [RefSeq, PubMed]; Silencing of the Arkadia gene resulted in repression of transcriptional activities induced by TGF-beta and BMP, and accumulation of the Smad7 protein., [RefSeq, PubMed]; The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 19,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JUS4;H0YN55;Q6P9A4;Q6ZMU2;Q7L428;Q7Z346;Q8N1P9;Q8WUA3;Q9NSR1",
        "ec_number_list": "2.3.2.24;2.3.2.23;2.3.2.26;2.3.2.27;2.3.2.31;2.3.2.-;2.4.2.-;2.4.2.30;5.6.2.3;5.6.2.4;6.2.1.-;1.14.11.-;2.3.2.34;2.3.2.32;3.6.4.-;2.3.2.25;2.3.2.36;2.7.11.1",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0046332 SMAD binding;GO:0032184 SUMO polymer binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016605 PML body",
        "go_biological_process": "GO:0016567 protein ubiquitination;GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070911 global genome nucleotide-excision repair",
        "synthesized_glycan_count": 0,
        "hit_score": 16.0,
        "record_id": "Q6ZNA4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51965-1",
        "uniprot_id": "UB2E1_HUMAN",
        "mass": 21404.0,
        "length": 193,
        "protein_name": "Ubiquitin-conjugating enzyme E2 E1",
        "gene_name": "UBE2E1",
        "organism": "Human",
        "refseq_name": "ubiquitin-conjugating enzyme E2 E1 isoform 3",
        "refseq_ac": "NP_001189405",
        "gene_names_uniprotkb": "UBE2E1; UBCH6",
        "gene_names_refseq": "UBCH6; UBE2E1",
        "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 E1; (E3-independent) E2 ubiquitin-conjugating enzyme E1; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme E1; UbcH6; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1",
        "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme E1; E2 ubiquitin-conjugating enzyme E1; ubiquitin carrier protein E1; ubiquitin conjugating enzyme E2E 1; ubiquitin-conjugating enzyme E2 E1 isoform 3; ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2E 1 (homologous to yeast UBC4/5); ubiquitin-protein ligase E1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7324);  (R-HSA-1169408);  (R-HSA-141430);  (R-HSA-174048);  (R-HSA-174084);  (R-HSA-174154);  (R-HSA-174178);  (R-HSA-174184);  (R-HSA-176407);  (R-HSA-176408);  (R-HSA-176409);  (R-HSA-176412);  (R-HSA-179409);  (R-HSA-2467813);  (R-HSA-2559582);  (R-HSA-68867);  (R-HSA-69017);  (R-HSA-8853884);  (R-HSA-8866652);  (R-HSA-8866654);  (R-HSA-9687136);  (R-HSA-983168)",
        "pathway_count": 22,
        "publication_count": 227,
        "publication_id_list": "10201372;10318916;10339564;10358176;10411507;10432220;10548110;10562279;10679238;10733526;10793135;10884341;10995389;11046155;11062501;11081627;11095724;11112487;11114305;11125146;11157743;11237011;11248027;11285280;11340163;11350924;11371342;11509732;11535616;11562349;11598127;11740563;11742988;11788588;11859075;11988738;12006501;12070128;12194817;12446569;12525615;12582176;12646216;12832467;14657031;14672932;14679213;14734113;14743218;15014503;15029244;15131269;15215855;15215856;15224091;15224092;15469821;15485925;15571818;15678131;15702989;15737063;15774718;16009940;16112642;16122702;16139798;16142244;16307923;16352599;16407192;16413484;16428300;16595681;16626623;16648845;16699525;16715065;16775314;16815975;16824194;16849449;16868077;16872604;16914094;16954532;17108083;17130289;17187060;17234884;17289916;17376915;17485488;17580310;17588522;17597759;17697703;17726030;18267069;18287095;18305167;18316726;18353650;18359941;18411265;18485873;18555777;18555778;18583345;18662542;18719106;18845142;19028597;19073728;19125153;19208625;19270716;19352404;19410543;19413330;19452197;19489725;19723507;19805069;19851334;19874575;19896182;19940261;20028861;20061386;20133869;20219937;20308324;20351173;20385878;20452968;21203937;21325273;21329877;21396873;21554508;21670496;2183031;21979375;22021426;22084091;22178396;22496338;2261476;22634325;22869377;22885700;23603117;23846687;23851460;2405250;24662292;24706756;24807418;24979766;25030448;25170678;25231993;25576301;25892735;25936802;26086376;26154972;26210183;26216882;26222030;26235645;26344566;26350214;26375851;26711259;26992070;27237050;27249176;27569044;27597759;27798111;28832583;29242379;30282802;30315122;30429286;30484775;30779550;31154438;31160341;31217245;31844290;31848261;31937595;32161166;32387766;32488085;32502341;33392160;34357683;36215666;36284347;6277905;6305978;7559393;7734418;7851534;8010951;8234276;8384717;8413215;8413306;8576257;8617720;8625414;8688489;8884985;8939459;8991089;9029102;9380723;9521656;9525617;9635433;9668046;9892021",
        "class_list": "",
        "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Catalyzes monoubiquitination of other proteins in both an E3-dependent and E3-independent manner (PubMed:27237050)., [UniProtKB, PubMed, PubMed, PubMed]; Found that critical UBE2E1 residues involved in the capture of the TRIM21 substrate lysine are conserved in ubiquitin-conjugating E2s, whereas residues critical for SUMOylation are not conserved, [RefSeq, PubMed]; Isolated ISG15-modified and unmodified UbcH6 proteins, and analyzed their abilities to form thioester intermediates with ubiquitin, [RefSeq, PubMed]; OTUB1 depletion dramatically destabilizes the E2-conjugating enzyme UBE2E1 in both mouse and human OTUB1 knockout cell lines., [RefSeq, PubMed]; The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBX4;C9J8K2;K4DI90",
        "ec_number_list": "6.2.1.45;3.4.19.12;2.3.2.24;2.3.2.23;2.7.11.1;2.3.2.26;2.3.2.27;2.3.2.31;2.3.2.-;3.6.4.13;2.7.11.22;2.7.11.23;3.1.4.11;2.7.10.2;2.7.11.24;3.4.25.1;6.2.1.-;2.7.11.21;2.3.2.34;2.3.2.32;6.3.2.n3;3.6.4.-;6.2.1.64;2.3.2.25;2.1.1.-;2.1.1.367;2.3.2.36",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0042296 ISG15 transferase activity;GO:0061631 ubiquitin conjugating enzyme activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 22.8,
        "record_id": "P51965-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P13569-1",
        "uniprot_id": "CFTR_HUMAN",
        "mass": 168142.0,
        "length": 1480,
        "protein_name": "Cystic fibrosis transmembrane conductance regulator",
        "gene_name": "CFTR",
        "organism": "Human",
        "refseq_name": "cystic fibrosis transmembrane conductance regulator",
        "refseq_ac": "NP_000483",
        "gene_names_uniprotkb": "CFTR; ABCC7",
        "gene_names_refseq": "ABC35; ABCC7; CFTR/MRP; CFTR; CF; MRP7; TNR-CFTR; dJ760C5.1",
        "protein_names_uniprotkb": "Cystic fibrosis transmembrane conductance regulator; 5.6.1.6; ATP-binding cassette sub-family C member 7; CFTR; Channel conductance-controlling ATPase; cAMP-dependent chloride channel",
        "protein_names_refseq": "cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulating; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator",
        "tax_id": 9606,
        "disease": "sinusitis (Disease Ontology:DOID:0050127); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); bronchiectasis 1 (Disease Ontology:DOID:0080526); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); congenital bilateral absence of vas deferens (Disease Ontology:DOID:0111862); autosomal recessive congenital bilateral absence of vas deferens (Disease Ontology:DOID:0111864); cholelithiasis (Disease Ontology:DOID:10211); Alzheimer's disease (Disease Ontology:DOID:10652); gastric ulcer (Disease Ontology:DOID:10808); prostatic hypertrophy (Disease Ontology:DOID:11132); osteoporosis (Disease Ontology:DOID:11476); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); lung cancer (Disease Ontology:DOID:1324); typhoid fever (Disease Ontology:DOID:13258); exocrine pancreatic insufficiency (Disease Ontology:DOID:13316); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); duodenal ulcer (Disease Ontology:DOID:1724); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); alcoholic pancreatitis (Disease Ontology:DOID:4988); salpingitis (Disease Ontology:DOID:5733); dental enamel hypoplasia (Disease Ontology:DOID:693); gastrointestinal system disease (Disease Ontology:DOID:77); lung disease (Disease Ontology:DOID:850); diabetes mellitus (Disease Ontology:DOID:9351); bronchiectasis (Disease Ontology:DOID:9563)",
        "pathway": " (hsa:1080);  (R-HSA-382556);  (R-HSA-5627083);  (R-HSA-5678895);  (R-HSA-5689880);  (R-HSA-8856825);  (R-HSA-8856828);  (R-HSA-9013406);  (R-HSA-9613829);  (R-HSA-9615710);  (R-HSA-9646399);  (R-HSA-9925563)",
        "pathway_count": 12,
        "publication_count": 544,
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        "class_list": "",
        "function": "Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Insights and considerations on CFTR variant reporting in a study of cystic fibrosis patients in Saudi Arabia CFTR 1548del G and 1549del G: Navigating the discovery of novel mutations., [RefSeq, PubMed]; Loss of CFTR Reverses Senescence Hallmarks in SARS-CoV-2 Infected Bronchial Epithelial Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Mutation accumulation in H. sapiens F508del CFTR countermands dN/dS type genomic analysis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. [provided by RefSeq, Aug 2017]., [RefSeq]",
        "predicted_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 53,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 57,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 29,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q20BG8;Q20BH2;Q2I0A1;Q2I102",
        "ec_number_list": "5.6.2.4;3.6.5.-;3.6.1.-;3.6.4.-;3.6.4.13;1.8.-.-;1.8.5.1;2.7.1.153;2.7.1.137;2.7.1.154;3.4.19.12;2.7.11.1;1.11.1.-;7.6.2.2;7.6.2.-;7.6.2.3;2.3.2.31;3.1.3.-;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;2.7.10.1;4.2.1.1;4.2.1.69;3.1.3.1;3.9.1.1;4.6.1.18;4.2.99.18;5.6.1.6;3.6.5.2;5.6.2.3;2.3.2.27;3.6.4.12;3.4.25.1;3.4.21.53;5.6.2.5;3.6.5.5;3.1.-.-;2.3.2.23;7.6.2.1;3.1.3.86;3.1.3.56;3.1.3.36;7.2.2.-;5.6.2.-;2.3.2.-;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.2.-;3.5.1.-;3.5.1.124;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0005260 intracellularly ATP-gated chloride channel activity;GO:0019869 chloride channel inhibitor activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042626 ATPase-coupled transmembrane transporter activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0055085 transmembrane transport;GO:0071320 cellular response to cAMP;GO:1904322 cellular response to forskolin;GO:0048240 sperm capacitation;GO:1902476 chloride transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 54.7,
        "record_id": "P13569-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96FJ2-1",
        "uniprot_id": "DYL2_HUMAN",
        "mass": 10350.0,
        "length": 89,
        "protein_name": "Dynein light chain 2, cytoplasmic",
        "gene_name": "DYNLL2",
        "organism": "Human",
        "refseq_name": "dynein light chain 2, cytoplasmic",
        "refseq_ac": "NP_542408",
        "gene_names_uniprotkb": "DYNLL2; DLC2",
        "gene_names_refseq": "DNCL1B; DYNLL2; Dlc2; RSPH22",
        "protein_names_uniprotkb": "Dynein light chain 2, cytoplasmic; 8 kDa dynein light chain b; DLC8b; Dynein light chain LC8-type 2",
        "protein_names_refseq": "8 kDa dynein light chain b; DLC8b; dynein light chain 2, cytoplasmic; radial spoke 22 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:140735);  (R-HSA-139910);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-1632852);  (R-HSA-2132295);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-3371497);  (R-HSA-5620924);  (R-HSA-5663220);  (R-HSA-6807878);  (R-HSA-6811436);  (R-HSA-68877);  (R-HSA-9609690);  (R-HSA-9646399);  (R-HSA-9648025)",
        "pathway_count": 17,
        "publication_count": 461,
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        "class_list": "",
        "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5B4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0097110 scaffold protein binding;GO:0045505 dynein intermediate chain binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0031475 myosin V complex;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0003341 cilium movement;GO:0032388 positive regulation of intracellular transport;GO:0035721 intraciliary retrograde transport;GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint",
        "synthesized_glycan_count": 0,
        "hit_score": 46.4,
        "record_id": "Q96FJ2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96A65-1",
        "uniprot_id": "EXOC4_HUMAN",
        "mass": 110498.0,
        "length": 974,
        "protein_name": "Exocyst complex component 4",
        "gene_name": "EXOC4",
        "organism": "Human",
        "refseq_name": "exocyst complex component 4 isoform a",
        "refseq_ac": "NP_068579",
        "gene_names_uniprotkb": "EXOC4; KIAA1699; SEC8L1; SEC8",
        "gene_names_refseq": "EXOC4; SEC8L1; SEC8; Sec8p",
        "protein_names_uniprotkb": "Exocyst complex component 4; Exocyst complex component Sec8",
        "protein_names_refseq": "SEC8-like 1; exocyst complex component 4 isoform a; exocyst complex component Sec8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:60412);  (R-HSA-1445148);  (R-HSA-264876);  (R-HSA-5620916)",
        "pathway_count": 4,
        "publication_count": 186,
        "publication_id_list": "10.1101/2023.09.13.557529;10521251;11462236;11493706;11707400;11904301;12221131;14617756;14704853;15158452;1528899;15331542;15728366;15878854;15919790;15971998;16038802;16136078;16155582;16158220;16158222;16213214;16407158;16431365;16537653;16714477;16782012;16880201;16959974;16964243;16984975;17007872;17030804;17369524;17574030;17628206;17646400;17956946;17995453;18329369;18669648;18685082;19006485;19013499;19017632;19153612;19252894;19297529;19454479;19608861;19690332;20068231;20083215;20112406;20230923;20308425;20308558;20631154;20701589;20837646;20937701;21091435;21145486;21273506;21308844;21454505;21454690;21550243;21565611;21658605;21713314;21775626;21907143;22389062;22420621;22424782;22433857;22544926;22706990;22983554;23186163;23351793;23481700;23567335;23945166;24275569;24296415;24366607;24397554;24714562;24715725;25091901;2550440;25505266;25576301;25645385;25880248;26154972;26375851;26638075;2669954;26811146;26929215;26992070;27397612;27600516;27846572;27862975;27920218;28063628;28218747;2822027;28228285;28446606;28510447;28649982;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29786170;30315122;30410026;30429286;30524438;30779550;31184304;31217245;31844290;32157095;32265295;32357974;32387766;32488085;32502341;32723473;32897882;32938616;32983136;33141586;33298915;33392160;33485965;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34561969;34725712;34932366;35051231;35318648;35471457;35561310;35580925;36010968;36180927;36241641;36284347;37938771;3896518;40914422;7626024;8094051;8664345;8916141;9166668;9207799;9631292;9819391",
        "class_list": "",
        "function": "Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB, UniProtKB]; EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal., [RefSeq, PubMed]; The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PED2;Q541U8;Q9C0G4;Q9H9K0;Q9P102",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0030742 GTP-dependent protein binding",
        "go_cellular_component": "GO:0035748 myelin sheath abaxonal region;GO:0032584 growth cone membrane;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0015031 protein transport;GO:0007268 chemical synaptic transmission;GO:0016241 regulation of macroautophagy;GO:0000281 mitotic cytokinesis;GO:0006887 exocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 19.1,
        "record_id": "Q96A65-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q08209-1",
        "uniprot_id": "PP2BA_HUMAN",
        "mass": 58688.0,
        "length": 521,
        "protein_name": "Protein phosphatase 3 catalytic subunit alpha",
        "gene_name": "PPP3CA",
        "organism": "Human",
        "refseq_name": "protein phosphatase 3 catalytic subunit alpha isoform 1",
        "refseq_ac": "NP_000935",
        "gene_names_uniprotkb": "PPP3CA; CALNA; CNA",
        "gene_names_refseq": "ACCIID; CALNA1; CALNA; CALN; CNA1; DEE91; IECEE1; IECEE; PPP2B; PPP3CA",
        "protein_names_uniprotkb": "Protein phosphatase 3 catalytic subunit alpha; 3.1.3.16; CAM-PRP catalytic subunit; CNA alpha; Calcineurin A alpha; Calmodulin-dependent calcineurin A subunit alpha isoform; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform",
        "protein_names_refseq": "CAM-PRP catalytic subunit; CNA alpha; calcineurin A alpha; protein phosphatase 3 catalytic subunit alpha isoform 1; protein phosphatase 3 catalytic subunit alpha isozyme",
        "tax_id": 9606,
        "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); developmental and epileptic encephalopathy 91 (Disease Ontology:DOID:0080472); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557); arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development (MONDO:MONDO:0032642)",
        "pathway": " (hsa:5530);  (R-HSA-180024);  (R-HSA-2025928);  (R-HSA-2871809);  (R-HSA-4086398);  (R-HSA-5607763)",
        "pathway_count": 6,
        "publication_count": 167,
        "publication_id_list": "10380924;10391246;10391247;10395542;10488343;10588714;10604473;10777564;10858654;10860980;11015615;11015619;11030334;11114196;11231878;11237011;11395409;11563835;11842093;12015605;12065642;12086864;12218175;12357034;12471263;12482967;12556497;12573241;12729560;12809556;12975316;14704854;14977528;15454081;15494017;15545263;15611108;15671020;16880514;16920709;1715244;17426020;17498738;17502104;17535922;17684012;17923693;18296442;18384083;18456304;18488142;18838687;19054851;19154138;19177143;19404396;19536106;19851316;20590401;21118996;21647268;21903638;22343722;22424782;22941947;23151663;23186163;23256519;23416699;23468591;23481700;23632248;23904219;2445721;24715725;25144868;25576301;25645385;26154972;26248042;26590425;27974827;2841328;28467828;28832583;28881575;28904123;28942967;29242379;29314611;29432562;29493099;29508533;29557506;29632711;30254215;30294901;30315122;30524438;30573663;30611118;30718414;30779550;31154438;31217245;31375679;31844290;31848261;32157095;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33691586;33912179;33936100;33968037;33981976;34087483;34211107;34357683;34509645;34561969;34725712;34795676;34932366;35008409;35051231;35251023;35318648;35324524;35580925;36010968;36241641;36525928;38253038;38665916;40596516;40914422;6087160;6296685;6330098;6501302;7518558;7657645;8392375;8524402;8576111;8629002;8630736;8631904;8663227;8684469;8799126;9073455;9099992;9106655;9312192;9371714;9389482;9727000",
        "class_list": "",
        "function": "Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118). Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed:33691586). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (PubMed:30718414). Negatively regulates SLC9A1 activity (PubMed:31375679)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Dephosphorylation of the EGFR protein by calcineurin at serine 1046/1047 enhances its stability., [RefSeq, PubMed]; Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter? Review article Publication Status: Online-Only, [RefSeq, PubMed]; TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A441;A8K3B7;A8W6Z7;A8W6Z8;B5BUA2;Q8TAW9",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.-;3.1.3.67;3.1.3.53;5.2.1.8;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0046983 protein dimerization activity;GO:0051117 ATPase binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0097720 calcineurin-mediated signaling;GO:0016311 dephosphorylation;GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress;GO:1905205 positive regulation of connective tissue replacement",
        "synthesized_glycan_count": 0,
        "hit_score": 17.1,
        "record_id": "Q08209-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P04004-1",
        "uniprot_id": "VTNC_HUMAN",
        "mass": 54306.0,
        "length": 478,
        "protein_name": "Vitronectin",
        "gene_name": "VTN",
        "organism": "Human",
        "refseq_name": "vitronectin precursor",
        "refseq_ac": "NP_000629",
        "gene_names_uniprotkb": "VTN",
        "gene_names_refseq": "V75; VNT; VN; VTN",
        "protein_names_uniprotkb": "Vitronectin; S-protein; Serum-spreading factor; V75; VN",
        "protein_names_refseq": "complement S-protein; epibolin; serum spreading factor; somatomedin B; vitronectin precursor",
        "tax_id": 9606,
        "disease": "thrombosis (Disease Ontology:DOID:0060903); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); Churg-Strauss syndrome (Disease Ontology:DOID:3049); coronary artery disease (Disease Ontology:DOID:3393); proteinuria (Disease Ontology:DOID:576); diabetic retinopathy (Disease Ontology:DOID:8947)",
        "pathway": " (hsa:7448);  (R-HSA-2129379);  (R-HSA-216083);  (R-HSA-3000170);  (R-HSA-3000178);  (R-HSA-977606);  (R-HSA-9920588);  (R-HSA-9925563)",
        "pathway_count": 8,
        "publication_count": 258,
        "publication_id_list": "10.1021/acs.analchem.6b02887;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10022829;10025398;10209034;10339611;10366422;10424889;10438935;10531307;10543983;10544250;10593924;10605720;10640428;10646116;10673326;10673366;1067618;10713152;10811134;10930463;10982388;11084047;11158588;11237011;11259413;11518510;11572855;11694537;11713259;11939578;11970960;11980922;12019263;12055245;12225811;12358597;12415008;12429738;12496264;12585966;12682293;12807887;12808446;12975610;1376317;1386357;1400330;14681059;14701737;14715956;14760718;14976204;15075323;15240572;15296743;15330449;15345499;15383545;1544908;15479743;15713743;1588291;15899827;16002701;16051604;16079145;16192651;16239428;16293224;16335952;16493581;16731529;16754661;16807684;16933105;16945929;1696913;16999828;1704366;1706595;17081983;1708799;1709100;17182573;17314405;17324935;17339034;17505110;17558413;17588949;17968485;18088087;18339631;18496526;18710925;18775695;19139490;19159218;19502598;19754307;19824718;19899825;20033473;2010551;2059554;20705068;21081667;21566123;21642437;21646718;21788512;21789315;22121020;22134916;22539938;22802338;22884367;23090970;23374253;23487775;2364322;23719902;2412224;2414098;24173023;2420006;2420889;24275569;24279413;2430969;2447940;2448300;24628331;2465906;2466593;2479556;2481448;25136834;25374123;25502872;25813380;27397612;27452731;27726376;27832191;28035807;28764923;293688;293746;29391424;29427759;29557506;2956252;29567995;2963012;29671580;2971659;29741879;29789417;3004934;301546;30429286;30459171;30550790;31154438;31611695;31844290;31867016;32125861;32152943;32157095;32432721;32778820;32938616;33968037;34171305;34433824;34725484;35051231;35062233;35289036;35462789;35580925;35681461;36608640;37074911;37217939;3848661;40596516;4098172;6193777;6214588;6219696;6222381;6230668;6238120;631332;6334079;6439184;6454142;6607952;670886;6906228;702059;7391570;7499434;7500359;7505120;7522053;7525578;7527058;7534784;7541354;7541634;7542249;7542572;7542669;7559467;760802;761607;7685013;7690834;7691959;7693733;7852349;8002934;8118028;8344274;8345200;8440685;8495193;8560266;8609172;8786315;8798654;8838667;8900153;8910476;8943283;9030777;9038722;9115237;9251239;9252349;9294172;9341124;9346959;9443892;9565552;9685393;9725916;9733784;978134;9858236;9949188",
        "class_list": "glycogene",
        "function": "Complement Inhibitors Vitronectin and Clusterin Are Recruited from Human Serum to the Surface of Coronavirus OC43-Infected Lung Cells through Antibody-Dependent Mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of FBLN2 suppresses TGF-beta1-induced MRC-5 cell migration and fibrosis by downregulating VTN., [RefSeq, PubMed]; Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity., [UniProtKB]; The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein. [provided by RefSeq, Aug 2020]., [RefSeq]; Vitronectin and Its Interaction with PAI-1 Suggests a Functional Link to Vascular Changes in AMD Pathobiology. Publication Status: Online-Only, [RefSeq, PubMed]; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway., [UniProtKB]; Vitronectin, a Novel Urinary Proteomic Biomarker, Promotes Cell Pyroptosis in Juvenile Systemic Lupus Erythematosus. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 2,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 13,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 13,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 13,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 10,
        "reported_phosphosites": 13,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 615,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 169,
        "disease_count": 6,
        "glyco_site_count": 16,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7G0;P01141;Q9BSH7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0005044 scavenger receptor activity;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005796 Golgi lumen;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0061302 smooth muscle cell-matrix adhesion;GO:0006955 immune response;GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 44.5,
        "record_id": "P04004-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H0D6-1",
        "uniprot_id": "XRN2_HUMAN",
        "mass": 108582.0,
        "length": 950,
        "protein_name": "5'-3' exoribonuclease 2",
        "gene_name": "XRN2",
        "organism": "Human",
        "refseq_name": "5'-3' exoribonuclease 2 isoform 1",
        "refseq_ac": "NP_001304889",
        "gene_names_uniprotkb": "XRN2",
        "gene_names_refseq": "XRN2",
        "protein_names_uniprotkb": "5'-3' exoribonuclease 2; 3.1.13.-; DHM1-like protein; DHP protein",
        "protein_names_refseq": "5'-3' exoribonuclease 2 isoform 1; DHM1-like protein; DHP protein",
        "tax_id": 9606,
        "disease": "adenoid cystic carcinoma (Disease Ontology:DOID:0080202); lung cancer (Disease Ontology:DOID:1324); status epilepticus (Disease Ontology:DOID:1824); leiomyosarcoma (Disease Ontology:DOID:1967)",
        "pathway": " (hsa:22803);  (R-HSA-390471);  (R-HSA-6791226);  (R-HSA-9770562);  (R-HSA-9930044)",
        "pathway_count": 5,
        "publication_count": 214,
        "publication_id_list": "10.1101/2023.09.13.557529;10409438;10669729;11060040;11230166;11922599;12068309;12150911;12429849;12502735;14749727;15037765;15302935;15565158;16037817;16043514;16147866;16648491;16738141;16964243;17081983;17128255;17174896;17189298;17353269;17412707;17924679;18065403;18288197;18318008;18438418;18452278;18491316;18669648;18691976;18767875;18775504;19007248;19011634;19106111;19217410;19332556;19369195;19413330;19415658;19564402;19651622;19664995;19690332;19801658;20038530;20056613;20058876;20068230;20068231;20166139;20531386;20695905;20798176;20805244;20819938;21036871;21063389;21097556;21098288;21295486;21406692;21700224;21705430;21855801;21995946;22028470;22072790;22121020;22190735;22195017;22813749;22916032;23125361;23186163;23301498;23439679;23481700;23482395;23747015;23874216;2388630;24076191;24129315;24149845;24275569;24424021;24462208;24550520;24715725;24756126;25220460;25301780;25301781;25342745;25418920;25467444;25505266;25525153;25576301;25578728;25645385;25810538;25880248;25892735;25969445;26154972;26237581;26375851;26700805;26728557;26768311;26779609;26992070;27434818;27600516;27846572;27862975;27871484;27920218;28096519;28218747;28228285;28446606;28510447;28832583;28834231;28904123;28911096;29186539;29242379;29274231;29298432;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;29906447;30139799;30257008;30315122;30410026;30429286;30779550;31092671;31154438;31217245;31530632;31844290;31848261;31950173;31998317;32157095;32161166;32265295;32387766;32488085;32502341;32816001;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33592498;33691108;33717175;33767452;33912179;33913806;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34509645;34561969;34725712;34932366;35008409;35051231;35177536;35251023;35318648;35561310;35563787;35580925;36010968;36241641;36284347;36344846;37191774;37875486;37938771;38665916;39534244;40914422;9482744;9659921;9819444",
        "class_list": "",
        "function": "Co-transcriptional cleavage acts as a precursor to termination by presenting a free RNA 5' end that is recognized by the human 5' --> 3' exonuclease Xrn2, [RefSeq, PubMed]; Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224)., [UniProtKB, PubMed, PubMed, PubMed]; The exoribonuclease XRN2 mediates degradation of the long non-coding telomeric RNA TERRA., [RefSeq, PubMed]; The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer., [RefSeq, PubMed]; This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]., [RefSeq]; XRN2 Is Required for Cell Motility and Invasion in Glioblastomas. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 19,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 4,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3L8N4;Q6KGZ9;Q9BQL1;Q9NTW0;Q9NXS6;Q9UL53",
        "ec_number_list": "1.2.1.12;3.5.1.-;3.5.1.98;5.2.1.8;3.2.1.45;2.4.1.-;3.2.1.-;3.2.1.46;3.6.1.-;2.1.1.-;3.6.4.13;3.4.19.12;3.1.13.-;3.6.5.-;3.4.21.53",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004518 nuclease activity;GO:0001147 transcription termination site sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016020 membrane",
        "go_biological_process": "GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0007283 spermatogenesis;GO:0021766 hippocampus development;GO:0060041 retina development in camera-type eye",
        "synthesized_glycan_count": 0,
        "hit_score": 22.0,
        "record_id": "Q9H0D6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NSG2-1",
        "uniprot_id": "FIRRM_HUMAN",
        "mass": 96554.0,
        "length": 853,
        "protein_name": "FIGNL1-interacting regulator of recombination and mitosis",
        "gene_name": "FIRRM",
        "organism": "Human",
        "refseq_name": "FIGNL1-interacting regulator of recombination and mitosis isoform 1",
        "refseq_ac": "NP_001306976",
        "gene_names_uniprotkb": "FIRRM; APOLO1; C1orf112",
        "gene_names_refseq": "Apolo1; C1orf112; FIRRM; FLIP; MEICA1",
        "protein_names_uniprotkb": "FIGNL1-interacting regulator of recombination and mitosis; FIDGETIN-like-1 interacting protein; FLIP; POLO1-associating protein",
        "protein_names_refseq": "FIGNL1-interacting regulator of recombination and mitosis isoform 1; Fidgetin-like-1 interacting protein; POLO1-associating protein; associating protein with POLO1; uncharacterized protein C1orf112",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55732);  (R-HSA-2500257);  (R-HSA-5693568);  (R-HSA-912446)",
        "pathway_count": 4,
        "publication_count": 122,
        "publication_id_list": "10029069;10438626;10562567;10728666;10734115;10928988;11237011;11292842;11509732;12686547;12721304;14527420;14730319;15164066;15304223;15339662;15723797;15737063;16123081;16292313;16322221;16541025;16682347;17112726;17113138;17289582;17541404;17965729;17977839;17981954;18097444;18256600;18535008;18716626;19064610;19536175;19596236;19608861;19696148;19965387;20044539;20044541;20062530;20068231;20818382;20965415;21111234;21878504;21987589;22544926;22645308;22885700;23039964;23186163;23509288;23754376;24076221;24371268;24509834;24714562;24715725;24831703;25576301;26375851;26992070;27846572;28218747;28228285;28446606;28904123;29437277;29493099;29557506;29608566;30315122;30410026;30484775;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33633747;33691108;33717175;33912179;33936100;33968037;34087483;34171305;34211107;34260926;34405274;34509645;34932366;35051231;35251023;35580925;36010968;36241641;36284347;37256941;37347663;37515771;37556550;38286805;8929543;9008167;9311981;9450758;9649503;9781043;9826763",
        "class_list": "",
        "function": "FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress. Publication Status: Online-Only, [RefSeq, PubMed]; Forms a complex with FIGL1, which regulates DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:29608566, PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805). The FIGNL1-FIRRM complex is essential for resolution of homologous recombination intermediates in response to DNA interstrand cross-links (ICLs) (PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805). The complex regulates HR by promoting disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases (PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805). It also regulates HR during meiosis by promoting dissociation of DMC1 filaments from DNA (By similarity). Within the complex, provides the ATPase activity to disassemble DMC1 and RAD51 filaments, while FIRRM directly binds single-stranded DNA to facilitate this unloading (PubMed:37556550). Independently of FIRRM, slso acts as a regulator of PLK1 kinase activity at kinetochores that promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities (PubMed:34260926). Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis (PubMed:34260926)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Knockdown of C1orf112 by siRNA in HeLa cells significantly suppressed their growth. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NFP1;B3KU42;Q3KNQ1;Q9H8L5;Q9NVJ0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0051233 spindle midzone",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0036297 interstrand cross-link repair;GO:0045859 regulation of protein kinase activity;GO:0035825 homologous recombination",
        "synthesized_glycan_count": 0,
        "hit_score": 12.3,
        "record_id": "Q9NSG2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75155-1",
        "uniprot_id": "CAND2_HUMAN",
        "mass": 135256.0,
        "length": 1236,
        "protein_name": "Cullin-associated NEDD8-dissociated protein 2",
        "gene_name": "CAND2",
        "organism": "Human",
        "refseq_name": "cullin-associated NEDD8-dissociated protein 2 isoform 1",
        "refseq_ac": "NP_001155971",
        "gene_names_uniprotkb": "CAND2; KIAA0667; TIP120B",
        "gene_names_refseq": "CAND2; TIP120B; Tp120b",
        "protein_names_uniprotkb": "Cullin-associated NEDD8-dissociated protein 2; Cullin-associated and neddylation-dissociated protein 2; Epididymis tissue protein Li 169; TBP-interacting protein 120B; TBP-interacting protein of 120 kDa B; p120 CAND2",
        "protein_names_refseq": "TBP interacting protein; TBP-interacting protein 120B; TBP-interacting protein of 120 kDa B; cullin-associated NEDD8-dissociated protein 2 isoform 1; cullin-associated NEDD8-dissociated protein 2; cullin-associated and neddylation-dissociated protein 2; epididymis secretory sperm binding protein; epididymis tissue protein Li 169; p120 CAND2",
        "tax_id": 9606,
        "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:23066)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "11237011;12207886;12692129;19159115;20736409;23481700;24715725;26375851;26992070;27203392;28467828;29351928;29557506;29717274;30429286;31154438;31548259;31844290;31848261;32157095;32350084;32387766;32488085;32502341;32938616;32983136;33968037;34171305;34509645;34605609;35051231;36010968",
        "class_list": "",
        "function": "Based on these results it is unlikely CAND2 and WNT7a are the major genes that causes clubfoot. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Muscle-specific Cand2 is translationally upregulated by mTORC1 and promotes adverse cardiac remodeling., [RefSeq, PubMed]; NEURL rs12415501 and CAND2 rs4642101 are significantly associated with postoperative atrial fibrillation susceptibility after coronary artery bypass grafting among Chinese population, [RefSeq, PubMed]; Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes., [UniProtKB]; TIP120B is a specific substrate of KIAA10; both are highly expressed in human skeletal muscle, suggesting that KIAA10 may regulate TIP120B homeostasis specifically in this tissue., [RefSeq, PubMed]; TIP120B was induced in C2C12 myoblasts when these cells differentiated into myotubes (TIP120B)., [RefSeq, PubMed]; The work developed the tool and performed 'interaction analyses within chromatin regulatory circuitry' (IACRC); analysis found CAND2 may be a novel obesity susceptibility gene., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EGM9;E9KL24",
        "ec_number_list": "",
        "go_molecular_function": "GO:0017025 TBP-class protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0010265 SCF complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "O75155-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86UW7-1",
        "uniprot_id": "CAPS2_HUMAN",
        "mass": 147735.0,
        "length": 1296,
        "protein_name": "Calcium-dependent secretion activator 2",
        "gene_name": "CADPS2",
        "organism": "Human",
        "refseq_name": "calcium-dependent secretion activator 2 isoform b",
        "refseq_ac": "NP_001009571",
        "gene_names_uniprotkb": "CADPS2; CAPS2; KIAA1591",
        "gene_names_refseq": "CADPS2; CAPS2",
        "protein_names_uniprotkb": "Calcium-dependent secretion activator 2; CAPS-2; Calcium-dependent activator protein for secretion 2",
        "protein_names_refseq": "CAPS-2; Ca++-dependent secretion activator 2; Ca2+ dependent secretion activator 2; Ca2+-dependent activator protein for secretion 2; calcium-dependent activator protein for secretion 2; calcium-dependent secretion activator 2 isoform b",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)",
        "pathway": " (hsa:93664)",
        "pathway_count": 1,
        "publication_count": 41,
        "publication_id_list": "11237011;12659812;14530279;15857609;17380209;19008227;19664994;21406692;25645385;25892735;26375851;26992070;27600516;28647363;28834231;28971736;29557506;29769354;29786170;30078552;30779550;31154438;31844290;31848261;32157095;32488085;32928873;32938616;33580180;33592498;33936100;33981976;34087483;34185709;34932366;35051231;35318648;35580925;36284347;38538594;39894887",
        "class_list": "",
        "function": "CAPS proteins are involved in optimizing vesicular monoamine uptake and storage mediated by VMAT1 and VMAT2, [RefSeq, PubMed]; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity)., [UniProtKB]; Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic disturbance in CADPS2-mediated neurotrophin release contributes to autism susceptibility. GeneRIF: CADPS2-KO mice show autistic-like phenotypes. Moreover, the results show that some autistic patients have an aberrant splicing variant of CADPS2 mRNA, suggesting that a disturbance in CADPS2-mediated neurotrophin release contributes to autism. GeneRIF: Results from Cadps2-deficient mice and human data suggest that a disturbance in CADPS2-mediated neurotrophin release contributes to autistic-like cellular and behavioral phenotypes., [RefSeq, PubMed]; Identification, cloning, and comparative characterization of a second mammalian CAPS isoform, CAPS2; concluded that at the functional level, CAPS2 is largely redundant with CAPS1, [RefSeq, PubMed]; The top SNP rs2049161 involved gene DLGAP1 and the top gene CADPS2 in the gene-based analysis resulted in much literature evidence of associations with psychiatric disorders. Gene expression and network analysis showed their contribution to cognition function., [RefSeq, PubMed]; These results indicate that LRRK2 and alpha-synuclein participate in the dysregulation of CADPS2 by altering transcription and support the hypothesis that synaptic dysfunctions, through different mechanisms, might contribute to the neuronal defects of diseases such as Parkinson's disease., [RefSeq, PubMed]; This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
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        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
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        "secondary_ac_list": "A4D0X3;B7ZM56;Q658Q2;Q7Z5T7;Q8IZW9;Q8N7M4;Q9H6P4;Q9HCI1;Q9NWK8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005813 centrosome;GO:0005929 cilium;GO:0045211 postsynaptic membrane;GO:0030659 cytoplasmic vesicle membrane",
        "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis;GO:0016082 synaptic vesicle priming;GO:0045921 positive regulation of exocytosis;GO:1990504 dense core granule exocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "Q86UW7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y6J0-1",
        "uniprot_id": "CABIN_HUMAN",
        "mass": 246352.0,
        "length": 2220,
        "protein_name": "Calcineurin-binding protein cabin-1",
        "gene_name": "CABIN1",
        "organism": "Human",
        "refseq_name": "calcineurin-binding protein cabin-1 isoform a",
        "refseq_ac": "NP_001186210",
        "gene_names_uniprotkb": "CABIN1; KIAA0330",
        "gene_names_refseq": "CABIN1; CAIN; KB-318B8.7; PPP3IN",
        "protein_names_uniprotkb": "Calcineurin-binding protein cabin-1; CAIN; Calcineurin inhibitor",
        "protein_names_refseq": "calcineurin binding protein cabin 1; calcineurin inhibitor; calcineurin-binding protein cabin-1 isoform a",
        "tax_id": 9606,
        "disease": "ovarian carcinoma (Disease Ontology:DOID:4001)",
        "pathway": " (hsa:23523);  (R-HSA-2559584)",
        "pathway_count": 2,
        "publication_count": 100,
        "publication_id_list": "11237011;12700764;14718166;15621527;15655109;16901784;17158953;17242198;17242207;17525332;18452278;18477386;19029251;20068231;21406692;21807893;23186163;23303793;23481700;23964094;24714562;24715725;25418920;25505266;25576301;25645385;25880248;25892735;26154972;26375851;26811146;26992070;27600516;27846572;27920218;28063628;28218747;28228285;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29632711;29769354;29786170;30082790;30315122;30379171;30410026;30484775;30524438;30620550;30779550;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34509645;34561969;34932366;35051231;35318648;35561310;35580925;36010968;36241641;36284347;36581221;37938771;39894887;40596516;9655484",
        "class_list": "",
        "function": "Analysis of the trimeric HIRA, UBN1 and CABIN1 H3.3 histone chaperone complex Publication Status: Online-Only, [RefSeq, PubMed]; Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]., [RefSeq]; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of its target genes., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 19,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G5E9F3;Q6PHY0;Q9Y460",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0004864 protein phosphatase inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007166 cell surface receptor signaling pathway;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:1902275 regulation of chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "Q9Y6J0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15139-1",
        "uniprot_id": "KPCD1_HUMAN",
        "mass": 101704.0,
        "length": 912,
        "protein_name": "Serine/threonine-protein kinase D1",
        "gene_name": "PRKD1",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase D1 isoform 2",
        "refseq_ac": "NP_002733",
        "gene_names_uniprotkb": "PRKD1; PKD1; PKD; PRKCM",
        "gene_names_refseq": "CHDED; PKC-MU; PKCM; PKD1; PKD; PRKCM; PRKD1",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase D1; 2.7.11.13; Protein kinase C mu type; Protein kinase D; nPKC-D1; nPKC-mu",
        "protein_names_refseq": "nPKC-D1; nPKC-mu; protein kinase C mu type; protein kinase C, mu; serine/threonine-protein kinase D1 isoform 2; serine/threonine-protein kinase D1",
        "tax_id": 9606,
        "disease": "candidiasis (Disease Ontology:DOID:1508); congenital heart disease (Disease Ontology:DOID:1682); myocardial infarction (Disease Ontology:DOID:5844); congenital heart defects and ectodermal dysplasia (MONDO:MONDO:0044303)",
        "pathway": " (hsa:5587);  (R-HSA-1660661)",
        "pathway_count": 2,
        "publication_count": 130,
        "publication_id_list": "10197446;10473617;10523301;10722674;10751414;10764790;10802064;10867018;10947957;11237011;11741879;11937514;11978539;12407104;12505989;12637538;12893243;14685229;14685263;14976195;15024053;15063729;15226414;15328338;15337768;15471852;15701647;16100120;16118219;16571669;16793762;16891660;16895911;16959974;17023427;17050692;17322306;17331073;17344846;17355976;17442957;17449912;17591919;17703233;17804414;17982138;18076381;18165232;18165233;18184806;18239146;18332134;18509061;18669648;19005213;19029298;19135240;19211839;19233134;19369195;19413330;19416851;19506037;19655095;19664994;20061445;20110355;20182505;20444975;21209314;21292998;21357900;21406692;21620961;21644927;21726532;22517924;22970244;23180825;23602659;23754960;24569996;24623306;24782409;25576301;25788259;25889812;26304723;26992070;27479907;27846572;28575652;28703804;28834231;28904123;29266837;29557506;29563527;29652915;29786170;29789417;29933512;31154438;31289638;31406020;31844290;31895563;32082170;32157095;32488085;33141586;34357683;35104164;35409383;35580925;36284347;36899839;36902339;36907437;37224812;37390971;37611675;38104800;39128598;4339164;4817756;8119958;9188692;9312549;9363775",
        "class_list": "",
        "function": "IL-33 via PKCmu/PRKD1 Mediated alpha-Catenin Phosphorylation Regulates Endothelial Cell-Barrier Integrity and Ischemia-Induced Vascular Leakage. Publication Status: Online-Only, [RefSeq, PubMed]; Protein kinase D (PKD) on the crossroad of lipid absorption, synthesis and utilization. Review article, [RefSeq, PubMed]; Protein kinase D activity is a risk biomarker in prostate cancer that drives cell invasion by a Snail/ERK dependent mechanism., [RefSeq, PubMed]; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). Acts as a regulator of social behavior by mediating phosphorylation of OXTR, enhancing G(q)-dependent G protein-coupled receptor signaling (PubMed:35104164)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. [provided by RefSeq, Jan 2017]., [RefSeq]; The role of protein kinase D (PKD) in obesity: Lessons from the heart and other tissues. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 52,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NL64;B2RAF6",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:1904385 cellular response to angiotensin;GO:1990859 cellular response to endothelin;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0045806 negative regulation of endocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 13.1,
        "record_id": "Q15139-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95561-1",
        "uniprot_id": "CA105_HUMAN",
        "mass": 21209.0,
        "length": 183,
        "protein_name": "Uncharacterized protein C1orf105",
        "gene_name": "C1orf105",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C1orf105 isoform 1",
        "refseq_ac": "NP_640333",
        "gene_names_uniprotkb": "C1orf105",
        "gene_names_refseq": "C1orf105",
        "protein_names_uniprotkb": "Uncharacterized protein C1orf105",
        "protein_names_refseq": "uncharacterized protein C1orf105 isoform 1; uncharacterized protein C1orf105",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92346)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;31844290",
        "class_list": "",
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IY02",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "O95561-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96HA4-1",
        "uniprot_id": "CA159_HUMAN",
        "mass": 40283.0,
        "length": 380,
        "protein_name": "Uncharacterized protein C1orf159",
        "gene_name": "C1orf159",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C1orf159 isoform 1 precursor",
        "refseq_ac": "NP_001317235",
        "gene_names_uniprotkb": "C1orf159; PRO9739",
        "gene_names_refseq": "C1orf159",
        "protein_names_uniprotkb": "Uncharacterized protein C1orf159",
        "protein_names_refseq": "uncharacterized protein C1orf159 isoform 1 precursor; uncharacterized protein C1orf159",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54991)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12975309;24190977;28904123;31844290;34087483;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
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        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 0,
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        "missing_score": 9384,
        "biomarker_type": "",
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        "secondary_ac_list": "B3KQ46;Q5T2W6;Q6UX67;Q6ZR77;Q9NWV0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q96HA4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13619-1",
        "uniprot_id": "CUL4A_HUMAN",
        "mass": 87680.0,
        "length": 759,
        "protein_name": "Cullin-4A",
        "gene_name": "CUL4A",
        "organism": "Human",
        "refseq_name": "cullin-4A isoform 1",
        "refseq_ac": "NP_001008895",
        "gene_names_uniprotkb": "CUL4A",
        "gene_names_refseq": "CUL4A",
        "protein_names_uniprotkb": "Cullin-4A; CUL-4A",
        "protein_names_refseq": "CUL-4A; cullin-4A isoform 1",
        "tax_id": 9606,
        "disease": "Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); migraine without aura (Disease Ontology:DOID:12783); toxic shock syndrome (Disease Ontology:DOID:14115); neuroendocrine carcinoma (Disease Ontology:DOID:1800); breast carcinoma (Disease Ontology:DOID:3459); brain disease (Disease Ontology:DOID:936)",
        "pathway": " (hsa:8451);  (R-HSA-110314);  (R-HSA-5696394);  (R-HSA-5696395);  (R-HSA-5696400);  (R-HSA-6781823);  (R-HSA-6781827);  (R-HSA-6782135);  (R-HSA-6782210);  (R-HSA-8951664)",
        "pathway_count": 10,
        "publication_count": 330,
        "publication_id_list": "10230407;10391953;10526214;10535940;10597293;10734143;10811609;10878807;10944529;10973499;11007478;11069780;11141066;11237011;11259415;11278856;11279143;11292861;11292862;11454738;11511374;11585840;11733065;11904382;11961546;12080057;12101228;12186903;12208738;12226657;12504025;12504026;12526791;12538644;12609982;12660172;12682069;12732143;12759363;12815074;12816948;12944386;14517266;14578910;14609952;14690597;14739464;14742321;14757770;15220921;15282312;15361859;15367669;15448697;15537541;15548678;15572695;15574592;15590680;15601839;15652483;15688063;15694336;15799966;15811626;15811629;15882621;15916957;15964821;16030353;16171779;16223728;16246722;16401342;16473935;16482215;16491090;16531995;16537899;16547496;16647857;16678110;16707496;16751180;16790436;16943200;16949367;16964240;17000769;17041588;17079684;17081101;17132228;17183367;17220875;17254749;17290000;17332328;17466625;17466626;17497243;17720710;17785452;17882165;17948053;17981804;18079701;18093314;18206966;18212344;18342608;18614043;18669648;18691976;18775313;18776931;18805092;18826954;18851830;18926707;19056823;19109893;19250909;19279666;19321346;19413330;19609301;19617556;19651622;19661379;19713942;19748355;19940136;19941824;20068231;20129063;20166139;20190741;20227374;20368362;20541997;20855601;20876134;21070792;21135142;21282463;21388382;21447816;21463634;21778237;21863050;21940857;22081108;22118460;22306028;22466610;22466611;22466612;22466964;22537386;22902626;22935713;22959436;23000965;23038248;23045548;23186163;23201271;23319653;23333871;23352696;23401859;23453757;23478445;23481700;23535662;23535663;23563313;23583660;23751493;23906714;23912815;23973375;23986495;24076655;24127601;24209620;24275569;24366543;24366607;24402227;24636985;24714562;24715725;24768535;24793695;24793696;25154395;25314029;25349211;25355947;25418920;25435140;25531226;25538220;25576301;25645385;25892735;26042670;26151477;26154972;26344709;26375851;26431207;26460955;26632597;26711351;26728094;26906416;26992070;27030794;27222660;27565346;27846572;27920218;28115426;28218747;28228285;28510447;28832583;28834231;28904123;29153394;29242379;29351928;29393594;29437277;29493099;29508533;29557506;29632711;29769354;29779948;29786170;29789417;30166453;30315122;30410026;30484775;30524438;30610225;30833945;31154438;31217245;31530632;31844290;31848261;31937595;31998317;32005965;32157095;32161166;32265295;32284348;32350084;32355176;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33444648;33592498;33691108;33717175;33854232;33854239;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34561969;34725712;34932366;35051231;35154160;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37151881;37507642;38316879;38423594;38665916;40596516;40914422;7559382;7700386;8078911;8168482;8681378;8692841;8876179;9130708;9326587;9694792;9699634;9716411;9721878;9771713;9790970;9875289;9887101;9891082",
        "class_list": "",
        "function": "CUL4A Ubiquitin Ligase Is an Independent Predictor of Overall Survival in Pancreatic Adenocarcinoma., [RefSeq, PubMed]; CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]., [RefSeq]; CircSNTB2 and CUL4A Induces Dysfunction of Nucleus Pulposus Cells by Competitively Binding miR-665., [RefSeq, PubMed]; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins (PubMed:14578910, PubMed:14739464, PubMed:15448697, PubMed:15548678, PubMed:15811626, PubMed:16678110, PubMed:17041588, PubMed:24209620, PubMed:30166453, PubMed:33854232, PubMed:33854239). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:14739464, PubMed:15448697, PubMed:15548678, PubMed:15811626, PubMed:16678110, PubMed:17041588, PubMed:24209620). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (PubMed:14578910, PubMed:14739464, PubMed:15448697, PubMed:15548678, PubMed:15811626, PubMed:16678110, PubMed:17041588, PubMed:24209620). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component (PubMed:14578910, PubMed:14739464, PubMed:15448697, PubMed:15548678, PubMed:15811626, PubMed:16678110, PubMed:17041588, PubMed:24209620). DCX(DET1-COP1) directs ubiquitination of JUN (PubMed:14739464). DCX(DDB2) directs ubiquitination of XPC (PubMed:15811626). DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition (PubMed:16678110, PubMed:17041588, PubMed:24209620). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of p53/TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:14578910, PubMed:15448697, PubMed:15548678). DCX(DTL) directs autoubiquitination of DTL (PubMed:23478445). In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip (PubMed:16537899). Is involved in ubiquitination of HOXA9 (PubMed:14609952). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). The DCX(ERCC8) complex (also named CSA complex) plays a role in transcription-coupled repair (TCR) (PubMed:12732143, PubMed:32355176, PubMed:38316879). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). With CUL4B, contributes to ribosome biogenesis (PubMed:26711351)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Crystallographic analyses of the virally hijacked form of the human DDB1-CUL4A-ROC1 machinery, [RefSeq, PubMed]; S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 9,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A2W2;O75834;Q589T6;Q5TC62;Q6UP08;Q9UP17",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0160072 ubiquitin ligase complex scaffold activity",
        "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0080008 Cul4-RING E3 ubiquitin ligase complex",
        "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0001701 in utero embryonic development;GO:0007283 spermatogenesis;GO:0008283 cell population proliferation;GO:0010506 regulation of autophagy",
        "synthesized_glycan_count": 0,
        "hit_score": 33.3,
        "record_id": "Q13619-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6NYC1-1",
        "uniprot_id": "JMJD6_HUMAN",
        "mass": 46462.0,
        "length": 403,
        "protein_name": "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6",
        "gene_name": "JMJD6",
        "organism": "Human",
        "refseq_name": "bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 1",
        "refseq_ac": "NP_001074930",
        "gene_names_uniprotkb": "JMJD6; KIAA0585; PSR; PTDSR",
        "gene_names_refseq": "JMJD6; PSR; PTDSR1; PTDSR",
        "protein_names_uniprotkb": "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; 1.14.11.-; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR",
        "protein_names_refseq": "arginine demethylase and lysine hydroxylase; bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 1; bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; histone arginine demethylase JMJD6; jmjC domain-containing protein 6; jumonji domain-containing protein 6; peptide-lysine 5-dioxygenase JMJD6; phosphatidylserine receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23210);  (R-HSA-3214842);  (R-HSA-9629569)",
        "pathway_count": 3,
        "publication_count": 114,
        "publication_id_list": "11237011;11877474;1378441;14729065;15072554;15620353;15622002;15676025;16362057;16603237;16603238;16732292;16732293;16738407;17310255;17320163;17351631;17713478;17947579;18452278;1856229;19502796;19574390;19727073;19819225;19843542;20023638;20084082;20129925;20208542;20457893;20622853;20622854;20679243;20684070;21060799;21532585;21555454;22189873;22615488;22645359;22851697;23103944;23186163;23301498;23303181;24100311;24360279;24486019;24498420;24550447;24550462;24550463;25576301;25728928;26154972;26992070;27600516;27846572;27920218;28218747;28228285;28832583;28834231;28904123;29176719;29242379;29393594;29437277;29485866;29508533;29557506;29563586;29632046;29632711;29769354;29914368;29915238;30379171;30410026;30429286;30484775;30698747;30779550;31154438;31217245;31844290;32157095;32357974;32488085;32502341;32938616;32983136;33123756;33141586;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34171305;34211107;34229054;34932366;35051231;35561310;35580925;36010968;37188718;37567973;37880710;6688526",
        "class_list": "",
        "function": "Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873, PubMed:24498420). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24360279, PubMed:24498420). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis., [RefSeq, PubMed]; JMJD6 in tumor-associated macrophage regulates macrophage polarization and cancer progression via STAT3/IL-10 axis., [RefSeq, PubMed]; JMJD6-BRD4 complex stimulates lncRNA HOTAIR transcription by binding to the promoter region of HOTAIR and induces radioresistance in liver cancer stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KMN8;B4DGX1;Q86VY0;Q8IUM5;Q9Y4E2",
        "ec_number_list": "1.14.11.-",
        "go_molecular_function": "GO:0033746 histone H3R2 demethylase activity;GO:0033749 histone H4R3 demethylase activity;GO:0070815 peptidyl-lysine 5-dioxygenase activity;GO:0003723 RNA binding;GO:0005506 iron ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0018395 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "Q6NYC1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H7D7-1",
        "uniprot_id": "WDR26_HUMAN",
        "mass": 72124.0,
        "length": 661,
        "protein_name": "WD repeat-containing protein 26",
        "gene_name": "WDR26",
        "organism": "Human",
        "refseq_name": "WD repeat-containing protein 26 isoform b",
        "refseq_ac": "NP_001108585",
        "gene_names_uniprotkb": "WDR26; CDW2; MIP2; PRO0852",
        "gene_names_refseq": "CDW2; GID7; MIP2; SKDEAS; WDR26",
        "protein_names_uniprotkb": "WD repeat-containing protein 26; CUL4- and DDB1-associated WDR protein 2; Myocardial ischemic preconditioning up-regulated protein 2",
        "protein_names_refseq": "CUL4- and DDB1-associated WDR protein 2; GID complex subunit 7 homolog; WD repeat-containing protein 26 isoform b; myocardial ischemic preconditioning upregulated protein 2",
        "tax_id": 9606,
        "disease": "Skraban-Deardorff syndrome (MONDO:MONDO:0054636)",
        "pathway": " (hsa:80232);  (R-HSA-9861718)",
        "pathway_count": 2,
        "publication_count": 101,
        "publication_id_list": "11237011;15378603;17041588;17081983;18387606;18669648;18767875;19446606;19651622;19664995;20068231;20166139;21406692;22065575;22499340;23186163;23301498;23481700;23625927;24275569;24715725;25418920;25576301;25645385;25880248;26154972;26375851;26758079;26895380;26992070;27098453;27600516;27862975;27920218;28218747;28228285;28352266;28510447;28686853;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632711;29786170;29789417;29911972;30315122;30410026;30429286;30484775;30779550;30833945;31154438;31530632;31735643;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33462636;33592498;33633747;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34357683;34509645;34725712;35051231;35154160;35561310;35627197;36010968;36215666;36241641;36284347;37938771;38575527;38665916;38759627;40914422;7757881",
        "class_list": "",
        "function": "G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:26895380, PubMed:27098453). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Also protects cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism., [RefSeq, PubMed]; Skraban-Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly., [RefSeq, PubMed]; This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Two Novel Variants of WDR26 in Chinese Patients with Intellectual Disability. Publication Status: Online-Only, [RefSeq, PubMed]; WDR26 may act as a negative regulator in MAPK signaling pathway and play an important role in cell signal transduction., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0MNN3;Q4G100;Q59EC4;Q5GLZ9;Q86UY4;Q9H3C2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 10.4,
        "record_id": "Q9H7D7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z3I7-1",
        "uniprot_id": "ZN572_HUMAN",
        "mass": 61238.0,
        "length": 529,
        "protein_name": "Zinc finger protein 572",
        "gene_name": "ZNF572",
        "organism": "Human",
        "refseq_name": "zinc finger protein 572",
        "refseq_ac": "NP_689625",
        "gene_names_uniprotkb": "ZNF572",
        "gene_names_refseq": "ZNF572",
        "protein_names_uniprotkb": "Zinc finger protein 572",
        "protein_names_refseq": "zinc finger protein 572",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:137209)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "16959974;29242379;29557506;30379171;31154438;32157095",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4E9;A1L4F1;Q8N1Q0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q7Z3I7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14201-1",
        "uniprot_id": "BTG3_HUMAN",
        "mass": 29116.0,
        "length": 252,
        "protein_name": "Protein BTG3",
        "gene_name": "BTG3",
        "organism": "Human",
        "refseq_name": "protein BTG3 isoform a",
        "refseq_ac": "NP_001124386",
        "gene_names_uniprotkb": "BTG3; ANA; TOB5",
        "gene_names_refseq": "ANA/BTG3; ANA; APRO4; BTG3; TOB55; TOB5; TOFA",
        "protein_names_uniprotkb": "Protein BTG3; Abundant in neuroepithelium area protein; BTG family member 3; Protein Tob5",
        "protein_names_refseq": "B-cell translocation gene 3; BTG family member 3; abundant in neuroepithelium area protein; protein BTG3 isoform a; protein BTG3; protein Tob5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10950)",
        "pathway_count": 1,
        "publication_count": 42,
        "publication_id_list": "11237011;23481700;25418920;25576301;27920218;28218747;28832583;29242379;29393594;29557506;30315122;30379171;30410026;30429286;30779550;31217245;31530632;31844290;31848261;32157095;32265295;32502341;33051589;33311481;33592498;33936100;33968037;33981976;34171305;34211107;34405274;35045800;35051231;35362324;35580925;36010968;36241641;37938771;38253038;38714880;9067576;9632145",
        "class_list": "",
        "function": "A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis., [RefSeq, PubMed]; Correlation between BTG3, CASP9 and LRP4 single-nucleotide polymorphisms and susceptibility to papillary thyroid carcinoma., [RefSeq, PubMed]; Long non-coding RNA cancer susceptibility candidate 2 regulates the function of human fibroblast-like synoviocytes via the microRNA-18a-5p/B-cell translocation gene 3 signaling axis in rheumatoid arthritis., [RefSeq, PubMed]; Long noncoding RNA CA3-AS1 suppresses gastric cancer migration and invasion by sponging miR-93-5p and targeting BTG3., [RefSeq, PubMed]; Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase., [UniProtKB]; The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DSC4;Q53XV1;Q96ET7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045930 negative regulation of mitotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q14201-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P04798-1",
        "uniprot_id": "CP1A1_HUMAN",
        "mass": 58165.0,
        "length": 512,
        "protein_name": "Cytochrome P450 1A1",
        "gene_name": "CYP1A1",
        "organism": "Human",
        "refseq_name": "cytochrome P450 1A1 isoform 1",
        "refseq_ac": "NP_000490",
        "gene_names_uniprotkb": "CYP1A1",
        "gene_names_refseq": "AHH; CP11; CYP1A1; CYP1; CYPIA1; P1-450; P450-C; P450DX",
        "protein_names_uniprotkb": "Cytochrome P450 1A1; 1.14.14.1; 4.2.1.152; CYPIA1; Cytochrome P450 form 6; Cytochrome P450-C; Cytochrome P450-P1; Hydroperoxy icosatetraenoate dehydratase",
        "protein_names_refseq": "aryl hydrocarbon hydroxylase; cytochrome P1-450, dioxin-inducible; cytochrome P450 1A1 isoform 1; cytochrome P450 1A1; cytochrome P450 form 6; cytochrome P450, family 1, subfamily A, polypeptide 1; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; cytochrome P450-C; cytochrome P450-P1; flavoprotein-linked monooxygenase; hydroperoxy icosatetraenoate dehydratase; xenobiotic monooxygenase",
        "tax_id": 9606,
        "disease": "Keshan disease (Disease Ontology:DOID:0050083); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); polycystic ovary syndrome (Disease Ontology:DOID:11612); clubfoot (Disease Ontology:DOID:11836); head and neck cancer (Disease Ontology:DOID:11934); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Graves' disease (Disease Ontology:DOID:12361); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gallbladder cancer (Disease Ontology:DOID:3121); porphyria cutanea tarda (Disease Ontology:DOID:3132); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal cell carcinoma (Disease Ontology:DOID:4450); biliary tract cancer (Disease Ontology:DOID:4607); esophageal cancer (Disease Ontology:DOID:5041); fructose-1,6-bisphosphatase deficiency (Disease Ontology:DOID:5204); pneumonia (Disease Ontology:DOID:552); bronchitis (Disease Ontology:DOID:6132); reactive arthritis (Disease Ontology:DOID:6196); pulmonary hypertension (Disease Ontology:DOID:6432); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); chronic myeloid leukemia (Disease Ontology:DOID:8552); oral cavity cancer (Disease Ontology:DOID:8618); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:1543);  (R-HSA-1989781);  (R-HSA-211981);  (R-HSA-2142670);  (R-HSA-2142816);  (R-HSA-9018681)",
        "pathway_count": 6,
        "publication_count": 155,
        "publication_id_list": "10383923;10681376;10739168;10777541;11207026;11237011;11267664;11295847;11555828;11698341;12118000;12177166;12432928;12464245;12468260;12505311;12582161;12590139;12629583;12865317;14559847;14660610;15041462;15067378;15096040;15130092;15196988;15258110;15363546;15365656;15454734;15469410;15611369;15618738;15635043;15643613;15665333;15805301;15986113;16359177;16380219;16424216;16956909;16959974;16972786;17063266;17081983;1722803;17531965;17603290;17980933;18409146;18540824;18577768;18590468;18719978;18768509;18848529;19088433;19710929;19818771;19934321;19965576;20110263;2025243;20377136;20804547;20972997;21068195;21130723;21246002;21270613;21709011;21867913;22025136;22277800;22294106;22359202;22424782;22426923;22733497;22948778;22952673;23056546;23098461;23381648;23462525;23481700;23508959;23886208;23956430;24196956;24391993;24443269;24535777;24626963;24863943;24939416;24964616;25247845;25343551;25576301;25630554;25767599;26464823;26992070;27274286;27754415;27862975;28074113;28832583;29242379;29326607;29557506;29595663;2989797;3000715;3019683;31154438;31844290;31848261;32265295;32488085;32897882;32938616;33592498;33968037;34087483;35051231;37511239;38253038;38376298;3838385;39128373;39384367;6220203;7217086;7625847;7685352;7892212;7903454;8631948;8647822;8647857;8895751;8975785;9012850;9435160;9500998;9610791;9618440;9644715;9748239;9842986;9866708",
        "class_list": "",
        "function": "A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15041462, PubMed:15805301, PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15041462, PubMed:15805301, PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB]; Determination of SNP frequencies in the CYP1A1_CYP1A2 locus., [RefSeq, PubMed]; Genetic polymorphisms of CYP1A, CYP1B, CYP2C and risk of cervical cancer among rural population of Maharashtra: Findings from a hospital-based case-control study., [RefSeq, PubMed]; Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations. Publication Status: Online-Only, [RefSeq, PubMed]; Interaction between CYP1A1 gene polymorphism and environment factors on risk of endometrial cancer., [RefSeq, PubMed]; Polycyclic aromatic hydrocarbon and its adducts in peripheral blood: Gene and environment interaction among Chinese population., [RefSeq, PubMed]; This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 47,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4F3V9;A4F3W0;Q53G18",
        "ec_number_list": "1.14.14.1;4.2.1.152;1.14.13.n7;1.14.14.55;1.14.14.56;1.14.14.73;1.14.14.-;1.14.14.14;1.14.14.51;1.14.14.52;1.14.14.53;1.14.13.-;5.3.99.5;1.14.14.75;5.4.4.7;1.14.14.74;1.14.14.78;1.14.14.79;1.14.14.94;1.14.14.80;2.3.1.48;5.3.99.4;3.6.4.-;1.14.14.130;2.1.1.319;2.3.1.-;2.1.1.-;3.1.13.1;5.6.2.6;3.6.4.13",
        "go_molecular_function": "GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0019899 enzyme binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0002933 lipid hydroxylation;GO:0008210 estrogen metabolic process;GO:0042359 vitamin D metabolic process;GO:0046209 nitric oxide metabolic process;GO:0097267 omega-hydroxylase P450 pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 15.8,
        "record_id": "P04798-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BZR8-1",
        "uniprot_id": "B2L14_HUMAN",
        "mass": 36598.0,
        "length": 327,
        "protein_name": "Apoptosis facilitator Bcl-2-like protein 14",
        "gene_name": "BCL2L14",
        "organism": "Human",
        "refseq_name": "apoptosis facilitator Bcl-2-like protein 14 isoform 2",
        "refseq_ac": "NP_110393",
        "gene_names_uniprotkb": "BCL2L14; BCLG",
        "gene_names_refseq": "BCL2L14; BCLG",
        "protein_names_uniprotkb": "Apoptosis facilitator Bcl-2-like protein 14; Apoptosis regulator Bcl-G; Bcl2-L-14",
        "protein_names_refseq": "BCL2-like 14 (apoptosis facilitator); apoptosis facilitator Bcl-2-like protein 14 isoform 2; apoptosis facilitator Bcl-2-like protein 14; apoptosis regulator BCL-G; bcl2-L-14; testicular tissue protein Li 26",
        "tax_id": 9606,
        "disease": "prostate carcinoma (Disease Ontology:DOID:10286)",
        "pathway": " (hsa:79370);  (R-HSA-6803205)",
        "pathway_count": 2,
        "publication_count": 35,
        "publication_id_list": "10733530;11054413;11237011;11675392;11684014;11714700;11919562;1321151;14614825;14729977;15284860;15377670;15577913;15797384;15837622;15958553;16140933;16249378;17280616;17442733;18006276;18088087;18532927;19040420;19349281;19549844;23059823;23182941;23671130;24260043;32321829;34932366;39531497;39894887;7991565",
        "class_list": "",
        "function": "JAB1 is involved in the regulation of mitochondrial apoptotic pathway through specific interaction with BclGs., [RefSeq, PubMed]; Plays a role in apoptosis., [UniProtKB]; The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]., [RefSeq]; These data reveal adjacent gene rearrangements as a class of underexplored genetic aberrations that could be pathological in breast cancer, and identify BCL2L14-ETV6 as a recurrent gene fusion in more aggressive form of Triple-negative breast cancer tumor, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KAD0;Q96QR5;Q9BZR7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0012505 endomembrane system;GO:0043229 intracellular organelle",
        "go_biological_process": "GO:0006915 apoptotic process;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway;GO:0042981 regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "Q9BZR8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43852-1",
        "uniprot_id": "CALU_HUMAN",
        "mass": 37107.0,
        "length": 315,
        "protein_name": "Calumenin",
        "gene_name": "CALU",
        "organism": "Human",
        "refseq_name": "calumenin isoform b precursor",
        "refseq_ac": "NP_001124146",
        "gene_names_uniprotkb": "CALU",
        "gene_names_refseq": "CALU",
        "protein_names_uniprotkb": "Calumenin; Crocalbin; IEF SSP 9302",
        "protein_names_refseq": "IEF SSP 9302; calumenin isoform b precursor; crocalbin-like protein; multiple EF-hand protein",
        "tax_id": 9606,
        "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); proliferative diabetic retinopathy (Disease Ontology:DOID:13207)",
        "pathway": " (hsa:813);  (R-HSA-114608);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 4,
        "publication_count": 159,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10026136;10077652;10218588;10222138;10512690;10614670;10681634;10810289;10898936;10912521;10951195;10990447;11158056;11237011;11250653;11264294;11316783;11522292;11606061;11739083;11751371;11788658;12241545;12379487;12466191;12643545;12665801;12810533;12904166;1370451;1383255;1435334;14630798;15126567;15297306;15308688;15469690;15485880;15525596;15642270;16964243;17047378;17081065;17081983;17249697;17312271;17985932;18691976;18767875;19139490;19159218;19413330;20068231;23090970;23186163;23584533;23640497;24190977;24275569;2476804;2479552;25502872;25576301;25813380;26091039;26154972;27846572;27920218;28063628;28189267;28467828;28649982;28832583;28904123;29242379;29249144;29319298;29393594;29557506;29632046;29632711;29741879;29786170;29789417;30459171;30573663;30833945;31154438;31222486;31530632;31611695;31844290;31848261;32119511;32157095;32350084;32387766;32469983;32488085;32938616;33043033;33141586;33214551;33392160;33592498;33717175;33936100;33968037;34019948;34087483;34171305;34185709;34357683;34433824;34561969;34725712;35051231;35154160;35251023;35254053;35289036;35494241;35561310;35580925;36241641;36284347;37074911;37217939;37938771;38665916;38838015;40596516;6457647;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;8467233;8781553;8817670;8894645;8964575;9497324;9598325;9675259;9709957;9733769;9786878;9922210",
        "class_list": "",
        "function": "Establishment of a CALU, AURKA, and MCM2 gene panel for discrimination of metastasis from primary colon and lung cancers. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity)., [UniProtKB]; Replacing Leu with Gly (L150G) in Calu1 enables the protein to adopt a structural fold even in the Ca(2+) free form. The fourth (of seven) EF-hand of HsCalu1 nucleates the structural fold of the protein depending on the switch residue (Gly or Leu)., [RefSeq, PubMed]; The Calumenin modulates Sarco/Endoplasmic reticulumCa2+ATPase (SERCA) pump activity without drastically affecting ER-Ca(2+) concentration., [RefSeq, PubMed]; The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 11,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 11,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 11,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 114,
        "disease_count": 2,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KPG9;D6QS48;D6QS49;D6QS50;D6QS51;D6QS52;D6QS53;D6QS54;D6QS55;D6QS56;D6QS57;D6QS58;D6QS59;F5H1Q9;F5H879;O60456;Q6FHB9;Q96RL3;Q9NR43",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 28.6,
        "record_id": "O43852-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T1B0-1",
        "uniprot_id": "AXDN1_HUMAN",
        "mass": 118027.0,
        "length": 1012,
        "protein_name": "Axonemal dynein light chain domain-containing protein 1",
        "gene_name": "AXDND1",
        "organism": "Human",
        "refseq_name": "axonemal dynein light chain domain-containing protein 1",
        "refseq_ac": "NP_653297",
        "gene_names_uniprotkb": "AXDND1; C1orf125",
        "gene_names_refseq": "AXDND1; C1orf125",
        "protein_names_uniprotkb": "Axonemal dynein light chain domain-containing protein 1",
        "protein_names_refseq": "axonemal dynein light chain domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:126859)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "11237011;19413330;19536175;19664994;19913121;20628086;29557506;30379171;31429579;32350084;32357974;34759295;36215666;37217939;38997255;39894887",
        "class_list": "",
        "function": "AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans. Publication Status: Online-Only, [RefSeq, PubMed]; May be essential for spermiogenesis and male fertility probably by regulating the manchette dynamics, spermatid head shaping and sperm flagellum assembly., [UniProtKB, UniProtKB]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6AWB2;Q96LJ3;Q96M01",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:1905198 manchette assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q5T1B0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86VP6-1",
        "uniprot_id": "CAND1_HUMAN",
        "mass": 136376.0,
        "length": 1230,
        "protein_name": "Cullin-associated NEDD8-dissociated protein 1",
        "gene_name": "CAND1",
        "organism": "Human",
        "refseq_name": "cullin-associated NEDD8-dissociated protein 1 isoform 1",
        "refseq_ac": "NP_060918",
        "gene_names_uniprotkb": "CAND1; KIAA0829; TIP120A; TIP120",
        "gene_names_refseq": "CAND1; TIP120A; TIP120",
        "protein_names_uniprotkb": "Cullin-associated NEDD8-dissociated protein 1; Cullin-associated and neddylation-dissociated protein 1; TBP-interacting protein 120A; TBP-interacting protein of 120 kDa A; p120 CAND1",
        "protein_names_refseq": "TBP-interacting protein of 120 kDa A; cullin-associated NEDD8-dissociated protein 1 isoform 1; cullin-associated NEDD8-dissociated protein 1; p120 CAND1",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:55832);  (R-HSA-6798695);  (R-HSA-8951664);  (R-HSA-917937)",
        "pathway_count": 4,
        "publication_count": 239,
        "publication_id_list": "10535940;10597293;10811609;10878807;10931946;10973499;11069780;11230166;11237011;11259415;11292861;11292862;11323407;11454738;11585840;11733065;11961546;12101228;12186903;12453412;12504025;12504026;12526791;12538644;12609982;12682069;12759363;12816948;12958161;14576842;14690597;14757770;15001581;15044468;15201052;15282312;15361859;15367669;15531878;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16143108;16171779;16274220;16377569;16401342;16407072;16408927;16449638;16510471;16547496;16647857;16707496;16790436;16943200;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18194661;18206966;18452278;18669648;18691976;18775313;18776931;18805092;18826954;18851830;18926707;19250909;19321346;1946430;19608861;19617556;19651622;19748355;19762596;19762597;20058876;20068230;20068231;20550936;20820187;21249194;21447816;21463634;2154449;21778237;21863050;21940857;22118460;22223895;22306028;22466964;22537386;22959436;23186163;23201271;23301498;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23615448;23650620;23912815;23986495;24076655;24192928;24366543;24366607;24636985;24714562;24715725;24793695;24793696;25314029;25349211;25355947;25418920;25531226;25548167;25576301;25645385;25810538;25880248;26030138;26154972;26344709;26460955;26632597;26728094;26768311;26811146;26906416;26929215;26992070;27030794;27222660;27565346;27846572;27862975;28115426;28510447;28904123;29153394;29317506;29393594;29437277;29493099;29557506;30315122;30397120;30410026;30429286;30484775;30573663;30610225;30833945;31092671;31154438;31217245;31222486;31530632;31717259;31844290;31848261;31998317;32005965;32119511;32157095;32161166;32265295;32284348;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33214551;33298915;33444648;33465208;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34357683;34433824;34725712;34932366;35008409;35051231;35083852;35138101;35154160;35318648;35580925;36010968;36241641;36284347;37938771;38148115;38665916;40596516;40914422;7983023;8041788;8692836;8695634;9790970;9887101;9891082",
        "class_list": "",
        "function": "ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3. Erratum:[J Immunother Cancer. 2024 Jul 10;12(7):e007766corr1. doi: 10.1136/jitc-2023-007766corr1. PMID: 38986545] Publication Status: Online-Only, [RefSeq, PubMed]; Binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex, [RefSeq, PubMed]; CAND1 does not function by sequestering cullins in vivo to prevent substrate receptor autoubiquitination and is likely to regulate cullin RING ligase activity via alternative mechanisms Publication Status: Online-Only, [RefSeq, PubMed]; COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding., [RefSeq, PubMed]; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation, [RefSeq, PubMed]; Study shows that Cand1 can unambiguously stimulate SCF activity in vitro by enabling an F box protein-Skp1 complex to access Cul1 that was previously occupied by a different F box protein-Skp1 complex, and that Cand1 promotes assembly in vivo of new F box proteins with pre-existing Cul1 molecules., [RefSeq, PubMed]; This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
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        "secondary_ac_list": "B2RAU3;O94918;Q6PIY4;Q8NDJ4;Q96JZ9;Q96T19;Q9BTC4;Q9H0G2;Q9P0H7;Q9UF85",
        "ec_number_list": "",
        "go_molecular_function": "GO:0017025 TBP-class protein binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0030154 cell differentiation;GO:0043086 negative regulation of catalytic activity;GO:0016567 protein ubiquitination;GO:0010265 SCF complex assembly;GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 24.2,
        "record_id": "Q86VP6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0C862-1",
        "uniprot_id": "C1T9A_HUMAN",
        "mass": 34681.0,
        "length": 333,
        "protein_name": "Complement C1q and tumor necrosis factor-related protein 9A",
        "gene_name": "C1QTNF9",
        "organism": "Human",
        "refseq_name": "complement C1q and tumor necrosis factor-related protein 9A precursor",
        "refseq_ac": "NP_001290066",
        "gene_names_uniprotkb": "C1QTNF9; C1QTNF9A; PRO21380",
        "gene_names_refseq": "AQL1; C1QTNF9A; C1QTNF9; CTRP9",
        "protein_names_uniprotkb": "Complement C1q and tumor necrosis factor-related protein 9A; Complement C1q and tumor necrosis factor-related protein 9",
        "protein_names_refseq": "C1q and tumor necrosis factor related protein 9; complement C1q and tumor necrosis factor-related protein 9A precursor; complement C1q and tumor necrosis factor-related protein 9A; complement C1q and tumor necrosis factor-related protein 9; complement C1q tumor necrosis factor-related protein 9A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:338872)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "12975309;19666007;24357853;25105737;27862975;36996742;37029975;37774521;38567599",
        "class_list": "",
        "function": "Association Between Circulating Levels of C1q/TNF-Related Protein-9 and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis., [RefSeq, PubMed]; C1q/tumor necrosis factor-related protein-9 exerts antioxidant and anti-inflammatory effects on oxygen-glucose deprivation/reoxygenation-stimulated neurons by modulating the Akt-GSK-3beta-Nrf2 cascade via AdipoR1., [RefSeq, PubMed]; CTRP9 alleviates hypoxia/reoxygenation-induced human placental vascular endothelial cells impairment and mitochondrial dysfunction through activating AMPK/Nrf2 signaling., [RefSeq, PubMed]; Causal association between complement system FHR-5, CTRP9, and breast carcinoma in situ: a Mendelian randomization study., [RefSeq, PubMed]; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways., [UniProtKB, UniProtKB]; Serum CTRP9 concentration was significantly and positively associated with arterial stiffness in patients with type 2 diabetes, [RefSeq, PubMed]; Serum CTRP9 concentrations were positively associated with favorable glucose or metabolic phenotypes and absence of metabolic syndrome, independent of serum total adiponectin concentrations., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A3T6;Q0VGC5;Q5VX65;Q5VX66;Q8IUU4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005179 hormone activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "P0C862-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99643-1",
        "uniprot_id": "C560_HUMAN",
        "mass": 18610.0,
        "length": 169,
        "protein_name": "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial",
        "gene_name": "SDHC",
        "organism": "Human",
        "refseq_name": "succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 2 precursor",
        "refseq_ac": "NP_001030588",
        "gene_names_uniprotkb": "SDHC; CYB560; SDH3",
        "gene_names_refseq": "CYB560; CYBL; PGL3; PPGL3; QPS1; SDH3; SDHC",
        "protein_names_uniprotkb": "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; CYBL; Integral membrane protein CII-3; Malate dehydrogenase [quinone] cytochrome b560 subunit; QPs-1; QPs1; Succinate dehydrogenase complex subunit C; Succinate-ubiquinone oxidoreductase cytochrome B large subunit",
        "protein_names_refseq": "cytochrome B large subunit of complex II; integral membrane protein CII-3b; large subunit of cytochrome b; malate dehydrogenase [quinone] cytochrome b560 subunit; succinate dehydrgenase cytochrome b; succinate dehydrogenase 3, integral membrane subunit; succinate dehydrogenase complex subunit C integral membrane protein 15kDa; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kD; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 2 precursor; succinate dehydrogenase cytochrome b560 subunit, mitochondrial; succinate-ubiquinone oxidoreductase cytochrome B large subunit",
        "tax_id": 9606,
        "disease": "paraganglioma (Disease Ontology:DOID:0050773); pheochromocytoma/paraganglioma syndrome 3 (Disease Ontology:DOID:0061218); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); Leigh disease (Disease Ontology:DOID:3652); lung non-small cell carcinoma (Disease Ontology:DOID:3908); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)",
        "pathway": " (hsa:6391);  (R-HSA-611105);  (R-HSA-71403);  (R-HSA-9854311)",
        "pathway_count": 4,
        "publication_count": 124,
        "publication_id_list": "10327278;1052766;10673423;10727444;11062460;11237011;11278619;11695836;12207025;12231006;12837546;13181903;1327877;14249115;14555658;14741580;14832224;14946179;15234968;15247478;15250827;15652751;15877282;15987702;16143825;16230336;16737955;16740313;17033964;17182618;17432878;17668387;17804857;17923681;186667;18806796;18914071;1946331;19628817;2005110;20167786;20435888;20847235;22416140;22645359;23150584;23270816;23564345;23747254;239860;24954416;24954417;25564869;25576301;25880248;26024233;26749241;26992070;27189937;27374498;28218747;28228285;28380382;28391595;28887308;28904123;29393594;29437277;29493099;29557506;29769354;29786170;30315122;30410026;30429286;30761759;30844107;31154438;31217245;31222486;31844290;32157095;32265295;32357974;32387766;32897882;32938616;32983136;33058874;33141586;33392160;33537174;33624983;33633747;33717175;33968037;34171305;34289383;34357683;34509645;34932366;35051231;35366151;35580925;36010968;36139014;36241641;36420423;36581221;37098072;37938771;4288886;8200987;8616157;9533030;9714607;9765290;9765291;9792106;9792662;9809442;9851882;9878551;9989622",
        "class_list": "",
        "function": "Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:9533030). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SDHC Methylation Pattern in Patients With Carney Triad., [RefSeq, PubMed]; This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75609;Q3C259;Q3C2D8;Q3C2H4;Q5VTH3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0008177 succinate dehydrogenase (quinone) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0016020 membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase)",
        "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration;GO:0006121 mitochondrial electron transport, succinate to ubiquinone",
        "synthesized_glycan_count": 0,
        "hit_score": 12.5,
        "record_id": "Q99643-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P17655-1",
        "uniprot_id": "CAN2_HUMAN",
        "mass": 79995.0,
        "length": 700,
        "protein_name": "Calpain-2 catalytic subunit",
        "gene_name": "CAPN2",
        "organism": "Human",
        "refseq_name": "calpain-2 catalytic subunit isoform 2",
        "refseq_ac": "NP_001139540",
        "gene_names_uniprotkb": "CAPN2; CANPL2",
        "gene_names_refseq": "CANP2; CANPL2; CANPml; CAPN2; mCANP",
        "protein_names_uniprotkb": "Calpain-2 catalytic subunit; 3.4.22.53; CANP 2; Calcium-activated neutral proteinase 2; Calpain M-type; Calpain large polypeptide L2; Calpain-2 large subunit; M-calpain; Millimolar-calpain",
        "protein_names_refseq": "CANP 2; M-calpain; calcium-activated neutral proteinase 2; calpain 2, (m/II) large subunit; calpain 2, large [catalytic] subunit; calpain 2, large subunit; calpain M-type; calpain, large polypeptide L2; calpain-2 catalytic subunit isoform 2; calpain-2 catalytic subunit; millimolar-calpain",
        "tax_id": 9606,
        "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:824);  (R-HSA-1474228);  (R-HSA-8862803);  (R-HSA-9856530);  (R-HSA-9860927)",
        "pathway_count": 5,
        "publication_count": 146,
        "publication_id_list": "10229672;10376603;10386589;10604467;10639123;10649434;10706100;10764742;10809722;10830966;10944468;10986281;11237011;11375993;11853546;11872628;11909964;11968001;12176338;12665801;12724311;12727852;12843408;14973287;14993287;15234972;15304325;15590058;15591058;15718470;15958533;16133547;1649600;16631740;16780920;16825321;1698775;1707285;17129378;17332331;17354228;17608959;17650508;18280240;18434311;18658137;18691386;18710921;19010778;19020623;19571574;19657146;19714641;19723632;20142769;21030783;21297635;21441952;21670566;21784848;21864727;22159414;22899714;23035980;23301498;23845380;24715725;2539381;25418920;25576301;25645385;26248159;26768311;26853435;27452731;27566546;27655845;27797339;27846572;27862975;27920218;28235949;28510447;28514659;2852952;28832583;29242379;29331515;29393594;29493099;29557506;29786170;30429286;31205027;31217245;31408443;31844290;32037480;32157095;32265295;32296767;32350084;32357974;32387766;32488085;32673515;32938616;32983136;33592498;33968037;33981976;34019948;34171305;34185709;34381117;34405274;34499618;34725712;35051231;35251023;35318648;35580925;35697802;36010968;36215666;36241641;36284347;36964131;37663545;38665916;38844946;40914422;7075587;7547873;7698360;7876172;8226919;8626565;8700127;9065415;9115292;9148753;9228946;9461298;9620797;9852107",
        "class_list": "",
        "function": "CAPN2 promotes apalutamide resistance in metastatic hormone-sensitive prostate cancer by activating protective autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity)., [UniProtKB, UniProtKB, PubMed]; Cleavage and activation of LIM kinase 1 as a novel mechanism for calpain 2-mediated regulation of nuclear dynamics. Publication Status: Online-Only, [RefSeq, PubMed]; Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 9,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NDG7;B7ZA96;E7ES58;Q16738;Q6PJT3;Q8WU26;Q9HBB1",
        "ec_number_list": "3.4.22.53;3.4.22.-;3.4.22.52;3.4.22.54",
        "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0019899 enzyme binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding;GO:0008092 cytoskeletal protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol",
        "go_biological_process": "GO:0006508 proteolysis;GO:0001666 response to hypoxia;GO:0042542 response to hydrogen peroxide;GO:0071222 cellular response to lipopolysaccharide;GO:0007565 female pregnancy",
        "synthesized_glycan_count": 0,
        "hit_score": 14.9,
        "record_id": "P17655-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P21579-1",
        "uniprot_id": "SYT1_HUMAN",
        "mass": 47573.0,
        "length": 422,
        "protein_name": "Synaptotagmin-1",
        "gene_name": "SYT1",
        "organism": "Human",
        "refseq_name": "synaptotagmin-1 isoform 1",
        "refseq_ac": "NP_001129277",
        "gene_names_uniprotkb": "SYT1; SVP65; SYT",
        "gene_names_refseq": "BAGOS; P65; SVP65; SYT1; SYT",
        "protein_names_uniprotkb": "Synaptotagmin-1; Synaptotagmin I; SytI; p65",
        "protein_names_refseq": "synaptotagmin I; synaptotagmin-1 isoform 1; sytI",
        "tax_id": 9606,
        "disease": "congenital myasthenic syndrome 7 (Disease Ontology:DOID:0110659); congenital myasthenic syndrome (Disease Ontology:DOID:3635); neuromuscular junction disease (Disease Ontology:DOID:439); infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome (MONDO:MONDO:0033864)",
        "pathway": " (hsa:6857);  (R-HSA-181429);  (R-HSA-181430);  (R-HSA-210500);  (R-HSA-212676);  (R-HSA-264642);  (R-HSA-5250958);  (R-HSA-5250989);  (R-HSA-6794361);  (R-HSA-8856825);  (R-HSA-8856828);  (R-HSA-888590)",
        "pathway_count": 12,
        "publication_count": 285,
        "publication_id_list": "10.1101/2023.09.13.557529;10097102;10436022;10440375;10535736;10542231;10559856;10559861;10559924;10567358;10613896;10620514;10625686;10766823;10769163;10932256;10983987;11001057;11015561;11017172;11027560;11068039;11071885;11076969;11082044;11231140;11237011;11239472;11242046;11247302;11381094;11454741;11470803;11516654;11517213;11532990;11577110;11588219;11604393;11756489;11877457;11877461;11889126;11919637;11927540;11988742;12057195;12086608;12213833;12221107;12234931;12429842;12447393;12451172;12459720;12464600;12519779;12717448;12750892;12847086;12944396;12952949;12958364;1317852;1331807;1339386;14504267;14555962;14581451;14617351;14622578;14622579;14662753;14726597;15134832;15217342;15252009;15260957;15318165;15339664;1535555;15473838;15502812;15502813;15540461;15649145;15671180;15703209;15728179;15802264;15895077;15916959;15935055;16103228;16116111;16159959;16215232;16242404;16326391;16410077;16459302;16460808;16516836;16616430;16624946;16707488;16722236;16723738;16798879;16846852;16880396;16903783;17018281;17035995;17158794;17267500;17301226;17360967;17456551;17478680;17494869;17512409;17522231;17540576;17609109;17681954;17713526;17762867;17765681;17766642;17891149;17897391;17978091;17989281;18032517;18093523;18166656;18199683;18215623;18388313;1840599;1847920;18510355;18617632;18775314;18790740;18812509;18819912;18829961;18981233;19092055;19140243;19234194;19287005;19296720;19375301;19458185;19536138;19575674;19603039;19664994;1968060;19696796;19696798;19713939;19732400;19776351;19809571;19853559;20033059;20059951;20064387;20064388;20211604;20231386;20233039;20351096;20428113;20448150;20519524;20826345;20946875;21102408;2115402;21187331;21278753;21282647;21316588;21406692;21445324;21482805;21499258;21613550;21779028;21841790;21883765;21925111;21927000;21927001;21962517;21995445;22099461;22118466;22233676;22357968;22454523;22484487;22505844;2257624;22720883;22815487;22863004;22942912;23297414;23363473;23536704;23647335;23823722;23861397;23891661;23999003;24130457;24186068;24384571;24578174;24581490;24680432;24746795;24789820;24966051;25107275;25303366;25341920;25378172;25705886;25712080;26042225;26403691;26829388;2890644;2892215;30107533;3214421;3417785;36044553;37150983;37938771;38758649;6146630;7527117;7569928;7695896;7736595;7803399;7822302;7823026;7877694;7910017;8051110;8071310;8095030;8211186;8402889;8524399;8552632;8553074;8576240;8837779;9069287;9092476;9100026;9169477;9260930;9303539;9427626;9428629;9635431;9701566;9712688;9723620;9736607;9753324;9808458;9812899;9927700",
        "class_list": "",
        "function": "Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003)., [UniProtKB, UniProtKB, PubMed]; Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B(+) vesicle pathway in liver cancer., [RefSeq, PubMed]; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiRNA-363-3p Hinders Proliferation, Migration, Invasion and Autophagy of Thyroid Cancer Cells by Controlling SYT1 Transcription to affect NF-kappaB., [RefSeq, PubMed]; Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1., [RefSeq, PubMed]; This gene encodes a member of the synaptotagmin protein family. The synaptotagmins are integral membrane proteins of synaptic vesicles that serve as calcium sensors in the process of vesicular trafficking and exocytosis. The encoded protein participates in triggering neurotransmitter release at the synapse in response to calcium binding. Mutations in this gene are associated with Baker-Gordon syndrome. [provided by RefSeq, Jan 2023]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6AI31",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0060201 clathrin-sculpted acetylcholine transport vesicle membrane;GO:0060203 clathrin-sculpted glutamate transport vesicle membrane;GO:0070083 clathrin-sculpted monoamine transport vesicle membrane;GO:0005737 cytoplasm",
        "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030100 regulation of endocytosis;GO:0030154 cell differentiation;GO:0051291 protein heterooligomerization;GO:0007268 chemical synaptic transmission",
        "synthesized_glycan_count": 0,
        "hit_score": 28.8,
        "record_id": "P21579-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96NH3-1",
        "uniprot_id": "BROMI_HUMAN",
        "mass": 144756.0,
        "length": 1257,
        "protein_name": "Protein broad-minded",
        "gene_name": "TBC1D32",
        "organism": "Human",
        "refseq_name": "protein broad-minded isoform 1",
        "refseq_ac": "NP_689943",
        "gene_names_uniprotkb": "TBC1D32; BROMI; C6orf170; C6orf171",
        "gene_names_refseq": "ALHSA; BROMI; C6orf170; C6orf171; OFD9; RP100; TBC1D32",
        "protein_names_uniprotkb": "Protein broad-minded; TBC1 domain family member 32",
        "protein_names_refseq": "broad-minded homolog; protein broad-minded isoform 1; protein broad-minded",
        "tax_id": 9606,
        "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Meckel syndrome (Disease Ontology:DOID:0050778); orofaciodigital syndrome IX (Disease Ontology:DOID:0060382); retinitis pigmentosa 100 (Disease Ontology:DOID:0061298); VACTERL association (Disease Ontology:DOID:14679); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); Alsahan-Harris syndrome (MONDO:MONDO:0979871)",
        "pathway": " (hsa:221322)",
        "pathway_count": 1,
        "publication_count": 36,
        "publication_id_list": "11237011;20159594;24190977;24285566;25880248;26154972;26992070;29437277;30410026;30429286;30484775;30905400;31130284;31844290;32060556;32157095;32357974;32387766;32573025;32897882;32983136;33141586;33298915;33592498;33912179;33968037;33981976;34509645;35051231;35494241;35609210;36010968;36826837;37217939;37768732;40319332",
        "class_list": "",
        "function": "BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1., [RefSeq, PubMed]; Confirming TBC1D32-related ciliopathy in humans., [RefSeq, PubMed]; Loss-of-Function Variants in TBC1D32 Underlie Syndromic Hypopituitarism., [RefSeq, PubMed]; Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity)., [UniProtKB, UniProtKB]; Studies in mouse and zebrafish implicate that TBC1D32 is involved in sonic hedgehog signaling., [RefSeq, PubMed]; Study identified 2 cases with a severe ciliopathy phenotype consistent with oro-facio-digital syndrome type IX; the autozygome of each index harbored a single truncating variant and the affected genes (SCLT1 and TBC1D32/C6orf170) have roles in centrosomal biology and ciliogenesis; findings suggest a role of SCLT1 and TBC1D32 in ciliopathy pathogenesis, [RefSeq, PubMed]; TBC1D32 variants disrupt retinal ciliogenesis and cause retinitis pigmentosa. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a TBC-domain containing protein. Studies of a similar protein in mouse and zebrafish suggest that the encoded protein is involved in sonic hedgehog signaling, and that it interacts with and stabilizes cell cycle-related kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5SZD6;Q5SZM6;Q6ZMY4;Q6ZUR7;Q8NB47",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium",
        "go_biological_process": "GO:1905515 non-motile cilium assembly;GO:0003406 retinal pigment epithelium development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q96NH3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H6S1-1",
        "uniprot_id": "AZI2_HUMAN",
        "mass": 44935.0,
        "length": 392,
        "protein_name": "5-azacytidine-induced protein 2",
        "gene_name": "AZI2",
        "organism": "Human",
        "refseq_name": "5-azacytidine-induced protein 2 isoform b",
        "refseq_ac": "NP_001127904",
        "gene_names_uniprotkb": "AZI2; NAP1; TBKBP2",
        "gene_names_refseq": "AZ2; AZI2; NAP1; TILP",
        "protein_names_uniprotkb": "5-azacytidine-induced protein 2; NF-kappa-B-activating kinase-associated protein 1; Nak-associated protein 1; Nap1; TILP",
        "protein_names_refseq": "5-azacytidine induced gene 2; 5-azacytidine-induced protein 2 isoform b; 5-azacytidine-induced protein 2; NAK-associated protein 1; NF-kappa-B-activating kinase-associated protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64343)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "11237011;14560022;15611223;17142768;17568778;18691976;19369195;21931555;21931631;23186163;28832583;29242379;29393594;29786170;30429286;30459273;32157095;32350084;32938616;33912179;33981976;34357683;35051231;35154160;37733921;38059900;39276928",
        "class_list": "",
        "function": "AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer., [RefSeq, PubMed]; AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]., [RefSeq]; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223)., [UniProtKB, PubMed, PubMed, PubMed]; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1., [UniProtKB, UniProtKB]; Both the cytoplasmic and TLR3-mediated dsRNA recognition pathways converge upon NAP1 for the activation of the IRF-3 and IFN-beta promoter., [RefSeq, PubMed]; NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis., [RefSeq, PubMed]; TBK1 adaptor AZI2/NAP1 regulates NDP52-driven mitochondrial autophagy., [RefSeq, PubMed]; These results define NAK-associated protein 1 (NAP1) as an activator of IkappaB kinase-related kinases and suggest that the NAK-NAP1 complex may protect cells from TNF-alpha-induced apoptosis by promoting NF-kappaB activation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3M2;C9JB40;H7BXU6;Q86W99;Q9BQF1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0043124 negative regulation of canonical NF-kappaB signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q9H6S1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BXJ2-1",
        "uniprot_id": "C1QT7_HUMAN",
        "mass": 30683.0,
        "length": 289,
        "protein_name": "Complement C1q tumor necrosis factor-related protein 7",
        "gene_name": "C1QTNF7",
        "organism": "Human",
        "refseq_name": "complement C1q tumor necrosis factor-related protein 7 isoform a precursor",
        "refseq_ac": "NP_001128642",
        "gene_names_uniprotkb": "C1QTNF7; CTRP7",
        "gene_names_refseq": "C1QTNF7; CTRP7; ZACRP7",
        "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 7",
        "protein_names_refseq": "C1q and tumor necrosis factor related protein 7; complement C1q tumor necrosis factor-related protein 7 isoform a precursor; complement C1q tumor necrosis factor-related protein 7; complement-c1q tumor necrosis factor-related protein 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:114905)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;19344414;20585324;31965030;33912179",
        "class_list": "",
        "function": "Found four markers that meet the criteria for genome-wide significance (P<5x10-8) with the CD symptom count, two of which are located in the gene C1QTNF7 (C1q and tumor necrosis factor-related protein 7). GeneRIF: Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Implications of C1q/TNF-related protein superfamily in patients with coronary artery disease. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
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        "reported_mutagensis": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBT3;J3KPW3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q9BXJ2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P09496-1",
        "uniprot_id": "CLCA_HUMAN",
        "mass": 27077.0,
        "length": 248,
        "protein_name": "Clathrin light chain A",
        "gene_name": "CLTA",
        "organism": "Human",
        "refseq_name": "clathrin light chain A isoform c",
        "refseq_ac": "NP_001070145",
        "gene_names_uniprotkb": "CLTA",
        "gene_names_refseq": "CLTA; LCA",
        "protein_names_uniprotkb": "Clathrin light chain A; Lca",
        "protein_names_refseq": "clathrin light chain A isoform c; clathrin, light polypeptide (Lca)",
        "tax_id": 9606,
        "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); peritonitis (Disease Ontology:DOID:8283); liver benign neoplasm (Disease Ontology:DOID:916); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hereditary fructose intolerance syndrome (Disease Ontology:DOID:9869)",
        "pathway": " (hsa:1211);  (R-HSA-168275);  (R-HSA-177504);  (R-HSA-190873);  (R-HSA-196025);  (R-HSA-2132295);  (R-HSA-3928665);  (R-HSA-432720);  (R-HSA-437239);  (R-HSA-5099900);  (R-HSA-5140745);  (R-HSA-8856825);  (R-HSA-8856828);  (R-HSA-8866427);  (R-HSA-8964038)",
        "pathway_count": 15,
        "publication_count": 441,
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        "class_list": "",
        "function": "Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]., [RefSeq]; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB, UniProtKB, UniProtKB]; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582)., [UniProtKB, PubMed, PubMed]; Clathrin light chain A facilitates small extracellular vesicle uptake to promote hepatocellular carcinoma progression., [RefSeq, PubMed]; GRK2-mediated receptor phosphorylation and Mdm2-mediated beta-arrestin2 ubiquitination drive clathrin-mediated endocytosis of G protein-coupled receptors., [RefSeq, PubMed]; Role of Clathrin Light Chains in Regulating Invadopodia Formation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4W3;B4DIN1;F5H6N3;Q2XPN5;Q53XZ1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005198 structural molecule activity;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding;GO:0042277 peptide binding;GO:0032050 clathrin heavy chain binding",
        "go_cellular_component": "GO:0030118 clathrin coat;GO:0030125 clathrin vesicle coat;GO:0098835 presynaptic endocytic zone membrane;GO:0005768 endosome;GO:0005819 spindle",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0051301 cell division;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0048488 synaptic vesicle endocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 44.4,
        "record_id": "P09496-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NP84-1",
        "uniprot_id": "TNR12_HUMAN",
        "mass": 13911.0,
        "length": 129,
        "protein_name": "Tumor necrosis factor receptor superfamily member 12A",
        "gene_name": "TNFRSF12A",
        "organism": "Human",
        "refseq_name": "tumor necrosis factor receptor superfamily member 12A precursor",
        "refseq_ac": "NP_057723",
        "gene_names_uniprotkb": "TNFRSF12A; FN14",
        "gene_names_refseq": "CD266; FN14; TNFRSF12A; TWEAKR",
        "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 12A; FGF-inducible 14; Fibroblast growth factor-inducible immediate-early response protein 14; Tweak-receptor; TweakR",
        "protein_names_refseq": "FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; tumor necrosis factor receptor superfamily member 12A precursor; tumor necrosis factor receptor superfamily member 12A; tweak-receptor; type I transmembrane protein Fn14",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51330);  (R-HSA-5668541);  (R-HSA-5676594)",
        "pathway_count": 3,
        "publication_count": 58,
        "publication_id_list": "10085077;10359578;10751351;10797013;11237011;11728344;11853672;12374738;12445828;12496418;12529173;12571250;12721620;12787562;15084608;15368291;15585864;15644327;15824857;17636564;18635759;18997792;18997794;19241374;19426221;19815541;20385556;20483727;21081755;21091114;23667509;24248355;24298274;24432023;25152365;29242379;30833945;32488085;32938616;33968037;34171305;35051231;36010968;36716919;36916753;37060824;37761958;38277520;7544915;7639698;8521496;8663299;8702708;9122217;9247583;9367155;9718306;9852070",
        "class_list": "",
        "function": "Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia. Publication Status: Online-Only, [RefSeq, PubMed]; Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer., [RefSeq, PubMed]; FN14 is the sole mediator of the multiple pathways of TWEAK-induced cell death in all TWEAK-sensitive tumor cell lines., [RefSeq, PubMed]; Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis., [RefSeq, PubMed]; Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins., [UniProtKB, PubMed]; Relief of Extracellular Matrix Deposition Repression by Downregulation of IRF1-Mediated TWEAK/Fn14 Signaling in Keloids., [RefSeq, PubMed]; TWEAK and Fn14 are overexpressed in immune-mediated necrotizing myopathy: implications for muscle damage and repair. Erratum:[Rheumatology (Oxford). 2023 Nov 2;62(11):3770. doi: 10.1093/rheumatology/kead200. PMID: 37167527], [RefSeq, PubMed]; These results indicated that TWEAK could induce pro-inflammatory reactions via fibroblast growth factor-inducible 14 (Fn14)on human umbilical vein endothelial cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DUA6;Q9HCS0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0001726 ruffle",
        "go_biological_process": "GO:0061041 regulation of wound healing;GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "Q9NP84-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y572-1",
        "uniprot_id": "RIPK3_HUMAN",
        "mass": 56887.0,
        "length": 518,
        "protein_name": "Receptor-interacting serine/threonine-protein kinase 3",
        "gene_name": "RIPK3",
        "organism": "Human",
        "refseq_name": "receptor-interacting serine/threonine-protein kinase 3",
        "refseq_ac": "NP_006862",
        "gene_names_uniprotkb": "RIPK3; RIP3",
        "gene_names_refseq": "RIP3; RIPK3",
        "protein_names_uniprotkb": "Receptor-interacting serine/threonine-protein kinase 3; 2.7.11.1; RIP-3; RIP-like protein kinase 3; Receptor-interacting protein 3",
        "protein_names_refseq": "RIP-3; RIP-like protein kinase 3; receptor interacting protein 3; receptor-interacting serine/threonine-protein kinase 3",
        "tax_id": 9606,
        "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); adult respiratory distress syndrome (Disease Ontology:DOID:11394)",
        "pathway": " (hsa:11035);  (R-HSA-168927);  (R-HSA-1810476);  (R-HSA-2562578);  (R-HSA-3295583);  (R-HSA-5213460);  (R-HSA-5675482);  (R-HSA-9013957);  (R-HSA-937041);  (R-HSA-9686347);  (R-HSA-9692913);  (R-HSA-9692916)",
        "pathway_count": 12,
        "publication_count": 142,
        "publication_id_list": "10339433;10358032;10723127;11050376;11226139;11237011;11243859;11301059;11734559;12015988;12181749;12221085;12620240;12752666;1422598;14634208;14739303;15064760;15145317;15208624;15814722;15896315;16048439;16056267;16115877;16282325;16547522;16603398;17035307;17047224;17270291;17344846;17412287;17428862;17596301;17644308;17761676;18570872;18941233;19278658;19380580;19398035;19498109;19524512;19524513;19590578;19666475;20025796;20308068;20354226;20696886;20716668;21737329;21737330;21887730;21931591;22046132;22123964;22253733;22265413;22265414;22312431;22421439;22421964;22817896;23483519;24059293;24316671;24509444;24622840;24703947;24813885;24854014;25135833;25316792;25389312;25674983;25764917;25765567;25852146;25855297;25892735;25907116;25996294;26320399;26378163;26559832;26775703;26866270;26900751;26933192;27164085;27203180;27701768;28148787;28228285;28454582;28661484;28834231;29294448;29557506;29681455;29883609;29883610;29930286;30185776;30237400;30315122;30770249;31031142;31034780;31138766;31231549;31358971;31844290;31848261;32157095;32269263;32298652;32387766;32502341;32561730;32657447;32690704;32728199;32967941;33060197;33348174;33369872;34509645;34999730;35051231;35318648;35580925;35739084;36342164;38493248;38522486;38630344;38696138;39089491;9989503",
        "class_list": "",
        "function": "(Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion., [UniProtKB, PubMed]; Derlin-1 promotes diet-induced non-alcoholic fatty liver disease via increasing RIPK3-mediated necroptosis., [RefSeq, PubMed]; RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular insights into pathogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; RIPK3 causes mitochondrial dysfunction and albuminuria in diabetic podocytopathy through PGAM5-Drp1 signaling., [RefSeq, PubMed]; Receptor-interacting protein kinase-3 (RIPK3): a new biomarker for necrotising enterocolitis in preterm infants. Publication Status: Online-Only, [RefSeq, PubMed]; Sensing of mitochondrial DNA by ZBP1 promotes RIPK3-mediated necroptosis and ferroptosis in response to diquat poisoning., [RefSeq, PubMed]; Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32657447). Necroptosis, a programmed cell death process in response to death-inducing TNF family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 14,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 14,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 14,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DJL9;C4AM87;Q5J795;Q5J796;Q6P5Y1",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.4.1.255;2.7.11.25;2.7.10.2;2.7.12.1;2.3.2.31;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;3.6.4.10;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.23;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;3.4.22.61;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;2.3.2.26;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097342 ripoptosome;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0001914 regulation of T cell mediated cytotoxicity;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0051607 defense response to virus;GO:1990000 amyloid fibril formation",
        "synthesized_glycan_count": 0,
        "hit_score": 15.8,
        "record_id": "Q9Y572-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N3J5-1",
        "uniprot_id": "PPM1K_HUMAN",
        "mass": 40997.0,
        "length": 372,
        "protein_name": "Protein phosphatase Mn(2+)-dependent 1K",
        "gene_name": "PPM1K",
        "organism": "Human",
        "refseq_name": "protein phosphatase Mn(2+)-dependent 1K",
        "refseq_ac": "NP_689755",
        "gene_names_uniprotkb": "PPM1K; PP2CM",
        "gene_names_refseq": "BCKDH; BDP; MSUDMV; PP2Ckappa; PP2Cm; PPM1K; PTMP; UG0882E07",
        "protein_names_uniprotkb": "Protein phosphatase Mn(2+)-dependent 1K; 3.1.3.16; 3.1.3.52; BCKDH; BDP; Branched-chain alpha-ketoacid dehydrogenase phosphatase; PP2C domain-containing protein phosphatase 1K; PP2C-kappa; PP2C-like mitochondrial protein; PP2C-type mitochondrial phosphoprotein phosphatase; PTMP; Protein phosphatase 2C family member; Protein phosphatase 2C isoform kappa; [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial",
        "protein_names_refseq": "PP2C domain-containing protein phosphatase 1K; PP2C-kappa; PP2C-type mitochondrial phosphoprotein phosphatase; [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial; branched-chain I+/--ketoacid dehydrogenase phosphatase; branched-chain alpha-ketoacid dehydrogenase phosphatase; protein phosphatase 1K, mitochondrial; protein phosphatase 2C family member; protein phosphatase 2C kappa; protein phosphatase Mn(2+)-dependent 1K",
        "tax_id": 9606,
        "disease": "mild variant of maple syrup urine disease (Disease Ontology:DOID:0061205); maple syrup urine disease (Disease Ontology:DOID:9269)",
        "pathway": " (hsa:152926);  (R-HSA-70895);  (R-HSA-9912529)",
        "pathway_count": 3,
        "publication_count": 86,
        "publication_id_list": "10832746;10947204;11013134;11181649;11237011;11264579;11406611;11738050;12269802;12359132;12434311;12696021;13416257;14752098;15166214;1527093;15342248;15576032;16023992;16141215;16685424;17336929;17371050;17374715;18058037;18987618;19411760;22291014;22589535;22956686;23086801;23200863;23481700;23485643;24449431;24715725;25418920;25576301;25802875;26154972;26251176;26992070;27600516;27862975;27920218;28228285;28832583;28834231;28904123;29242379;29493099;29557506;29779826;29786170;30315122;3082934;31154438;31435015;31844290;31998317;32157095;32357974;32387766;32488085;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33964402;34382495;34932366;35051231;35580925;3597357;36284347;36863088;6928646;7356336;8824301;9165094;9214289;9889013",
        "class_list": "",
        "function": "A novel member of human protein phosphatase 2C gene family named PP2Ckappa was isolated from a human fetal brain cDNA library., [RefSeq, PubMed]; Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease., [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome., [RefSeq, PubMed]; Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). At high levels of branched-chain ketoacids, dephosphorylates and activates mitochondrial BCKDH complex, a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Tightly associates with the E2 component of BCKDH complex and dephosphorylates BCKDHA on Ser-337 (PubMed:17336929, PubMed:17374715, PubMed:19411760, PubMed:22291014, PubMed:22589535, PubMed:23086801, PubMed:29779826). Regulates the reversible phosphorylation of ACLY in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. At fasting state, appears to dephosphorylate ACLY on Ser-455 and inactivate it. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxS or RxxS motifs and strictly depends on Mn(2+) ions for the phosphatase activity (PubMed:29779826). Regulates Ca(2+)-induced opening of mitochondrial transition pore and apoptotic cell death (PubMed:17374715)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The cloned phosphatase has a mitochondrial leader sequence and its amino acid sequence places it in the PP2C family like two known mitochondrial phosphatases. Erratum:[Biochem Biophys Res Commun. 2007 Oct 5;361(4):1061], [RefSeq, PubMed]; The role of PP5 and PP2C in cardiac health and disease. Review article, [RefSeq, PubMed]; This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RAZ1;Q05CT5;Q49AB5;Q4W5E6;Q56AN8;Q8IUZ7;Q8IXG7;Q8ND70;Q96NT4",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.-;1.8.1.4;2.3.1.168;2.3.1.-;1.2.4.4;3.1.3.67;3.1.3.53;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0030145 manganese ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0047385 [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity;GO:0043169 cation binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0009083 branched-chain amino acid catabolic process;GO:1902531 regulation of intracellular signal transduction;GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 8.7,
        "record_id": "Q8N3J5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P11586-1",
        "uniprot_id": "C1TC_HUMAN",
        "mass": 101531.0,
        "length": 935,
        "protein_name": "C-1-tetrahydrofolate synthase, cytoplasmic",
        "gene_name": "MTHFD1",
        "organism": "Human",
        "refseq_name": "C-1-tetrahydrofolate synthase, cytoplasmic isoform 1",
        "refseq_ac": "NP_005947",
        "gene_names_uniprotkb": "MTHFD1; MTHFC; MTHFD",
        "gene_names_refseq": "CIMAH; MTHFC; MTHFD1; MTHFD",
        "protein_names_uniprotkb": "C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase; Epididymis secretory sperm binding protein",
        "protein_names_refseq": "5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase; C-1-tetrahydrofolate synthase, cytoplasmic isoform 1; C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase; cytoplasmic C-1-tetrahydrofolate synthase; epididymis secretory sperm binding protein; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase",
        "tax_id": 9606,
        "disease": "combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia (Disease Ontology:DOID:0070742); spina bifida (Disease Ontology:DOID:0080016); neural tube defect (Disease Ontology:DOID:0080074); developmental cardiac valvular defect (Disease Ontology:DOID:0080633); Down syndrome (Disease Ontology:DOID:14250); tetralogy of Fallot (Disease Ontology:DOID:6419); cleft palate (Disease Ontology:DOID:674); abdominal aortic aneurysm (Disease Ontology:DOID:7693); colorectal cancer (Disease Ontology:DOID:9256); cleft lip (Disease Ontology:DOID:9296)",
        "pathway": " (hsa:4522);  (R-HSA-196757)",
        "pathway_count": 2,
        "publication_count": 113,
        "publication_id_list": "10091649;10347183;10828945;10978331;11237011;12384833;12665801;12937168;14654843;16171773;16408927;16552426;17000706;17129779;17308042;17962486;18369606;18767138;1881876;19424049;19948730;20068231;20498374;21163947;21238436;21813566;21876188;22223895;2248959;23409799;23481700;23934049;24275569;24733394;25418920;25633902;25645385;25892735;2605182;26108676;26375851;26728094;26768311;26853435;27707659;28510447;30315122;30397120;30429286;3053686;30626607;30779550;30833945;31092671;31154438;31222486;31530632;31848261;31998317;32119511;32157095;32161166;32423175;32658475;32897882;32938616;32983136;33053560;33163492;33214551;33691108;33968037;33981976;34019948;34078123;34211107;34357683;34509645;34561969;34725712;34904448;34932366;35051231;35100977;35138101;35154160;35251023;35318648;35561310;35580925;35894196;36010968;36215666;36241641;36284347;36913067;37217939;3801490;38336749;38665916;3871768;39302247;4066659;40914422;6323448;7726158;7852378;8218174;8522195;8662720;9519408;9611072;9753690",
        "class_list": "",
        "function": "Association Between MTHFD1 1958G > A Variant and non-Syndromic Cleft lip and Palate: An Updated Meta-Analysis., [RefSeq, PubMed]; Association of MTHFD1 gene polymorphisms and maternal smoking with risk of congenital heart disease: a hospital-based case-control study. Publication Status: Online-Only, [RefSeq, PubMed]; MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma. Publication Status: Online-Only, [RefSeq, PubMed]; The negative effect of G1958A polymorphism on MTHFD1 protein stability and HCC growth., [RefSeq, PubMed]; This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008]., [RefSeq]; Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; [Association of maternal MTHFD1 and MTHFD2 gene polymorphisms with congenital heart disease in offspring].', trans 'MTHFD1MTHFD2., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 14,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 10,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A024R652;A0A384N5Y3;B2R5Y2;G3V2B8;Q86VC9;Q9BVP5",
        "ec_number_list": "6.3.4.3;1.5.1.5;3.5.4.9;1.5.1.15",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0004329 formate-tetrahydrofolate ligase activity;GO:0004477 methenyltetrahydrofolate cyclohydrolase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007507 heart development;GO:0001843 neural tube closure;GO:0046655 folic acid metabolic process;GO:0001780 neutrophil homeostasis;GO:0009257 10-formyltetrahydrofolate biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "P11586-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43497-1",
        "uniprot_id": "CAC1G_HUMAN",
        "mass": 262472.0,
        "length": 2377,
        "protein_name": "Voltage-dependent T-type calcium channel subunit alpha-1G",
        "gene_name": "CACNA1G",
        "organism": "Human",
        "refseq_name": "voltage-dependent T-type calcium channel subunit alpha-1G isoform 16",
        "refseq_ac": "NP_001243253",
        "gene_names_uniprotkb": "CACNA1G; KIAA1123",
        "gene_names_refseq": "CACNA1G; Ca(V)T.1; Cav3.1; NBR13; SCA42ND; SCA42",
        "protein_names_uniprotkb": "Voltage-dependent T-type calcium channel subunit alpha-1G; Cav3.1c; NBR13; Voltage-gated calcium channel subunit alpha Cav3.1",
        "protein_names_refseq": "calcium channel, voltage-dependent, T type, alpha 1G subunit; cav3.1c; voltage-dependent T-type calcium channel alpha 1G subunit; voltage-dependent T-type calcium channel subunit alpha-1G isoform 16; voltage-dependent calcium channel alpha 1G subunit; voltage-gated calcium channel subunit alpha Cav3.1",
        "tax_id": 9606,
        "disease": "cerebellar ataxia type 42 (Disease Ontology:DOID:0111742); spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits (MONDO:MONDO:0060758)",
        "pathway": " (hsa:8913);  (R-HSA-419037);  (R-HSA-445355)",
        "pathway_count": 3,
        "publication_count": 67,
        "publication_id_list": "10493502;10548410;10648811;10692398;10991994;11237011;11242081;11457814;11532985;11889009;12048254;12765789;14506282;14627618;15377279;156362;16267048;16671074;17055381;18059411;18974361;1930128;19380584;20058876;22421042;22778174;23834404;24715725;24872348;2526655;26362469;26456284;26715324;26992070;2764880;27679490;2809592;28228285;28741090;28832583;28904123;29242379;29557506;29878067;30315122;30410026;31844290;32387766;32938616;33633747;34403092;34674590;34932366;35051231;36010968;37259724;37311830;3780718;38874740;8262246;8858389;9398268;9481611;9495342;9598563;9600334;9855623",
        "class_list": "",
        "function": "CaV3.2 (CACNA1H) in Primary Aldosteronism. Review article, [RefSeq, PubMed]; Downregulation of Cav3.1 T-type Calcium Channel Expression in Age-related Hearing Loss Model., [RefSeq, PubMed]; The T-type Calcium Channel Cav3.1 in Y79 Retinoblastoma Cells is Regulated by the Epidermal Growth Factor Receptor via the MAPK Signaling Pathway., [RefSeq, PubMed]; The relationship of promoter methylation of calcium voltage-gated channel alpha 1 and interleukin-16 to primary osteoarthritis., [RefSeq, PubMed]; Unmasking early colorectal cancer clues: in silico and in vitro investigation of downregulated IGF2, SOCS1, MLH1, and CACNA1G in SSA polyps. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 61,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6RA64;E7EPR0;O43498;O94770;Q19QY8;Q19QY9;Q19QZ0;Q19QZ1;Q19QZ2;Q19QZ3;Q19QZ4;Q19QZ5;Q19QZ6;Q19QZ7;Q19QZ8;Q19QZ9;Q19R00;Q19R01;Q19R02;Q19R03;Q19R04;Q19R05;Q19R06;Q19R07;Q19R08;Q19R09;Q19R10;Q19R11;Q19R12;Q19R13;Q19R15;Q19R16;Q19R17;Q19R18;Q2TAC4;Q9NYU4;Q9NYU5;Q9NYU6;Q9NYU7;Q9NYU8;Q9NYU9;Q9NYV0;Q9NYV1;Q9UHN9;Q9UHP0;Q9ULU6;Q9UNG7;Q9Y5T2;Q9Y5T3",
        "ec_number_list": "2.7.11.1",
        "go_molecular_function": "GO:0097110 scaffold protein binding;GO:0005245 voltage-gated calcium channel activity;GO:0008331 high voltage-gated calcium channel activity;GO:0008332 low voltage-gated calcium channel activity;GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005891 voltage-gated calcium channel complex;GO:0034702 monoatomic ion channel complex",
        "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0086091 regulation of heart rate by cardiac conduction;GO:0070588 calcium ion transmembrane transport;GO:0086015 SA node cell action potential;GO:0086046 membrane depolarization during SA node cell action potential",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "O43497-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9ULU8-1",
        "uniprot_id": "CAPS1_HUMAN",
        "mass": 152786.0,
        "length": 1353,
        "protein_name": "Calcium-dependent secretion activator 1",
        "gene_name": "CADPS",
        "organism": "Human",
        "refseq_name": "calcium-dependent secretion activator 1 isoform 1",
        "refseq_ac": "NP_003707",
        "gene_names_uniprotkb": "CADPS; CAPS1; CAPS; KIAA1121",
        "gene_names_refseq": "CADPS1; CADPS; CAPS1; CAPS; UNC-31",
        "protein_names_uniprotkb": "Calcium-dependent secretion activator 1; CAPS-1; Calcium-dependent activator protein for secretion 1",
        "protein_names_refseq": "CAPS-1; Ca++-dependent secretion activator; Ca2+ dependent secretion activator; Ca2+-dependent activator protein for secretion; Ca2+-regulated cytoskeletal protein; calcium-dependent activator protein for secretion 1; calcium-dependent secretion activator 1 isoform 1; calcium-dependent secretion activator 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8618)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "11237011;12659812;15857609;24715725;26992070;29557506;30742066;31092671;31562609;31638236;31844290;32157095;32350084;32938616;33592498;33691108;34171305;35051231;35169262;37938771;38253038;9289490",
        "class_list": "",
        "function": "CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress., [RefSeq, PubMed]; CAPS1 Suppresses Tumorigenesis in Cholangiocarcinoma., [RefSeq, PubMed]; CAPS1 promotes colorectal cancer metastasis through PI3K/Akt/GSK3beta/Snail signal pathway-mediated epithelial mesenchymal transformation process, [RefSeq, PubMed]; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity)., [UniProtKB]; Study revealed that CAPS1 promoted normal colonic epithelial FHC cells migration by altering the protein expression profile of exosomes derived from colorectal cancer cells cells. GW4869, an exosome inhibitor, inhibited CAPS1-induced cell migration., [RefSeq, PubMed]; This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 47,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NF60;Q13339;Q6GQQ6;Q8N2Z5;Q8N3M7;Q8NFR0;Q96BC2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0098793 presynapse;GO:0099012 neuronal dense core vesicle membrane;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis;GO:0016079 synaptic vesicle exocytosis;GO:0045921 positive regulation of exocytosis;GO:1990504 dense core granule exocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q9ULU8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P23258-1",
        "uniprot_id": "TBG1_HUMAN",
        "mass": 51170.0,
        "length": 451,
        "protein_name": "Tubulin gamma-1 chain",
        "gene_name": "TUBG1",
        "organism": "Human",
        "refseq_name": "tubulin gamma-1 chain",
        "refseq_ac": "NP_001061",
        "gene_names_uniprotkb": "TUBG1; TUBG",
        "gene_names_refseq": "CDCBM4; GCP-1; TUBG1; TUBGCP1; TUBG",
        "protein_names_uniprotkb": "Tubulin gamma-1 chain; GCP-1; Gamma-1-tubulin; Gamma-tubulin complex component 1",
        "protein_names_refseq": "gamma-tubulin complex component 1; tubulin gamma-1 chain; tubulin, gamma polypeptide",
        "tax_id": 9606,
        "disease": "muscular disease (Disease Ontology:DOID:0080000); complex cortical dysplasia with other brain malformations 4 (Disease Ontology:DOID:0090138); inclusion body myositis (Disease Ontology:DOID:3429)",
        "pathway": " (hsa:7283);  (R-HSA-2565942);  (R-HSA-380259);  (R-HSA-380270);  (R-HSA-380284);  (R-HSA-380320);  (R-HSA-5620912);  (R-HSA-8854518)",
        "pathway_count": 8,
        "publication_count": 152,
        "publication_id_list": "11076968;11237011;11840567;11956313;12207013;12221128;12364337;12852856;13678582;14580337;14654843;15498487;15705883;16357211;16462731;16890155;17574030;17646400;17719545;17959831;18037885;18378770;18477460;18521620;18566290;18615013;18694559;18801063;19004860;1904010;19081074;19648910;19940019;20068231;20230748;20308558;20399632;20558667;20643351;21273506;21347367;21422230;21548880;21565611;21620453;21725307;21792235;22094468;22179047;22365832;22433857;22641346;22653444;23141531;23141541;23253480;23348840;23400999;23530209;23603762;23747070;23769972;23789104;23921553;24053599;24089205;24107630;24231678;24469809;24715725;24982133;25047611;25313408;25418920;25532896;25576301;25645385;25880248;25892735;26154972;26811146;26992070;27600516;27846572;27920218;28063628;28218747;28228285;28467828;28514659;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29493099;29508533;29632711;29786170;30315122;30410026;30429286;30723163;31844290;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33402344;33592498;33633747;33691108;33717175;33912179;33936100;33968037;34087483;34171305;34229054;34357683;34509645;34561969;34932366;35051231;35154160;35580925;35849559;36010968;36241641;36792863;37685969;37806848;38305685;38609661;38870534;39321809;7769006;7790358;8838651;9566967;9566969",
        "class_list": "",
        "function": "Centrosome Movements Are TUBG1-Dependent. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]., [RefSeq]; TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways., [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Upregulation of TUBG1 expression promotes hepatocellular carcinoma development. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
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        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53X79;Q9BW59",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0140490 microtubule nucleator activity",
        "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007020 microtubule nucleation;GO:0000226 microtubule cytoskeleton organization;GO:0007052 mitotic spindle organization;GO:0000070 mitotic sister chromatid segregation",
        "synthesized_glycan_count": 0,
        "hit_score": 15.5,
        "record_id": "P23258-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P62837-1",
        "uniprot_id": "UB2D2_HUMAN",
        "mass": 16735.0,
        "length": 147,
        "protein_name": "Ubiquitin-conjugating enzyme E2 D2",
        "gene_name": "UBE2D2",
        "organism": "Human",
        "refseq_name": "ubiquitin-conjugating enzyme E2 D2 isoform 1",
        "refseq_ac": "NP_003330",
        "gene_names_uniprotkb": "UBE2D2; PUBC1; UBC4; UBC5B; UBCH4; UBCH5B",
        "gene_names_refseq": "E2(17)KB2; PUBC1; UBC4/5; UBC4; UBCH4; UBCH5B; UBE2D2",
        "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 D2; (E3-independent) E2 ubiquitin-conjugating enzyme D2; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2; p53-regulated ubiquitin-conjugating enzyme 1",
        "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme D2; E2 ubiquitin-conjugating enzyme D2; p53-regulated ubiquitin-conjugating enzyme 1; ubiquitin carrier protein D2; ubiquitin conjugating enzyme E2D 2; ubiquitin-conjugating enzyme E2 D2 isoform 1; ubiquitin-conjugating enzyme E2-17 kDa 2; ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5); ubiquitin-protein ligase D2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7322);  (R-HSA-1234176);  (R-HSA-168927);  (R-HSA-202424);  (R-HSA-2871837);  (R-HSA-5205685);  (R-HSA-5357905);  (R-HSA-5607764);  (R-HSA-8866652);  (R-HSA-8866654);  (R-HSA-8951664);  (R-HSA-9033241);  (R-HSA-936440);  (R-HSA-937041);  (R-HSA-9705462);  (R-HSA-983168);  (R-HSA-9954709);  (R-HSA-9954716);  (R-HSA-9956593)",
        "pathway_count": 19,
        "publication_count": 492,
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        "class_list": "",
        "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:10329681, PubMed:18042044, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694, PubMed:26475854, PubMed:28322253). Catalyzes 'Lys-48'-linked polyubiquitination (PubMed:10329681, PubMed:18042044, PubMed:18359941, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694, PubMed:26475854). Mediates the selective degradation of short-lived and abnormal proteins (PubMed:10329681, PubMed:18042044, PubMed:18359941, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694, PubMed:26475854). Functions in the E6/E6-AP-induced ubiquitination of p53/TP53 (PubMed:15280377). Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6 (PubMed:18359941, PubMed:28322253). Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection (PubMed:18703417, PubMed:20403326). Essential for viral activation of IRF3 (PubMed:19854139)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; CircUBE2D2 regulates HMGB1 through miR-885-5p to promote ovarian cancer malignancy. Publication Status: Online-Only, [RefSeq, PubMed]; Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]., [RefSeq]; The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
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        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "secondary_ac_list": "D3DQC9;P51669;Q3MN78;Q96RP6",
        "ec_number_list": "6.2.1.45;2.3.2.24;2.3.2.23;2.3.2.26;2.3.2.27;2.3.2.31;2.7.10.2;2.3.2.-;3.6.5.-;3.6.4.13;4.2.99.18;2.3.2.36;3.6.1.-;6.2.1.-;2.3.2.34;2.3.2.32;2.7.11.1;3.6.4.-;6.2.1.64;2.3.2.25;1.14.11.29;1.14.11.-;3.4.19.12",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0036211 protein modification process;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 49.5,
        "record_id": "P62837-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13620-2",
        "uniprot_id": "CUL4B_HUMAN",
        "mass": 103982.0,
        "length": 913,
        "protein_name": "Cullin-4B",
        "gene_name": "CUL4B",
        "organism": "Human",
        "refseq_name": "cullin-4B isoform 2",
        "refseq_ac": "NP_001073341",
        "gene_names_uniprotkb": "CUL4B; KIAA0695",
        "gene_names_refseq": "CUL-4B; CUL4B; MRXHF2; MRXS15; MRXSC; SFM2",
        "protein_names_uniprotkb": "Cullin-4B; CUL-4B",
        "protein_names_refseq": "cullin-4B isoform 2",
        "tax_id": 9606,
        "disease": "syndromic X-linked intellectual disability Cabezas type (Disease Ontology:DOID:0060822); intellectual disability (Disease Ontology:DOID:1059); aortic valve stenosis (Disease Ontology:DOID:1712)",
        "pathway": " (hsa:8450);  (R-HSA-110314);  (R-HSA-5696394);  (R-HSA-5696395);  (R-HSA-5696400);  (R-HSA-6781823);  (R-HSA-6781827);  (R-HSA-6782135);  (R-HSA-6782210);  (R-HSA-8951664)",
        "pathway_count": 10,
        "publication_count": 334,
        "publication_id_list": "10.1101/2023.09.13.557529;10230407;10391953;10526214;10535940;10597293;10734143;10811609;10878807;10944529;10973499;11007478;11069780;11141066;11259415;11278856;11279143;11292861;11292862;11454738;11511374;11585840;11733065;11904382;11961546;12080057;12101228;12186903;12208738;12226657;12504025;12504026;12526791;12538644;12609982;12660172;12682069;12732143;12759363;12815074;12816948;12944386;14517266;14578910;14690597;14742321;14757770;15220921;15282312;15302935;15361859;15367669;15537541;15572695;15574592;15590680;15601839;15652483;15688063;15694336;15799966;15811629;15882621;15916957;15964821;16030353;16171779;16223728;16246722;16322693;16401342;16473935;16491090;16531995;16547496;16647857;16678110;16707496;16751180;16790436;16943200;16949367;17000769;17041588;17081101;17132228;17183367;17220875;17236139;17273978;17290000;17332328;17466625;17466626;17497243;17720710;17785452;17882165;17948053;17981804;18079701;18093314;18206966;18235224;18342608;18452278;18593899;18614043;18669648;18775313;18776931;18805092;18826954;18851830;18926707;19056823;19109893;19250909;19279666;19321346;19377476;19413330;19609301;19617556;19661379;19664994;19664995;19690332;19713942;19748355;19801544;19940136;19941824;20002452;20068231;20129063;20227374;20368362;20541997;20855601;20876134;21070792;21135142;21282463;21388382;21447816;21463634;21778237;21863050;21940857;22081108;22118460;22306028;22424782;22466610;22466611;22466612;22466964;22537386;22902626;22959436;23000965;23038248;23045548;23186163;23201271;23319653;23333871;23352696;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23751493;23906714;23912815;23973375;23986495;24076655;24127601;24366543;24402227;24636985;24714562;24768535;24793695;24793696;25154395;25314029;25349211;25355947;25418920;25435140;25531226;25538220;25576301;25645385;25880248;25892735;25970626;26042670;26151477;26154972;26344709;26375851;26460955;26632597;26711351;26728094;26768311;26906416;26992070;27030794;27222660;27565346;27600516;27846572;27862975;27920218;28115426;28218747;28228285;28411811;28649982;28832583;28834231;28904123;29153394;29237092;29242379;29351928;29393594;29493099;29508533;29557506;29632711;29769354;29779948;29786170;30059200;30166453;30315122;30379171;30410026;30484775;30610225;30620550;30779550;30833945;31154438;31217245;31492838;31844290;31848261;31998317;32005965;32119511;32157095;32284348;32350084;32355176;32357974;32387766;32488085;32502341;32870666;32897882;32938616;32983136;33091337;33141586;33214551;33298915;33444648;33592498;33691108;33717175;33854232;33854239;33912179;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34405274;34509645;34561969;34725712;34932366;35051231;35132862;35138101;35254053;35318648;35513511;35580925;36010968;36241641;36284347;37541260;37938771;38253038;38254314;38331954;38665916;38764027;38838015;38937308;39531497;40307207;40596516;40914422;7559382;7700386;8078911;8168482;8681378;8692841;8876179;9130708;9326587;9699634;9716411;9771713;9790970;9875289;9887101;9891082",
        "class_list": "",
        "function": "Association of CUL4B with the pathogenesis of age-related cataract. Publication Status: Online-Only, [RefSeq, PubMed]; CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK. Publication Status: Online-Only, [RefSeq, PubMed]; Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis., [RefSeq, PubMed]; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239, PubMed:25970626). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224). With CUL4A, contributes to ribosome biogenesis (PubMed:26711351)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Phenotypic and genetic analysis of children with unexplained neurodevelopmental delay and neurodevelopmental comorbidities in a Chinese cohort using trio-based whole-exome sequencing. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 12,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 12,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 12,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 20,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 3,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1APK5;B3KVX4;B7Z5K8;Q6PIE4;Q6UP07;Q7Z673;Q9BY37;Q9UEB7;Q9UED7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0160072 ubiquitin ligase complex scaffold activity",
        "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0048708 astrocyte differentiation;GO:0007283 spermatogenesis;GO:0008283 cell population proliferation;GO:0010506 regulation of autophagy",
        "synthesized_glycan_count": 0,
        "hit_score": 35.1,
        "record_id": "Q13620-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13480-1",
        "uniprot_id": "GAB1_HUMAN",
        "mass": 76616.0,
        "length": 694,
        "protein_name": "GRB2-associated-binding protein 1",
        "gene_name": "GAB1",
        "organism": "Human",
        "refseq_name": "GRB2-associated-binding protein 1 isoform b",
        "refseq_ac": "NP_002030",
        "gene_names_uniprotkb": "GAB1",
        "gene_names_refseq": "DFNB26; GAB1",
        "protein_names_uniprotkb": "GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1",
        "protein_names_refseq": "GRB2-associated binder 1; GRB2-associated-binding protein 1 isoform b; deafness, autosomal recessive 26; growth factor receptor bound protein 2-associated protein 1",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness 26 (Disease Ontology:DOID:0110484)",
        "pathway": " (hsa:2549);  (R-HSA-109704);  (R-HSA-1236382);  (R-HSA-1257604);  (R-HSA-180292);  (R-HSA-1963642);  (R-HSA-2219530);  (R-HSA-5637810);  (R-HSA-5654689);  (R-HSA-5654695);  (R-HSA-5654710);  (R-HSA-5654720);  (R-HSA-5655253);  (R-HSA-5655291);  (R-HSA-5655302);  (R-HSA-5655332);  (R-HSA-6811558);  (R-HSA-8851907);  (R-HSA-8853659);  (R-HSA-8865999);  (R-HSA-8875555);  (R-HSA-8875656);  (R-HSA-9027276);  (R-HSA-9028335);  (R-HSA-9664565);  (R-HSA-9665348)",
        "pathway_count": 26,
        "publication_count": 288,
        "publication_id_list": "10191262;10194437;10448070;10455108;10579907;10618718;10648629;10652257;10722704;10734310;10753869;10871282;10913131;10918587;10978177;10995764;11000521;11002419;11027663;11087732;11146548;11147812;11157491;11237011;11237712;11323411;11353842;11360177;11390647;11429702;11453982;11470823;11491658;11598010;11606067;11689702;11739186;11803464;11886862;12006644;12138161;12167717;12242309;12471035;12475979;12486104;12506011;12522270;12660731;12766170;12767043;12771945;12855672;12944901;1325671;1381348;14534538;14560030;14665621;14701753;14715624;14718169;14766744;14871245;14967142;14973141;15010462;15029211;15044950;15050920;15059917;15077177;15118073;15118125;15149544;15231819;15284455;15286081;15329413;15379552;15448205;15569713;15574420;15598814;15644415;15718470;15834429;15863030;16024644;16091734;16187797;16339315;16456541;16467200;16497976;16647110;16777603;16843263;16844695;16847462;16849525;16849543;1689311;16953218;16959974;16969069;17016520;17177598;17200115;17311002;17349580;17372273;17389395;17505008;17626883;17646646;17652160;17698633;17699773;17712310;17881575;18039657;18079394;18317450;18337450;18373495;18381441;18412956;18413839;18552176;18594509;18606717;18669648;18721752;18754654;18755892;18757403;18757432;18829560;18925875;19050043;19103595;19147536;19185485;19350053;19381019;19411071;19438505;19560417;19576174;19644473;19664994;19665053;19749790;19805105;19809159;19881549;19901323;19946327;19962665;20033049;20068231;20094046;20179196;20231295;20308328;20338997;20522708;20709759;20713702;20966921;21160078;21188471;21317208;21368164;21478295;21664574;21666749;21668414;21711248;21827948;21976531;21984976;22046346;22120714;22188813;22223895;22588880;22751113;22777356;22802530;22837387;22908275;23175443;23186163;23220880;23298836;23301498;23481700;23558953;23843458;23948973;24518591;24588013;24662916;2472219;24935154;25467007;25569504;25576301;25645385;25853726;25971889;25994018;26246598;26375550;26545934;26992070;27530552;28274957;28365441;28580691;28657654;28904123;29408807;29557506;29632711;29786170;29789417;29967253;30301790;30314968;30379171;30854046;31154438;31651330;31844290;31848261;32157095;32938616;33298915;33968037;34929201;35051231;35967388;36010968;36637273;37938771;38057792;38665916;38935609;7535773;7543144;7637810;7665556;7744773;8036006;8493579;8530489;8596638;8617750;8628282;8631863;8637703;8645157;8657148;8662982;8663426;8674117;8906793;9045692;9047384;9108479;9182757;9192684;9299438;9299490;9334184;9356464;9407096;9491986;9632781;9736715;9764818;9857065;9883723;9890893;9895304",
        "class_list": "",
        "function": "Activated Gab1 drives hepatocyte proliferation and anti-apoptosis in liver fibrosis via potential involvement of the HGF/c-Met signaling axis. Publication Status: Online-Only, [RefSeq, PubMed]; Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807)., [UniProtKB, PubMed]; Association of GAB1 gene with asthma susceptibility and the efficacy of inhaled corticosteroids in children. Publication Status: Online-Only, [RefSeq, PubMed]; GAB1 as a Marker of Recurrence in Anterior Skull Base Meningioma., [RefSeq, PubMed]; Molecular profile reveals immune-associated markers of medulloblastoma for different subtypes. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 71,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K152;Q4W5G2;Q6P1W2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0035591 signaling adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005911 cell-cell junction",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0042311 vasodilation",
        "synthesized_glycan_count": 0,
        "hit_score": 29.2,
        "record_id": "Q13480-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q12948-1",
        "uniprot_id": "FOXC1_HUMAN",
        "mass": 56789.0,
        "length": 553,
        "protein_name": "Forkhead box protein C1",
        "gene_name": "FOXC1",
        "organism": "Human",
        "refseq_name": "forkhead box protein C1",
        "refseq_ac": "NP_001444",
        "gene_names_uniprotkb": "FOXC1; FKHL7; FREAC3",
        "gene_names_refseq": "ARA; ASGD3; FKHL7; FOXC1; FREAC-3; FREAC3; IGDA; IHG1; IRID1; RIEG3",
        "protein_names_uniprotkb": "Forkhead box protein C1; FREAC-3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3",
        "protein_names_refseq": "forkhead box C1 protein; forkhead box protein C1; forkhead, drosophila, homolog-like 7; forkhead-related activator 3; forkhead-related protein FKHL7; forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7; myeloid factor-delta",
        "tax_id": 9606,
        "disease": "anterior segment dysgenesis 3 (Disease Ontology:DOID:0080608); Axenfeld-Rieger syndrome type 3 (Disease Ontology:DOID:0110122); buphthalmos (Disease Ontology:DOID:11211); Axenfeld-Rieger syndrome (Disease Ontology:DOID:14686); glaucoma (Disease Ontology:DOID:1686); invasive ductal carcinoma (Disease Ontology:DOID:3008); congestive heart failure (Disease Ontology:DOID:6000)",
        "pathway": " (hsa:2296);  (R-HSA-9761174);  (R-HSA-9830674)",
        "pathway_count": 3,
        "publication_count": 104,
        "publication_id_list": "10.1101/2023.09.13.557529;11170889;11179011;11589884;11740218;11782474;12408963;12454026;12533514;12592227;12614756;14506133;14578375;15277473;15299087;15477465;15684392;16449236;16492674;16936096;17210863;17653043;17993506;18212344;18452278;18484311;18669648;18676636;18691976;19279310;19413330;19793056;20068231;20406990;20881294;22493429;22991501;23186163;23239455;23301498;24357672;24715725;24914578;25576301;25645385;25786029;25892735;26154972;26565916;27804176;27907090;28832583;29242379;29331515;29557506;30379171;30429286;30620550;30779550;30833945;31154438;31222486;31492838;31844290;31848261;32157095;32161166;32502341;32938616;33123756;33214551;33968037;33981976;34019948;34171305;34185709;34211107;34846842;35051231;35138101;35254053;35289036;35513511;35580925;36241641;36284347;37340703;37541260;37683586;37938771;38183514;38580085;38634789;38838015;39093497;39430239;39531497;39534244;40416363;40596516;7957066;8499623;9620769;9792859",
        "class_list": "",
        "function": "DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; FOXC1 transcriptionally suppresses ABHD5 to inhibit the progression of renal cell carcinoma through AMPK/mTOR pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Proximal telomeric decompaction due to telomere shortening drives FOXC1-dependent myocardial senescence., [RefSeq, PubMed]; Reciprocal regulation of forkhead box C1 and L1 cell adhesion molecule contributes to triple-negative breast cancer progression., [RefSeq, PubMed]; This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain.  The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development.  Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]., [RefSeq]; USP10 promotes pancreatic ductal adenocarcinoma progression by attenuating FOXC1 protein degradation to activate the WNT signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Variants in FOXC1 and FOXC2 identified in patients with conotruncal heart defects., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 23,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 7,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86UP7;Q9BYM1;Q9NUE5;Q9UDD0;Q9UP06",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000792 heterochromatin",
        "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0048341 paraxial mesoderm formation;GO:1901491 negative regulation of lymphangiogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "Q12948-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P57078-1",
        "uniprot_id": "RIPK4_HUMAN",
        "mass": 91611.0,
        "length": 832,
        "protein_name": "Receptor-interacting serine/threonine-protein kinase 4",
        "gene_name": "RIPK4",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "RIPK4; ANKRD3; DIK",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Receptor-interacting serine/threonine-protein kinase 4; 2.7.11.1; Ankyrin repeat domain-containing protein 3; PKC-delta-interacting protein kinase",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "popliteal pterygium syndrome (Disease Ontology:DOID:0060055); CHAND syndrome (MONDO:MONDO:0008959)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 39,
        "publication_id_list": "12446564;17344846;21931591;22197488;22197489;23481700;23610050;25576301;25645385;25691407;26129644;27600516;29557506;29786170;30429286;30484775;30779550;30833945;31154438;31222486;31844290;31848261;32157095;32161166;32488085;32938616;33968037;33981976;34087483;34171305;34405274;34561969;35051231;35318648;35494241;35580925;36010968;36241641;36284347",
        "class_list": "",
        "function": "Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564)., [UniProtKB, PubMed, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96KH0",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043588 skin development;GO:0002009 morphogenesis of an epithelium",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "P57078-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P61619-1",
        "uniprot_id": "S61A1_HUMAN",
        "mass": 52265.0,
        "length": 476,
        "protein_name": "Protein transport protein Sec61 subunit alpha isoform 1",
        "gene_name": "SEC61A1",
        "organism": "Human",
        "refseq_name": "protein transport protein Sec61 subunit alpha isoform 1 isoform 1",
        "refseq_ac": "NP_037468",
        "gene_names_uniprotkb": "SEC61A1; SEC61A",
        "gene_names_refseq": "ADTKD5; CVID15; HNFJ4; HSEC61; SEC61A1; SEC61A; SEC61",
        "protein_names_uniprotkb": "Protein transport protein Sec61 subunit alpha isoform 1; Sec61 alpha-1",
        "protein_names_refseq": "SEC61 translocon alpha 1 subunit; Sec61 alpha 1 subunit; Sec61 alpha-1; protein transport protein SEC61 alpha subunit; protein transport protein Sec61 subunit alpha isoform 1 isoform 1; protein transport protein Sec61 subunit alpha; sec61 homolog",
        "tax_id": 9606,
        "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); autosomal dominant tubulointerstitial kidney disease 5 (Disease Ontology:DOID:0061120); common variable immunodeficiency (Disease Ontology:DOID:12177); immunodeficiency, common variable, 15 (MONDO:MONDO:0958013); neutropenia, severe congenital, 11, autosomal dominant (MONDO:MONDO:0958017)",
        "pathway": " (hsa:29927);  (R-HSA-1236974);  (R-HSA-1799339)",
        "pathway_count": 3,
        "publication_count": 112,
        "publication_id_list": "11237011;11964406;12475939;12853463;16469117;18166647;18455985;18692471;19217269;20444697;22153078;22375059;22424782;23481700;23613522;23783831;24366607;25083866;25418920;25576301;25645385;25880248;25892735;26154972;26811146;26992070;27392076;27452731;27600516;27846572;27920218;28063628;28218747;28228285;28510447;28514659;28782633;28832583;28834231;28860189;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29719251;29769354;29786170;30315122;30524438;31154438;31217245;31530632;31844290;31848261;32119511;32157095;32161166;32325141;32350084;32357974;32387766;32488085;32502341;32814900;32820719;32897882;32938616;32983136;33185949;33214551;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34405274;34509645;34561969;34725712;34932366;35051231;35064074;35154160;35318648;35580925;36010968;36215666;36241641;36261522;36284347;36697828;37938771;38664472;38665916;8616892;9631292",
        "class_list": "",
        "function": "Comparative analysis of SEC61A1 mutant R236C in two patient-derived cellular platforms. Publication Status: Online-Only, [RefSeq, PubMed]; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939, PubMed:22375059, PubMed:28782633, PubMed:29719251, PubMed:32814900). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:8616892). Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (PubMed:28782633). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Phenylbutyrate rescues the transport defect of the Sec61alpha mutations V67G and T185A for renin. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P38378;P57726;Q5JPF8;Q8N0Z4;Q8N3U3;Q8NC71;Q9BU16;Q9Y2R3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005048 signal sequence binding;GO:0043022 ribosome binding;GO:0008320 protein transmembrane transporter activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005784 Sec61 translocon complex",
        "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0045048 protein insertion into ER membrane;GO:0006613 cotranslational protein targeting to membrane;GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0031204 post-translational protein targeting to membrane, translocation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "P61619-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UDX3-1",
        "uniprot_id": "S14L4_HUMAN",
        "mass": 46644.0,
        "length": 406,
        "protein_name": "SEC14-like protein 4",
        "gene_name": "SEC14L4",
        "organism": "Human",
        "refseq_name": "SEC14-like protein 4 isoform b",
        "refseq_ac": "NP_001154840",
        "gene_names_uniprotkb": "SEC14L4; TAP3",
        "gene_names_refseq": "SEC14L4; TAP3",
        "protein_names_uniprotkb": "SEC14-like protein 4; Tocopherol-associated protein 3",
        "protein_names_refseq": "SEC14-like 4; SEC14-like protein 4 isoform b; SEC14-like protein 4; SEC14p-like protein TAP3; tocopherol-associated protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284904)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;12757856;15033454;18477386;20012369;25892735;27397612;29789417;30379171;32938616",
        "class_list": "",
        "function": "Discusses cloning of rat SEC14-like protein 3 and mentions three human SPF-related genes, known as SEC14-like protein 1, 2 and 3., [RefSeq, PubMed]; Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids., [UniProtKB]; The isolation of an alternatively spliced hTAP3 cDNA and a polymorphism within the coding region of the hTAP3/SEC14L4 gene, is reported., [RefSeq, PubMed]; The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5D6W7;A6NCV4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9UDX3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P67809-1",
        "uniprot_id": "YBOX1_HUMAN",
        "mass": 35924.0,
        "length": 324,
        "protein_name": "Y-box-binding protein 1",
        "gene_name": "YBX1",
        "organism": "Human",
        "refseq_name": "Y-box-binding protein 1",
        "refseq_ac": "NP_004550",
        "gene_names_uniprotkb": "YBX1; NSEP1; YB1",
        "gene_names_refseq": "BP-8; CBF-A; CSDA2; CSDB; DBPB; EFI-A; MDR-NF1; NSEP-1; NSEP1; YB-1; YB1; YBX1",
        "protein_names_uniprotkb": "Y-box-binding protein 1; CBF-A; CCAAT-binding transcription factor I subunit A; DBPB; DNA-binding protein B; EFI-A; Enhancer factor I subunit A; Nuclease-sensitive element-binding protein 1; Y-box transcription factor; YB-1",
        "protein_names_refseq": "CCAAT-binding transcription factor I subunit A; DNA-binding protein B; Y-box transcription factor; Y-box-binding protein 1; enhancer factor I subunit A; major histocompatibility complex, class II, Y box-binding protein I; nuclease-sensitive element-binding protein 1",
        "tax_id": 9606,
        "disease": "myocardial infarction (Disease Ontology:DOID:5844)",
        "pathway": " (hsa:4904);  (R-HSA-2173796);  (R-HSA-72163);  (R-HSA-72165);  (R-HSA-72203);  (R-HSA-877300);  (R-HSA-9017802);  (R-HSA-9770562);  (R-HSA-9918476);  (R-HSA-9918481);  (R-HSA-9918487)",
        "pathway_count": 11,
        "publication_count": 389,
        "publication_id_list": "10.1101/2023.09.13.557529;10022869;10067896;10199400;10207048;10669729;10817758;10882114;10986460;11007770;11013220;11014198;11060040;11101529;11233976;11237011;11274402;11333026;11424093;11427533;11607023;11698476;11747608;11851341;11972023;11991638;12040185;12150994;12176931;12411573;12414731;12438563;12446674;12477934;12604611;12915721;12917425;1396683;14519844;14559993;14586410;14625303;14657019;14713954;14718551;14722222;14749727;14762106;15037765;15084397;1508672;15100235;15136035;15143187;15146077;15150273;15322115;15388922;15530433;15565158;15592455;15806160;16237089;16278212;16314458;16319104;16354698;16467876;16809785;16964243;17081983;17095540;17125875;17128255;17287340;17289661;17322306;17332742;17438144;17487921;17606899;17875215;17932509;17940139;18288197;18322460;18335541;18362138;18452278;18491316;18568018;18591661;18593880;18669648;18707149;18767875;18809583;18851979;1891370;19029303;19036157;19052544;19103666;19165350;19217410;19413330;19415658;19483673;19536130;19561594;19640841;19651622;19664994;19664995;19690332;19914168;20049711;20068231;20130243;20166139;20304997;20305658;20363976;20423332;20595680;20695905;20844753;20980672;21295486;21392397;21406692;21423216;21536652;21695211;21740066;2176635;21911577;22110043;22275377;22365833;22424782;22813749;22959432;22961380;23061660;23186163;23222130;23236153;23345524;23481700;23719902;23874216;24076191;24103640;24149845;24196718;24217978;24275569;24304693;24316715;24349210;24407421;24417533;24448447;24554780;24715725;24737827;24770864;24885403;24914973;24981863;25229427;2524422;25301780;25301781;25418920;25502872;25555158;25576301;2558966;25645385;25802875;25810538;26092250;26154972;26318844;26355086;26375851;26385511;26420826;26735137;26758079;26811146;26845719;26929215;26969736;26992070;27080258;27108190;27377154;27397581;27452731;27459055;27510544;27559612;27600516;27683217;27751836;27846572;27920218;28062851;28063628;28076346;28077578;28096519;28107702;28123588;28218747;28228285;28341602;28415756;28467828;28502770;28514659;28781166;28832583;28834231;28904123;28911096;29073095;29117567;29186539;29242379;29274231;29301961;29314611;29317506;29360106;29361316;29393594;29437277;29493099;29508533;29557506;29605689;29632046;29632711;2963332;29712925;2977358;29786170;29789417;29902443;30126195;30139799;30192525;30257008;30315122;30315277;30356079;30410026;30429286;30484775;30599162;30705154;30728453;30765414;30779550;30833945;30975767;31010234;31092671;31222486;31358969;31373491;31409651;31530632;31611695;3174636;31844290;31848261;31906126;31936902;32013098;32028981;32112110;32119511;32157095;32161166;32178290;32179686;32265295;32329775;32350084;32387766;32488085;32494006;32710623;32816001;32890404;32931865;32938616;32973139;32983136;33177556;33214551;33239784;33243851;33298915;33379356;33392160;33446560;33465208;33516877;33592498;33633747;33911076;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34272387;34301950;34357683;34561969;34696522;34725712;34822310;35022570;35051231;35138101;35154160;35177536;35215846;35251023;35318648;35385551;35452674;35561310;35580925;35585045;36010968;36215666;36241641;37217939;3757028;38177122;38665916;39114035;39168971;39400789;40596516;40721081;40914422;7510216;7514165;7530745;7615558;7617032;7657660;7673114;7690989;7796299;8156998;8176225;8188694;8352591;8483949;8530158;8550631;8566756;8608946;8631301;8835860;9016565;9111318;9143706;9242493;9409616;9512519;9524131;9539711;9659921;9671485;9701291;9731529",
        "class_list": "",
        "function": "DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; TAGLN2 induces resistance signature ISGs by activating AKT-YBX1 signal with dual pathways and mediates the IFN-related DNA damage resistance in gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The secretion of YB-1 by mesangial and monocytic cells after inflammatory challenges, is reported., [RefSeq, PubMed]; This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]., [RefSeq]; YB-1 participates in a wide variety of DNA/RNA-dependent events, including DNA reparation, pre-mRNA transcription and splicing, mRNA packaging, and regulation of mRNA stability and translation. [review] Review article, [RefSeq, PubMed]; YBX1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma via transcriptional regulation of PLRG1. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P16990;P16991;Q14972;Q15325;Q5FVF0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:1903608 protein localization to cytoplasmic stress granule;GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 40.0,
        "record_id": "P67809-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BRK5-1",
        "uniprot_id": "CAB45_HUMAN",
        "mass": 41807.0,
        "length": 362,
        "protein_name": "45 kDa calcium-binding protein",
        "gene_name": "SDF4",
        "organism": "Human",
        "refseq_name": "45 kDa calcium-binding protein isoform 1 precursor",
        "refseq_ac": "NP_057631",
        "gene_names_uniprotkb": "SDF4; CAB45; PSEC0034",
        "gene_names_refseq": "Cab45; SDF-4; SDF4",
        "protein_names_uniprotkb": "45 kDa calcium-binding protein; Cab45; SDF-4; Stromal cell-derived factor 4",
        "protein_names_refseq": "45 kDa calcium-binding protein isoform 1 precursor; 45 kDa calcium-binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51150)",
        "pathway_count": 1,
        "publication_count": 77,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;11237011;16303743;16959974;17442889;18077418;18292551;18446792;18512783;23186163;23328677;23584533;24275569;25418920;25502872;25813380;25880248;26154972;26811146;26992070;27846572;28467828;28832583;28904123;29242379;29317506;29393594;29437277;29508533;29557506;29632046;29632711;29774024;30410026;30429286;30459171;30626607;31020640;31217245;31611695;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33298915;33392160;33592498;33912179;33968037;33981976;34087483;34171305;34326834;34357683;34405274;34433824;34509645;34561969;35051231;35154160;35251023;35494241;35580925;36010968;36215666;36241641;36284347;36398980;36606322;38665916;9254016",
        "class_list": "",
        "function": "Cab45 deficiency leads to the mistargeting of progranulin and prosaposin and aberrant lysosomal positioning., [RefSeq, PubMed]; In a yeast two-hybrid screen the EF-hand Ca(2+)-binding protein Cab45 was identified as an interaction partner of Munc18b., [RefSeq, PubMed]; Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini., [UniProtKB]; LINC00173 facilitates tumor progression by stimulating RAB1B-mediated PA2G4 and SDF4 secretion in nasopharyngeal carcinoma., [RefSeq, PubMed]; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment., [UniProtKB]; SDF4 Is a Prognostic Factor for 28-Days Mortality in Patients With Sepsis via Negatively Regulating ER Stress. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a stromal cell derived factor that is a member of the CREC protein family. The encoded protein contains six EF-hand motifs and calcium-binding motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 9,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 6,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AME5;B1AME6;B2RDF1;B4DSM1;Q53G52;Q53HQ9;Q8NBQ3;Q96AA1;Q9NZP7;Q9UN53",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0045471 response to ethanol;GO:0045444 fat cell differentiation;GO:0099558 maintenance of synapse structure;GO:0017156 calcium-ion regulated exocytosis;GO:0021549 cerebellum development",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "Q9BRK5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NS00-1",
        "uniprot_id": "C1GLT_HUMAN",
        "mass": 42203.0,
        "length": 363,
        "protein_name": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1",
        "gene_name": "C1GALT1",
        "organism": "Human",
        "refseq_name": "glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1",
        "refseq_ac": "NP_064541",
        "gene_names_uniprotkb": "C1GALT1",
        "gene_names_refseq": "C1GALT1; C1GALT; T-synthase",
        "protein_names_uniprotkb": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; 2.4.1.122; B3Gal-T8; Beta-1,3-galactosyltransferase; C1GalT1; Core 1 O-glycan T-synthase; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; Core 1 beta1,3-galactosyltransferase 1; Core 1 beta3-Gal-T1",
        "protein_names_refseq": "B3Gal-T8; core 1 O-glycan T-synthase; core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; core 1 beta3-Gal-T1; epididymis secretory sperm binding protein; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1",
        "tax_id": 9606,
        "disease": "autoimmune disease of blood (Disease Ontology:DOID:0060050)",
        "pathway": " (hsa:56913);  (R-HSA-5083632);  (R-HSA-913709)",
        "pathway_count": 3,
        "publication_count": 63,
        "publication_id_list": "10330415;10430883;10753916;11042166;11237011;11283017;11304796;11677243;11821425;12464682;12855678;1329093;15486459;15560372;15620693;16251947;17113861;17228361;18061573;18537974;19357720;22183981;22645359;23481700;24643043;26992070;28832583;29242379;29393594;29493099;29557506;29632711;29930379;30315122;31154438;31844290;32157095;32350084;32488085;32502341;32938616;32983136;33298915;33691108;33912179;33968037;34357683;35051231;35251023;35504880;35864552;36284347;37040171;38622340;38662050;39126245;7655172;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins (PubMed:11677243). Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; High core 1beta1,3-galactosyltransferase 1 expression is associated with poor prognosis and promotes cellular radioresistance in lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression., [RefSeq, PubMed]; O-GlcNAcylation determines the function of the key O-GalNAc glycosyltransferase C1GalT1 in bladder cancer., [RefSeq, PubMed]; The present study suggested that the polymorphisms of C1GALT1 gene were associated with the genetic susceptibility to IgAN in Chinese population. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010]., [RefSeq]; These results suggest that the intracellular dynamics of C1GalT is controlled by its specific molecular chaperon, Cosmc, in association with core 1 synthase activity., [RefSeq, PubMed]; Tn syndrome is associated with a somatic mutation in Cosmc, a gene on the X chromosome that encodes a molecular 'chaperone' that is required for the proper folding and hence full activity of T-synthase, [RefSeq, PubMed]; Truncation of GalNAc-type O-glycans Suppresses CD44-mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 426,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "prognostic",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96QH4;Q9BTU1",
        "ec_number_list": "2.4.1.122",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0001822 kidney development",
        "synthesized_glycan_count": 3300,
        "hit_score": 6.9,
        "record_id": "Q9NS00-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96Q07-1",
        "uniprot_id": "BTBD9_HUMAN",
        "mass": 69188.0,
        "length": 612,
        "protein_name": "BTB/POZ domain-containing protein 9",
        "gene_name": "BTBD9",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing protein 9 isoform a",
        "refseq_ac": "NP_001092742",
        "gene_names_uniprotkb": "BTBD9; KIAA1880",
        "gene_names_refseq": "BTBD9; dJ322I12.1",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein 9",
        "protein_names_refseq": "BTB (POZ) domain containing 9; BTB/POZ domain-containing protein 9 isoform a; BTB/POZ domain-containing protein 9",
        "tax_id": 9606,
        "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); restless legs syndrome, susceptibility to, 6 (MONDO:MONDO:0012636)",
        "pathway": " (hsa:114781)",
        "pathway_count": 1,
        "publication_count": 58,
        "publication_id_list": "11237011;17634447;17637780;18216367;18363860;19223043;19279021;22658601;23481700;25576301;25892735;26154972;27600516;28228285;28329290;28514659;28832583;28904123;29242379;29493099;29557506;29632711;29769354;29786170;30429286;30779550;30833945;31092671;31154438;31530632;31844290;31848261;32157095;32327643;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33367529;33592498;33691108;33717175;33936100;33968037;33981976;34171305;34357683;34509645;34561969;35051231;35580925;36010968;36241641;36284347",
        "class_list": "",
        "function": "Among the known loci, BTBD9 seems to be the most consistent in its effect on RLS across populations. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; BTBD9, was recently linked to restless legs syndrome, periodic limb movements and iron status in humans Review article, [RefSeq, PubMed]; Molecular analysis of homeostatic iron regulator, transmembrane protease serine-6, and BTB domain-containing protein-9 variants and iron parameters in blood donors., [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Results confirmed the association of BTBD9 and MAP2K5/SKOR1 with primary Restless Legs Syndrome in Chinese population, [RefSeq, PubMed]; The CRL3(BTBD9) E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration. Publication Status: Online-Only, [RefSeq, PubMed]; This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome and may also be associated with Tourette Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]., [RefSeq]; We have discovered a variant associated with susceptibility to periodic limb movements in sleep. GeneRIF: Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q494V9;Q494W1;Q96M00",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0050804 modulation of chemical synaptic transmission;GO:0048512 circadian behavior",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "Q96Q07-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15672-1",
        "uniprot_id": "TWST1_HUMAN",
        "mass": 20954.0,
        "length": 202,
        "protein_name": "Twist-related protein 1",
        "gene_name": "TWIST1",
        "organism": "Human",
        "refseq_name": "twist-related protein 1",
        "refseq_ac": "NP_000465",
        "gene_names_uniprotkb": "TWIST1; BHLHA38; TWIST",
        "gene_names_refseq": "ACS3; BPES2; BPES3; CRS1; CRS; CSO; SCS; SWCOS; TWIST1; TWIST; bHLHa38",
        "protein_names_uniprotkb": "Twist-related protein 1; Class A basic helix-loop-helix protein 38; H-twist; bHLHa38",
        "protein_names_refseq": "B-HLH DNA binding protein; H-twist; TWIST homolog of drosophila; class A basic helix-loop-helix protein 38; twist basic helix-loop-helix transcription factor 1; twist homolog 1; twist-related protein 1",
        "tax_id": 9606,
        "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); craniosynostosis 1 (Disease Ontology:DOID:0061010); Sweeney-Cox syndrome (Disease Ontology:DOID:0080538); acrocephalosyndactylia (Disease Ontology:DOID:12960); Saethre-Chotzen syndrome (Disease Ontology:DOID:14768); breast cancer (Disease Ontology:DOID:1612); breast carcinoma (Disease Ontology:DOID:3459); pulmonary fibrosis (Disease Ontology:DOID:3770); pulmonary hypertension (Disease Ontology:DOID:6432)",
        "pathway": " (hsa:7291);  (R-HSA-6785807);  (R-HSA-8878166);  (R-HSA-8939902);  (R-HSA-9725371);  (R-HSA-9764725)",
        "pathway_count": 6,
        "publication_count": 196,
        "publication_id_list": "10023775;10215629;10219247;10369418;10465122;10510379;10572046;10586089;10655587;10867011;10911365;11058569;11084045;11104795;11120780;11169414;11237011;11278437;11278729;11356008;11404481;11463377;11751994;11754069;11857736;11912130;11960372;12000792;12223527;12242343;12391164;12434152;12434156;12553906;12600988;12700765;12738770;12748172;12832402;12923053;14634100;14712222;15030764;15116091;15261459;15542832;15584925;15703179;15805299;15869882;15950906;16007214;16009132;16048438;16107692;16115867;16205632;16236134;16397018;16407259;16421188;16451196;16510571;16540365;16606674;16728642;17110082;17111047;17130829;17142326;17171635;17343269;17416736;17427945;17458857;17572495;17690253;17786208;17922009;18024471;18097461;18223689;18243101;18353781;18447642;18541707;18644974;19124156;19144722;19185846;19397496;20015877;20400976;20418909;20493732;20871592;21102457;21252155;21502402;21559372;21689689;21715655;21730069;21913213;21931630;21937440;21994466;22046235;22065775;22158034;22205702;22383755;22422618;22544321;22693070;22851691;22955283;23086340;23124025;23172665;23403054;23455323;23466526;23555662;23943595;23967200;24060861;24097101;24743777;24850862;25234944;25260729;25728771;25818168;25893917;25981568;26091038;26212009;26778333;26959880;26975371;27553022;28121444;28369379;28915063;29588546;29729076;30692217;30898548;31366041;31390744;31434245;31848261;32161166;32387766;32679125;33608512;35008676;35138000;35292107;35851744;37217939;37736724;37938771;38963044;39024569;39032603;39242200;7510216;7512451;7529288;7795521;7796300;7898939;7907877;8085155;8602263;8621622;8663118;8668165;8797861;8816495;8988166;8988167;8995765;9013879;9073070;9182764;9207800;9215678;9651359;9723655;9736340;9822675;9874564;9930702",
        "class_list": "",
        "function": "Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; DNA hypermethylation of tumor suppressor genes TWIST1, GATA4, MUS81 and NTRK1 in endometrial hyperplasia., [RefSeq, PubMed]; Inhibition of FBP1 expression by KMT5A through TWIST1 methylation is one of the mechanisms leading to chemoresistance in breast cancer., [RefSeq, PubMed]; TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis in Crohn's disease. Publication Status: Online-Only, [RefSeq, PubMed]; The Role of Twist1 in Chronic Pancreatitis-Associated Pancreatic Stellate Cells., [RefSeq, PubMed]; This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. [provided by RefSeq, Jul 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 9,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D128;Q92487;Q99804",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:2000780 negative regulation of double-strand break repair;GO:0060900 embryonic camera-type eye formation;GO:2000793 cell proliferation involved in heart valve development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 20.1,
        "record_id": "Q15672-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75936-1",
        "uniprot_id": "BODG_HUMAN",
        "mass": 44715.0,
        "length": 387,
        "protein_name": "Gamma-butyrobetaine dioxygenase",
        "gene_name": "BBOX1",
        "organism": "Human",
        "refseq_name": "gamma-butyrobetaine dioxygenase",
        "refseq_ac": "NP_003977",
        "gene_names_uniprotkb": "BBOX1; BBH; BBOX",
        "gene_names_refseq": "BBH; BBOX1; BBOX; G-BBH; gamma-BBH",
        "protein_names_uniprotkb": "Gamma-butyrobetaine dioxygenase; 1.14.11.1; Gamma-BBH; Gamma-butyrobetaine hydroxylase; Gamma-butyrobetaine,2-oxoglutarate dioxygenase",
        "protein_names_refseq": "butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; gamma-butyrobetaine dioxygenase; gamma-butyrobetaine,2-oxoglutarate dioxygenase 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8424);  (R-HSA-71262)",
        "pathway_count": 2,
        "publication_count": 19,
        "publication_id_list": "10702312;11237011;11431483;11802770;15754339;20599753;29065368;2925663;29557506;29786170;30819181;30914451;3110140;31844290;32515533;35506252;6497835;6795186;9753662",
        "class_list": "",
        "function": "BBOX 1 might be one of several genes that play a role in polygenic susceptibility to schizophrenia., [RefSeq, PubMed]; BBOX1 antisense RNA 1 facilitates CC progression by upregulating HOXC6 expression via miR-361-3p and HuR., [RefSeq, PubMed]; Catalyzes the formation of L-carnitine from gamma-butyrobetaine., [UniProtKB, PubMed, PubMed]; Long non-coding RNA BBOX1-antisense RNA 1 enhances cell proliferation and migration and suppresses apoptosis in oral squamous cell carcinoma via the miR-3940-3p/laminin subunit gamma 2 axis., [RefSeq, PubMed]; This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. [provided by RefSeq, Jul 2008]., [RefSeq]; Urinary BBOX1 might serve as a promising biomarker of diabetic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8L7;D3DQZ1;Q6IBJ2",
        "ec_number_list": "1.14.11.1",
        "go_molecular_function": "GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0008336 gamma-butyrobetaine dioxygenase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0045329 carnitine biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "O75936-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9ULB5-1",
        "uniprot_id": "CADH7_HUMAN",
        "mass": 87086.0,
        "length": 785,
        "protein_name": "Cadherin-7",
        "gene_name": "CDH7",
        "organism": "Human",
        "refseq_name": "cadherin-7 isoform 2 precursor",
        "refseq_ac": "NP_001304143",
        "gene_names_uniprotkb": "CDH7; CDH7L1",
        "gene_names_refseq": "CDH7L1; CDH7",
        "protein_names_uniprotkb": "Cadherin-7",
        "protein_names_refseq": "cadherin 7, type 2; cadherin-7 isoform 2 precursor",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:1005);  (R-HSA-418990)",
        "pathway_count": 2,
        "publication_count": 21,
        "publication_id_list": "10.1038/emboj.2013.79;10225955;10861224;10995570;11237011;12050160;16467305;17967169;19200257;19354288;23481700;23584533;24554215;25372031;29557506;32157095;34561969;35051231;7806582;9219219;9845526",
        "class_list": "",
        "function": "Cadherin-7 interacts with melanoma inhibitory activity protein and negatively modulates melanoma cell migration., [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB]; Our results support CDH7 to be a risk factor of major depressive disorder in the Han Chinese population, [RefSeq, PubMed]; This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types. Mutations in this gene may be associated with bipolar disease in human patients. This gene is present in a gene cluster on chromosome 18. [provided by RefSeq, May 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 47,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9H157",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016342 catenin complex",
        "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0098609 cell-cell adhesion;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q9ULB5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13489-1",
        "uniprot_id": "BIRC3_HUMAN",
        "mass": 68372.0,
        "length": 604,
        "protein_name": "Baculoviral IAP repeat-containing protein 3",
        "gene_name": "BIRC3",
        "organism": "Human",
        "refseq_name": "baculoviral IAP repeat-containing protein 3",
        "refseq_ac": "NP_001156",
        "gene_names_uniprotkb": "BIRC3; API2; MIHC; RNF49",
        "gene_names_refseq": "AIP1; API2; BIRC3; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; MIHC; RNF49; c-IAP2",
        "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 3; 2.3.2.27; API2; Apoptosis inhibitor 2; C-IAP2; Cellular inhibitor of apoptosis 2; IAP homolog C; Inhibitor of apoptosis protein 1; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF-signaling complex protein 1; hIAP-1; hIAP1",
        "protein_names_refseq": "RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1; apoptosis inhibitor 2; baculoviral IAP repeat-containing protein 3; cellular inhibitor of apoptosis 2; inhibitor of apoptosis protein 1; mammalian IAP homolog C",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (Disease Ontology:DOID:0050909); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); colon cancer (Disease Ontology:DOID:219); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); gallbladder carcinoma (Disease Ontology:DOID:4948); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:330);  (R-HSA-168638);  (R-HSA-168927);  (R-HSA-5213460);  (R-HSA-5357786);  (R-HSA-5357905);  (R-HSA-5357956);  (R-HSA-5668541);  (R-HSA-5675482);  (R-HSA-5676594);  (R-HSA-5689880);  (R-HSA-937041)",
        "pathway_count": 12,
        "publication_count": 266,
        "publication_id_list": "10085077;10224040;10233894;10329646;10359578;10444327;10521396;10702308;10797013;10837247;10982817;11066071;11087742;11098060;11181075;11237011;11427719;11460167;11566882;11577081;11728344;11853672;11923872;12167698;12374738;12514169;12527755;12529173;12571250;12709429;12721308;12721620;12787562;12791997;12796777;12887920;12917689;12917691;14514672;14633987;14661020;14716293;15024054;15053880;15064760;15084608;15258597;15327770;15368291;15585864;15620648;15644327;15665297;15814722;15824857;15870263;15916963;16115877;16214042;16260783;16282325;16547522;16603398;16682944;16829951;16829952;16901786;16953224;16964248;17047224;17290220;17303577;17314102;17443180;17496917;17562858;17636564;17644308;17702576;17873522;17980597;17981138;18079694;18172164;18178551;18195037;18414036;18467330;18570872;18632802;18635759;18636086;18997792;18997794;19015242;19135894;19188362;19241374;19278658;19289468;19363159;19398555;19416807;19424180;19426221;19524512;19524513;19535145;19815541;19838211;19874889;19910467;20005846;20096447;20185725;20219915;20228808;20300203;20304918;20368735;20385093;20385556;20483727;20501646;20651737;20888210;21081755;21091114;21235526;21239494;21362556;21408173;21447281;21571647;21596315;21659512;21737330;21849505;21931591;21962518;22029577;22085928;22095281;22128162;22179575;22216260;22265413;22297296;22421439;22435550;22817896;22848449;23159851;23313255;23395819;23453969;23486064;23667509;23746843;23824326;23825189;24056413;24059293;24098568;24246475;24248355;24260525;24298274;24316671;24323043;24366607;24432023;24493797;24703947;24714562;24726323;24726327;24813885;24896179;25152365;25197364;25305019;25565632;25578727;25852146;25892735;25996294;26344099;26728094;26775703;26866270;26900751;26933192;26997266;27307491;27458237;27545878;27552911;27591049;27846572;28506461;28661484;28832583;28904123;28920952;28920954;29242379;29642005;29681455;29769354;29883609;29883610;29930286;30146158;30361438;30420664;30770249;30988283;31031142;31138766;31217245;31358971;31366726;31511692;31844290;32269263;32320653;32350084;32561730;32983136;33469115;33717175;33912179;34162724;34363755;34876703;34999730;35051231;35154160;35941131;36284347;37243389;37406588;38130918;38443362;38876304;7531702;7544915;7578059;7639698;7667287;8521496;8548810;8552191;8643514;8663299;8702708;9049422;9065443;9122217;9247583;9367155;9430721;9718306;9744859;9852070",
        "class_list": "",
        "function": "CIAP2 mRNA mediates translation only via ribosome bypassing 62 uAUGs. Shunting efficiency was altered by stress & was facilitated by a conserved RNA folding domain (1,470 to 1,877 nucleotides upstream) in a region not scanned by shunting ribosomes., [RefSeq, PubMed]; CircNUP54 promotes hepatocellular carcinoma progression via facilitating HuR cytoplasmic export and stabilizing BIRC3 mRNA. Publication Status: Online-Only, [RefSeq, PubMed]; Identification and validation of prognostic and tumor microenvironment characteristics of necroptosis index and BIRC3 in clear cell renal cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of mutation gene prognostic biomarker in multiple myeloma through gene panel exome sequencing and transcriptome analysis in Chinese population., [RefSeq, PubMed]; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8., [UniProtKB, PubMed, PubMed]; SNHG1, a KLF4-upregulated gene, promotes glioma cell survival and tumorigenesis under endoplasmic reticulum stress by upregulating BIRC3 expression., [RefSeq, PubMed]; This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]., [RefSeq]; USP36 inhibits apoptosis by deubiquitinating cIAP1 and survivin in colorectal cancer cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 12,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16628;Q9HC27;Q9UP46",
        "ec_number_list": "3.4.19.12;2.7.11.10;2.7.11.1;2.4.1.255;2.7.11.25;2.7.10.2;2.3.2.-;3.4.25.1;2.3.2.24;2.3.2.23;2.3.2.27;3.4.22.61;2.3.2.31;2.3.2.26",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0016740 transferase activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0007283 spermatogenesis;GO:0034121 regulation of toll-like receptor signaling pathway;GO:0043066 negative regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 26.7,
        "record_id": "Q13489-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NR09-1",
        "uniprot_id": "BIRC6_HUMAN",
        "mass": 530269.0,
        "length": 4857,
        "protein_name": "Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6",
        "gene_name": "BIRC6",
        "organism": "Human",
        "refseq_name": "dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform 1",
        "refseq_ac": "NP_057336",
        "gene_names_uniprotkb": "BIRC6; KIAA1289",
        "gene_names_refseq": "APOLLON; BIRC6; BRUCE",
        "protein_names_uniprotkb": "Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6; 2.3.2.24; APOLLON; BIR repeat-containing ubiquitin-conjugating enzyme; BRUCE; Baculoviral IAP repeat-containing protein 6; Ubiquitin-conjugating BIR domain enzyme apollon",
        "protein_names_refseq": "BIR repeat-containing ubiquitin-conjugating enzyme; RING-type E3 ubiquitin transferase BIRC6; baculoviral IAP repeat-containing protein 6; dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform 1; dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6; ubiquitin-conjugating BIR-domain enzyme apollon",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57448);  (R-HSA-9700645);  (R-HSA-9725370)",
        "pathway_count": 3,
        "publication_count": 182,
        "publication_id_list": "10.1101/2023.09.13.557529;10216106;10544019;10556217;10702393;10706082;10706887;10934142;11110708;11237011;11280786;11310834;11504915;11751994;11850821;11943732;11988758;12112524;12185581;12424201;12750159;12800156;12920229;12934099;14765125;14962911;15169778;15200957;15208656;15300255;15340445;15374880;15588951;15895073;16153455;16161041;16170336;16825495;16871283;16939498;17081983;17086210;17185414;17322306;17353907;17416736;17483340;17625570;18097461;18160138;18329369;18414036;18452278;18452557;18510355;18593892;18594010;18669648;18701132;18724359;18767875;18923523;18923524;18923525;19456272;19459784;19651622;20058876;20068231;20454865;21134980;21164297;21213368;21406692;21415216;21494621;21502504;21596819;21656749;21838707;21847362;21948233;22249260;22327622;22347464;22496338;22544926;22570254;22658521;22898188;23104988;23139213;23186163;23201355;23239810;23301498;23481700;23661334;23957430;24060861;24129315;24275569;24445538;24475247;24496003;24518094;24613930;24675041;24736082;25228534;25342631;25393796;25418920;25421750;25645385;25813404;25892735;25921060;26001147;26062823;26301689;26464158;26728094;26768311;26939704;27245569;27573755;27600516;27874193;27920218;28063628;28218747;28228285;28404650;28510447;28514659;28520795;28649982;28659337;28741662;28832583;28834231;28855257;29237092;29242379;29331515;29393594;29455642;29508533;29632046;29632711;29769354;29786170;29789417;29873274;30131584;30315122;30379171;30524438;30626607;30692217;30779550;31366041;31388026;34185709;35494241;36215666;36284347;36581221;36758104;36758105;36758106;37217939;37938771;38253038;38438090;39258752;39534244;40914422;7824924;8633037;9819383",
        "class_list": "",
        "function": "Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Apollon binds to, ubiquitinates and facilitates proteasomal degradation of SMAC and caspase-9, results suggesting that Apollon has an essential function in preventing SMAC-induced apoptosis, [RefSeq, PubMed]; CircBIRC6 affects prostate cancer progression by regulating miR-574-5p and DNAJB1., [RefSeq, PubMed]; CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer., [RefSeq, PubMed]; Overexpression of Nrdp1 promotes ubiquitination and proteasomal degradation of BRUCE., [RefSeq, PubMed]; Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6., [RefSeq, PubMed]; Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex., [RefSeq, PubMed]; Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases., [RefSeq, PubMed]; This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 22,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 127,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9ULD1",
        "ec_number_list": "3.1.3.16;6.1.1.16;2.3.2.-;2.3.2.24;2.7.10.2;2.7.11.1;2.7.10.1",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004842 ubiquitin-protein transferase activity;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0061631 ubiquitin conjugating enzyme activity",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005813 centrosome",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 19.2,
        "record_id": "Q9NR09-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P30043-1",
        "uniprot_id": "BLVRB_HUMAN",
        "mass": 22119.0,
        "length": 206,
        "protein_name": "Flavin reductase (NADPH)",
        "gene_name": "BLVRB",
        "organism": "Human",
        "refseq_name": "flavin reductase (NADPH)",
        "refseq_ac": "NP_000704",
        "gene_names_uniprotkb": "BLVRB; FLR; SCAN",
        "gene_names_refseq": "BLVRB; BVRB; FLR; HEL-S-10; SDR43U1",
        "protein_names_uniprotkb": "Flavin reductase (NADPH); 1.3.1.-; 1.5.1.30; 2.6.99.-; BVR-B; Biliverdin reductase B; Biliverdin-IX beta-reductase; FLR; FR; GHBP; Green heme-binding protein; NADPH-dependent diaphorase; NADPH-flavin reductase; S-nitroso-CoA-assisted nitrosyltransferase; SNO-CoA-assisted nitrosyltransferase",
        "protein_names_refseq": "BVR-B; FR; GHBP; NADPH-dependent diaphorase; NADPH-flavin reductase; S-nitroso-CoA-assisted nitrosyltransferase; SNO-CoA-assisted nitrosyltransferase; biliverdin-IX beta-reductase; epididymis secretory protein Li 10; flavin reductase (NADPH); green heme-binding protein; short chain dehydrogenase/reductase family 43U, member 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:645);  (R-HSA-189483);  (R-HSA-9707564)",
        "pathway_count": 3,
        "publication_count": 89,
        "publication_id_list": "10421658;10620517;10644574;10858451;11023036;11134001;11224564;11237011;11397817;1157293;1286669;12969439;15001581;15245331;16568091;17264172;18241201;19651622;19690164;19968714;20068231;20929863;21209280;22232210;22427940;22823425;23186163;24275569;25576301;25645385;26992070;27207795;27600516;27846572;27893789;27897348;28228285;28698372;28832583;28904123;29242379;29487133;29500232;29557506;29786170;29932944;30573663;30779550;31154438;31611695;31844290;32157095;32161166;32162841;32246827;32350084;32357974;32387766;32938616;32983136;33298915;33592498;33912179;33968037;33981976;34019948;3427020;34357683;34509645;34725712;3475708;34957824;35051231;35580925;36284347;37371462;37645217;37938771;38056462;38665916;4980931;6094553;7372607;7929092;8117274;8280170;8313871;8687377;8799475",
        "class_list": "",
        "function": "Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Early stages of lineage fate potential require glutamine anaplerotic functions and an intact Pentose phosphate pathway, which are, in part, regulated by BLVRB activity. In principle, BLVRB inhibition represents an alternative strategy for modulating cellular glutamine utilization with consequences for cancer and hematopoietic metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent nitrosyltransferase (PubMed:10620517, PubMed:18241201, PubMed:27207795, PubMed:38056462, PubMed:7929092). Promotes fetal heme degradation during development (PubMed:10858451, PubMed:18241201, PubMed:7929092). Also expressed in adult tissues, where it acts as a regulator of hematopoiesis, intermediary metabolism (glutaminolysis, glycolysis, TCA cycle and pentose phosphate pathway) and insulin signaling (PubMed:27207795, PubMed:29500232, PubMed:38056462). Has a broad specificity oxidoreductase activity by catalyzing the NAD(P)H-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone) (PubMed:10620517, PubMed:18241201, PubMed:7929092). Contributes to fetal heme catabolism by catalyzing reduction of biliverdin IXbeta into bilirubin IXbeta in the liver (PubMed:10858451, PubMed:18241201, PubMed:7929092). Biliverdin IXbeta, which constitutes the major heme catabolite in the fetus is not present in adult (PubMed:10858451, PubMed:18241201, PubMed:7929092). Does not reduce bilirubin IXalpha (PubMed:10858451, PubMed:18241201, PubMed:7929092). Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH (PubMed:10620517). Acts as a protein nitrosyltransferase by catalyzing nitrosylation of cysteine residues of target proteins, such as HMOX2, INSR and IRS1 (PubMed:38056462). S-nitroso-CoA-dependent nitrosyltransferase activity is mediated via a 'ping-pong' mechanism: BLVRB first associates with both S-nitroso-CoA and protein substrate, nitric oxide group is then transferred from S-nitroso-CoA to Cys-109 and Cys-188 residues of BLVRB and from S-nitroso-BLVRB to the protein substrate (PubMed:38056462). Inhibits insulin signaling by mediating nitrosylation of INSR and IRS1, leading to their inhibition (PubMed:38056462)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Structure, dynamics and function of the evolutionarily changing biliverdin reductase B family., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NKD8;B2R5C6;P32078;P53005;Q32LZ2",
        "ec_number_list": "1.3.1.-;2.6.99.-;1.5.1.30;1.3.1.24",
        "go_molecular_function": "GO:0035605 peptidyl-cysteine S-nitrosylase activity;GO:0004074 biliverdin reductase [NAD(P)H] activity;GO:0042602 riboflavin reductase (NADPH) activity;GO:0052873 FMN reductase (NADPH) activity;GO:0052874 FMN reductase (NADH) activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0042167 heme catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.2,
        "record_id": "P30043-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P08949-1",
        "uniprot_id": "NMB_HUMAN",
        "mass": 13252.0,
        "length": 121,
        "protein_name": "Neuromedin-B",
        "gene_name": "NMB",
        "organism": "Human",
        "refseq_name": "neuromedin-B isoform 1 preproprotein",
        "refseq_ac": "NP_066563",
        "gene_names_uniprotkb": "NMB",
        "gene_names_refseq": "NMB",
        "protein_names_uniprotkb": "Neuromedin-B",
        "protein_names_refseq": "Neuromedin-B-32; neuromedin-B isoform 1 preproprotein; neuromedin-beta",
        "tax_id": 9606,
        "disease": "obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:4828);  (R-HSA-375276);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 135,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10544247;10567430;10604470;10727532;10854085;10861009;10899166;11015615;11322507;11385580;11457843;11562423;11683476;11742120;11753430;11773063;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15539556;1567413;15947423;15951850;16182515;16268778;16339447;1655761;16754659;16923326;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18515384;18577758;18936096;1905813;23446738;23584533;23690594;2458345;24906252;25813380;2649896;26992070;27496565;27634552;2841328;28834231;29242379;29557506;30224376;3086311;31154438;31601264;31844290;3202875;32157095;32265295;32387766;3366244;3525564;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8440682;8463333;8503909;8615752;8664309;8666380;8702752;873923;8823230;9171878;9305846;9521323;9530155;9593744;9607765;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "GPNMB is exposed on the surface of dormant breast cancer cells and its activity contributes to the acquisition of stem cell-like properties, [RefSeq, PubMed]; Genetic clues to the mechanism by which MC4R, FTO, and NMB influences changes in BMI and obesity., [RefSeq, PubMed]; Stimulates smooth muscle contraction (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 9,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96A06;Q96HH5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0031710 neuromedin B receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0043005 neuron projection",
        "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0007165 signal transduction;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0007267 cell-cell signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 14.6,
        "record_id": "P08949-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P55285-1",
        "uniprot_id": "CADH6_HUMAN",
        "mass": 88309.0,
        "length": 790,
        "protein_name": "Cadherin-6",
        "gene_name": "CDH6",
        "organism": "Human",
        "refseq_name": "cadherin-6 isoform 1 preproprotein",
        "refseq_ac": "NP_004923",
        "gene_names_uniprotkb": "CDH6",
        "gene_names_refseq": "CAD6; CDH6; KCAD",
        "protein_names_uniprotkb": "Cadherin-6; K-cadherin; Kidney cadherin",
        "protein_names_refseq": "cadherin 6, type 2, K-cadherin (fetal kidney); cadherin-6 isoform 1 preproprotein",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:1004);  (R-HSA-418990)",
        "pathway_count": 2,
        "publication_count": 30,
        "publication_id_list": "10225955;11237011;12050160;16335952;16467305;17967169;19354288;19651622;2059658;23090970;23481700;24190977;25372031;25505266;29242379;29557506;30620550;32427856;32600462;34087483;35051231;35580925;36284347;37074911;37523816;38719785;7743525;7806582;9219219;9845526",
        "class_list": "",
        "function": "CDH6 and HAGH protein levels in plasma associate with Alzheimer's disease in APOE epsilon4 carriers. Publication Status: Online-Only, [RefSeq, PubMed]; Cadherin-6 is a novel mediator for the migration of mesenchymal stem cells to glioblastoma cells in response to stromal cell-derived factor-1., [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB, UniProtKB, UniProtKB]; Characterization of the role for cadherin 6 in the regulation of human endometrial receptivity. Publication Status: Online-Only, [RefSeq, PubMed]; The GLI2/CDH6 axis enhances migration, invasion and mitochondrial fission of stomach adenocarcinoma cells., [RefSeq, PubMed]; This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 39,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 79,
        "disease_count": 2,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5H5;Q9BWS0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0030054 cell junction;GO:0016342 catenin complex",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 11.8,
        "record_id": "P55285-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q10589-1",
        "uniprot_id": "BST2_HUMAN",
        "mass": 19769.0,
        "length": 180,
        "protein_name": "Bone marrow stromal antigen 2",
        "gene_name": "BST2",
        "organism": "Human",
        "refseq_name": "bone marrow stromal antigen 2 precursor",
        "refseq_ac": "NP_004326",
        "gene_names_uniprotkb": "BST2",
        "gene_names_refseq": "BST2; CD317; HM1.24; TETHERIN",
        "protein_names_uniprotkb": "Bone marrow stromal antigen 2; BST-2; HM1.24 antigen; Tetherin",
        "protein_names_refseq": "BST-2; HM1.24 antigen; NPC-A-7; antiviral factor tetherin; bone marrow stromal antigen 2 precursor; bone marrow stromal antigen 2",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stomach cancer (Disease Ontology:DOID:10534); Sjogren's syndrome (Disease Ontology:DOID:12894); endometrial cancer (Disease Ontology:DOID:1380); malignant astrocytoma (Disease Ontology:DOID:3069); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); acquired immunodeficiency syndrome (Disease Ontology:DOID:635)",
        "pathway": " (hsa:684);  (R-HSA-6798695);  (R-HSA-909733);  (R-HSA-9692916)",
        "pathway_count": 4,
        "publication_count": 226,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10329429;10395669;10542297;10982844;11092454;11237011;11337497;11377645;11404376;11585831;12029096;12766484;12842042;14769151;15047845;15208624;15312780;15449939;15778442;16009940;16157322;16171819;16602701;16987978;17035307;17251292;17270291;1730654;17351669;17412287;17566972;17596301;17761676;17969444;18035202;18200009;18342597;18575461;19036818;19159218;19179289;19349973;19380580;19398035;19564354;19737401;19740980;19837671;19879838;19917491;20019814;20130243;20363976;20399176;20419159;20643137;20686043;20688520;20880831;20940320;20943977;21166593;21222046;21529378;21621240;21994744;22046132;22065321;2211721;22180752;22253733;22299025;22312431;22509177;22520941;22811908;23028328;23061660;23121362;23328677;23483519;23584533;23650620;23719902;24190977;24417533;24509444;24622840;24714562;24715725;24854014;25135833;25211072;25371710;25502872;25505266;25576301;25764917;25907116;26172439;26320399;26378163;26992070;27090790;27164085;27203180;27452731;27726376;27846572;27862975;27920218;28148787;28228285;28467828;28489076;28510447;28832583;28871256;28904123;29242379;29294448;29303997;29314611;29391424;29393594;29493099;29508533;29557506;29632711;29741879;29786170;30185776;30315122;30429286;30484775;30485383;30524438;30573663;30626607;31034780;31092671;31154438;31199522;31217245;31231549;31530632;31548259;31611695;31844290;31941832;32032529;32113509;32157095;32161166;32265295;32350084;32357974;32488085;32502341;32511913;32574262;32661006;32728199;32758689;32862111;32897882;32938616;32983136;33043033;33060197;33117408;33141586;33189161;33193462;33214551;33298915;33396578;33592498;33912179;33936100;33968037;34019948;34078123;34171305;34357683;34433824;34932366;35051231;35154160;35251023;35289036;35580925;36215666;36241641;37074911;37490916;37922253;38140605;38197534;38360199;38747016;40596516;6162102;6548414;688397;7510216;7526154;7537377;7540766;7607676;8197134;8232552;8605876;8621447;8692836;8702790;9096384;9121453;9242679;9334213;9660177;9847332;9861020;9989503",
        "class_list": "",
        "function": "Autophagy-related protein 5 (ATG5) interacts with bone marrow stromal cell antigen 2 (BST2) to stimulate HBV replication through antagonizing the antiviral activity of BST2., [RefSeq, PubMed]; BST2 promotes gastric cancer metastasis under the regulation of HOXD9 and PABPC1., [RefSeq, PubMed]; Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]., [RefSeq]; Human BST2 inhibits rabies virus release independently of cysteine-linked dimerization and asparagine-linked glycosylation. Publication Status: Online-Only, [RefSeq, PubMed]; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted (PubMed:18200009, PubMed:18342597, PubMed:19036818, PubMed:19879838, PubMed:20019814, PubMed:20399176, PubMed:20419159, PubMed:20940320, PubMed:21529378, PubMed:22520941, PubMed:37922253). Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, paramyxoviridae: nipah virus, and coronaviridae: SARS-CoV (PubMed:18200009, PubMed:18342597, PubMed:19179289, PubMed:19879838, PubMed:20399176, PubMed:20419159, PubMed:20686043, PubMed:20943977, PubMed:21529378, PubMed:21621240, PubMed:22520941, PubMed:26378163, PubMed:31199522). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration (PubMed:22065321). Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed:19564354, PubMed:26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed:23028328, PubMed:26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed:23028328, PubMed:26172439). Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2 (PubMed:23028328)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27-Driven Itch Pathway., [RefSeq, PubMed]; Tetherin Restricts SARS-CoV-2 despite the Presence of Multiple Viral Antagonists. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 2,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 25,
        "disease_count": 7,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4Y4;Q53G07",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008191 metalloendopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0045121 membrane raft",
        "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0030336 negative regulation of cell migration;GO:0042113 B cell activation",
        "synthesized_glycan_count": 0,
        "hit_score": 25.9,
        "record_id": "Q10589-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13410-1",
        "uniprot_id": "BT1A1_HUMAN",
        "mass": 58960.0,
        "length": 526,
        "protein_name": "Butyrophilin subfamily 1 member A1",
        "gene_name": "BTN1A1",
        "organism": "Human",
        "refseq_name": "butyrophilin subfamily 1 member A1 precursor",
        "refseq_ac": "NP_001723",
        "gene_names_uniprotkb": "BTN1A1; BTN",
        "gene_names_refseq": "BTN1A1; BTN1; BTN; BT",
        "protein_names_uniprotkb": "Butyrophilin subfamily 1 member A1; BT",
        "protein_names_refseq": "bK14H9.2 (butyrophilin, subfamily 1, member A1); butyrophilin subfamily 1 member A1 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:696);  (R-HSA-8851680)",
        "pathway_count": 2,
        "publication_count": 33,
        "publication_id_list": "12502743;16751379;17785817;18780401;19531472;20208008;20944003;21915327;23481700;24036152;24703779;24715725;25637025;25657647;25880248;26154972;26375851;28218747;28228285;29393594;29437277;29786170;30315122;31154438;32125861;32357974;32502341;32938616;33298915;34171305;37074911;38485289;8611614",
        "class_list": "",
        "function": "BTN1A1 is a novel immune checkpoint mutually exclusive to PD-L1. Publication Status: Online-Only, [RefSeq, PubMed]; Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families [provided by RefSeq, Jul 2008]., [RefSeq]; Data illustrated the importance of Akt1 in mammary epithelial cell proliferation, as well as in the regulation of Btn1a1 and subsequent expression of ss-casein., [RefSeq, PubMed]; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 831,
        "biomarker_type": "",
        "glycan_count": 44,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4VAN3;Q4VAN4;Q9H458",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "Q13410-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q4AC94-5",
        "uniprot_id": "C2CD3_HUMAN",
        "mass": 260389.0,
        "length": 2353,
        "protein_name": "C2 domain-containing protein 3",
        "gene_name": "C2CD3",
        "organism": "Human",
        "refseq_name": "C2 domain-containing protein 3 isoform 1",
        "refseq_ac": "NP_001273506",
        "gene_names_uniprotkb": "C2CD3",
        "gene_names_refseq": "C2CD3; OFD14",
        "protein_names_uniprotkb": "C2 domain-containing protein 3",
        "protein_names_refseq": "C2 calcium dependent domain containing 3; C2 domain-containing protein 3 isoform 1; C2 domain-containing protein 3",
        "tax_id": 9606,
        "disease": "orofaciodigital syndrome XIV (Disease Ontology:DOID:0060958)",
        "pathway": " (hsa:26005);  (R-HSA-5620912)",
        "pathway_count": 2,
        "publication_count": 107,
        "publication_id_list": "10.1101/2023.09.13.557529;16357211;17574030;17646400;17719545;18037885;18220336;18694559;18801063;19004860;19081074;19940019;20230748;20308558;20399632;20558667;21273506;21422230;21548880;21565611;21620453;21725307;21792235;22179047;22433857;22653444;23141531;23141541;23186163;23253480;23348840;23400999;23481700;23530209;23747070;23769972;23789104;24053599;24089205;24231678;24469809;24982133;24997988;25047611;25313408;25418920;25576301;25880248;25892735;26154972;26477546;26811146;26929215;26992070;27397612;27846572;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29557506;29632046;29632711;29769354;29786170;30097616;30258116;30315122;30379171;30429286;30524438;30988386;31844290;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34171305;34357683;34509645;34932366;35051231;35319462;35580925;36010968;36215666;36241641;37217939;38253038;40307207",
        "class_list": "",
        "function": "Biallelic C2CD3 variants lead to a broad spectrum of ciliopathy phenotypes., [RefSeq, PubMed]; CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis. Erratum:[Sci Rep. 2020 Jan 22;10(1):1265. doi: 10.1038/s41598-020-58151-y. PMID: 31965052] Publication Status: Online-Only, [RefSeq, PubMed]; Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3., [UniProtKB, PubMed, PubMed]; Evolutionary conservation of centriole rotational asymmetry in the human centrosome. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of C2CD3 results in short centrioles without subdistal and distal appendages., [RefSeq, PubMed]; Talpid3, C2CD3, and OFD1 differentially regulate the assembly of centriole sub-distal appendages, the CEP350/FOP/CEP19 module, centriolar satellites, and actin networks. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that functions as a regulator of centriole elongation. Studies of the orthologous mouse protein show that it promotes centriolar distal appendage assembly and is also required for the recruitment of other ciliogenic proteins, including intraflagellar transport proteins. Mutations in this gene cause orofaciodigital syndrome XIV (OFD14), a ciliopathy resulting in malformations of the oral cavity, face and digits. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 50,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JR55;E2QRD1;Q2NLE1;Q3C1U9;Q6ZU92;Q8IYM4;Q8NB87;Q8NDH7;Q9Y4M2",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005815 microtubule organizing center;GO:0005814 centriole;GO:0034451 centriolar satellite",
        "go_biological_process": "GO:0060271 cilium assembly;GO:1905515 non-motile cilium assembly;GO:0071539 protein localization to centrosome;GO:0061511 centriole elongation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "Q4AC94-5",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7KYR7-2",
        "uniprot_id": "BT2A1_HUMAN",
        "mass": 59633.0,
        "length": 527,
        "protein_name": "Butyrophilin subfamily 2 member A1",
        "gene_name": "BTN2A1",
        "organism": "Human",
        "refseq_name": "butyrophilin subfamily 2 member A1 isoform 3",
        "refseq_ac": "NP_001184162",
        "gene_names_uniprotkb": "BTN2A1; BT2.1; BTF1",
        "gene_names_refseq": "BK14H9.1; BT2.1; BTF1; BTN2.1; BTN2A1; DJ3E1.1",
        "protein_names_uniprotkb": "Butyrophilin subfamily 2 member A1",
        "protein_names_refseq": "butyrophilin subfamily 2 member A1 isoform 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11120);  (R-HSA-8851680)",
        "pathway_count": 2,
        "publication_count": 50,
        "publication_id_list": "10.1101/2023.09.13.557529;12502743;16751379;17785817;19349973;19531472;20208008;20944003;21211798;24036152;24190977;24703779;25637025;25657647;26992070;27600516;28228285;28832583;28834231;29242379;29393594;29557506;29632711;30315122;30429286;31844290;32157095;32161166;32350084;32357974;32387766;32897882;32938616;32983136;33298915;33912179;33968037;34019948;34260935;34357683;34509645;35051231;35081362;35251023;35833118;37171180;37217939;37674084;9149941;9382921",
        "class_list": "",
        "function": "BTN2A1 may be a susceptibility gene for myocardial infarction in Japanese individuals., [RefSeq, PubMed]; BTN2A1, an immune checkpoint targeting Vgamma9Vdelta2 T cell cytotoxicity against malignant cells., [RefSeq, PubMed]; BTN3A Targeting Vgamma9Vdelta2 T Cells Antimicrobial Activity Against Coxiella burnetii-Infected Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1., [RefSeq, PubMed]; Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vgamma9Vdelta2 T cells., [RefSeq, PubMed]; Rather than interacting with T cells, butyrophilin BTN2A1 is recognized by DC-SIGN on immature monocyte-derived dendritic cells., [RefSeq, PubMed]; The intracellular domain of BTN2A1 binds to the intracellular domain of BTN3A1 only in the presence of phosphoantigen., [RefSeq, PubMed]; This gene encodes a member of the immunoglobulin superfamily. The gene is located in a cluster of butyrophilin-like genes in the juxta-telomeric region of the major histocompatibility complex on chromosome 6. A pseudogene of this gene has been identified in this cluster. The encoded protein is an integral plasma membrane protein involved in lipid, fatty-acid, and sterol metabolism. Alterations in this gene may be associated with several disease states including metabolic syndrome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DLP9;E9PGR4;O00475;P78408;Q59EN4;Q7KYQ7;Q7Z386;Q96AV7;Q9NU62",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q7KYR7-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86YS7-1",
        "uniprot_id": "C2CD5_HUMAN",
        "mass": 110447.0,
        "length": 1000,
        "protein_name": "C2 domain-containing protein 5",
        "gene_name": "C2CD5",
        "organism": "Human",
        "refseq_name": "C2 domain-containing protein 5 isoform c",
        "refseq_ac": "NP_001273102",
        "gene_names_uniprotkb": "C2CD5; CDP138; KIAA0528",
        "gene_names_refseq": "C2CD5; CDP138; KIAA0528",
        "protein_names_uniprotkb": "C2 domain-containing protein 5; C2 domain-containing phosphoprotein of 138 kDa",
        "protein_names_refseq": "138 kDa C2 domain-containing phosphoprotein; C2 domain-containing protein 5 isoform c; C2 domain-containing protein 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9847);  (R-HSA-1445148)",
        "pathway_count": 2,
        "publication_count": 68,
        "publication_id_list": "11237011;15919790;15971998;16880201;17081983;17322306;17369524;17995453;18077418;18220336;18507432;18669648;18691976;18767875;19013499;19252894;19369195;19413330;19651622;19664994;19664995;19690332;20058876;20068231;20631154;20701589;20837646;20937701;21406692;21454505;21454690;21907143;23186163;23301498;24275569;2550440;25576301;26154972;26992070;28880265;29493099;29557506;30429286;30651536;31844290;32157095;32350084;32387766;32502341;32897882;32983136;33141586;33392160;33592498;33717175;33912179;34171305;34185709;34357683;34725712;35051231;35580925;36241641;37938771;38253038;40307207;8094051;8664345",
        "class_list": "",
        "function": "Enhanced radiosensitivity and decreased migration in cells caused by CDP138 knockdown are partially dependent on GDF15 inhibition. Erratum:[Cell Death Dis. 2024 Jul 31;15(7):549. doi: 10.1038/s41419-024-06823-2. PMID: 39085215] Publication Status: Online-Only, [RefSeq, PubMed]; Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM., [UniProtKB, PubMed]; Study finds that CDK5, 14-3-3 epsilon, and KIAA0528 are all essential for cytoplasmic dynein force adaptation and that they regulate the transport of lipid droplets, lysosomes, and mitochondria. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 33,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DJ03;B4DRN7;B7ZLL0;F5H2A1;F5H5R1;O60280;Q17RY7;Q7Z619;Q86SU3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030659 cytoplasmic vesicle membrane;GO:0032587 ruffle membrane",
        "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0008286 insulin receptor signaling pathway;GO:0031340 positive regulation of vesicle fusion;GO:0065002 intracellular protein transmembrane transport;GO:0090314 positive regulation of protein targeting to membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q86YS7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N1D0-1",
        "uniprot_id": "BWR1B_HUMAN",
        "mass": 27061.0,
        "length": 253,
        "protein_name": "Uncharacterized protein SLC67A1-AS",
        "gene_name": "SLC67A1-AS",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "SLC67A1-AS; BWR1B; BWSCR1B; ORCTL2S; SLC22A18AS; SLC22A1LS",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Uncharacterized protein SLC67A1-AS; Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene B protein; Organic cation transporter-like protein 2 antisense protein; SLC67A1 antisense RNA; Solute carrier family 22 member 1-like antisense protein; Solute carrier family 22 member 18 antisense protein; p27-BWR1B; p27-Beckwith-Wiedemann region 1 B",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 4,
        "publication_id_list": "15175115;34087483;9520460;9570947",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "predicted_o_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
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        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PLK8;O43563",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8N1D0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N3J6-1",
        "uniprot_id": "CADM2_HUMAN",
        "mass": 47554.0,
        "length": 435,
        "protein_name": "Cell adhesion molecule 2",
        "gene_name": "CADM2",
        "organism": "Human",
        "refseq_name": "cell adhesion molecule 2 isoform 1 precursor",
        "refseq_ac": "NP_001161146",
        "gene_names_uniprotkb": "CADM2; IGSF4D; NECL3",
        "gene_names_refseq": "CADM2; IGSF4D; NECL3; Necl-3; SynCAM 2; SynCAM-2; synCAM2",
        "protein_names_uniprotkb": "Cell adhesion molecule 2; IgSF4D; Immunoglobulin superfamily member 4D; NECL-3; Nectin-like protein 3; SynCAM 2; Synaptic cell adhesion molecule 2",
        "protein_names_refseq": "cell adhesion molecule 2 isoform 1 precursor; immunoglobulin superfamily member 4D; nectin-like 3; nectin-like protein 3; synaptic cell adhesion molecule 2",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); malignant astrocytoma (Disease Ontology:DOID:3069); hepatocellular carcinoma (Disease Ontology:DOID:684); retinoblastoma (Disease Ontology:DOID:768); psoriasis (Disease Ontology:DOID:8893); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:253559);  (R-HSA-418990)",
        "pathway_count": 2,
        "publication_count": 26,
        "publication_id_list": "10.1101/2023.09.13.557529;10225955;12050160;16467305;17967169;19354288;19861958;21062931;21864505;25372031;28904123;29557506;31154438;32161166;33592498;34357683;35051231;37166307;37173343;37228062;37904118;38126999;38767769;7806582;9219219;9845526",
        "class_list": "",
        "function": "(Microbial infection) Induces cell fusion in neuron infected by a neuropathogenic strain of measles. Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus., [UniProtKB, PubMed]; Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes., [UniProtKB, PubMed]; CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. Publication Status: Online-Only, [RefSeq, PubMed]; CADM2 participates in endometriosis development by influencing the epithelial-mesenchymal transition. Erratum:[Reprod Sci. 2024 Jul;31(7):2135. doi: 10.1007/s43032-024-01609-5. PMID: 38819523], [RefSeq, PubMed]; Genetic correlation for alcohol consumption between Europeans and East Asians. Publication Status: Online-Only, [RefSeq, PubMed]; Hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis., [RefSeq, PubMed]; Its expression is regulated in part by promoter methylation and implicates CADM-2 as a previously unrecognized tumor suppressor gene in a proportion of human prostate cancers., [RefSeq, PubMed]; Liver fibrosis-derived exosomal miR-106a-5p facilitates the malignancy by targeting SAMD12 and CADM2 in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Erratum:[Am J Gastroenterol. 2010 Feb;105(2):479. van der Woude, Janneke C [corrected to van der Woude, C Janneke]], [RefSeq, PubMed]; This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G3XHN7;G3XHN8;Q3KQY9;Q658Q7;Q8IZP8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0045202 synapse;GO:0032809 neuronal cell body membrane",
        "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q8N3J6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NCU7-1",
        "uniprot_id": "C2C4A_HUMAN",
        "mass": 39744.0,
        "length": 369,
        "protein_name": "C2 calcium-dependent domain-containing protein 4A",
        "gene_name": "C2CD4A",
        "organism": "Human",
        "refseq_name": "C2 calcium-dependent domain-containing protein 4A",
        "refseq_ac": "NP_997205",
        "gene_names_uniprotkb": "C2CD4A; FAM148A; NLF1",
        "gene_names_refseq": "C2CD4A; FAM148A; NLF1",
        "protein_names_uniprotkb": "C2 calcium-dependent domain-containing protein 4A; Nuclear-localized factor 1; Protein FAM148A",
        "protein_names_refseq": "C2 calcium-dependent domain-containing protein 4A; family with sequence similarity 148, member A; nuclear localized factor 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:145741)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "15527968;20818381;26154972;26621454;27329800;28005267;29625024;29786170;29789417;31154438;31527256;31844290;33912179;35051231;35212842;37938771",
        "class_list": "",
        "function": "C2CD4A expression is significantly upregulated in human masticatory mucosa during wound healing, [RefSeq, PubMed]; C2CD4A is a transcriptional coregulator of the glycolytic pathway whose dysfunction accounts for the diabetes susceptibility associated with the chromosome 15 GWAS locus., [RefSeq, PubMed]; C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population., [RefSeq, PubMed]; May be involved in inflammatory process. May regulate cell architecture and adhesion., [UniProtKB, PubMed]; NLF1 may play a role in regulating genes which control cellular architecture., [RefSeq, PubMed]; Rs7163757 contributes to genetic risk of islet dysfunction and type 2 diabetes by increasing NFAT-mediated islet enhancer activity and modulating C2CD4B, and possibly C2CD4A, expression in (patho)physiologic states., [RefSeq, PubMed]; Single nucleotide polymorphism in C2CD4A is associated with type 2 diabetes. GeneRIF: Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The present data thus provide evidence for a limited role for changes in VPS13C expression in conferring altered type 2 diabetes risk at this locus, particularly in females, and suggest that C2CD4A, but not C2CD4B, may also be involved., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus",
        "go_biological_process": "GO:0030155 regulation of cell adhesion;GO:0002675 positive regulation of acute inflammatory response;GO:0002528 regulation of vascular permeability involved in acute inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q8NCU7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TF44-1",
        "uniprot_id": "C2C4C_HUMAN",
        "mass": 44576.0,
        "length": 421,
        "protein_name": "C2 calcium-dependent domain-containing protein 4C",
        "gene_name": "C2CD4C",
        "organism": "Human",
        "refseq_name": "C2 calcium-dependent domain-containing protein 4C",
        "refseq_ac": "NP_001129735",
        "gene_names_uniprotkb": "C2CD4C; FAM148C; KIAA1957; NLF3",
        "gene_names_refseq": "C2CD4C; FAM148C; KIAA1957; NLF3",
        "protein_names_uniprotkb": "C2 calcium-dependent domain-containing protein 4C; Nuclear-localized factor 3; Protein FAM148C",
        "protein_names_refseq": "C2 calcium-dependent domain-containing protein 4C; family with sequence similarity 148, member C; nuclear-localized factor 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:126567)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "15527968;21406692;26154972;29237092;29557506;33981976;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
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        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N3H7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8TF44-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96EU7-1",
        "uniprot_id": "C1GLC_HUMAN",
        "mass": 36382.0,
        "length": 318,
        "protein_name": "C1GALT1-specific chaperone 1",
        "gene_name": "C1GALT1C1",
        "organism": "Human",
        "refseq_name": "C1GALT1-specific chaperone 1",
        "refseq_ac": "NP_001011551",
        "gene_names_uniprotkb": "C1GALT1C1; COSMC; HSPC067; MSTP143; PRO310",
        "gene_names_refseq": "AHUS8; C1GALT1C1; C1GALT2; C38H2-L1; COSMC; HSPC067; MST143; TNPS",
        "protein_names_uniprotkb": "C1GALT1-specific chaperone 1; C1Gal-T2; C1GalT2; C38H2-L1; C38H2-like protein 1; Core 1 beta1,3-galactosyltransferase 2; Core 1 beta3-Gal-T2; Core 1 beta3-galactosyltransferase-specific molecular chaperone",
        "protein_names_refseq": "C1GALT1-specific chaperone 1; C38H2-like protein 1; beta 1,3-galactosyltransferase 2; core 1 beta1,3-galactosyltransferase 2; core 1 beta3-Gal-T-specific molecular chaperone; core 1 beta3-Gal-T2; core 1 beta3-galactosyltransferase-specific molecular chaperone",
        "tax_id": 9606,
        "disease": "Tn polyagglutination syndrome (Disease Ontology:DOID:0080520); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); hemolytic uremic syndrome, atypical, 8, with rhizomelic short stature (MONDO:MONDO:0957495)",
        "pathway": " (hsa:29071);  (R-HSA-5083632);  (R-HSA-913709)",
        "pathway_count": 3,
        "publication_count": 82,
        "publication_id_list": "10330415;10430883;10753916;11042166;11283017;11304796;11821425;12361956;12464682;12855678;12975309;1329093;15486459;15560372;15620693;16251947;17038624;17113861;17228361;18061573;18537974;22183981;24643043;24714562;24715725;25576301;25892735;26728094;26758079;26992070;27862975;28218747;28514659;28832583;28904123;29242379;29393594;29437277;29557506;29769354;29786170;30315122;30410026;30429286;31154438;31217245;31471227;31611695;31633299;31844290;31848261;32161166;32186752;32387766;32938616;33141586;33298915;33392160;33912179;33968037;34087483;34171305;34185709;34357683;34509645;34644263;35051231;35154160;35251023;35561310;35580925;36241641;36599939;37216524;37938771;7655172;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "glycogene;glycosyltransferase",
        "function": "C1GALT1C1/COSMC is a novel prognostic biomarker for hepatocellular carcinoma., [RefSeq, PubMed]; Cosmc overexpression enhances malignancies in human colon cancer., [RefSeq, PubMed]; Cosmc transfection decreases malignant behavior of Tn(+) cells and enhances sensitivity to apoptosis when induced by Apo2L/TRAIL via alteration of O-glycan structure., [RefSeq, PubMed]; MicroRNA196b targets COSMC in pediatric IgA nephropathy., [RefSeq, PubMed]; Molecular cloning and characterization; C1Gal-T2 is the second candidate for core 1 synthase that plays an important role in synthesizing O-glycans in digestive organs Erratum:[J Biol Chem. 2006 Aug 25;281(34):24999], [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1)., [UniProtKB, PubMed, PubMed]; These results suggest that the intracellular dynamics of C1GalT is controlled by its specific molecular chaperon, Cosmc, in association with core 1 synthase activity., [RefSeq, PubMed]; This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2009]., [RefSeq]; Tn syndrome is associated with a somatic mutation in Cosmc, a gene on the X chromosome that encodes a molecular 'chaperone' that is required for the proper folding and hence full activity of T-synthase, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 249,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K246;Q8WWS3;Q9NZX1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006493 protein O-linked glycosylation",
        "synthesized_glycan_count": 3300,
        "hit_score": 8.3,
        "record_id": "Q96EU7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96HQ2-1",
        "uniprot_id": "C2AIL_HUMAN",
        "mass": 13196.0,
        "length": 116,
        "protein_name": "CDKN2AIP N-terminal-like protein",
        "gene_name": "CDKN2AIPNL",
        "organism": "Human",
        "refseq_name": "CDKN2AIP N-terminal-like protein",
        "refseq_ac": "NP_542387",
        "gene_names_uniprotkb": "CDKN2AIPNL",
        "gene_names_refseq": "C2AIL; CDKN2AIPNL; XTBD1",
        "protein_names_uniprotkb": "CDKN2AIP N-terminal-like protein; CDKN2A-interacting protein N-terminal-like protein",
        "protein_names_refseq": "CDKN2A interacting protein N-terminal like; CDKN2A-interacting protein N-terminal-like protein; CDKN2AIP N-terminal-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91368)",
        "pathway_count": 1,
        "publication_count": 41,
        "publication_id_list": "22645359;25576301;26024233;26154972;26779609;26992070;27600516;27920218;28063628;28832583;28834231;29242379;29393594;29493099;29557506;29632046;30379171;30410026;30429286;30833945;31217245;31530632;31844290;32157095;32265295;32387766;32488085;32897882;33298915;33592498;33633747;33968037;33981976;34019948;34561969;34932366;35051231;35318648;35580925;36241641;37938771",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WVE3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "Q96HQ2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BXI9-2",
        "uniprot_id": "C1QT6_HUMAN",
        "mass": 30861.0,
        "length": 278,
        "protein_name": "Complement C1q tumor necrosis factor-related protein 6",
        "gene_name": "C1QTNF6",
        "organism": "Human",
        "refseq_name": "complement C1q tumor necrosis factor-related protein 6 isoform 1 precursor",
        "refseq_ac": "NP_114116",
        "gene_names_uniprotkb": "C1QTNF6; CTRP6; PRO1151",
        "gene_names_refseq": "C1QTNF6; CTFP6; CTRP6; ZACRP6",
        "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 6",
        "protein_names_refseq": "C1q and tumor necrosis factor related protein 6; complement C1q tumor necrosis factor-related protein 6 isoform 1 precursor; complement C1q tumor necrosis factor-related protein 6; complement-c1q tumor necrosis factor-related protein 6",
        "tax_id": 9606,
        "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525); myocardial infarction (Disease Ontology:DOID:5844)",
        "pathway": " (hsa:114904)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "10.1101/2023.09.13.557529;12975309;15340161;19073967;29786170;30429286;31844290;34171305;35494241;36348139;38084702;38750921;38984926",
        "class_list": "",
        "function": "CTRP6 alleviates endometrial fibrosis by regulating Smad3 pathway in intrauterine adhesiondagger., [RefSeq, PubMed]; CTRP6 protects against ferroptosis to drive lung cancer progression and metastasis by destabilizing SOCS2 and augmenting the xCT/GPX4 pathway., [RefSeq, PubMed]; Down regulation of C1q tumor necrosis factor-related protein 6 is associated with increased risk of breast cancer., [RefSeq, PubMed]; MiR-29c-3p/C1QTNF6 Restrains the Angiogenesis and Cell Proliferation, Migration and Invasion in Head and Neck Squamous Cell Carcinoma., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
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        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 9848,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5H9G8;Q6ZRM7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q9BXI9-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9C0B6-1",
        "uniprot_id": "BRNP2_HUMAN",
        "mass": 89005.0,
        "length": 783,
        "protein_name": "BMP/retinoic acid-inducible neural-specific protein 2",
        "gene_name": "BRINP2",
        "organism": "Human",
        "refseq_name": "BMP/retinoic acid-inducible neural-specific protein 2 precursor",
        "refseq_ac": "NP_066988",
        "gene_names_uniprotkb": "BRINP2; DBCCR1L2; FAM5B; KIAA1747",
        "gene_names_refseq": "BRINP2; DBCCR1L2; FAM5B",
        "protein_names_uniprotkb": "BMP/retinoic acid-inducible neural-specific protein 2; DBCCR1-like protein 2",
        "protein_names_refseq": "BMP/retinoic acid-inducible neural-specific protein 2 precursor; BMP/retinoic acid-inducible neural-specific protein 2; DBCCR1-like protein 2; DBCCR1-like2; bone morphogenetic protein/retinoic acid inducible neural-specific 2; bone morphogenic protein/retinoic acid inducible neural-specific 2; family with sequence similarity 5, member B; protein FAM5B",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866)",
        "pathway": " (hsa:57795)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "24715725;29557506;31844290;32502341;33392160;33592498;33981976;35051231",
        "class_list": "",
        "function": "Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition., [UniProtKB]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 6,
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        "secondary_ac_list": "O95560;Q6ZWC1;Q7LCZ9;Q8N360",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0045666 positive regulation of neuron differentiation;GO:0071300 cellular response to retinoic acid;GO:0045930 negative regulation of mitotic cell cycle;GO:0021953 central nervous system neuron differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q9C0B6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H0C5-1",
        "uniprot_id": "BTBD1_HUMAN",
        "mass": 52771.0,
        "length": 482,
        "protein_name": "BTB/POZ domain-containing protein 1",
        "gene_name": "BTBD1",
        "organism": "Human",
        "refseq_name": "BTB/POZ domain-containing protein 1 isoform 2",
        "refseq_ac": "NP_001011885",
        "gene_names_uniprotkb": "BTBD1; C15orf1; NS5ATP8",
        "gene_names_refseq": "BTBD1; C15orf1; NS5ATP8",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein 1; HCV NS5A-transactivated protein 8; Hepatitis C virus NS5A-transactivated protein 8",
        "protein_names_refseq": "BTB (POZ) domain containing 1; BTB/POZ domain-containing protein 1 isoform 2; BTB/POZ domain-containing protein 1; HCV NS5A-transactivated protein 8; hepatitis C virus NS5A-transactivated protein 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:53339);  (R-HSA-8951664);  (R-HSA-983168)",
        "pathway_count": 3,
        "publication_count": 203,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11062501;11069780;11179693;11230166;11237011;11259415;11292861;11292862;11350924;11454738;11585840;11733065;11818025;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12646216;12682069;12759363;12816948;12878161;14528312;14690597;14734113;14757770;15224091;15224092;15282312;15361859;15367669;15537541;15571818;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16595681;16647857;16707496;16790436;16849449;16943200;16954532;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18662542;18775313;18776931;18805092;18826954;18851830;18926707;19028597;19250909;19321346;19352404;19452197;19489725;19617556;19748355;19851334;19874575;19940261;21447816;21463634;21778237;21863050;21940857;22306028;22424782;22466964;22537386;2261476;22898188;22959436;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24129315;24366543;24366607;24636985;24793695;24793696;25314029;25349211;25355947;25418920;25531226;25645385;25892735;26154972;26344709;26375851;26460955;26632597;26811146;26906416;26929215;26992070;27030794;27222660;27565346;27846572;27920218;28063628;28115426;28218747;28228285;28514659;28832583;28834231;28904123;29153394;29242379;29393594;29437277;29493099;29557506;29632046;29632711;29786170;30315122;30410026;30418433;30429286;30484775;30524438;30610225;30779550;31154438;31844290;32005965;32157095;32265295;32284348;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33444648;33537174;33592498;33691108;33717175;33912179;33936100;33968037;34087483;34171305;34405274;34509645;34932366;35051231;36010968;36215666;36228153;36241641;36284347;37938771;9380723;9668046;9790970;9887101;9891082",
        "class_list": "",
        "function": "Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB]; Subcellular colocalization of BTBD1 and BTBD2 to cytoplasmic bodies; TRIM5delta colocalized with BTBD1/2 and appeared to serve as a scaffold for the assembly of endogenous BTBD1/2 proteins, [RefSeq, PubMed]; The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NMI8;Q9BX71;Q9NWN4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0097602 cullin family protein binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007517 muscle organ development;GO:0016567 protein ubiquitination;GO:0043393 regulation of protein binding;GO:0022008 neurogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 20.4,
        "record_id": "Q9H0C5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H8M2-5",
        "uniprot_id": "BRD9_HUMAN",
        "mass": 67000.0,
        "length": 597,
        "protein_name": "Bromodomain-containing protein 9",
        "gene_name": "BRD9",
        "organism": "Human",
        "refseq_name": "bromodomain-containing protein 9 isoform 2",
        "refseq_ac": "NP_001009877",
        "gene_names_uniprotkb": "BRD9; PRO9856",
        "gene_names_refseq": "BRD9; LAVS3040; PRO9856; SMARCI2",
        "protein_names_uniprotkb": "Bromodomain-containing protein 9; Rhabdomyosarcoma antigen MU-RMS-40.8",
        "protein_names_refseq": "bromodomain-containing protein 9 isoform 2; bromodomain-containing protein 9; rhabdomyosarcoma antigen MU-RMS-40.8; sarcoma antigen NY-SAR-29",
        "tax_id": 9606,
        "disease": "alcohol use disorder (Disease Ontology:DOID:1574)",
        "pathway": " (hsa:65980);  (R-HSA-9933947)",
        "pathway_count": 2,
        "publication_count": 65,
        "publication_id_list": "12975309;17081983;19608861;19651622;19690332;20068231;21555454;22464331;23186163;23481700;24275569;24715725;25576301;25593309;25645385;25880248;25892735;26154972;26365797;26992070;27846572;28218747;28228285;28832583;28834231;28904123;29242379;29374058;29393594;29437277;29493099;29508533;29557506;29632711;29786170;30315122;30429286;31844290;32157095;32276436;32357974;32387766;32457312;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33968037;34019948;34087483;34211107;34405274;34509645;35051231;35580925;36241641;38126767;38255982;38303608;38816579;38972607",
        "class_list": "",
        "function": "BRD9 regulates normal human hematopoietic stem cell function and lineage differentiation., [RefSeq, PubMed]; Bromodomain-Containing Protein 9 Regulates Signaling Pathways and Reprograms the Epigenome in Immortalized Human Uterine Fibroid Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Pan-cancer analyses of bromodomain containing 9 as a novel therapeutic target reveals its diagnostic, prognostic potential and biological mechanism in human tumours., [RefSeq, PubMed]; Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Also orchestrates the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; TPPP-BRD9 fusion-related gallbladder carcinomas are frequently associated with intracholecystic neoplasia, neuroendocrine carcinoma, and a distinctive small tubular-type adenocarcinoma commonly accompanied with a syringomatous pattern., [RefSeq, PubMed]; The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NFY8;B4DMQ2;B4DR93;Q2XUS1;Q6UWU9;Q8IUS4;Q9H5Q5;Q9H7R9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0003676 nucleic acid binding;GO:0140566 histone reader activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0000785 chromatin;GO:0035861 site of double-strand break",
        "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q9H8M2-5",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NYX4-1",
        "uniprot_id": "CALY_HUMAN",
        "mass": 23434.0,
        "length": 217,
        "protein_name": "Neuron-specific vesicular protein calcyon",
        "gene_name": "CALY",
        "organism": "Human",
        "refseq_name": "neuron-specific vesicular protein calcyon isoform 1",
        "refseq_ac": "NP_056537",
        "gene_names_uniprotkb": "CALY; DRD1IP",
        "gene_names_refseq": "CALY; DRD1IP; NSG3",
        "protein_names_uniprotkb": "Neuron-specific vesicular protein calcyon",
        "protein_names_refseq": "D1 dopamine receptor-interacting protein; calcyon D1 dopamine receptor-interacting protein (CALCYON); calcyon protein; dopamine receptor D1 interacting protein; neuron-specific vesicular protein calcyon isoform 1; neuron-specific vesicular protein calcyon",
        "tax_id": 9606,
        "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); schizophrenia (Disease Ontology:DOID:5419)",
        "pathway": " (hsa:50632)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "10698743;12622665;14534309;14755439;16172615;16385451;16595675;17081983;19838169;20468064;20602615;21415033;22843680;23234360;25376768;35051231;35580925",
        "class_list": "",
        "function": "Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation., [RefSeq, PubMed]; CaMKII is a key effector in the Ca2+ and microtubule-dependent delivery of calcyon to the cell surface., [RefSeq, PubMed]; Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization, [RefSeq, PubMed]; Genetic variants in the CALCYON gene do not play a major role in predisposition to either schizophrenia or cocaine dependence i GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis., [UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed, PubMed]; Quantitative trait analyses of most common haplotype, designated C1, showed significant relationships with both the inattentive and hyperactive/impulsive dimensions of the disorder. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008]., [RefSeq]; This review focuses on two closely related, neuron-enriched endosomal proteins: NEEP21 and Calcyon which perform distinct roles in regulating receptor endocytosis, recycling, and degradation--{REVIEW} Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VWX3;Q5VWY5;Q5VWY6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0032051 clathrin light chain binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030659 cytoplasmic vesicle membrane",
        "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0016197 endosomal transport;GO:0048268 clathrin coat assembly;GO:0045807 positive regulation of endocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q9NYX4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P20160-1",
        "uniprot_id": "CAP7_HUMAN",
        "mass": 26886.0,
        "length": 251,
        "protein_name": "Azurocidin",
        "gene_name": "AZU1",
        "organism": "Human",
        "refseq_name": "azurocidin preproprotein",
        "refseq_ac": "NP_001691",
        "gene_names_uniprotkb": "AZU1",
        "gene_names_refseq": "AZAMP; AZU1; AZU; CAP37; HBP; HUMAZUR; NAZC; hHBP",
        "protein_names_uniprotkb": "Azurocidin; Cationic antimicrobial protein CAP37; HBP; Heparin-binding protein; hHBP",
        "protein_names_refseq": "azurocidin preproprotein; cationic antimicrobial protein 37; cationic antimicrobial protein CAP37; heparin-binding protein; neutrophil azurocidin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:566);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 36,
        "publication_id_list": "37639587;10534120;11237011;11994286;1399008;1518849;1755383;1897955;19159218;1919011;1937776;2026172;2049091;2226832;2312733;2332502;23650620;2404977;2406527;2501794;26274980;26375851;29557506;29741879;32373127;32387766;33091337;33392160;36245028;36803152;37074911;38057352;8506327;8692836;9095193;9761855",
        "class_list": "",
        "function": "AZU1 (HBP/CAP37) and PRKCG (PKC-gamma) may be candidate genes affecting the severity of acute mountain sickness. Publication Status: Online-Only, [RefSeq, PubMed]; Azurocidin 1 displays antimicrobial activity against E. coli, S. faecalis, and C. albicans., [RefSeq, PubMed]; Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015]., [RefSeq]; Increased CAP37 Expression in Stable Chronic Obstructive Pulmonary Disease., [RefSeq, PubMed]; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G., [UniProtKB, PubMed, PubMed, PubMed]; Utility of heparin-binding protein following cardiothoracic surgery using cardiopulmonary bypass. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 29,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P80014;Q52LG4;Q9UCM1;Q9UCT5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0015643 toxic substance binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0008233 peptidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0035578 azurophil granule lumen",
        "go_biological_process": "GO:0001774 microglial cell activation;GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0035556 intracellular signal transduction;GO:0042117 monocyte activation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "P20160-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BXJ0-1",
        "uniprot_id": "C1QT5_HUMAN",
        "mass": 25298.0,
        "length": 243,
        "protein_name": "Complement C1q tumor necrosis factor-related protein 5",
        "gene_name": "C1QTNF5",
        "organism": "Human",
        "refseq_name": "complement C1q tumor necrosis factor-related protein 5 precursor",
        "refseq_ac": "NP_001265360",
        "gene_names_uniprotkb": "C1QTNF5; CTRP5; PRO344",
        "gene_names_refseq": "C1QTNF5; CTRP5; MFRP",
        "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 5",
        "protein_names_refseq": "C1q TNF-alpha-related protein 5; C1q and tumor necrosis factor related protein 5; Membrane frizzled-related protein; complement C1q tumor necrosis factor-related protein 5 precursor; myonectin",
        "tax_id": 9606,
        "disease": "late-onset retinal degeneration (Disease Ontology:DOID:0060869)",
        "pathway": " (hsa:114902)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;11263980;12944416;12975309;15340161;16123441;16376663;20554618;22892318;27862975;29557506;30429286;31154438;31848261;35051231;35580925;36457269;37938771;38085246;38246238",
        "class_list": "",
        "function": "A single locus at 11q23 is implicated in a complex ocular phenotype involving RPE and CE, tissues of neuroectodermal origin., [RefSeq, PubMed]; C1QTNF5 is a novel attachment factor that facilitates the entry of influenza A virus., [RefSeq, PubMed]; CTRP5 has a role in extracellular deposit formation in late-onset retinal degeneration, [RefSeq, PubMed]; Cloning of the bicistronic transcript and characterization of the upstream ORF, MFRP, [RefSeq, PubMed]; In this family with a proven mutation in this gene, peripupillary iris atrophy and abnormally long anterior zonular insertions were present before retinal changes and visual loss., [RefSeq, PubMed]; Longitudinal Changes of Retinal Structure in Molecularly Confirmed C1QTNF5 Patients With Late-Onset Retinal Degeneration., [RefSeq, PubMed]; This gene encodes a member of a family of proteins that function as components of basement membranes and may play a role in cell adhesion. Mutations in this gene have been associated with late-onset retinal degeneration. The protein may be encoded by either a bicistronic transcript including sequence from the upstream membrane frizzled-related protein gene (MFRP), or by a monocistronic transcript expressed from an internal promoter. [provided by RefSeq, Jun 2013]., [RefSeq]; This study revealed the presence of a functional promoter for the CTRP5 gene located 5' of its start site., [RefSeq, PubMed]; Upregulation of IL-8, osteonectin, and myonectin mRNAs by intermittent hypoxia via OCT1- and NRF2-mediated mechanisms in skeletal muscle cells., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NDD3;B0YJ35;Q335M2;Q8N6P2;Q9UFX4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016324 apical plasma membrane;GO:0030133 transport vesicle",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q9BXJ0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q4G0S4-2",
        "uniprot_id": "C27C1_HUMAN",
        "mass": 60920.0,
        "length": 542,
        "protein_name": "Cytochrome P450 27C1",
        "gene_name": "CYP27C1",
        "organism": "Human",
        "refseq_name": "cytochrome P450 27C1 isoform 1",
        "refseq_ac": "NP_001001665",
        "gene_names_uniprotkb": "CYP27C1",
        "gene_names_refseq": "CYP27C1",
        "protein_names_uniprotkb": "Cytochrome P450 27C1; 1.14.19.53; All-trans retinol 3,4-desaturase",
        "protein_names_refseq": "all-trans retinol 3,4-desaturase; cytochrome P450 27C1 isoform 1; cytochrome P450 27C1; cytochrome P450, family 27, subfamily C, polypeptide 13",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:339761)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "12477932;16360114;27059013;28701464;33968037;35887201",
        "class_list": "",
        "function": "A cytochrome P450 monooxygenase that catalyzes the 3,4 desaturation of all-trans-retinol (also called vitamin A1) to all-trans-3,4-didehydroretinol (also called vitamin A2) in the skin. Desaturates with lower efficiency all-trans retinal and all-trans retinoic acid. Forms minor amounts of 3-hydroxy and 4-hydroxy all-trans-retinol derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin)., [UniProtKB, PubMed, PubMed]; Cytochrome P450 27C1 Level Dictates Lung Cancer Tumorigenicity and Sensitivity towards Multiple Anticancer Agents and Its Potential Interplay with the IGF-1R/Akt/p53 Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that the most likely catalytic mechanism for conversion of all-trans-retinol to 3,4-dehydroretinol by CYP27C1 begins with abstraction of a hydrogen atom from C-4 (or possibly C-3) initiating desaturation pathway, followed by sequential abstraction of a hydrogen atom or proton-coupled electron transfer. CYP27C1 appears to be localized to skin., [RefSeq, PubMed]; This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A590UJ17;Q6ZNI7",
        "ec_number_list": "1.14.19.53",
        "go_molecular_function": "GO:0005506 iron ion binding;GO:0005503 all-trans retinal binding;GO:0020037 heme binding;GO:0001972 retinoic acid binding;GO:0004497 monooxygenase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane",
        "go_biological_process": "GO:0042572 retinol metabolic process;GO:0042573 retinoic acid metabolic process;GO:0042574 retinal metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q4G0S4-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P1N0-1",
        "uniprot_id": "C2D1A_HUMAN",
        "mass": 104062.0,
        "length": 951,
        "protein_name": "Coiled-coil and C2 domain-containing protein 1A",
        "gene_name": "CC2D1A",
        "organism": "Human",
        "refseq_name": "coiled-coil and C2 domain-containing protein 1A isoform 1",
        "refseq_ac": "NP_060191",
        "gene_names_uniprotkb": "CC2D1A; AKI1; LGD2",
        "gene_names_refseq": "Aki-1; CC2D1A; FREUD-1; Freud-1/Aki1; Lgd2; MRT3; TAPE",
        "protein_names_uniprotkb": "Coiled-coil and C2 domain-containing protein 1A; Akt kinase-interacting protein 1; FRE under dual repression-binding protein 1; Five prime repressor element under dual repression-binding protein 1; Freud-1; Putative NF-kappa-B-activating protein 023N",
        "protein_names_refseq": "Akt kinase-interacting protein 1; FRE under dual repression-binding protein 1; TBK1-associated protein in endolysosomes; coiled-coil and C2 domain-containing protein 1A isoform 1; coiled-coil and C2 domain-containing protein 1A; five prime repressor element under dual repression-binding protein 1; five repressor element under dual repression-binding protein 1; lethal (2) giant discs homolog 2; putative NF-kappa-B-activating protein 023N; putative NFkB activating protein",
        "tax_id": 9606,
        "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); syndromic intellectual disability (Disease Ontology:DOID:0050888); ciliopathy (Disease Ontology:DOID:0060340); autosomal recessive intellectual developmental disorder 3 (Disease Ontology:DOID:0081179); intellectual disability (Disease Ontology:DOID:1059)",
        "pathway": " (hsa:54862)",
        "pathway_count": 1,
        "publication_count": 64,
        "publication_id_list": "11237011;12761501;14756806;15534042;15592455;16033914;16964243;17714190;18220336;18452278;18491316;18669648;19651622;20068231;20112406;20171170;21406692;23186163;23301498;24275569;25418920;26154972;26375851;26811146;26992070;27397612;27846572;28228285;28649982;28904123;29242379;29393594;29493099;29557506;30484775;31217245;31844290;32157095;32350084;32357974;32387766;32502341;32897882;32938616;33141586;33298915;33592498;33912179;33936100;33968037;34087483;34357683;35008409;35051231;35132862;35154160;35580925;36010968;36215666;36241641;36273889;36284347;39168639;39302247",
        "class_list": "",
        "function": "A protein truncating mutation was identified in the gene CC2D1A in nine consanguineous families with severe autosomal recessive mental retardation., [RefSeq, PubMed]; CC2D1A causes ciliopathy, intellectual disability, heterotaxy, renal dysplasia, and abnormal CSF flow. Publication Status: Online-Only, [RefSeq, PubMed]; Disruption of transcriptional regulation by mutation of Freud-1 may play a role in abnormal brain function leading to mental retardation, [RefSeq, PubMed]; Effects of the Cc2d1a/Freud-1 Knockdown in the Hippocampus of BTBR Mice on the Autistic-Like Behavior, Expression of Serotonin 5-HT1A and D2 Dopamine Receptors, and CREB and NF-kB Intracellular Signaling., [RefSeq, PubMed]; Freud-1 mediates HDAC-independent repression of the 5-HT1A receptor promoter in neuronal 5-HT1A-positive cells., [RefSeq, PubMed]; Review of Freud-1 as a repressor of serotonin 1A receptor gene. Review article, [RefSeq, PubMed]; This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in a nonsyndromic form of cognitive disability (MRT3). [provided by RefSeq, Jul 2017]., [RefSeq]; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis., [UniProtKB, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z435;Q86XV0;Q8NF89;Q9H603;Q9NXI1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0045296 cadherin binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:1905381 negative regulation of snRNA transcription by RNA polymerase II;GO:0150052 regulation of postsynapse assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "Q6P1N0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86Y37-1",
        "uniprot_id": "CACL1_HUMAN",
        "mass": 41064.0,
        "length": 369,
        "protein_name": "CDK2-associated and cullin domain-containing protein 1",
        "gene_name": "CACUL1",
        "organism": "Human",
        "refseq_name": "CDK2-associated and cullin domain-containing protein 1",
        "refseq_ac": "NP_722517",
        "gene_names_uniprotkb": "CACUL1; C10orf46; CAC1",
        "gene_names_refseq": "C10orf46; CAC1; CACUL1",
        "protein_names_uniprotkb": "CDK2-associated and cullin domain-containing protein 1; Cdk-associated cullin 1",
        "protein_names_refseq": "CDK2-associated and cullin domain-containing protein 1; Cdk-Associated Cullin1; cdk-associated cullin 1; cullin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:143384)",
        "pathway_count": 1,
        "publication_count": 54,
        "publication_id_list": "19829063;22415352;22903020;22982681;23481700;24714562;25880248;26728094;26992070;27846572;27862975;27889610;28649982;28832583;28834231;28904123;29237092;29242379;29351928;29557506;29786170;30429286;30833945;31154438;31373491;31492838;31504073;31844290;32157095;32357974;32387766;32897882;32938616;32983136;33592498;33968037;33981976;34080964;34087483;34171305;34357683;35051231;35132862;35254053;35513511;35580925;35705054;36010968;36284347;36898988;39531497;39534244;40307207;40596516",
        "class_list": "",
        "function": "CAC1 is a novel cell cycle associated protein capable of promoting cell proliferation., [RefSeq, PubMed]; CAC1 is a novel corepressor of RARalpha that cooperates with HDACs and is involved in the regulation of RA-induced cellular differentiation., [RefSeq, PubMed]; CAC1 is an important factor for the protection of cells against amyloid beta toxicity and oxidative stress in Alzheimer's disease., [RefSeq, PubMed]; CAC1 plays an important role in the occurrence and promotion of antineoplastic drug resistance in colorectal cancer. CAC1 knockdown resulted in decreased P-glycoprotein and MRP-1 protein expression. Publication Status: Online-Only, [RefSeq, PubMed]; CDK-associated Cullin 1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Human Glioblastoma., [RefSeq, PubMed]; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition., [UniProtKB, PubMed]; MiR-199a-5p can regulate CAC1 and function as a tumor suppressor in colorectal cancer., [RefSeq, PubMed]; The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei. Publication Status: Online-Only, [RefSeq, PubMed]; These data suggest that CACUL1 is a novel regulator that negatively controls p53 activity through the regulation of PML SUMOylation., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5XPL7;Q8IY11;Q8N7S4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding",
        "go_cellular_component": "",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0045860 positive regulation of protein kinase activity;GO:0000082 G1/S transition of mitotic cell cycle;GO:0006511 ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q86Y37-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NAE3-1",
        "uniprot_id": "CA180_HUMAN",
        "mass": 13125.0,
        "length": 123,
        "protein_name": "Putative uncharacterized protein encoded by LINC01555",
        "gene_name": "LINC01555",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "LINC01555; C1orf180",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein encoded by LINC01555",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "31844290",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q8NAE3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NFZ8-1",
        "uniprot_id": "CADM4_HUMAN",
        "mass": 42785.0,
        "length": 388,
        "protein_name": "Cell adhesion molecule 4",
        "gene_name": "CADM4",
        "organism": "Human",
        "refseq_name": "cell adhesion molecule 4 precursor",
        "refseq_ac": "NP_660339",
        "gene_names_uniprotkb": "CADM4; IGSF4C; NECL4; TSLL2",
        "gene_names_refseq": "CADM4; IGSF4C; NECL4; Necl-4; TSLL2; synCAM4",
        "protein_names_uniprotkb": "Cell adhesion molecule 4; IgSF4C; Immunoglobulin superfamily member 4C; NECL-4; Nectin-like protein 4; TSLC1-like protein 2",
        "protein_names_refseq": "TSLC1-like 2; TSLC1-like protein 2; cell adhesion molecule 4 precursor; immunoglobulin superfamily member 4C; nectin-like 4; nectin-like protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:199731)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "10.1101/2023.09.13.557529;11536053;16261159;18510355;19565570;20200953;21544807;23090970;24190977;28561015;28601637;28921546;29393594;29557506;29741879;29786170;30779550;31844290;32157095;32325280;33968037;33981976;34725712;37074911;39894887",
        "class_list": "",
        "function": "CADM4, as well as 4.1B is expressed specifically in human proximal tubules., [RefSeq, PubMed]; Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer., [RefSeq, PubMed]; Cell adhesion molecule, exhibiting calcium- and magnesium-independent cell-cell adhesion activity (PubMed:16261159). In its palmitoylated form, is required for proper oligodendrocyte maturation and myelination in CNS via its association with other cell adhesion molecules such as CADM2/3 and MAG (By similarity). May have tumor-suppressor activity (PubMed:16261159)., [UniProtKB, UniProtKB, PubMed]; Low CADM4 expression is associated with bone marrow metastasis in neuroblastoma., [RefSeq, PubMed]; Nec- 4 suppress the growth and tumorigenic ability of colon cancer cells., [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; TSLL2 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate, and is a tumor-suppressor candidate in prostate cancer., [RefSeq, PubMed]; The results suggest that Necl-4 enhances VEGF-induced activation of PLCgamma-c-Raf-MEK-ERK pathway without affecting the phosphorylation and internalization of VEGFR2., [RefSeq, PubMed]; There was a significant association between RNase 5 and histological differentiation in colon adenocarcinomas, but no association between RNase 5 and Necl 4 in gastric or colon adenocarcinomas Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 34,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7L5;Q9Y4A4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0043183 vascular endothelial growth factor receptor 1 binding;GO:0030971 receptor tyrosine kinase binding;GO:0019903 protein phosphatase binding;GO:0043184 vascular endothelial growth factor receptor 2 binding",
        "go_cellular_component": "GO:0016020 membrane;GO:0031252 cell leading edge;GO:0044291 cell-cell contact zone",
        "go_biological_process": "GO:0061041 regulation of wound healing;GO:0042127 regulation of cell population proliferation;GO:2000145 regulation of cell motility;GO:0001933 negative regulation of protein phosphorylation;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q8NFZ8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UJ99-1",
        "uniprot_id": "CAD22_HUMAN",
        "mass": 89091.0,
        "length": 828,
        "protein_name": "Cadherin-22",
        "gene_name": "CDH22",
        "organism": "Human",
        "refseq_name": "cadherin-22 precursor",
        "refseq_ac": "NP_067071",
        "gene_names_uniprotkb": "CDH22; C20orf25",
        "gene_names_refseq": "C20orf25; CDH22; dJ998H6.1",
        "protein_names_uniprotkb": "Cadherin-22; PB-cadherin; Pituitary and brain cadherin",
        "protein_names_refseq": "cadherin 22, type 2; cadherin-22 precursor; cadherin-like 22; ortholog of rat PB-cadherin; pituitary and brain cadherin",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:64405)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "18602983;19440036;19546606;20650312;23481700;25505266;28149335;28991229;32938616;34105348;35051231;8626716",
        "class_list": "",
        "function": "Cadherin-22 is upregulated in hypoxia via mTORC1-independent translational control by the initiation factor eIF4E2 functioning as a hypoxia-specific cell-surface molecule involved in cancer cell migration, invasion and adhesion., [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity)., [UniProtKB]; Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Our results reveal for the first time a new role of CDH22 in progression of colorectal cancer., [RefSeq, PubMed]; PRL-3 promoted downregulation of CDH22 expression., [RefSeq, PubMed]; Results present evidence that CDH22 is hypermethylated and its expression is downregulated in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the cadherin superfamily. The gene product is composed of five cadherin repeat domains and a cytoplasmic tail similar to the highly conserved cytoplasmic region of classical cadherins. Expressed predominantly in the brain, this putative calcium-dependent cell adhesion protein may play an important role in morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine organs. [provided by RefSeq, Jul 2008]., [RefSeq]; This paper deals primarily with the rat ortholog of the human CDH22 gene., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
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        "total_reported_s_glycosites": 0,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9EGK7;O43205",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding",
        "go_cellular_component": "GO:0005912 adherens junction;GO:0016342 catenin complex",
        "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q9UJ99-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y6Q1-1",
        "uniprot_id": "CAN6_HUMAN",
        "mass": 74576.0,
        "length": 641,
        "protein_name": "Calpain-6",
        "gene_name": "CAPN6",
        "organism": "Human",
        "refseq_name": "calpain-6",
        "refseq_ac": "NP_055104",
        "gene_names_uniprotkb": "CAPN6; CALPM; CANPX",
        "gene_names_refseq": "CANPX; CAPN6; CAPNX; CalpM; DJ914P14.1",
        "protein_names_uniprotkb": "Calpain-6; CalpM; Calpain-like protease X-linked; Calpamodulin",
        "protein_names_refseq": "calpain-6; calpain-like protease X-linked; calpamodulin",
        "tax_id": 9606,
        "disease": "hypertension (Disease Ontology:DOID:10763)",
        "pathway": " (hsa:827);  (R-HSA-1474228)",
        "pathway_count": 2,
        "publication_count": 74,
        "publication_id_list": "10229672;10386589;10706100;10809722;10986281;11375993;11872628;12727852;12843408;14973287;15234972;15591058;15958533;16133547;1649600;16631740;16825321;16959974;1698775;1707285;17210638;17332331;17354228;17608959;18434311;18658137;19010778;19571574;19657146;19714641;20142769;21030783;21297635;21441952;21670566;21784848;21864727;22159414;23035980;23845380;25418920;25880248;25892735;28228285;29393594;29557506;29769354;29786170;31154438;31217245;31844290;31848261;32265295;32357974;32852077;32938616;32983136;33298915;34185709;34357683;35051231;35580925;36153320;37243758;7075587;7547873;8226919;8626565;9065415;9115292;9148753;9339374;9461298;9852107",
        "class_list": "",
        "function": "A calpain-6/YAP axis in sarcoma stem cells that drives the outgrowth of tumors and metastases. Publication Status: Online-Only, [RefSeq, PubMed]; Advanced glycation end products promote the progression of chronic kidney diseases by targeting calpain 6., [RefSeq, PubMed]; Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]., [RefSeq]; Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity)., [UniProtKB, PubMed]; The investigation of calpain in human placenta with fetal growth restriction., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
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        "reported_mutagensis": 0,
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        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DUY7;Q9UEQ1;Q9UJA8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005876 spindle microtubule",
        "go_biological_process": "GO:0051493 regulation of cytoskeleton organization;GO:0001578 microtubule bundle formation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q9Y6Q1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A075B6X7-1",
        "uniprot_id": "A0A075B6X7_HUMAN",
        "mass": 2121.0,
        "length": 20,
        "protein_name": "T cell receptor alpha joining 50",
        "gene_name": "TRAJ50",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRAJ50",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor alpha joining 50",
        "protein_names_refseq": "",
        "tax_id": 9606,
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        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
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        "predicted_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A0A075B6X7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A087WWA1-1",
        "uniprot_id": "P3URF_HUMAN",
        "mass": 10952.0,
        "length": 95,
        "protein_name": "PIK3R3 upstream open reading frame protein",
        "gene_name": "P3R3URF",
        "organism": "Human",
        "refseq_name": "P3R3URF protein",
        "refseq_ac": "NP_001315584",
        "gene_names_uniprotkb": "P3R3URF",
        "gene_names_refseq": "P3R3URF",
        "protein_names_uniprotkb": "PIK3R3 upstream open reading frame protein",
        "protein_names_refseq": "P3R3URF protein; PIK3R3 upstream reading frame",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:110117498)",
        "pathway_count": 1,
        "publication_count": 0,
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        "class_list": "",
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        "predicted_glycosites": 0,
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        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "disease_count": 0,
        "glyco_site_count": 0,
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        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0019221 cytokine-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A0A087WWA1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0B4J1U6-1",
        "uniprot_id": "TVB9_HUMAN",
        "mass": 12608.0,
        "length": 114,
        "protein_name": "T cell receptor beta variable 9",
        "gene_name": "TRBV9",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRBV9",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor beta variable 9",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "15040585;20452950;23524462;24600447;25493333",
        "class_list": "",
        "function": "V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_phosphosites": 0,
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        "reported_snv": 2,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "glyco_site_count": 1,
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        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0042101 T cell receptor complex",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A0B4J1U6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0B4J245-1",
        "uniprot_id": "TVAL1_HUMAN",
        "mass": 12865.0,
        "length": 112,
        "protein_name": "T cell receptor alpha variable 12-1",
        "gene_name": "TRAV12-1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRAV12-1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor alpha variable 12-1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
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        "publication_id_list": "15040585;20452950;23524462;24600447;25493333",
        "class_list": "",
        "function": "V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
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        "mined_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042605 peptide antigen binding",
        "go_cellular_component": "GO:0042101 T cell receptor complex",
        "go_biological_process": "GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A0B4J245-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0C4DH27-1",
        "uniprot_id": "TRGV8_HUMAN",
        "mass": 13335.0,
        "length": 118,
        "protein_name": "T cell receptor gamma variable 8",
        "gene_name": "TRGV8",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRGV8; TCRGV8",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor gamma variable 8",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "23348415;24387714;24600447;25674089;28920588;32938616",
        "class_list": "",
        "function": "V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0042101 T cell receptor complex",
        "go_biological_process": "GO:0045087 innate immune response;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "A0A0C4DH27-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P30050-1",
        "uniprot_id": "RL12_HUMAN",
        "mass": 17819.0,
        "length": 165,
        "protein_name": "Large ribosomal subunit protein uL11",
        "gene_name": "RPL12",
        "organism": "Human",
        "refseq_name": "large ribosomal subunit protein uL11",
        "refseq_ac": "NP_000967",
        "gene_names_uniprotkb": "RPL12",
        "gene_names_refseq": "L12; RPL12; uL11",
        "protein_names_uniprotkb": "Large ribosomal subunit protein uL11; 60S ribosomal protein L12",
        "protein_names_refseq": "60S ribosomal protein L12; large ribosomal subunit protein uL11",
        "tax_id": 9606,
        "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)",
        "pathway": " (hsa:6136);  (R-HSA-156827);  (R-HSA-156902);  (R-HSA-1799339);  (R-HSA-192823);  (R-HSA-2408557);  (R-HSA-6791226);  (R-HSA-72689);  (R-HSA-72706);  (R-HSA-72764);  (R-HSA-9010553);  (R-HSA-9633012);  (R-HSA-975956);  (R-HSA-975957);  (R-HSA-9954709);  (R-HSA-9954714);  (R-HSA-9954716)",
        "pathway_count": 17,
        "publication_count": 270,
        "publication_id_list": "10358005;10659855;1095581;10970870;10982836;11018020;11018027;11265756;11331269;11532962;11544179;11546874;11551508;11677247;11691921;11726970;11922599;11964406;12068309;12150911;12417715;12493757;12554878;12588972;12718880;12832468;12853463;1400365;14527413;14567916;14630918;14636577;14654843;14742663;14973490;15034551;15317934;15385533;15534230;15546618;15592455;15721257;15775988;15781252;15821744;16026328;16037817;16043514;16186820;16209946;16284618;16452507;16469117;16601204;16622410;16630668;16738141;16964243;16989641;17053788;17142313;17189298;17267404;17322306;17352659;17353269;17363904;17412707;17726049;17803942;17893241;18065403;18066079;18166647;18212344;18230761;18256688;18285520;18423202;18438418;18447580;18447585;18455985;18524595;18539146;1856230;1861871;18657639;18669648;18691976;18847512;18974281;19060897;19106111;19150429;19332556;19359157;19413330;19415658;19417104;19478851;19503078;19556969;19564402;19608861;19608919;19651622;19664994;19664995;19691289;19706539;19801658;19859661;19909264;20023408;20038530;20056613;20058876;2006156;20068230;20068231;20361218;20444697;20479275;20531386;20691628;20798176;20805244;20817927;20819938;20930030;21029861;21036871;21063389;21097556;21145460;21406692;21419344;21740066;22072790;22121020;22190735;22195017;22916032;23085078;23186163;23217742;23234702;23269699;23439679;23481700;23482395;23636399;23685075;23746841;2388630;24275569;24366607;24424021;24524803;24550520;24715725;25132172;25242263;25525153;25576301;25578875;25901680;25969445;26237581;26375851;26758079;27168400;27526673;27846572;27920218;28065601;28132843;28218747;28228285;28685749;28832583;28904123;29242379;29314611;29393594;29413899;29557506;29632312;29632711;29786170;30192525;30220558;30244831;30293783;30315122;30429286;30484775;30524438;30804176;31011209;31217245;31530632;31611695;31844290;31848261;31998317;32099016;32119511;32157095;32161166;32387766;32488085;32502341;32579943;32938616;32983136;33043033;33141586;33214551;33298915;33406423;33592498;33691108;33909987;33912179;33936100;33968037;34019948;34087483;34171305;34357683;34509645;34561969;34725712;34932366;35051231;35083852;35138101;35154160;35561310;35580925;36010968;36215666;36241641;36284347;36302773;36638793;37217939;37676773;37938771;38665916;40914422;429297;592398;592399;641056;6568109;6901506;7990965;8336711;8407925;8441690;8890909;9211906;9431993;9482744;9631292;9637248;9712840",
        "class_list": "",
        "function": "Component of the large ribosomal subunit (PubMed:25901680). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:25901680). Binds directly to 26S ribosomal RNA (PubMed:25901680)., [UniProtKB, PubMed]; Phosphoproteomics on the fractions reveals that phosphorylation of serine 38 in RPL12/uL11, a known mitotic CDK1 substrate, is strongly depleted in polysomes., [RefSeq, PubMed]; RPL12 role in CFTR protein folding and stability Erratum:[PLoS Biol. 2016 Nov 2;14(11):e1002574. doi: 10.1371/journal.pbio.1002574. PMID: 27806038] Publication Status: Online-Only, [RefSeq, PubMed]; Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
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        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VVV2;Q6PB27",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0014069 postsynaptic density;GO:0016020 membrane",
        "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006412 translation;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation",
        "synthesized_glycan_count": 0,
        "hit_score": 27.3,
        "record_id": "P30050-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P49840-1",
        "uniprot_id": "GSK3A_HUMAN",
        "mass": 50981.0,
        "length": 483,
        "protein_name": "Glycogen synthase kinase-3 alpha",
        "gene_name": "GSK3A",
        "organism": "Human",
        "refseq_name": "glycogen synthase kinase-3 alpha",
        "refseq_ac": "NP_063937",
        "gene_names_uniprotkb": "GSK3A",
        "gene_names_refseq": "GSK3A",
        "protein_names_uniprotkb": "Glycogen synthase kinase-3 alpha; 2.7.11.1; 2.7.11.26; GSK-3 alpha; Serine/threonine-protein kinase GSK3A",
        "protein_names_refseq": "GSK-3 alpha; glycogen synthase kinase-3 alpha; serine/threonine-protein kinase GSK3A",
        "tax_id": 9606,
        "disease": "Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)",
        "pathway": " (hsa:2931);  (R-HSA-198323);  (R-HSA-381038);  (R-HSA-5674400);  (R-HSA-9635465);  (R-HSA-9683610);  (R-HSA-9694631)",
        "pathway_count": 7,
        "publication_count": 163,
        "publication_id_list": "10102273;10358075;10485710;10490848;10601334;10827079;10868943;11035810;11231573;11237011;11274386;11504915;11577096;11583116;11715018;11749387;11884598;12054501;12150915;12172553;12204115;12244303;12524439;12668767;12761548;12767043;14617782;15169778;15178423;15183529;15466936;15527798;15592455;15848177;16103198;16272144;16461360;16539657;16543730;16803855;16987514;17148450;17192257;17229088;17344846;17389395;17478001;17611497;18088087;18256540;18452278;18664523;18669648;18691976;18701488;18767875;18846110;18954143;19106108;19366350;19369195;19413330;19415658;19507191;19644473;19664994;19706605;19911376;20068231;20080974;20440266;20454556;20489726;20841359;21282569;22025163;22275911;22539723;23142783;24029068;24035907;24521712;25187516;25576301;25645385;25780035;25897075;26183061;26598975;26992070;27698396;27846572;27920218;28218747;28514659;28657654;28832583;28904123;29199039;29242379;29393594;29557506;29632046;30704899;31154438;31530632;31844290;31848261;32029454;32119511;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32637943;32645325;32723359;32817937;32877642;32938750;32983136;33248025;33298915;33592498;33912179;33936100;33968037;33997890;34019948;34029587;34087483;34185709;34357683;34561969;34593624;34725712;35051231;35138101;35154160;35251023;35580925;36284347;37656238;37686063;38665916;38946682;39174053;39302247;40596516;7590364;8666242;9037597;9346240;9381178;9450183;9473480;9478990;9812896;9829964;9895304",
        "class_list": "",
        "function": "Cardiac fibroblast GSK-3alpha aggravates ischemic cardiac injury by promoting fibrosis, inflammation, and impairing angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions which activates KAT5/TIP60 acetyltransferase activity and promotes acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; GSK3: A potential target and pending issues for treatment of Alzheimer's disease. Review article, [RefSeq, PubMed]; GSK3alpha Regulates Temporally Dynamic Changes in Ribosomal Proteins upon Amino Acid Starvation in Cancer Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Targeting Gsk3a reverses immune evasion to enhance immunotherapy in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 31,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O14959",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0048156 tau protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0030424 axon",
        "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0019082 viral protein processing;GO:0007399 nervous system development;GO:0010628 positive regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 16.8,
        "record_id": "P49840-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P00748-1",
        "uniprot_id": "FA12_HUMAN",
        "mass": 67792.0,
        "length": 615,
        "protein_name": "Coagulation factor XII",
        "gene_name": "F12",
        "organism": "Human",
        "refseq_name": "coagulation factor XII preproprotein",
        "refseq_ac": "NP_000496",
        "gene_names_uniprotkb": "F12",
        "gene_names_refseq": "F12; HAE3; HAEX; HAF",
        "protein_names_uniprotkb": "Coagulation factor XII; 3.4.21.38; Beta-factor XIIa part 2; HAF; Hageman factor",
        "protein_names_refseq": "Hageman factor; Plasma coagulation Factor XIIa; beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XII preproprotein; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain",
        "tax_id": 9606,
        "disease": "stroke (Disease Ontology:DOID:0051061); hereditary angioedema type III (Disease Ontology:DOID:0080940); acquired angioedema (Disease Ontology:DOID:0080941); hereditary angioedema (Disease Ontology:DOID:14735); angioedema (Disease Ontology:DOID:1558); factor XII deficiency (Disease Ontology:DOID:2231); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); myocardial infarction (Disease Ontology:DOID:5844); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:2161);  (R-HSA-9657688);  (R-HSA-9657689);  (R-HSA-9855719);  (R-HSA-9935598);  (R-HSA-9936900);  (R-HSA-9970672)",
        "pathway_count": 7,
        "publication_count": 107,
        "publication_id_list": "10.1021/acs.analchem.6b02887;10361128;1066663;10984376;11204562;11237011;11776307;11830581;11986212;12773530;12944405;1451784;14635117;14691562;14760718;15205584;1544894;15617741;15711755;16169873;16335952;16638441;17186468;17645545;19178938;19372376;1998667;2019570;2026621;21304106;21544310;21683246;2296585;23090970;23385745;2365061;24552232;2510163;2563376;2578463;2579948;26248961;27130860;27862975;28035807;28228285;28514659;2882793;28832583;2888762;29343682;29391424;29519898;29557506;29741879;29753808;29920929;3011063;30315122;30394658;30398465;30459171;30591525;3099750;31844290;33397811;33912179;33968037;34502392;3484703;34932366;35460690;35561310;35580925;36241641;36972937;37074911;37102287;3754331;3756141;38065013;3877053;3886654;39261453;4054110;4178758;4703226;500690;588558;6203908;6604055;7391081;7814636;7852321;8049433;8195709;8427954;8528215;8529136;8710908;874082;8755917;8798678;893417;9226169;9354665;9427705",
        "class_list": "",
        "function": "Factor XII Deficiency in Mexico: High Prevalence in the General Population and Patients with Venous Thromboembolic Disease., [RefSeq, PubMed]; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Factor XII signaling via uPAR-integrin beta1 axis promotes tubular senescence in diabetic kidney disease. Erratum:[Nat Commun. 2026 Jan 14;17(1):540. doi: 10.1038/s41467-026-68442-z. PMID: 41535290] Publication Status: Online-Only, [RefSeq, PubMed]; Includes the study of a polymorphic upstream ORF in this gene, and shows that it functions to reduce protein levels by ~50%., [RefSeq, PubMed]; This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]., [RefSeq]; [Analysis of F12 gene variants and molecular mechanisms in patients with coagulation factor deficiency]., [RefSeq, PubMed]; [Genetic analysis of a Chinese pedigree affected with Congenital coagulation factor XII deficiency due to a c.1A>G start codon variant of F12 gene]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 7,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 13,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 13,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 27,
        "disease_count": 11,
        "glyco_site_count": 16,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P78339",
        "ec_number_list": "3.4.21.5;3.4.21.38;3.4.21.27;3.4.21.34",
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0051787 misfolded protein binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005791 rough endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0007597 blood coagulation, intrinsic pathway;GO:0016485 protein processing;GO:0045087 innate immune response;GO:0007596 blood coagulation",
        "synthesized_glycan_count": 0,
        "hit_score": 15.1,
        "record_id": "P00748-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92558-1",
        "uniprot_id": "WASF1_HUMAN",
        "mass": 61652.0,
        "length": 559,
        "protein_name": "Actin-binding protein WASF1",
        "gene_name": "WASF1",
        "organism": "Human",
        "refseq_name": "actin-binding protein WASF1",
        "refseq_ac": "NP_001020105",
        "gene_names_uniprotkb": "WASF1; KIAA0269; SCAR1; WAVE1",
        "gene_names_refseq": "NEDALVS; SCAR1; WASF1; WAVE-1; WAVE1; WAVE",
        "protein_names_uniprotkb": "Actin-binding protein WASF1; Protein WAVE-1; Verprolin homology domain-containing protein 1; WASP family protein member 1; Wiskott-Aldrich syndrome protein family member 1",
        "protein_names_refseq": "WAS protein family member 1; WASP family protein member 1; actin-binding protein WASF1; homology of dictyostelium scar 1; protein WAVE-1; verprolin homology domain-containing protein 1; wiskott-Aldrich syndrome protein family member 1",
        "tax_id": 9606,
        "disease": "neurodevelopmental disorder with absent language and variable seizures (MONDO:MONDO:0032876)",
        "pathway": " (hsa:8936);  (R-HSA-2029482);  (R-HSA-4420097);  (R-HSA-5663213);  (R-HSA-9013149);  (R-HSA-9013423);  (R-HSA-9664422)",
        "pathway_count": 7,
        "publication_count": 360,
        "publication_id_list": "10037737;10075701;10207622;10219243;10232922;10395673;10464238;10490598;10496324;10508610;10523665;10523675;10526156;10559246;10559936;10579713;10618392;10677529;10692392;10699171;10699464;10724160;10744763;10749680;10781580;10873802;10878810;10958683;10995437;11007481;11058585;11085924;11130076;11149925;11157975;11231582;11237011;11276226;11278486;11329366;11340081;11373293;11396949;11431473;11432776;11553796;11584276;11672528;11695992;11696015;11704860;11707441;11747816;11756552;11773441;11803464;11804587;11804589;11804590;11829459;11854399;11884391;11912491;11956649;11961559;12055636;12071859;12093360;12096337;12105426;12134158;12189515;12195014;12213210;12214271;12215529;12221096;12235133;12351724;12391143;12432077;12464388;12531887;12546821;12547822;12650940;12660731;12665586;12743368;12810700;12820653;12857875;12877655;12923183;1314888;14512443;14514689;1464587;14675773;14676198;14718541;14724572;15023524;15026417;15033976;15040784;15064355;15107133;15133129;15147912;15247219;15302923;15308668;15339924;15342493;15452139;15485661;15507211;15579468;15601624;15611138;15657136;15688067;15695828;15728722;15850391;15858067;15897194;15962004;16002401;16112081;16116428;16184169;16243036;16262445;16317717;16336962;16473593;16492808;16507994;16519628;16546099;16636067;16641196;16702231;16760434;16762923;16777452;16777849;16862120;16862148;16880808;16896804;16914516;16966330;16968698;17030947;17077126;17145773;17188549;17196961;17199126;17202194;17214551;17237347;17244649;17293873;17308335;17583407;17599059;17686471;17702745;17765681;17804252;17976533;18006505;18045877;18070890;18218625;18249095;18347018;18391171;18396277;18426980;18559503;18653540;18697831;18838382;19230644;19267251;19269969;19494238;19534724;19605563;19673492;19713215;19741094;19934221;19955216;20068231;20400958;20403076;20460433;20658524;20679435;20810653;21037092;21107423;21148482;21419341;21445309;21542010;21565175;21613211;21730051;21865595;21989057;22004470;22096251;22298643;22327215;22407364;22475431;22608513;22689825;22734669;22970203;23186163;23209303;23216836;23255595;23288169;23301498;23434736;23572525;23675550;23707487;23718289;23940355;24086303;24259668;24335996;24352656;2474607;24859002;24933155;24960694;25024229;25211221;25428919;25704760;25721503;25795300;25862245;26129894;26529257;26628301;26887924;26992070;27117132;27145964;27216196;27481945;27555588;27566826;27713499;27806292;27920218;28114311;28196833;28218747;28228285;28356423;28855257;28904123;29089502;29358323;29382922;29508533;29961568;30315122;30429286;30532555;30853411;31844290;31848261;31871319;32161166;32203420;32357974;32387766;32488085;32502341;32886101;32938616;33298915;33558065;33912179;33968037;34171305;34357683;35051231;35494241;35561310;35580925;36010968;7479768;7509446;7512369;7559638;7673236;7721814;7753201;7835339;7848918;8021274;8107774;8537347;8543060;8617235;8643598;8645157;8662891;8756646;8769096;8798539;8805223;8809042;8810315;8816443;8939998;8986718;8990121;8994827;9013646;9099726;9113980;9182576;9252344;9305890;9393975;9398617;9438849;9472046;9490638;9497316;9582072;9600938;9659915;9670022;9705280;9732292;9792683;9799231;9822598;9843499;9883880;9885284;9889097;9988689",
        "class_list": "",
        "function": "Adherens junction regulates cryptic lamellipodia formation for epithelial cell migration., [RefSeq, PubMed]; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568)., [UniProtKB, UniProtKB, PubMed, PubMed]; LncRNA PVT1 promotes the malignant progression of acute myeloid leukaemia via sponging miR-29 family to increase WAVE1 expression., [RefSeq, PubMed]; The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
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        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "monitoring",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P5F2;Q5SZK7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0051018 protein kinase A binding;GO:0071933 Arp2/3 complex binding",
        "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton",
        "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0030036 actin cytoskeleton organization;GO:0016601 Rac protein signal transduction;GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 36.3,
        "record_id": "Q92558-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6PIF2-1",
        "uniprot_id": "SYCE2_HUMAN",
        "mass": 24690.0,
        "length": 218,
        "protein_name": "Synaptonemal complex central element protein 2",
        "gene_name": "SYCE2",
        "organism": "Human",
        "refseq_name": "synaptonemal complex central element protein 2",
        "refseq_ac": "NP_001099048",
        "gene_names_uniprotkb": "SYCE2; CESC1",
        "gene_names_refseq": "CESC1; SYCE2",
        "protein_names_uniprotkb": "Synaptonemal complex central element protein 2; Central element synaptonemal complex protein 1",
        "protein_names_refseq": "synaptonemal complex central element protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:256126);  (R-HSA-1221632)",
        "pathway_count": 2,
        "publication_count": 15,
        "publication_id_list": "11237011;11673449;15125634;15235794;19146767;19913121;20628086;20634189;32357974;33298915;34373646;35051231;8794855;9008167;9285814",
        "class_list": "",
        "function": "Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity)., [UniProtKB, UniProtKB]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12., [RefSeq, PubMed]; The protein encoded by this gene is part of the synaptonemal complex formed between homologous chromosomes during meiotic prophase. The encoded protein associates with SYCP1 and SYCE1 and is found only where chromosome cores are synapsed. [provided by RefSeq, Dec 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
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        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DYD3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000801 central element;GO:0000794 condensed nuclear chromosome;GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0000795 synaptonemal complex",
        "go_biological_process": "GO:0051301 cell division;GO:0007130 synaptonemal complex assembly;GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination;GO:0035825 homologous recombination",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q6PIF2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0B4J2B8-1",
        "uniprot_id": "A0A0B4J2B8_HUMAN",
        "mass": 12954.0,
        "length": 117,
        "protein_name": "Immunoglobulin heavy variable 1/OR15-9 (non-functional)",
        "gene_name": "IGHV1OR15-9",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGHV1OR15-9",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy variable 1/OR15-9 (non-functional)",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
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        "reported_snv": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "A0A0B4J2B8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A075B6W3-1",
        "uniprot_id": "A0A075B6W3_HUMAN",
        "mass": 2129.0,
        "length": 19,
        "protein_name": "T cell receptor alpha joining 33",
        "gene_name": "TRAJ33",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRAJ33",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor alpha joining 33",
        "protein_names_refseq": "",
        "tax_id": 9606,
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        "publication_count": 1,
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        "reported_n_glycosites_with_glycan": 0,
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        "biomarker_type": "",
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        "record_id": "A0A075B6W3-1",
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    },
    {
        "uniprot_canonical_ac": "A0A0A0MT96-1",
        "uniprot_id": "A0A0A0MT96_HUMAN",
        "mass": 1421.0,
        "length": 13,
        "protein_name": "Immunoglobulin kappa joining 3",
        "gene_name": "IGKJ3",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "IGKJ3",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin kappa joining 3",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
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        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
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    },
    {
        "uniprot_canonical_ac": "A0A0A6YYG3-1",
        "uniprot_id": "TVB68_HUMAN",
        "mass": 12321.0,
        "length": 113,
        "protein_name": "T cell receptor beta variable 6-8",
        "gene_name": "TRBV6-8",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "TRBV6-8",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor beta variable 6-8",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 5,
        "publication_id_list": "15040585;20452950;23524462;24600447;25493333",
        "class_list": "",
        "function": "V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
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        "total_reported_n_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0042101 T cell receptor complex",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0002250 adaptive immune response;GO:0002376 immune system process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A0A0A6YYG3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A1B0GTW7-1",
        "uniprot_id": "CIROP_HUMAN",
        "mass": 85397.0,
        "length": 788,
        "protein_name": "Ciliated left-right organizer metallopeptidase",
        "gene_name": "CIROP",
        "organism": "Human",
        "refseq_name": "ciliated left-right organizer metallopeptidase isoform 1 precursor",
        "refseq_ac": "NP_001341569",
        "gene_names_uniprotkb": "CIROP; LMLN2",
        "gene_names_refseq": "CIROP; HTX12; LMLN2",
        "protein_names_uniprotkb": "Ciliated left-right organizer metallopeptidase; 3.4.24.-; Leishmanolysin-like peptidase 2",
        "protein_names_refseq": "ciliated left-right organizer metallopeptidase isoform 1 precursor; leishmanolysin homolog; leishmanolysin like peptidase 2",
        "tax_id": 9606,
        "disease": "visceral heterotaxy 12 (Disease Ontology:DOID:0051026)",
        "pathway": " (hsa:100128908)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;33981976;34087483;34903892;35051231;35580925",
        "class_list": "",
        "function": "Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Erratum:[Nat Genet. 2022 Jun;54(6):906. doi: 10.1038/s41588-022-01053-8. PMID: 35304595], [RefSeq, PubMed]; Putative metalloproteinase that plays a role in left-right patterning process., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
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        "secondary_ac_list": "A0A2R8Y3T5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008233 peptidase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0061966 establishment of left/right asymmetry",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "A0A1B0GTW7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A1B0GWH6-1",
        "uniprot_id": "LSP1N_HUMAN",
        "mass": 2949.0,
        "length": 25,
        "protein_name": "LASP1 neighbor protein",
        "gene_name": "LASP1NB",
        "organism": "Human",
        "refseq_name": "LASP1 neighbor protein",
        "refseq_ac": "NP_001401626",
        "gene_names_uniprotkb": "LASP1NB; LINC00672",
        "gene_names_refseq": "LASP1NB; LINC00672",
        "protein_names_uniprotkb": "LASP1 neighbor protein; Long intergenic non-protein coding RNA 672",
        "protein_names_refseq": "LASP1 neighbor protein; long intergenic non-protein coding RNA 672",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100505576)",
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        "publication_count": 2,
        "publication_id_list": "28232485;31410210",
        "class_list": "",
        "function": "May play a key role in the skin fibroblasts (FBs)-keratinocyte-like cells (KLCs)., [UniProtKB, PubMed]; These findings indicate that LINC00672 can influence LASP1 expression as a locus-restricted cofactor for p53-mediated gene suppression, thus impacting endometrial cancer and chemosensitivity to paclitaxel., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
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        "hit_score": 0.3,
        "record_id": "A0A1B0GWH6-1",
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    },
    {
        "uniprot_canonical_ac": "Q6A163-1",
        "uniprot_id": "K1C39_HUMAN",
        "mass": 55651.0,
        "length": 491,
        "protein_name": "Keratin, type I cytoskeletal 39",
        "gene_name": "KRT39",
        "organism": "Human",
        "refseq_name": "keratin, type I cytoskeletal 39",
        "refseq_ac": "NP_998821",
        "gene_names_uniprotkb": "KRT39; KA35",
        "gene_names_refseq": "CK-39; K39; KA35; KRT39",
        "protein_names_uniprotkb": "Keratin, type I cytoskeletal 39; CK-39; Cytokeratin-39; K39; Keratin-39; Type I hair keratin Ka35",
        "protein_names_refseq": "cytokeratin-39; keratin 39, type I; keratin, type I cytoskeletal 39; type I hair keratin Ka35",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:390792);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 3,
        "publication_count": 55,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11237011;11350120;11380615;11590230;12902340;15033990;15085952;15337775;15373777;15617563;15797384;15803139;16061697;16382671;16639001;1691188;1694855;1714783;17301834;17515931;17521629;17562024;17596512;18843291;19190773;19194479;20179351;20657595;20667819;20940292;21439340;21654840;21997417;23481192;23629652;2414304;25208914;25926655;26390218;28411811;29393594;29557506;35051231;7543090;8824274;8999895;9395522;9468612;9565599",
        "class_list": "",
        "function": "KRT39 and KRT40 expression patterns complete sequential expression of the 16 hair keratins in the human hair follicle, [RefSeq, PubMed]; May play a role in late hair differentiation., [UniProtKB]; This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "secondary_ac_list": "B2RXK6;Q6IFU6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030280 structural constituent of skin epidermis;GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0045095 keratin filament;GO:0005882 intermediate filament",
        "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "Q6A163-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NUL3-1",
        "uniprot_id": "STAU2_HUMAN",
        "mass": 62608.0,
        "length": 570,
        "protein_name": "Double-stranded RNA-binding protein Staufen homolog 2",
        "gene_name": "STAU2",
        "organism": "Human",
        "refseq_name": "double-stranded RNA-binding protein Staufen homolog 2 isoform c",
        "refseq_ac": "NP_001157854",
        "gene_names_uniprotkb": "STAU2",
        "gene_names_refseq": "39K2; 39K3; STAU2",
        "protein_names_uniprotkb": "Double-stranded RNA-binding protein Staufen homolog 2",
        "protein_names_refseq": "double-stranded RNA-binding protein Staufen homolog 2 isoform c; double-stranded RNA-binding protein Staufen homolog 2; staufen homolog 2; staufen, RNA binding protein, homolog 2",
        "tax_id": 9606,
        "disease": "microphthalmia (Disease Ontology:DOID:10629)",
        "pathway": " (hsa:27067)",
        "pathway_count": 1,
        "publication_count": 78,
        "publication_id_list": "10.1101/2023.09.13.557529;10585778;11237011;12140260;16964243;18094122;18220336;18669648;18691976;19029303;19690332;20068231;21406692;23125361;23186163;23301498;23481700;25576301;26375851;26728094;27600516;27920218;28228285;28514659;28657654;28832583;28834231;29242379;29393594;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30484775;31217245;31844290;32157095;32350084;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33663378;33717175;33912179;33968037;34019948;34171305;34509645;34561969;34932366;34960728;35051231;35132862;35251023;35254053;35561310;35580925;36241641;36284347;36643863;37340703;37439148;37938771;39302247;40136647;40307207;40596516;41350704",
        "class_list": "",
        "function": "Data show that Stau2 is localized to the neuronal soma and dendrites, but it does not colocalize with Stau1-containing particles., [RefSeq, PubMed]; Encapsidation of Staufen-2 Enhances Infectivity of HIV-1. Publication Status: Online-Only, [RefSeq, PubMed]; Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RNF216 affects the stability of STAU2 in the hypothalamus., [RefSeq, PubMed]; STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells. Publication Status: Online-Only, [RefSeq, PubMed]; Stau1- and Stau2-mRNPs associate with distinct but overlapping sets of cellular mRNAs., [RefSeq, PubMed]; Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]., [RefSeq]",
        "predicted_glycosites": 1,
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        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 6,
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        "total_n_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
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        "reported_snv": 25,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 8,
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        "secondary_ac_list": "A0A0A0MTC5;B7Z1I6;B7Z292;B7Z8B4;E7ER74;E9PEI3;E9PF26;E9PF50;Q6AHY7;Q96HM0;Q96HM1;Q9NVI5;Q9UGG6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0051019 mitogen-activated protein kinase binding;GO:0003725 double-stranded RNA binding;GO:0019894 kinesin binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol",
        "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0034599 cellular response to oxidative stress;GO:0051965 positive regulation of synapse assembly;GO:0007281 germ cell development;GO:0051489 regulation of filopodium assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "Q9NUL3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14188-1",
        "uniprot_id": "TFDP2_HUMAN",
        "mass": 49236.0,
        "length": 446,
        "protein_name": "Transcription factor Dp-2",
        "gene_name": "TFDP2",
        "organism": "Human",
        "refseq_name": "transcription factor Dp-2 isoform 1",
        "refseq_ac": "NP_001171609",
        "gene_names_uniprotkb": "TFDP2; DP2",
        "gene_names_refseq": "DP2; TFDP2",
        "protein_names_uniprotkb": "Transcription factor Dp-2; E2F dimerization partner 2",
        "protein_names_refseq": "transcription factor Dp-2 (E2F dimerization partner 2); transcription factor Dp-2 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7029);  (R-HSA-111448);  (R-HSA-113501);  (R-HSA-1362277);  (R-HSA-1362300);  (R-HSA-139915);  (R-HSA-1538133);  (R-HSA-1912408);  (R-HSA-2173796);  (R-HSA-2559580);  (R-HSA-2559585);  (R-HSA-6804114);  (R-HSA-69202);  (R-HSA-69205);  (R-HSA-69231);  (R-HSA-69656);  (R-HSA-8953750);  (R-HSA-9616222);  (R-HSA-9661069)",
        "pathway_count": 19,
        "publication_count": 364,
        "publication_id_list": "10022869;10090723;10199400;10207050;10228158;10233885;10323868;10330422;10347217;10358095;10375532;10385618;10454565;10454584;10499802;10524633;10597240;10692433;10722742;10772813;10807576;10831586;10871633;11003670;11007770;11013220;11032757;11073976;11157749;11171983;11231573;11231585;11234019;11237011;11242107;11274402;11340171;11369759;11416152;11424093;11427533;11463392;11564866;11572983;11574543;11585773;11684017;11719808;11782450;11867521;11883935;11884610;11907280;11959842;11988738;12004135;12134156;12150994;12189133;12193592;12242300;12421820;12435631;12435635;12444543;12446674;12702500;12730199;12782299;12808055;12869508;12909625;12917425;1312467;13130464;1396589;1423597;14507994;14517214;14517297;14527418;14532106;14597415;14657019;14684737;14729966;14729977;14766746;14990995;14991602;15014447;15100235;15150273;15186775;15287722;15469821;15472075;15510213;15536069;15563468;15572696;15574328;15579463;15684396;15866172;16186825;16195327;16211008;16278212;16319104;16337592;16360038;16436515;16582612;16612405;16751774;16772293;16782892;16826196;17001316;17063141;17092340;17172876;17210787;17254966;17254967;17254968;17255097;17332741;17344414;17344417;17395714;17438144;17531812;17540598;17540599;17554337;17562868;17600109;17685488;17699597;17719541;17765224;17823410;17825402;17875933;17908796;17991896;1826560;1828392;1828393;1828394;1831692;18365017;18414028;18562691;18568018;18676979;18710949;18776924;18793328;18827403;19075005;19150886;19451217;19451218;19458076;19462008;19487459;19528227;19661920;19714243;19723635;19773441;19896182;19914168;20080834;20090754;20107323;20176812;20351093;20442293;20442780;20460379;20495621;20534573;20595680;20661648;20663872;20801121;20805998;20843055;20952511;21280156;21402699;21423214;21471526;21498570;21551231;21596310;21602795;21715330;21875955;21986495;21993314;22020331;22110129;22275377;22325352;22336108;22371011;22474248;22683641;23001182;23007395;23186163;23365256;23481700;23485469;23622515;23737759;23954429;24096481;24379003;24397554;24515438;24584857;24627085;24876129;2524830;25418920;25576301;25645385;25733683;25784653;26154972;26375851;26811146;26977885;26992070;2721961;27846572;27920218;28063628;28218747;28228285;28832583;28834231;28904123;29101237;29242379;29393594;29431622;29437277;29493099;29508533;29557506;29632046;30524438;30711375;31530632;31543423;31844290;31848261;31936902;32157095;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33912179;33936100;33968037;34087483;34171305;34211107;34932366;35318648;35561310;35580925;36010968;7535770;7588608;7588633;7623816;7629134;7739537;7743995;7784053;7784094;7797074;7799941;7816143;7859739;7862113;7929342;7954814;7973727;8001816;8050359;8078588;8114698;8114739;8139570;8246996;8259215;8288595;8319905;8336704;8413249;8497257;8552081;8618861;8622669;8622688;8626550;8695841;8700224;8741839;8755520;8774846;8846784;8846917;8878478;8943353;8974401;9020173;9030721;9042862;9106657;9144196;9162092;9177240;9190208;9195981;9199292;9325318;9342358;9447971;9448290;9482921;9501179;9508775;9520412;9529249;9564042;9628874;9632134;9659898;9662327;9689056;9693032;9704927;9724731;9768359;9778043;9824166;9891042",
        "class_list": "",
        "function": "Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812)., [UniProtKB, PubMed]; The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]., [RefSeq]; This study demonstrates translation from an internal methionine., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z8C8;B7Z8L5;D3DNG1;E9PFC3;F8WAI2;Q13331;Q14187;Q6R754;Q8WU88;Q9UG28",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0019904 protein domain specific binding;GO:0008134 transcription factor binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 36.5,
        "record_id": "Q14188-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96HY7-1",
        "uniprot_id": "DHTK1_HUMAN",
        "mass": 103077.0,
        "length": 919,
        "protein_name": "2-oxoadipate dehydrogenase complex component E1",
        "gene_name": "DHTKD1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DHTKD1; KIAA1630",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "2-oxoadipate dehydrogenase complex component E1; 1.2.4.-; 2-oxoadipate dehydrogenase, mitochondrial; Alpha-KADH-E1; Alpha-ketoadipate dehydrogenase; Dehydrogenase E1 and transketolase domain-containing protein 1; E1a; OADC-E1; OADH-E1; Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "Charcot-Marie-Tooth disease axonal type 2Q (Disease Ontology:DOID:0110170); 2-aminoadipic 2-oxoadipic aciduria (Disease Ontology:DOID:0111453)",
        "pathway": " (hsa:55526);  (R-HSA-9858328)",
        "pathway_count": 2,
        "publication_count": 31,
        "publication_id_list": "11237011;15946682;20068231;23141293;23141294;25860818;26141459;27846572;29191460;29242379;29508533;29557506;29752936;30833945;30929736;31844290;32157095;32303640;32350084;32357974;32387766;32488085;32502341;32633484;32695416;32938616;33912179;33936100;34357683;35051231;35052424",
        "class_list": "",
        "function": "2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC) (PubMed:29191460, PubMed:29752936, PubMed:32303640, PubMed:32633484, PubMed:32695416). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC (PubMed:29191460, PubMed:32695416). Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (Probable) (PubMed:29752936, PubMed:32303640, PubMed:32633484). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate (PubMed:29191460, PubMed:29752936, PubMed:32633484, PubMed:32695416). Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; 2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate. Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q68CU5;Q9BUM8;Q9HCE2",
        "ec_number_list": "1.8.1.4;2.3.1.61;1.2.4.-",
        "go_molecular_function": "GO:0030976 thiamine pyrophosphate binding;GO:0160166 2-oxoadipate dehydrogenase activity;GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0160167 oxoadipate dehydrogenase complex",
        "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0006096 glycolytic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q96HY7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y6V7-1",
        "uniprot_id": "DDX49_HUMAN",
        "mass": 54226.0,
        "length": 483,
        "protein_name": "Probable ATP-dependent RNA helicase DDX49",
        "gene_name": "DDX49",
        "organism": "Human",
        "refseq_name": "probable ATP-dependent RNA helicase DDX49",
        "refseq_ac": "NP_061943",
        "gene_names_uniprotkb": "DDX49",
        "gene_names_refseq": "DDX49; Dbp8; R27090_2",
        "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX49; 3.6.4.13; DEAD box protein 49",
        "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 49; DEAD box protein 49; probable ATP-dependent RNA helicase DDX49",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54555);  (R-HSA-6790901);  (R-HSA-6791226)",
        "pathway_count": 3,
        "publication_count": 124,
        "publication_id_list": "10606270;11081632;11237011;11922599;11935223;11978965;12068309;12150911;12417735;15199136;16037817;16043514;16381836;16738141;16782898;17189298;17353269;17412707;17636026;18065403;18438418;18446792;19033376;19106111;19332556;19463982;19564402;19748539;19801658;20038530;20047967;20056613;20531386;20798176;20805244;20819938;21036871;21063389;21097556;22072790;22190735;22195017;22916032;23391857;23439679;23482395;2388630;24086612;24424021;24550520;24714562;24715725;25411247;25525153;25576301;25645385;25653167;25851604;25969445;26085946;26154972;26196125;26237581;26728094;26992070;27084949;27600516;27846572;28063628;28228285;28832583;28904123;29242379;29393594;29557506;29618122;29632046;29786170;30192525;30315122;30484775;30524438;30779550;31092671;31217245;31749282;31844290;31937595;32157095;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33952717;33968037;33981976;34087483;34171305;34357683;34509645;34561969;34932366;35051231;35318648;36010968;36215666;36241641;36298642;37094865;37106339;9211966;9482744;9512526",
        "class_list": "",
        "function": "ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including the regulation of mRNA export and the levels of pre-ribosomal RNA. Regulates the stability and synthesis of pre-ribosomal RNA and thereby regulates cell proliferation (PubMed:29618122). Also possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (PubMed:36298642)., [UniProtKB, PubMed, PubMed]; DDX49 Promotes Proliferation and Metastasis of Cervical Cancer by Regulation of AKT and Wnt/beta-Catenin Signalings., [RefSeq, PubMed]; DDX49 displays a robust ATPase and RNA helicase activity and it is involved in the export of poly (A)+ mRNAs to cytoplasm. DDX49 is localized in the nucleolus and regulates the steady state levels of pre-ribosomal 47S RNA and global translation., [RefSeq, PubMed]; DDX49 is a novel biomarker and therapeutic target for lung cancer metastases., [RefSeq, PubMed]; DExD/H Box Helicases DDX24 and DDX49 Inhibit Reactivation of Kaposi's Sarcoma Associated Herpesvirus by Interacting with Viral mRNAs. Publication Status: Online-Only, [RefSeq, PubMed]; Morphine may act via DDX49 to inhibit hepatocellular carcinoma cell growth., [RefSeq, PubMed]; Overexpression of DDX49 in prostate cancer is associated with poor prognosis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E7ENA0;Q53FJ1;Q9BVQ8",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;2.1.1.-;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;3.1.13.-;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus",
        "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0006364 rRNA processing;GO:0044357 regulation of rRNA stability",
        "synthesized_glycan_count": 0,
        "hit_score": 12.5,
        "record_id": "Q9Y6V7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60315-1",
        "uniprot_id": "ZEB2_HUMAN",
        "mass": 136447.0,
        "length": 1214,
        "protein_name": "Zinc finger E-box-binding homeobox 2",
        "gene_name": "ZEB2",
        "organism": "Human",
        "refseq_name": "zinc finger E-box-binding homeobox 2 isoform 2",
        "refseq_ac": "NP_001165124",
        "gene_names_uniprotkb": "ZEB2; HRIHFB2411; KIAA0569; SIP1; ZFHX1B; ZFX1B",
        "gene_names_refseq": "HSPC082; SIP-1; SIP1; SMADIP1; ZEB2; ZFHX1B",
        "protein_names_uniprotkb": "Zinc finger E-box-binding homeobox 2; SMADIP1; Smad-interacting protein 1; Zinc finger homeobox protein 1b",
        "protein_names_refseq": "SMAD interacting protein 1; Smad-interacting protein 1; zinc finger E-box-binding homeobox 2 isoform 2; zinc finger homeobox 1b",
        "tax_id": 9606,
        "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); Mowat-Wilson syndrome (Disease Ontology:DOID:0060485); Hirschsprung's disease (Disease Ontology:DOID:10487); T-cell adult acute lymphocytic leukemia (Disease Ontology:DOID:5602); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844)",
        "pathway": " (hsa:9839);  (R-HSA-9762293);  (R-HSA-9764725);  (R-HSA-9764790);  (R-HSA-9823739);  (R-HSA-9832991)",
        "pathway_count": 6,
        "publication_count": 99,
        "publication_id_list": "10655587;11237011;11279515;11430829;11448942;11912130;12451214;12700765;15384097;15542832;15699330;16061479;16688751;16793922;16959974;17130829;19413330;19608861;19651622;20074535;20418909;20516212;20871592;22158034;22227038;23186163;23466526;24130169;24714562;24810778;25218447;25576301;25645385;25728771;25772364;25892735;26154972;26212009;26992070;27052315;27600516;27846572;27862975;27869121;28649982;28832583;28834231;28904123;29242379;29269046;29296180;29393594;29493099;29557506;29642003;29729076;29769354;29786170;30192525;30206221;30429286;30524438;30542730;30898548;31154438;31844290;31848261;31957176;32157095;32357974;32387766;32463580;32488085;32502341;32897882;32938616;32983136;33592498;33608512;33912179;33968037;34185709;34509645;34561969;35008676;35051231;35138000;35292107;35580925;35851744;36010968;36284347;36420658;37938771;38485033;38525813;38610009;39059495;9853615",
        "class_list": "",
        "function": "ABCs begin with ZEB2., [RefSeq, PubMed]; Circ-10720 as a ceRNA adsorbs microRNA-1238 and modulates ZEB2 to boost NSCLC development by activating EMT. Publication Status: Online-Only, [RefSeq, PubMed]; Conditional expression of SIP1 in E-cadherin-positive cells abrogates E-cadherin-mediated intercellular adhesion and induces invasion. SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors., [RefSeq, PubMed]; N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA., [RefSeq, PubMed]; The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]., [RefSeq]; Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212)., [UniProtKB, PubMed, PubMed]; Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. Represses expression of MEOX2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; ZEB2 alleviates Hirschsprung's-associated enterocolitis by promoting the proliferation and differentiation of enteric neural precursor cells via the Notch-1/Jagged-2 pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 6,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0JP09;B7Z2P2;F5H814;Q9UED1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0005694 chromosome",
        "go_biological_process": "GO:0010764 negative regulation of fibroblast migration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 10.0,
        "record_id": "O60315-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5J8M3-1",
        "uniprot_id": "EMC4_HUMAN",
        "mass": 20087.0,
        "length": 183,
        "protein_name": "ER membrane protein complex subunit 4",
        "gene_name": "EMC4",
        "organism": "Human",
        "refseq_name": "ER membrane protein complex subunit 4 isoform b",
        "refseq_ac": "NP_001273349",
        "gene_names_uniprotkb": "EMC4; HSPC184; PIG17; TMEM85",
        "gene_names_refseq": "EMC4; PIG17; TMEM85",
        "protein_names_uniprotkb": "ER membrane protein complex subunit 4; Cell proliferation-inducing gene 17 protein; Transmembrane protein 85",
        "protein_names_refseq": "ER membrane protein complex subunit 4 isoform b; cell proliferation-inducing gene 17 protein; transmembrane protein 85",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51234);  (R-HSA-9918485)",
        "pathway_count": 2,
        "publication_count": 78,
        "publication_id_list": "11237011;11337487;12682107;15098107;15507651;15838506;17081983;18266465;18586032;18669648;20058876;20166139;22119785;22223895;23084921;23186163;23481700;23658209;24074594;24275569;25418920;25469497;25489052;25576301;25645385;26056282;26154972;26212330;26468529;26811146;26929215;26992070;27600516;27832191;27846572;27920218;28218747;28228285;28832583;28834231;28904123;29242231;29242379;29393594;29493099;29557506;29610346;29632046;29742433;29809151;30315122;30415835;30429286;30484775;30779550;31154438;31720911;31844290;31848261;32111841;32157095;32161166;32265295;32357974;32387766;32439656;32459176;32938616;33298915;33717175;33936100;33968037;34932366;35051231;35318648;36010968;36241641;9931503",
        "class_list": "",
        "function": "ER membrane protein complex subunit 4 (EMC4) and EMC7 support SV40 infection by promoting from the late endosome (LE) to the endoplasmic reticulum (ER) targeting of the virus. They do this by engaging LE-associated Rab7, to stabilize contact between the LE and ER. These EMC subunits also bind to the ER-resident fusion machinery component syntaxin18, which is required for SV40-arrival to the ER. Publication Status: Online-Only, [RefSeq, PubMed]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; TMEM85 is a complex gene that encodes a novel conserved anti-apoptotic protein., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3A9;B4DJQ4;Q96KX9;Q9BUI5;Q9P0T9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0072546 EMC complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006915 apoptotic process;GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "Q5J8M3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P80365-1",
        "uniprot_id": "DHI2_HUMAN",
        "mass": 44127.0,
        "length": 405,
        "protein_name": "11-beta-hydroxysteroid dehydrogenase type 2",
        "gene_name": "HSD11B2",
        "organism": "Human",
        "refseq_name": "11-beta-hydroxysteroid dehydrogenase type 2",
        "refseq_ac": "NP_000187",
        "gene_names_uniprotkb": "HSD11B2; HSD11K; SDR9C3",
        "gene_names_refseq": "AME1; AME; HSD11B2; HSD11K; HSD2; SDR9C3",
        "protein_names_uniprotkb": "11-beta-hydroxysteroid dehydrogenase type 2; 1.1.1.-; 11-DH2; 11-HSD type II; 11-beta-HSD type II; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type II; Corticosteroid 11-beta-dehydrogenase isozyme 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C member 3",
        "protein_names_refseq": "-HSD11 type II; 11-DH2; 11-HSD type II; 11-beta-HSD type II; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-hydroxysteroid dehydrogenase type II; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; corticosteroid 11-beta-dehydrogenase isozyme 2; short chain dehydrogenase/reductase family 9C member 3",
        "tax_id": 9606,
        "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); hypertension (Disease Ontology:DOID:10763); apparent mineralocorticoid excess syndrome (Disease Ontology:DOID:4367); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); inherited metabolic disorder (Disease Ontology:DOID:655); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:3291);  (R-HSA-194002);  (R-HSA-9757110)",
        "pathway_count": 3,
        "publication_count": 104,
        "publication_id_list": "10484077;10489390;10497248;10523339;10665657;10673364;10729196;11237011;11238516;11350956;11504826;11902585;12379510;12466373;12604685;12673034;12788846;12832414;1352877;1356264;1359686;14661924;15175422;15472518;15904907;17200165;17314322;18282684;18513745;1885595;1944309;19447222;1968359;19862647;20190787;20583968;20621639;21490593;22344233;2243100;22796344;23063411;23685396;2570070;25800201;26208431;2639662;27411675;2770297;27927697;28132103;2876781;2889032;2898143;29557506;29769354;29789417;30137266;3038528;30902677;31154438;31701669;31848261;32981041;3299377;33387577;33621325;34211107;34497581;3472246;3487786;35051231;35580925;35735229;3593903;36010968;3709632;37130784;37938771;38814727;6492791;7073761;7195404;7195405;7310640;7400951;7588203;7593417;7608290;7670488;7859916;7865904;8530071;8538347;8611140;8611186;9398712;9543163;9652413;9661590;9683587;9707624;9816258;9851783",
        "class_list": "",
        "function": "Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+) (PubMed:10497248, PubMed:12788846, PubMed:17314322, PubMed:22796344, PubMed:23685396, PubMed:27927697, PubMed:30902677, PubMed:33387577, PubMed:7859916, PubMed:8538347). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids (PubMed:10497248, PubMed:12788846, PubMed:17314322, PubMed:33387577, PubMed:7859916). Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure (By similarity). Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen (PubMed:22796344, PubMed:27927697). Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone (PubMed:23685396, PubMed:27927697). Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro (PubMed:30902677). 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as a ligand for the G protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (PubMed:30902677). May protect ovulating oocytes and fertilizing spermatozoa from the adverse effects of cortisol (By similarity). Catalyzes the conversion of 7-beta-hydroxycholesterol into 7-ketocholesterol (7-oxocholesterol), a precursor of 7-keto,27-hydroxycholesterol, which activates smoothened (SMO) and the smoothened signaling pathway (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; DNA methylation-mediated 11betaHSD2 downregulation drives the increases in angiotensin-converting enzyme and angiotensin II within preeclamptic placentas., [RefSeq, PubMed]; Detection of Urinary Exosomal HSD11B2 mRNA Expression: A Useful Novel Tool for the Diagnostic Approach of Dysfunctional 11beta-HSD2-Related Hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; Down-Regulation of the Mineralocorticoid Receptor (MR) and Up-Regulation of Hydroxysteroid 11-Beta Dehydrogenase Type 2 (HSD11B2) Isoenzyme in Critically Ill Patients., [RefSeq, PubMed]; Long noncoding RNA PVT1 accelerates the growth of placental trophoblasts in preeclampsia through the microRNA-24-3p/HSD11B2 axis., [RefSeq, PubMed]; Rhythm of Fetoplacental 11beta-Hydroxysteroid Dehydrogenase Type 2 - Fetal Protection From Morning Maternal Glucocorticoids., [RefSeq, PubMed]; There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 9,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7LB28;C5HTY7;Q13194;Q6P2G9;Q8N439;Q96QN8;Q99887;Q9UC50;Q9UC51;Q9UCW5;Q9UCW6;Q9UCW7;Q9UCW8",
        "ec_number_list": "1.1.1.146;1.1.1.201;1.1.1.-",
        "go_molecular_function": "GO:0051287 NAD binding;GO:0005496 steroid binding;GO:0070523 11-beta-hydroxysteroid dehydrogenase (NAD+) activity",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0001666 response to hypoxia;GO:0032094 response to food;GO:0051384 response to glucocorticoid;GO:0007565 female pregnancy;GO:0032868 response to insulin",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "P80365-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N5F7-1",
        "uniprot_id": "NKAP_HUMAN",
        "mass": 47138.0,
        "length": 415,
        "protein_name": "NF-kappa-B-activating protein",
        "gene_name": "NKAP",
        "organism": "Human",
        "refseq_name": "NF-kappa-B-activating protein",
        "refseq_ac": "NP_078804",
        "gene_names_uniprotkb": "NKAP",
        "gene_names_refseq": "MRXSHD; NKAP",
        "protein_names_uniprotkb": "NF-kappa-B-activating protein",
        "protein_names_refseq": "NF-kappa-B-activating protein; NF-kappaB activating protein",
        "tax_id": 9606,
        "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); carcinoma (Disease Ontology:DOID:305); intellectual developmental disorder, X-linked, syndromic, Hackmann-Di Donato type (MONDO:MONDO:0026733)",
        "pathway": " (hsa:79576);  (R-HSA-72163)",
        "pathway_count": 2,
        "publication_count": 134,
        "publication_id_list": "10882114;11014198;11101529;11233976;11237011;11991638;12176931;12411573;12414731;12477934;14550261;14625303;14713954;15302935;15345747;16314458;16809785;17081983;17095540;17332742;17525332;17606899;18077418;18322460;18452278;18491316;18593880;18669648;18691976;18707149;18767875;18804983;19103666;19165350;19409814;19413330;19415658;19536130;19608861;19651622;19664994;19664995;19690332;20058876;20068231;20230923;20423332;20980672;21406692;21536652;21624937;2176635;22110043;22365833;22959432;22961380;23186163;23222130;23236153;23345524;24196718;24304693;24448447;24737827;24914973;25505266;25555158;2558966;25892735;26154972;26358559;26385511;26420826;26969736;26992070;27377154;27459055;27683217;27846572;27862975;27920218;28062851;28076346;28411811;28502770;28514659;28781166;28832583;28834231;28904123;29301961;29360106;29361316;29632711;2963332;30315277;30705154;30728453;30765414;30975767;31154438;31409651;31587868;31844290;32157095;32179686;32329775;32494006;32502341;33243851;33298915;33446560;34171305;34301950;34822310;35051231;35064112;35385551;37217939;3757028;38253038;38647244;38665916;40596516;8566756;8608946;9016565;9242493;9512519;9524131;9539711;9671485;9701291;9731529",
        "class_list": "",
        "function": "Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter., [UniProtKB, PubMed, PubMed, PubMed]; From phenotype to mechanism: Prenatal spectrum of NKAP mutation-related disorder and its pathogenesis inducing congenital heart disease., [RefSeq, PubMed]; NKAP functions as a transcriptional repressor, acting on Notch target genes, and is required for alphabeta T cell development., [RefSeq, PubMed]; NKAP is a novel nuclear regulator of TNF- and IL-1-induced NF-kappaB activation, [RefSeq, PubMed]; NKAP is required for T cell maturation and the acquisition of functional competency, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m(6)A-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
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        "total_reported_c_glycosites": 0,
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        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IPW6;Q96BQ2;Q9H638",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0031490 chromatin DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0045892 negative regulation of DNA-templated transcription;GO:0046638 positive regulation of alpha-beta T cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "Q8N5F7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9GZR7-1",
        "uniprot_id": "DDX24_HUMAN",
        "mass": 96332.0,
        "length": 859,
        "protein_name": "ATP-dependent RNA helicase DDX24",
        "gene_name": "DDX24",
        "organism": "Human",
        "refseq_name": "ATP-dependent RNA helicase DDX24",
        "refseq_ac": "NP_065147",
        "gene_names_uniprotkb": "DDX24",
        "gene_names_refseq": "DDX24",
        "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX24; 3.6.4.13; DEAD box protein 24",
        "protein_names_refseq": "ATP-dependent RNA helicase DDX24; DEAD (Asp-Glu-Ala-Asp) box helicase 24; DEAD (Asp-Glu-Ala-Asp) box polypeptide 24; DEAD box protein 24; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 24; S. cerevisiae CHL1-like helicase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57062)",
        "pathway_count": 1,
        "publication_count": 129,
        "publication_id_list": "10936056;11230166;11237011;15302935;16964243;17081983;17322306;17525332;18289627;18318008;18452278;18669648;18691976;18767875;19007248;19413330;19415658;19608861;19651622;19690332;19691289;20068231;21406692;22645359;22869377;23186163;23481700;24029068;24204270;24275569;24366607;24714562;24715725;24980433;25418920;25576301;25645385;25810538;25867071;25880248;25892735;26024233;26154972;26375851;26728094;26754738;26768311;26992070;27600516;27846572;27920218;28063628;28228285;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30410026;30484775;30524438;30779550;31154438;31217245;31222486;31373491;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33091337;33123756;33141586;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34932366;35051231;35251023;35318648;35561310;35580925;35864588;36010968;36241641;36284347;36298642;36581221;37705750;37938771;38043669;38612434",
        "class_list": "",
        "function": "(Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles (PubMed:24204270)., [UniProtKB, PubMed, PubMed]; ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity. Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation. Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation. Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; DDX24 Mutation Alters NPM1 Phase Behavior and Disrupts Nucleolar Homeostasis in Vascular Malformations. Publication Status: Online-Only, [RefSeq, PubMed]; DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer., [RefSeq, PubMed]; DDX24 promotes tumor progression by mediating hexokinase-1 induced glycolysis in gastric cancer., [RefSeq, PubMed]; DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App[N-LF] Mice and Influences Presymptomatic Pathology. Publication Status: Online-Only, [RefSeq, PubMed]; DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]., [RefSeq]; DExD/H Box Helicases DDX24 and DDX49 Inhibit Reactivation of Kaposi's Sarcoma Associated Herpesvirus by Interacting with Viral mRNAs. Publication Status: Online-Only, [RefSeq, PubMed]; RNA helicase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E7EMJ4;Q4V9L5",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005634 nucleus",
        "go_biological_process": "GO:0016070 RNA metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.3,
        "record_id": "Q9GZR7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P49593-1",
        "uniprot_id": "PPM1F_HUMAN",
        "mass": 49831.0,
        "length": 454,
        "protein_name": "Protein phosphatase 1F",
        "gene_name": "PPM1F",
        "organism": "Human",
        "refseq_name": "protein phosphatase 1F isoform 1",
        "refseq_ac": "NP_055449",
        "gene_names_uniprotkb": "PPM1F; KIAA0015; POPX2",
        "gene_names_refseq": "CAMKP; CaMKPase; FEM-2; POPX2; PPM1F; hFEM-2",
        "protein_names_uniprotkb": "Protein phosphatase 1F; 3.1.3.16; Ca(2+)/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; CaMKPase; Partner of PIX 2; Protein fem-2 homolog; hFem-2",
        "protein_names_refseq": "Ca(2+)/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; PP2C phosphatase; partner of PIX 2; protein fem-2 homolog; protein phosphatase 1F (PP2C domain containing); protein phosphatase 1F isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9647);  (R-HSA-9617324)",
        "pathway_count": 2,
        "publication_count": 26,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;11237011;11559703;11864573;12807427;15140879;16959974;18477386;20068231;21656682;23186163;23584533;29557506;30250217;31222486;31844290;32157095;32350084;32357974;32387766;33042261;33119040;35051231;35580925;38301894",
        "class_list": "",
        "function": "Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus. Publication Status: Online-Only, [RefSeq, PubMed]; Data identify a biochemical pathway through which POPX2 exerts its apparent cellular function: the regulation of activity of glycogen synthase kinase-3, which in turn modulates extracellular signal-regulated kinase and cell motility., [RefSeq, PubMed]; Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis., [UniProtKB, UniProtKB, UniProtKB]; PPM1F controls integrin activity via a conserved phospho-switch., [RefSeq, PubMed]; PPM1F plays a key role in the regulation of CaMKII intracellularly, [RefSeq, PubMed]; The BHLHE40-PPM1F-AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer., [RefSeq, PubMed]; The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. (POPX1; POPX2), [RefSeq, PubMed]; The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6G3;B7Z2C3;Q96PM2",
        "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.-;3.1.3.67;3.1.3.53;2.7.11.17;3.1.3.52;3.1.3.27;3.1.3.86;3.1.3.36;3.1.3.74",
        "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "P49593-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q04637-1",
        "uniprot_id": "IF4G1_HUMAN",
        "mass": 175491.0,
        "length": 1599,
        "protein_name": "Eukaryotic translation initiation factor 4 gamma 1",
        "gene_name": "EIF4G1",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 4 gamma 1 isoform 4",
        "refseq_ac": "NP_004944",
        "gene_names_uniprotkb": "EIF4G1; EIF4F; EIF4GI; EIF4G",
        "gene_names_refseq": "EIF-4G1; EIF4F; EIF4G1; EIF4GI; EIF4G; P220; PARK18",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4 gamma 1; eIF-4-gamma 1; eIF-4G 1; eIF-4G1; p220",
        "protein_names_refseq": "EIF4-gamma; eIF-4-gamma 1; eucaryotic translation initiation factor 4G; eukaryotic translation initiation factor 4 gamma 1 isoform 4",
        "tax_id": 9606,
        "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); Parkinson's disease (Disease Ontology:DOID:14330); Parkinson disease 18, autosomal dominant, susceptibility to (MONDO:MONDO:0013653)",
        "pathway": " (hsa:1981);  (R-HSA-1169408);  (R-HSA-156827);  (R-HSA-166208);  (R-HSA-429947);  (R-HSA-450408);  (R-HSA-72649);  (R-HSA-72662);  (R-HSA-72702);  (R-HSA-72706);  (R-HSA-9010553);  (R-HSA-975956);  (R-HSA-975957);  (R-HSA-9820841);  (R-HSA-9820865);  (R-HSA-9918487)",
        "pathway_count": 16,
        "publication_count": 374,
        "publication_id_list": "10.1101/2023.09.13.557529;10205060;10364207;10559216;10637334;10654941;10659855;10872469;10882133;1095581;10970864;10996799;11018020;11034318;11095724;11112487;11154262;11157743;11237011;11283721;11331269;11532962;11544179;11546874;11551508;11788588;11821405;11842200;11889047;12052860;12086624;12136087;12150926;12417715;12525615;12554878;12582176;12588972;12718880;12742462;12819195;12832468;1355481;1429670;14527413;14567916;14583602;14636577;14742663;14749774;14973490;15034551;15131269;15257295;15314020;15314025;15475613;15485925;15546618;15592455;15702989;15721257;15755734;15809305;16009940;16112642;16122702;16139798;16141059;16186820;16209946;16284618;16352599;16407192;16408927;16428300;16452507;16513844;16556936;16601204;16622410;16698552;16699525;16715065;16775314;16815975;16872604;16914094;16959974;16964243;16982693;17052452;17053788;17081983;1715244;17245413;17284590;17287340;17289916;17322306;17352659;17363904;17376915;17547437;17595167;17697703;17803942;17893241;17924679;17984221;18025107;18066079;18088087;18212344;18230761;18256688;18287095;18305167;18423202;18447580;18447585;18452278;18524595;1856230;18573886;18583345;18625844;18657639;18669648;18691976;18767875;18799579;18974281;19022411;19060897;19073728;19125153;19150429;19239894;19270716;19359157;19413330;19415658;19417104;19478851;19503078;19556969;19558367;19608861;19651622;19664994;19664995;19691289;19706539;19859661;19909264;20023408;20058876;20068230;20068231;20133869;20166139;20219937;20308324;20385878;20479275;20691628;20817927;20930030;20934997;21029861;21145460;21158410;21209280;21406692;21419344;21576361;21602892;21654843;21907011;22424782;22544926;22872150;22898188;23085078;23186163;23217742;23234702;23301498;23481700;23746841;24129315;24275569;24366607;24397554;24423872;24714562;24715725;24979134;25242263;25418920;25480299;25576301;25645385;25802875;25810538;25880248;26154972;26375851;26728094;26735137;26740508;26811146;26853435;26929215;26992070;27397612;27600516;27655845;27846572;27862975;27920218;28063628;28218747;28228285;28510447;28514659;28832583;28834231;28860189;28904123;29062139;29117567;291969;29237092;29242379;29314611;29331515;29351928;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;29987188;30059200;30127386;30315122;30379171;30410026;30484775;30524438;30620550;30779550;30833945;30940748;31020640;31092671;31154438;31217245;31222486;31300553;31373491;31492838;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32502391;32574038;32870666;32890404;32897882;32938616;32938750;32983136;33043033;33091337;33141586;33214551;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34405274;34509645;34561969;34647228;34696522;34725712;34846842;34932366;35008409;35051231;35083852;35132862;35138101;35163752;35251023;35254053;35289036;35318648;35513511;35561310;35580925;35585045;35705054;36010968;36215666;36241641;36284347;37217939;37340703;37938771;38177122;38266053;38665916;38838015;39390016;39531497;39534244;40307207;40596516;40914422;429297;592398;592399;641056;6853548;7000367;7559393;7651417;7935836;8396129;8449919;8521827;8943342;8961935;9045610;9099687;9372926;9418880;9525617;9721431;9732867;9755181;9755863;9857202;9878069",
        "class_list": "",
        "function": "Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139)., [UniProtKB, PubMed, PubMed]; Computational inference of eIF4F complex function and structure in human cancers., [RefSeq, PubMed]; Data suggest that expression of the eIF4GI isoforms is partly controlled by a complex translation strategy involving both cap-dependent and cap-independent mechanisms, [RefSeq, PubMed]; Intact eIF4GI protein is not required for the de novo synthesis of eIF4GI, suggesting its expression can continue under stress or infection conditions where eIF4GI is cleaved, [RefSeq, PubMed]; Mass spectrometric analysis of N terminus reveals novel isoforms, [RefSeq, PubMed]; The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]., [RefSeq]; USP10 promotes cell proliferation, migration, and invasion in NSCLC through deubiquitination and stabilization of EIF4G1. Publication Status: Online-Only, [RefSeq, PubMed]; We quantify the efficiency of eIF4GI promoter usage in mammalian cells and demonstrate that even though the longest isoform eIF4GIf was relatively poorly expressed when reintroduced, it was more efficient at promoting the translation of cellular mRNAs., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 20,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 20,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 20,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 34,
        "reported_mutagensis": 26,
        "reported_glycation": 0,
        "reported_snv": 54,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 25,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DNT2;D3DNT4;D3DNT5;E9PFM1;G5E9S1;O43177;O95066;Q5HYG0;Q6ZN21;Q8N102",
        "ec_number_list": "",
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0008190 eukaryotic initiation factor 4E binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0016281 eukaryotic translation initiation factor 4F complex",
        "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0051247 positive regulation of protein metabolic process;GO:0097009 energy homeostasis;GO:0006413 translational initiation;GO:0010507 negative regulation of autophagy",
        "synthesized_glycan_count": 0,
        "hit_score": 39.8,
        "record_id": "Q04637-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H9R9-1",
        "uniprot_id": "DBND1_HUMAN",
        "mass": 17042.0,
        "length": 158,
        "protein_name": "Dysbindin domain-containing protein 1",
        "gene_name": "DBNDD1",
        "organism": "Human",
        "refseq_name": "dysbindin domain-containing protein 1 isoform 1",
        "refseq_ac": "NP_001036075",
        "gene_names_uniprotkb": "DBNDD1",
        "gene_names_refseq": "DBNDD1",
        "protein_names_uniprotkb": "Dysbindin domain-containing protein 1",
        "protein_names_refseq": "dysbindin (dystrobrevin binding protein 1) domain containing 1; dysbindin domain-containing protein 1 isoform 1; dysbindin domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79007)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;19077176;19349376;23186163;24275569;28904123;30779550;32357974;33981976;35474152;36241641",
        "class_list": "",
        "function": "Backbone and side chain resonance assignment of the intrinsically disordered human DBNDD1 protein., [RefSeq, PubMed]; Our results therefore support involvement of the dysbindin gene in cognitive function, [RefSeq, PubMed]; TRIM32 is a widely expressed ubiquitin ligase and binds and ubiquitinates dysbindin., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DQS3;Q69YT2;Q9BW25",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0009966 regulation of signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9H9R9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N3D4-1",
        "uniprot_id": "EH1L1_HUMAN",
        "mass": 161854.0,
        "length": 1523,
        "protein_name": "EH domain-binding protein 1-like protein 1",
        "gene_name": "EHBP1L1",
        "organism": "Human",
        "refseq_name": "EH domain-binding protein 1-like protein 1 isoform 1",
        "refseq_ac": "NP_001092879",
        "gene_names_uniprotkb": "EHBP1L1",
        "gene_names_refseq": "EHBP1L1",
        "protein_names_uniprotkb": "EH domain-binding protein 1-like protein 1",
        "protein_names_refseq": "EH domain-binding protein 1-like protein 1 isoform 1; EH domain-binding protein 1-like protein 1; tangerin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:254102)",
        "pathway_count": 1,
        "publication_count": 57,
        "publication_id_list": "11237011;17081983;18220336;18452278;18669648;18767875;19651622;20068231;23186163;23481700;24275569;24715725;25418920;25576301;26154972;26811146;26833786;26929215;26992070;27552051;27600516;27846572;27920218;28218747;28832583;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29786170;30192525;30379171;30410026;30429286;31844290;32157095;32265295;32350084;32357974;32387766;32897882;32938616;32983136;33298915;33912179;33968037;34211107;34561969;35051231;35580925;36241641;36284347;36775874;37217939",
        "class_list": "",
        "function": "Data demonstrate that EHBP1L1 links Rab8 and the Bin1-dynamin complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport., [RefSeq, PubMed]; EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1., [RefSeq, PubMed]; May act as Rab effector protein and play a role in vesicle trafficking., [UniProtKB, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8TB89;Q9H7M7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0032456 endocytic recycling",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q8N3D4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P57678-1",
        "uniprot_id": "GEMI4_HUMAN",
        "mass": 120037.0,
        "length": 1058,
        "protein_name": "Gem-associated protein 4",
        "gene_name": "GEMIN4",
        "organism": "Human",
        "refseq_name": "gem-associated protein 4 isoform 1",
        "refseq_ac": "NP_056536",
        "gene_names_uniprotkb": "GEMIN4",
        "gene_names_refseq": "GEMIN4; HC56; HCAP1; HHRF-1; NEDMCR; p97",
        "protein_names_uniprotkb": "Gem-associated protein 4; Component of gems 4; Gemin-4; p97",
        "protein_names_refseq": "HCC-associated protein 1; component of gems 4; gem-associated protein 4 isoform 1; gemin-4",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities (Disease Ontology:DOID:0081263)",
        "pathway": " (hsa:50628);  (R-HSA-191859);  (R-HSA-9754678)",
        "pathway_count": 3,
        "publication_count": 102,
        "publication_id_list": "10531003;10556282;10601333;10725331;10851237;11230166;11237011;11333016;11714716;11748230;12065586;12095920;12441251;12668731;12776181;16314521;17178713;18669648;18984161;18991276;19838190;20068231;22424782;23186163;23301498;24715725;25505266;25558065;26154972;26992070;27846572;27862975;28514659;28832583;28904123;29242379;29275860;29493099;29557506;30237576;30315122;30484775;30779550;30833945;31154438;31222486;31844290;31848261;31937595;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32680882;32897882;32908316;32938616;32983136;32995776;32995777;33080218;33091337;33141586;33188728;33268501;33298915;33392160;33479166;33592498;33717175;33912179;33936100;33963192;33968037;33981976;34087483;34171305;34185709;34211107;34315815;34373319;34405274;34509645;34561969;34624207;34725712;34932366;35051231;35384865;35561310;35580925;35861185;36010968;36215666;36241641;36610391;38401326;8196654;9845364",
        "class_list": "",
        "function": "Association of GEMIN4 gene polymorphisms with the risk of colorectal cancer in the Polish population., [RefSeq, PubMed]; Further delineation of GEMIN4 related neurodevelopmental disorder with microcephaly, cataract, and renal abnormalities syndrome., [RefSeq, PubMed]; GEMIN4 Variants: Risk Profiling, Bioinformatics, and Dynamic Simulations Uncover Susceptibility to Bladder Carcinoma., [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP., [UniProtKB, PubMed]; The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NZS7;Q9UG32;Q9Y4Q2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0006364 rRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "P57678-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15523-1",
        "uniprot_id": "DDX3Y_HUMAN",
        "mass": 73154.0,
        "length": 660,
        "protein_name": "ATP-dependent RNA helicase DDX3Y",
        "gene_name": "DDX3Y",
        "organism": "Human",
        "refseq_name": "ATP-dependent RNA helicase DDX3Y isoform 1",
        "refseq_ac": "NP_001116137",
        "gene_names_uniprotkb": "DDX3Y; DBY",
        "gene_names_refseq": "DBY; DDX3Y",
        "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX3Y; 3.6.4.13; DEAD box protein 3, Y-chromosomal",
        "protein_names_refseq": "ATP-dependent RNA helicase DDX3Y isoform 1; ATP-dependent RNA helicase DDX3Y; DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; DEAD box protein 3, Y-chromosomal; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, Y chromosome",
        "tax_id": 9606,
        "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457); childhood medulloblastoma (Disease Ontology:DOID:3869)",
        "pathway": " (hsa:8653)",
        "pathway_count": 1,
        "publication_count": 38,
        "publication_id_list": "11237011;11929796;15144186;15294876;15383328;15570572;17085304;18299450;18691976;19415658;20068231;20112406;20160060;22889757;24582729;25576301;25880248;25892735;26154972;26992070;28832583;29242379;29393594;29557506;30315122;30397120;31848261;33123756;33592498;33968037;33981976;35051231;36284347;36997603;37363859;38217953;38253038;9381176",
        "class_list": "",
        "function": "Antibody-mediated pathogenesis of chronic GVHD through DBY/HLA class II complexes and induction of a GVL effect., [RefSeq, PubMed]; Antioncogenic roles of USP9Y and DDX3Y in lung cancer: USP9Y stabilizes DDX3Y by preventing its degradation through deubiquitination., [RefSeq, PubMed]; DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human non-obstructive azoospermia. Publication Status: Online-Only, [RefSeq, PubMed]; Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity)., [UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DK29;B4DXX7;Q8IYV7",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0043186 P granule",
        "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0007276 gamete generation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "O15523-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13435-1",
        "uniprot_id": "SF3B2_HUMAN",
        "mass": 100228.0,
        "length": 895,
        "protein_name": "Splicing factor 3B subunit 2",
        "gene_name": "SF3B2",
        "organism": "Human",
        "refseq_name": "splicing factor 3B subunit 2",
        "refseq_ac": "NP_006833",
        "gene_names_uniprotkb": "SF3B2; SAP145",
        "gene_names_refseq": "CFM; Cus1; HFM; SAP145; SF3B145; SF3B2; SF3b150; SF3b1",
        "protein_names_uniprotkb": "Splicing factor 3B subunit 2; Pre-mRNA-splicing factor SF3b 145 kDa subunit; SAP 145; SF3b145; Spliceosome-associated protein 145",
        "protein_names_refseq": "SAP 145; pre-mRNA splicing factor SF3b 145 kDa subunit; spliceosome associated protein 145; splicing factor 3B subunit 2; splicing factor 3b, subunit 2, 145kDa; splicing factor 3b, subunit 2, 145kD",
        "tax_id": 9606,
        "disease": "Goldenhar syndrome (Disease Ontology:DOID:2907)",
        "pathway": " (hsa:10992);  (R-HSA-72163);  (R-HSA-72165);  (R-HSA-9770562);  (R-HSA-9918481);  (R-HSA-9943411)",
        "pathway_count": 6,
        "publication_count": 276,
        "publication_id_list": "10199952;10207048;10669729;10882114;11014198;11060040;11101529;11233976;11237011;11333026;11607023;11747608;11991638;12176931;12234937;12411573;12414731;12477934;12682017;12738865;14519844;14625303;14713954;14749727;14762106;15037765;15084397;15104674;15146077;15302935;15565158;15647753;16263726;16314458;16372014;16809785;16923959;17081983;17095540;17128255;17287340;17332742;17433364;17525332;17606899;17717186;17940139;18042460;18288197;18318008;18322460;18452278;18593880;18669648;18691976;19052544;19103666;19165350;19217410;19413330;19415658;19536130;19608861;19651622;19664994;19664995;19690332;20068231;20166139;20211137;20423332;20695905;20980672;21295486;21406692;21536652;2176635;21911577;22046413;22110043;22121020;22365833;22569126;22706990;22813749;22922743;22959432;22961380;23186163;23222130;23236153;23345524;23481700;23874216;24076191;24129315;24149845;24196718;24275569;24304693;24397554;24448447;24714562;24715725;24737827;24914973;25218447;2524422;25301780;25301781;25418920;25555158;25576301;2558966;25645385;25737013;25755297;25772364;25810538;25880248;25892735;25979344;26030138;26092250;26154972;26375851;26385511;26420826;26728094;26768311;26811146;26969736;26992070;27108190;27377154;27397612;27459055;27503676;27510544;27600516;27661449;27683217;27720643;27846572;27862975;27905398;27920218;28062851;28063628;28076346;28096519;28218747;28228285;28411811;28502770;28510447;28514659;28541300;28781166;28832583;28834231;28860189;28904123;28911096;29186539;29242379;29274231;29301961;29360106;29361316;29393594;29437277;29493099;29508533;29557506;29632046;29632711;2963332;29786170;29789417;29902443;30139799;30192525;30257008;30315122;30315277;30484775;30599162;30705154;30728453;30765414;30779550;30833945;30975767;31154438;31217245;31222486;31409651;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32179686;32265295;32329775;32350084;32357974;32387766;32488085;32494006;32502341;32522876;32816001;32897882;32938616;32983136;33141586;33177556;33214551;33243851;33298915;33392160;33446560;33509932;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34301950;34344887;34509645;34561969;34822310;34932366;35051231;35138101;35154160;35177536;35215846;35251023;35318648;35385551;35580925;36010968;36241641;36284347;36581221;36797247;37217939;3757028;37938771;38665916;40914422;8566756;8608946;8835860;9016565;9242493;9512519;9524131;9539711;9659921;9671485;9701291;9731529",
        "class_list": "",
        "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 38,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K485;B4DT19;Q7L4T5;Q7Z627;Q969K1;Q96CM6;Q9BWD2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)",
        "synthesized_glycan_count": 0,
        "hit_score": 27.9,
        "record_id": "Q13435-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43491-1",
        "uniprot_id": "E41L2_HUMAN",
        "mass": 112588.0,
        "length": 1005,
        "protein_name": "Band 4.1-like protein 2",
        "gene_name": "EPB41L2",
        "organism": "Human",
        "refseq_name": "band 4.1-like protein 2 isoform b",
        "refseq_ac": "NP_001129026",
        "gene_names_uniprotkb": "EPB41L2",
        "gene_names_refseq": "4.1-G; 4.1G; EPB41L2",
        "protein_names_uniprotkb": "Band 4.1-like protein 2; 4.1G; Erythrocyte membrane protein band 4.1-like 2; Generally expressed protein 4.1",
        "protein_names_refseq": "band 4.1-like protein 2 isoform b; band 4.1-like protein 2; erythrocyte membrane protein band 4.1 like-protein 2; generally expressed protein 4.1",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)",
        "pathway": " (hsa:2037);  (R-HSA-6794361)",
        "pathway_count": 2,
        "publication_count": 141,
        "publication_id_list": "11237011;11604393;15302935;15540461;16242404;16254212;16624946;16846852;16964243;17081983;17287340;17525332;17897391;18023480;18077418;18083107;18212344;18452278;18578522;18669648;18707149;18812509;18829961;18991276;19413330;19651622;19664994;19664995;19690332;19691289;20058876;20064387;20064388;20068231;20166139;20519524;21282647;21406692;22223895;22361696;23186163;23301498;23481700;23870127;24275569;24714562;24715725;25378172;25502872;25576301;25645385;25755297;25802875;25880248;26154972;26728094;26811146;26992070;27862975;28510447;28657654;28904123;29351928;29393594;29437277;29557506;30315122;30379171;30410026;30429286;30620550;30784271;30833945;31092671;31154438;31217245;31222486;31383768;31530632;31717259;31844290;31848261;31998317;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32938750;32983136;33123756;33214551;33298915;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34022068;34087483;34171305;34357683;34405274;34509645;34725712;34846842;34932366;35051231;35132862;35138101;35251023;35254053;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37340703;37938771;38665916;39302247;39531497;7695896;7736595;8576240;9069287;9598318;9808458;9927700",
        "class_list": "",
        "function": "Data found that direct binding of 4.1G to the N-terminus of AC6 (AC6-N) contributes to the plasma membrane association of AC6-N and the resulting suppression of AC6 cyclase activity., [RefSeq, PubMed]; Exosomal circEPB41L2 serves as a sponge for miR-21-5p and miR-942-5p to suppress colorectal cancer progression by regulating the PTEN/AKT signalling pathway., [RefSeq, PubMed]; Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 15,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 15,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 15,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 38,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DHI8;E9PPD9;Q5T4F0;Q68DV2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0005198 structural molecule activity;GO:0030507 spectrin binding;GO:0042731 PH domain binding;GO:0008092 cytoskeletal protein binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005925 focal adhesion",
        "go_biological_process": "GO:0051301 cell division;GO:0031032 actomyosin structure organization;GO:0030866 cortical actin cytoskeleton organization;GO:1904778 positive regulation of protein localization to cell cortex",
        "synthesized_glycan_count": 0,
        "hit_score": 15.8,
        "record_id": "O43491-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P80370-1",
        "uniprot_id": "DLK1_HUMAN",
        "mass": 41300.0,
        "length": 383,
        "protein_name": "Protein delta homolog 1",
        "gene_name": "DLK1",
        "organism": "Human",
        "refseq_name": "protein delta homolog 1 isoform 2 preproprotein",
        "refseq_ac": "NP_001304101",
        "gene_names_uniprotkb": "DLK1; DLK",
        "gene_names_refseq": "DLK-1; DLK1; DLK; Delta1; FA1; PREF1; Pref-1; ZOG; pG2",
        "protein_names_uniprotkb": "Protein delta homolog 1; DLK-1; pG2",
        "protein_names_refseq": "delta-like 1 homolog; fetal antigen 1; preadipocyte factor 1; protein delta homolog 1 isoform 2 preproprotein; protein delta homolog 1; secredeltin",
        "tax_id": 9606,
        "disease": "biliary atresia (Disease Ontology:DOID:13608); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070)",
        "pathway": " (hsa:8788);  (R-HSA-2122948)",
        "pathway_count": 2,
        "publication_count": 68,
        "publication_id_list": "10.1038/emboj.2013.79;10206645;10879540;10882063;11006133;11076856;11226752;11237011;11740940;12209127;12354787;12530964;14567914;15340161;15574878;15652348;15760269;15824097;15829515;15965470;16093323;16284625;17003037;17028573;17401372;18043734;18077452;18237417;18296446;18398438;18628966;18700817;18824583;18824585;19000840;19151708;19524514;19567869;19726682;22162134;22171320;2308864;23584533;27543614;30078552;30459171;31611695;32350084;34087483;35051231;35251023;35494241;37938771;38609422;40637009;7711066;7925474;8095043;8313469;8501199;9244301;9315665;9462510;9590294;9604939;9620803;9651681;9819428",
        "class_list": "",
        "function": "Associated with extreme early-onset obesity. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; DLK1 gene is imprinted, with preferential expression from the paternal allele., [RefSeq, PubMed]; May have a role in neuroendocrine differentiation., [UniProtKB]; MiRNAs from the Dlk1-Dio3 locus and miR-224/452 cluster contribute to glioblastoma tumor heterogeneity. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 8,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 14,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 14,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 47,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 4,
        "glyco_site_count": 16,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P15803;Q96DW5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "GO:0030154 cell differentiation;GO:0045780 positive regulation of bone resorption;GO:0045668 negative regulation of osteoblast differentiation;GO:0045746 negative regulation of Notch signaling pathway;GO:0030279 negative regulation of ossification",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "P80370-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7L7V1-1",
        "uniprot_id": "DHX32_HUMAN",
        "mass": 84419.0,
        "length": 743,
        "protein_name": "Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32",
        "gene_name": "DHX32",
        "organism": "Human",
        "refseq_name": "putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32",
        "refseq_ac": "NP_060650",
        "gene_names_uniprotkb": "DHX32; DDX32",
        "gene_names_refseq": "DDX32; DHLP1; DHX32",
        "protein_names_uniprotkb": "Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32; 3.6.4.13; DEAD/H box 32; DEAD/H helicase-like protein 1; DEAH box protein 32; DHLP1; HuDDX32",
        "protein_names_refseq": "DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32; DEAD/H box 32; DEAD/H helicase-like protein-1; DEAH (Asp-Glu-Ala-His) box polypeptide 32; DEAH box protein 32; huDDX32; putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55760)",
        "pathway_count": 1,
        "publication_count": 55,
        "publication_id_list": "11237011;12163057;12527204;16181624;16414036;16959245;16959974;20068231;20112406;25576301;25892735;26375851;26992070;27600516;27846572;28063628;28832583;28834231;28904123;29242379;29331515;29393594;29557506;29786170;30484775;30779550;31154438;31844290;31848261;31965981;32157095;32350084;32387766;32488085;32897882;32938616;33123756;33537174;33592498;33691108;33717175;33729094;33968037;34185709;34509645;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37938771",
        "class_list": "",
        "function": "Cloned DHX32 proximal promoter and identified a 218bp fragment containing two potential binding sites for the transcription factor nuclear factor of activated T cells (NF-AT), [RefSeq, PubMed]; DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined. [provided by RefSeq, Jul 2008]., [RefSeq]; DEAH-box polypeptide 32 promotes hepatocellular carcinoma progression via activating the beta-catenin pathway., [RefSeq, PubMed]; Hypoxia-induced changes in intragenic DNA methylation correlate with alternative splicing in breast cancer., [RefSeq, PubMed]; Structural characterization and expression of the DDX32 gene. Expression studies show that DDX32 is widespread but specifically down-regulated in acute lymphoblastic leukemias and might play a role in normal and/or abnormal lymphopoiesis., [RefSeq, PubMed]; These results suggest that DHX32 is a putative RNA helicase that might be involved in regulating nuclear and mitochondrial gene expression., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MSV2;D3DRF9;Q49AG5;Q5T3L0;Q5T3L5;Q96NY1;Q9BUN0;Q9H769;Q9NSL5;Q9NV74;Q9NVJ7",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity;GO:0003724 RNA helicase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005681 spliceosomal complex;GO:0005634 nucleus",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q7L7V1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5TKA1-1",
        "uniprot_id": "LIN9_HUMAN",
        "mass": 61946.0,
        "length": 542,
        "protein_name": "Protein lin-9 homolog",
        "gene_name": "LIN9",
        "organism": "Human",
        "refseq_name": "protein lin-9 homolog isoform 2",
        "refseq_ac": "NP_001257338",
        "gene_names_uniprotkb": "LIN9; BARA; TGS",
        "gene_names_refseq": "BARA; BARPsv; LIN9; Lin-9; TGS2; TGS",
        "protein_names_uniprotkb": "Protein lin-9 homolog; Beta subunit-associated regulator of apoptosis; HuLin-9; TUDOR gene similar protein; Type I interferon receptor beta chain-associated protein; hLin-9; pRB-associated protein",
        "protein_names_refseq": "TUDOR gene similar protein; beta subunit-associated regulator of apoptosis; pRB-associated protein; protein lin-9 homolog isoform 2; protein lin-9 homolog; rb related pathway actor; type I interferon receptor beta chain-associated protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:286826);  (R-HSA-1362277);  (R-HSA-1362300);  (R-HSA-1538133);  (R-HSA-156711);  (R-HSA-69202);  (R-HSA-69205);  (R-HSA-69656)",
        "pathway_count": 8,
        "publication_count": 107,
        "publication_id_list": "10228158;10323868;10375532;10454565;10454584;10597240;10692433;11231585;11237011;11585773;11897663;11907280;11959842;11988738;12730199;12738781;12782299;1312467;1396589;14990995;15014447;15037762;15070733;15510213;15538385;15654331;16582612;16730350;17098733;17159899;17531812;17671431;18220336;18669648;18691976;19160488;19690332;20068231;21498570;22391450;23109430;23186163;23240008;24475316;25418920;25505266;25576301;25892735;26811146;26992070;27600516;27846572;27920218;28061449;28218747;28228285;28514659;28807940;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29769354;29786170;30379171;30484775;31844290;32054769;32157095;32387766;32502341;32897882;32938616;32983136;33392160;33717175;33912179;35051231;36010968;36215666;36241641;7623816;7629134;7743995;7799941;7929342;8050359;8114698;8288595;8618861;8700224;8703070;8943353;9020173;9199292;9482921;9520412;9632134;9662327;9724731;9778043;9891042",
        "class_list": "",
        "function": "Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition., [UniProtKB, PubMed, PubMed]; High LIN9 expression is associated with Triple-negative breast cancers., [RefSeq, PubMed]; Human LIN-9, together with B-MYB, has a critical role in the activation of genes that are essential for progression into mitosis, [RefSeq, PubMed]; Human Lin-9 has tumor-suppressing activities and the ability of hLin-9 to inhibit transformation is mediated through its association with pRB., [RefSeq, PubMed]; LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression. Publication Status: Online-Only, [RefSeq, PubMed]; LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance., [RefSeq, PubMed]; Mip/LIN-9 is required for the expression of B-Myb, and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A, cyclin B, and CDK1, [RefSeq, PubMed]; Mutation of BARA/LIN-9 restores the expression of E2F target genes., [RefSeq, PubMed]; The MuvB multiprotein complex, together with B-MYB and FOXM1 (MMB-FOXM1) regulate the expression of mitotic kinesins in breast cancer cells., [RefSeq, PubMed]; This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5U5L8;Q5U7E1;Q6PI55;Q6ZTV4;Q7Z3J1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex",
        "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 11.0,
        "record_id": "Q5TKA1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q0VDD8-1",
        "uniprot_id": "DYH14_HUMAN",
        "mass": 399895.0,
        "length": 3507,
        "protein_name": "Dynein axonemal heavy chain 14",
        "gene_name": "DNAH14",
        "organism": "Human",
        "refseq_name": "dynein axonemal heavy chain 14 isoform 2",
        "refseq_ac": "NP_001138626",
        "gene_names_uniprotkb": "DNAH14; C1orf67",
        "gene_names_refseq": "C1orf67; DNAH14; Dnahc14; HL-18; HL18",
        "protein_names_uniprotkb": "Dynein axonemal heavy chain 14; Axonemal beta dynein heavy chain 14; Ciliary dynein heavy chain 14",
        "protein_names_refseq": "axonemal beta dynein heavy chain 14; ciliary dynein heavy chain 14; dynein axonemal heavy chain 14 isoform 2; dynein heavy chain 14, axonemal; dynein, axonemal, heavy polypeptide 14",
        "tax_id": 9606,
        "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); crescentic glomerulonephritis (Disease Ontology:DOID:13139); transient cerebral ischemia (Disease Ontology:DOID:224); renal carcinoma (Disease Ontology:DOID:4451); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:127602)",
        "pathway_count": 1,
        "publication_count": 35,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;23481700;24714562;24715725;25576301;25645385;27600516;28228285;28832583;28834231;29242379;29323929;29331515;30379171;30779550;31222486;31844290;32161166;32387766;32502341;32938616;33141586;33392160;33577779;33592498;33936100;33968037;33981976;34932366;35051231;35438214;35580925;36215666;38263208",
        "class_list": "",
        "function": "Circular RNA DNAH14 molecular mechanism in an experimental model of hepatocellular carcinoma treated with Cobalt chloride to mimic the hypoxia-like response of transcatheter arterial chemoembolization. Publication Status: Online-Only, [RefSeq, PubMed]; Clinical and Genetic Spectrum of Children With Primary Ciliary Dyskinesia in China., [RefSeq, PubMed]; DNAH14 variants are associated with neurodevelopmental disorders., [RefSeq, PubMed]; Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by OMIM, Mar 2008]., [RefSeq]; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)., [UniProtKB]; Genetic variants within DNAH6, DNAH14, and DNAAF3 are associated with variation in lung function among persons with cystic fibrosis., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 72,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 6,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NG62;A6NNL2;Q0VDD9;Q4VXC7;Q4VXG4;Q4VXG5;Q5VU33;Q5VU34",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding",
        "go_cellular_component": "GO:0005874 microtubule;GO:0005930 axoneme;GO:0030286 dynein complex;GO:0097729 9+2 motile cilium;GO:0005858 axonemal dynein complex",
        "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0007018 microtubule-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q0VDD8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BUQ8-1",
        "uniprot_id": "DDX23_HUMAN",
        "mass": 95583.0,
        "length": 820,
        "protein_name": "Probable ATP-dependent RNA helicase DDX23",
        "gene_name": "DDX23",
        "organism": "Human",
        "refseq_name": "probable ATP-dependent RNA helicase DDX23",
        "refseq_ac": "NP_004809",
        "gene_names_uniprotkb": "DDX23",
        "gene_names_refseq": "DDX23; PRPF28; SNRNP100; U5-100KD; U5-100K; prp28",
        "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX23; 100 kDa U5 snRNP-specific protein; 3.6.4.13; DEAD box protein 23; PRP28 homolog; U5-100kD",
        "protein_names_refseq": "100 kDa U5 snRNP-specific protein; DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; DEAD box protein 23; PRP28 homolog, yeast; PRP28p homolog; U5 snRNP 100 kD protein; U5 snRNP-specific 100-kD protein; probable ATP-dependent RNA helicase DDX23",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9416);  (R-HSA-72163);  (R-HSA-72165);  (R-HSA-9918481)",
        "pathway_count": 4,
        "publication_count": 158,
        "publication_id_list": "10207048;10882114;11014198;11101529;11233976;11237011;11333026;11607023;11747608;11991638;12176931;12411573;12414731;12477934;14519844;14625303;14713954;14762106;15084397;16314458;16723661;16809785;17081983;17095540;17332742;17606899;17940139;18322460;18425142;18593880;19007248;19052544;19103666;19165350;19536130;19651622;20068231;20423332;20858735;20980672;21406692;21536652;2176635;21911577;22110043;22365833;22959432;22961380;23222130;23236153;23345524;23481700;24196718;24304693;24448447;24737827;24914973;2524422;25418920;25555158;25576301;2558966;26030138;26092250;26385511;26420826;26811146;26929215;26969736;27108190;27377154;27459055;27510544;27683217;27846572;27920218;28062851;28063628;28076346;28076779;28228285;28502770;28781166;28832583;28904123;29242379;29301961;29360106;29361316;29393594;29493099;29508533;29557506;29632046;29632711;2963332;29786170;29902443;30315122;30315277;30429286;30484775;30599162;30705154;30728453;30765414;30975767;31092671;31154438;31409651;31530632;31844290;31848261;32119511;32157095;32161166;32179686;32265295;32329775;32387766;32494006;32502341;32522876;32938616;32983136;33177556;33214551;33243851;33446560;33717175;33912179;34019948;34229054;34301950;34561969;34822310;35051231;35215846;35385551;35580925;36284347;37217939;3757028;38665916;38743621;40914422;8566756;8608946;8835860;9016565;9242493;9409622;9512519;9524131;9539711;9671485;9701291;9731529",
        "class_list": "",
        "function": "Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; SRSF1 interactome determined by proximity labeling reveals direct interaction with spliceosomal RNA helicase DDX23. Erratum:[Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2412536121. doi: 10.1073/pnas.2412536121. PMID: 39008678], [RefSeq, PubMed]; This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R600;B4DH15;O43188",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;2.3.2.27;5.2.1.8;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.1.13.-;2.7.7.48;2.7.7.6;3.6.4.12;3.4.21.53;5.6.2.5;2.7.7.19;3.1.-.-;3.6.5.-;7.6.2.1;2.7.11.1;7.2.2.-;3.4.19.12;5.6.2.-;2.3.2.-;3.6.1.15;3.1.4.-;3.6.-.-;2.7.1.78;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;3.1.27.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0070062 extracellular exosome;GO:0000785 chromatin",
        "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0008380 RNA splicing;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 16.1,
        "record_id": "Q9BUQ8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95361-1",
        "uniprot_id": "TRI16_HUMAN",
        "mass": 63955.0,
        "length": 564,
        "protein_name": "Tripartite motif-containing protein 16",
        "gene_name": "TRIM16",
        "organism": "Human",
        "refseq_name": "tripartite motif-containing protein 16 isoform a",
        "refseq_ac": "NP_001335048",
        "gene_names_uniprotkb": "TRIM16; EBBP",
        "gene_names_refseq": "EBBP; TRIM16",
        "protein_names_uniprotkb": "Tripartite motif-containing protein 16; 2.3.2.27; E3 ubiquitin-protein ligase TRIM16; Estrogen-responsive B box protein",
        "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM16; estrogen-responsive B box protein; tripartite motif-containing protein 16 isoform a; tripartite motif-containing protein 16",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10626)",
        "pathway_count": 1,
        "publication_count": 39,
        "publication_id_list": "11237011;11919186;17081983;19651622;19664994;22629402;25576301;26992070;27693506;27846572;28510447;29557506;30143514;30418433;31844290;31848261;32157095;32387766;32488085;32938616;32983136;33392160;33592498;33968037;33981976;34087483;34171305;35051231;35230201;35318648;35580925;36010968;36180926;36241641;36284347;37477507;37938771;38581570;9817599",
        "class_list": "",
        "function": "CircPTK2 inhibits cell cisplatin (CDDP) resistance by targeting miR-942/TRIM16 axis in non-small cell lung cancer (NSCLC)., [RefSeq, PubMed]; E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage., [UniProtKB, PubMed, PubMed, PubMed]; NFKBIZ regulates NFkappaB signaling pathway to mediate tumorigenesis and metastasis of hepatocellular carcinoma by direct interaction with TRIM16. Publication Status: Online-Only, [RefSeq, PubMed]; Role in regulating keratinocyte differentiation, [RefSeq, PubMed]; TRIM16 E121D variant affects the risk and prognosis of hepatocellular carcinoma by modulating the Wnt/beta-catenin pathway., [RefSeq, PubMed]; TRIM3 and TRIM16 as potential tumor suppressors in breast cancer patients. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IAL8;Q7Z6I2;Q96BE8;Q96J43",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0019966 interleukin-1 binding;GO:0061630 ubiquitin protein ligase activity;GO:0032089 NACHT domain binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016605 PML body",
        "go_biological_process": "GO:0032526 response to retinoic acid;GO:0045893 positive regulation of DNA-templated transcription;GO:0060416 response to growth hormone;GO:0032731 positive regulation of interleukin-1 beta production;GO:0048386 positive regulation of retinoic acid receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "O95361-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14681-1",
        "uniprot_id": "EI24_HUMAN",
        "mass": 38965.0,
        "length": 340,
        "protein_name": "Etoposide-induced protein 2.4 homolog",
        "gene_name": "EI24",
        "organism": "Human",
        "refseq_name": "etoposide-induced protein 2.4 homolog isoform 3",
        "refseq_ac": "NP_001277064",
        "gene_names_uniprotkb": "EI24; PIG8",
        "gene_names_refseq": "EI24; EPG4; PIG8; TP53I8",
        "protein_names_uniprotkb": "Etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein",
        "protein_names_refseq": "ectopic P-granules autophagy protein 4 homolog; etoposide induced 2.4; etoposide-induced protein 2.4 homolog isoform 3; etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein; tumor protein p53 inducible protein 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9538)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "11237011;11753653;17081983;18669648;18691976;19413330;19651622;19664994;20058876;20068231;21154811;23186163;24275569;24715725;25418920;25576301;25892735;26154972;26992070;27541728;28038450;28228285;28467828;28904123;29493099;29632046;29769354;30315122;30784913;30833945;31217245;31844290;32357974;32387766;32897882;32938616;33298915;33392160;33717175;33912179;33968037;33981976;34109432;34171305;34357683;34405274;34509645;35051231;36215666;36241641;9305847",
        "class_list": "",
        "function": "Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity)., [UniProtKB]; EI24 is a prognostic biomarker and impacts poor outcome in non-small cell lung cancer., [RefSeq, PubMed]; EI24 is an essential player in ubiquitin-proteasome system-autophagy crosstalk via degradation of RING E3 ligases., [RefSeq, PubMed]; Low EI24 expression is associated with triple negative breast cancer., [RefSeq, PubMed]; MiR483 promotes the development of colorectal cancer by inhibiting the expression level of EI24., [RefSeq, PubMed]; This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7D6;B4DKL6;Q9BUQ1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0061676 importin-alpha family protein binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006915 apoptotic process;GO:0016236 macroautophagy;GO:0030308 negative regulation of cell growth",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "O14681-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BTE1-1",
        "uniprot_id": "DCTN5_HUMAN",
        "mass": 20127.0,
        "length": 182,
        "protein_name": "Dynactin subunit 5",
        "gene_name": "DCTN5",
        "organism": "Human",
        "refseq_name": "dynactin subunit 5 isoform 2",
        "refseq_ac": "NP_001185940",
        "gene_names_uniprotkb": "DCTN5",
        "gene_names_refseq": "DCTN5",
        "protein_names_uniprotkb": "Dynactin subunit 5; Dynactin subunit p25",
        "protein_names_refseq": "dynactin 4; dynactin 5 (p25); dynactin subunit 5 isoform 2; dynactin subunit p25",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84516);  (R-HSA-2132295);  (R-HSA-3371497);  (R-HSA-6807878);  (R-HSA-6811436)",
        "pathway_count": 5,
        "publication_count": 300,
        "publication_id_list": "10036229;10052452;10064083;10072072;10318838;10359595;10445031;10480952;10540230;10559959;10559986;10562278;10593899;10631941;10631952;10639150;10679020;10747884;10748235;10761932;10809954;10903204;10921873;11035033;11080672;11172815;11237011;11285137;11306556;11461920;11483508;11529500;11589254;11684289;11689559;11701661;11703931;11726511;11748249;11751894;11790530;11813165;11853874;12047556;12070132;12078484;12198549;12388752;12401177;12432908;12447383;12634853;12742663;12748383;12781197;12925777;13486053;14654841;14654843;14731593;14742712;1493716;15037235;15159550;15381148;15483056;15591061;15616190;15632110;15728195;15749704;15813748;15878873;15911768;15914536;16030262;16181339;16207721;16242130;1631136;16314391;16403413;16618111;16633337;16723730;1680566;16824007;16912714;16926190;16940185;17142755;17253781;17274799;17283181;17360540;17429068;17451557;17488286;17591767;17760859;17804755;17827179;17927562;17956946;18046453;18086915;18182008;18215318;18243712;18254226;18283113;18292509;18524849;18635947;18641641;18664496;18809720;1898986;19015319;19109418;19164740;19296914;19359544;1956401;19564404;1957170;19631211;19635840;19753100;19758564;20006655;20038533;20068231;20072699;20357002;20420828;20427317;20508983;20637885;21116285;21158691;21173190;21183720;2121367;21219331;21376746;21441454;21689688;21700222;21796517;21844168;2190094;22011577;22013193;22094269;22130221;22223895;22266222;22304919;22318716;22433123;22562055;22791416;23333653;23455152;23783758;23839779;2391366;24012426;24119662;24694367;24715725;24806965;24891604;25233431;25436559;25453831;25469497;25492864;25576301;25880248;26073023;26154972;26203193;26313416;26811146;26992070;27462449;27663436;27846572;28083797;28301631;28755533;28832583;28904123;28919297;29242379;29493099;29557506;29789417;30197098;30429286;31110491;31141847;31154438;31530632;31731497;31826031;31844290;31848261;32016915;32157095;32161166;32320027;32387766;32448030;32488085;32544881;32938616;32982970;32983136;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34509645;34561969;35051231;35561310;35580925;36010968;36284347;37938771;38665916;6645495;6891012;7481823;7592972;7650016;7667286;7691276;8001155;8046351;8128252;8132710;8134367;8145819;8148318;8157723;8221884;8253837;8282004;8313912;8397411;8415765;8505331;8560673;8620540;8636227;8642258;8687433;8849454;8909537;8939989;8947036;8991093;9030515;9050864;9075930;9114004;9150144;9177194;9202021;9244307;9288971;9311912;9312039;9323141;9380700;9382863;9405360;9464360;9464361;9490716;9497313;9539769;9545226;9606180;9667968;9671725;9671731;9733780;9751720;9990005",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules., [UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "glycan_count": 1,
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        "secondary_ac_list": "A8K9X8;H3BN51;H3BQA4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005869 dynactin complex;GO:0000776 kinetochore;GO:0005856 cytoskeleton",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 30.3,
        "record_id": "Q9BTE1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q08495-1",
        "uniprot_id": "DEMA_HUMAN",
        "mass": 45514.0,
        "length": 405,
        "protein_name": "Dematin",
        "gene_name": "DMTN",
        "organism": "Human",
        "refseq_name": "dematin isoform 1",
        "refseq_ac": "NP_001107607",
        "gene_names_uniprotkb": "DMTN; DMT; EPB49",
        "gene_names_refseq": "DMTN; DMT; EPB49",
        "protein_names_uniprotkb": "Dematin; Dematin actin-binding protein; Erythrocyte membrane protein band 4.9",
        "protein_names_refseq": "dematin isoform 1; erythrocyte membrane protein band 4.9 (dematin)",
        "tax_id": 9606,
        "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); developmental and epileptic encephalopathy 91 (Disease Ontology:DOID:0080472); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557)",
        "pathway": " (hsa:2039);  (R-HSA-5223345)",
        "pathway_count": 2,
        "publication_count": 76,
        "publication_id_list": "10565303;10571941;11237011;11326272;11326338;11401429;11856323;12297987;12297989;12951058;13130483;14660664;14984739;15804357;16472756;17166836;18057121;18088087;18318008;18347014;1840603;18452278;18510355;18767875;18930737;19241372;19262752;19367720;1955075;19651622;19690332;19717468;20058876;20068231;20166139;21084299;22119785;22649030;22927433;23060452;23169667;23186163;23355471;24275569;24725410;24790029;25548167;26154972;26620797;26635246;26824658;27102039;27862975;28657654;28832583;29485866;29493099;29557506;30059200;30379171;31154438;31848261;32983136;33608523;35051231;35251023;35561787;35580925;37938771;4018271;7615546;7619062;7749638;8341682;9114041;9537412",
        "class_list": "",
        "function": "Dematin inhibits glioblastoma malignancy through RhoA-mediated CDKs downregulation and cytoskeleton remodeling., [RefSeq, PubMed]; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]., [RefSeq]; When unphosphorylated, dematin's two F-actin binding domains move independent of one another permitting them to bind different F-actin filaments. Erratum:[J Biol Chem. 2015 Jul 17;290(29):17808. doi: 10.1074/jbc.A112.438861. PMID: 26188045], [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 29,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K0T5;B3KP70;B3KRH3;B4DI75;E9PEJ0;Q13215;Q9BRE3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0051015 actin filament binding;GO:0030507 spectrin binding",
        "go_cellular_component": "GO:0005790 smooth endoplasmic reticulum;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0014069 postsynaptic density",
        "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis;GO:0071320 cellular response to cAMP;GO:0030036 actin cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 8.1,
        "record_id": "Q08495-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P41970-1",
        "uniprot_id": "ELK3_HUMAN",
        "mass": 44240.0,
        "length": 407,
        "protein_name": "ETS domain-containing protein Elk-3",
        "gene_name": "ELK3",
        "organism": "Human",
        "refseq_name": "ETS domain-containing protein Elk-3 isoform 1",
        "refseq_ac": "NP_005221",
        "gene_names_uniprotkb": "ELK3; NET; SAP2",
        "gene_names_refseq": "ELK3; ERP; NET; SAP-2; SAP2",
        "protein_names_uniprotkb": "ETS domain-containing protein Elk-3; ETS-related protein ERP; ETS-related protein NET; SAP-2; SRF accessory protein 2; Serum response factor accessory protein 2",
        "protein_names_refseq": "ELK3, ETS transcription factor; ELK3, ETS-domain protein (SRF accessory protein 2); ETS domain-containing protein Elk-3 isoform 1; ETS domain-containing protein Elk-3; ETS-related protein ERP; ETS-related protein NET; SRF accessory protein 2; serum response factor accessory protein 2",
        "tax_id": 9606,
        "disease": "congenital chylothorax (Disease Ontology:DOID:0060646)",
        "pathway": " (hsa:2004)",
        "pathway_count": 1,
        "publication_count": 46,
        "publication_id_list": "11042694;11237011;15302935;18691976;19007248;23186163;24715725;25576301;26992070;27397612;27862975;28832583;28904123;29242379;29351928;29557506;29632711;29786170;30429286;31154438;31844290;31848261;32157095;32161166;32488085;32938616;32983136;33123756;33298915;33592498;33968037;34171305;34932366;35051231;35580925;36284347;36950218;37394639;37542863;37938771;38188675;38632244;40596516;7540136;7958835;9130707",
        "class_list": "",
        "function": "ELK3 Targeting AEG1 Promotes Migration and Invasion of Ovarian Cancer Cells under Hypoxia., [RefSeq, PubMed]; ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance. Publication Status: Online-Only, [RefSeq, PubMed]; ELK3-CXCL16 axis determines natural killer cell cytotoxicity via the chemotactic activity of CXCL16 in triple negative breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; ELK3-ID4 axis governs the metastatic features of triple negative breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; ETS transcription factor ELK3 in human cancers: An emerging therapeutic target. Review article, [RefSeq, PubMed]; May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element., [UniProtKB]; This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6S6;Q6FG57;Q6GU29;Q9UD17",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "P41970-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NYJ7-1",
        "uniprot_id": "DLL3_HUMAN",
        "mass": 64618.0,
        "length": 618,
        "protein_name": "Delta-like protein 3",
        "gene_name": "DLL3",
        "organism": "Human",
        "refseq_name": "delta-like protein 3 isoform 1 precursor",
        "refseq_ac": "NP_058637",
        "gene_names_uniprotkb": "DLL3",
        "gene_names_refseq": "DLL3; SCDO1",
        "protein_names_uniprotkb": "Delta-like protein 3; Delta3; Drosophila Delta homolog 3",
        "protein_names_refseq": "delta-like 3; delta-like protein 3 isoform 1 precursor; delta-like protein 3; delta3; drosophila Delta homolog 3",
        "tax_id": 9606,
        "disease": "spondylocostal dysostosis (Disease Ontology:DOID:0050568); spondylocostal dysostosis 1 (Disease Ontology:DOID:0112365); dysostosis (Disease Ontology:DOID:1934)",
        "pathway": " (hsa:10683);  (R-HSA-9793380);  (R-HSA-9824272)",
        "pathway_count": 3,
        "publication_count": 20,
        "publication_id_list": "10742114;11237011;11923214;12746394;16303743;18452278;18485326;25576301;25645385;27600516;28178531;29557506;30779550;32488085;33936100;34107132;34184566;34931456;35051231;35983951",
        "class_list": "",
        "function": "ASCL1 and DLL3 expressions and their clinicopathological implications in surgically resected pure small cell lung cancer: A study of 247 cases from the National Cancer Center of China., [RefSeq, PubMed]; DLL3 as an Emerging Target for the Treatment of Neuroendocrine Neoplasms. Review article, [RefSeq, PubMed]; Delta-like canonical Notch ligand 3 as a potential therapeutic target in malignancies: A brief overview. Review article, [RefSeq, PubMed]; Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity)., [UniProtKB]; Investigation of Candidate Genes and Pathways in Basal/TNBC Patients by Integrated Analysis., [RefSeq, PubMed]; Mutations in DLL3 cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis, [RefSeq, PubMed]; This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; We suggest that the three human DLL3 mutations associated with spondylocostal dysplasia are also functionally equivalent to the Dll3(neo) null allele in mice., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PFG2;Q8NBS4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0030154 cell differentiation;GO:0001501 skeletal system development;GO:0045746 negative regulation of Notch signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q9NYJ7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92620-1",
        "uniprot_id": "PRP16_HUMAN",
        "mass": 140503.0,
        "length": 1227,
        "protein_name": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16",
        "gene_name": "DHX38",
        "organism": "Human",
        "refseq_name": "pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16",
        "refseq_ac": "NP_054722",
        "gene_names_uniprotkb": "DHX38; DDX38; KIAA0224; PRP16",
        "gene_names_refseq": "DDX38; DHX38; PRP16; PRPF16; RP84",
        "protein_names_uniprotkb": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; 3.6.4.13; ATP-dependent RNA helicase DHX38; DEAH box protein 38",
        "protein_names_refseq": "ATP-dependent RNA helicase DHX38; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 38; DEAH (Asp-Glu-Ala-His) box polypeptide 38; DEAH box protein 38; PRP16 homolog of S.cerevisiae; pre-mRNA processing factor 16; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa 84 (Disease Ontology:DOID:0112141)",
        "pathway": " (hsa:9785);  (R-HSA-159236);  (R-HSA-72163);  (R-HSA-72187);  (R-HSA-9918481)",
        "pathway_count": 5,
        "publication_count": 228,
        "publication_id_list": "10228171;10323864;10489353;10668806;10882114;11014198;11073998;11101529;11233976;11237011;11256625;11259411;11259602;11579093;11739738;11747608;11756420;11979277;11991638;12093754;12176931;12411573;12414731;12477934;12871933;14519844;14625303;14713954;14762106;15084397;15998806;16314397;16314458;16809785;17000901;17074750;17095540;17190602;17332742;17606899;17984224;18212344;18322460;18364396;18411249;18423201;18491316;18593880;18669648;18957205;18991276;19103666;19165350;19536130;19608861;19651622;19836239;20068231;20129943;20423332;20573985;20844015;20980672;21536652;2176635;21911577;21947206;22110043;22207203;22365833;22424782;22893130;22898188;22928037;22959432;22961380;23186163;23222130;23236153;23299939;23345524;23481700;23826332;24196718;24244187;24304693;24366607;24448447;24715725;24737827;24914973;25418920;25555158;25576301;2558966;25645385;25662211;25755297;25836925;25880248;25892735;26092250;26154972;26375851;26385511;26420826;26758079;26811146;26969736;26992070;27108190;27377154;27459055;27683217;27846572;27862975;27920218;28062851;28063628;28076346;28228285;28502770;28510447;28514659;28781166;28832583;28834231;28904123;29242379;29301961;29360106;29361316;29393594;29493099;29508533;29557506;29632046;29632711;2963332;29769354;29786170;29902443;30208423;30315122;30315277;30379171;30429286;30484775;30599162;30705154;30728453;30765414;30779550;30833945;30975767;31154438;31217245;31409651;31492838;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32179686;32265295;32329775;32357974;32387766;32488085;32494006;32502341;32897882;32938616;32983136;33141586;33177556;33243851;33298915;33392160;33446560;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34301950;34405274;34509645;34725712;34822310;34932366;35051231;35215846;35318648;35385551;35561310;35580925;36010968;36215666;36241641;36284347;37217939;37506056;3757028;37931691;37938771;40914422;8566756;8608946;9016565;9242493;9512519;9524131;9539711;9618489;9660949;9671485;9701291;9731529",
        "class_list": "",
        "function": "DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. [provided by RefSeq, Jul 2008]., [RefSeq]; DHX38 enhances proliferation, metastasis, and EMT progression in NSCLC through the G3BP1-mediated MAPK pathway., [RefSeq, PubMed]; DHX38 restricts chemoresistance by regulating the alternative pre-mRNA splicing of RELL2 in pancreatic ductal adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131)., [UniProtKB, PubMed, PubMed]; Retinitis pigmentosa-linked mutation in DHX38 modulates its splicing activity. Erratum:[PLoS One. 2023 Jan 20;18(1):e0280904. doi: 10.1371/journal.pone.0280904. PMID: 36662708] Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
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        "total_o_glycosites": 2,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DVG8;D3DWS7;O75212;Q96HN7",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;2.3.2.27;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.1.13.-;2.7.7.48;2.7.7.6;3.6.4.12;3.4.21.53;5.6.2.5;2.3.2.-;2.7.7.19;3.1.-.-;3.6.5.-;7.6.2.1;5.2.1.8;7.2.2.-;5.6.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;2.7.1.78;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;3.1.27.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0034458 3'-5' RNA helicase activity;GO:0003724 RNA helicase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016020 membrane;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome",
        "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 23.2,
        "record_id": "Q92620-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z478-1",
        "uniprot_id": "DHX29_HUMAN",
        "mass": 155236.0,
        "length": 1369,
        "protein_name": "ATP-dependent RNA helicase DHX29",
        "gene_name": "DHX29",
        "organism": "Human",
        "refseq_name": "ATP-dependent RNA helicase DHX29 isoform 2",
        "refseq_ac": "NP_001332893",
        "gene_names_uniprotkb": "DHX29; DDX29",
        "gene_names_refseq": "DDX29; DHX29",
        "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX29; 3.6.4.13; DEAH box protein 29; Nucleic acid helicase DDXx",
        "protein_names_refseq": "ATP-dependent RNA helicase DHX29 isoform 2; ATP-dependent RNA helicase DHX29; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 29; DEAH (Asp-Glu-Ala-His) box polypeptide 29; DEAH box protein 29; DEAH-box helicase 29; nucleic acid helicase DDXx",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54505)",
        "pathway_count": 1,
        "publication_count": 101,
        "publication_id_list": "11237011;15302935;16964243;18669648;18767875;19109895;19413330;19651622;19664995;20018725;20058876;20068231;20877624;21406692;23186163;23481700;23706745;24366607;24715725;25418920;25576301;25645385;25880248;25892735;26154972;26375851;26811146;26992070;27067542;27600516;27733651;27846572;27920218;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29462185;29493099;29508533;29557506;29632046;29786170;29789417;30192525;30315122;30379171;30410026;30524438;30779550;30833945;31154438;31217245;31844290;31848261;31937595;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33537174;33592498;33691108;33912179;33968037;33981976;34087483;34171305;34185709;34229054;34322994;34405274;34509645;34883515;34932366;35051231;35251023;35318648;35580925;36010968;36215666;36241641;36284347;37938771;38665916;39302247",
        "class_list": "",
        "function": "5q11.2 deletion syndrome revisited-Further narrowing of the smallest region of overlap for the main clinical characteristics of the syndrome., [RefSeq, PubMed]; A critical role for DHX29 in innate immune response; molecular insights into the mechanisms by which DHX29 recognizes 5' structured EMCV RNA and interacts with MDA5 for potent type I interferon signaling and antiviral immunity. Publication Status: Online-Only, [RefSeq, PubMed]; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity., [UniProtKB, PubMed, PubMed, HAMAP]; DHX29 and eIF3 cooperate in scanning on structured mRNAs. Our findings support previous genetic data on the role of eIF3 during scanning, [RefSeq, PubMed]; DHX29 is another example of an initiation factor contributing to start codon selection., [RefSeq, PubMed]; Down-regulation of DHX29 leads to impaired translation, resulting in disassembly of polysomes and accumulation of mRNA-free 80S monomers. DHX29 depletion also impedes cancer cell growth in culture and in xenografts., [RefSeq, PubMed]; Functional role and ribosomal position of the unique N-terminal region of DHX29, a factor required for initiation on structured mammalian mRNAs., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Study reports that these 7 eIFs are not sufficient for efficient 48S complex formation on mRNAs with highly structured 5'UTRs, and that this process requires the DExH-box protein DHX29., [RefSeq, PubMed]; This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75549;Q63HN0;Q63HN3;Q8IWW2;Q8N3A1;Q9UMH2",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0045296 cadherin binding;GO:0043024 ribosomal small subunit binding",
        "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0022627 cytosolic small ribosomal subunit",
        "go_biological_process": "GO:0001731 formation of translation preinitiation complex;GO:0042255 ribosome assembly;GO:0045948 positive regulation of translational initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.4,
        "record_id": "Q7Z478-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43812-1",
        "uniprot_id": "DUX1_HUMAN",
        "mass": 19347.0,
        "length": 170,
        "protein_name": "Double homeobox protein 1",
        "gene_name": "DUX1",
        "organism": "Human",
        "refseq_name": "double homeobox protein 1",
        "refseq_ac": "NP_036278",
        "gene_names_uniprotkb": "DUX1",
        "gene_names_refseq": "DUX1",
        "protein_names_uniprotkb": "Double homeobox protein 1",
        "protein_names_refseq": "double homeobox protein 1",
        "tax_id": 9606,
        "disease": "myocardial infarction (Disease Ontology:DOID:5844)",
        "pathway": " (hsa:26584)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "15709750;35051231;9736770",
        "class_list": "",
        "function": "Probable transcription activator. Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'., [UniProtKB, PubMed]; Report shows that full-length DUX1 is actively transported into the nuclei of transfected C2C12 myoblasts, and that DUX1 homeodomains contain the signals required for this localization., [RefSeq, PubMed]; The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUX gene family, including DUX1, resides within these 3.3-kb repeated elements (Beckers et al., 2001 [PubMed 11245978]). See DUX4 (MIM 606009).[supplied by OMIM, Mar 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "O43812-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6RFH8-1",
        "uniprot_id": "DUX4C_HUMAN",
        "mass": 39442.0,
        "length": 374,
        "protein_name": "Double homeobox protein 4C",
        "gene_name": "DUX4L9",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DUX4L9; DUX4C",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Double homeobox protein 4C; DUX4c; Double homeobox protein 4, centromeric; Double homeobox protein 4-like protein 9",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 7,
        "publication_id_list": "18723017;19829708;24145033;26816005;29329560;36158201;36882853",
        "class_list": "",
        "function": "Down-regulates MYOD1 expression and may up-regulate MYF5 expression (PubMed:19829708). May regulate microRNA (miRNA) transcription, up-regulating the expression of some myogenic miRNAs, including MIR1-1, MIR133A2, MIR133B and MIR206 (PubMed:24145033). Impairs the differentiation of myoblasts and may be involved in muscle regeneration (PubMed:18723017, PubMed:36882853). Reduces DUX4-induced nuclear localization of CTNNB1/beta-catenin and its subsequent activation of target genes (PubMed:36158201)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010468 regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q6RFH8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5JSZ5-1",
        "uniprot_id": "PRC2B_HUMAN",
        "mass": 242967.0,
        "length": 2229,
        "protein_name": "Protein PRRC2B",
        "gene_name": "PRRC2B",
        "organism": "Human",
        "refseq_name": "protein PRRC2B isoform 1",
        "refseq_ac": "NP_037450",
        "gene_names_uniprotkb": "PRRC2B; BAT2L1; BAT2L; KIAA0515",
        "gene_names_refseq": "BAT2L1; BAT2L; KIAA0515; LQFBS-1; PRRC2B",
        "protein_names_uniprotkb": "Protein PRRC2B; HLA-B-associated transcript 2-like 1; Proline-rich coiled-coil protein 2B",
        "protein_names_refseq": "HLA-B associated transcript 2-like; HLA-B-associated transcript 2-like 1; proline-rich coiled-coil protein 2B; protein BAT2-like 1; protein PRRC2B isoform 1; protein PRRC2B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84726)",
        "pathway_count": 1,
        "publication_count": 131,
        "publication_id_list": "11237011;16964243;17081983;18212344;18220336;18318008;18452278;18669648;18691976;19007248;19413330;19651622;19664995;19690332;20068231;20166139;21406692;22645359;22661428;23186163;23301498;23481700;24715725;25418920;25505266;25576301;25645385;25772364;26154972;26375851;26811146;26992070;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28314751;28514659;28604694;28657654;28832583;28834231;28904123;29237092;29242379;29331515;29351928;29393594;29437277;29485866;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30059200;30315122;30379171;30410026;30429286;30484775;30524438;30620550;30833945;31154438;31217245;31492838;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32265295;32357974;32387766;32502341;32574038;32897882;32938616;32938750;33141586;33214551;33298915;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;34019948;34087483;34171305;34211107;34405274;34509645;34561969;34846842;34932366;35051231;35132862;35138101;35254053;35289036;35494241;35513511;35580925;35705054;36010968;36215666;36241641;36284347;37125639;37340703;37541260;37938771;38348310;38665916;38838015;39531497;39534244;40307207",
        "class_list": "",
        "function": "Identification and Characterization of a ceRNA Regulatory Network Involving LINC00482 and PRRC2B in Peripheral Blood Mononuclear Cells: Implications for COPD Pathogenesis and Diagnosis. Publication Status: Online-Only, [RefSeq, PubMed]; RNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 10,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 10,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 10,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 36,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 69,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60270;Q5JSZ7;Q66VZ2;Q68CR0;Q96EI9;Q9H683",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "",
        "go_biological_process": "GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.4,
        "record_id": "Q5JSZ5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O76075-1",
        "uniprot_id": "DFFB_HUMAN",
        "mass": 39110.0,
        "length": 338,
        "protein_name": "DNA fragmentation factor subunit beta",
        "gene_name": "DFFB",
        "organism": "Human",
        "refseq_name": "DNA fragmentation factor subunit beta isoform 4",
        "refseq_ac": "NP_001307061",
        "gene_names_uniprotkb": "DFFB; CAD; DFF2; DFF40",
        "gene_names_refseq": "CAD; CPAN; DFF-40; DFF2; DFF40; DFFB",
        "protein_names_uniprotkb": "DNA fragmentation factor subunit beta; 3.-.-.-; CAD; CPAN; Caspase-activated DNase; Caspase-activated deoxyribonuclease; Caspase-activated nuclease; DFF-40; DNA fragmentation factor 40 kDa subunit",
        "protein_names_refseq": "DNA fragmentation factor 40 kDa subunit; DNA fragmentation factor subunit beta isoform 4; DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); caspase-activated DNase; caspase-activated deoxyribonuclease; caspase-activated nuclease",
        "tax_id": 9606,
        "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); glycogen storage disease (Disease Ontology:DOID:2747); Lafora disease (Disease Ontology:DOID:3534)",
        "pathway": " (hsa:1677);  (R-HSA-140342)",
        "pathway_count": 2,
        "publication_count": 47,
        "publication_id_list": "10318789;10713148;10830907;11237011;11371636;12748178;14759258;15149602;15569692;15910001;17938174;18239742;18283539;19882353;24715725;25576301;26992070;27600516;27893789;28218747;28228285;28834231;29557506;29632046;31844290;32357974;32387766;32488085;32938616;33141586;33298915;33968037;34006390;34171305;34405274;34509645;34678222;35051231;35393399;36010968;36241641;37215747;40596516;9108473;9560346;9671700;9689044",
        "class_list": "",
        "function": "Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013]., [RefSeq]; DFF40 deficiency in cancerous T cells is implicated in chemotherapy drug sensitivity and resistance through the regulation of the apoptotic pathway., [RefSeq, PubMed]; MEG3 Regulates CSE-Induced Apoptosis by Regulating miR-421/DFFB Signal Axis. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology., [UniProtKB, UniProtKB, UniProtKB]; Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse. Publication Status: Online-Only, [RefSeq, PubMed]; The Nexus of cfDNA and Nuclease Biology. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60521;Q5SR22;Q9BYI4;Q9BYI5;Q9BYI6",
        "ec_number_list": "3.-.-.-;3.4.22.56",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0016787 hydrolase activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0004520 DNA endonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0030263 apoptotic chromosome condensation;GO:0006309 apoptotic DNA fragmentation;GO:0006308 DNA catabolic process;GO:1902511 negative regulation of apoptotic DNA fragmentation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "O76075-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P02794-1",
        "uniprot_id": "FRIH_HUMAN",
        "mass": 21226.0,
        "length": 183,
        "protein_name": "Ferritin heavy chain",
        "gene_name": "FTH1",
        "organism": "Human",
        "refseq_name": "ferritin heavy chain",
        "refseq_ac": "NP_002023",
        "gene_names_uniprotkb": "FTH1; FTHL6; FTH; PIG15; SW-cl.84",
        "gene_names_refseq": "FHC; FTH1; FTHL6; FTH; HFE5; NBIA9; PIG15; PLIF",
        "protein_names_uniprotkb": "Ferritin heavy chain; 1.16.3.1; Cell proliferation-inducing gene 15 protein; Ferritin H subunit",
        "protein_names_refseq": "H-ferritin; apoferritin; cell proliferation-inducing gene 15 protein; ferritin H subunit; ferritin heavy chain; ferritin, heavy polypeptide 1; placenta immunoregulatory factor; proliferation-inducing protein 15",
        "tax_id": 9606,
        "disease": "COVID-19 (Disease Ontology:DOID:0080600); neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734); hemochromatosis type 5 (Disease Ontology:DOID:0111031); candidiasis (Disease Ontology:DOID:1508); alcohol use disorder (Disease Ontology:DOID:1574); squamous cell carcinoma (Disease Ontology:DOID:1749); rectum cancer (Disease Ontology:DOID:1993); basal cell carcinoma (Disease Ontology:DOID:2513); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); multiple myeloma (Disease Ontology:DOID:9538); neurodegeneration with brain iron accumulation 9 (MONDO:MONDO:0958012)",
        "pathway": " (hsa:2495);  (R-HSA-3000480);  (R-HSA-432722);  (R-HSA-6798695);  (R-HSA-917937)",
        "pathway_count": 5,
        "publication_count": 180,
        "publication_id_list": "10.1101/2023.09.13.557529;10224290;10394364;10597293;10651831;10686426;10722588;11237011;11323407;11389486;11564734;11590181;11604418;11694590;11820786;11994746;12453412;12488451;12504026;12761161;12763022;12847263;12958161;1339697;14576842;14609958;15001581;15044468;15102850;15201052;15302935;15531878;15537541;16143108;16155256;16237101;16274220;16377569;16407072;16510471;16525990;16882874;16926412;16964243;16984918;17081983;17116749;17179669;17332894;17709607;18194661;18318008;18452278;1852209;18669648;19073604;19227971;1946430;19651622;19762596;19762597;19911804;1992356;20068231;20166139;20230923;20360967;20550936;20810988;20849212;20888598;20956340;21406692;2154449;21782039;2251254;22570530;2318890;23197261;23481700;23615448;23650620;24190977;24275569;24695223;24714562;25502872;25645385;26436293;26992070;27600516;28218747;28514659;28832583;28834231;28904123;29242379;29314611;29437277;29557506;29769354;29786170;3003694;30192525;3020541;3023856;30429286;30484775;30573663;30779550;31020640;31530632;31844290;31848261;32157095;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33043033;33298915;33349241;33465208;33592498;33691108;33912179;33936100;33968037;34078123;34357683;34433824;34509645;3467373;34932366;35051231;35154160;35251023;35504898;35580925;36010968;36215666;36241641;36284347;37074911;37217939;37660254;37938771;3840162;38609896;38738555;39294443;40596516;40961600;6088540;6255257;6323167;6589621;7607209;7916709;7983023;8041788;8127896;8374173;8429030;8524399;8670264;8692836;8695634;8751442;8784195;9003196;9159481;9225214;9465098;9468508;9511720;9548586",
        "class_list": "",
        "function": "Crosstalk between FTH1 and PYCR1 dysregulates proline metabolism and mediates cell growth in KRAS-mutant pancreatic cancer cells. Erratum:[Exp Mol Med. 2025 Mar;57(3):700-701. doi: 10.1038/s12276-025-01437-w. PMID: 40148571], [RefSeq, PubMed]; FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation. Publication Status: Online-Only, [RefSeq, PubMed]; METTL14 decreases FTH1 mRNA stability via m6A methylation to promote sorafenib-induced ferroptosis of cervical cancer., [RefSeq, PubMed]; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (PubMed:24695223, PubMed:26436293)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "monitoring",
        "glycan_count": 3,
        "disease_count": 13,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KNR5;Q3KRA8;Q3SWW1",
        "ec_number_list": "1.8.3.2;3.4.19.12;3.6.4.13;1.1.1.42;1.11.1.27;1.16.3.1;1.11.1.9;1.16.3.4;2.4.2.1;3.4.21.46;3.4.21.-;1.11.1.6;4.1.2.13;2.4.1.1;5.3.1.9;5.1.3.-;3.4.23.5;3.4.22.52;3.4.22.1;3.6.4.10;3.2.1.31;2.5.1.18;1.13.11.-;1.13.11.34;3.3.2.6;3.4.11.4;1.1.1.205;4.2.99.18;5.6.2.4;3.6.5.-;4.2.1.24;3.4.19.1;5.3.2.1;5.3.3.12;2.7.10.2;2.7.11.1;2.7.1.40;3.4.24.35;3.1.6.14;3.1.6.12;3.2.1.23;2.7.1.11;5.4.2.11;5.4.2.4;2.7.4.6;2.7.13.3;3.4.24.34;3.4.22.27;2.7.11.24;3.1.3.48;3.5.4.5;3.4.21.4;5.4.2.2;2.4.1.186;3.6.1.-;2.7.1.1;2.7.1.-;2.3.3.8;3.6.4.6;3.2.1.17;5.2.1.8;3.1.1.47;3.1.1.-;3.5.4.6;1.11.1.24;3.2.1.14;3.5.1.23;3.5.1.-;3.5.1.109;2.7.11.22;2.7.11.23;2.3.2.5;2.3.2.26;3.6.1.6;3.4.19.9;5.4.2.7;3.4.25.1;2.1.1.348;2.1.1.9;3.5.1.3;2.3.2.27;3.4.18.1;4.1.2.4",
        "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0008198 ferrous iron binding;GO:0004322 ferroxidase activity;GO:0008199 ferric iron binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006955 immune response;GO:0008285 negative regulation of cell population proliferation;GO:0006879 intracellular iron ion homeostasis;GO:0048147 negative regulation of fibroblast proliferation;GO:0006826 iron ion transport",
        "synthesized_glycan_count": 0,
        "hit_score": 18.7,
        "record_id": "P02794-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95163-1",
        "uniprot_id": "ELP1_HUMAN",
        "mass": 150254.0,
        "length": 1332,
        "protein_name": "Elongator complex protein 1",
        "gene_name": "ELP1",
        "organism": "Human",
        "refseq_name": "elongator complex protein 1 isoform 2",
        "refseq_ac": "NP_001305289",
        "gene_names_uniprotkb": "ELP1; IKAP; IKBKAP",
        "gene_names_refseq": "DYS; ELP1; FD; IKAP; IKBKAP; IKI3; TOT1",
        "protein_names_uniprotkb": "Elongator complex protein 1; ELP1; IKK complex-associated protein; IkappaB kinase complex-associated protein; p150",
        "protein_names_refseq": "IKK complex-associated protein; elongator complex protein 1 isoform 2; elongator complex protein 1; ikappaB kinase complex-associated protein; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein",
        "tax_id": 9606,
        "disease": "hemophagocytic lymphohistiocytosis (Disease Ontology:DOID:0050120); medulloblastoma (Disease Ontology:DOID:0050902); scoliosis (Disease Ontology:DOID:0060249); familial dysautonomia (Disease Ontology:DOID:11589); asthma (Disease Ontology:DOID:2841); kyphosis (Disease Ontology:DOID:4667)",
        "pathway": " (hsa:8518);  (R-HSA-3214847)",
        "pathway_count": 2,
        "publication_count": 92,
        "publication_id_list": "10786633;10821277;11179008;11179021;11237011;11714725;11818576;12687659;15313887;16387653;18381289;18623064;18669648;19187765;20018852;20068231;22854966;23186163;23301498;23481700;24366607;24715725;25576301;25645385;25880248;25892735;25960406;26154972;26261306;26375851;26811146;26992070;27600516;27846572;28218747;28510447;28514659;28832583;28904123;29242379;29332244;29437277;29493099;29508533;29557506;29786170;30315122;30397120;30410026;31611695;31844290;32157095;32296180;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33633747;33691108;33717175;33912179;33968037;33981976;34087483;34171305;34185709;34211107;34229054;34357683;34509645;34932366;35051231;35580925;36010968;36241641;36284347;36580660;37938771;38665916;38829854;39138000;39531497;9427644;9558366;9751059;9880483",
        "class_list": "",
        "function": "Age-dependent regulation of ELP1 exon 20 splicing in Familial Dysautonomia by RNA Polymerase II kinetics and chromatin structure. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; ELP1, the Gene Mutated in Familial Dysautonomia, Is Required for Normal Enteric Nervous System Development and Maintenance and for Gut Epithelium Homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]., [RefSeq]; Tumours from patients with ELP1-associated medulloblastoma subgroup Sonic Hedgehog were characterized by a destabilized Elongator complex, loss of Elongator-dependent tRNA modifications, codon-dependent translational reprogramming, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JSV2;Q9H327;Q9UG87",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000049 tRNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0033588 elongator holoenzyme complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0006417 regulation of translation;GO:0002098 tRNA wobble uridine modification;GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation",
        "synthesized_glycan_count": 0,
        "hit_score": 9.6,
        "record_id": "O95163-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7L2H7-1",
        "uniprot_id": "EIF3M_HUMAN",
        "mass": 42503.0,
        "length": 374,
        "protein_name": "Eukaryotic translation initiation factor 3 subunit M",
        "gene_name": "EIF3M",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 3 subunit M isoform 2",
        "refseq_ac": "NP_001294858",
        "gene_names_uniprotkb": "EIF3M; GA17; HFLB5; PCID1; PNAS-125",
        "gene_names_refseq": "B5; EIF3M; GA17; PCID1; TANGO7; hfl-B5",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit M; Fetal lung protein B5; PCI domain-containing protein 1; eIF3m; hFL-B5",
        "protein_names_refseq": "B5 receptor; PCI domain containing 1 (herpesvirus entry mediator); PCI domain-containing protein 1; dendritic cell protein; eukaryotic translation initiation factor 3 subunit M isoform 2; fetal lung protein B5; transport and golgi organization 7 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10480);  (R-HSA-156827);  (R-HSA-72649);  (R-HSA-72689);  (R-HSA-72695);  (R-HSA-72702);  (R-HSA-72706)",
        "pathway_count": 7,
        "publication_count": 134,
        "publication_id_list": "10364207;10659855;1095581;11018020;1104615;11237011;12493757;12588972;14567916;15592455;15601822;15703437;15904532;15919898;15919899;16766523;16959974;17322308;17403899;17719568;17924679;18491316;1856230;18599441;19608861;19664994;19664995;21406692;21872626;23186163;23301498;24366607;24714562;24715725;25505266;25576301;25645385;25810538;25849773;25892735;26154972;26992070;27462815;27543614;27600516;27846572;27920218;28218747;28228285;28467828;28510447;28514659;28832583;28834231;28855257;28904123;29242379;29331515;29437277;29493099;29508533;29557506;29786170;30315122;30410026;30429286;30484775;30524438;30779550;30833945;31092671;31154438;31217245;31222486;31530632;31844290;31848261;31937595;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33465208;33537174;33592498;33691108;33717175;33912179;33936100;33968037;34087483;34171305;34211107;34357683;34405274;34509645;34725712;34932366;35051231;35154160;35251023;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37938771;38665916;39302247;40307207;40596516;40914422;429297;592398;592399;641056;6853548;6901506;7000367;8943342;9045610;9732867;9857202",
        "class_list": "",
        "function": "(Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2)., [UniProtKB, PubMed]; Cloned a previously uncharacterized human gene, designated hfl-B5, and showed that it encodes a type II cell surface membrane protein that can serve as a receptor for entry of HSV., [RefSeq, PubMed]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed]; Concluded that the C terminus of B5 contains a functional region that is important for the B5 receptor to mediate events in HSV entry., [RefSeq, PubMed]; This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7X4;B4E2Q4;O60735;Q2F836;Q53HL6;Q9BXW1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m;GO:0005852 eukaryotic translation initiation factor 3 complex",
        "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex",
        "synthesized_glycan_count": 0,
        "hit_score": 14.0,
        "record_id": "Q7L2H7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15306-1",
        "uniprot_id": "IRF4_HUMAN",
        "mass": 51772.0,
        "length": 451,
        "protein_name": "Interferon regulatory factor 4",
        "gene_name": "IRF4",
        "organism": "Human",
        "refseq_name": "interferon regulatory factor 4 isoform 2",
        "refseq_ac": "NP_001182215",
        "gene_names_uniprotkb": "IRF4; MUM1",
        "gene_names_refseq": "IMD131; IRF4; LSIRF; MUM1; NF-EM5; SHEP8",
        "protein_names_uniprotkb": "Interferon regulatory factor 4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1; NF-EM5",
        "protein_names_refseq": "interferon regulatory factor 4 isoform 2; lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1",
        "tax_id": 9606,
        "disease": "anaplastic large cell lymphoma (Disease Ontology:DOID:0050744); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); peripheral T-cell lymphoma (Disease Ontology:DOID:0050749); follicular lymphoma (Disease Ontology:DOID:0050873); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); immunodeficiency 131 (Disease Ontology:DOID:0061125); pigmentation disease (Disease Ontology:DOID:10123); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); leukemia (Disease Ontology:DOID:1240); dilated cardiomyopathy (Disease Ontology:DOID:12930); middle cerebral artery infarction (Disease Ontology:DOID:3525); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:3662);  (R-HSA-6785807);  (R-HSA-877300);  (R-HSA-909733);  (R-HSA-9725371);  (R-HSA-9824585);  (R-HSA-9976102)",
        "pathway_count": 7,
        "publication_count": 334,
        "publication_id_list": "10023775;10067896;10196196;10219247;10369418;10395669;10510379;10542297;10586089;10587587;10867011;10982844;10986460;11058569;11084045;11092454;11104795;11120780;11169414;11237011;11278437;11278729;11337497;11356008;11377645;11404376;11404481;11463377;11532965;11585831;11751994;11856727;11960372;11964381;11972023;12029096;12040185;12062444;12223527;12242343;12438563;12446674;12600988;12651066;12748172;12766484;12832402;12842042;12915721;1321344;1396683;14586410;14634100;14712222;14722222;14769151;15047845;1508672;15116091;15143187;15261459;15312780;15322115;1537333;1537334;15388922;15449939;15530433;15543135;15584925;15695812;15729346;15778442;15805299;15869882;15950906;16007214;16009132;16009940;16048438;16107692;16171819;16205632;16236134;16237089;16303920;16397018;16451196;16467876;16510571;16540365;16606674;16987978;17110082;17111047;17125875;17182843;17251292;1730654;17351669;17416736;17427945;17458857;17572495;17690253;17922009;17952075;17969444;18024471;18035202;18097461;18243101;18353781;18362138;18446792;18447642;18483556;18575461;18591661;18644974;18697795;18812475;18991276;19124156;19185846;19389701;19397496;19717472;19901323;20015877;20049711;20130243;20304997;20363976;20493732;20643137;20697158;21102457;21252155;21689689;21715655;21730069;21872626;21937440;21993680;21994466;22046235;2211721;22205702;22383755;22424782;22645359;22693070;22851691;22955283;23061660;23086340;23121362;23124025;23172665;23455323;23481700;23555662;23967200;24060861;24097101;24267888;24366607;24417533;24714562;24715725;24743777;25234944;25371710;25418920;25469497;25502872;25576301;25645385;25818168;25880248;25892735;26154972;26375851;26694611;26728094;26811146;26929215;26992070;27553022;27600516;27920218;28063628;28218747;28228285;28446606;28832583;28834231;28904123;29242379;29393594;29408330;29437277;29493099;29508533;29537367;29557506;29588546;29632046;29632711;29786170;30315122;30379171;30410026;30485383;30515787;30524438;30692217;31092671;31217245;31366041;31390744;31434245;31530632;31844290;31937595;31998317;32032529;32113509;32157095;32350084;32357974;32502341;32511913;32574262;32661006;32758689;32862111;32897882;32983136;33091337;33100333;33117408;33141586;33189161;33193462;33239784;33298915;33392160;33396578;33633747;33691108;33717175;33912179;33936100;34078123;34211107;34357683;34561969;34932366;35051231;35154160;35580127;35580925;36284347;36581221;36662884;36917008;37809068;37876327;37935654;38943641;39051937;39894887;6162102;6548414;688397;7510216;7512451;7514165;7526154;7529288;7530745;7537377;7540766;7615558;7617032;7657660;7673114;7690989;7795521;7796299;7796300;7813420;7898939;7907877;8085155;8156998;8176225;8197134;8232552;8306979;8483949;8530158;8550631;8602263;8605876;8621447;8621622;8631301;8663118;8668165;8702790;8797861;8816495;8921401;9013879;9096384;9111318;9121453;9143706;9242679;9326949;9334213;9651359;9660177;9723655;9736340;9758418;9822675;9847332;9861020;9874564;9930702",
        "class_list": "",
        "function": "Clinical boundaries in adult cases of large B cell lymphoma with IRF4 rearrangement., [RefSeq, PubMed]; Human inborn errors of immunity associated with IRF4. Review article Publication Status: Online-Only, [RefSeq, PubMed]; IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression., [RefSeq, PubMed]; Interferon-induced protein 44 (IFI44) and interferon regulatory factor 4 (IRF4) gene expression in rheumatoid arthritis., [RefSeq, PubMed]; The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]., [RefSeq]; Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes., [UniProtKB, PubMed, PubMed, PubMed]; Transcriptional reprogramming by mutated IRF4 in lymphoma. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 13,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VUI7;Q99660",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0045622 regulation of T-helper cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 33.7,
        "record_id": "Q15306-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13232-1",
        "uniprot_id": "NDKC_HUMAN",
        "mass": 19015.0,
        "length": 169,
        "protein_name": "Nucleoside diphosphate kinase C",
        "gene_name": "NME3",
        "organism": "Human",
        "refseq_name": "nucleoside diphosphate kinase C precursor",
        "refseq_ac": "NP_002504",
        "gene_names_uniprotkb": "NME3",
        "gene_names_refseq": "DR-nm23; NDK3; NDPK-C; NDPKC; NM23-H3; NM23H3; NME3; c371H6.2",
        "protein_names_uniprotkb": "Nucleoside diphosphate kinase C; 2.7.4.6; DR-nm23; NDK3; NDPK-C; Nucleoside diphosphate kinase 3; nm23-H3",
        "protein_names_refseq": "NDK 3; NDP kinase 3; NDP kinase C; non-metastatic cells 3, protein expressed in; nucleoside diphosphate kinase 3; nucleoside diphosphate kinase C precursor; nucleoside diphosphate kinase C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4832);  (R-HSA-499943)",
        "pathway_count": 2,
        "publication_count": 108,
        "publication_id_list": "10215863;10453732;10618642;10716435;10799505;10884394;10899599;11042679;11237011;11277919;11278511;11517226;11796141;11912132;12972261;13211603;14729598;15630091;16179339;16373698;16756507;16820675;17320107;177353;17824959;18469;1851158;18635542;18991276;18997010;19176520;19220460;19766732;21080915;211388;211390;22544926;22847445;23416111;23481700;25418920;2542324;25576301;25645385;2656695;2668278;26945015;26992070;28063628;28218747;28228285;28514659;28832583;29242379;29331515;29393594;29437277;29493099;29557506;29632046;30111592;30315122;30429286;30524438;30587587;30833945;31154438;31844290;31848261;32157095;32161166;32357974;32387766;32897882;32938616;32983136;33141586;33298915;33633747;33717175;33968037;33981976;34087483;34171305;34357683;34509645;34561969;34932366;35051231;35251023;35561310;35580925;36284347;36522796;37584589;37938771;39337255;40615;5484814;6182143;6248551;7638209;7685356;7851394;8448179;8663313;9488696;9677297",
        "class_list": "",
        "function": "Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:11277919, PubMed:30587587, PubMed:39337255). In vitro, can also use other phosphate donors such as UTP and GTP (PubMed:30587587, PubMed:39337255). Independently of its nucleoside diphosphate kinase activity, involved in mitochondrial membrane tethering, a prerequisite for fusion through direct membrane-binding and hexamerization (PubMed:30587587, PubMed:37584589). Involved in DNA repair of both single- and double-stranded breaks by associating with the ribonucleotide reductase (RNR) complex via interaction with the histone acetyltransferase KAT5, facilitating recruitment to DNA damage sites independently of its kinase activity (PubMed:26945015). Inhibits granulocyte differentiation (PubMed:7638209). May be required for ciliary function during renal development (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Genetic defects in peroxisome morphogenesis (Pex11beta, dynamin-like protein 1, and nucleoside diphosphate kinase 3) affect docosahexaenoic acid-phospholipid metabolism., [RefSeq, PubMed]; Mechanistic Insights into Substrate Recognition of Human Nucleoside Diphosphate Kinase C Based on Nucleotide-Induced Structural Changes. Publication Status: Online-Only, [RefSeq, PubMed]; NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BWH4",
        "ec_number_list": "2.7.4.10;2.7.4.6;2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.4.3;2.7.4.4;2.7.11.23;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.7.4.14;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043531 ADP binding;GO:0019003 GDP binding;GO:0070300 phosphatidic acid binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0036064 ciliary basal body",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006915 apoptotic process;GO:0008053 mitochondrial fusion;GO:0034214 protein hexamerization;GO:0006183 GTP biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 10.9,
        "record_id": "Q13232-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86UT6-1",
        "uniprot_id": "NLRX1_HUMAN",
        "mass": 107616.0,
        "length": 975,
        "protein_name": "NLR family member X1",
        "gene_name": "NLRX1",
        "organism": "Human",
        "refseq_name": "NLR family member X1 isoform 1 precursor",
        "refseq_ac": "NP_001269072",
        "gene_names_uniprotkb": "NLRX1; NOD5; NOD9",
        "gene_names_refseq": "CLR11.3; DLNB26; NLRX1; NOD26; NOD5; NOD9",
        "protein_names_uniprotkb": "NLR family member X1; CLR11.3; Caterpiller protein 11.3; Nucleotide-binding oligomerization domain protein 5; Nucleotide-binding oligomerization domain protein 9",
        "protein_names_refseq": "NLR family member X1 isoform 1 precursor; NOD-like receptor X1; caterpiller protein 11.3; nucleotide-binding oligomerization domain protein 26; nucleotide-binding oligomerization domain protein 5; nucleotide-binding oligomerization domain protein 9; nucleotide-binding oligomerization domain, leucine rich repeat containing X1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79671);  (R-HSA-168928);  (R-HSA-936440);  (R-HSA-9758274)",
        "pathway_count": 4,
        "publication_count": 61,
        "publication_id_list": "11237011;12766759;15208624;15389287;15771576;15952891;16125763;16127453;16153868;16394098;16699525;16715065;17392790;17600090;17991829;18057259;18200010;18219313;18307765;18397740;18466630;18591409;19017631;19125153;19484123;19531363;19692591;19881509;19893624;20304918;20403326;20434986;20628368;21703539;22386589;22749352;24755855;24799673;25576301;26240016;26620909;27393910;27426725;28832583;28860189;29242379;29557506;29632046;30429286;31826938;32357974;33654074;34171305;34932366;35051231;35513753;36617838;37574163;38683455;38891045;39894887",
        "class_list": "",
        "function": "Function of NOD-like receptors in the antiviral response [REVIEW] Review article Publication Status: Online-Only, [RefSeq, PubMed]; Identification of NLRX1 as a check against mitochondrial antiviral responses--an intersection of three ancient cellular processes: NLR signalling, intracellular virus detection and the use of mitochondria as a platform for anti-pathogen signalling, [RefSeq, PubMed]; NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused by Porcine Astrovirus Infection via the Extracellular Regulated Protein Kinases/Myosin Light-Chain Kinase (ERK/MLCK) Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; NLRX1 has a functional leader sequence and fully translocates to the mitochondrial matrix., [RefSeq, PubMed]; NLRX1 increases human retinal pigment epithelial autophagy and reduces H2O2-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation. Publication Status: Online-Only, [RefSeq, PubMed]; NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy. Review article, [RefSeq, PubMed]; NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Sequesters MAVS away from RIG-I and thereby prevents mitochondrial anti-viral immunity, [RefSeq, PubMed]; The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]., [RefSeq]; These results identify NLRX1 as a NLR that contributes to the link between reactive oxygen species generation at the mitochondria and innate immune responses., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
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        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6Q1;B3KPK2;B3KTA2;Q7RTR3;Q96D51;Q9H724",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol",
        "go_biological_process": "GO:0045087 innate immune response;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0039536 negative regulation of RIG-I signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 6.4,
        "record_id": "Q86UT6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NRR4-1",
        "uniprot_id": "RNC_HUMAN",
        "mass": 159316.0,
        "length": 1374,
        "protein_name": "Ribonuclease 3",
        "gene_name": "DROSHA",
        "organism": "Human",
        "refseq_name": "ribonuclease 3 isoform 2",
        "refseq_ac": "NP_001093882",
        "gene_names_uniprotkb": "DROSHA; RN3; RNASE3L; RNASEN",
        "gene_names_refseq": "DROSHA; ETOHI2; HSA242976; RANSE3L; RN3; RNASE3L; RNASEN",
        "protein_names_uniprotkb": "Ribonuclease 3; 3.1.26.3; Protein Drosha; RNase III; Ribonuclease III; p241",
        "protein_names_refseq": "drosha, double-stranded RNA-specific endoribonuclease; nuclear RNase III Drosha; putative protein p241 which interacts with transcription factor Sp1; putative ribonuclease III; ribonuclease 3 isoform 2; ribonuclease 3; ribonuclease type III, nuclear",
        "tax_id": 9606,
        "disease": "brain disease (Disease Ontology:DOID:936)",
        "pathway": " (hsa:29102);  (R-HSA-203927)",
        "pathway_count": 2,
        "publication_count": 141,
        "publication_id_list": "10948199;10976766;11201747;11237011;11452083;12411504;12411505;14508493;14631048;14681208;14730017;15284456;15364901;15372072;15525708;15531877;15565168;15574589;15589161;15973356;16142218;16271386;16357216;16424907;16751099;16906129;17057362;17081983;17099701;17159994;17452327;17531811;17932509;18178619;18491316;18632581;18728384;18782830;18842624;19401777;19651622;19966796;20068231;20226070;20554852;21406692;21674040;21726814;22106413;22118463;22163034;22544926;22844086;23063121;23063653;23186163;23251028;23481700;23511973;23531496;23624860;23661684;24715725;25326327;25418920;25568082;25576301;25645385;25793518;25892735;26027739;26748718;26992070;27846572;27862975;27907888;27920218;28218747;28228285;28514659;28832583;28834231;28855257;28904123;29242379;29508533;29557506;29632711;29769354;30315122;30410026;30429286;30484775;30524438;30779550;31154438;31217245;31222486;31819270;31844290;31848261;31937595;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34509645;34561969;34932366;35051231;35494241;35580925;36010968;36215666;36241641;36911928;36983035;37099569;37938771;38241848;39531497",
        "class_list": "",
        "function": "Association of DROSHA rs6877842, rs642321 and rs10719 polymorphisms with increased susceptibility to breast cancer: A case-control study with genotype and haplotype analysis., [RefSeq, PubMed]; Cytoplasmic and nuclear DROSHA in human villous trophoblasts., [RefSeq, PubMed]; Downregulation of DROSHA: Could It Affect miRNA Biogenesis in Endometriotic Menstrual Blood Mesenchymal Stem Cells? Publication Status: Online-Only, [RefSeq, PubMed]; Identification of another RNase III, human Drosha, as the core nuclease that executes the initiation step of miRNA processing in the nucleus, [RefSeq, PubMed]; Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The 3' UTR polymorphisms rs3742330 in DICER1 and rs10719 in DROSHA genes are not associated with primary open-angle and angle-closure glaucoma: As case-control study. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 19,
        "reported_glycation": 0,
        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E7EMP9;Q7Z5V2;Q86YH0;Q9NW73;Q9Y2V9;Q9Y4Y0",
        "ec_number_list": "3.1.26.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046332 SMAD binding;GO:0001530 lipopolysaccharide binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0031054 pre-miRNA processing;GO:0006364 rRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 14.4,
        "record_id": "Q9NRR4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P56270-1",
        "uniprot_id": "MAZ_HUMAN",
        "mass": 48608.0,
        "length": 477,
        "protein_name": "Myc-associated zinc finger protein",
        "gene_name": "MAZ",
        "organism": "Human",
        "refseq_name": "myc-associated zinc finger protein isoform 2",
        "refseq_ac": "NP_001036004",
        "gene_names_uniprotkb": "MAZ; ZNF801",
        "gene_names_refseq": "MAZ; PUR1; Pur-1; SAF-1; SAF-2; SAF-3; ZF87; ZNF801; Zif87",
        "protein_names_uniprotkb": "Myc-associated zinc finger protein; MAZI; Pur-1; Purine-binding transcription factor; SAF-1; Serum amyloid A-activating factor-1; Transcription factor Zif87; ZF87; Zinc finger protein 801",
        "protein_names_refseq": "MAZI; myc-associated zinc finger protein isoform 2; purine-binding transcription factor; serum amyloid A activating factor 1; serum amyloid A activating factor 2; transcription factor Zif87; zinc finger protein 801; zinc-finger protein, 87 kilodaltons",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4150)",
        "pathway_count": 1,
        "publication_count": 72,
        "publication_id_list": "10448092;10727212;11237011;11809795;12270922;12697757;1502157;1567856;19583771;20068231;23186163;23481700;24715725;25576301;25645385;25810538;26154972;26902421;26992070;27600516;27920218;28228285;28514659;28832583;28855257;28904123;29242379;29393594;29493099;29632046;30429286;30524438;31154438;31217245;31530632;31844290;31848261;32157095;32161166;32357974;32387766;32897882;32938616;32983136;33123756;33298915;33392160;33592498;33912179;33936100;33968037;33981976;34087483;34171305;34351390;34405274;34509645;34561969;35051231;35580925;35705054;36010968;37664917;38189915;38316778;38665916;39197582;39302247;39531497;8626793;8831693;9685418",
        "class_list": "",
        "function": "Binds DNA and functions as a transcriptional activator (PubMed:12270922). Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former (PubMed:1502157). Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors (PubMed:1502157)., [UniProtKB, PubMed, PubMed]; Binds DNA and functions as a transcriptional activator (PubMed:12270922). Inhibits MAZ isoform 1-mediated transcription (PubMed:12270922)., [UniProtKB, PubMed]; Binds DNA and functions as a transcriptional activator., [UniProtKB, PubMed]; G-quadruplexes promote the motility in MAZ phase-separated condensates to activate CCND1 expression and contribute to hepatocarcinogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Genome-wide functional integration identified MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma., [RefSeq, PubMed]; Identification of the transcription factor MAZ as a regulator of erythropoiesis. Erratum:[Blood Adv. 2022 Mar 22;6(6):1854. doi: 10.1182/bloodadvances.2021006651. PMID: 35298619], [RefSeq, PubMed]; MAZ promotes thyroid cancer progression by driving transcriptional reprogram and enhancing ERK1/2 activation., [RefSeq, PubMed]; Myc-Associated Zinc Finger Protein Promotes Metastasis of Papillary Thyroid Cancer., [RefSeq, PubMed]; Transcriptional regulator, potentially with dual roles in transcription initiation and termination., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
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        "total_o_glycosites": 2,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8QJL9;C6G496;G5E927;H3BQD6;Q15703;Q8NFN7;Q99443",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 7.6,
        "record_id": "P56270-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75461-1",
        "uniprot_id": "E2F6_HUMAN",
        "mass": 31844.0,
        "length": 281,
        "protein_name": "Transcription factor E2F6",
        "gene_name": "E2F6",
        "organism": "Human",
        "refseq_name": "transcription factor E2F6 isoform 2",
        "refseq_ac": "NP_001265204",
        "gene_names_uniprotkb": "E2F6",
        "gene_names_refseq": "E2F-6; E2F6",
        "protein_names_uniprotkb": "Transcription factor E2F6; E2F-6",
        "protein_names_refseq": "transcription factor E2F6 isoform 2; transcription factor E2F6",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283)",
        "pathway": " (hsa:1876);  (R-HSA-69205);  (R-HSA-8953750)",
        "pathway_count": 3,
        "publication_count": 70,
        "publication_id_list": "10228158;10454584;10597240;10692433;11171983;11237011;11959842;11988738;12004135;12782299;12909625;14990995;15014447;15081404;15510213;15536069;15960975;17001316;17600109;18562691;21596310;23954429;24366607;24627085;24715725;25418920;25880248;26154972;26811146;26929215;28228285;28832583;28834231;29242379;29393594;29485866;29557506;29632046;30315122;31844290;32157095;32161166;32265295;32387766;32488085;32897882;32938616;32983136;33298915;33912179;34171305;34509645;35494241;36241641;36525235;38153509;38166853;7623816;7929342;8114698;8288595;8618861;8943353;9020173;9501179;9520412;9662327;9689056;9704927;9778043",
        "class_list": "",
        "function": "A hsa_circ_001726 axis regulated by E2F6 contributes to metastasis of hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Contains nine exons distributed along 20.4kbp of genomic DNA on chromosome 2 leading to the transcription of six alternatively spliced E2F6 mRNAs that encode four different E2F6 proteins, [RefSeq, PubMed]; Data suggest that E2F- and Myc-responsive genes are coregulated by E2F6 complex in quiescent cells, [RefSeq, PubMed]; Inhibitor of E2F-dependent transcription (PubMed:9501179, PubMed:9689056, PubMed:9704927). Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:9501179). Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9501179). E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9501179, PubMed:9704927). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (PubMed:9501179, PubMed:9689056). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (PubMed:9501179)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; LncRNA ENST00000585827 Contributes to the Progression of Endometrial Carcinoma via Regulating miR-424/E2F6/E2F7 Axis., [RefSeq, PubMed]; Results suggest that E2F6 represses transcription of the brca1, ctip, art27, hp1alpha, and the rbap48 genes and depletion of E2F6 resulted in the recruitment of E2F1 to the target promoters, [RefSeq, PubMed]; The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding., [RefSeq, PubMed]; This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2Z8;G5E936;O60544;Q53QY9;Q6Q9Z6;Q7Z2H6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0071339 MLL1 complex;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0031507 heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "O75461-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N136-1",
        "uniprot_id": "DAW1_HUMAN",
        "mass": 45777.0,
        "length": 415,
        "protein_name": "Dynein assembly factor with WD repeat domains 1",
        "gene_name": "DAW1",
        "organism": "Human",
        "refseq_name": "dynein assembly factor with WD repeat domains 1 isoform 2",
        "refseq_ac": "NP_001316933",
        "gene_names_uniprotkb": "DAW1; ODA16; WDR69",
        "gene_names_refseq": "CILD52; DAW1; DNAAF18; ODA16; WDR69",
        "protein_names_uniprotkb": "Dynein assembly factor with WD repeat domains 1; Outer row dynein assembly protein 16 homolog; WD repeat-containing protein 69",
        "protein_names_refseq": "WD repeat domain 69; WD repeat-containing protein 69; dynein assembly factor with WD repeat domains 1 isoform 2; dynein assembly factor with WD repeat domains 1; dynein assembly factor with WDR repeat domains 1; dynein axonemal assembly factor 18; outer row dynein assembly 16 homolog; outer row dynein assembly protein 16 homolog; testis tissue sperm-binding protein Li 93mP",
        "tax_id": 9606,
        "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia (Disease Ontology:DOID:9562); ciliary dyskinesia, primary, 52 (MONDO:MONDO:0957922)",
        "pathway": " (hsa:164781)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;16093345;16959974;18852297;28991257;30779550;32239748;33592498;34211107;35051231;36074124",
        "class_list": "",
        "function": "Biallelic DAW1 variants cause a motile ciliopathy characterized by laterality defects and subtle ciliary beating abnormalities., [RefSeq, PubMed]; Purification and crystal structure of human ODA16: Implications for ciliary import of outer dynein arms by the intraflagellar transport machinery., [RefSeq, PubMed]; Required for axonemal dynein assembly and ciliary motility in ciliated organs, including Kupffer's vesicle, during embryogenesis (PubMed:36074124). Facilitates the onset of robust cilia motility during development (PubMed:36074124)., [UniProtKB, PubMed]; This paper describes a Chlamydmonas reinhardtii protein with 70% similarity to human WD repeat domain 69 protein. The protein is expressed in flagella and required for assembly of the flagellar outer row dynein ATPase, though it is not a dynein subunit., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ZRY1;Q8N776",
        "ec_number_list": "",
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005929 cilium;GO:0019005 SCF ubiquitin ligase complex;GO:0036064 ciliary basal body",
        "go_biological_process": "GO:0007507 heart development;GO:0007368 determination of left/right symmetry;GO:0000209 protein polyubiquitination;GO:0042073 intraciliary transport;GO:0036158 outer dynein arm assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8N136-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15329-1",
        "uniprot_id": "E2F5_HUMAN",
        "mass": 37610.0,
        "length": 346,
        "protein_name": "Transcription factor E2F5",
        "gene_name": "E2F5",
        "organism": "Human",
        "refseq_name": "transcription factor E2F5 isoform 2",
        "refseq_ac": "NP_001077057",
        "gene_names_uniprotkb": "E2F5",
        "gene_names_refseq": "E2F-5; E2F5",
        "protein_names_uniprotkb": "Transcription factor E2F5; E2F-5",
        "protein_names_refseq": "E2F transcription factor 5, p130-binding; transcription factor E2F5 isoform 2; transcription factor E2F5",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); hydrocephalus (Disease Ontology:DOID:10908)",
        "pathway": " (hsa:1875);  (R-HSA-1362277);  (R-HSA-1362300);  (R-HSA-1538133);  (R-HSA-2173796);  (R-HSA-69202);  (R-HSA-69205);  (R-HSA-69231);  (R-HSA-69656)",
        "pathway_count": 9,
        "publication_count": 170,
        "publication_id_list": "10022869;10199400;10207050;10228158;10323868;10375532;10385618;10454565;10454584;10499802;10597240;10692433;10783242;10831586;11007770;11013220;11032757;11073976;11157749;11231573;11231585;11237011;11274402;11416152;11424093;11427533;11585773;11719808;11884610;11907280;11959842;11988738;12150994;12435635;12444543;12446674;12730199;12782299;12917425;1312467;1396589;1423597;14517297;14597415;14657019;14990995;15014447;15100235;15150273;15510213;15579463;16195327;16278212;16319104;16360038;16582612;16782892;17092340;17254966;17254967;17438144;17531812;17908796;1828392;1828393;1828394;18414028;18568018;18710949;18827403;19075005;19458076;19487459;19914168;20107323;20595680;20663872;20843055;20952511;21423214;21498570;21715330;22275377;22645359;23007395;23481700;23622515;23737759;24366607;24515438;24876129;25733683;26992070;27846572;27920218;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29632046;30315122;30410026;30524438;30711375;31217245;31543423;31844290;31848261;31936902;32265295;32350084;32387766;32502341;32897882;32938616;32983136;33691108;33912179;33968037;35051231;35251023;35985439;36010968;36241641;37567906;37832805;38271139;7623816;7629134;7743995;7760804;7797074;7799941;7892279;7929342;7954814;8050359;8114698;8114739;8139570;8246996;8288595;8336704;8497257;8589754;8618861;8700224;8943353;9020173;9042862;9106657;9144196;9190208;9199292;9325318;9447971;9448290;9464260;9482921;9508775;9520412;9632134;9662327;9724731;9778043;9891042",
        "class_list": "",
        "function": "Expression of CD44 is regulated by ELF3 in 5-FU treated colorectal cancer cells., [RefSeq, PubMed]; Knockdown of RNA-binding protein IMP3 suppresses oral squamous cell carcinoma proliferation by destabilizing E2F5 transcript., [RefSeq, PubMed]; METTL3 promotes the growth and metastasis of pancreatic cancer by regulating the m6A modification and stability of E2F5., [RefSeq, PubMed]; The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis., [UniProtKB, UniProtKB]; Transcriptional induction of NF-kappaB-inducing kinase by E2F4/5 facilitates collective invasion of GBM cells. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
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        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PBN9;Q16601;Q92756",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0030030 cell projection organization",
        "synthesized_glycan_count": 0,
        "hit_score": 17.1,
        "record_id": "Q15329-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T6F0-1",
        "uniprot_id": "DCA12_HUMAN",
        "mass": 50517.0,
        "length": 453,
        "protein_name": "DDB1- and CUL4-associated factor 12",
        "gene_name": "DCAF12",
        "organism": "Human",
        "refseq_name": "DDB1- and CUL4-associated factor 12",
        "refseq_ac": "NP_056212",
        "gene_names_uniprotkb": "DCAF12; KIAA1892; TCC52; WDR40A",
        "gene_names_refseq": "CT102; DCAF12; KIAA1892; TCC52; WDR40A",
        "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 12; Centrosome-related protein TCC52; Testis cancer centrosome-related protein; WD repeat-containing protein 40A",
        "protein_names_refseq": "DDB1- and CUL4-associated factor 12; WD repeat domain 40A; WD repeat-containing protein 40A; cancer/testis antigen 102; centrosome-related protein TCC52; testis cancer centrosome-related protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25853)",
        "pathway_count": 1,
        "publication_count": 48,
        "publication_id_list": "11237011;16949367;16964240;17081983;18096478;18491316;18957058;19966799;23186163;24715725;25576301;26811146;26992070;27846572;28904123;29437277;29557506;29779948;30315122;30410026;31154438;31267705;31844290;31848261;32157095;32161166;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33691108;33912179;33968037;33981976;34065512;34171305;34211107;34932366;35051231;35580925;36010968;36241641;36284347;38740147",
        "class_list": "",
        "function": "CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation. Publication Status: Online-Only, [RefSeq, PubMed]; Of the classifier's 11 informative genes, expression of MIR and WDR40 showed statistically significant increases for both Grade 1B and Grade >or=3A rejection., [RefSeq, PubMed]; Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:16949367, PubMed:16964240, PubMed:29779948). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948). The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:31267705). Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy (PubMed:31267705). Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins such as MOV10, leading to their ubiquitination and degradation. Controls the protein level of MOV10 during spermatogenesis and in T cells, especially after their activation (PubMed:34065512)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; TCC52, as a novel CT antigen, would be a promising candidate for cancer immunotherapy., [RefSeq, PubMed]; This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KA70;D3DRL6;Q5T6E9;Q5T6F1;Q6P3V0;Q7L4F8;Q96PZ5;Q9NXA9;Q9UFJ1",
        "ec_number_list": "",
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0080008 Cul4-RING E3 ubiquitin ligase complex",
        "go_biological_process": "GO:0010506 regulation of autophagy;GO:0042127 regulation of cell population proliferation;GO:0060964 regulation of miRNA-mediated gene silencing;GO:0042110 T cell activation;GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q5T6F0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P52824-1",
        "uniprot_id": "DGKQ_HUMAN",
        "mass": 101155.0,
        "length": 942,
        "protein_name": "Diacylglycerol kinase theta",
        "gene_name": "DGKQ",
        "organism": "Human",
        "refseq_name": "diacylglycerol kinase theta",
        "refseq_ac": "NP_001338",
        "gene_names_uniprotkb": "DGKQ; DAGK4",
        "gene_names_refseq": "DAGK4; DAGK7; DAGK; DGKQ",
        "protein_names_uniprotkb": "Diacylglycerol kinase theta; 2.7.1.107; 2.7.1.93; DAG kinase theta; DGK-theta; DGKtheta; Diglyceride kinase theta",
        "protein_names_refseq": "DAG kinase theta; DGK-theta; DGKtheta; diacylglycerol kinase theta; diacylglycerol kinase, theta 110kDa; diglyceride kinase theta; testis tissue sperm-binding protein Li 38a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1609);  (R-HSA-114508)",
        "pathway_count": 2,
        "publication_count": 48,
        "publication_id_list": "10066731;11080611;11237011;11309392;11413485;11805119;12799190;15164764;15632189;17664281;19033211;2175712;22627129;23949095;24369117;26748701;26992070;27600516;27893789;28467828;28834231;28904123;29242379;29557506;29789417;30379171;30833945;31154438;31836314;31844290;31998317;32157095;32161166;32938616;33559030;33592498;33912179;34171305;34932366;35051231;35580925;36010968;36284347;37938771;7607687;9099683;9601053;9930701",
        "class_list": "",
        "function": "Association study of MCCC1/LAMP3 and DGKQ variants with Parkinson's disease in patients of Malay ancestry., [RefSeq, PubMed]; Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription. Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor. Through its diacylglycerol activity also regulates synaptic vesicle endocytosis., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Roles of DGKs in neurons: Postsynaptic functions? Review article Erratum:[Adv Biol Regul. 2021 Dec;82:100846. doi: 10.1016/j.jbior.2021.100846. PMID: 34862141], [RefSeq, PubMed]; The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]., [RefSeq]; These data demonstrate that DGKtheta; plays an important role in steroid hormone production in human adrenocortical cells, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6P3W4",
        "ec_number_list": "2.7.1.107;2.7.1.93;2.7.1.94;2.7.1.138",
        "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019900 kinase binding;GO:0030971 receptor tyrosine kinase binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005768 endosome",
        "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006654 phosphatidic acid biosynthetic process;GO:0007186 G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "P52824-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P41214-1",
        "uniprot_id": "EIF2D_HUMAN",
        "mass": 64706.0,
        "length": 584,
        "protein_name": "Eukaryotic translation initiation factor 2D",
        "gene_name": "EIF2D",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 2D isoform 2",
        "refseq_ac": "NP_001188407",
        "gene_names_uniprotkb": "EIF2D; HCA56; LGTN",
        "gene_names_refseq": "EIF2D; HCA56; LGTN",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2D; Hepatocellular carcinoma-associated antigen 56; Ligatin; eIF2d",
        "protein_names_refseq": "eukaryotic translation initiation factor 2D isoform 2; hepatocellular carcinoma-associated antigen 56; ligatin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1939)",
        "pathway_count": 1,
        "publication_count": 52,
        "publication_id_list": "11237011;12097419;15302935;18669648;19608861;20068231;20566627;20713520;23186163;24715725;2482295;25576301;26154972;26992070;27846572;27920218;28228285;28240315;28832583;28904123;29242379;29493099;29508533;29632711;29786170;30315122;30419262;30429286;30958601;31078689;31844290;32157095;32488085;32502341;32938616;33141586;33298915;33392160;33537174;33912179;33936100;33968037;33981976;34185709;34211107;34357683;35051231;35580925;36010968;36689548;37938771;38433101",
        "class_list": "",
        "function": "A novel uORF-based regulatory mechanism that is employed under conditions of hyperosmotic stress by at least two human mRNAs, coding for translation reinitiation/recycling factor eIF2D and E3 ubiquitin ligase MDM2. This novel mode of translational control selectively downregulates their expression and requires as few as one uORF., [RefSeq, PubMed]; Data suggest that neither eIF2A nor eIF2D are involved in the translation of this Sindbis virus subgenomic mRNA (sgmRNA) bearing non-AUG codons Publication Status: Online-Only, [RefSeq, PubMed]; The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]., [RefSeq]; This is the first report which confirms the presence of ligatin and fibulin-7 in human aqueous humor, quantified their differential expression, and indicated the possibility of their involvement in the maintenance of the trabecular meshwork structure in glaucoma progression., [RefSeq, PubMed]; To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1.DENR to deliver initiator tRNA to ribosomes. Review article, [RefSeq, PubMed]; Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits., [UniProtKB, PubMed, PubMed]; We observed a positive correlation trend between EIF2D mRNA levels and years of schizophrenia (SZ) disease (p=0.0794; r=0.35). We found a trend of an increase in the expression levels of EIF2D (p=0.0634) in patients suffering from the disease more than 10years compared with the SZ patients from the other subgroup ., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5SY40;Q8IXV3;Q96DG3;Q96TG7;Q9NR27;Q9NSN0;Q9NV18;Q9NZ21",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity;GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0032790 ribosome disassembly;GO:0075522 IRES-dependent viral translational initiation;GO:0006886 intracellular protein transport;GO:0001731 formation of translation preinitiation complex",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "P41214-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NUU7-1",
        "uniprot_id": "DD19A_HUMAN",
        "mass": 53975.0,
        "length": 478,
        "protein_name": "ATP-dependent RNA helicase DDX19A",
        "gene_name": "DDX19A",
        "organism": "Human",
        "refseq_name": "ATP-dependent RNA helicase DDX19A isoform 2",
        "refseq_ac": "NP_001307451",
        "gene_names_uniprotkb": "DDX19A; DDX19L",
        "gene_names_refseq": "DDX19-DDX19L; DDX19A; DDX19L",
        "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX19A; 3.6.4.13; DDX19-like protein; DEAD box protein 19A",
        "protein_names_refseq": "ATP-dependent RNA helicase DDX19A isoform 2; ATP-dependent RNA helicase DDX19A; DDX19-like protein; DEAD (Asp-Glu-Ala-As) box polypeptide 19A; DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A; DEAD box protein 19A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55308)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "11237011;22223895;25114211;25218447;25880248;26154972;26992070;27846572;27920218;28063628;28228285;28510447;28514659;28649982;28832583;28834231;28860189;28904123;29242379;29393594;29508533;29632046;29786170;30192525;30315122;30397120;30833945;31222486;31844290;31848261;31998317;32265295;32350084;32357974;32387766;32488085;33214551;33298915;33592498;33717175;33912179;33981976;34019948;34171305;34229054;34405274;34612147;35138101;35251023;36284347;38665916",
        "class_list": "",
        "function": "ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins., [UniProtKB, UniProtKB]; Silencing of let-7b-5p inhibits ovarian cancer cell proliferation and stemness characteristics by Asp-Glu-Ala-Asp-box helicase 19A., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RPL0;B4DRZ7;Q53FM0",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016020 membrane;GO:0010494 cytoplasmic stress granule;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0010043 response to zinc ion;GO:0043065 positive regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q9NUU7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P56537-1",
        "uniprot_id": "IF6_HUMAN",
        "mass": 26599.0,
        "length": 245,
        "protein_name": "Eukaryotic translation initiation factor 6",
        "gene_name": "EIF6",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 6 isoform a",
        "refseq_ac": "NP_001254739",
        "gene_names_uniprotkb": "EIF6; EIF3A; ITGB4BP; SW-cl.27",
        "gene_names_refseq": "CAB; EIF3A; EIF6; ITGB4BP; b(2)gcn; eIF-6; p27(BBP); p27BBP",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 6; B(2)GCN homolog; B4 integrin interactor; CAB; eIF-6; p27(BBP)",
        "protein_names_refseq": "B4 integrin interactor; eukaryotic translation initiation factor 3A; eukaryotic translation initiation factor 6 isoform a; p27 beta-4 integrin-binding protein",
        "tax_id": 9606,
        "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:3692)",
        "pathway_count": 1,
        "publication_count": 88,
        "publication_id_list": "10085284;11237011;11290417;12917340;14654845;15592455;17507929;18452278;18669648;18991276;19007248;20068231;21084295;21536732;21665150;23301498;24714562;25548167;25576301;25645385;26992070;27600516;27862975;27920218;28228285;28510447;28832583;28834231;28904123;29242379;29557506;29789417;30315122;30429286;30626607;31154438;31217245;31373491;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32669547;32897882;32938616;33123756;33214551;33592498;33691108;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34229054;34561969;34725712;34932366;35008409;35024764;35051231;35154160;35251023;35318648;35580925;35887068;36010968;36241641;36284347;36651285;37217939;37340703;37776372;37938771;38665916;38987443;39302247;40307207;40596516;40914422;9374518;9405604;9653160",
        "class_list": "",
        "function": "Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm (PubMed:10085284, PubMed:14654845, PubMed:21536732, PubMed:32669547). Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity)., [UniProtKB, PubMed, PubMed, HAMAP, PubMed, PubMed, PubMed]; Circular RNA eukaryotic translation initiation factor 6 facilitates TPC-1 cell proliferation and invasion through the microRNA-138-5p/lipase H axis. Publication Status: Online-Only, [RefSeq, PubMed]; Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit., [RefSeq, PubMed]; EIF6 Promotes Gastric Cancer Proliferation and Invasion by Regulating Cell Cycle., [RefSeq, PubMed]; Eukaryotic initiation factor 6 regulates mechanical responses in endothelial cells., [RefSeq, PubMed]; Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]., [RefSeq]; Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZBG9;Q6IBN8;Q96TD5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity;GO:0043023 ribosomal large subunit binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006110 regulation of glycolytic process;GO:0042304 regulation of fatty acid biosynthetic process;GO:0000054 ribosomal subunit export from nucleus;GO:0032868 response to insulin;GO:0045652 regulation of megakaryocyte differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "P56537-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q0PNE2-1",
        "uniprot_id": "ELP6_HUMAN",
        "mass": 29793.0,
        "length": 266,
        "protein_name": "Elongator complex protein 6",
        "gene_name": "ELP6",
        "organism": "Human",
        "refseq_name": "elongator complex protein 6 isoform 1",
        "refseq_ac": "NP_001026873",
        "gene_names_uniprotkb": "ELP6; ATP1; C3orf75; TMEM103",
        "gene_names_refseq": "C3orf75; ELP6; TMEM103",
        "protein_names_uniprotkb": "Elongator complex protein 6; Angiotonin-transactivated protein 1; Protein TMEM103",
        "protein_names_refseq": "UPF0405 protein C3orf75; angiotonin-transactivated protein 1; elongator complex protein 6 homolog; elongator complex protein 6 isoform 1; transmembrane protein 103",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54859);  (R-HSA-3214847)",
        "pathway_count": 2,
        "publication_count": 44,
        "publication_id_list": "10786633;10821277;11237011;15313887;16387653;18381289;18623064;19187765;20018852;22645656;22854966;24284306;25418920;25576301;26811146;26992070;27600516;28514659;28649982;28832583;28904123;29242379;29332244;29557506;29786170;31844290;32157095;32350084;32387766;32502341;32897882;32938616;32983136;33592498;33691108;33936100;33968037;35051231;35561310;36010968;36241641;9427644;9558366;9880483",
        "class_list": "",
        "function": "Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:22854966, PubMed:29332244). Involved in cell migration (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Data identify DERP6/ELP5 and C3ORF75/ELP6 as key players for migration, invasion and tumorigenicity of melanoma cells, as integral subunits of Elongator., [RefSeq, PubMed]; ELP6 is expressed intracellularly in developing and mature granulocytes and monocytes but not in lymphocytes and erythrocytes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BW57;Q9NXJ3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0033588 elongator holoenzyme complex",
        "go_biological_process": "GO:0006417 regulation of translation;GO:0030335 positive regulation of cell migration;GO:0002098 tRNA wobble uridine modification",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q0PNE2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NDI1-1",
        "uniprot_id": "EHBP1_HUMAN",
        "mass": 140017.0,
        "length": 1231,
        "protein_name": "EH domain-binding protein 1",
        "gene_name": "EHBP1",
        "organism": "Human",
        "refseq_name": "EH domain-binding protein 1 isoform 2",
        "refseq_ac": "NP_001136086",
        "gene_names_uniprotkb": "EHBP1; KIAA0903; NACSIN",
        "gene_names_refseq": "EHBP1; HPC12; NACSIN",
        "protein_names_uniprotkb": "EH domain-binding protein 1",
        "protein_names_refseq": "EH domain-binding protein 1 isoform 2; NPF calponin-like protein; testis tissue sperm-binding protein Li 50e",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283)",
        "pathway": " (hsa:23301)",
        "pathway_count": 1,
        "publication_count": 63,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;14676205;15144186;16959974;18220336;18264098;18452278;18669648;19318432;19413330;19423541;19549807;19651622;19690332;20068231;20166139;21406692;22544926;23186163;23481700;24275569;24715725;25576301;26154972;26992070;27552051;27600516;27862975;28228285;28832583;29242379;29508533;29557506;29786170;29789417;30379171;30429286;30524438;31154438;31844290;31848261;31937595;32157095;32295536;32387766;32502341;32826901;32897882;32938616;33298915;33592498;33717175;33968037;33981976;34171305;34509645;35051231;35494241;35580925;36010968;36241641;36284347",
        "class_list": "",
        "function": "EHBP1 is an EH domain binding protein that, along with EHD2, has a role in coupling endocytosis to the actin cytoskeleton, [RefSeq, PubMed]; May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed, PubMed]; The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members. Publication Status: Online-Only, [RefSeq, PubMed]; The purpose of this study was to evaluate the association of rs16901979, rs4242382 and rs1447295 on 8q24 locus, rs2735839 (KLK3 gene) and rs721048 (EHBP1 gene) with prostate adenocarcinoma through multi-stage approach to identify the polymorphisms associated with prostate cancer and use them as screening factors Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "predicted_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 24,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O94977;Q53TG7;Q53TV6;Q580X2;Q6NX72;Q6PIT3;Q6QNV2;Q9NWI9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0030036 actin cytoskeleton organization;GO:0032456 endocytic recycling",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q8NDI1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P62266-1",
        "uniprot_id": "RS23_HUMAN",
        "mass": 15808.0,
        "length": 143,
        "protein_name": "Small ribosomal subunit protein uS12",
        "gene_name": "RPS23",
        "organism": "Human",
        "refseq_name": "small ribosomal subunit protein uS12",
        "refseq_ac": "NP_001016",
        "gene_names_uniprotkb": "RPS23",
        "gene_names_refseq": "BTDD; MABAS; MCINS; PAMAS; RPS23; S23; uS12",
        "protein_names_uniprotkb": "Small ribosomal subunit protein uS12; 40S ribosomal protein S23",
        "protein_names_refseq": "40S ribosomal protein S23; homolog of yeast ribosomal protein S28; small ribosomal subunit protein uS12",
        "tax_id": 9606,
        "disease": "brachycephaly, trichomegaly, and developmental delay (Disease Ontology:DOID:0070415)",
        "pathway": " (hsa:6228);  (R-HSA-156827);  (R-HSA-156902);  (R-HSA-1799339);  (R-HSA-192823);  (R-HSA-2408557);  (R-HSA-6791226);  (R-HSA-72649);  (R-HSA-72689);  (R-HSA-72695);  (R-HSA-72702);  (R-HSA-72706);  (R-HSA-72764);  (R-HSA-9010553);  (R-HSA-9629569);  (R-HSA-9633012);  (R-HSA-9735869);  (R-HSA-9754678);  (R-HSA-975956);  (R-HSA-975957);  (R-HSA-9954714);  (R-HSA-9954716)",
        "pathway_count": 22,
        "publication_count": 320,
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        "class_list": "",
        "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:28257692). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399, PubMed:25901680, PubMed:25957688). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399, PubMed:25901680, PubMed:25957688). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25901680, PubMed:25957688). Plays an important role in translational accuracy (PubMed:28257692). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Identification of Hub Genes in Gastric Cancer with High Heterogeneity Based on Weighted Gene Co-Expression Network., [RefSeq, PubMed]; Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12P family of ribosomal proteins. It is located in the cytoplasm. The protein shares significant amino acid similarity with S. cerevisiae ribosomal protein S28. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; The study results reveal a role for RPS23RG1 in maintaining synaptic integrity and function and provide a new mechanism for synaptic dysfunction in Alzheimer's disease (AD) pathogenesis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "reported_n_glycosites": 0,
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        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P39028;Q6IB08",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0006412 translation;GO:0034063 stress granule assembly;GO:1990145 maintenance of translational fidelity;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 32.5,
        "record_id": "P62266-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99613-1",
        "uniprot_id": "EIF3C_HUMAN",
        "mass": 105344.0,
        "length": 913,
        "protein_name": "Eukaryotic translation initiation factor 3 subunit C",
        "gene_name": "EIF3C",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 3 subunit C isoform a",
        "refseq_ac": "NP_001032897",
        "gene_names_uniprotkb": "EIF3C; EIF3S8",
        "gene_names_refseq": "EIF3C; EIF3S8; eIF3-p110",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit C; Eukaryotic translation initiation factor 3 subunit 8; eIF3 p110; eIF3c",
        "protein_names_refseq": "cell migration-inducing protein 17; eukaryotic translation initiation factor 3 subunit C isoform a",
        "tax_id": 9606,
        "disease": "brucellosis (Disease Ontology:DOID:11077); depressive disorder (Disease Ontology:DOID:1596)",
        "pathway": " (hsa:8663);  (R-HSA-156827);  (R-HSA-72649);  (R-HSA-72689);  (R-HSA-72695);  (R-HSA-72702);  (R-HSA-72706)",
        "pathway_count": 7,
        "publication_count": 115,
        "publication_id_list": "10203015;10364207;10659855;1095581;11018020;1104615;11237011;12493757;12588972;14519125;14567916;15302935;15703437;16023166;16083285;16286006;16322461;16766523;16964243;16973618;17081983;17287340;17322306;17322308;17468741;17581632;17697703;18212344;18452278;18510355;1856230;18578522;18599441;18669648;18707149;18767875;18991276;19007248;19413330;19541769;19651622;19664994;19664995;20058876;20068231;20112406;21872626;22424782;22645359;23145062;23301498;24366607;24714562;24715725;25418920;25469497;25502872;25505266;25576301;25810538;25849773;26024233;26154972;26768311;26992070;27397612;27462815;28904123;29437277;29557506;30315122;30429286;30484775;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31937595;31998317;32161166;32265295;32502341;33141586;33214551;33392160;33414445;33465208;33537174;33981976;34019948;34078123;34185709;34260931;35138101;35650605;36215666;36284347;37996918;40914422;429297;592398;592399;641056;6853548;6901506;7000367;8943342;8995409;9045610;9732867;9857202",
        "class_list": "",
        "function": "CircPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA. Publication Status: Online-Only, [RefSeq, PubMed]; Complement factor H attenuates TNF-alpha-induced inflammation by upregulating EIF3C in rheumatoid arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)., [UniProtKB, PubMed, HAMAP, PubMed, PubMed]; Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism., [RefSeq, PubMed]; ZNF280A promotes lung adenocarcinoma development by regulating the expression of EIF3C. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7Z0;B2RXG3;B4E1D5;H3BRV0;O00215;Q9BW98",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex",
        "go_biological_process": "GO:0006413 translational initiation;GO:0045727 positive regulation of translation;GO:0001732 formation of cytoplasmic translation initiation complex",
        "synthesized_glycan_count": 0,
        "hit_score": 11.8,
        "record_id": "Q99613-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60231-1",
        "uniprot_id": "DHX16_HUMAN",
        "mass": 119264.0,
        "length": 1041,
        "protein_name": "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16",
        "gene_name": "DHX16",
        "organism": "Human",
        "refseq_name": "pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 2",
        "refseq_ac": "NP_001157711",
        "gene_names_uniprotkb": "DHX16; DBP2; DDX16; KIAA0577; PRP2",
        "gene_names_refseq": "DBP2; DDX16; DHX16; NMOAS; PRO2014; PRP8; PRPF2; Prp2",
        "protein_names_uniprotkb": "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; 3.6.4.13; ATP-dependent RNA helicase #3; DEAH-box protein 16",
        "protein_names_refseq": "ATP-dependent RNA helicase #3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16; DEAD/H box 16; DEAH (Asp-Glu-Ala-His) box polypeptide 16; DEAH-box protein 16; pre-mRNA processing factor 2; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform 2; putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16",
        "tax_id": 9606,
        "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); epilepsy (Disease Ontology:DOID:1826); neuromuscular disease and ocular or auditory anomalies with or without seizures (MONDO:MONDO:0032890)",
        "pathway": " (hsa:8449);  (R-HSA-72163);  (R-HSA-9918481)",
        "pathway_count": 3,
        "publication_count": 179,
        "publication_id_list": "10882114;11014198;11101529;11233976;11237011;11747608;11991638;12176931;12411573;12414731;12477934;14519844;14625303;14713954;14762106;15084397;16314458;16809785;16964243;17081983;17095540;17322306;17332742;17606899;18318008;18322460;18446792;18452278;18491316;18593880;18669648;18767875;19103666;19165350;19413330;19415658;19536130;19651622;19664994;19690332;20068231;20166139;20423332;20841358;20980672;21406692;21536652;2176635;21911577;22110043;22365833;22959432;22961380;23186163;23222130;23236153;23301498;23345524;23481700;24196718;24304693;24448447;24714562;24715725;24737827;24914973;25296192;25555158;2558966;25645385;25880248;25892735;26092250;26375851;26385511;26420826;26969736;26992070;27108190;27377154;27459055;27600516;27683217;27846572;27862975;27920218;28062851;28076346;28228285;28502770;28510447;28781166;28832583;28904123;29242379;29301961;29360106;29361316;29393594;29493099;29508533;29557506;29632046;29632711;2963332;29769354;29902443;30315122;30315277;30429286;30599162;30705154;30728453;30765414;30975767;31092671;31256877;31409651;31844290;31848261;32157095;32179686;32329775;32357974;32387766;32488085;32494006;32502341;32897882;32938616;32983136;33123756;33141586;33177556;33243851;33298915;33446560;33509932;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34211107;34301950;34509645;34561969;34725712;34822310;34932366;35051231;35215846;35263596;35385551;35580925;36010968;36241641;36284347;36581221;3757028;37574199;37938771;39302247;8566756;8608946;9016565;9242493;9512519;9524131;9539711;9547260;9671485;9701291;9731529",
        "class_list": "",
        "function": "DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]., [RefSeq]; Infantile onset encephalomyopathy, retinopathy, optic atrophy, and mitochondrial DNA depletion associated with a novel pathogenic DHX16 variant., [RefSeq, PubMed]; Required for pre-mRNA splicing as a component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA (PubMed:35263596). Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses (PubMed:35263596)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60322;Q5JP45;Q969X7;Q96QC1",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;2.3.2.27;5.2.1.8;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.1.13.-;2.7.7.48;2.7.7.6;3.6.4.12;3.4.21.53;5.6.2.5;2.7.7.19;3.1.-.-;3.6.5.-;7.6.2.1;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;2.7.1.78;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;3.1.27.-;2.7.4.3",
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043130 ubiquitin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0071005 U2-type precatalytic spliceosome",
        "go_biological_process": "GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0140374 antiviral innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 18.2,
        "record_id": "O60231-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P14138-1",
        "uniprot_id": "EDN3_HUMAN",
        "mass": 25454.0,
        "length": 238,
        "protein_name": "Endothelin-3",
        "gene_name": "EDN3",
        "organism": "Human",
        "refseq_name": "endothelin-3 isoform 4 preproprotein",
        "refseq_ac": "NP_001289384",
        "gene_names_uniprotkb": "EDN3",
        "gene_names_refseq": "EDN3; ET-3; ET3; HSCR4; PPET3; WS4B",
        "protein_names_uniprotkb": "Endothelin-3; ET-3; PPET3; Preproendothelin-3",
        "protein_names_refseq": "endothelin-3 isoform 4 preproprotein; preproendothelin-3",
        "tax_id": 9606,
        "disease": "Waardenburg syndrome type 4B (Disease Ontology:DOID:0110954); Hirschsprung's disease (Disease Ontology:DOID:10487); Waardenburg syndrome (Disease Ontology:DOID:9258); Hirschsprung disease, susceptibility to, 4 (MONDO:MONDO:0013384)",
        "pathway": " (hsa:1908);  (R-HSA-375276);  (R-HSA-416476);  (R-HSA-9856649)",
        "pathway_count": 4,
        "publication_count": 183,
        "publication_id_list": "10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567402;10567430;10604470;10611221;10655586;10673502;10727532;10854085;10861009;10899166;11015615;11027551;11237011;11303518;11322507;11385580;11457843;11562423;11683476;11742120;11753430;11773063;11840323;11891324;11912130;11930005;12120503;12189494;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;14975237;15118077;15139756;15226305;15507434;15539556;1567413;15947423;15951850;16014379;16034366;1610811;16182515;16268778;16339447;1655761;16754659;16822840;16923326;1698554;1710450;1710578;1719979;1722333;1748288;17623675;18127230;18434541;1847994;18515384;18577758;18644867;18936096;1905813;19524539;19608861;20460180;21486943;2178974;21965087;22647378;23159739;23190890;23207919;23446738;23690594;24906252;2509452;25248477;25595898;2649896;27128622;27496565;27535533;28394346;2841328;29295999;29557506;30804224;3086311;3202875;32589590;32636443;33537832;3366244;33744299;34140478;35051231;3525564;36542159;37770430;3856870;39174539;5338216;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;7958932;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8336698;8373420;8381365;8383682;8395824;8440682;8463333;8503909;8615752;8630503;8664309;8666380;8702752;873923;8823230;9171878;9199364;9284755;9305846;9353119;9359036;9359047;9440696;9521323;9530155;9560246;9593744;9607765;9676189;9685625;9722565;9760192;9770463;9792798;9832121;9851594;9973413",
        "class_list": "",
        "function": "Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue. Publication Status: Online-Only, [RefSeq, PubMed]; Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer., [RefSeq, PubMed]; Endothelins are endothelium-derived vasoconstrictor peptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Insights into Endothelin-3 and Multiple Sclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; MiR27a3p regulates the inhibitory influence of endothelin 3 on the tumorigenesis of papillary thyroid cancer cells. Erratum:[Mol Med Rep. 2021 Jun;23(6):466. doi: 10.3892/mmr.2021.12105. PMID: 33880586], [RefSeq, PubMed]; The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P5I5;Q03229;Q7Z6D2;Q9UGT7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0031708 endothelin B receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0007267 cell-cell signaling;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 18.4,
        "record_id": "P14138-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P37173-1",
        "uniprot_id": "TGFR2_HUMAN",
        "mass": 64568.0,
        "length": 567,
        "protein_name": "TGF-beta receptor type-2",
        "gene_name": "TGFBR2",
        "organism": "Human",
        "refseq_name": "TGF-beta receptor type-2 isoform A precursor",
        "refseq_ac": "NP_001020018",
        "gene_names_uniprotkb": "TGFBR2",
        "gene_names_refseq": "AAT3; FAA3; LDS1B; LDS2B; LDS2; MFS2; RIIC; TAAD2; TBR-ii; TBRII; TGFBR2; TGFR-2; TGFbeta-RII; tbetaR-II",
        "protein_names_uniprotkb": "TGF-beta receptor type-2; 2.7.11.30; TGF-beta receptor type II; TGF-beta type II receptor; TGFR-2; TbetaR-II; Transforming growth factor-beta receptor type II",
        "protein_names_refseq": "TGF-beta receptor type IIB; TGF-beta receptor type-2 isoform A precursor; TGF-beta receptor type-2; TGF-beta type II receptor; transforming growth factor beta receptor II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II epsilon; transforming growth factor, beta receptor II gamma",
        "tax_id": 9606,
        "disease": "Loeys-Dietz syndrome (Disease Ontology:DOID:0050466); small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); Loeys-Dietz syndrome 2 (Disease Ontology:DOID:0070234); hereditary nonpolyposis colorectal cancer type 6 (Disease Ontology:DOID:0070273); cleft soft palate (Disease Ontology:DOID:0110214); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); DiGeorge syndrome (Disease Ontology:DOID:11198); Marfan syndrome (Disease Ontology:DOID:14323); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); arteriosclerosis (Disease Ontology:DOID:2349); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pulmonary fibrosis (Disease Ontology:DOID:3770); Lynch syndrome (Disease Ontology:DOID:3883); vasculogenic impotence (Disease Ontology:DOID:4762); cholangiocarcinoma (Disease Ontology:DOID:4947); esophageal cancer (Disease Ontology:DOID:5041); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:7048);  (R-HSA-2173788);  (R-HSA-2173789);  (R-HSA-2173791);  (R-HSA-3304356);  (R-HSA-3642279);  (R-HSA-3645790);  (R-HSA-3656532);  (R-HSA-3656535);  (R-HSA-5689603);  (R-HSA-9839389)",
        "pathway_count": 11,
        "publication_count": 157,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10519551;10757800;10789724;10877843;11100470;11141505;11158580;11163210;11212236;11237011;11278251;11323414;11390472;11447115;11483955;11586295;11850637;12121646;12151385;12202987;12482908;12519765;12939140;12941698;12953056;12958365;1310899;1333888;14657501;14701756;14718519;15235604;15340161;15350224;15496141;15564041;15731757;15761148;15781469;16027248;16027725;16061177;16251899;16906146;16959974;16982625;17081983;17139257;17344846;17440088;18243111;18469808;18497827;18578522;18691976;19114990;19188440;19533785;19720988;19758997;19815555;19883511;20061380;20101701;20129061;20207738;20358619;20436459;20625381;20805357;20937913;21258369;21358634;21441952;21791611;21949523;22045334;22113417;22344298;23139211;23186163;23290524;23525077;23584533;24190977;24275569;24715725;2530630;25576301;25893292;26992070;27726376;28467828;29391424;29493099;29557506;29632711;29786170;30429286;31844290;32157095;32488085;32938616;32983136;33091337;33592498;33968037;34357683;34405274;34568316;35051231;36284347;37074911;37938771;38452473;38729557;38730107;39333849;7665626;7693660;7737999;7761852;7774578;7823948;7959019;8047140;8072530;8145827;8242743;8252616;8261515;8484121;8555189;8635485;8812462;8840968;8947046;8973329;8980228;9155023;9169454;9215638;9233797;9311995;9335507;9346966;9354786;9472030;9528852;9590282;9679059;9790970;9856985;9865696;9927040",
        "class_list": "",
        "function": "Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1., [UniProtKB, PubMed]; CD9 promotes TbetaR2-TbetaR1 association driving the transition of human dermal fibroblasts to myofibroblast under hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]; Has transforming growth factor beta-activated receptor activity., [UniProtKB, PubMed]; ITGB5 facilitates gastric cancer metastasis by promoting TGFBR2 endosomal recycling., [RefSeq, PubMed]; Molecular insights into gastric cancer: The impact of TGFBR2 and hsa-mir-107 revealed by microarray sequencing and bioinformatics., [RefSeq, PubMed]; Polymorphism of Transforming Growth Factor TGFB and Its Receptors TGFBRI, TGFBRII, TGFBRIIII Genes in Western Siberia Patients with Open-Angle Glaucoma., [RefSeq, PubMed]; The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]., [RefSeq]; Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways., [UniProtKB, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 74,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 12,
        "disease_count": 25,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DTV5;Q15580;Q6DKT6;Q99474",
        "ec_number_list": "2.7.11.30;2.3.2.27;3.1.3.16;2.3.2.34;2.3.2.23;3.6.5.2;3.1.3.53;5.2.1.8;2.7.11.1;2.7.11.13;2.3.2.26;2.3.2.36;3.4.19.12",
        "go_molecular_function": "GO:0019209 kinase activator activity;GO:0034714 type III transforming growth factor beta receptor binding;GO:0060090 molecular adaptor activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0002666 positive regulation of T cell tolerance induction;GO:0035162 embryonic hemopoiesis;GO:0001570 vasculogenesis;GO:0007399 nervous system development;GO:0007507 heart development",
        "synthesized_glycan_count": 0,
        "hit_score": 17.6,
        "record_id": "P37173-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P46777-1",
        "uniprot_id": "RL5_HUMAN",
        "mass": 34363.0,
        "length": 297,
        "protein_name": "Large ribosomal subunit protein uL18",
        "gene_name": "RPL5",
        "organism": "Human",
        "refseq_name": "large ribosomal subunit protein uL18",
        "refseq_ac": "NP_000960",
        "gene_names_uniprotkb": "RPL5; MSTP030",
        "gene_names_refseq": "L5; MSTP030; PPP1R135; RPL5; uL18",
        "protein_names_uniprotkb": "Large ribosomal subunit protein uL18; 60S ribosomal protein L5",
        "protein_names_refseq": "60S ribosomal protein L5; large ribosomal subunit protein uL18; protein phosphatase 1, regulatory subunit 135",
        "tax_id": 9606,
        "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); Diamond-Blackfan anemia 6 (Disease Ontology:DOID:0111879); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); glioblastoma (Disease Ontology:DOID:3068); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)",
        "pathway": " (hsa:6125);  (R-HSA-156827);  (R-HSA-156902);  (R-HSA-1799339);  (R-HSA-192823);  (R-HSA-2408557);  (R-HSA-6791226);  (R-HSA-72689);  (R-HSA-72706);  (R-HSA-72764);  (R-HSA-9010553);  (R-HSA-9633012);  (R-HSA-975956);  (R-HSA-975957);  (R-HSA-9954709);  (R-HSA-9954714);  (R-HSA-9954716)",
        "pathway_count": 17,
        "publication_count": 327,
        "publication_id_list": "10358005;10659855;1095581;10958351;10970870;10982836;11018020;11018027;11237011;11265756;11331269;11532962;11544179;11546874;11551508;11677247;11691921;11726970;11922599;11964406;12068309;12150911;12417715;12493757;12554878;12588972;12718880;12832468;12853463;12962325;1400365;14527413;14567916;14630918;14636577;14654843;14742663;14973490;14978097;15034551;15104674;15317934;15385533;15469983;15534230;15546618;15721257;15775988;15781252;15821744;15944288;16026328;16037817;16043514;16186820;16209946;16284618;16452507;16469117;16601204;16622410;16630668;16738141;16989641;17053788;17142313;17189298;17267404;17287340;17352659;17353269;17363904;17412707;17726049;17803942;17893241;18065403;18066079;18166647;18230761;18256688;18285520;18423202;18438418;18447580;18447585;18455985;18524595;18539146;1856230;1861871;18657639;18974281;18991276;19060897;19061985;19106111;19150429;19191325;19332556;19359157;19417104;19478851;19503078;19556969;19564402;19608861;19608919;19706539;19801658;19859661;19909264;20023408;20038530;20056613;2006156;20068231;20361218;20444697;20479275;20531386;20691628;20798176;20805244;20817927;20819938;20926688;20930030;21029861;21036871;21063389;21097556;21136679;21145460;21406692;21419344;21740066;21872626;22072790;22121020;22190735;22195017;22424782;22544926;22645359;22898188;22916032;23085078;23186163;23217742;23234702;23269699;23439679;23481700;23482395;23636399;23685075;23746841;2388630;24029068;24120868;24129315;24424021;24524803;24550520;24714562;24715725;25114211;25132172;25242263;25418920;25525153;25576301;25578875;25645385;25802875;25880248;25892735;25969445;26154972;26237581;26375851;26728094;26758079;26811146;26992070;27397612;27452731;27526673;27543614;27600516;27846572;27862975;27920218;28063628;28065601;28132843;28228285;28467828;28514659;28649982;28685749;28832583;28834231;28855257;28860189;28904123;29242379;29331515;29371260;29393594;29413899;29493099;29508533;29557506;29632046;29632312;29632711;29786170;30244831;30293783;30315122;30429286;30444036;30484775;30524438;30573663;30779550;30804176;30833945;31011209;31154438;31217245;31222486;31530632;31844290;31848261;31937595;31998317;32099016;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32579943;32669547;32870666;32897882;32938616;32983136;33043033;33091337;33123756;33141586;33214551;33298915;33392160;33406423;33537174;33592498;33691108;33717175;33909987;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34185709;34211107;34290406;34357683;34405274;34509645;34561969;34725712;35051231;35083852;35138101;35251023;35318648;35321919;35561310;35580925;35864588;36010968;36215666;36241641;36284347;36302773;36384455;36581221;37217939;37291423;37676773;37938771;38665916;39990658;429297;592398;592399;641056;6568109;6901506;7772601;7937132;7990965;8336711;8407925;8806611;8890909;9211906;9234479;9431993;9482744;9631292;9637248;9687515;9712840",
        "class_list": "",
        "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer., [RefSeq, PubMed]; Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly. Publication Status: Online-Only, [RefSeq, PubMed]; Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18P family of ribosomal proteins and component of the 60S subunit. The encoded protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The encoded protein may also function to inhibit tumorigenesis through the activation of downstream tumor suppressors and the downregulation of oncoprotein expression. Mutations in this gene have been identified in patients with Diamond-Blackfan Anemia (DBA). This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Mar 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q32LZ3;Q53HH6;Q9H3F4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0031625 ubiquitin protein ligase binding;GO:0003730 mRNA 3'-UTR binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0008097 5S rRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0006412 translation",
        "synthesized_glycan_count": 0,
        "hit_score": 33.0,
        "record_id": "P46777-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NEL9-1",
        "uniprot_id": "DDHD1_HUMAN",
        "mass": 100435.0,
        "length": 900,
        "protein_name": "Phospholipase DDHD1",
        "gene_name": "DDHD1",
        "organism": "Human",
        "refseq_name": "phospholipase DDHD1 isoform b",
        "refseq_ac": "NP_001153619",
        "gene_names_uniprotkb": "DDHD1; KIAA1705",
        "gene_names_refseq": "DDHD1; PA-PLA1; PAPLA1; SPG28; iPLA1I; iPLA1alpha",
        "protein_names_uniprotkb": "Phospholipase DDHD1; 3.1.1.111; 3.1.1.118; 3.1.1.32; DDHD domain-containing protein 1; PA-PLA1; Phosphatidic acid-preferring phospholipase A1 homolog; Phospholipid sn-1 acylhydrolase",
        "protein_names_refseq": "intracellular phospholipase A1 alpha; phosphatidic acid-preferring phospholipase A1 homolog; phosphatidic acid-preferring phospholipase A1-like protein; phospholipase DDHD1 isoform b; phospholipase DDHD1; phospholipid sn-1 acylhydrolase; spastic paraplegia 28 (autosomal recessive)",
        "tax_id": 9606,
        "disease": "hereditary spastic paraplegia 28 (Disease Ontology:DOID:0110779); hereditary spastic paraplegia 54 (Disease Ontology:DOID:0110806)",
        "pathway": " (hsa:80821);  (R-HSA-1483166)",
        "pathway_count": 2,
        "publication_count": 105,
        "publication_id_list": "10455175;10506173;10553003;10681567;11031251;11112443;11237011;11328814;11788596;11830583;12063250;12161451;12359733;12522102;12963729;14573790;15367102;15623529;16460752;16495223;16620771;16704971;16864775;17028579;17170135;17707131;18238778;18718904;19336658;19666841;20359546;20705608;21173190;22645359;22777291;22922100;23176821;23176823;23186163;23301498;23481700;23807634;24599962;24714562;24715725;24966474;25418920;25880248;26375851;26711011;26811146;26992070;28228285;28411811;28832583;28904123;29242379;2925608;29437277;29493099;29557506;29769354;29786170;30315122;30379171;31217245;31844290;31937595;32157095;32161166;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33717175;33912179;33952459;33968037;34089703;34211107;34357683;3458202;35051231;35580925;36010968;37189713;7060561;7821823;8163052;8186247;8300559;8530346;8687421;9188469;9212163;9461603;9488669;9582313",
        "class_list": "",
        "function": "Expression of Lysophosphatidylinositol Signaling-relevant Molecules in Colorectal Cancer., [RefSeq, PubMed]; Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Phosphorylation of human phospholipase A1 DDHD1 at newly identified phosphosites affects its subcellular localization., [RefSeq, PubMed]; This gene is a member of the intracellular phospholipase A1 gene family. The protein encoded by this gene preferentially hydrolyzes phosphatidic acid. It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. Overexpression of this gene causes fragmentation of the tubular structures in mitochondria, while depletion of the gene results in mitochondrial tubule elongation. Deletion of this gene in male mice caused fertility defects, resulting from disruption in the organization of the mitochondria during spermiogenesis. In humans, mutations in this gene have been associated with hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease, or, familial spastic paraparesis (FSP). This inherited disorder is characterized by progressive weakness and spasticity of the legs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G5E9D1;Q8WVH3;Q96LL2;Q9C0F8",
        "ec_number_list": "3.1.1.-;3.1.1.3;3.1.1.32;3.1.1.34;3.1.1.5;3.1.1.4;2.3.1.-;3.1.1.111;3.1.1.118",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004620 phospholipase activity;GO:0008970 phospholipase A1 activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0046488 phosphatidylinositol metabolic process;GO:0090141 positive regulation of mitochondrial fission",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q8NEL9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N3F8-1",
        "uniprot_id": "MILK1_HUMAN",
        "mass": 93441.0,
        "length": 863,
        "protein_name": "MICAL-like protein 1",
        "gene_name": "MICALL1",
        "organism": "Human",
        "refseq_name": "MICAL-like protein 1 isoform 3",
        "refseq_ac": "NP_203744",
        "gene_names_uniprotkb": "MICALL1; KIAA1668; MIRAB13",
        "gene_names_refseq": "MICAL-L1; MICALL1; MIRAB13",
        "protein_names_uniprotkb": "MICAL-like protein 1; MIRab13; Molecule interacting with Rab13",
        "protein_names_refseq": "MICAL-like protein 1 isoform 3; MICAL-like protein 1; molecule interacting with Rab13",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:85377)",
        "pathway_count": 1,
        "publication_count": 59,
        "publication_id_list": "11237011;11258795;12110185;15302935;16959974;17081983;17322306;18212344;18477386;18669648;19413330;19651622;19664994;19664995;19690332;19864458;20058876;20068231;20106972;20801876;21795389;21951725;23186163;23301498;23596323;25505266;25576301;26992070;27600516;27862975;28832583;28834231;28904123;29242379;29557506;29632711;30192525;30429286;30779550;30784271;31154438;31615969;31844290;32157095;32161166;32488085;32502341;32938616;33298915;33592498;33912179;33968037;34100897;34932366;35051231;35580925;36010968;36215666;39382837",
        "class_list": "",
        "function": "Endosomal actin branching, fission, and receptor recycling require FCHSD2 recruitment by MICAL-L1., [RefSeq, PubMed]; Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MICAL-L1 is required for cargo protein delivery to the cell surface., [RefSeq, PubMed]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 7,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 38,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5TI16;Q7RTP5;Q8N3N8;Q9BVL9;Q9BY92;Q9UH43;Q9UH44;Q9UH45",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0045296 cadherin binding;GO:0008093 cytoskeletal anchor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005929 cilium;GO:0030054 cell junction",
        "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0031175 neuron projection development;GO:0006612 protein targeting to membrane;GO:0030036 actin cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q8N3F8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NR90-1",
        "uniprot_id": "DAZ3_HUMAN",
        "mass": 54989.0,
        "length": 486,
        "protein_name": "Deleted in azoospermia protein 3",
        "gene_name": "DAZ3",
        "organism": "Human",
        "refseq_name": "deleted in azoospermia protein 3",
        "refseq_ac": "NP_065097",
        "gene_names_uniprotkb": "DAZ3",
        "gene_names_refseq": "DAZ3; pDP1679",
        "protein_names_uniprotkb": "Deleted in azoospermia protein 3",
        "protein_names_refseq": "deleted in azoospermia protein 3",
        "tax_id": 9606,
        "disease": "Y-linked spermatogenic failure 2 (Disease Ontology:DOID:0070187)",
        "pathway": " (hsa:57054)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "10857750;10903443;10936047;11058556;11095434;11237011;11390979;12511597;12752250;12801575;17416365;19223287;26232607;31217245;31429579",
        "class_list": "",
        "function": "AZFc subdeletions do not seem to cause severe impairment of spermatogenesis in Chilean men., [RefSeq, PubMed]; All four DAZ genes are expressed in the human testis, and their products are highly polymorphic among men, [RefSeq, PubMed]; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation., [UniProtKB]; Studies indicate that partial RNA-binding proteins DAZ1/2 deletion was associated wih male infertility, but partial RNA-binding proteins DAZ3/4 deletion was not associated with male infertility. Review article, [RefSeq, PubMed]; This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2KHN7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008494 translation activator activity;GO:0003730 mRNA 3'-UTR binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0045948 positive regulation of translational initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q9NR90-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TF09-1",
        "uniprot_id": "DLRB2_HUMAN",
        "mass": 10855.0,
        "length": 96,
        "protein_name": "Dynein light chain roadblock-type 2",
        "gene_name": "DYNLRB2",
        "organism": "Human",
        "refseq_name": "dynein light chain roadblock-type 2 isoform 1",
        "refseq_ac": "NP_570967",
        "gene_names_uniprotkb": "DYNLRB2; DNCL2B; DNLC2B; ROBLD2",
        "gene_names_refseq": "DNCL2B; DNLC2B; DYNLRB2; ROBLD2",
        "protein_names_uniprotkb": "Dynein light chain roadblock-type 2; Dynein light chain 2B, cytoplasmic; Roadblock domain-containing protein 2",
        "protein_names_refseq": "bithoraxoid-like protein; dynein light chain 2B, cytoplasmic; dynein light chain roadblock-type 2 isoform 1; dynein, cytoplasmic, light polypeptide 2B; roadblock domain-containing protein 2; testicular tissue protein Li 53",
        "tax_id": 9606,
        "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:83657);  (R-HSA-5620924)",
        "pathway_count": 2,
        "publication_count": 59,
        "publication_id_list": "10069812;11237011;11285270;11750132;12077152;12795688;15231740;15269286;15489852;15523559;15955805;16049494;16435301;16492809;16775004;16782012;17312020;17314406;17574030;18180368;18304522;18364699;18369462;18852297;19112494;19147001;19253336;19384852;19450523;19720863;19805633;20435895;20526327;20526328;20530210;20889716;21427764;21936775;22118932;22922713;22992454;23945166;23990561;24140113;24296415;24596149;24616010;25205765;25349261;25443296;29485866;33968037;35051231;8516294;8522608;9114011;9585416;9585417;9852153",
        "class_list": "",
        "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules., [UniProtKB]; Among the total 68 liver cancer samples tested, DNLC2B was down-regulated in 28 cases., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003777 microtubule motor activity;GO:0045505 dynein intermediate chain binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005929 cilium;GO:0001673 male germ cell nucleus",
        "go_biological_process": "GO:0007018 microtubule-based movement;GO:0032388 positive regulation of intracellular transport;GO:0035721 intraciliary retrograde transport;GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q8TF09-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z2Z2-1",
        "uniprot_id": "EFL1_HUMAN",
        "mass": 125430.0,
        "length": 1120,
        "protein_name": "Elongation factor-like GTPase 1",
        "gene_name": "EFL1",
        "organism": "Human",
        "refseq_name": "elongation factor-like GTPase 1 isoform 2",
        "refseq_ac": "NP_001035700",
        "gene_names_uniprotkb": "EFL1; EFTUD1; FAM42A",
        "gene_names_refseq": "EFL1; EFTUD1; FAM42A; HsT19294; RIA1; SDS2",
        "protein_names_uniprotkb": "Elongation factor-like GTPase 1; 3.6.5.-; Elongation factor Tu GTP-binding domain-containing protein 1; Elongation factor-like 1; Protein FAM42A",
        "protein_names_refseq": "elongation factor Tu GTP binding domain containing 1; elongation factor Tu GTP-binding domain-containing protein 1; elongation factor-like 1; elongation factor-like GTPase 1 isoform 2; ribosome assembly 1 homolog",
        "tax_id": 9606,
        "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); Shwachman-Diamond syndrome 2 (MONDO:MONDO:0044205)",
        "pathway": " (hsa:79631)",
        "pathway_count": 1,
        "publication_count": 55,
        "publication_id_list": "11237011;19608861;20068231;20966410;21536732;23301498;25015090;25576301;25991726;26154972;26479198;26992070;27846572;27862975;28331068;28904123;29437277;29493099;29557506;30379171;30410026;30429286;30484775;30545121;31092671;31151987;31838967;31844290;32157095;32350084;32357974;32897882;32938616;32983136;33298915;33392160;33592498;33633747;33717175;33912179;33968037;34087483;34115847;34357683;34509645;35051231;35318648;35561310;35580925;35705054;36010968;36215666;36241641;37938771;40307207",
        "class_list": "",
        "function": "Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics., [RefSeq, PubMed]; GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Somatic uniparental disomy mitigates the most damaging EFL1 allele combination in Shwachman-Diamond syndrome. Erratum:[Blood. 2023 Aug 31;142(9):857. doi: 10.1182/blood.2023021819. PMID: 37651154], [RefSeq, PubMed]; The effect of SBDS mutations on the interaction with EFL1were tested, and showed that all tested mutations disrupted the binding to EFL1. Publication Status: Online-Only, [RefSeq, PubMed]; We report biallelic mutations in EFL1 in 3 unrelated individuals with clinical features of SDS. Cellular defects in these individuals include impaired ribosomal subunit joining and attenuated global protein translation as a consequence of defective eIF6 eviction., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NKY5;B7Z6I0;Q9H8Z6",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4;2.7.11.1;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0046039 GTP metabolic process;GO:0042256 cytosolic ribosome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "Q7Z2Z2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86YB7-1",
        "uniprot_id": "ECHD2_HUMAN",
        "mass": 31126.0,
        "length": 292,
        "protein_name": "Enoyl-CoA hydratase domain-containing protein 2, mitochondrial",
        "gene_name": "ECHDC2",
        "organism": "Human",
        "refseq_name": "enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform 1",
        "refseq_ac": "NP_001185890",
        "gene_names_uniprotkb": "ECHDC2",
        "gene_names_refseq": "ECHDC2",
        "protein_names_uniprotkb": "Enoyl-CoA hydratase domain-containing protein 2, mitochondrial",
        "protein_names_refseq": "enoyl Coenzyme A hydratase domain containing 2; enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform 1; enoyl-CoA hydratase domain-containing protein 2, mitochondrial",
        "tax_id": 9606,
        "disease": "3-methylglutaconic aciduria type 1 (Disease Ontology:DOID:0110002)",
        "pathway": " (hsa:55268)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;29557506;31844290;32387766;34509645;34932366;38783226",
        "class_list": "",
        "function": "ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DQ36;Q9NV38",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0004300 enoyl-CoA hydratase activity",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006635 fatty acid beta-oxidation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q86YB7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZUT9-1",
        "uniprot_id": "DEN5B_HUMAN",
        "mass": 145020.0,
        "length": 1274,
        "protein_name": "DENN domain-containing protein 5B",
        "gene_name": "DENND5B",
        "organism": "Human",
        "refseq_name": "DENN domain-containing protein 5B isoform 2",
        "refseq_ac": "NP_001295268",
        "gene_names_uniprotkb": "DENND5B",
        "gene_names_refseq": "DENND5B",
        "protein_names_uniprotkb": "DENN domain-containing protein 5B; Rab6IP1-like protein",
        "protein_names_refseq": "DENN domain-containing protein 5B isoform 2; DENN domain-containing protein 5B; DENN/MADD domain containing 5B; rab6IP1-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:160518);  (R-HSA-8876198)",
        "pathway_count": 2,
        "publication_count": 229,
        "publication_id_list": "10818110;10990452;11038176;11179213;11237011;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18669648;18701652;18707149;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19620288;19656848;19725050;19729655;19745841;20008558;20068231;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22424782;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23186163;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23481700;23645161;23678941;23684622;23713133;23839779;24275569;24296415;24644286;24694596;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25472813;25576301;25645385;25648148;25713415;25925668;26055712;26177209;26245486;26374642;26434594;26538022;26925400;26936971;26992070;27041585;27044746;27103185;27246931;27329675;27920218;28218747;28832583;29242379;29393594;29437277;29557506;30410026;31844290;32157095;32357974;32387766;32897882;32938616;32983136;33141586;33298915;33691108;33717175;33912179;33968037;33981976;34087483;34171305;34211107;34405274;34932366;35051231;35318648;35494241;35561310;35580925;36010968;36215666;36241641;38387458;7688123;7911226;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "De novo variants in DENND5B cause a neurodevelopmental disorder., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 1,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5ME75;Q59FW8;Q68CZ7;Q6NUJ0;Q7Z3F9;Q8N973;Q8WUC8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:1905885 positive regulation of triglyceride transport",
        "synthesized_glycan_count": 0,
        "hit_score": 23.2,
        "record_id": "Q6ZUT9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75140-10",
        "uniprot_id": "DEPD5_HUMAN",
        "mass": 181264.0,
        "length": 1603,
        "protein_name": "GATOR1 complex protein DEPDC5",
        "gene_name": "DEPDC5",
        "organism": "Human",
        "refseq_name": "GATOR1 complex protein DEPDC5 isoform 2",
        "refseq_ac": "NP_001007189",
        "gene_names_uniprotkb": "DEPDC5; KIAA0645",
        "gene_names_refseq": "DEE111; DEP.5; DEPDC5; FFEVF1; FFEVF; FPEVF",
        "protein_names_uniprotkb": "GATOR1 complex protein DEPDC5; DEP domain-containing protein 5",
        "protein_names_refseq": "DEP domain-containing protein 5; GATOR complex protein DEPDC5; GATOR1 complex protein DEPDC5 isoform 2; GATOR1 complex protein DEPDC5",
        "tax_id": 9606,
        "disease": "developmental and epileptic encephalopathy 111 (Disease Ontology:DOID:0051083); familial focal epilepsy with variable foci (Disease Ontology:DOID:0081420); familial focal epilepsy with variable foci 1 (Disease Ontology:DOID:0081421); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); cancer (Disease Ontology:DOID:162); epilepsy (Disease Ontology:DOID:1826); focal epilepsy (Disease Ontology:DOID:2234)",
        "pathway": " (hsa:9681);  (R-HSA-9639288)",
        "pathway_count": 2,
        "publication_count": 95,
        "publication_id_list": "15770670;15854902;15878852;16098514;17470430;18497260;18604198;20381137;21725309;22053050;22575674;22980980;23481700;23542697;23542701;23723238;24081491;24095279;24275569;24283814;24591017;24715725;25259925;25263562;25366275;25457612;25561175;25567906;25576301;25819761;25892735;26154972;26449471;26505888;26586190;26972053;26992070;27173016;27308486;27487210;27648300;27846572;28066558;28199306;28199315;28657654;28832583;28834231;28904123;29053970;29056322;29123071;29236692;29242379;29393594;29557506;29590090;29632711;29769354;29769719;30061680;30181260;30410026;30651352;30779550;31154438;31217245;31530632;31548394;31717259;31844290;31848261;31998317;32157095;32357974;32387766;32502341;32938616;32983136;33298915;33392160;33717175;33912179;34509645;34561969;34932366;35051231;35338845;35580925;36010968;36067010;37003255;37259768;37984419;7499430",
        "class_list": "",
        "function": "As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Clinical Course May Be Independent from Neuroimaging in DEPDC-5-Related Epilepsy., [RefSeq, PubMed]; Mutations in DEPDC5 cause familial focal epilepsy with variable foci., [RefSeq, PubMed, PubMed]; Seizure Control Outcomes following Resection of Cortical Dysplasia in Patients with DEPDC5 Variants: A Systematic Review and Individual Patient Data Analysis., [RefSeq, PubMed]; Seizure features and outcomes in 50 children with GATOR1 variants: A retrospective study, more favorable for epilepsy surgery. Review article, [RefSeq, PubMed]; This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]., [RefSeq]; Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 23,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8V6;A8MPX9;B4DH93;B9EGN9;Q5K3V5;Q5THY9;Q5THZ0;Q5THZ1;Q5THZ3;Q68DR1;Q6MZX3;Q6PEZ1;Q9UGV8;Q9UH13",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:1990130 GATOR1 complex",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0010508 positive regulation of autophagy;GO:0034198 cellular response to amino acid starvation;GO:1904262 negative regulation of TORC1 signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 9.8,
        "record_id": "O75140-10",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9GZP9-1",
        "uniprot_id": "DERL2_HUMAN",
        "mass": 27567.0,
        "length": 239,
        "protein_name": "Derlin-2",
        "gene_name": "DERL2",
        "organism": "Human",
        "refseq_name": "derlin-2 isoform c",
        "refseq_ac": "NP_001291708",
        "gene_names_uniprotkb": "DERL2; CGI-101; DER2; FLANA; SBBI53",
        "gene_names_refseq": "CGI-101; DERL2; DERtrin-2; F-LAN-1; F-LANa; FLANa; derlin-2",
        "protein_names_uniprotkb": "Derlin-2; DERtrin-2; Degradation in endoplasmic reticulum protein 2; Der1-like protein 2; F-LAN-1; F-LANa",
        "protein_names_refseq": "Der1-like domain family, member 2; carcinoma related; degradation in endoplasmic reticulum protein 2; derlin-2 isoform c",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51009);  (R-HSA-382556);  (R-HSA-5358346);  (R-HSA-5362768);  (R-HSA-5678895);  (R-HSA-901032);  (R-HSA-9931269)",
        "pathway_count": 7,
        "publication_count": 157,
        "publication_id_list": "10409699;10484077;10665657;10694380;10748049;10984056;11146634;11237011;11486055;11500051;11504826;11562789;11812794;12379217;12379510;12403779;12604685;12913004;1352877;1356264;1359686;1377674;14661924;15075292;15163793;15175422;15215855;15292211;15472518;15611333;15713668;15863492;15899824;16186509;16282375;16335952;16431915;16449189;16611729;16816140;16901789;1695717;17126548;17507410;17523162;17855752;17894550;17977821;18003979;18264092;18282684;18417469;18426978;18434309;18502753;18534984;18711132;18716059;19002207;19081070;19084021;19346256;19447222;19570978;19603532;1968359;19862647;1998343;20104595;20583968;20585641;20621639;21083385;21257310;2135388;21357747;21652558;22016385;22047557;2210768;22178883;22318583;2236053;23063411;23112049;23232094;23719536;23867461;24019521;24685677;2475911;24784881;25092655;25133187;25584290;2570070;2570460;25892735;26208431;26565908;26992070;28132103;28218747;28510447;28514659;28832583;28904123;2898143;29055231;29167172;29242379;29393594;29437277;29493099;29557506;29632046;29769354;30118680;30315122;30334692;30334693;30779550;31154438;31217245;31679946;31844290;31848261;32157095;32938616;32981041;33912179;33968037;33980593;34561969;3457471;3472246;35051231;35318648;35580925;36010968;36284347;37815698;37938771;7523390;7529176;7553863;7553864;7865904;7885476;7985023;8689684;8824192;8896571;9593755;9652413;9816258;9831708",
        "class_list": "",
        "function": "(Microbial infection) In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses., [UniProtKB, PubMed]; DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma., [RefSeq, PubMed]; Derlin-2 forms a robust multiprotein complex with the p97 AAA ATPase as well as the mammalian orthologs of the yeast Hrd1p/Hrd3p ubiquitin-ligase complex, and participates in the degradation of proteins from the ER., [RefSeq, PubMed]; Derlin-2 is part of a protein quality control mechanism that can rescue glomerular injury attributable to impaired protein folding pathways in the endoplasmic reticulum., [RefSeq, PubMed]; Endoplasmic Reticulum-Associated Degradation Controls Virus Protein Homeostasis, Which Is Required for Flavivirus Propagation., [RefSeq, PubMed]; Findings indicate that Derlin-2 provides the missing link between EDEM and p97 in the process of degrading misfolded glycoproteins., [RefSeq, PubMed]; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins (PubMed:16186509, PubMed:16449189). May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908)., [UniProtKB, PubMed, PubMed, PubMed]; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9Y3A7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005047 signal recognition particle binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005770 late endosome",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 16.0,
        "record_id": "Q9GZP9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZR08-1",
        "uniprot_id": "DYH12_HUMAN",
        "mass": 356942.0,
        "length": 3092,
        "protein_name": "Dynein axonemal heavy chain 12",
        "gene_name": "DNAH12",
        "organism": "Human",
        "refseq_name": "dynein axonemal heavy chain 12 isoform 2",
        "refseq_ac": "NP_940966",
        "gene_names_uniprotkb": "DNAH12; DHC3; DLP12; DNAH12L; DNAH7L; DNAHC3; DNHD2; HDHC3; HL19",
        "gene_names_refseq": "DHC3; DLP12; DLP3; DNAH12L; DNAH12; DNAH7L; DNAHC12; DNAHC3; DNHD2; HDHC3; HL-19; HL19; SPGF100",
        "protein_names_uniprotkb": "Dynein axonemal heavy chain 12; Axonemal beta dynein heavy chain 12; Axonemal dynein heavy chain 12-like protein; Axonemal dynein heavy chain 7-like protein; Ciliary dynein heavy chain 12; Dynein axonemal heavy chain 7-like; Dynein heavy chain domain-containing protein 2",
        "protein_names_refseq": "axonemal beta dynein heavy chain 12; axonemal dynein heavy chain isotype3; ciliary dynein heavy chain 12; dynein axonemal heavy chain 12 isoform 2; dynein heavy chain domain-containing protein 2; dynein, axonemal, heavy polypeptide 12; dynein, heavy chain-5",
        "tax_id": 9606,
        "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); spermatogenic failure 100 (Disease Ontology:DOID:0070729); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871); pulmonary tuberculosis (Disease Ontology:DOID:2957); renal cell carcinoma (Disease Ontology:DOID:4450); renal carcinoma (Disease Ontology:DOID:4451); Hodgkin's lymphoma (Disease Ontology:DOID:8567); pulmonary emphysema (Disease Ontology:DOID:9675)",
        "pathway": " (hsa:201625)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;17173037;17283181;29557506;31844290;32387766;32502341;32938616;32983136;33392160;34791246;35051231;36215666;37217939;37258679;39071892;40146200;8666668",
        "class_list": "",
        "function": "Dynein will initiate translocation of late endosomes to microtubule minus ends only after interacting with betaIII spectrin, which requires the activities of Rab7-RILP and ORP1L., [RefSeq, PubMed]; Involved in spermiogenesis. Plays a role in the proper organization of axoneme in sperm flagella, but not in cilia, by recruiting DNAH1 and DNALI1 to flagellum., [UniProtKB, PubMed, UniProtKB, UniProtKB]; We show that EGF relocates to the cell centre in a dynein-dependent fashion, concomitant with the sorting away of transferrin receptor, although it remains in Rab5-positive early endosomes., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 55,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 18,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NGI2;Q6ZTR8;Q8N7R9;Q8WXK2;Q92816",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding",
        "go_cellular_component": "GO:0005874 microtubule;GO:0036126 sperm flagellum;GO:0005858 axonemal dynein complex;GO:0030286 dynein complex;GO:0031514 motile cilium",
        "go_biological_process": "GO:0007286 spermatid development;GO:0007288 sperm axoneme assembly;GO:0070286 axonemal dynein complex assembly;GO:0007018 microtubule-based movement;GO:0003341 cilium movement",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q6ZR08-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14126-1",
        "uniprot_id": "DSG2_HUMAN",
        "mass": 122294.0,
        "length": 1118,
        "protein_name": "Desmoglein-2",
        "gene_name": "DSG2",
        "organism": "Human",
        "refseq_name": "desmoglein-2 preproprotein",
        "refseq_ac": "NP_001934",
        "gene_names_uniprotkb": "DSG2; CDHF5",
        "gene_names_refseq": "CDHF5; DSG2; HDGC",
        "protein_names_uniprotkb": "Desmoglein-2; Cadherin family member 5; HDGC",
        "protein_names_refseq": "cadherin family member 5; desmoglein-2 preproprotein",
        "tax_id": 9606,
        "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); arrhythmogenic right ventricular dysplasia 10 (Disease Ontology:DOID:0110081); dilated cardiomyopathy 1BB (Disease Ontology:DOID:0110458); hypertension (Disease Ontology:DOID:10763); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); glaucoma (Disease Ontology:DOID:1686); congestive heart failure (Disease Ontology:DOID:6000); chronic kidney disease (Disease Ontology:DOID:784); multiple myeloma (Disease Ontology:DOID:9538)",
        "pathway": " (hsa:1829);  (R-HSA-351906);  (R-HSA-6805567);  (R-HSA-6809371);  (R-HSA-9013404);  (R-HSA-9013408);  (R-HSA-9013423)",
        "pathway_count": 7,
        "publication_count": 269,
        "publication_id_list": "10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10066784;10196183;10231017;10411887;10523675;10588656;10618392;10652265;10748026;10771479;10847683;11076937;11145705;11149925;11237011;11350120;11380615;11500511;11590230;11689693;11704860;11790773;11864571;11919634;11956649;11967128;12177196;12376551;12754519;12902340;1464587;14675773;15023524;15033990;15054114;15133129;15169870;15337775;15373777;15542837;15797384;15803139;15814684;16061697;16081809;16212419;16243035;16243036;16286477;16335952;16339170;16382671;16505173;1660188;16639001;16773573;16777452;1691188;1694855;17027967;17060455;17081983;1714783;17158234;17214551;17269730;17322306;17515931;17521629;17559062;17562024;17596512;17698854;17765681;18056264;18191593;18452278;18662984;18669648;18678517;18691976;18697831;18767875;18843291;19139490;19159218;19190773;19194479;19269969;19349973;1935985;19534724;19581409;19635863;19664994;19664995;19690332;19691289;19713215;19863551;19901323;20031617;20068231;20179351;20657595;20667819;20679435;20859650;20940292;21062920;21151158;21378159;21406692;21439340;21621533;21654840;21997417;22189787;22299025;22734669;23090970;23186163;23255595;23481192;23629652;23757206;23870057;2414304;24190977;24220297;24275569;24623723;24659802;24715725;25208567;25208914;25418920;25502872;25505266;25576301;25645385;25802875;25813380;25862245;25892735;25926655;26016997;26375851;26390218;26628301;26918609;26992070;27090790;27338829;27452731;27481945;27713499;27920218;28196833;28218747;28228285;28356423;28467828;28514659;28649982;28832583;28855257;28871256;28904123;29237092;29242379;29317506;29331515;29391424;29393594;29557506;29632046;29741879;29769354;29774024;29786170;29789417;29849084;29910125;30059200;30315122;30391969;30429286;30454721;30573663;30620550;30862836;30885746;31020640;31217245;31389670;31402609;31492838;31611695;31844290;31845994;31871319;32119511;32157095;32350084;32357974;32387766;32488085;32581096;32938616;33214551;33298915;33392160;33537174;33592498;33596089;33691108;33717175;33912179;33917638;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34185709;34357683;34433824;34561969;34742300;34932366;35051231;35154160;35251023;35318648;35513511;35580925;36010968;36215666;36241641;36284347;36309486;37074911;37340703;38375917;38395410;38671389;39226803;39227800;40596516;7476457;7479768;7543090;8143788;8645157;8824274;8939998;8999895;9113980;9252344;9395522;9468612;9565599;9705280;9822605",
        "class_list": "",
        "function": "(Microbial infection) Required for fiber protein-mediated Human Adenovirus 55 and 14a infection; via its interaction with fiber protein., [UniProtKB, PubMed]; A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:17559062, PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Promotes cardiomyocyte cell homeostasis and desmosome junction formation at intercalated disks, as a result plays a role in the maintenance of cardiac conduction and heart chamber integrity (By similarity). Positively regulates pancreatic islet development and maintenance of endothelial cell barrier integrity in the pancreas, therefore involved in the controlled release of insulin from islet cells into the circulation in response to glucose (By similarity). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). Acts as a positive modulator of CSK and EGFR activation via sequestering them away from lipid rafts, this is independent of its role in desmosome cell junctions (PubMed:26918609). Also disrupts the localization of CAV1 to lipid rafts resulting in its distribution throughout the cytoplasm (PubMed:26918609)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Desmoglein 2, expressed earliest among the four isoforms in development, was found to be mutated in arrythmogenic right ventricular cardiomyopathy and is a receptor for a subset of adenoviruses that cause respiratory and urinary tract infections. Review article, [RefSeq, PubMed]; Hyperactivation of ATF4/TGF-beta1 signaling contributes to the progressive cardiac fibrosis in Arrhythmogenic cardiomyopathy caused by DSG2 Variant. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016]., [RefSeq]; Up-regulated DSG2 promotes tumor growth and reduces immune infiltration in cervical cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 3,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 8,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 10,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
        "total_o_glycosites": 10,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 20,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 71,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 86,
        "disease_count": 11,
        "glyco_site_count": 18,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4KKU6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding;GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0030054 cell junction",
        "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:1902459 positive regulation of stem cell population maintenance;GO:0007155 cell adhesion;GO:0043066 negative regulation of apoptotic process;GO:0045785 positive regulation of cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 37.4,
        "record_id": "Q14126-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60610-1",
        "uniprot_id": "DIAP1_HUMAN",
        "mass": 141347.0,
        "length": 1272,
        "protein_name": "Protein diaphanous homolog 1",
        "gene_name": "DIAPH1",
        "organism": "Human",
        "refseq_name": "protein diaphanous homolog 1 isoform 2",
        "refseq_ac": "NP_001073280",
        "gene_names_uniprotkb": "DIAPH1; DIAP1",
        "gene_names_refseq": "DFNA1; DIA1; DIAPH1; DRF1; LFHL1; SCBMS; hDIA1; mDia1",
        "protein_names_uniprotkb": "Protein diaphanous homolog 1; DRF1; Diaphanous-related formin-1",
        "protein_names_refseq": "mammalian diaphanous related formin 1; protein diaphanous homolog 1 isoform 2; protein diaphanous homolog 1",
        "tax_id": 9606,
        "disease": "autosomal dominant nonsyndromic deafness (Disease Ontology:DOID:0050564); autosomal dominant auditory neuropathy 1 (Disease Ontology:DOID:0060690); autosomal dominant nonsyndromic deafness 1 (Disease Ontology:DOID:0110541); sensorineural hearing loss (Disease Ontology:DOID:10003); microcephaly (Disease Ontology:DOID:10907); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); progressive microcephaly-seizures-cortical blindness-developmental delay syndrome (MONDO:MONDO:0014714)",
        "pathway": " (hsa:1729);  (R-HSA-5663220);  (R-HSA-6785631);  (R-HSA-6798695);  (R-HSA-8980692);  (R-HSA-9013026);  (R-HSA-9013106);  (R-HSA-9013405);  (R-HSA-9035034);  (R-HSA-9854909)",
        "pathway_count": 10,
        "publication_count": 319,
        "publication_id_list": "10.1101/2023.09.13.557529;10037681;10232922;10375532;10490598;10523665;10523675;10526156;10559916;10579713;10600384;10619026;10678165;10699171;10873388;10958683;11058585;11085924;11207612;11237011;11373293;11396949;11431473;11432776;11606631;11672528;11680691;11689693;11704860;11784792;11804589;11804590;11884391;11912491;12071859;12093360;12195014;12221077;12221096;12429848;12473120;12531887;12577064;12650940;12732141;12805219;12857875;12877655;14512443;15006353;15023524;15064355;15085137;15107133;15156151;15302923;15342493;15485661;15507212;15601624;15611138;15850391;15864301;15866170;15944396;16112081;16116428;16184169;16217026;16292343;16439214;16467373;16519628;16622419;16622420;16630611;16776779;16777452;16777849;16862148;16887337;16896804;16914516;16917499;16943183;17030981;17064668;17077126;17129783;17198702;1737036;17562871;17702745;17765681;17804252;17916560;17932950;17942708;17976533;18001770;18045866;18097444;18158243;18218625;18452278;18669648;18802007;18829452;18923426;18955552;19350017;19494238;19605563;19608861;19635168;19651622;19673492;19690332;19713215;19815554;20030946;20068231;20101212;20112406;20233848;20400958;20591975;20628200;20660154;20937854;21119010;21148482;21351730;21373644;21397845;21454492;21565175;21576392;21699497;21757538;21834987;21840311;21865595;21868368;21936715;22094460;22096251;22223895;22275430;22298643;22305756;22608513;22665057;22673745;22790947;22911862;22938506;22992742;23087206;23096567;23186163;23200924;23222643;23255595;23301498;23325789;23434736;23481700;23572525;23650620;23801653;23870313;24086303;24102721;24128008;24139804;24259668;24335996;24352656;24715725;24781755;24914801;24933155;25211221;25418920;25425145;25576301;25645385;25668492;25673874;25704760;25746724;25892735;26154972;26371245;26375851;26463574;26529257;26768311;26811146;26887924;26912466;26992070;27145964;27216196;27278019;27452731;27481945;27543614;27808407;27846572;27852748;27986909;28112683;28196833;28486133;28510447;28584191;28832583;28904123;28947137;29146911;29237092;29351928;29493099;29557506;29776664;30429286;30816115;31105010;31217245;31844290;31871319;32119511;32157095;32203420;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33968037;33981976;34087483;34185709;34211107;34357683;34405274;34509645;34725712;34932366;35051231;35132862;35154160;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37543941;37832872;37903764;37938771;38843827;39120629;39534244;40307207;40914422;7479768;7673236;7721814;7737110;7753201;8021274;8537347;8543060;8571126;8617235;8643598;8649427;8662891;8692836;8756646;8769096;8807639;8810315;8816443;8939998;8945468;9013646;9111050;9113980;9305890;9360932;9418861;9490638;9497316;9535835;9548756;9649308;9659915;9670022;9792683;9822605;9829970",
        "class_list": "",
        "function": "Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; An Extended Iranian Family with Autosomal Dominant Non-syndromic Hearing Loss Associated with A Nonsense Mutation in the DIAPH1 Gene. Publication Status: Online-Only, [RefSeq, PubMed]; DIAPH1-Deficiency is Associated with Major T, NK and ILC Defects in Humans. Erratum:[J Clin Immunol. 2024 Nov 16;45(1):43. doi: 10.1007/s10875-024-01832-4. PMID: 39547966] Publication Status: Online-Only, [RefSeq, PubMed]; DIAPH1-MFN2 interaction regulates mitochondria-SR/ER contact and modulates ischemic/hypoxic stress. Publication Status: Online-Only, [RefSeq, PubMed]; Disruption of the productive encounter complex results in dysregulation of DIAPH1 activity., [RefSeq, PubMed]; Mechanisms of actin filament severing and elongation by formins., [RefSeq, PubMed]; This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 8,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NF18;B7ZKW2;E9PEZ2;Q17RN4;Q59FH8;Q9UC76",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0044325 transmembrane transporter binding;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005884 actin filament",
        "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0007605 sensory perception of sound;GO:0030041 actin filament polymerization;GO:0032886 regulation of microtubule-based process",
        "synthesized_glycan_count": 0,
        "hit_score": 32.9,
        "record_id": "O60610-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5TB30-5",
        "uniprot_id": "DEP1A_HUMAN",
        "mass": 92960.0,
        "length": 811,
        "protein_name": "DEP domain-containing protein 1A",
        "gene_name": "DEPDC1",
        "organism": "Human",
        "refseq_name": "DEP domain-containing protein 1A isoform a",
        "refseq_ac": "NP_001107592",
        "gene_names_uniprotkb": "DEPDC1; DEPDC1A",
        "gene_names_refseq": "DEP.8; DEPDC1-V2; DEPDC1A; DEPDC1; SDP35",
        "protein_names_uniprotkb": "DEP domain-containing protein 1A",
        "protein_names_refseq": "DEP domain-containing protein 1A isoform a; DEP domain-containing protein 1A; cell cycle control protein SDP35",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55635)",
        "pathway_count": 1,
        "publication_count": 48,
        "publication_id_list": "17452976;18669648;20587513;23186163;23646139;25064737;25418920;25605201;26992070;27072896;27998971;28393243;28602627;28904123;28919988;29437277;29493099;29557506;29971464;30379171;30791546;31217245;31844290;32157095;32357974;32387766;32500232;32897882;32938616;33298915;33592498;33912179;33936100;33968037;34171305;34405274;34509645;34561969;34932366;35051231;35254053;35580925;36010968;36479633;36768316;36849972;38564630;39068164",
        "class_list": "",
        "function": "Coimmunoprecipitation and immunocytochemistry revealed that DEPDC1 interacted and colocalized with zinc finger transcription factor ZNF224, a known transcriptional repressor., [RefSeq, PubMed]; Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; DEPDC1 as a crucial factor in the progression of human osteosarcoma., [RefSeq, PubMed]; DEPDC1 as a metabolic target regulates glycolysis in renal cell carcinoma through AKT/mTOR/HIF1alpha pathway. Publication Status: Online-Only, [RefSeq, PubMed]; DEPDC1 regulates vincristine-induced cell death by promoting JNK-dependent degradation of the BCL-2 family protein MCL1., [RefSeq, PubMed]; Glycolysis-Related Gene Analyses Indicate That DEPDC1 Promotes the Malignant Progression of Oral Squamous Cell Carcinoma via the WNT/beta-Catenin Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; High DEPDC1 mRNA expression is associated with hepatocellular carcinoma/, [RefSeq, PubMed]; Inhibition of DEPDC1A, a bad prognostic marker in multiple myeloma, delays growth and induces mature plasma cell markers in malignant plasma cells. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8QXE0;A8QXE1;Q05DU3;Q5TB28;Q9H9I3;Q9NX21;Q9NXZ0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005096 GTPase activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0017053 transcription repressor complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0035556 intracellular signal transduction;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q5TB30-5",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UX65-1",
        "uniprot_id": "DRAM2_HUMAN",
        "mass": 29766.0,
        "length": 266,
        "protein_name": "DNA damage-regulated autophagy modulator protein 2",
        "gene_name": "DRAM2",
        "organism": "Human",
        "refseq_name": "DNA damage-regulated autophagy modulator protein 2 isoform a",
        "refseq_ac": "NP_848549",
        "gene_names_uniprotkb": "DRAM2; PRO180; PSEC0031; TMEM77",
        "gene_names_refseq": "CORD21; DRAM2; PRO180; TMEM77; WWFQ154",
        "protein_names_uniprotkb": "DNA damage-regulated autophagy modulator protein 2; Transmembrane protein 77",
        "protein_names_refseq": "DNA damage-regulated autophagy modulator protein 2 isoform a; DNA damage-regulated autophagy modulator protein 2; damage regulated autophagy modulator 2; transmembrane protein 77",
        "tax_id": 9606,
        "disease": "cone-rod dystrophy 21 (Disease Ontology:DOID:0081447)",
        "pathway": " (hsa:128338)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "11237011;12975309;16303743;18669648;19556885;19895784;21584698;25418920;25502872;25576301;25892735;25983245;26509668;26992070;27764573;27846572;27862975;28228285;28832583;28834231;29242379;29317506;29393594;29557506;29632046;29786170;30315122;31020640;31154438;31217245;31394102;31844290;31848261;32079136;32157095;32350084;32983136;33298915;33717175;33912179;33936100;34357683;34932366;35051231;35154160;35251023;35580925;35806404;36010968;36284347;36581221",
        "class_list": "",
        "function": "Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement., [RefSeq, PubMed]; Clinical Course and Electron Microscopic Findings in Lymphocytes of Patients with DRAM2-Associated Retinopathy. Publication Status: Online-Only, [RefSeq, PubMed]; DRAM2 is different from DRAM as it not induced by p53 or p73. DRAM2 is also a lysosomal protein, its overexpression does not modulate autophagy., [RefSeq, PubMed]; Genetic variants on chromosome 1p13.3 near the damage-regulated autophagy modulator 2 gene DRAM2 associated with Non-ST Elevation Myocardial Infarction (rs656843; odds ratio 1.57, P = 3.11 x 10(-10)) in the case-control analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Mycobacterium tuberculosis significantly induces the expression of MIR144*/hsa-miR-144-5p, which targets the 3'-untranslated region of DRAM2., [RefSeq, PubMed]; Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1., [UniProtKB, PubMed, PubMed]; Reduced expression of DRAM2 may contribute to enhanced cell survival in tumor cells., [RefSeq, PubMed]; The Clinical Spectrum and Disease Course of DRAM2 Retinopathy. Publication Status: Online-Only, [RefSeq, PubMed]; The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction., [RefSeq, PubMed]; The protein encoded by this gene binds microtubule-associated protein 1 light chain 3 and is required for autophagy. Defects in this gene are a cause of retinal dystrophy. In addition, two microRNAs (microRNA 125b-1 and microRNA 144) can bind to the mRNA of this gene and produce the disease state. [provided by RefSeq, Mar 2017]., [RefSeq]; Three novel homozygous mutations in the autophagy gene DRAM2 were identified as the molecular cause of disease in the three families: c.518-1G>A, c.628_629insAG and c.693+2T>A., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3SUG9;Q4VWF6;Q86VD3;Q8NBQ4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0010506 regulation of autophagy;GO:0006915 apoptotic process;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:0006914 autophagy",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q6UX65-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96DT5-1",
        "uniprot_id": "DYH11_HUMAN",
        "mass": 520369.0,
        "length": 4516,
        "protein_name": "Dynein axonemal heavy chain 11",
        "gene_name": "DNAH11",
        "organism": "Human",
        "refseq_name": "dynein axonemal heavy chain 11",
        "refseq_ac": "NP_001264044",
        "gene_names_uniprotkb": "DNAH11",
        "gene_names_refseq": "CILD7; DNAH11; DNAHBL; DNAHC11; DNHBL; DPL11",
        "protein_names_uniprotkb": "Dynein axonemal heavy chain 11; Axonemal beta dynein heavy chain 11; Ciliary dynein heavy chain 11",
        "protein_names_refseq": "axonemal beta dynein heavy chain 11; axonemal dynein heavy chain 11; ciliary dynein heavy chain 11; dynein axonemal heavy chain 11; dynein heavy chain 11, axonemal; dynein, axonemal, heavy polypeptide 11; dynein, ciliary, heavy chain 11",
        "tax_id": 9606,
        "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); atrioventricular septal defect (Disease Ontology:DOID:0050651); primary ciliary dyskinesia 7 (Disease Ontology:DOID:0110605)",
        "pathway": " (hsa:8701)",
        "pathway_count": 1,
        "publication_count": 39,
        "publication_id_list": "11237011;12142464;15304525;18022865;22184204;25186273;28467828;28904123;29557506;29741879;30459171;31178125;31844290;32387766;32502341;32938616;32983136;33139725;33141586;33298915;33392160;33592498;33912179;33968037;34078123;34087483;34171305;34405951;34509645;35051231;35580925;36010968;36140829;36178856;36215666;36241641;37088965;37938771;39894887",
        "class_list": "",
        "function": "A Deep Intronic, Pathogenic Variant in DNAH11 Causes Primary Ciliary Dyskinesia., [RefSeq, PubMed]; Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries. Publication Status: Online-Only, [RefSeq, PubMed]; Dynein plays an unexpected role in the regulation of mitochondrial morphology in living cells, by controlling the recruitment of Drp1 to these organelles., [RefSeq, PubMed]; First reports of primary ciliary dyskinesia caused by a shared DNAH11 allele in Canadian Inuit., [RefSeq, PubMed]; Force generating protein required for cilia beating in respiratory epithelia (By similarity). Produces force towards the minus ends of microtubules (By similarity). Key component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required for structural and functional integrity of cilia (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Identification of compound heterozygous DNAH11 variants in a Han-Chinese family with primary ciliary dyskinesia., [RefSeq, PubMed]; Mutations in DNAH11 are a common cause of PCD in patients without ciliary ultrastructural defects; thus, genetic analysis can be used to ascertain the diagnosis of PCD in this challenging group of patients., [RefSeq, PubMed]; Mutations in the DNAH11 gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia, [RefSeq, PubMed]; This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 134,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 13,
        "disease_count": 4,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UJ82",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding",
        "go_cellular_component": "GO:0005874 microtubule;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0030286 dynein complex;GO:0097729 9+2 motile cilium",
        "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0030317 flagellated sperm motility;GO:0007368 determination of left/right symmetry;GO:0003356 regulation of cilium beat frequency;GO:0120229 protein localization to motile cilium",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q96DT5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75907-1",
        "uniprot_id": "DGAT1_HUMAN",
        "mass": 55278.0,
        "length": 488,
        "protein_name": "Diacylglycerol O-acyltransferase 1",
        "gene_name": "DGAT1",
        "organism": "Human",
        "refseq_name": "diacylglycerol O-acyltransferase 1",
        "refseq_ac": "NP_036211",
        "gene_names_uniprotkb": "DGAT1; AGRP1; DGAT",
        "gene_names_refseq": "ARAT; ARGP1; DGAT1; DGAT; DIAR7",
        "protein_names_uniprotkb": "Diacylglycerol O-acyltransferase 1; 2.3.1.20; 2.3.1.76; ACAT-related gene product 1; ARAT; Acyl-CoA retinol O-fatty-acyltransferase; Diglyceride acyltransferase; Retinol O-fatty-acyltransferase",
        "protein_names_refseq": "ACAT related gene product 1; acyl coenzyme A:cholesterol acyltransferase related gene 1; acyl-CoA retinol O-fatty-acyltransferase; acyl-CoA:diacylglycerol acyltransferase; diacylglycerol O-acyltransferase 1; diglyceride acyltransferase",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); cardiomyopathy (Disease Ontology:DOID:0050700); congenital diarrhea 7 with exudative enteropathy (Disease Ontology:DOID:0060778); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); dopamine beta-hydroxylase deficiency (Disease Ontology:DOID:0090145); nephrotic syndrome (Disease Ontology:DOID:1184); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); high grade glioma (Disease Ontology:DOID:3070); ureteral obstruction (Disease Ontology:DOID:5199); rheumatoid arthritis (Disease Ontology:DOID:7148); chronic kidney disease (Disease Ontology:DOID:784); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:8694);  (R-HSA-1482883);  (R-HSA-6798695);  (R-HSA-75109)",
        "pathway_count": 4,
        "publication_count": 82,
        "publication_id_list": "11237011;11481335;11672446;12618427;12824082;14521909;14970677;15272052;15364929;15671038;15845384;16106050;16214399;17158099;18238778;18452279;18694939;18718904;18768481;19336658;19957260;19962385;20034933;20166139;20643956;21068004;23114594;23650620;24275569;25418920;25576301;25645385;25838202;26992070;27862975;28218747;28228285;28420705;28514659;28832583;28904123;29393594;29437277;29557506;29632046;30237576;30315122;30429286;30484775;30524438;30779550;30833945;31154438;31217245;31844290;31848261;32157095;32387766;32433610;32433611;32488085;32938616;32983136;33298915;33912179;33968037;33981976;34171305;34509645;35051231;35251023;35494241;35580925;36010968;36241641;36284347;37779421;37820117;37973951;38500157;8692836;9756920",
        "class_list": "",
        "function": "Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:16214399, PubMed:18768481, PubMed:28420705, PubMed:32433610, PubMed:32433611, PubMed:9756920). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (PubMed:18768481). In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed:16214399). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (PubMed:18768481). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:16214399). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Lipid droplets in Zika neuroinfection: Potential targets for intervention? Review article Publication Status: Online-Only, [RefSeq, PubMed]; Targeting DGAT1 inhibits prostate cancer cells growth by inducing autophagy flux blockage via oxidative stress., [RefSeq, PubMed]; The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background., [RefSeq, PubMed]; This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 27,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 14,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RWQ2;D3DWL6;Q96BB8",
        "ec_number_list": "3.4.24.81;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;2.3.1.51;1.14.19.17;5.2.1.-;2.3.1.20;2.3.1.76;2.7.11.1;3.4.21.73;1.6.3.-;3.1.3.48;1.14.14.18;3.1.1.13;3.1.1.4;3.1.1.3;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;3.6.5.2;3.4.24.-;7.6.2.1;3.1.1.23;3.1.1.79;3.2.2.6;1.1.1.-;3.1.4.4;2.3.1.22;2.3.1.75;2.3.2.27;2.3.1.78;2.3.1.-",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0004144 diacylglycerol O-acyltransferase activity;GO:0016746 acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity;GO:0050252 retinol O-fatty-acyltransferase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0035579 specific granule membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0006641 triglyceride metabolic process;GO:0034379 very-low-density lipoprotein particle assembly;GO:0055089 fatty acid homeostasis;GO:0035336 long-chain fatty-acyl-CoA metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 8.3,
        "record_id": "O75907-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NEG7-1",
        "uniprot_id": "DEN6B_HUMAN",
        "mass": 66464.0,
        "length": 585,
        "protein_name": "Protein DENND6B",
        "gene_name": "DENND6B",
        "organism": "Human",
        "refseq_name": "protein DENND6B",
        "refseq_ac": "NP_001001794",
        "gene_names_uniprotkb": "DENND6B; FAM116B",
        "gene_names_refseq": "AFI1B; DENND6B; FAM116B",
        "protein_names_uniprotkb": "Protein DENND6B; DENN domain-containing protein 6B",
        "protein_names_refseq": "DENN domain-containing protein 6B; DENN/MADD domain containing 6B; family with sequence similarity 116, member B; protein DENND6B; protein FAM116B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:414918);  (R-HSA-8876198)",
        "pathway_count": 2,
        "publication_count": 207,
        "publication_id_list": "10818110;10990452;11038176;11179213;11237011;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18354496;18367545;1845915;18477386;18477474;18559336;18585354;18664496;18701652;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19620288;19656848;19725050;19729655;19745841;20008558;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23645161;23678941;23684622;23713133;23839779;24296415;24366607;24644286;24694596;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25469497;25472813;25648148;25713415;25880248;25925668;26055712;26154972;26177209;26245486;26434594;26538022;26925400;26936971;26992070;27041585;27044746;27103185;27246931;27329675;27846572;28832583;29242379;29493099;29557506;30315122;30524438;31373491;31844290;32157095;32357974;32502341;32897882;33298915;33912179;34932366;35051231;36010968;39894887;7688123;7911226;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6X8I5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0055037 recycling endosome",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 21.2,
        "record_id": "Q8NEG7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P37059-1",
        "uniprot_id": "DHB2_HUMAN",
        "mass": 42785.0,
        "length": 387,
        "protein_name": "17-beta-hydroxysteroid dehydrogenase type 2",
        "gene_name": "HSD17B2",
        "organism": "Human",
        "refseq_name": "17-beta-hydroxysteroid dehydrogenase type 2",
        "refseq_ac": "NP_002144",
        "gene_names_uniprotkb": "HSD17B2; EDH17B2; SDR9C2",
        "gene_names_refseq": "EDH17B2; HSD17B2; HSD17; SDR9C2",
        "protein_names_uniprotkb": "17-beta-hydroxysteroid dehydrogenase type 2; 1.1.1.239; 1.1.1.62; 17-beta-HSD 2; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Estradiol 17-beta-dehydrogenase 2; Microsomal 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C member 2; Testosterone 17-beta-dehydrogenase",
        "protein_names_refseq": "17-beta-HSD 2; 17-beta-hydroxysteroid dehydrogenase type 2; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; estradiol 17-beta-dehydrogenase 2; microsomal 17-beta-hydroxysteroid dehydrogenase; short chain dehydrogenase/reductase family 9C member 2; testosterone 17-beta-dehydrogenase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3294);  (R-HSA-193144)",
        "pathway_count": 2,
        "publication_count": 34,
        "publication_id_list": "10385431;11237011;11895893;11940569;12404296;12697717;16332571;17067289;17081983;1825337;19027824;2149502;2171939;22792371;25577493;26230928;29557506;29789417;30228209;30779550;31154438;32938616;33246154;34185709;35051231;35510872;35580925;36010968;37244445;7336466;7546291;8076586;8099587;9783542",
        "class_list": "",
        "function": "A long non-coding RNA as a direct vitamin D target transcribed from the antisense strand of the human HSD17B2 locus., [RefSeq, PubMed]; Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity., [UniProtKB, PubMed, PubMed, PubMed]; Homology modeling meets site-directed mutagenesis: An ideal combination to elucidate the topology of 17beta-HSD2., [RefSeq, PubMed]; Our findings provide evidence of the clinical relevance, significance, and regulation of HSD17B2 in prostate cancer progression, which might provide new strategies for clinical management by targeting the functional silencing mechanisms of HSD17B2., [RefSeq, PubMed]; Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7T4",
        "ec_number_list": "1.1.1.62;1.1.1.239;1.1.1.105;1.1.1.209;1.1.1.53;1.1.1.51;1.1.1.-;1.1.1.225;1.1.1.357;1.1.1.210;1.1.1.188;1.1.1.64;1.1.1.112;1.3.1.20;1.1.1.270;1.1.1.149;1.1.1.330;1.1.1.n12;1.1.1.35;1.1.1.178;1.1.1.159",
        "go_molecular_function": "GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity;GO:0047035 testosterone dehydrogenase (NAD+) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0032526 response to retinoic acid;GO:0006703 estrogen biosynthetic process;GO:0008209 androgen metabolic process;GO:0008202 steroid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "P37059-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H6R0-1",
        "uniprot_id": "DHX33_HUMAN",
        "mass": 78874.0,
        "length": 707,
        "protein_name": "ATP-dependent RNA helicase DHX33",
        "gene_name": "DHX33",
        "organism": "Human",
        "refseq_name": "ATP-dependent RNA helicase DHX33 isoform 2",
        "refseq_ac": "NP_001186628",
        "gene_names_uniprotkb": "DHX33; DDX33",
        "gene_names_refseq": "DDX33; DHX33",
        "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX33; 3.6.4.13; DEAH box protein 33",
        "protein_names_refseq": "ATP-dependent RNA helicase DHX33 isoform 2; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 33; DEAH (Asp-Glu-Ala-His) box polypeptide 33; DEAH box protein 33; putative ATP-dependent RNA helicase DHX33",
        "tax_id": 9606,
        "disease": "obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:56919)",
        "pathway_count": 1,
        "publication_count": 70,
        "publication_id_list": "11237011;19423540;20068231;20406964;21930779;23481700;23871209;24715725;25418920;25505266;25576301;25645385;25880248;26100019;26154972;26375851;26758079;26811146;26992070;27600516;27846572;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29632046;29769354;30315122;30418433;30484775;30524438;30779550;31154438;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33592498;33912179;33968037;33981976;34087483;34171305;34405274;34509645;35051231;35561310;35580925;36010968;36215666;36241641;36403931;37115050;37256545;37543097",
        "class_list": "",
        "function": "Comprehensive analysis of immune implication and prognostic value of DHX33 in sarcoma., [RefSeq, PubMed]; GSK-3beta phosphorylation of DHX33 leads to its ubiquitination mediated protein degradation., [RefSeq, PubMed]; Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779, PubMed:23871209, PubMed:26100019). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (PubMed:23871209). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (PubMed:23871209). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; RNA helicase DHX33 regulates HMGB family genes in human cancer cells., [RefSeq, PubMed]; Systematic analysis of the prognostic and immunological role of DHX33 in pan-cancer., [RefSeq, PubMed]; This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]., [RefSeq]; We show the mechanistic importance of DHX33 in rRNA transcription and proliferation, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DHF9;Q4G149;Q5CZ73;Q9H5M9",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003725 double-stranded RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0072559 NLRP3 inflammasome complex",
        "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0006413 translational initiation;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0032481 positive regulation of type I interferon production;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q9H6R0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O94769-1",
        "uniprot_id": "ECM2_HUMAN",
        "mass": 79789.0,
        "length": 699,
        "protein_name": "Extracellular matrix protein 2",
        "gene_name": "ECM2",
        "organism": "Human",
        "refseq_name": "extracellular matrix protein 2 isoform 2 precursor",
        "refseq_ac": "NP_001184224",
        "gene_names_uniprotkb": "ECM2",
        "gene_names_refseq": "ECM2",
        "protein_names_uniprotkb": "Extracellular matrix protein 2; Matrix glycoprotein SC1/ECM2",
        "protein_names_refseq": "extracellular matrix protein 2 isoform 2 precursor; extracellular matrix protein 2, female organ and adipocyte specific; matrix glycoprotein SC1/ECM2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1842)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;18702456;20187088;24190977;29741879;30429286;30459171;32938616;35051231;36284347;37074911;37938771;9790758",
        "class_list": "",
        "function": "ECM2 encodes extracellular matrix protein 2, so named because it shares extensive similarity with known extracelluar matrix proteins. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]., [RefSeq]; Promotes matrix assembly and cell adhesiveness., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 8836,
        "biomarker_type": "",
        "glycan_count": 21,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R730;E2PU11;Q5T9F2;Q7Z3D0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0070052 collagen V binding",
        "go_cellular_component": "GO:0031012 extracellular matrix;GO:0140150 gel phase of interstitial matrix",
        "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0007160 cell-matrix adhesion;GO:0010811 positive regulation of cell-substrate adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "O94769-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16254-1",
        "uniprot_id": "E2F4_HUMAN",
        "mass": 43960.0,
        "length": 413,
        "protein_name": "Transcription factor E2F4",
        "gene_name": "E2F4",
        "organism": "Human",
        "refseq_name": "transcription factor E2F4",
        "refseq_ac": "NP_001941",
        "gene_names_uniprotkb": "E2F4",
        "gene_names_refseq": "E2F-4; E2F4",
        "protein_names_uniprotkb": "Transcription factor E2F4; E2F-4",
        "protein_names_refseq": "E2F transcription factor 4, p107/p130-binding; p107/p130-binding protein; transcription factor E2F4",
        "tax_id": 9606,
        "disease": "otitis media (Disease Ontology:DOID:10754); Lynch syndrome (Disease Ontology:DOID:3883)",
        "pathway": " (hsa:1874);  (R-HSA-1362277);  (R-HSA-1362300);  (R-HSA-1538133);  (R-HSA-2173796);  (R-HSA-6804114);  (R-HSA-69202);  (R-HSA-69205);  (R-HSA-69231);  (R-HSA-69656)",
        "pathway_count": 10,
        "publication_count": 215,
        "publication_id_list": "10022869;10090723;10199400;10207050;10228158;10323868;10375532;10385618;10454565;10454584;10499802;10524633;10597240;10679953;10692433;10797289;10831586;11007770;11013220;11032757;11073976;11157749;11231573;11231585;11237011;11274402;11416152;11418595;11424093;11427533;11574543;11585773;11719808;11884610;11907280;11959842;11988738;12150994;12435635;12444543;12446674;12730199;12782299;12917425;1312467;1396589;1423597;14517297;14532282;14597415;14657019;14990995;15014447;15100235;15107404;15150273;15186775;15510213;15574328;15579463;16195327;16278212;16319104;16360038;16582612;16772293;16782892;17092340;17172876;17254966;17254967;17438144;17531812;17671431;17719541;17908796;1828392;1828393;1828394;18414028;18568018;18710949;18827403;19054851;19075005;19458076;19487459;19914168;20107323;20460379;20595680;20663872;20843055;20952511;21423214;21498570;21715330;22002537;22275377;23007395;23301498;23481700;23485469;23622515;23737759;23919615;24096481;24275569;24366607;24515438;24714562;24715725;24876129;25418920;25733683;25880248;26154972;26728094;26992070;27600516;27846572;27920218;28832583;28834231;28904123;29242379;29393594;29557506;29632046;29786170;29995440;30315122;30429286;30524438;30711375;30833945;31154438;31217245;31530632;31543423;31844290;31848261;31936902;32157095;32265295;32357974;32387766;32502341;32897882;32938616;33141586;33298915;33592498;33633747;33912179;33936100;33968037;33981976;34171305;34357683;34509645;35051231;35251023;35561310;35580925;35840663;36010968;36241641;36567912;37349788;37567906;39531497;39894887;7623816;7629134;7743995;7784094;7797074;7799941;7892279;7929342;7954814;7958924;7958925;7973727;8050359;8114698;8114739;8139570;8246996;8288595;8336704;8497257;8618861;8700224;8943353;9020173;9042862;9074408;9106657;9144196;9190208;9199292;9325318;9447971;9448290;9482921;9508775;9520412;9632134;9659898;9662327;9724731;9778043;9891042",
        "class_list": "",
        "function": "E2F4 transcription factor is a prognostic biomarker related to immune infiltration of head and neck squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics. Publication Status: Online-Only, [RefSeq, PubMed]; High Expression of E2F4 Is an Adverse Prognostic Factor and Related to Immune Infiltration in Oral Squamous Cell Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the  tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis., [UniProtKB, PubMed, UniProtKB, PubMed]; Transcriptional induction of NF-kappaB-inducing kinase by E2F4/5 facilitates collective invasion of GBM cells. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NGR8;B5BU56;Q12991;Q15328",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:1903251 multi-ciliated epithelial cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 21.9,
        "record_id": "Q16254-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96SB4-2",
        "uniprot_id": "SRPK1_HUMAN",
        "mass": 74325.0,
        "length": 655,
        "protein_name": "SRSF protein kinase 1",
        "gene_name": "SRPK1",
        "organism": "Human",
        "refseq_name": "SRSF protein kinase 1",
        "refseq_ac": "NP_003128",
        "gene_names_uniprotkb": "SRPK1",
        "gene_names_refseq": "SFRSK1; SRPK1",
        "protein_names_uniprotkb": "SRSF protein kinase 1; 2.7.11.1; SFRS protein kinase 1; SR-protein-specific kinase 1; Serine/arginine-rich protein-specific kinase 1",
        "protein_names_refseq": "SFRS protein kinase 1; SR-protein-specific kinase 1; SRSF protein kinase 1; serine/arginine-rich splicing factor kinase 1; serine/threonine-protein kinase SRPK1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6732);  (R-HSA-9694631);  (R-HSA-9821993)",
        "pathway_count": 3,
        "publication_count": 129,
        "publication_id_list": "10049757;10390541;11509566;12134018;12565829;14555757;15034300;15848177;16122776;16209947;17081983;17223538;17697703;18155240;18342604;18452278;18669648;18687337;18691976;18767875;19240134;19413330;19415658;19477182;19553338;19651622;19674106;19690332;19886675;20068231;20708644;21157427;21205200;21205204;22362753;22564745;22727668;23186163;23301498;24275569;24366607;24715725;25576301;25810538;25880248;26154972;26375851;26598975;26992070;27600516;27846572;27920218;28063628;28076779;28218747;28228285;28514659;28832583;28834231;28904123;29199039;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29786170;30315122;30410026;30524438;30745339;30779550;30833945;31154438;31217245;31530632;31844290;31848261;32029454;32157095;32161166;32350084;32357974;32387766;32461560;32488085;32502341;32637943;32645325;32723359;32817937;32877642;32897882;32938616;32983136;33123756;33248025;33537174;33592498;33633747;33691108;33717175;33808326;33912179;33968037;33997890;34019948;34029587;34087483;34561969;34932366;35051231;35251023;35318648;35561310;35580925;36010968;36226860;36241641;36284347;36303126;36869126;38376036;40914422;8208298;9237760",
        "class_list": "",
        "function": "Inhibition of SRPK1, a key splicing regulator, exhibits antitumor and chemotherapeutic-sensitizing effects on extranodal NK/T-cell lymphoma cells. Publication Status: Online-Only, [RefSeq, PubMed]; SRPK1 promotes sepsis-induced acute lung injury via regulating PI3K/AKT/FOXO3 signaling., [RefSeq, PubMed]; Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI resistance by enhancing GSK3beta Ser9 autophosphorylation independent of its kinase activity in non-small-cell lung cancer., [RefSeq, PubMed]; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. Phosphorylates the N-terminus of ERC1 (PubMed:30745339)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Spatiotemporal expression and coexpression patterns of SRPK1 in the human brain: A neurodevelopmental perspective., [RefSeq, PubMed]; This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DS61;Q12890;Q5R364;Q5R365;Q8IY12",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007059 chromosome segregation;GO:0035556 intracellular signal transduction;GO:0045087 innate immune response;GO:0045071 negative regulation of viral genome replication",
        "synthesized_glycan_count": 0,
        "hit_score": 13.2,
        "record_id": "Q96SB4-2",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WYQ5-1",
        "uniprot_id": "DGCR8_HUMAN",
        "mass": 86045.0,
        "length": 773,
        "protein_name": "Microprocessor complex subunit DGCR8",
        "gene_name": "DGCR8",
        "organism": "Human",
        "refseq_name": "microprocessor complex subunit DGCR8 isoform 2",
        "refseq_ac": "NP_001177255",
        "gene_names_uniprotkb": "DGCR8; C22orf12; DGCRK6; LP4941",
        "gene_names_refseq": "C22orf12; DGCR8; DGCRK6; Gy1; pasha",
        "protein_names_uniprotkb": "Microprocessor complex subunit DGCR8; DiGeorge syndrome critical region 8",
        "protein_names_refseq": "DiGeorge syndrome critical region 8; DiGeorge syndrome critical region gene 8; microprocessor complex subunit DGCR8 isoform 2; microprocessor complex subunit DGCR8",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413)",
        "pathway": " (hsa:54487);  (R-HSA-203927);  (R-HSA-8986944)",
        "pathway_count": 3,
        "publication_count": 127,
        "publication_id_list": "11201747;11237011;11452083;12411504;12411505;12705904;14508493;14631048;14681208;14730017;15284456;15364901;15372072;15498874;15525708;15531877;15574589;15589161;15973356;16142218;16271386;16357216;16424907;16751099;16906129;16963499;17057362;17081983;17099701;17159994;17452327;17531811;17704815;17765891;17932509;18178619;18220336;18452278;18477386;18669648;18728384;18782830;18842624;19135890;19401777;19413330;19651622;19690332;19966796;20068231;21406692;21726814;22106413;22118463;22163034;22844086;23063121;23063653;23186163;23251028;23301498;23481700;23511973;23531496;23624860;23661684;24275569;25218447;25326327;25418920;25568082;25755297;25793518;25799998;25880248;26027739;26126715;26202964;26748718;26811146;26843422;26992070;27846572;27893789;27920218;28063628;28218747;28380355;28683304;28832583;29242379;29393594;29437277;29493099;29557506;29632046;29786170;29789417;30315122;30429286;30484775;30833945;31530632;31819270;31844290;31848261;32157095;32357974;32387766;32897882;32938616;33298915;33592498;33633747;33717175;33912179;33968037;33981976;34188037;35051231;35580925;36215666;36241641;36360162;36811004;36950067;38252873",
        "class_list": "",
        "function": "Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; DGCR8 is required for the maturation of miRNA primary transcripts., [RefSeq, PubMed]; DGCR8 may be an essential component of the primary miRNA processing complex, along with Drosha., [RefSeq, PubMed]; Molecular cloning and expression analysis of DGCR8, [RefSeq, PubMed]; Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene. Publication Status: Online-Only, [RefSeq, PubMed]; Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules., [RefSeq, PubMed]; Splice site m[6]A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]., [RefSeq]; Thus, DGCR8 may function as the molecular anchor that measures the distance from the dsRNA-ssRNA junction, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8G1;Q6DCB2;Q6MZE9;Q6Y2L0;Q96G39;Q96GP8;Q9H6L8;Q9H6T7;Q9NRW2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006974 DNA damage response;GO:0031053 primary miRNA processing;GO:2000633 positive regulation of pre-miRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 13.0,
        "record_id": "Q8WYQ5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P62508-1",
        "uniprot_id": "ERR3_HUMAN",
        "mass": 51306.0,
        "length": 458,
        "protein_name": "Estrogen-related receptor gamma",
        "gene_name": "ESRRG",
        "organism": "Human",
        "refseq_name": "estrogen-related receptor gamma isoform 2",
        "refseq_ac": "NP_001127757",
        "gene_names_uniprotkb": "ESRRG; ERR3; ERRG2; KIAA0832; NR3B3",
        "gene_names_refseq": "ERR-gamma; ERR3; ERRgamma; ERRg; ESRRG; NR3B3",
        "protein_names_uniprotkb": "Estrogen-related receptor gamma; ERR gamma-2; Estrogen receptor-related protein 3; Nuclear receptor subfamily 3 group B member 3",
        "protein_names_refseq": "ERR gamma-2; estrogen receptor-related protein 3; estrogen-related receptor gamma isoform 2; nuclear receptor subfamily 3 group B member 3",
        "tax_id": 9606,
        "disease": "azoospermia (Disease Ontology:DOID:14227); cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:2104);  (R-HSA-383280)",
        "pathway_count": 2,
        "publication_count": 31,
        "publication_id_list": "10072763;10235266;10428842;10542397;10707956;11237011;11864604;11865025;14651967;15175151;15896744;16307879;16371476;16751179;16990259;18063693;19067653;20484414;23836911;28855257;29557506;30078552;31844290;32157095;33592498;35051231;38479224;38733994;39231208;9653119;9676434",
        "class_list": "",
        "function": "ERRalpha and ERRgamma coordinate expression of genes associated with Alzheimer's disease, inhibiting DKK1 to suppress tau phosphorylation., [RefSeq, PubMed]; ERRgamma-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress., [RefSeq, PubMed]; Metabolic regulator ERRgamma governs gastric stem cell differentiation into acid-secreting parietal cells., [RefSeq, PubMed]; Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]., [RefSeq]; Transcriptional activation by ERR3 can be ligand-independent., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4I0;A8K6I2;B3KY84;E9PGB7;F8W8J3;O75454;O96021;Q68DA0;Q6P274;Q6PK28;Q6TS38;Q9R1F3;Q9UNJ4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003707 nuclear steroid receptor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0048384 retinoic acid receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "P62508-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P41219-1",
        "uniprot_id": "PERI_HUMAN",
        "mass": 53651.0,
        "length": 470,
        "protein_name": "Peripherin",
        "gene_name": "PRPH",
        "organism": "Human",
        "refseq_name": "peripherin",
        "refseq_ac": "NP_006253",
        "gene_names_uniprotkb": "PRPH; NEF4; PRPH1",
        "gene_names_refseq": "NEF4; PRPH1; PRPH",
        "protein_names_uniprotkb": "Peripherin; Neurofilament 4",
        "protein_names_refseq": "neurofilament 4 (57kD); peripherin",
        "tax_id": 9606,
        "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)",
        "pathway": " (hsa:5630)",
        "pathway_count": 1,
        "publication_count": 37,
        "publication_id_list": "11237011;15322088;15446584;17569669;18408015;20363051;21088854;23179371;23646949;26154972;29351928;29437277;29557506;30078552;30992453;31154438;31530632;31844290;32157095;32897882;32938616;32983136;33537174;33968037;33981976;34171305;34509645;34932366;35051231;35318648;35580925;36010968;36241641;37217939;37938771;7806235;9453548",
        "class_list": "",
        "function": "Class-III neuronal intermediate filament protein (By similarity). May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (PubMed:15322088, PubMed:15446584). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (By similarity). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Genome-wide association study of sural nerve conduction amplitude and velocity in 7045 Icelanders and find a low-frequency splice-donor variant in PRPH associated with reduced amplitude of the sural nerve action potential, but not with sural nerve conduction velocity. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N577",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043204 perikaryon;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0045109 intermediate filament organization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "P41219-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P55265-1",
        "uniprot_id": "DSRAD_HUMAN",
        "mass": 136066.0,
        "length": 1226,
        "protein_name": "Double-stranded RNA-specific adenosine deaminase",
        "gene_name": "ADAR",
        "organism": "Human",
        "refseq_name": "double-stranded RNA-specific adenosine deaminase isoform d",
        "refseq_ac": "NP_001020278",
        "gene_names_uniprotkb": "ADAR; ADAR1; DSRAD; G1P1; IFI4",
        "gene_names_refseq": "ADAR1; ADAR; AGS6; DRADA; DSH; DSRAD; G1P1; IFI-4; IFI4; K88DSRBP; P136",
        "protein_names_uniprotkb": "Double-stranded RNA-specific adenosine deaminase; 136 kDa double-stranded RNA-binding protein; 3.5.4.37; DRADA; IFI-4; Interferon-inducible protein 4; K88DSRBP; p136",
        "protein_names_refseq": "136 kDa double-stranded RNA-binding protein; adenosine deaminase acting on RNA 1-A; double-stranded RNA-specific adenosine deaminase isoform d; dsRNA adenosine deaminase; dsRNA adeonosine deaminase; interferon-induced protein 4; interferon-inducible protein 4",
        "tax_id": 9606,
        "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629); dyschromatosis symmetrica hereditaria (Disease Ontology:DOID:0060257); stomach cancer (Disease Ontology:DOID:10534); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); liver cirrhosis (Disease Ontology:DOID:5082)",
        "pathway": " (hsa:103);  (R-HSA-75102);  (R-HSA-77042);  (R-HSA-909733);  (R-HSA-9833482)",
        "pathway_count": 5,
        "publication_count": 366,
        "publication_id_list": "10082513;10200312;10348343;10364558;10395669;10400669;10535945;10542297;10620360;10626894;10648614;10848580;10866685;10982844;11092454;11096080;11134010;11152499;11156368;11237011;11238103;11238927;11278865;11313968;11337497;11337501;11350938;11377645;11404376;11438540;11500375;11585831;11781817;11909525;11939789;11985496;12029096;12231563;12397061;12618436;12665561;12766484;12840004;12842042;12882984;12916015;1373135;14585331;14769151;15047845;15146470;15229216;15299030;15312780;15449939;15556947;15659327;15737233;15752359;15778442;15858013;15907845;16009940;16055709;16120648;16171819;16179258;16179259;16237447;16373505;16431927;16475990;16600570;16717090;1695551;16959974;16964243;16982605;16987978;17079286;17081983;17196820;17251292;1730654;17351669;17478391;17924679;17969444;18035202;18096616;18178553;18220336;18362360;18452278;18575461;18669648;18691976;18767875;18835251;18957415;18991276;19124606;19229320;19413330;19416861;19605474;19651874;19664995;19690332;19710021;19733181;19804757;19838063;19908260;20058876;20068231;20130243;20192758;20363976;20395957;20519500;20643137;20685959;21072047;21123651;21182352;21211811;21289159;21294215;21406692;21490091;21518807;21636578;21769729;21937648;21978664;21994559;22022963;22113393;2211721;22214662;22278222;22424782;2247437;22645359;22986343;22988838;23001123;23061660;23084476;23121362;23186163;23229543;23301498;23481700;23732991;24129315;24347309;24366607;24417533;24623135;24659800;24714562;24715725;24753571;25114211;25371710;25576301;25653431;25755297;25810538;25848059;25880248;26024233;26154972;26432638;26446704;26488609;26716879;26811146;26817845;26992070;27208315;27269119;27397612;27423063;27503676;27543614;27600516;27655845;27846572;27862975;27920218;27974558;28063628;28069888;28132026;28167698;28218747;28228285;28281686;28446606;28510447;28514659;28657654;28765891;28832583;28834231;28904123;29170442;29175459;29231267;29242379;29331515;29348664;29351928;29393594;29394925;29395325;29437277;29440070;29493099;29501855;29508533;29557506;29632046;29632711;29769354;29786170;30001391;30059200;30174290;30315122;30379171;30410026;30429286;30444036;30485383;30770398;31031002;31217245;31492838;31844290;32032529;32093270;32113509;32119511;32157095;32350084;32357974;32387766;32488085;32502341;32511913;32574038;32574262;32661006;32716602;32758689;32801355;32862111;32870666;32897882;32938616;32983136;33117408;33123756;33141586;33189161;33193462;33214551;33298915;33392160;33396578;33465208;33592498;33633747;33691108;33717175;33808629;33911136;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34174402;34211107;34229054;34357683;34405274;34509645;34561969;34725712;34932366;34974812;35051231;35083852;35132862;35254053;35289036;35318648;35459560;35513511;35580925;35685460;35947956;36010968;36241641;36284347;36581221;36712380;37127961;37340703;37938771;38665916;39531497;39534244;40307207;40596516;40914422;6162102;6548414;688397;7491766;7510216;7515177;7526154;7537377;7540766;7545299;7565688;7693978;7737357;7903669;7972084;8197134;8232552;8576172;8576179;8605876;8621447;8661426;8702790;8810342;8910500;9020165;9034343;9079663;9096384;9121453;9149227;9242679;9334213;9442054;9521856;9528799;9660177;9687506;9737981;9819388;9847332;9861020;9920933",
        "class_list": "",
        "function": "ADAR1 and its implications in cancer development and treatment. Review article, [RefSeq, PubMed]; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 14,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 14,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 14,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 14,
        "reported_glycation": 0,
        "reported_snv": 46,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 6,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AQQ9;B1AQR0;D3DV76;O15223;O43859;O43860;Q9BYM3;Q9BYM4",
        "ec_number_list": "2.7.7.84;3.6.4.10;2.7.10.2;2.7.11.1;3.4.25.1;3.6.5.-;3.5.4.37;3.1.26.-;3.6.4.13;4.2.-.-;3.1.13.1;2.3.2.27;1.3.1.91;2.7.1.91;2.3.1.-;2.7.-.-;2.7.4.-;3.1.5.-",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0070922 RISC complex assembly;GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0016556 mRNA modification;GO:0045087 innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 38.3,
        "record_id": "P55265-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UBX2-1",
        "uniprot_id": "DUX4_HUMAN",
        "mass": 44940.0,
        "length": 424,
        "protein_name": "Double homeobox protein 4",
        "gene_name": "DUX4",
        "organism": "Human",
        "refseq_name": "double homeobox protein 4 isoform DUX4-fl",
        "refseq_ac": "NP_001280727",
        "gene_names_uniprotkb": "DUX4; DUX10",
        "gene_names_refseq": "DUX4L; DUX4",
        "protein_names_uniprotkb": "Double homeobox protein 4; Double homeobox protein 10",
        "protein_names_refseq": "double homeobox protein 10; double homeobox protein 4 isoform DUX4-fl; double homeobox protein 4/10",
        "tax_id": 9606,
        "disease": "facioscapulohumeral muscular dystrophy 1 (Disease Ontology:DOID:0111192)",
        "pathway": " (hsa:100288687);  (R-HSA-9819196)",
        "pathway_count": 2,
        "publication_count": 32,
        "publication_id_list": "10433963;15709750;17984056;19320656;21060811;22209328;23934149;24145033;24278031;26360614;26816005;26951377;27062923;27378237;28459454;28459456;28459457;28935672;29572508;29618456;30054554;30315230;30322619;30540931;31630170;33912179;34267371;35051231;35402882;36074823;36158201;39488616",
        "class_list": "",
        "function": "Probably inactive as a transcriptional activator, due to the absence of the C-terminal region that is important for transcriptional activation. Can inhibit transcriptional activation mediated by isoform 1. Heterologous expression of isoform 2 has no deleterious effect on cell survival., [UniProtKB, PubMed]; Temporal variation in p38-mediated regulation of DUX4 in facioscapulohumeral muscular dystrophy. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]; Transcription factor that is selectively and transiently expressed in cleavage-stage embryos (PubMed:28459457). Binds to double-stranded DNA elements with the consensus sequence 5'-TAATCTAATCA-3' (PubMed:28459454, PubMed:28459457, PubMed:29572508, PubMed:30315230, PubMed:30540931). Binds to chromatin containing histone H3 acetylated at 'Lys-27' (H3K27ac) and promotes deacetylation of H3K27ac. In parallel, binds to chromatin that lacks histone H3 acetylation at 'Lys-27' (H3K27ac) and recruits EP300 and CREBBP to promote acetylation of histone H3 at 'Lys-27' at new sites (PubMed:26951377). Involved in transcriptional regulation of numerous genes, primarily as transcriptional activator, but also mediates repression of a set of target genes (PubMed:17984056, PubMed:26951377, PubMed:27378237, PubMed:28459454, PubMed:28459457, PubMed:29572508, PubMed:29618456, PubMed:30540931). Promotes expression of ZSCAN4 and KDM4E, two proteins with essential roles during early embryogenesis (PubMed:26951377, PubMed:27378237, PubMed:28459457, PubMed:29618456). Promotes nuclear translocation of CTNNB1/beta-catenin and its subsequent activation of target genes (PubMed:36158201). Heterologous expression in cultured embryonic stem cells mediates transcription of HERVL retrotransposons and transcripts derived from ACRO1 and HSATII satellite repeats (PubMed:28459457). May activate expression of PITX1 (PubMed:17984056). May regulate microRNA (miRNA) expression (PubMed:24145033). Inappropriate expression can inhibit myogenesis and promote apoptosis (PubMed:26951377, PubMed:28935672, PubMed:29618456)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 22,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E2JJS1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0031965 nuclear membrane",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q9UBX2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96JM2-1",
        "uniprot_id": "ZN462_HUMAN",
        "mass": 284688.0,
        "length": 2506,
        "protein_name": "Zinc finger protein 462",
        "gene_name": "ZNF462",
        "organism": "Human",
        "refseq_name": "zinc finger protein 462 isoform 1",
        "refseq_ac": "NP_067047",
        "gene_names_uniprotkb": "ZNF462; KIAA1803",
        "gene_names_refseq": "WSKA; ZFPIP; ZNF462; Zfp462",
        "protein_names_uniprotkb": "Zinc finger protein 462; ZFPIP; Zinc finger PBX1-interacting protein",
        "protein_names_refseq": "zinc finger PBX1-interacting protein; zinc finger protein 462 isoform 1",
        "tax_id": 9606,
        "disease": "generalized anxiety disorder (Disease Ontology:DOID:14320); Weiss-Kruszka syndrome (MONDO:MONDO:0032836)",
        "pathway": " (hsa:58499)",
        "pathway_count": 1,
        "publication_count": 58,
        "publication_id_list": "11237011;17081983;17525332;18978678;19266077;19664994;19664995;19690332;20219459;21406692;21570965;22826440;24129315;25114211;25218447;25576301;25755297;25772364;25880248;28513610;28904123;29393594;29427787;29557506;30315122;30379171;30410026;30429286;31154438;31217245;31361404;31844290;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32938616;32983136;33141586;33298915;33592498;33912179;33968037;33981976;34171305;34509645;35051231;35254053;35580925;36010968;36241641;36284347;36461789;39069253;39531497",
        "class_list": "",
        "function": "A multiple congenital anomaly syndrome associated with haploinsufficiency of ZNF462 that has distinct clinical characteristics and facial features, is reported., [RefSeq, PubMed]; Further characterization of the 9q31 microdeletion phenotype; delineation of a common region of overlap containing ZNF462., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Phenotypic spectrum in Weiss-Kruszka syndrome caused by ZNF462 variants: Three new patients and literature review. Review article, [RefSeq, PubMed]; The protein encoded by this gene belongs to C2H2-type zinc finger family of proteins. It contains multiple C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]., [RefSeq]; Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965)., [UniProtKB, UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 80,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T0T4;Q8N408",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q96JM2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N8Z6-1",
        "uniprot_id": "DCBD1_HUMAN",
        "mass": 77920.0,
        "length": 715,
        "protein_name": "Discoidin, CUB and LCCL domain-containing protein 1",
        "gene_name": "DCBLD1",
        "organism": "Human",
        "refseq_name": "discoidin, CUB and LCCL domain-containing protein 1 isoform 2 precursor",
        "refseq_ac": "NP_775945",
        "gene_names_uniprotkb": "DCBLD1",
        "gene_names_refseq": "DCBLD1; dJ94G16.1",
        "protein_names_uniprotkb": "Discoidin, CUB and LCCL domain-containing protein 1",
        "protein_names_refseq": "discoidin, CUB and LCCL domain-containing protein 1 isoform 2 precursor; discoidin, CUB and LCCL domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285761)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;11237011;17081983;23090970;23186163;23481700;24190977;25813380;25880248;25892735;27600516;28855257;28904123;29025973;29242379;29769354;31844290;32157095;32231272;32350084;32357974;32606017;33592498;34140574;34171305;34932366;35051231;35251023;36308382;37074911;38253038;38291438",
        "class_list": "",
        "function": "DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; FYN and ABL Regulate the Interaction Networks of the DCBLD Receptor Family., [RefSeq, PubMed]; Lactylation stabilizes DCBLD1 activating the pentose phosphate pathway to promote cervical cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; SNP rs17079281 decreases lung cancer risk through creating an YY1-binding site to suppress DCBLD1 expression., [RefSeq, PubMed]; SNP rs9387478 at ROS1-DCBLD1 Locus is Significantly Associated with Lung Cancer Risk and Poor Survival in Indian Population. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_n_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 39,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5H992;Q8IYK5;Q8N7L9;Q96NH2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q8N8Z6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51659-1",
        "uniprot_id": "DHB4_HUMAN",
        "mass": 79686.0,
        "length": 736,
        "protein_name": "Peroxisomal multifunctional enzyme type 2",
        "gene_name": "HSD17B4",
        "organism": "Human",
        "refseq_name": "peroxisomal multifunctional enzyme type 2 isoform 2",
        "refseq_ac": "NP_000405",
        "gene_names_uniprotkb": "HSD17B4; EDH17B4; SDR8C1",
        "gene_names_refseq": "DBP; HSD17B4; MFE-2; MFP-2; MPF-2; PRLTS1; SDR8C1",
        "protein_names_uniprotkb": "Peroxisomal multifunctional enzyme type 2; 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; D-bifunctional protein; DBP; MFE-2; MFP-2; Multifunctional protein 2; Short chain dehydrogenase/reductase family 8C member 1",
        "protein_names_refseq": "17-beta-HSD 4; 17-beta-HSD IV; 17-beta-hydroxysteroid dehydrogenase 4; 17beta-estradiol dehydrogenase type IV; 3-alpha,7-alpha, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; D-3-hydroxyacyl-CoA dehydratase; D-bifunctional protein, peroxisomal; beta-hydroxyacyl dehydrogenase; beta-keto-reductase; epididymis secretory sperm binding protein; hydroxysteroid dehydrogenase 4; peroxisomal multifunctional enzyme type 2 isoform 2; peroxisomal multifunctional enzyme type 2; peroxisomal multifunctional protein 2; short chain dehydrogenase/reductase family 8C member 1",
        "tax_id": 9606,
        "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); D-bifunctional protein deficiency (Disease Ontology:DOID:0090031); hypertension (Disease Ontology:DOID:10763); Stiff-Person syndrome (Disease Ontology:DOID:13366); lipid metabolism disorder (Disease Ontology:DOID:3146); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:3295);  (R-HSA-193368);  (R-HSA-2046106);  (R-HSA-389887);  (R-HSA-390247);  (R-HSA-9033241);  (R-HSA-9033500)",
        "pathway_count": 7,
        "publication_count": 255,
        "publication_id_list": "10.1101/2023.09.13.557529;10022913;10051404;10092594;10198260;10400999;10479480;10486279;10562279;10601301;10655068;10671535;10673331;10706581;10749848;10899997;10903473;11060344;11060359;11067870;11101887;11158055;11237011;11500517;11514237;11546814;11673457;11700068;11734571;11743515;11781871;11931631;11980911;11988075;12323085;12323090;12456682;12559034;12562770;12562861;12578380;12679481;12713571;12716664;12717447;12885776;12897190;1346092;1400444;14636670;15060085;15099582;15545321;15599942;15644212;15858711;16385454;1651711;16756494;16766224;1679347;16854980;16940157;17007944;1708392;17726030;1834642;18359941;18538142;18691976;18712838;18767875;19056654;19197237;19208625;19369195;19584060;19608861;19632994;20068231;20112406;20178365;2019602;20673864;21145416;21554508;21976670;21980954;22002062;22057399;22371489;22493507;22534643;22745130;22747494;23186163;23481700;2351134;2384150;23963456;24235149;24275569;24366607;24397554;24714562;24715725;24865970;25016021;25418920;25502872;25505266;25538232;25548167;25576301;25645385;25810538;25854684;25880248;25956234;26086376;26138649;26154972;26220973;26344566;26375851;26728094;26768311;26811146;26992070;27397612;27452731;27597759;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28467828;28510447;28521612;28611990;28649982;28765278;28787099;28832583;28834231;28904123;29242379;29314611;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30410026;30429286;30573663;30779550;30833945;31217245;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33115767;33123756;33141586;33298915;33465208;33500543;33537174;33592498;33691108;33717175;33912179;33935042;33936100;33968037;33981976;34087483;34185709;34211107;34357683;34725712;34932366;35051231;35154160;35251023;35318648;35561310;35580925;35951481;36010968;36241641;36284347;37217939;37378696;37938771;38253038;38665916;39052101;40596516;486181;6798973;7061494;7487879;7508385;7649182;7685190;7719337;7790377;8034703;8096621;8387517;8656081;8824437;8832760;8858165;8902629;8943006;8991089;9089413;9090381;9090382;9090383;9271077;9482850;9539740;9653144;9660774;9668159;9837948;9880674",
        "class_list": "",
        "function": "Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Exome sequencing reveals pathogenic mutations in the LARS2 and HSD17B4 genes associated with Perrault syndrome and D-bifunctional protein deficiency in Moroccan families. Publication Status: Online-Only, [RefSeq, PubMed]; HSD17B4 methylation enhances glucose dependence of BT-474 breast cancer cells and increases lapatinib sensitivity., [RefSeq, PubMed]; Rapid whole-genome sequencing identifies a homozygous novel variant, His540Arg, in HSD17B4 resulting in D-bifunctional protein deficiency disorder diagnosis. Publication Status: Online-Only, [RefSeq, PubMed]; The Peroxisomal Localization of Hsd17b4 Is Regulated by Its Interaction with Phosphatidylserine., [RefSeq, PubMed]; The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 6,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DNV1;B4DVS5;E9PB82;F5HE57",
        "ec_number_list": "4.2.1.134;1.1.1.n12;4.2.1.107;4.2.1.119;1.1.1.62;1.1.1.239",
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0004300 enoyl-CoA hydratase activity;GO:0016853 isomerase activity;GO:0018812 3-hydroxyacyl-CoA dehydratase activity",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0006633 fatty acid biosynthetic process;GO:0008209 androgen metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 26.3,
        "record_id": "P51659-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5VZ89-1",
        "uniprot_id": "DEN4C_HUMAN",
        "mass": 212711.0,
        "length": 1909,
        "protein_name": "DENN domain-containing protein 4C",
        "gene_name": "DENND4C",
        "organism": "Human",
        "refseq_name": "DENN domain-containing protein 4C isoform 2",
        "refseq_ac": "NP_001317569",
        "gene_names_uniprotkb": "DENND4C; C9orf55B; C9orf55",
        "gene_names_refseq": "C9orf55B; C9orf55; DENND4C; RAB10GEF; bA513M16.3",
        "protein_names_uniprotkb": "DENN domain-containing protein 4C",
        "protein_names_refseq": "DENN domain-containing protein 4C isoform 2; DENN domain-containing protein 4C; DENN/MADD domain containing 4A pseudogene; DENN/MADD domain containing 4C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55667);  (R-HSA-8876198)",
        "pathway_count": 2,
        "publication_count": 270,
        "publication_id_list": "10818110;10990452;11038176;11179213;11237011;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15096524;15138286;15144186;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17081983;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18669648;18701652;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19620288;19656848;19690332;19725050;19729655;19745841;20008558;20068231;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21406692;21421921;21445324;21454697;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22028470;22065758;22072793;22171327;22365832;22424782;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23186163;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23645161;23678941;23684622;23713133;23839779;24275569;24296415;24644286;24694596;24715725;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25472813;25576301;25648148;25713415;25925668;26055712;26154972;26177209;26245486;26434594;26538022;26811146;26925400;26936971;26992070;27041585;27044746;27103185;27246931;27329675;27846572;27862975;27920218;28063628;28218747;28228285;28514659;28649982;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30410026;30429286;30524438;31217245;31488193;31844290;32157095;32196590;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32938750;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34405274;34509645;34932366;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;36896567;37938771;38253038;38412628;7688123;7911226;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells., [RefSeq, PubMed]; CircDENND4C silence suppresses glycolysis, migration and invasion in breast cancer cells under hypoxia by increasing miR-200b and miR-200c. Publication Status: Online-Only, [RefSeq, PubMed]; CircDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c., [RefSeq, PubMed]; Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin., [UniProtKB, PubMed]; Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 28,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 44,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A3R1;A2A3R2;A2A3R3;A2A3R9;Q6AI48;Q6ZUB3;Q8NCY7;Q9H6N4;Q9NUT1;Q9NWA5;Q9NWT3;R4GN35;R4GNB2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031410 cytoplasmic vesicle",
        "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0015031 protein transport;GO:0032869 cellular response to insulin stimulus;GO:0072659 protein localization to plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 27.5,
        "record_id": "Q5VZ89-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95631-1",
        "uniprot_id": "NET1_HUMAN",
        "mass": 67748.0,
        "length": 604,
        "protein_name": "Netrin-1",
        "gene_name": "NTN1",
        "organism": "Human",
        "refseq_name": "netrin-1 precursor",
        "refseq_ac": "NP_004813",
        "gene_names_uniprotkb": "NTN1; NTN1L",
        "gene_names_refseq": "MRMV4; NET1; NTN1L; NTN1",
        "protein_names_uniprotkb": "Netrin-1; Epididymis tissue protein Li 131P",
        "protein_names_refseq": "Netrin-1; epididymis tissue protein Li 131P; netrin 1, mouse, homolog of; netrin-1 precursor",
        "tax_id": 9606,
        "disease": "mirror movements 4 (Disease Ontology:DOID:0070638)",
        "pathway": " (hsa:9423);  (R-HSA-373752);  (R-HSA-376172);  (R-HSA-418885);  (R-HSA-418886);  (R-HSA-418890);  (R-HSA-428542)",
        "pathway_count": 7,
        "publication_count": 51,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10925149;10995436;11237011;11453658;11817894;12149262;12154370;12810718;15040784;15343335;15494732;15494734;15557120;15574733;15788770;15960985;16762451;17174565;18066058;18212043;18216854;18216855;18253061;19196994;20736409;23090970;23584533;24190977;24936616;25123307;26586761;28483977;28904123;28945198;29242379;29741879;31844290;31848261;32357974;34357683;38289148;38314870;38725153;38856164;39023520;39261771;8861902;9858595;9950216",
        "class_list": "",
        "function": "Circulating netrin-1 levels are reduced and related to corneal nerve fiber loss in patients with diabetic neuropathy., [RefSeq, PubMed]; Netrin is included in a family of laminin-related secreted proteins.  The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development.  Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]., [RefSeq]; Netrin signaling mediates survival of dormant epithelial ovarian cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; Netrin-1-CD146 and netrin-1-S100A9 are associated with early stage of lymph node metastasis in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335)., [UniProtKB, PubMed, PubMed]; Possible Role of Netrin-1/Deleted in Colorectal Cancer/Vascular Endothelial Growth Factor Signaling Pathway in the Pathogenesis of Placenta Accreta Spectrum: A Case-control Study., [RefSeq, PubMed]; Proteins linking APOE varepsilon4 with Alzheimer's disease., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 1,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9KL51",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005604 basement membrane",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0007265 Ras protein signal transduction;GO:0051963 regulation of synapse assembly;GO:0045773 positive regulation of axon extension",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "O95631-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "V9GZ13-1",
        "uniprot_id": "V9GZ13_HUMAN",
        "mass": 5800.0,
        "length": 50,
        "protein_name": "Uncharacterized protein",
        "gene_name": "LOC128706666",
        "organism": "Human",
        "refseq_name": "uncharacterized LOC128706666",
        "refseq_ac": "NP_001381078",
        "gene_names_uniprotkb": "LOC128706666",
        "gene_names_refseq": "LOC128706666",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "uncharacterized LOC128706666",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:128706666)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
        "function": "This gene encodes a short, well-conserved protein that is localized to the mitochondrial membrane. The encoded protein has been implicated in repression of translation of the downstream molecular chaperone MKKS protein. [provided by RefSeq, Mar 2023]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "V9GZ13-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96GQ7-1",
        "uniprot_id": "DDX27_HUMAN",
        "mass": 86605.0,
        "length": 765,
        "protein_name": "Probable ATP-dependent RNA helicase DDX27",
        "gene_name": "DDX27",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DDX27; HSPC259; PP3241; RHLP; cPERP-F",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX27; 3.6.4.13; DEAD box protein 27",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55661)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;15498874;18669648;20068231;20813266;23186163;25825154;30429286",
        "class_list": "",
        "function": "Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA (PubMed:25825154)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVB6;B3GQE6;B7Z6D5;B7ZLY1;Q5VXM7;Q8WYG4;Q969N7;Q96F57;Q96L97;Q9BWY9;Q9BXF0;Q9H990;Q9NWU3;Q9P0C2;Q9UGD6",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome",
        "go_biological_process": "GO:0006364 rRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q96GQ7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P14061-1",
        "uniprot_id": "DHB1_HUMAN",
        "mass": 34950.0,
        "length": 328,
        "protein_name": "17-beta-hydroxysteroid dehydrogenase type 1",
        "gene_name": "HSD17B1",
        "organism": "Human",
        "refseq_name": "17-beta-hydroxysteroid dehydrogenase type 1 isoform 1",
        "refseq_ac": "NP_000404",
        "gene_names_uniprotkb": "HSD17B1; E17KSR; EDH17B1; EDH17B2; EDHB17; SDR28C1",
        "gene_names_refseq": "17-beta-HSD; 20-alpha-HSD; E2DH; EDH17B2; EDHB17; HSD17B1; HSD17; SDR28C1",
        "protein_names_uniprotkb": "17-beta-hydroxysteroid dehydrogenase type 1; 1.1.1.51; 1.1.1.62; 17-beta-HSD 1; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Estradiol 17-beta-dehydrogenase 1; Placental 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 28C member 1",
        "protein_names_refseq": "17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1 isoform 1; 17-beta-hydroxysteroid dehydrogenase type 1; 20 alpha-hydroxysteroid dehydrogenase; estradiol 17-beta-dehydrogenase 1; placental 17-beta-hydroxysteroid dehydrogenase; short chain dehydrogenase/reductase family 28C member 1; short chain dehydrogenase/reductase family 28CE, member 1",
        "tax_id": 9606,
        "disease": "invasive ductal carcinoma (Disease Ontology:DOID:3008)",
        "pathway": " (hsa:3292);  (R-HSA-193144);  (R-HSA-2453902)",
        "pathway_count": 3,
        "publication_count": 87,
        "publication_id_list": "10075733;10617778;10625652;10753906;11123914;11237011;11274389;11895893;12036956;12177057;12223444;12404296;12407145;12490543;12697717;1327779;14966133;15314061;15471866;15865448;16332571;17067289;17255476;1825337;19027824;19049981;1925597;19309693;20192770;21493626;2149502;2171939;21774515;2197970;22665496;22792371;2303470;2330005;2542268;2547159;25577493;25892735;26230928;27102893;27600516;2779584;2846351;28649982;29769354;31154438;31222486;3170584;32157095;33968037;34171305;3456799;34764940;35563206;36634828;38780059;4719204;5045524;5315589;6288450;6342691;6512705;6578212;6589631;6679757;7336466;7663947;7929238;8076586;8099587;8105993;8389226;8756321;8805577;8884265;8994190;9490294;9525918;9541407;9703434;9783542;9920938;9927655",
        "class_list": "",
        "function": "Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH., [UniProtKB, PubMed]; Favors the reduction of estrogens and androgens. Uses preferentially NADH., [UniProtKB, UniProtKB]; New insights into the substrate inhibition of human 17beta-hydroxysteroid dehydrogenase type 1., [RefSeq, PubMed]; Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Serum hydroxysteroid (17beta) dehydrogenase 1 concentration in pregnant women correlates with pregnancy-associated plasma protein A but does not serve as an independent marker for preeclampsiadagger., [RefSeq, PubMed]; Steroid Metabolism in Children and Adolescents With Obesity and Insulin Resistance: Altered SRD5A and 20alpha/20betaHSD Activity. Publication Status: Online-Only, [RefSeq, PubMed]; The structure of human 17beta-HSD1 and biological function have been studied extensively in the last two decades. In humans, the enzyme is expressed in placenta, ovary, endometrium and breast; high activity of estrogen activation provides the basis of 17beta-HSD1's implication in estrogen-dependent diseases, such as breast cancer, endometriosis and non-small cell lung carcinomas. [Review] Review article, [RefSeq, PubMed]; This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KXS1;Q2M2L8",
        "ec_number_list": "1.1.1.300;1.1.1.-;1.1.1.64;1.1.1.54;1.1.1.216;1.1.1.62;1.1.1.239;1.1.1.105;1.1.1.209;1.1.1.53;1.1.1.51;1.1.1.225;1.1.1.357;1.1.1.210;1.1.1.188;1.1.1.112;1.3.1.20;1.1.1.270;1.1.1.149;1.1.1.330;1.1.1.n12;1.1.1.35;1.1.1.178;1.1.1.159",
        "go_molecular_function": "GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0042803 protein homodimerization activity;GO:0005496 steroid binding;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0036094 small molecule binding",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0006703 estrogen biosynthetic process;GO:0060348 bone development;GO:0061370 testosterone biosynthetic process;GO:0071248 cellular response to metal ion",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "P14061-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q01459-1",
        "uniprot_id": "DIAC_HUMAN",
        "mass": 43760.0,
        "length": 385,
        "protein_name": "Di-N-acetylchitobiase",
        "gene_name": "CTBS",
        "organism": "Human",
        "refseq_name": "di-N-acetylchitobiase precursor",
        "refseq_ac": "NP_004379",
        "gene_names_uniprotkb": "CTBS; CTB",
        "gene_names_refseq": "CTBS; CTB",
        "protein_names_uniprotkb": "Di-N-acetylchitobiase; 3.2.1.-",
        "protein_names_refseq": "chitobiase, di-N-acetyl-; di-N-acetylchitobiase precursor; di-N-acetylchitobiase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1486)",
        "pathway_count": 1,
        "publication_count": 56,
        "publication_id_list": "37639587;10.1101/2023.09.13.557529;10336991;11237011;1527079;16115860;16794344;19159218;23090970;23481700;24190977;24366607;24714562;25576301;26375851;26728094;26768631;26992070;27600516;27846572;27862975;27920218;28467828;28514659;28832583;28834231;28904123;29242379;29493099;29557506;29632711;29741879;29786170;31154438;31530632;31844290;31848261;32161166;32350084;32488085;32502341;32938616;32983136;33091337;33592498;33912179;33968037;34171305;35051231;35154160;35251023;35580925;36010968;37074911;37217939;37938771",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "Biochemical behavior of di-N-acetylchitobiase indicates it has three subsites, -2, -1, +1, in which the reducing-end trimer of any sized chitooligosaccharide is bound. The +1 site is specific for an alpha-anomer., [RefSeq, PubMed]; Chitobiase is a lysosomal glycosidase involved in degradation of asparagine-linked oligosaccharides on glycoproteins (Aronson and Kuranda, 1989 [PubMed 2531691]).[supplied by OMIM, Nov 2010]., [RefSeq]; Data indicate that infliximab changes the concentration of hexosaminidase (N-acetyl-beta-glucosaminidase; HEX) activity depending on the drug dose and time of administration., [RefSeq, PubMed]; Reducing-end exoglycosidase involved in glycan degradation (PubMed:1527079, PubMed:16115860). Hydrolyzes N,N'-diacetylchitobiose (GlnNAc2) and higher chitin-oligosaccharides (GlcNAc(n)) to monomeric GlcNAc acting on reducing-end residues (PubMed:1527079, PubMed:16115860, PubMed:16794344). During N-linked glycoprotein degradation, it cleaves single GlcNAc molecules uniquely from the reducing end of N,N'-diacetylchitobiose units linking oligosaccharides to proteins, and therefore it functions after cleavage of the Asn-GlcNAc bond and asparagine removal by glycosylasparaginase (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 491,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 22,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VX50",
        "ec_number_list": "3.2.1.-",
        "go_molecular_function": "GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0004568 chitinase activity;GO:0008061 chitin binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome",
        "go_biological_process": "GO:0016052 carbohydrate catabolic process;GO:0006032 chitin catabolic process;GO:0009313 oligosaccharide catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "Q01459-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75064-1",
        "uniprot_id": "DEN4B_HUMAN",
        "mass": 163847.0,
        "length": 1496,
        "protein_name": "DENN domain-containing protein 4B",
        "gene_name": "DENND4B",
        "organism": "Human",
        "refseq_name": "DENN domain-containing protein 4B isoform 1",
        "refseq_ac": "NP_055671",
        "gene_names_uniprotkb": "DENND4B; KIAA0476",
        "gene_names_refseq": "DENND4B; KIAA0476",
        "protein_names_uniprotkb": "DENN domain-containing protein 4B",
        "protein_names_refseq": "DENN domain-containing protein 4B isoform 1; DENN domain-containing protein 4B; DENN/MADD domain containing 4B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9909);  (R-HSA-8876198)",
        "pathway_count": 2,
        "publication_count": 236,
        "publication_id_list": "10818110;10990452;11038176;11179213;11237011;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12906859;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18701652;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19620288;19656848;19725050;19729655;19745841;20008558;20112406;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23186163;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23481700;23645161;23678941;23684622;23713133;23839779;24296415;24644286;24694596;24715725;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25418920;25469497;25472813;25576301;25645385;25648148;25713415;25892735;25925668;26055712;26154972;26177209;26245486;26434594;26538022;26811146;26925400;26936971;26992070;27041585;27044746;27103185;27246931;27329675;27846572;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29769354;29786170;30315122;30379171;30410026;31217245;31844290;32157095;32357974;32387766;32488085;32502341;32938616;32983136;33123756;33298915;33717175;33912179;33968037;34185709;34509645;34561969;34932366;35051231;35580925;36010968;37217939;7688123;7911226;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T4K0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle",
        "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 23.9,
        "record_id": "O75064-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00273-1",
        "uniprot_id": "DFFA_HUMAN",
        "mass": 36522.0,
        "length": 331,
        "protein_name": "DNA fragmentation factor subunit alpha",
        "gene_name": "DFFA",
        "organism": "Human",
        "refseq_name": "DNA fragmentation factor subunit alpha isoform 1",
        "refseq_ac": "NP_004392",
        "gene_names_uniprotkb": "DFFA; DFF1; DFF45; H13",
        "gene_names_refseq": "DFF-45; DFF1; DFFA; ICAD",
        "protein_names_uniprotkb": "DNA fragmentation factor subunit alpha; DFF-45; DNA fragmentation factor 45 kDa subunit; ICAD; Inhibitor of CAD",
        "protein_names_refseq": "DFF45; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha isoform 1; DNA fragmentation factor, 45kDa, alpha polypeptide; inhibitor of CAD",
        "tax_id": 9606,
        "disease": "mucopolysaccharidosis (Disease Ontology:DOID:12798); mucopolysaccharidosis type VII (Disease Ontology:DOID:12803); peritonitis (Disease Ontology:DOID:8283)",
        "pathway": " (hsa:1676);  (R-HSA-140342)",
        "pathway_count": 2,
        "publication_count": 88,
        "publication_id_list": "10318789;10409614;10497265;10713148;11237011;11371636;12748178;15149602;15569692;15910001;16408927;16964243;17322306;17525332;17924679;17938174;18077418;18239742;18283539;18491316;18669648;18767875;19413330;19651622;20068231;20166139;20230923;21406692;21993680;22223895;22424782;23186163;23301498;23481700;24035784;24275569;24714562;24715725;25418920;25645385;25880248;26992070;27543614;27600516;27920218;28228285;28510447;28514659;28832583;28904123;28914671;29091952;29242379;29393594;29508533;30315122;30410026;30429286;30524438;30833945;31217245;31222486;31844290;31848261;32157095;32357974;32488085;32502341;32897882;32938616;32983136;33298915;33592498;33691108;33968037;33981976;34019948;34087483;34171305;34229054;34509645;35008409;35051231;35580925;36010968;36241641;38665916;9108473",
        "class_list": "",
        "function": "Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Evaluate the relative expression levels of miR-196a2 and three of its selected apoptosis-related targets; ANXA1, DFFA and PDCD4 in a sample of GI cancer patients Publication Status: Online-Only, [RefSeq, PubMed]; Glandular, menopause-independent DFF40, DFF45, and Bcl-2 overexpression may play an important role in the pathogenesis of endometrial polyps and benign endometrial hyperplasia, [RefSeq, PubMed]; Inhibitor of the caspase-activated DNase (DFF40)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T6G5;Q5T6G6;Q96I97;Q9Y6C6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0060703 deoxyribonuclease inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0006915 apoptotic process;GO:0006309 apoptotic DNA fragmentation;GO:1900118 negative regulation of execution phase of apoptosis;GO:1902511 negative regulation of apoptotic DNA fragmentation;GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "O00273-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15263-1",
        "uniprot_id": "DFB4A_HUMAN",
        "mass": 7038.0,
        "length": 64,
        "protein_name": "Defensin beta 4A",
        "gene_name": "DEFB4A; DEFB4B",
        "organism": "Human",
        "refseq_name": "beta-defensin 4B precursor",
        "refseq_ac": "NP_001192195",
        "gene_names_uniprotkb": "DEFB4A; DEFB4B; DEFB102; DEFB2; DEFB4",
        "gene_names_refseq": "DEFB4B; DEFB4P",
        "protein_names_uniprotkb": "Defensin beta 4A; BD-2; Beta-defensin 2; Defensin, beta 2; SAP1; Skin-antimicrobial peptide 1; hBD-2",
        "protein_names_refseq": "beta defensin 2; beta-defensin 4B precursor; defensin, beta 4, pseudogene",
        "tax_id": 9606,
        "disease": "common cold (Disease Ontology:DOID:10459); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cystic fibrosis (Disease Ontology:DOID:1485); pulmonary fibrosis (Disease Ontology:DOID:3770); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874)",
        "pathway": " (hsa:100289462);  (hsa:1673);  (R-HSA-1461957);  (R-HSA-1461973)",
        "pathway_count": 4,
        "publication_count": 25,
        "publication_id_list": "10521347;10603376;10837369;10906336;10914484;11085990;11300761;11702237;11714914;11934878;12010514;12949495;18006661;20068036;20214904;20385753;20483750;21122132;30050988;31682009;33717182;9202117;9541493;9727055;9831658",
        "class_list": "",
        "function": "DEFB4B expression is significantly downregulated in healthy palatal mucosa of smokers, [RefSeq, PubMed]; Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]., [RefSeq]; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria (PubMed:10837369, PubMed:9202117). Antimicrobial activity against P.aeruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM (PubMed:10837369). Also exhibits antimicrobial activity against the yeast C.albicans (PubMed:10837369, PubMed:30050988, PubMed:9202117). Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell fragmentation and cell death (PubMed:30050988). Acts as a ligand for C-C chemokine receptor CCR6 (PubMed:10521347, PubMed:20068036). Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells, such as immature dendritic cells and memory T cells (PubMed:10521347, PubMed:20068036)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Human beta-Defensin 2 Mutations Are Associated With Asthma and Atopy in Children and Its Application Prevents Atopic Asthma in a Mouse Model. Publication Status: Online-Only, [RefSeq, PubMed]; The encoded peptide has antimicrobial activity against E.coli, S. aureus, and P. aeruginosa., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q52LC0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005796 Golgi lumen",
        "go_biological_process": "GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "O15263-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60879-1",
        "uniprot_id": "DIAP2_HUMAN",
        "mass": 125569.0,
        "length": 1101,
        "protein_name": "Protein diaphanous homolog 2",
        "gene_name": "DIAPH2",
        "organism": "Human",
        "refseq_name": "protein diaphanous homolog 2 isoform 156",
        "refseq_ac": "NP_006720",
        "gene_names_uniprotkb": "DIAPH2; DIA",
        "gene_names_refseq": "DIA2; DIAPH2; DIA; DRF2; POF2A; POF2; POF",
        "protein_names_uniprotkb": "Protein diaphanous homolog 2; DRF2; Diaphanous-related formin-2",
        "protein_names_refseq": "Premature ovarian failure 2A; diaphanous homolog 2; diaphorase-2; protein diaphanous homolog 2 isoform 156",
        "tax_id": 9606,
        "disease": "autosomal dominant auditory neuropathy 1 (Disease Ontology:DOID:0060690); primary ovarian insufficiency 2A (Disease Ontology:DOID:0080858); microcephaly (Disease Ontology:DOID:10907); leiomyoma (Disease Ontology:DOID:127); breast cancer (Disease Ontology:DOID:1612); primary ovarian insufficiency (Disease Ontology:DOID:5426); in situ carcinoma (Disease Ontology:DOID:8719); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:1730);  (R-HSA-9035034)",
        "pathway_count": 2,
        "publication_count": 58,
        "publication_id_list": "12577064;16777452;17081983;17765681;20233848;21119010;21397845;23096567;24715725;25668492;25880248;26811146;26992070;27278019;27481945;27600516;27846572;27920218;28228285;28514659;28832583;28904123;29242379;29393594;29437277;29508533;29557506;29596520;29632711;29786170;30315122;30593440;30793164;31844290;31871319;32157095;32357974;32387766;32897882;32938616;32983136;33298915;33592498;33691108;33717175;33912179;33936100;33968037;34087483;34171305;34299935;34509645;35051231;35580925;36215666;36284347;38844723;9497258",
        "class_list": "",
        "function": "Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton., [UniProtKB, PubMed]; DIAPH2 gene expression was an independent prognostic factors of clinical pregnancy rate and live birth in ICSI pregnancies., [RefSeq, PubMed]; DIAPH2 gene polymorphisms and laryngeal cancer risk in men. Publication Status: Online-Only, [RefSeq, PubMed]; DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk. Publication Status: Online-Only, [RefSeq, PubMed]; Low DIA2 expression is associated with breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Low DIAPH2 expression is associated with metastasis of laryngeal squamous cell carcinoma., [RefSeq, PubMed]; The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 9,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NG19;O60878;Q8WX06;Q8WX48;Q9UJL2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005884 actin filament",
        "go_biological_process": "GO:0030041 actin filament polymerization;GO:0048477 oogenesis;GO:0007292 female gamete generation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "O60879-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95424-1",
        "uniprot_id": "DEXI_HUMAN",
        "mass": 10429.0,
        "length": 95,
        "protein_name": "Dexamethasone-induced protein",
        "gene_name": "DEXI",
        "organism": "Human",
        "refseq_name": "dexamethasone-induced protein",
        "refseq_ac": "NP_054734",
        "gene_names_uniprotkb": "DEXI; MYLE",
        "gene_names_refseq": "DEXI; MYLE",
        "protein_names_uniprotkb": "Dexamethasone-induced protein; Protein MYLE",
        "protein_names_refseq": "dexamethasone-induced protein; dexamethasone-induced transcript",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:28955)",
        "pathway_count": 1,
        "publication_count": 28,
        "publication_id_list": "11472984;21901246;23151489;25008175;25576301;25880248;28832583;29557506;29769354;30315122;30429286;30478640;30779550;31154438;31222486;31844290;31848261;32157095;32357974;32502341;32983136;33592498;33981976;34932366;35154160;35580925;36241641;36284347",
        "class_list": "",
        "function": "Reduced DEXI mRNA level was associated with type 1 diabetes risk alleles of CLEC16A., [RefSeq, PubMed]; Silencing of DEXI leads to drug resistance in colon cancer., [RefSeq, PubMed]; The data indicates a possible regulatory role for multiple sclerosis-associated non-coding CLEC16A SNPs and a common control mechanism for the expression of CLEC16A, SOCS1 and DEXI., [RefSeq, PubMed]; These observations support DEXI as the aetiological gene in the type 1 diabetes-associated 16p13 genomic region, and provide the first indication of a link between this candidate gene and the regulation of local antiviral immune responses in beta cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RAA7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "O95424-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P12838-1",
        "uniprot_id": "DEF4_HUMAN",
        "mass": 10504.0,
        "length": 97,
        "protein_name": "Defensin alpha 4",
        "gene_name": "DEFA4",
        "organism": "Human",
        "refseq_name": "defensin alpha 4 preproprotein",
        "refseq_ac": "NP_001916",
        "gene_names_uniprotkb": "DEFA4; DEF4",
        "gene_names_refseq": "DEF4; DEFA4; HNP-4; HP-4; HP4",
        "protein_names_uniprotkb": "Defensin alpha 4; Corticostatin HP-4; HNP-4; HP-4; Neutrophil defensin 4",
        "protein_names_refseq": "corticostatin HP-4; corticostatin; defensin alpha 4 preproprotein; defensin, alpha 4, corticostatin; defensin, alpha 4, preproprotein; neutrophil defensin 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1669);  (R-HSA-1461973);  (R-HSA-1462054);  (R-HSA-6798695)",
        "pathway_count": 4,
        "publication_count": 35,
        "publication_id_list": "10618521;12021776;12060767;12949495;1302183;1339298;1445872;15210812;15317502;1547345;15616305;15620707;16959974;17088326;18973303;2006422;20214904;20385753;20727496;21734341;23050799;23650620;2500436;2501794;2668334;2843187;29446150;29557506;2997278;30658057;7833799;8329717;8469233;8692836;9169779",
        "class_list": "",
        "function": "DEFA1-3 and DEFA4 mRNA level in peripheral blood cells can be used to identify chronic myeloid leukaemia patients who are at risk of being imatinib-resistant, before initiation of the therapy., [RefSeq, PubMed]; DEFA4 displays antimicrobial activity against E. coli, S. faecalis, and C. albicans., [RefSeq, PubMed]; Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014]., [RefSeq]; Findings unveil the molecular determinants of HNP4 function, completing the atlas of structure and function relationships for all human neutrophil alpha-defensins., [RefSeq, PubMed]; Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi (PubMed:15317502, PubMed:15616305, PubMed:2500436, PubMed:2501794, PubMed:30658057). Exhibits antimicrobial activity against Gram-negative E.coli and E.aerogenes and Gram-positive S.faecalis, S.aureus and B.cereus and the yeast C.albicans (in vitro) (PubMed:15317502, PubMed:15616305, PubMed:17088326, PubMed:2500436, PubMed:2501794, PubMed:30658057). Interacts with pathogenic surface proteins and toxins, such as HIV-1 surface protein gp120 and B.anthracis anthrax lethal factor lef (PubMed:15620707, PubMed:30658057). Protects blood cells against infection with HIV-1 (in vitro) (PubMed:15620707). Inhibits enzymatic activity of B.anthracis lef/anthrax lethal factor (in vitro) (PubMed:30658057). Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro) (PubMed:2843187)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Results indicate that the gene expression of DEFA 1/3 and 4 was significantly increased in all tumours - except for a significant decrease of DEFA 4 gene expression in pleomorphic adenomas. Publication Status: Online-Only, [RefSeq, PubMed]; The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, epidermal growth factor, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation., [RefSeq, PubMed]; Three AMP genes, histatin 3 (HTN3), alpha-defensin 4 (DEFA4) and lysozyme C (LYZ), presented different expression levels in periodontitis patients compared with healthy subjects. The relative expression level of DEFA4 appeared to be a protective factor against periodontitis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 14,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6EZF8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0035580 specific granule lumen;GO:0030133 transport vesicle",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0019732 antifungal humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "P12838-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P15924-1",
        "uniprot_id": "DESP_HUMAN",
        "mass": 331774.0,
        "length": 2871,
        "protein_name": "Desmoplakin",
        "gene_name": "DSP",
        "organism": "Human",
        "refseq_name": "desmoplakin isoform II",
        "refseq_ac": "NP_001008844",
        "gene_names_uniprotkb": "DSP",
        "gene_names_refseq": "DCWHKTA; DP; DSP",
        "protein_names_uniprotkb": "Desmoplakin; 250/210 kDa paraneoplastic pemphigus antigen; DP",
        "protein_names_refseq": "250/210 kDa paraneoplastic pemphigus antigen; desmoplakin isoform II",
        "tax_id": 9606,
        "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); amyotrophic lateral sclerosis type 21 (Disease Ontology:DOID:0060212); keratosis palmoplantaris striata 2 (Disease Ontology:DOID:0081109); Carvajal syndrome (Disease Ontology:DOID:0090128); arrhythmogenic right ventricular dysplasia 8 (Disease Ontology:DOID:0110076); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); lethal acantholytic epidermolysis bullosa (MONDO:MONDO:0012323); severe dermatitis-multiple allergies-metabolic wasting syndrome (MONDO:MONDO:0014218); cardiomyopathy, dilated, with wooly hair, keratoderma, and tooth agenesis (MONDO:MONDO:0014355)",
        "pathway": " (hsa:1832);  (R-HSA-351906);  (R-HSA-6798695);  (R-HSA-6805567);  (R-HSA-6809371);  (R-HSA-9696264);  (R-HSA-9696273)",
        "pathway_count": 7,
        "publication_count": 233,
        "publication_id_list": "10.1101/2023.09.13.557529;10066784;10196183;10231017;10411887;10588656;10594734;10664463;10748026;10771479;10852826;11063735;11076937;11237011;11350120;11380615;11500511;11590230;11784792;11790773;11841538;11940653;12101406;12373648;12482924;12842009;12875771;12902340;15033990;15054114;15302935;15337775;15373777;15738000;15797384;15803139;15941723;16061697;16175511;16286477;16382671;16565220;16628197;16639001;1689290;1691188;16917092;1694855;17081983;1714783;17287340;1731325;17322306;17389395;17475244;17515931;17521629;17559062;17562024;17596512;18083107;18212344;18220336;18343367;18452278;18491316;18662195;18669648;18691976;18767875;18843291;18996843;19007248;19103606;19190773;19194479;19413330;19415658;19651622;19664994;19664995;19691289;19863551;20031617;20068230;20068231;20112406;20166139;20179351;20524011;20657595;20667819;20811643;20859650;20934997;20940292;20940358;21062920;21406692;21439340;21536047;21654840;21756917;21997417;22544926;22781308;22795705;22949226;23186163;23301498;23444369;23481192;23481700;23629652;23650620;23783831;24029068;2414304;24275569;24690281;24715725;25208567;25208914;25225338;25227139;25576301;25616123;25645385;25733715;25926655;26073755;26374642;26375851;26390218;26604139;26808545;26853435;26969432;26992070;27188911;27397612;27600516;27846572;27862975;28442525;28527814;28834231;28891468;29034528;29242379;29314611;29331515;29393594;29508533;29557506;29607617;29786170;29789417;29878302;30160835;30315122;30354334;30379171;30397120;30429286;30444036;30479852;30484775;30524438;30626607;30779550;30833945;31154438;31222486;31530632;31595153;31844290;31848261;31871319;32157095;32161166;32265295;32387766;32410525;32488085;32808748;32938616;32983136;33214551;33298915;33392160;33592498;33596089;33633747;33912179;33968037;33981976;34019948;34078123;34087483;34171305;34185709;34211107;34229054;35051231;35083852;35318648;35348702;35470109;35580925;35705054;36010968;36215666;36241641;36284347;36768812;37938771;38509711;38665916;39336825;40596516;7525582;7543090;8649376;8692836;8824274;8999895;9348293;9395522;9468612;9531558;9565599;9887343",
        "class_list": "",
        "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25733715). Critical for cell-cell adhesion in early stage blastocysts and progression through proamniotic cavity formation (By similarity). Not required for preimplantation morphogenic process in blastocysts (By similarity). Required for keratin filament anchoring at the desmosome junction and subsequent organization of the keratin intermediate filament network within the cytoplasm (By similarity). Required for anchoring of desmosomes to the microtubule architecture, via its interaction with NIN (By similarity). Promotes microtubule-mediated GJA1/CX43 trafficking to cell membranes via its interaction with MAPRE1/EB1, thereby facilitating gap junction intracellular communication (PubMed:25225338). Plays a key role in adhesion and organization of the dermal epithelial barrier (PubMed:26604139). Critical for the maintenance of the neural tube structure following formation and organization of the neuroepithelium (By similarity). Facilitates outgrowth and repair of motor neuron fibers in regenerating axons following injury, probably by promoting recruitment of a complex containing DSP, CDH2, VIM and JUP to the outgrowth tips (By similarity). Critical for the normal formation of heart and myocardial tissue during early embryogenesis (By similarity). Also required for development of vascular capillary structures and intact endothelial cell barriers (By similarity). Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). Maintains cardiac rhythmicity by ensuring correct cell-cell adhesion within the sinoatrial node, via stabilization of protein components of both desmosome and Gap junctions (By similarity). Involved in maintaining the protein stability and recruitment of GJA1 to functional gap junctions, via inhibition of KRAS-mediated MAPK1/MAPK3 phosphorylation of GJA1 (By similarity). Negative regulator of cell cycle progression and differentiation in keratinocytes, potentially via inhibition of MAPK and phosphoinositide-3-kinase (PI3K) signaling pathways (PubMed:17475244). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (PubMed:28891468). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (PubMed:28891468). Required for the maintenance of protein abundance of desmosome junction components DSG1, DSG2, DSC2, DSC3, PKP1, PKP2 and PKP3 (PubMed:17475244, PubMed:26073755). Required for the survival and maintenance of germ cells in the gonads during embryonic development (By similarity). Binds to telomere DNA (via C-terminus) and acts to prevent telomere damage and maintain telomere length via its interaction with TRF2 (PubMed:31595153)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; A novel minor isoform of desmoplakin that is also produced by alternative splicing of the desmoplakin gene, is described., [RefSeq, PubMed]; DSP-Related Cardiomyopathy as a Distinct Clinical Entity? Emerging Evidence from an Italian Cohort. Publication Status: Online-Only, [RefSeq, PubMed]; Epidermal growth factor receptor inhibition leads to cellular phenotype correction of DSP-mutated keratinocytes., [RefSeq, PubMed]; The Desmoplakin Phenotype Spectrum: Is the Inflammation the 'Fil Rouge' Linking Myocarditis, Arrhythmogenic Cardiomyopathy, and Uncommon Autoinflammatory Systemic Disease? Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 64,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 99,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 10,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RTT2;D7RX09;O75993;Q14189;Q9UHN4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005200 structural constituent of cytoskeleton;GO:0005080 protein kinase C binding;GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016323 basolateral plasma membrane",
        "go_biological_process": "GO:0150105 protein localization to cell-cell junction;GO:0008544 epidermis development;GO:0086091 regulation of heart rate by cardiac conduction;GO:0030216 keratinocyte differentiation;GO:0098609 cell-cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 24.3,
        "record_id": "P15924-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P37058-1",
        "uniprot_id": "DHB3_HUMAN",
        "mass": 34516.0,
        "length": 310,
        "protein_name": "17-beta-hydroxysteroid dehydrogenase type 3",
        "gene_name": "HSD17B3",
        "organism": "Human",
        "refseq_name": "17-beta-hydroxysteroid dehydrogenase type 3",
        "refseq_ac": "NP_000188",
        "gene_names_uniprotkb": "HSD17B3; EDH17B3; SDR12C2",
        "gene_names_refseq": "EDH17B3; HSD17B3; SDR12C2",
        "protein_names_uniprotkb": "17-beta-hydroxysteroid dehydrogenase type 3; 1.1.1.62; 1.1.1.64; 17-beta-HSD 3; Estradiol 17-beta-dehydrogenase 2; Short chain dehydrogenase/reductase family 12C member 2; Testicular 17-beta-hydroxysteroid dehydrogenase; Testosterone 17-beta-dehydrogenase 3",
        "protein_names_refseq": "17-beta-HSD 3; 17-beta-HSD3; 17-beta-hydroxysteroid dehydrogenase type 3; estradiol 17-beta-dehydrogenase 2; hydroxysteroid dehydrogenase 3; short chain dehydrogenase/reductase family 12C member 2; testicular 17-beta-hydroxysteroid dehydrogenase; testosterone 17-beta-dehydrogenase 3",
        "tax_id": 9606,
        "disease": "17-beta hydroxysteroid dehydrogenase 3 deficiency (Disease Ontology:DOID:0112248); Alzheimer's disease (Disease Ontology:DOID:10652); disorder of sexual development (Disease Ontology:DOID:1923); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:3293);  (R-HSA-193048);  (R-HSA-75876)",
        "pathway_count": 3,
        "publication_count": 57,
        "publication_id_list": "10406467;10548543;10954726;11158067;11237011;11889465;12210481;12371743;12482854;12525535;1279965;12975357;15469937;16036915;16216911;16371355;1712709;17379924;17681178;17762044;17986282;18003621;18318566;18554506;18728184;1944596;19505953;19826053;19879888;19936164;20937905;21959040;2197970;2243100;2339109;23856005;2534550;25961201;26545797;27927697;28514659;3207614;32372306;34087483;34885749;35051231;36154887;36563763;3783591;8075637;8547185;8550739;9208814;9536209;9709959;9758445;9871428",
        "class_list": "",
        "function": "Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids (PubMed:16216911, PubMed:23856005, PubMed:26545797, PubMed:27927697, PubMed:8075637). Favors the reduction of androstenedione to testosterone (PubMed:16216911, PubMed:23856005, PubMed:26545797, PubMed:27927697). Testosterone is the key androgen driving male development and function (PubMed:8075637). Uses NADPH while the two other EDH17B enzymes use NADH (PubMed:16216911, PubMed:26545797, PubMed:8075637). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17 (PubMed:16216911). Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed:16216911, PubMed:27927697)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Lessons from 17beta-HSD3 deficiency: Clinical spectrum and complex molecular basis in Chinese patients., [RefSeq, PubMed]; Molecular mechanisms underlying the defects of two novel mutations in the HSD17B3 gene found in the Tunisian population., [RefSeq, PubMed]; Substituted Aryl Benzylamines as Potent and Selective Inhibitors of 17beta-Hydroxysteroid Dehydrogenase Type 3. Publication Status: Online-Only, [RefSeq, PubMed]; The novel founder homozygous V225M mutation in the HSD17B3 gene causes aberrant splicing and XY-DSD., [RefSeq, PubMed]; This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone.  It preferentially uses NADP as cofactor.  Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5U0Q6",
        "ec_number_list": "1.1.1.300;1.1.1.-;1.1.1.64;1.1.1.54;1.1.1.216;1.1.1.62;1.1.1.239;1.1.1.105;1.1.1.209;1.1.1.53;1.1.1.51;1.1.1.225;1.1.1.357;1.1.1.210;1.1.1.188;1.3.1.3;1.1.1.112;1.3.1.20;1.1.1.270;1.1.1.149;1.1.1.330",
        "go_molecular_function": "GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0047045 testosterone dehydrogenase (NADP+) activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0006702 androgen biosynthetic process;GO:0061370 testosterone biosynthetic process;GO:0030539 male genitalia development",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "P37058-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P51397-1",
        "uniprot_id": "DAP1_HUMAN",
        "mass": 11165.0,
        "length": 102,
        "protein_name": "Death-associated protein 1",
        "gene_name": "DAP",
        "organism": "Human",
        "refseq_name": "death-associated protein 1 isoform 1",
        "refseq_ac": "NP_001278892",
        "gene_names_uniprotkb": "DAP; DAP1",
        "gene_names_refseq": "DAP1; DAP",
        "protein_names_uniprotkb": "Death-associated protein 1; DAP-1",
        "protein_names_refseq": "DAP-1; death-associated protein 1 isoform 1; death-associated protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1611)",
        "pathway_count": 1,
        "publication_count": 28,
        "publication_id_list": "16602700;17081983;17287340;17322306;18669648;19413330;19651622;20068231;20537536;21406692;24270644;25530065;25576301;27846572;29242379;29393594;29557506;31848261;33263927;33298915;33592498;33952460;33968037;35051231;35580925;36284347;38665916;7828849",
        "class_list": "",
        "function": "Backbone and nearly complete side-chain chemical shift assignments of the human death-associated protein 1 (DAP1)., [RefSeq, PubMed]; DAP1 may have an important role in cell adhesion, migration and growth in the context of breast cancer and has significant associations with the apoptosis pathway., [RefSeq, PubMed]; DAP1 was found to be correlated with disease progression and long-term survival of the colorectal patients. DAP1 is also a pivotal regulator of the growth and apoptosis and cellular response to chemotherapy agents., [RefSeq, PubMed]; Expression of Death Associated Proteins DAP1 and DAP3 in Human Pancreatic Cancer., [RefSeq, PubMed]; Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (By similarity). Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy (PubMed:20537536). Involved in mediating interferon-gamma-induced cell death (PubMed:7828849)., [UniProtKB, PubMed, UniProtKB, PubMed]; This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6FGC3;Q9BUC9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0043022 ribosome binding",
        "go_cellular_component": "",
        "go_biological_process": "GO:0006915 apoptotic process;GO:0097190 apoptotic signaling pathway;GO:0006914 autophagy;GO:0010507 negative regulation of autophagy;GO:0141014 ribosome hibernation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "P51397-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q07507-1",
        "uniprot_id": "DERM_HUMAN",
        "mass": 24005.0,
        "length": 201,
        "protein_name": "Dermatopontin",
        "gene_name": "DPT",
        "organism": "Human",
        "refseq_name": "dermatopontin precursor",
        "refseq_ac": "NP_001928",
        "gene_names_uniprotkb": "DPT",
        "gene_names_refseq": "DPT; TRAMP",
        "protein_names_uniprotkb": "Dermatopontin; TRAMP; Tyrosine-rich acidic matrix protein",
        "protein_names_refseq": "dermatopontin precursor; tyrosine-rich acidic matrix protein",
        "tax_id": 9606,
        "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)",
        "pathway": " (hsa:1805)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "10233760;17547532;25576301;27726376;29485866;29557506;29786170;29789417;30429286;31154438;31848261;32157095;34185709;35580925;36193505;36774339;37556876;38300311;39148085;8104875",
        "class_list": "",
        "function": "A Potential Four-Gene Signature and Nomogram for Predicting the Overall Survival of Papillary Thyroid Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Clinical importance and PI3K/Akt pathway-dependent anti-proliferative role of PALMD and DPT in breast cancer., [RefSeq, PubMed]; DNMT3a-dermatopontin axis suppresses breast cancer malignancy via inactivating YAP. Publication Status: Online-Only, [RefSeq, PubMed]; Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008]., [RefSeq]; Downregulation of dermatopontin in cholangiocarcinoma cells suppresses CCL19 secretion of macrophages and immune infiltration. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of HTRA1, DPT and MXRA5 as potential biomarkers associated with osteoarthritis progression and immune infiltration. Publication Status: Online-Only, [RefSeq, PubMed]; Roles of dermatopontin and histamine receptor H1 genes as downstream targets for the VDR were confirmed by gel electromotility shift and chromatin immunoprecipitation assays that showed the presence of VDR complex binding sequences, [RefSeq, PubMed]; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K981;Q8N4R2;Q9UIX8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005201 extracellular matrix structural constituent",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0030199 collagen fibril organization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q07507-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5KSL6-1",
        "uniprot_id": "DGKK_HUMAN",
        "mass": 141829.0,
        "length": 1271,
        "protein_name": "Diacylglycerol kinase kappa",
        "gene_name": "DGKK",
        "organism": "Human",
        "refseq_name": "diacylglycerol kinase kappa",
        "refseq_ac": "NP_001013764",
        "gene_names_uniprotkb": "DGKK",
        "gene_names_refseq": "DGKK",
        "protein_names_uniprotkb": "Diacylglycerol kinase kappa; 142 kDa diacylglycerol kinase; 2.7.1.107; DAG kinase kappa; DGK-kappa; Diglyceride kinase kappa",
        "protein_names_refseq": "142 kDa diacylglycerol kinase; DAG kinase kappa; DGK-kappa; diacylglycerol kinase kappa; diglyceride kinase kappa",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:139189);  (R-HSA-114508)",
        "pathway_count": 2,
        "publication_count": 22,
        "publication_id_list": "11080611;11413485;11805119;16210324;18491316;19033211;19413330;20068231;21113153;2175712;23949095;25327554;28597849;29464676;29557506;30379171;31102501;32488085;35051231;36241641;9601053;9930701",
        "class_list": "",
        "function": "Common variants in DGKK are strongly associated with risk of hypospadias Erratum:[Nat Genet. 2011 Mar;43(3):277], [RefSeq, PubMed]; DGK kappa is a novel human type II diacylglycerol kinase, [RefSeq, PubMed]; Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:16210324, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable)., [UniProtKB, PubMed, PubMed]; Five DGKK variants previously reported as associated with hypospadias were identified in the genotype data. None of the variants were associated with second- or third-degree hypospadias (range of odds ratios = 0.7-0.9, all p > .05).  None of the variants were associated with second- or third-degree hypospadias (range of odds ratios = 0.7-0.9, all p > .05)., [RefSeq, PubMed]; Our study provides strong evidence of an association between DGKK nucleotide variants, haplotypes and hypospadias susceptibility. Publication Status: Online-Only, [RefSeq, PubMed]; Studied the relationship between DGKK single nucleotide polymorphisms (SNPs) and hypospadias risk in the Han Chinese population., [RefSeq, PubMed]; The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]., [RefSeq]; This study successfully implicated DGKK variants in hypospadias risk among a Han Chinese population, especially for mild/moderate cases. Severe forms of hypospadias are likely due to other genetic factors, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RP91",
        "ec_number_list": "2.7.1.107;2.7.1.93;2.7.1.94;2.7.1.138",
        "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0006979 response to oxidative stress;GO:0035556 intracellular signal transduction;GO:0030168 platelet activation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q5KSL6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q68D51-1",
        "uniprot_id": "DEN2C_HUMAN",
        "mass": 106865.0,
        "length": 928,
        "protein_name": "DENN domain-containing protein 2C",
        "gene_name": "DENND2C",
        "organism": "Human",
        "refseq_name": "DENN domain-containing protein 2C isoform 1",
        "refseq_ac": "NP_001243333",
        "gene_names_uniprotkb": "DENND2C",
        "gene_names_refseq": "DENND2C; dJ1156J9.1",
        "protein_names_uniprotkb": "DENN domain-containing protein 2C",
        "protein_names_refseq": "DENN domain-containing protein 2C isoform 1; DENN domain-containing protein 2C; DENN/MADD domain containing 2C; RP5-1156J9.1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:163259);  (R-HSA-8876198)",
        "pathway_count": 2,
        "publication_count": 193,
        "publication_id_list": "10818110;10990452;11038176;11179213;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18701652;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19620288;19656848;19725050;19729655;19745841;20008558;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23645161;23678941;23684622;23713133;23839779;24296415;24644286;24694596;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25472813;25648148;25713415;25925668;26055712;26177209;26245486;26434594;26538022;26925400;26936971;27041585;27044746;27103185;27246931;27329675;28832583;28834231;28904123;29237092;29557506;30429286;30620550;31530632;32387766;32938616;32983136;35051231;7688123;7911226;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AL26;Q5TCX6;Q6P3R3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 19.7,
        "record_id": "Q68D51-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZPD8-1",
        "uniprot_id": "DG2L6_HUMAN",
        "mass": 38593.0,
        "length": 337,
        "protein_name": "Diacylglycerol O-acyltransferase 2-like protein 6",
        "gene_name": "DGAT2L6",
        "organism": "Human",
        "refseq_name": "diacylglycerol O-acyltransferase 2-like protein 6",
        "refseq_ac": "NP_940914",
        "gene_names_uniprotkb": "DGAT2L6; DC3",
        "gene_names_refseq": "DC3; DGAT2L6",
        "protein_names_uniprotkb": "Diacylglycerol O-acyltransferase 2-like protein 6; 2.3.1.-; Diacylglycerol O-acyltransferase candidate 3; hDC3",
        "protein_names_refseq": "diacylglycerol O-acyltransferase 2-like protein 6; diacylglycerol O-acyltransferase candidate 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:347516);  (R-HSA-1482883)",
        "pathway_count": 2,
        "publication_count": 17,
        "publication_id_list": "11481335;14521909;14970677;15272052;15364929;15671038;16106050;18452279;19957260;19962385;20034933;21068004;28420705;29351928;31092671;39894887;9756920",
        "class_list": "",
        "function": "Diglyceride acyltransferase that uses fatty acyl-CoA as substrate (PubMed:15671038). Particularly active with oleate as a substrate (PubMed:15671038). Has no wax synthase activity to produce wax esters (PubMed:15671038). Able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705)., [UniProtKB, PubMed, PubMed]; This gene is a member of the diacylglycerol acyltransferase 2 family. The encoded protein is a putative acyltransferase and is most likely involved in the synthesis of di- or triacylglycerol, however its substrate specificity is currently unknown. [provided by RefSeq, Feb 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IEE2",
        "ec_number_list": "2.3.1.20;2.3.1.76;2.3.1.22;2.3.1.75;2.3.1.-",
        "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0008374 O-acyltransferase activity",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0036155 acylglycerol acyl-chain remodeling;GO:0006640 monoacylglycerol biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q6ZPD8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86TM3-1",
        "uniprot_id": "DDX53_HUMAN",
        "mass": 71154.0,
        "length": 631,
        "protein_name": "Probable ATP-dependent RNA helicase DDX53",
        "gene_name": "DDX53",
        "organism": "Human",
        "refseq_name": "DEAD box protein 53",
        "refseq_ac": "NP_874358",
        "gene_names_uniprotkb": "DDX53; CAGE",
        "gene_names_refseq": "CAGE; CT26; DDX53",
        "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX53; 3.6.4.13; CT26; Cancer-associated gene protein; Cancer/testis antigen 26; DEAD box protein 53; DEAD box protein CAGE",
        "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 53; DEAD box protein 53; DEAD-box protein CAGE; cancer-associated gene protein; cancer/testis antigen 26; probable ATP-dependent RNA helicase DDX53",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:168400)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11922625;12849980;17028776;17341616;18388483;18452278;19615748;20941364;21248752;28535666;30315122;30454700;30484775;31844290;32387766;32938616;33141586;33298915;34211107;34405274;35051231;36635662;37217939",
        "class_list": "",
        "function": "A novel role of DDX53 in regulating cancer stem cell-like properties by binding to SOX-2.DDX53 directly regulates the SOX-2 expression in drug-resistant melanoma cells., [RefSeq, PubMed]; CAGE is expressed in a variety of cancers but not in normal tissues except testis, and might play a role in cellular proliferation., [RefSeq, PubMed]; CAGE promotes motility of cancer cells through activation of focal adhesion kinase (FAK)., [RefSeq, PubMed]; DDX53 plays a critical role in taxol-resistance by activating autophagy and a potential therapeutic target for the treatment of taxol-resistant cervix cancer., [RefSeq, PubMed]; Disruption of DDX53 coding sequence has limited impact on iPSC-derived human NGN2 neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Hypomethylated CAGE promoter CpG islands are frequently involved in uterine cervical carcinogenesis., [RefSeq, PubMed]; Results suggest that the methylation status of the CpG sites of CAGE determines its expression, and that hypomethylation of CAGE precedes the development of gastric cancer and hepatocellular carcinoma, [RefSeq, PubMed]; The CAGE gene is widely expressed in various cancer tissues and cancer cell lines., [RefSeq, PubMed]; This intronless gene encodes a protein which contains several domains found in members of the DEAD-box helicase protein family. Other members of this protein family participate in ATP-dependent RNA unwinding. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0D2N2;Q6NVV4",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q86TM3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N2C3-1",
        "uniprot_id": "DEPD4_HUMAN",
        "mass": 33694.0,
        "length": 294,
        "protein_name": "DEP domain-containing protein 4",
        "gene_name": "DEPDC4",
        "organism": "Human",
        "refseq_name": "DEP domain-containing protein 4 isoform 2",
        "refseq_ac": "NP_001306239",
        "gene_names_uniprotkb": "DEPDC4",
        "gene_names_refseq": "DEP.4; DEPDC4",
        "protein_names_uniprotkb": "DEP domain-containing protein 4",
        "protein_names_refseq": "DEP domain-containing protein 4 isoform 2; DEP domain-containing protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:120863)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;31844290;33298915",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q496C8;Q96BW0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0035556 intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q8N2C3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N687-1",
        "uniprot_id": "DB125_HUMAN",
        "mass": 17537.0,
        "length": 156,
        "protein_name": "Beta-defensin 125",
        "gene_name": "DEFB125",
        "organism": "Human",
        "refseq_name": "beta-defensin 125 preproprotein",
        "refseq_ac": "NP_697020",
        "gene_names_uniprotkb": "DEFB125; DEFB25",
        "gene_names_refseq": "DEFB-25; DEFB125",
        "protein_names_uniprotkb": "Beta-defensin 125; Beta-defensin 25; DEFB-25; Defensin, beta 125",
        "protein_names_refseq": "beta defensin 25; beta-defensin 125 preproprotein; beta-defensin 125",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:245938);  (R-HSA-1461957);  (R-HSA-1461973)",
        "pathway_count": 3,
        "publication_count": 14,
        "publication_id_list": "10521347;10914484;11085990;11702237;11854508;11934878;12620395;12949495;18006661;20214904;20385753;20483750;21122132;9541493",
        "class_list": "",
        "function": "Defensins are cysteine-rich cationic polypeptides that are important in the host immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]., [RefSeq]; Has antibacterial activity., [UniProtKB]; The protein encoded by this gene is thought to display antimicrobial activity., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A502;Q7Z7B9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0140912 membrane destabilizing activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0031640 killing of cells of another organism",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q8N687-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WVC6-1",
        "uniprot_id": "DCAKD_HUMAN",
        "mass": 26550.0,
        "length": 231,
        "protein_name": "Dephospho-CoA kinase domain-containing protein",
        "gene_name": "DCAKD",
        "organism": "Human",
        "refseq_name": "dephospho-CoA kinase domain-containing protein",
        "refseq_ac": "NP_001122103",
        "gene_names_uniprotkb": "DCAKD",
        "gene_names_refseq": "DCAKD",
        "protein_names_uniprotkb": "Dephospho-CoA kinase domain-containing protein",
        "protein_names_refseq": "dephospho-CoA kinase domain-containing protein",
        "tax_id": 9606,
        "disease": "neurodegeneration with brain iron accumulation 6 (Disease Ontology:DOID:0110740)",
        "pathway": " (hsa:79877);  (R-HSA-196783)",
        "pathway_count": 2,
        "publication_count": 61,
        "publication_id_list": "11237011;11479594;11923312;11994049;12095677;12554685;12906824;14514684;14523052;15105273;15581364;15893380;16040613;16272150;17242360;20112406;20877624;23481700;25418920;25880248;25892735;26811146;26992070;27600516;28063628;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29632046;29769354;30410026;30484775;31217245;31530632;31844290;31848261;32157095;32161166;32265295;32357974;32387766;32502341;32938616;32983136;33592498;33717175;33912179;33968037;34357683;35051231;35318648;35580925;36010968;36215666;36241641;36983025",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3Z0;D3DX60;D3DX62;Q9BR71;Q9H5W1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004140 dephospho-CoA kinase activity;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0015937 coenzyme A biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q8WVC6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96PH6-1",
        "uniprot_id": "DB118_HUMAN",
        "mass": 13614.0,
        "length": 123,
        "protein_name": "Defensin beta 118",
        "gene_name": "DEFB118",
        "organism": "Human",
        "refseq_name": "defensin beta 118 precursor",
        "refseq_ac": "NP_473453",
        "gene_names_uniprotkb": "DEFB118; C20orf63; DEFB18; ESC42",
        "gene_names_refseq": "C20orf63; DEFB-18; DEFB118; ESC42; ESP13.6",
        "protein_names_uniprotkb": "Defensin beta 118; Beta-defensin 18; DEFB-18; ESP13.6; Epididymal secretory protein 13.6",
        "protein_names_refseq": "defensin beta 118 precursor; defensin, beta 18; epididymal secretory protein 13.6; epididymis secretory sperm binding protein; epididymus specific clone 42",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:117285);  (R-HSA-1461957);  (R-HSA-1461973)",
        "pathway_count": 3,
        "publication_count": 20,
        "publication_id_list": "10521347;10914484;11085990;11564719;11702237;11854508;11934878;12600824;12949495;15033915;18006661;20214904;20385753;20483750;21122132;28411811;33181266;33224970;33630763;9541493",
        "class_list": "",
        "function": "DEFB118 may contribute to epididymal innate immunity and provide antimicrobial activity against microorganisms attacking sperm in the male and female reproductive tracts., [RefSeq, PubMed]; Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis (PubMed:15033915, PubMed:33224970). Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes (PubMed:33224970). Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface (PubMed:15033915). Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization (PubMed:33181266). May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms (PubMed:15033915)., [UniProtKB, PubMed, PubMed, PubMed]; The truncated human beta-defensin 118 can modulate lipopolysaccharide mediated inflammatory response in RAW264.7 macrophages., [RefSeq, PubMed]; This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. Expression of this gene is regulated by androgen, and the encoded protein binds to sperm and exhibits antibacterial activity against E. coli. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. [provided by RefSeq, Nov 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q17RC4;Q8N691;Q9NUH0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0140912 membrane destabilizing activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0007283 spermatogenesis;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q96PH6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96QD5-1",
        "uniprot_id": "DEPD7_HUMAN",
        "mass": 58310.0,
        "length": 511,
        "protein_name": "DEP domain-containing protein 7",
        "gene_name": "DEPDC7",
        "organism": "Human",
        "refseq_name": "DEP domain-containing protein 7 isoform 1",
        "refseq_ac": "NP_001070710",
        "gene_names_uniprotkb": "DEPDC7",
        "gene_names_refseq": "DEPDC7; TR2; dJ85M6.4",
        "protein_names_uniprotkb": "DEP domain-containing protein 7; Protein TR2/D15",
        "protein_names_refseq": "DEP domain-containing protein 7 isoform 1; DEP domain-containing protein 7; dJ85M6.4 (novel 58.3 KDA protein); novel 58.3 KDA protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91614)",
        "pathway_count": 1,
        "publication_count": 35,
        "publication_id_list": "10568747;18669648;23481700;25541973;25952135;26992070;27016254;28832583;28834231;29242379;30429286;30484775;30779550;30833945;31154438;31844290;31848261;32157095;32161166;32387766;32488085;32897882;32938616;33968037;34171305;34509645;34932366;35051231;35580925;36010968;36215666;36241641;36284347;38253038;40596516",
        "class_list": "",
        "function": "DEPDC7 hypomethylation in peripheral blood DNA may be associated with recent depressive symptomatology., [RefSeq, PubMed]; RNA interference (RNAi) recombinant lentiviral vector particle targeting DEPDC7 was constructed in order to knockdown its gene expression in human hepatocellular carcinoma cell line HepG2., [RefSeq, PubMed]; The study identified the DEP domain-containing protein DEPDC7 as cellular binding partner of CARMA2 and CARMA3 proteins. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G5E941;Q8N602;Q8NCU9;Q9UGK5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0035556 intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "Q96QD5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BSY9-1",
        "uniprot_id": "DESI2_HUMAN",
        "mass": 21444.0,
        "length": 194,
        "protein_name": "Deubiquitinase DESI2",
        "gene_name": "DESI2",
        "organism": "Human",
        "refseq_name": "deubiquitinase DESI2 isoform 2",
        "refseq_ac": "NP_001284675",
        "gene_names_uniprotkb": "DESI2; C1orf121; CGI-146; FAM152A; PNAS-4; PPPDE1",
        "gene_names_refseq": "C1orf121; CGI-146; DESI2; DeSI-2; FAM152A; PNAS-4; PPPDE1",
        "protein_names_uniprotkb": "Deubiquitinase DESI2; 3.1.2.22; 3.4.19.12; DeSI-2; Desumoylating isopeptidase 2; PPPDE peptidase domain-containing protein 1; Palmitoyl protein thioesterase DESI2; Protein FAM152A; S-depalmitoylase DESI2",
        "protein_names_refseq": "PPPDE peptidase domain-containing protein 1; S-depalmitoylase DESI2; deubiquitinase DESI2 isoform 2; deubiquitinase DESI2; family with sequence similarity 152, member A; palmitoyl protein thioesterase DESI2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51029)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "11237011;19133312;21556770;23322088;23481700;25576301;25892735;26992070;28483520;28514659;28904123;29769354;29786170;30055135;30315122;30411297;30426280;31217245;31844290;32157095;32387766;32502341;32938616;33717175;33912179;33936100;33968037;35051231;35251023;35427157;36215666;36241641",
        "class_list": "",
        "function": "Combination of DESI2 and endostatin gene therapy in the mouse models significantly improves antitumor efficacy by accumulating DNA lesions, inducing apoptosis and inhibiting angiogenesis., [RefSeq, PubMed]; DESI2 regulates the proliferation and apoptosis of pancreatic cancer cells through PI3K/AKT/mTOR signaling pathway, [RefSeq, PubMed]; HPNAS-4 inhibits proliferation of ovarian cancer cells by inducing S phase arrest and apoptosis via activation of Cdc25A-Cdk2-Cyclin E/Cyclin A axis and mitochondrial dysfunction-mediated caspase-dependent and -independent apoptotic pathways., [RefSeq, PubMed]; Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization (PubMed:28483520). Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5) (PubMed:35427157)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Overexpression of human PNAS4 induced apoptosis and arrested cell cycle in S phase in A549 human lung adenocarcinoma cells., [RefSeq, PubMed]; PNAS-4 is not a p53 target, but overexpression of PNAS-4 is correlated to p53 inactivity in colorectal cancer., [RefSeq, PubMed]; PPPDE1 is a key modulator of p53 protein level and its down stream apoptosis pathway. These results suggested that PPPDE1 is a putative Hepatocellular carcinoma driver gene., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1APK6;Q5VVC6;Q9NYS2;Q9Y3E4",
        "ec_number_list": "3.1.2.22;2.3.1.-;3.1.2.-;3.1.2.2;3.4.-.-;3.4.19.12;3.1.1.93",
        "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q9BSY9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BVC3-1",
        "uniprot_id": "DCC1_HUMAN",
        "mass": 44825.0,
        "length": 393,
        "protein_name": "Sister chromatid cohesion protein DCC1",
        "gene_name": "DSCC1",
        "organism": "Human",
        "refseq_name": "sister chromatid cohesion protein DCC1",
        "refseq_ac": "NP_076999",
        "gene_names_uniprotkb": "DSCC1; DCC1; PRO34008",
        "gene_names_refseq": "DCC1; DSCC1",
        "protein_names_uniprotkb": "Sister chromatid cohesion protein DCC1; Defective in sister chromatid cohesion protein 1 homolog",
        "protein_names_refseq": "defective in sister chromatid cohesion 1 homolog; defective in sister chromatid cohesion protein 1 homolog; sister chromatid cohesion protein DCC1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79075);  (R-HSA-174411)",
        "pathway_count": 2,
        "publication_count": 50,
        "publication_id_list": "10329413;12766176;12930902;12975309;15066120;18499658;1974050;19907496;23481700;24038470;24115439;25418920;25576301;26154972;26811146;27920218;28218747;28832583;28834231;28904123;29242379;29393594;29437277;29632046;30315122;30410026;31530632;31844290;32157095;32265295;32357974;32387766;32488085;32897882;32938616;33141586;33184243;33691108;33968037;34087483;34171305;34211107;34509645;34561969;34932366;35051231;35318648;38678604;8954124;9822671",
        "class_list": "",
        "function": "CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]., [RefSeq]; Characterization of the prognostic, diagnostic, and immunological roles of DSCC1 and its genomic alteration and instability in human cancers. Publication Status: Online-Only, [RefSeq, PubMed]; DNA replication and sister chromatid cohesion 1 promotes breast carcinoma progression by modulating the Wnt/beta-catenin signaling and p53 protein., [RefSeq, PubMed]; HCTF18, hCTF8, and hDCC1 interact with each other as well as with the p38 subunit of RFC, [RefSeq, PubMed]; Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3., [UniProtKB, PubMed, PubMed]; The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q969N5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0031390 Ctf18 RFC-like complex",
        "go_biological_process": "GO:0006260 DNA replication;GO:0006275 regulation of DNA replication;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0034088 maintenance of mitotic sister chromatid cohesion;GO:0034421 post-translational protein acetylation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q9BVC3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H6A0-1",
        "uniprot_id": "DEN2D_HUMAN",
        "mass": 53672.0,
        "length": 471,
        "protein_name": "DENN domain-containing protein 2D",
        "gene_name": "DENND2D",
        "organism": "Human",
        "refseq_name": "DENN domain-containing protein 2D isoform b",
        "refseq_ac": "NP_001258762",
        "gene_names_uniprotkb": "DENND2D",
        "gene_names_refseq": "DENND2D",
        "protein_names_uniprotkb": "DENN domain-containing protein 2D",
        "protein_names_refseq": "DENN domain-containing protein 2D isoform b; DENN domain-containing protein 2D; DENN/MADD domain containing 2D; RP5-1180E21.2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79961);  (R-HSA-8876198)",
        "pathway_count": 2,
        "publication_count": 213,
        "publication_id_list": "10818110;10990452;11038176;11179213;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18677770;18701652;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19620288;19656848;19725050;19729655;19745841;20008558;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22424782;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23182661;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23645161;23678941;23684622;23713133;23839779;24189587;24296415;24317529;24366607;24644286;24694596;24695972;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25472813;25648148;25713415;25925668;26055712;26154972;26177209;26245486;26434594;26538022;26925400;26936971;26992070;27041585;27044746;27103185;27246931;27329675;27846572;27862975;27929118;28904123;29437277;29557506;30410026;31217245;31844290;32157095;32350084;32357974;32387766;32502341;32983136;33298915;33717175;33912179;34185709;34509645;34932366;35051231;35580925;7688123;7911226;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "DENND2D is a candidate tumor suppressor gene that is inactivated by promoter hypermethylation in patients with Hepatocellular carcinoma and may serve as a novel biomarker of early recurrence of Hepatocellular carcinoma ., [RefSeq, PubMed]; DENND2D is a candidate tumor suppressor gene that was inactivated by promoter hypermethylation in patients with esophageal squamous cell carcinoma and may serve as a novel biomarker of esophageal squamous cell carcinoma., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form., [UniProtKB, PubMed]; Higher frequency of promoter hypermethylation of DENND2D is associated with gastric cancer., [RefSeq, PubMed]; Mutations in DENND2D in melanoma by inhibition of nonsense-mediated mRNA decay., [RefSeq, PubMed]; Our data show that DENND2D might function as a tumor suppressor-like gene, preventing survival and expansion of cells with genetic damage through apoptosis mechanism. Absence of DENND2D might play a permissive role, as an early event, in tumorigenesis., [RefSeq, PubMed]; Resulted in increased cell motility and invasive ability. Moreover, miR-1246 increased cell motility by directly targeting DENN/MADD Domain Containing 2D (DENND2D) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T5V6;Q9BSU0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 21.4,
        "record_id": "Q9H6A0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H8H2-1",
        "uniprot_id": "DDX31_HUMAN",
        "mass": 94087.0,
        "length": 851,
        "protein_name": "ATP-dependent DNA helicase DDX31",
        "gene_name": "DDX31",
        "organism": "Human",
        "refseq_name": "ATP-dependent DNA helicase DDX31 isoform 7",
        "refseq_ac": "NP_001309273",
        "gene_names_uniprotkb": "DDX31",
        "gene_names_refseq": "DDX31; PPP1R25",
        "protein_names_uniprotkb": "ATP-dependent DNA helicase DDX31; 3.6.4.13; 5.6.2.-; DEAD box protein 31; Helicain; Probable ATP-dependent RNA helicase DDX31",
        "protein_names_refseq": "ATP-dependent DNA helicase DDX31 isoform 7; ATP-dependent DNA helicase DDX31; DEAD (Asp-Glu-Ala-Asp) box polypeptide 31; DEAD box protein 31; DEAD/DEXH helicase DDX31; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31; G2 helicase; helicain; probable ATP-dependent RNA helicase DDX31; protein phosphatase 1, regulatory subunit 25",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64794)",
        "pathway_count": 1,
        "publication_count": 57,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12429849;12782131;23019224;23481700;24129315;24397554;24715725;25418920;25576301;26154972;26811146;26992070;27846572;28649982;28832583;28904123;29242379;29393594;29440146;29557506;29786170;30315122;30410026;30779550;31154438;31217245;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32897882;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34509645;34561969;34932366;35051231;35251023;35580925;36010968;36241641",
        "class_list": "",
        "function": "DDX31 cooperates with mutp53 and EGFR to promote progression of muscle invasive bladder cancer., [RefSeq, PubMed]; DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2016]., [RefSeq]; Findings define a mechanism through which control of the DDX31-NPM1 complex is likely to play critical roles in renal carcinogenesis., [RefSeq, PubMed]; May have DNA helicase activity and RNA helicase activity. Probably have ssDNA and RNA dependent ATPase activity (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (PubMed:23019224)., [UniProtKB, PubMed, UniProtKB]; RNA helicase., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5K6N2;Q5K6N3;Q5K6N4;Q5VZJ4;Q5VZJ9;Q96E91;Q96NY2;Q96SX5;Q9H5K6",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus",
        "go_biological_process": "GO:0042254 ribosome biogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "Q9H8H2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NS23-1",
        "uniprot_id": "RASF1_HUMAN",
        "mass": 39219.0,
        "length": 344,
        "protein_name": "Ras association domain-containing protein 1",
        "gene_name": "RASSF1",
        "organism": "Human",
        "refseq_name": "ras association domain-containing protein 1 isoform B",
        "refseq_ac": "NP_001193886",
        "gene_names_uniprotkb": "RASSF1; RDA32",
        "gene_names_refseq": "123F2; NORE2A; RASSF1A; RASSF1; RDA32; REH3P21",
        "protein_names_uniprotkb": "Ras association domain-containing protein 1",
        "protein_names_refseq": "Ras association (RalGDS/AF-6) domain family member 1; WUGSC:H_LUCA12.5; cardiac-specific ras association domain family 1 protein; pancreas-specific ras association domain family 1 protein; ras association domain-containing protein 1 isoform B; ras association domain-containing protein 1; tumor suppressor protein RDA32",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450)",
        "pathway": " (hsa:11186)",
        "pathway_count": 1,
        "publication_count": 86,
        "publication_id_list": "10608806;10888881;11333291;11857081;12024041;14729613;14743218;15109305;15205320;15753381;15949439;16510573;17563743;18071316;18566590;18691976;19276349;19369195;19962312;21134643;21199877;23481700;24129315;24197116;24714562;24715725;25576301;25645385;26154972;26375851;26728094;26992070;27600516;27846572;27862975;28218747;28228285;28832583;28834231;28904123;29242379;29493099;29508533;29557506;29632711;29786170;30315122;30429286;30524438;30833945;31154438;31222486;31844290;31848261;31998317;32157095;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33537174;33592498;33691108;33717175;33936100;33968037;34171305;34185709;34509645;34932366;35051231;35561310;35580925;36010968;37938771;38093706;38115290;38203733;38493315;38840077",
        "class_list": "",
        "function": "Association of the SHOX2 and RASSF1A methylation levels with the pathological evolution of early-stage lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Diagnostic Value of GSTP1, RASSF1, AND RASSF2 Methylation in Serum of Prostate Cancer Patients. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of RASSF1A, DIRAS3, and AKAP9 Genes in Thyroid Lesions: Implications for Differential Diagnosis and Prognosis of Thyroid Carcinomas. Publication Status: Online-Only, [RefSeq, PubMed]; Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; RASSF1A promotes ATM signaling and RASSF1A methylation is a synthetic lethal marker for ATR inhibitors., [RefSeq, PubMed]; SEPT9, H4C6, and RASSF1A methylation in nasopharyngeal swabs: A reflection of potential minimally invasive biomarkers for early screening of nasopharyngeal cancer., [RefSeq, PubMed]; This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 9,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZLL1;O14571;O60539;O60710;Q0VGC6;Q5TZT2;Q9HB04;Q9HB18;Q9NS22;Q9UND4;Q9UND5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton",
        "go_biological_process": "GO:0006974 DNA damage response;GO:0007265 Ras protein signal transduction;GO:0050821 protein stabilization;GO:0031398 positive regulation of protein ubiquitination;GO:1902806 regulation of cell cycle G1/S phase transition",
        "synthesized_glycan_count": 0,
        "hit_score": 8.7,
        "record_id": "Q9NS23-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NSV4-3",
        "uniprot_id": "DIAP3_HUMAN",
        "mass": 136926.0,
        "length": 1193,
        "protein_name": "Protein diaphanous homolog 3",
        "gene_name": "DIAPH3",
        "organism": "Human",
        "refseq_name": "protein diaphanous homolog 3 isoform a",
        "refseq_ac": "NP_001035982",
        "gene_names_uniprotkb": "DIAPH3; DIAP3",
        "gene_names_refseq": "AN; AUNA1; DIA2; DIAPH3; DRF3; NSDAN; diap3; mDia2",
        "protein_names_uniprotkb": "Protein diaphanous homolog 3; DRF3; Diaphanous-related formin-3; MDia2",
        "protein_names_refseq": "diaphanous homolog 3; protein diaphanous homolog 3 isoform a",
        "tax_id": 9606,
        "disease": "autosomal dominant auditory neuropathy 1 (Disease Ontology:DOID:0060690); microcephaly (Disease Ontology:DOID:10907); congenital dyserythropoietic anemia (Disease Ontology:DOID:1338)",
        "pathway": " (hsa:81624);  (R-HSA-5663220);  (R-HSA-8980692);  (R-HSA-9013026);  (R-HSA-9013106);  (R-HSA-9013148);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013405);  (R-HSA-9013406);  (R-HSA-9013408);  (R-HSA-9013409);  (R-HSA-9013423);  (R-HSA-9035034)",
        "pathway_count": 14,
        "publication_count": 508,
        "publication_id_list": "10.1101/2023.09.13.557529;10037681;10232922;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10600384;10618392;10619026;10652265;10678165;10699171;10699464;10724160;10847683;10873388;10873802;10958683;10967094;11007481;11058585;11085924;11145705;11149925;11185749;11207612;11306516;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11680691;11689693;11696321;11704860;11707441;11756552;11773441;11784792;11803464;11804587;11804589;11804590;11864571;11884391;11912491;11919634;11948177;11956649;11961559;11967128;12071859;12093360;12096337;12172552;12177196;12195014;12221077;12221096;12242347;12351724;12376551;12429848;12432077;12456725;12464619;12473120;12531887;12546821;12547822;12577064;12650940;12665586;12732141;12773384;12805219;12857875;12860998;12877655;12907671;12923183;14506234;14512443;14514689;1464587;14675773;14718541;15006353;15023524;15033976;15064355;15085137;15107133;15133129;15147912;15157669;15169870;15260990;15302923;15304341;15339924;15342493;15485661;15507211;15507212;15542837;15546864;15579468;15601624;15611138;15710388;15728722;15814684;15850391;15858067;15864301;15866170;15897194;15944396;16002401;16081809;16112081;16116428;16184169;16217026;16243035;16243036;16292343;16339170;16439214;16467373;16473593;16492808;16507994;16519628;1660188;16622419;16622420;16630611;16636067;16702231;16714282;16762923;16776779;16777452;16777849;16862148;16896804;16914516;16917499;16943183;16968698;17027967;17030981;17060455;17064668;17077126;17129783;17145773;17158234;17196961;17198702;17214551;17244649;17269730;17322306;1737036;17562871;17583407;17599059;17698854;17702745;17765681;17804252;17916560;17932950;17942708;17976533;18001770;18006505;18045877;18056264;18097444;18158243;18191593;18218625;18249095;18347018;18363964;18396277;18426980;18653540;18662984;18697831;18755006;18786931;18802007;18829452;18835169;18838382;18923426;18929667;19258391;19269969;19350017;19457867;19494238;19534724;19581409;19605563;19635168;19651622;19673492;19713215;19815554;19934221;20030946;20068231;20101212;20112406;20233848;20400958;20460433;20591975;20624953;20628200;20660154;20679435;20810653;21119010;21148482;21151158;21351730;21373644;21378159;21397845;21454492;21542010;21565175;21576392;21613211;21621533;21685891;21699497;21730051;21757538;21865595;21868368;21936715;21989057;22004470;22094460;22096251;22184005;22275430;22298643;22305756;22407364;22461490;22475431;22571869;22593025;22608513;22665057;22673745;22734669;22790947;22911862;22970203;22971344;22992742;23029280;23087206;23096567;23186163;23200924;23209303;23222643;23255595;23288169;23406282;23434736;23481700;23572525;23707487;23718289;23757206;23801653;23870057;23870313;23940355;24086303;24102721;24128008;24259668;24297911;24335996;24352656;24355937;24397554;24584464;24623723;24659802;24714562;24715725;24859002;24914801;24933155;24960694;24996924;25024229;25211221;25418920;25425145;25428919;25469497;25576301;25645385;25668492;25673874;25678704;25704760;25721503;25746724;25795300;25862245;25963737;26016997;26129894;26154972;26299518;26371245;26375851;26529257;26598554;26628301;26728094;26811146;26887924;26929215;26992070;27096001;27117132;27145964;27216196;27278019;27481945;27555588;27566826;27600516;27713499;27798618;27806292;27846572;27852748;27862975;27920218;27986909;28028151;28063628;28112683;28114311;28196833;28218747;28228285;28356423;28486133;28514659;28584191;28825699;28832583;28834231;28860189;28860633;28904123;28947137;29089502;29146911;29237092;29242379;29358323;29382922;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29776664;29786170;29789417;30059200;30061681;30192525;30315122;30484775;30853411;31105010;31217245;31389670;31492838;31844290;31871319;32157095;32203420;32265295;32302585;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34509645;34561969;35051231;35254053;35538918;35580925;36010968;36215666;36241641;36581221;36640348;36750200;37217939;37756562;38613636;7476457;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8107774;8537347;8543060;8571126;8617235;8643598;8645157;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8807639;8810315;8816443;8939998;8945468;8990121;8994827;9013646;9099726;9111050;9113980;9252344;9268338;9305890;9405671;9418861;9438849;9490638;9497316;9535835;9548756;9582072;9649308;9659915;9670022;9705280;9792683;9822598;9822605;9829970;9843499;9846874;9857026;9988689",
        "class_list": "",
        "function": "Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity., [UniProtKB, UniProtKB]; CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis and inflammation through miR-338-3p/SRSF1 axis., [RefSeq, PubMed]; DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling., [RefSeq, PubMed]; DIAPH3 is a prognostic biomarker and inhibit colorectal cancer progression through maintaining EGFR degradation., [RefSeq, PubMed]; Isoform-selective actin assembly by DIAPH3 exerts specific and differentially regulated functions during cell adhesion and motility., [RefSeq, PubMed]; Super Enhancer-Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis., [RefSeq, PubMed]; The pan-cancer analysis identified DIAPH3 as a diagnostic biomarker of clinical cancer., [RefSeq, PubMed]; These studies further suggest that Rho GTPases significantly influence the activity of mDia family formins in driving cellular membrane remodeling through the regulation of actin dynamics., [RefSeq, PubMed]; This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 1,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A3B8;A2A3B9;A2A3C0;Q18P99;Q18PA0;Q18PA1;Q2KPB6;Q3ZK23;Q5JTP8;Q5T2S7;Q5XKF6;Q6MZF0;Q6NUP0;Q86VS4;Q8NAV4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0045296 cadherin binding;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament",
        "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0030041 actin filament polymerization",
        "synthesized_glycan_count": 0,
        "hit_score": 51.3,
        "record_id": "Q9NSV4-3",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NUL7-1",
        "uniprot_id": "DDX28_HUMAN",
        "mass": 59581.0,
        "length": 540,
        "protein_name": "Probable ATP-dependent RNA helicase DDX28",
        "gene_name": "DDX28",
        "organism": "Human",
        "refseq_name": "probable ATP-dependent RNA helicase DDX28",
        "refseq_ac": "NP_060850",
        "gene_names_uniprotkb": "DDX28; MDDX28",
        "gene_names_refseq": "DDX28; MDDX28",
        "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX28; 3.6.4.13; Mitochondrial DEAD box protein 28",
        "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 28; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 28; mitochondrial DEAD box protein 28; mitochondrial DEAD-box polypeptide 28; probable ATP-dependent RNA helicase DDX28",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55794)",
        "pathway_count": 1,
        "publication_count": 31,
        "publication_id_list": "11350955;12663657;18491316;19691289;23481700;24715725;25683708;25683715;28228285;29242379;29508533;29557506;31844290;31907278;32157095;32387766;32938616;33141586;33298915;33592498;33691108;33936100;33968037;34087483;34211107;34357683;34509645;35051231;35254053;36215666;40596516",
        "class_list": "",
        "function": "DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase. The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the mitochondria and the nucleus. [provided by RefSeq, Jul 2008]., [RefSeq]; Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955)., [UniProtKB, PubMed, PubMed, PubMed]; The authors have identified the DEAD box protein family member DDX28 as an interactor and negative regulator of HIF-2alpha that suppresses HIF-2alpha's ability to activate eIF4E2-directed translation. Publication Status: Online-Only, [RefSeq, PubMed]; Three domains in the N-terminal half of the protein and its RNA binding ability were essential for nucleolar localization as well as transcription-inhibition-dependent localization to nuclear subcompartments and two were the nuclear localization signal, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0019843 rRNA binding;GO:0003724 RNA helicase activity",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0035770 ribonucleoprotein granule",
        "go_biological_process": "GO:1902775 mitochondrial large ribosomal subunit assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q9NUL7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NXF7-1",
        "uniprot_id": "DCA16_HUMAN",
        "mass": 24193.0,
        "length": 216,
        "protein_name": "DDB1- and CUL4-associated factor 16",
        "gene_name": "DCAF16",
        "organism": "Human",
        "refseq_name": "DDB1- and CUL4-associated factor 16",
        "refseq_ac": "NP_001332809",
        "gene_names_uniprotkb": "DCAF16; C4orf30",
        "gene_names_refseq": "C4orf30; DCAF16",
        "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 16",
        "protein_names_refseq": "DDB1- and CUL4-associated factor 16",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54876);  (R-HSA-8951664)",
        "pathway_count": 2,
        "publication_count": 145,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11069780;11259415;11292861;11292862;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12682069;12759363;12816948;14690597;14757770;15282312;15361859;15367669;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16647857;16707496;16790436;16943200;16949367;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18775313;18776931;18805092;18826954;18851830;18926707;19250909;19321346;19608861;19617556;19748355;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;22959436;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24366543;24636985;24715725;24793695;24793696;25314029;25349211;25355947;25418920;25531226;25576301;25645385;25892735;26344709;26460955;26632597;26906416;26992070;27030794;27222660;27565346;27600516;28115426;28218747;28832583;29153394;29242379;29437277;30315122;30410026;30524438;30610225;30779550;31209349;31844290;31998317;32005965;32157095;32265295;32284348;32357974;32387766;32897882;32938616;33298915;33444648;33537174;33592498;33968037;33981976;34093574;34171305;34405274;34509645;35430559;36010968;36241641;9790970;9887101;9891082",
        "class_list": "",
        "function": "Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins., [UniProtKB, PubMed, PubMed]; Selective degradation of PARP2 by PROTACs via recruiting DCAF16 for triple-negative breast cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KPB7",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0080008 Cul4-RING E3 ubiquitin ligase complex",
        "go_biological_process": "GO:0016567 protein ubiquitination;GO:0040029 epigenetic regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 14.6,
        "record_id": "Q9NXF7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UBT3-1",
        "uniprot_id": "DKK4_HUMAN",
        "mass": 24876.0,
        "length": 224,
        "protein_name": "Dickkopf-related protein 4",
        "gene_name": "DKK4",
        "organism": "Human",
        "refseq_name": "dickkopf-related protein 4 precursor",
        "refseq_ac": "NP_055235",
        "gene_names_uniprotkb": "DKK4",
        "gene_names_refseq": "DKK-4; DKK4",
        "protein_names_uniprotkb": "Dickkopf-related protein 4; Dickkopf-4; Dkk-4; hDkk-4",
        "protein_names_refseq": "dickkopf-4; dickkopf-related protein 4 precursor; dickkopf-related protein 4; hDkk-4",
        "tax_id": 9606,
        "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); obstructive sleep apnea (Disease Ontology:DOID:0050848); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); acute asthma (Disease Ontology:DOID:0080810); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); paracoccidioidomycosis (Disease Ontology:DOID:12662); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); pulmonary hypertension (Disease Ontology:DOID:6432); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); acute myocardial infarction (Disease Ontology:DOID:9408); allergic asthma (Disease Ontology:DOID:9415)",
        "pathway": " (hsa:27121);  (R-HSA-201681);  (R-HSA-3772470);  (R-HSA-5339717)",
        "pathway_count": 4,
        "publication_count": 80,
        "publication_id_list": "10198061;10201374;10347172;10570958;11029007;11137016;11357136;11433302;11448771;11493532;11701963;11742004;12050670;12167704;12205098;12223464;12527209;12775774;12897152;14636582;14981260;15084453;15208637;15256437;15340161;15454084;15459103;15778503;15908424;16116452;16172602;16280981;16427602;16554443;16723543;16971168;17047023;17143291;17234765;17462603;17553464;18044981;18077588;18322270;18423204;18502762;18606139;19000841;19158955;19174556;19208630;19307728;19619488;19755491;20004982;20053636;20093360;21383061;21743455;21875946;21944579;21984209;22000855;22000856;22014570;22411803;22653731;22773843;22951645;22986341;23256519;23791946;29485866;29925589;31202458;32713860;35580925;9135132;9391096;9501980",
        "class_list": "",
        "function": "Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)., [UniProtKB]; Chromosome 8 mapping by FISH, [RefSeq, PubMed]; DKK4 may play a role in schizophrenia pathogenesis GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Dkk4 CRD2 mediates high-affinity binding to both the E1E2 region of low-density lipoprotein receptor-related protein 6 (LRP6 E1E2) and the Kremen1 (Krm1) extracellular domain., [RefSeq, PubMed]; Sensitization of hepatocellular carcinoma cells towards doxorubicin and sorafenib is facilitated by glucosedependent alterations in reactive oxygen species, P-glycoprotein and DKK4., [RefSeq, PubMed]; The data implied that DLX3 regulated Wnt/beta-catenin pathway through histone modification of DKK4 during the osteogenic differentiation of bone marrow mesenchymal stem cells., [RefSeq, PubMed]; This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 16,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3KNX0;Q9Y4C3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0048019 receptor antagonist activity;GO:0039706 co-receptor binding",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 8.3,
        "record_id": "Q9UBT3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UHI6-1",
        "uniprot_id": "DDX20_HUMAN",
        "mass": 92241.0,
        "length": 824,
        "protein_name": "Probable ATP-dependent RNA helicase DDX20",
        "gene_name": "DDX20",
        "organism": "Human",
        "refseq_name": "probable ATP-dependent RNA helicase DDX20",
        "refseq_ac": "NP_009135",
        "gene_names_uniprotkb": "DDX20; DP103; GEMIN3",
        "gene_names_refseq": "DDX20; DP103; GEMIN3",
        "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX20; 3.6.1.15; 3.6.4.13; Component of gems 3; DEAD box protein 20; DEAD box protein DP 103; Gemin-3",
        "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box protein 20; DEAD box protein DP 103; DEAD-box protein DP103; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; SMN-interacting protein; component of gems 3; gemin-3; probable ATP-dependent RNA helicase DDX20",
        "tax_id": 9606,
        "disease": "schizophrenia (Disease Ontology:DOID:5419); heroin dependence (Disease Ontology:DOID:9976)",
        "pathway": " (hsa:11218);  (R-HSA-191859);  (R-HSA-9754678)",
        "pathway_count": 3,
        "publication_count": 132,
        "publication_id_list": "10383418;10531003;10556282;10601333;10725331;10851237;11237011;11333016;11714716;11748230;12065586;12095920;12441251;12668731;12776181;15302935;16153597;16964243;17081983;17178713;17322306;18669648;18691976;18767875;18984161;19007248;19413330;19651622;19664994;19664995;19690332;19691289;19838190;20068231;20112406;20510246;20941364;21406692;21800163;23186163;23301498;24397554;24714562;24715725;25418920;25469497;25576301;25810538;25892735;26154972;26375851;26728094;26811146;26929215;26992070;27846572;27920218;28063628;28228285;28467828;28832583;28834231;28860189;28904123;29242379;29393594;29493099;29557506;29632046;29769354;29786170;30315122;30429286;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31998317;32157095;32265295;32357974;32387766;32488085;32502341;32680882;32908316;32938616;32983136;32995776;32995777;33080218;33141586;33188728;33268501;33298915;33392160;33479166;33592498;33633747;33691108;33717175;33912179;33963192;33968037;33981976;34087483;34171305;34211107;34315815;34357683;34373319;34509645;34561969;34624207;34932366;35051231;35561310;35580925;36010968;36011315;36241641;36246406;36581221;36610391;37938771;38665916;40914422;8196654;9845364",
        "class_list": "",
        "function": "A Macrophage Differentiation-Mediated Gene: DDX20 as a Molecular Biomarker Encompassing the Tumor Microenvironment, Disease Staging, and Prognoses in Hepatocellular Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]., [RefSeq]; Genetic Variation in DEAD-Box Helicase 20 as a Putative Marker of Recurrence in Propensity-Matched Colon Cancer Patients. Publication Status: Online-Only, [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 28,
        "reported_mutagensis": 0,
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        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DWV7;Q96F72;Q9NVM3;Q9UF59;Q9UIY0;Q9Y659",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;2.1.1.320;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;2.3.2.-;3.1.-.-;3.6.5.-;7.6.2.1;2.3.2.27;7.2.2.-;5.6.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;2.1.1.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;3.6.1.6;3.6.1.42;2.7.4.3",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006396 RNA processing;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0000244 spliceosomal tri-snRNP complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 13.5,
        "record_id": "Q9UHI6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y238-1",
        "uniprot_id": "DLEC1_HUMAN",
        "mass": 195684.0,
        "length": 1755,
        "protein_name": "Deleted in lung and esophageal cancer protein 1",
        "gene_name": "DLEC1",
        "organism": "Human",
        "refseq_name": "deleted in lung and esophageal cancer protein 1 isoform 3",
        "refseq_ac": "NP_001308082",
        "gene_names_uniprotkb": "DLEC1; DLC1",
        "gene_names_refseq": "CFAP81; DLC-1; DLC1; DLEC1; F56; FAP81",
        "protein_names_uniprotkb": "Deleted in lung and esophageal cancer protein 1; DLC-1; Deleted in lung cancer protein 1",
        "protein_names_refseq": "DLEC, cilia and flagella associated protein; cilia and flagella associated protein 81; deleted in lung and esophageal cancer 1; deleted in lung and esophageal cancer protein 1 isoform 3",
        "tax_id": 9606,
        "disease": "primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); stroke (Disease Ontology:DOID:0051061); allergic conjunctivitis (Disease Ontology:DOID:11204); esophagitis (Disease Ontology:DOID:11963); lung cancer (Disease Ontology:DOID:1324); pancreatic cancer (Disease Ontology:DOID:1793); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); interstitial lung disease (Disease Ontology:DOID:3082); atopic dermatitis (Disease Ontology:DOID:3310); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); cholangiocarcinoma (Disease Ontology:DOID:4947); esophageal cancer (Disease Ontology:DOID:5041); myocardial infarction (Disease Ontology:DOID:5844); acne (Disease Ontology:DOID:6543); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); renal tuberculosis (Disease Ontology:DOID:9733)",
        "pathway": " (hsa:9940)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "10213508;16756719;16959974;17081983;17099870;18191269;18594535;24222856;29557506;30610381;31176573;31844290;32144534;32161166;32350084;32938616;33144677;33153431;33592498;34087483;35051231;35251023;35580925;35661819;36010968;39894887",
        "class_list": "",
        "function": "Compared with negative methylation (Nm), DLEC1-positive methylation (Pm) was associated with increased GC risk in PS (OR 2.083, 95% CI 1.220-3.558, P = 0.007), but PBX3 Pm was not associated with GC risk., [RefSeq, PubMed]; DLEC1 is a candidate tumor suppressor gene that plays an important role in the development and progression of hepatocellular carcinoma., [RefSeq, PubMed]; DLEC1 methylation can be utilized to identify a subset with a better prognosis in intrahepatic cholangiocarcinomas of the small duct type., [RefSeq, PubMed]; DLEC1 methylation was an independent marker of poor survival in patients with non-small cell lung carcinoma., [RefSeq, PubMed]; DLEC1 suppresses the growth of ovarian cancer cells and its downregulation is closely associated with promoter hypermethylation and histone hypoacetylation, [RefSeq, PubMed]; Dlec1 is required for spermatogenesis and male fertility in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Essential for spermatogenesis and male fertility (By similarity). May play an important role in sperm head and tail formation (By similarity). May act as a tumor suppressor by inhibiting cell proliferation., [UniProtKB, PubMed, UniProtKB]; PM2.5 exposure and DLEC1 promoter methylation in Taiwan Biobank participants. Publication Status: Online-Only, [RefSeq, PubMed]; Silencing of DLEC1 expression by promoter hypermethylation and histone deacetylation may be important in nasopharyngeal carcinoma tumorigenesis., [RefSeq, PubMed]; That the KLF4 and DLEC1 genes can be considered potential methylation biomarkers for uterine leiomyomas, [RefSeq, PubMed]; The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
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        "reported_snv": 39,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 23,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NSW0;Q9NTG5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015631 tubulin binding;GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0002357 defense response to tumor cell",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q9Y238-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y2E4-1",
        "uniprot_id": "DIP2C_HUMAN",
        "mass": 170767.0,
        "length": 1556,
        "protein_name": "Disco-interacting protein 2 homolog C",
        "gene_name": "DIP2C",
        "organism": "Human",
        "refseq_name": "disco-interacting protein 2 homolog C",
        "refseq_ac": "NP_055789",
        "gene_names_uniprotkb": "DIP2C; KIAA0934",
        "gene_names_refseq": "DIP2C; KIAA0934",
        "protein_names_uniprotkb": "Disco-interacting protein 2 homolog C; DIP2 homolog C",
        "protein_names_refseq": "DIP2 disco-interacting protein 2 homolog C; DIP2 homolog C; disco interacting protein 2 homolog C; disco-interacting protein 2 homolog C; disconnected interacting protein 2 homolog C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22982)",
        "pathway_count": 1,
        "publication_count": 36,
        "publication_id_list": "11237011;12137943;16959974;19851296;19913121;20198315;24275569;25576301;25645385;26992070;27600516;28834231;28964575;29557506;29786170;30429286;30779550;31154438;31844290;31848261;32157095;32357974;32488085;32897882;32938616;33592498;33691108;33968037;33981976;34171305;35051231;35987071;36241641;37217939;38421105;41350704",
        "class_list": "",
        "function": "DIP2C polymorphisms are implicated in susceptibility and clinical phenotypes of autism spectrum disorder., [RefSeq, PubMed]; De novo variants predicting haploinsufficiency for DIP2C are associated with expressive speech delay., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed, PubMed]; The data revealed DIP2C expression level decreased in breast cancer, especially in basal-like and HER-2 subtypes, and could be a valuable target for diagnosis on specific subtype of breast cancer, [RefSeq, PubMed]; This gene encodes a member of the disco-interacting protein homolog 2 family. The protein shares strong similarity with a Drosophila protein which interacts with the transcription factor disco and is expressed in the nervous system. [provided by RefSeq, Oct 2008]., [RefSeq]; This publication discusses the expression pattern and potential function of similar genes in Drosophila and mouse., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
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        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DPI5;Q5SS78",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
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        "hit_score": 3.9,
        "record_id": "Q9Y2E4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43854-1",
        "uniprot_id": "EDIL3_HUMAN",
        "mass": 53765.0,
        "length": 480,
        "protein_name": "EGF-like repeat and discoidin I-like domain-containing protein 3",
        "gene_name": "EDIL3",
        "organism": "Human",
        "refseq_name": "EGF-like repeat and discoidin I-like domain-containing protein 3 isoform 2 precursor",
        "refseq_ac": "NP_001265571",
        "gene_names_uniprotkb": "EDIL3; DEL1",
        "gene_names_refseq": "DEL1; EDIL3",
        "protein_names_uniprotkb": "EGF-like repeat and discoidin I-like domain-containing protein 3; Developmentally-regulated endothelial cell locus 1 protein; Integrin-binding protein DEL1",
        "protein_names_refseq": "EGF like repeats and discoidin domains 3; EGF-like repeat and discoidin I-like domain-containing protein 3 isoform 2 precursor; EGF-like repeat and discoidin I-like domain-containing protein 3; EGF-like repeats and discoidin I-like domains 3; developmental endothelial locus-1; developmentally-regulated endothelial cell locus 1 protein; integrin-binding protein DEL1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10085);  (R-HSA-9926550)",
        "pathway_count": 2,
        "publication_count": 37,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;11518510;12074641;15001579;18090124;19292890;19578876;19590037;19940119;20418909;22601780;23584533;27862975;29557506;30716301;31831667;32157095;32543734;32897882;33592498;33968037;34217213;34725712;35508657;35561310;36010968;37986328;38279017;38396634;38456416;38665916;39089131;39358671;39990658;9168821;9420328",
        "class_list": "",
        "function": "Acts as an angiogenic factor in the context of solid tumor formation; the increase in vascularization accelerates tumor growth through decreased apoptosis, [RefSeq, PubMed]; Alpha v beta 5, alpha v beta 5 and their ligands Del-1 and L1 play an important role in the process of tumor cells moving from the original place., [RefSeq, PubMed]; Analysis of ANO6, HAPLN1, and EDIL3 Polymorphisms in Patients with Ankylosing Spondylitis in a Chinese Han Population: A Case-Control Study., [RefSeq, PubMed]; Del-1 Plays a Protective Role against COPD Development by Inhibiting Inflammation and Apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Downregulation of developmentally regulated endothelial cell locus-1 inhibits the growth of colon cancer., [RefSeq, PubMed]; Epidermal Growth Factor-Like Repeats and Discoidin I-Like Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination., [RefSeq, PubMed]; Exploration of MELK as a downstream of Del-1 and druggable targets in triple-negative breast cancer., [RefSeq, PubMed]; In silico analysis of DEL-1 and inflammation-related genes in lung squamous cell carcinoma., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development., [UniProtKB]; The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R763;O43855;Q5D094;Q8N610",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome;GO:1903561 extracellular vesicle",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0010811 positive regulation of cell-substrate adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "O43854-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60739-1",
        "uniprot_id": "EIF1B_HUMAN",
        "mass": 12824.0,
        "length": 113,
        "protein_name": "Eukaryotic translation initiation factor 1b",
        "gene_name": "EIF1B",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 1b",
        "refseq_ac": "NP_005866",
        "gene_names_uniprotkb": "EIF1B",
        "gene_names_refseq": "EIF1B; GC20",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 1b; Protein translation factor SUI1 homolog GC20; eIF1b",
        "protein_names_refseq": "eukaryotic translation initiation factor 1b; protein translation factor SUI1 homolog GC20; translation factor sui1 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10289)",
        "pathway_count": 1,
        "publication_count": 28,
        "publication_id_list": "10931946;21406692;23186163;23301498;23481700;24714562;26375851;26728094;27846572;28832583;29493099;29508533;29786170;31844290;32157095;32350084;32488085;32938616;32983136;33592498;33691108;33717175;33912179;33968037;34561969;35051231;35580925;37938771",
        "class_list": "",
        "function": "Probably involved in translation., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UQF8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0043024 ribosomal small subunit binding;GO:0003743 translation initiation factor activity",
        "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex",
        "go_biological_process": "GO:0006446 regulation of translational initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "O60739-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P00374-1",
        "uniprot_id": "DYR_HUMAN",
        "mass": 21453.0,
        "length": 187,
        "protein_name": "Dihydrofolate reductase",
        "gene_name": "DHFR",
        "organism": "Human",
        "refseq_name": "dihydrofolate reductase isoform 1",
        "refseq_ac": "NP_000782",
        "gene_names_uniprotkb": "DHFR",
        "gene_names_refseq": "DHFR1; DHFR; DYR",
        "protein_names_uniprotkb": "Dihydrofolate reductase; 1.5.1.3",
        "protein_names_refseq": "dihydrofolate reductase isoform 1",
        "tax_id": 9606,
        "disease": "diabetic encephalopathy (Disease Ontology:DOID:0050850); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); megaloblastic anemia (Disease Ontology:DOID:13382); cancer (Disease Ontology:DOID:162); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:1719);  (R-HSA-1474151);  (R-HSA-196757);  (R-HSA-69205)",
        "pathway_count": 4,
        "publication_count": 121,
        "publication_id_list": "10091649;10228158;10347183;10454584;10531334;10597240;10692433;10978331;11825621;11879202;11959842;11988738;12096917;12657784;12782299;12925791;12937168;14990995;15014447;15039552;15476407;15510213;15681865;16171773;16222560;16696853;16778797;17129779;17308042;1731871;17569517;17962486;18067453;18511317;1883349;19196009;19424049;19478082;19666465;19719239;19948730;20498374;21163947;21238436;21310276;21310277;21876184;21876188;22235121;2248959;23409799;23934049;24714562;24715725;24733394;25576301;25810538;2605182;26154972;26758079;26992070;27846572;29557506;3053686;31217245;31844290;31848261;32157095;32387766;32423175;32488085;32502341;32658475;33053560;33141586;33163492;33298915;33392160;3383852;33912179;33936100;33968037;34875176;34905670;35318648;3536512;35580925;37665322;37938771;3801490;3871768;4066659;6235374;6323448;6687716;7563095;7623816;7663943;7726158;7852378;7890613;7929342;8068008;8114698;8137809;8137944;8218174;8288595;8307017;8502995;8522195;8618861;8662720;8943353;9020173;9374868;9520412;9662327;9719595;9753690;9778043",
        "class_list": "",
        "function": "Catalyzes the reduction of 7,8-dihydrofolate (DHF) to 5,6,7,8-tetrahydrofolate in a NADPH-dependent manner (PubMed:12096917, PubMed:15039552, PubMed:17569517, PubMed:19196009, PubMed:19478082, PubMed:21876184, PubMed:9719595). Key enzyme in folate metabolism. Contributes to the nuclear and mitochondrial de novo thymidylate biosynthesis pathway (PubMed:21876188, PubMed:22235121). Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Dihydrofolate reductase activity controls neurogenic transitions in the developing neocortex., [RefSeq, PubMed]; Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]., [RefSeq]; Evolution of Optimized Hydride Transfer Reaction and Overall Enzyme Turnover in Human Dihydrofolate Reductase., [RefSeq, PubMed]; Evolutionary adaptation of DHFR via expression of enzyme isoforms with various binding properties and dynamics behavior: a bioinformatics and computational study. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DDD2;Q14130;Q6IRW8",
        "ec_number_list": "1.5.1.3",
        "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:1990825 sequence-specific mRNA binding;GO:0004146 dihydrofolate reductase activity;GO:0003729 mRNA binding;GO:0070402 NADPH binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005657 replication fork",
        "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0006260 DNA replication;GO:0017148 negative regulation of translation;GO:0006730 one-carbon metabolic process;GO:0046655 folic acid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "P00374-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P0CG22-1",
        "uniprot_id": "DR4L1_HUMAN",
        "mass": 30608.0,
        "length": 281,
        "protein_name": "Putative dehydrogenase/reductase SDR family member 4-like 1",
        "gene_name": "DHRS4L1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DHRS4L1; SDR25C4",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative dehydrogenase/reductase SDR family member 4-like 1; 1.1.-.-; Protein SDR25C4; Short chain dehydrogenase/reductase family 25C member 4",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 9,
        "publication_id_list": "19027726;27846572;28904123;29557506;30429286;31844290;32488085;33141586;35051231",
        "class_list": "",
        "function": "Putative oxidoreductase., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004090 carbonyl reductase (NADPH) activity",
        "go_cellular_component": "GO:0005777 peroxisome",
        "go_biological_process": "GO:0042574 retinal metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "P0CG22-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P19419-1",
        "uniprot_id": "ELK1_HUMAN",
        "mass": 44888.0,
        "length": 428,
        "protein_name": "ETS domain-containing protein Elk-1",
        "gene_name": "ELK1",
        "organism": "Human",
        "refseq_name": "ETS domain-containing protein Elk-1 isoform a",
        "refseq_ac": "NP_001107595",
        "gene_names_uniprotkb": "ELK1",
        "gene_names_refseq": "ELK1",
        "protein_names_uniprotkb": "ETS domain-containing protein Elk-1",
        "protein_names_refseq": "ELK1, ETS transcription factor; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1 isoform a; ETS domain-containing protein Elk-1; ETS-like gene 1; tyrosine kinase (ELK1) oncogene",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); Huntington's disease (Disease Ontology:DOID:12858); anxiety disorder (Disease Ontology:DOID:2030); transient cerebral ischemia (Disease Ontology:DOID:224); schizophrenia (Disease Ontology:DOID:5419)",
        "pathway": " (hsa:2002);  (R-HSA-198753);  (R-HSA-9031628);  (R-HSA-9609690);  (R-HSA-9634638)",
        "pathway_count": 5,
        "publication_count": 271,
        "publication_id_list": "10102273;10203854;10231026;10381005;10542244;10611221;10611312;10637505;10656257;10734128;10742173;10799319;10826704;10831586;10872467;10882540;10984481;11018254;11027551;11145955;11243864;11280768;11309409;11331872;11343657;11371562;11567222;11726503;11755530;11840323;11875118;11889117;11956230;11988758;12023815;12070310;12093740;12097262;12399542;12511643;12514134;12551909;12665513;12814430;12857923;12887893;12904306;12947314;1377233;14522948;14556286;14597720;14969744;14992729;15090535;15102911;15161978;15210726;15314172;15449318;15542842;15564374;15620361;1570299;15705661;15733869;15782123;15836632;15880109;15897899;15899879;15920481;15998468;16034366;16136673;16140760;16187211;16199154;16221685;16260776;16287845;1630903;16339507;16407550;16456541;16484497;16574654;16732277;16835357;17088210;17088211;17088212;17296730;17591614;17632064;17898216;18056528;18088355;18160048;18160653;18203656;1833716;18391968;18452278;18456662;18524893;18535146;1861162;18669648;18785877;19061646;19116276;19168130;19193899;19194657;19432968;19682613;19690332;19926875;20068231;20137095;2017159;2040600;20506119;2052361;20727996;2072895;21057636;2109185;21258408;21326363;21486943;21621608;21655091;21690215;22053691;22065583;22174689;22302795;22354998;2237820;22433566;23114923;23158473;23186163;23226423;23322625;23481700;23533340;23755307;24039841;24060757;24712764;24714562;25248477;2539641;25418920;25569790;25576301;25748042;26018600;26279144;26572645;26612202;2676516;26810856;27041596;27128622;27220739;27501258;27557932;27789988;27862975;28012964;28076410;28157711;28218747;28228285;28275114;28286024;28415052;28514659;28657654;28832583;28939839;29242379;29368606;29437277;29485866;29493099;29559111;29765550;30315122;30360396;30410026;30761409;30854565;3127059;31530632;31844290;31848261;32157095;32161166;32488085;32502341;32938616;32983136;33537174;33592498;33968037;34561969;35051231;36010968;36691407;3672127;37547727;39406892;40596516;7551568;7588619;7592934;7595538;7608156;7624335;7651411;7777577;7823924;7857651;7871435;7876254;7889942;7923378;8090221;8090222;8248782;8262053;8386592;8413279;8483478;8548291;8576248;8583621;8622654;8635462;8668170;8756618;8846788;8846918;8855261;8918830;9032251;9042862;9084409;9130707;9199319;9264403;9343422;9367995;9390517;9418898;9430721;9448290;9622090;9687510;9722618;9770464;9774344;9795224;9808461;9822744;9858769",
        "class_list": "",
        "function": "A-Kinase Anchor Protein 95 Is Involved in ERK1/2-Elk-1 Signal Transduction in Colon Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Complexities in Elk-1 transcription factor function and regulation, [RefSeq, PubMed]; Demonstrate that ELK-1 expression arises by a combination of leaky scanning and reinitiation, with the latter mediated by the small upstream ORF2 conserved in both spliced isoforms, [RefSeq, PubMed]; Role of ELK1 in regulating colorectal cancer progression: miR-31-5p/CDIP1 axis in CRC pathogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; The 5' UTR controls ribosomal access to the ELK-1 AUG initiation codon., [RefSeq, PubMed]; This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]., [RefSeq]; Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942)., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 28,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7H4;O75606;O95058;Q969X8;Q9UJM4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030425 dendrite;GO:0031966 mitochondrial membrane;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045471 response to ethanol;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 27.5,
        "record_id": "P19419-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P28324-1",
        "uniprot_id": "ELK4_HUMAN",
        "mass": 46900.0,
        "length": 431,
        "protein_name": "ETS domain-containing protein Elk-4",
        "gene_name": "ELK4",
        "organism": "Human",
        "refseq_name": "ETS domain-containing protein Elk-4 isoform a",
        "refseq_ac": "NP_001964",
        "gene_names_uniprotkb": "ELK4; SAP1",
        "gene_names_refseq": "ELK4; SAP1",
        "protein_names_uniprotkb": "ETS domain-containing protein Elk-4; SAP-1; SRF accessory protein 1; Serum response factor accessory protein 1",
        "protein_names_refseq": "ELK4, ETS transcription factor; ELK4, ETS-domain protein (SRF accessory protein 1); ETS domain-containing protein Elk-4 isoform a; ETS domain-containing protein Elk-4; SAP-1; serum response factor accessory protein 1",
        "tax_id": 9606,
        "disease": "chemical colitis (Disease Ontology:DOID:0060186); ileitis (Disease Ontology:DOID:0060189); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); liver disease (Disease Ontology:DOID:409); primary hyperaldosteronism (Disease Ontology:DOID:446); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); proteinuria (Disease Ontology:DOID:576); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256); pulmonary emphysema (Disease Ontology:DOID:9675)",
        "pathway": " (hsa:2005)",
        "pathway_count": 1,
        "publication_count": 54,
        "publication_id_list": "11237011;1339307;18452278;22722849;23186163;23481700;24366607;24715725;25418920;25576301;27846572;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29557506;29632711;29786170;30315122;30429286;30459171;31217245;31530632;31844290;31848261;32157095;32265295;32502341;32938616;32983136;33298915;33717175;33912179;34171305;34372882;34663788;35051231;36010968;36241641;36284347;37519006;37777542;38665916;39305302;8293474;9020136;9130707;9734357",
        "class_list": "",
        "function": "ELK4 Promotes Cell Cycle Progression and Stem Cell-like Characteristics in HPV-associated Cervical Cancer by Regulating the FBXO22/PTEN Axis., [RefSeq, PubMed]; ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis. Publication Status: Online-Only, [RefSeq, PubMed]; ELK4 targets CHMP6 to inhibit ferroptosis and enhance malignant properties of skin cutaneous melanoma cells. Publication Status: Online-Only, [RefSeq, PubMed]; ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis. Publication Status: Online-Only, [RefSeq, PubMed]; IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously., [UniProtKB, PubMed]; This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 22,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P28323;Q6GSJ2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "P28324-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P32926-1",
        "uniprot_id": "DSG3_HUMAN",
        "mass": 107533.0,
        "length": 999,
        "protein_name": "Desmoglein-3",
        "gene_name": "DSG3",
        "organism": "Human",
        "refseq_name": "desmoglein-3 preproprotein",
        "refseq_ac": "NP_001935",
        "gene_names_uniprotkb": "DSG3; CDHF6",
        "gene_names_refseq": "ABOLM; CDHF6; DSG3; PVA",
        "protein_names_uniprotkb": "Desmoglein-3; 130 kDa pemphigus vulgaris antigen; Cadherin family member 6; PVA",
        "protein_names_refseq": "130 kDa pemphigus vulgaris antigen; cadherin family member 6; desmoglein-3 preproprotein",
        "tax_id": 9606,
        "disease": "hypermethioninemia (Disease Ontology:DOID:0050544); pemphigus vulgaris (Disease Ontology:DOID:0060851); lipid metabolism disorder (Disease Ontology:DOID:3146); amino acid metabolic disorder (Disease Ontology:DOID:9252); blistering, acantholytic, of oral and laryngeal mucosa (MONDO:MONDO:0030986)",
        "pathway": " (hsa:1830);  (R-HSA-351906);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 4,
        "publication_count": 85,
        "publication_id_list": "37268159;10.1038/emboj.2013.79;10066784;10196183;10231017;10411887;10588656;10748026;10771479;11076937;11350120;11380615;11500511;11590230;11790773;12902340;15033990;15054114;15337775;15373777;15797384;15803139;16061697;16286477;16382671;16639001;16740002;1691188;1694855;1714783;1720352;17515931;17521629;17559062;17562024;17596512;18343367;18843291;19190773;19194479;19717567;20058876;20179351;20657595;20667819;20940292;21439340;21654840;21997417;22294297;22796473;23090970;23481192;23481700;23584533;23629652;2414304;24190977;24220297;25208914;25576301;25926655;26375851;26390218;26763450;30528827;30949721;31835537;32162841;32938616;33766510;35051231;37217939;37262304;37717934;37850634;38253038;38900156;7543090;8824274;8999895;9395522;9468612;9565599;9701552",
        "class_list": "",
        "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:31835537). Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes (PubMed:31835537). Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle (PubMed:9701552). Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells (By similarity). May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 (PubMed:22294297). Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG (PubMed:31835537). May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation (PubMed:31835537). Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 (PubMed:22796473). The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity (PubMed:22294297). Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing (PubMed:26763450)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Homozygous deletion of the DSG3 terminal exon associated with acantholytic blistering of the oral and laryngeal mucosa., [RefSeq, PubMed]; Interleukin-37 inhibits desmoglein-3 endocytosis and keratinocyte dissociation via upregulation of Caveolin-1 and inhibition of the STAT3 pathway., [RefSeq, PubMed]; Mutant TP53 promotes invasion of lung cancer cells by regulating desmoglein 3. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016]., [RefSeq]; Type 2 T-Cell Responses against Distinct Epitopes of the Desmoglein 3 Ectodomain in Pemphigus Vulgaris., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 3,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 10,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 10,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 56,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 5,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2V2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction",
        "go_biological_process": "GO:0120192 tight junction assembly;GO:0007015 actin filament organization;GO:0030336 negative regulation of cell migration;GO:0098609 cell-cell adhesion;GO:0031647 regulation of protein stability",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "P32926-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P40939-1",
        "uniprot_id": "ECHA_HUMAN",
        "mass": 83000.0,
        "length": 763,
        "protein_name": "Trifunctional enzyme subunit alpha, mitochondrial",
        "gene_name": "HADHA",
        "organism": "Human",
        "refseq_name": "trifunctional enzyme subunit alpha, mitochondrial precursor",
        "refseq_ac": "NP_000173",
        "gene_names_uniprotkb": "HADHA; HADH",
        "gene_names_refseq": "ECHA; GBP; HADHA; LCEH; LCHAD; MLCL AT; MTPA; TP-ALPHA",
        "protein_names_uniprotkb": "Trifunctional enzyme subunit alpha, mitochondrial; 2.3.1.-; 78 kDa gastrin-binding protein; MLCL AT; Monolysocardiolipin acyltransferase; TP-alpha",
        "protein_names_refseq": "3-ketoacyl-Coenzyme A (CoA) thiolase, alpha subunit; 3-oxoacyl-CoA thiolase; 78 kDa gastrin-binding protein; gastrin-binding protein; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit; long-chain 2-enoyl-CoA hydratase; long-chain-3-hydroxyacyl-CoA dehydrogenase; mitochondrial long-chain 2-enoyl-Coenzyme A (CoA) hydratase, alpha subunit; mitochondrial long-chain L-3-hydroxyacyl-Coenzyme A (CoA) dehydrogenase, alpha subunit; mitochondrial trifunctional enzyme, alpha subunit; mitochondrial trifunctional protein, alpha subunit; monolysocardiolipin acyltransferase; trifunctional enzyme subunit alpha, mitochondrial precursor",
        "tax_id": 9606,
        "disease": "long chain 3-hydroxyacyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0061186); mitochondrial trifunctional protein deficiency 1 (Disease Ontology:DOID:0070619); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); mitochondrial trifunctional protein deficiency (Disease Ontology:DOID:0111277); Alzheimer's disease (Disease Ontology:DOID:10652); lipid metabolism disorder (Disease Ontology:DOID:3146); steatotic liver disease (Disease Ontology:DOID:9452)",
        "pathway": " (hsa:3030);  (R-HSA-1482798);  (R-HSA-77285);  (R-HSA-77288);  (R-HSA-77305);  (R-HSA-77310);  (R-HSA-77346);  (R-HSA-77348);  (R-HSA-77350)",
        "pathway_count": 9,
        "publication_count": 140,
        "publication_id_list": "10.1101/2023.09.13.557529;10075708;10092647;10336645;11237011;12654921;13295225;13295248;14551214;15152008;1540149;1550553;17081983;17082194;18479707;19075029;19416660;19608861;19737925;20068231;22424782;23152787;23186163;23271734;23481700;24275569;24715725;25418920;25576301;25645385;25810538;26154972;26375851;26474213;26768311;26811146;26992070;27090790;27452731;27600516;27846572;27862975;27920218;28218747;28228285;28649982;28832583;28904123;29242379;29351928;29393594;29437277;29508533;29557506;29632711;29774024;29786170;29915090;30315122;30379171;30397120;30410026;30429286;30779550;30850536;31020640;31154438;31217245;31530632;31604922;31611695;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32265295;32350084;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33123756;33141586;33298915;33392160;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34405274;34433824;34509645;34725712;34932366;35051231;35083852;35132862;35154160;35318648;3597357;36010968;36215666;36224682;36241641;36284347;37074911;37217939;37549033;37843279;37938771;38372965;38501492;38665916;39302247;40596516;7811722;7846063;7918661;8083230;8135828;8163672;8651282;8687463;8770876;9266371;9417066;9487141;9739053",
        "class_list": "",
        "function": "An Autopsy Analysis of a Patient With Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Caused by Compound Heterozygous HADHA Gene Mutations., [RefSeq, PubMed]; Cardiac phenotype in adolescents and young adults with long-chain 3-hydroxyacyl CoA dehydrogenase (LCHAD) deficiency., [RefSeq, PubMed]; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:1550553, PubMed:29915090, PubMed:30850536, PubMed:8135828, PubMed:31604922). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through cycles of four consecutive reactions (PubMed:29915090). Each beta-oxidation cycle shortens the fatty acyl-CoA by two carbons, yielding one acetyl-CoA (for the citric acid cycle), one FADH(2), and one NADH (which donate electrons to the respiratory chain for ATP production) (PubMed:29915090). These cycles repeat until the chain is fully degraded to acetyl-CoA units (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional protein--responsible for the hydration, dehydrogenation, and thiolysis steps, shows specificity for long-chain fatty acids, such as those from dietary and stored fats (PubMed:30850536, PubMed:31604922). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity (Probable) (PubMed:29915090, PubMed:30850536, PubMed:8135828). These activities have been experimentally confirmed on a few substrates derived from beta-oxidation of long-chain saturated fatty acids such as palmitate (hexadecanoate) and laurate (dodecanoate) (PubMed:1550553, PubMed:8135828, PubMed:8163672, PubMed:8651282). In addition, based on its established catalytic mechanism, and combined genetic interaction or mutant phenotype evidence, it is predicted to act also on other substrates, including long-chain unsaturated fatty acids such as oleate (9Z-octadecenoate), linoleate (9Z,12Z-octadecadienoate), linolenate (9Z,12Z,15Z-octadecatrienoate), and others (Probable) (PubMed:26474213). Independently of subunit beta, HADHA also exhibits a cardiolipin acyltransferase activity that participates in cardiolipin remodeling; cardiolipin is a major mitochondrial membrane phospholipid (PubMed:23152787, PubMed:31604922). HADHA may act downstream of Tafazzin/TAZ, that remodels monolysocardiolipin (MLCL) to a cardiolipin intermediate, and then HADHA may continue to remodel this species into mature tetralinoleoyl-cardiolipin (PubMed:31604922). Has also been proposed to act directly on MLCL; capable of acylating MLCL using different acyl-CoA substrates, with highest activity for oleoyl-CoA (PubMed:23152787)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008]., [RefSeq]; Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation. Publication Status: Online-Only, [RefSeq, PubMed]; [HADHA Inhibits the Migration and Invasion of HTR-8/SVneo Cells by Regulating PI3K/AKT Signaling Pathway]., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 7,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7L4;B4DYP2;Q16679;Q53T69;Q53TA2;Q96GT7;Q9UQC5",
        "ec_number_list": "1.3.8.7;1.3.8.8;4.2.1.17;5.3.3.8;1.1.1.211;2.3.1.-;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159",
        "go_molecular_function": "GO:0016509 long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity;GO:0070403 NAD+ binding;GO:0004300 enoyl-CoA hydratase activity;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0003985 acetyl-CoA C-acetyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid;GO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex",
        "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0035965 cardiolipin acyl-chain remodeling;GO:0006631 fatty acid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 14.9,
        "record_id": "P40939-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P52797-1",
        "uniprot_id": "EFNA3_HUMAN",
        "mass": 26350.0,
        "length": 238,
        "protein_name": "Ephrin-A3",
        "gene_name": "EFNA3",
        "organism": "Human",
        "refseq_name": "ephrin-A3 precursor",
        "refseq_ac": "NP_004943",
        "gene_names_uniprotkb": "EFNA3; EFL2; EPLG3; LERK3",
        "gene_names_refseq": "EFL2; EFNA3; EPLG3; Ehk1-L; LERK3",
        "protein_names_uniprotkb": "Ephrin-A3; EFL-2; EHK1 ligand; EHK1-L; EPH-related receptor tyrosine kinase ligand 3; LERK-3",
        "protein_names_refseq": "EFL-2; EHK1 ligand; LERK-3; eph-related receptor tyrosine kinase ligand 3; ephrin-A3 precursor; ligand of eph-related kinase 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1944);  (R-HSA-2682334);  (R-HSA-3928663);  (R-HSA-3928665)",
        "pathway_count": 4,
        "publication_count": 46,
        "publication_id_list": "10.1101/2023.09.13.557529;10769020;10848605;11179879;11448999;11780069;12084815;12495863;12973357;15351694;15848799;15848800;16511561;17322526;17428795;17928214;18713744;19525919;20496116;23090970;24190977;24714562;24715725;25576301;29242379;29741879;31530632;31844290;31998317;32157095;32350084;32387766;33298915;33912179;33968037;34357683;35227773;35251023;35345980;35580925;35770949;35850484;36191606;7838529;7973638;9499402",
        "class_list": "",
        "function": "Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity)., [UniProtKB]; Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma., [RefSeq, PubMed]; EphrinA3 is a key regulator of malignant behaviors and a potential prognostic factor in lung adenocarcinoma., [RefSeq, PubMed]; Hsa_circ_0007478 aggravates NLRP3 inflammasome activation and lipid metabolism imbalance in ox-LDL-stimulated macrophage via miR-765/EFNA3 axis., [RefSeq, PubMed]; LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis., [RefSeq, PubMed]; Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway., [RefSeq, PubMed]; This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 8836,
        "biomarker_type": "",
        "glycan_count": 15,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZAD3;D3DV85;Q0VGC9;Q5SR70",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046875 ephrin receptor binding;GO:0005005 transmembrane-ephrin receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane",
        "go_biological_process": "GO:0007267 cell-cell signaling;GO:0048013 ephrin receptor signaling pathway;GO:0016525 negative regulation of angiogenesis;GO:0007411 axon guidance;GO:1902993 positive regulation of amyloid precursor protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.4,
        "record_id": "P52797-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P57055-1",
        "uniprot_id": "DSCR6_HUMAN",
        "mass": 20368.0,
        "length": 190,
        "protein_name": "Protein ripply3",
        "gene_name": "RIPPLY3",
        "organism": "Human",
        "refseq_name": "protein ripply3 isoform 2",
        "refseq_ac": "NP_001304697",
        "gene_names_uniprotkb": "RIPPLY3; DSCR6",
        "gene_names_refseq": "DSCR6; RIPPLY3",
        "protein_names_uniprotkb": "Protein ripply3; Down syndrome critical region protein 6",
        "protein_names_refseq": "Down syndrome critical region gene 6; down syndrome critical region protein 6; protein ripply3 isoform 2; protein ripply3; ripply3 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:53820)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "10814524;16326386;30241482;31844290",
        "class_list": "",
        "function": "Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity)., [UniProtKB]; Deleterious variants in RIPPLY3 are potential molecular mechanisms involved in the pathogenesis of human Conotruncal heart defect. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0060037 pharyngeal system development;GO:0009880 embryonic pattern specification",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "P57055-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P59020-1",
        "uniprot_id": "DSCR9_HUMAN",
        "mass": 16743.0,
        "length": 149,
        "protein_name": "Down syndrome critical region protein 9",
        "gene_name": "DSCR9",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DSCR9",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Down syndrome critical region protein 9",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "12168953",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8P8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "P59020-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P60608-1",
        "uniprot_id": "EFC2_HUMAN",
        "mass": 58319.0,
        "length": 527,
        "protein_name": "Endogenous retrovirus group FC1 member 1 Env polyprotein",
        "gene_name": "ERVFC1-1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "ERVFC1-1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Endogenous retrovirus group FC1 member 1 Env polyprotein; Envelope polyprotein; Fc2deltaenv; HERV-F(c)2_7q36.2 provirus ancestral Env polyprotein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 7,
        "publication_id_list": "11689652;12890629;12970426;14557543;30524438;32265295;35051231",
        "class_list": "",
        "function": "Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "total_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0075523 viral translational frameshifting",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "P60608-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16610-1",
        "uniprot_id": "ECM1_HUMAN",
        "mass": 60674.0,
        "length": 540,
        "protein_name": "Extracellular matrix protein 1",
        "gene_name": "ECM1",
        "organism": "Human",
        "refseq_name": "extracellular matrix protein 1 isoform 3 precursor",
        "refseq_ac": "NP_001189787",
        "gene_names_uniprotkb": "ECM1",
        "gene_names_refseq": "ECM1; URBWD",
        "protein_names_uniprotkb": "Extracellular matrix protein 1; Secretory component p85",
        "protein_names_refseq": "extracellular matrix protein 1 isoform 3 precursor; secretory component p85; testicular tissue protein Li 61",
        "tax_id": 9606,
        "disease": "lipoid proteinosis (Disease Ontology:DOID:14498)",
        "pathway": " (hsa:1893);  (R-HSA-114608)",
        "pathway_count": 2,
        "publication_count": 54,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;11165938;11292659;11929856;12603844;12604605;1435334;14630798;15297306;16335952;16512877;19139490;19275936;23399548;23584533;23640497;24190977;25813380;26375851;26791533;27600516;29391424;29557506;29741879;30237853;30315122;30459171;30484775;31154438;31844290;32157095;32350084;32373127;32387766;32938616;34509645;35051231;35251023;35580925;36241641;36284347;37074911;37938771;38613239;38665916;38842389;38849014;39470347;6457647;8467233;9367673;9501329",
        "class_list": "",
        "function": "A founder deletion in ECM1 of 1163 bp causes lipoid proteinosis in the southeast region of Turkiye., [RefSeq, PubMed]; ECM1 and KRT6A are involved in tumor progression and chemoresistance in the effect of dexamethasone on pancreatic cancer., [RefSeq, PubMed]; Extracellular matrix protein 1 binds to connective tissue growth factor against liver fibrosis and ductular reaction. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity., [UniProtKB, PubMed, PubMed, PubMed]; Remodeling of tumor microenvironment by extracellular matrix protein 1a differentially regulates ovarian cancer metastasis., [RefSeq, PubMed]; This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 18,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 19,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 19,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 48,
        "disease_count": 1,
        "glyco_site_count": 23,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8S0;B4DW49;B4DY60;O43266;Q5T5G4;Q5T5G5;Q5T5G6;Q8IZ60",
        "ec_number_list": "",
        "go_molecular_function": "GO:0002020 protease binding;GO:0005134 interleukin-2 receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome;GO:0031089 platelet dense granule lumen",
        "go_biological_process": "GO:0010466 negative regulation of peptidase activity;GO:0001525 angiogenesis;GO:0007165 signal transduction;GO:0045766 positive regulation of angiogenesis;GO:0043123 positive regulation of canonical NF-kappaB signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 12.7,
        "record_id": "Q16610-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZTU2-1",
        "uniprot_id": "E400N_HUMAN",
        "mass": 51753.0,
        "length": 488,
        "protein_name": "Putative chromatin regulator EP400P1",
        "gene_name": "EP400P1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "EP400P1; EP400NL",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative chromatin regulator EP400P1; EP400 N-terminal-like; EP400 pseudogene 1; Putative EP400-like protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "26154972;26992070;29485866;31844290;35051231;36328277",
        "class_list": "",
        "function": "May be a component of a SWR1-like complex that displays H2A.Z deposition activity and is involved in transcription initiation-coupled chromatin remodeling (PubMed:36328277). The SWR1-like complex lacks histone acetyltransferase activity (PubMed:36328277)., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NLB7;A8K0Z5;B3KQY2;Q6NXP1;Q8N253;Q8N7S7;Q9UFJ3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000812 Swr1 complex",
        "go_biological_process": "GO:0045815 transcription initiation-coupled chromatin remodeling",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q6ZTU2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N6I1-1",
        "uniprot_id": "EID2_HUMAN",
        "mass": 25190.0,
        "length": 236,
        "protein_name": "EP300-interacting inhibitor of differentiation 2",
        "gene_name": "EID2",
        "organism": "Human",
        "refseq_name": "EP300-interacting inhibitor of differentiation 2",
        "refseq_ac": "NP_694964",
        "gene_names_uniprotkb": "EID2; CRI2",
        "gene_names_refseq": "CRI2; EID-2; EID2",
        "protein_names_uniprotkb": "EP300-interacting inhibitor of differentiation 2; CREBBP/EP300 inhibitor 2; EID-1-like inhibitor of differentiation 2; EID-2",
        "protein_names_refseq": "CREBBP/EP300 inhibitor 2; CREBBP/EP300 inhibitory protein 2; E1A like inhibitor of differentiation 2; EID-1-like inhibitor of differentiation 2; EP300-interacting inhibitor of differentiation 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:163126)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "12586827;14585496;14612439;15970276;23481700;24129315;24714562;25418920;25576301;26811146;26929215;28228285;28832583;29242379;29331515;29393594;29632046;30429286;31154438;31530632;31844290;31848261;32161166;32265295;32387766;33592498;33968037",
        "class_list": "",
        "function": "EID-2 may function as an endogenous suppressor of TGF-beta signaling, [RefSeq, PubMed]; Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7YQ71;Q6X7T0;Q6ZR61",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0046332 SMAD binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0042127 regulation of cell population proliferation;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q8N6I1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NBI3-1",
        "uniprot_id": "DRAXI_HUMAN",
        "mass": 38650.0,
        "length": 349,
        "protein_name": "Draxin",
        "gene_name": "DRAXIN",
        "organism": "Human",
        "refseq_name": "draxin precursor",
        "refseq_ac": "NP_940947",
        "gene_names_uniprotkb": "DRAXIN; C1orf187; PRO10268; PSEC0258",
        "gene_names_refseq": "AGPA3119; C1orf187; DRAXIN; UNQ3119; neucrin",
        "protein_names_uniprotkb": "Draxin; Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; Neucrin",
        "protein_names_refseq": "dorsal repulsive axon guidance protein; draxin precursor; neural tissue-specific cysteine-rich protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:374946)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "10.1038/emboj.2013.79;12975309;15340161;16303743;19857465;23584533;24832731;29557506;31844290;33945466;36040678;36241641;38253038",
        "class_list": "",
        "function": "Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway., [UniProtKB, HAMAP]; DRAXIN as a Novel Diagnostic Marker to Predict the Poor Prognosis of Glioma Patients., [RefSeq, PubMed]; DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation. Publication Status: Online-Only, [RefSeq, PubMed]; Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues., [RefSeq, PubMed]; Results suggest that draxin functions as a repulsive guidance cue for PCN migration. However, we observed no significant differences in PCN distribution between draxin(-/-) and wild type embryos., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B6EV15;Q5SNX0;Q6UWK8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0060090 molecular adaptor activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0021516 dorsal spinal cord development;GO:0030900 forebrain development;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0010977 negative regulation of neuron projection development;GO:0016055 Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q8NBI3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NEX9-1",
        "uniprot_id": "DR9C7_HUMAN",
        "mass": 35263.0,
        "length": 313,
        "protein_name": "Short-chain dehydrogenase/reductase family 9C member 7",
        "gene_name": "SDR9C7",
        "organism": "Human",
        "refseq_name": "short-chain dehydrogenase/reductase family 9C member 7",
        "refseq_ac": "NP_683695",
        "gene_names_uniprotkb": "SDR9C7; RDHS; SDRO",
        "gene_names_refseq": "ARCI13; RDHS; SDR-O; SDR9C7; SDRO",
        "protein_names_uniprotkb": "Short-chain dehydrogenase/reductase family 9C member 7; 1.1.1.-; O-acylceramide dehydrogenase; Orphan short-chain dehydrogenase/reductase; RDH-S; SDR-O; SDR9C7",
        "protein_names_refseq": "O-acylceramide dehydrogenase; RDH-S; orphan short-chain dehydrogenase / reductase; orphan short-chain dehydrogenase/reductase; retinol dehydrogenase similar protein; short-chain dehydrogenase/reductase family 9C member 7",
        "tax_id": 9606,
        "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); autosomal recessive congenital ichthyosis 13 (Disease Ontology:DOID:0080257)",
        "pathway": " (hsa:121214);  (R-HSA-2453902)",
        "pathway_count": 2,
        "publication_count": 48,
        "publication_id_list": "10075733;10617778;10753906;11123914;11274389;12036956;12177057;12234675;12407145;15314061;15471866;15865448;17255476;19027726;19049981;1925597;19309693;19703561;20112406;20192770;21493626;21774515;22665496;2303470;23481700;24275569;2542268;28173123;28369735;28906551;31671075;3170584;31953843;33422619;37074911;5315589;6288450;6342691;6512705;6589631;6679757;7929238;8105993;8884265;9490294;9541407;9703434;9920938",
        "class_list": "",
        "function": "Knockdown of SDR9C7 Impairs Epidermal Barrier Function., [RefSeq, PubMed]; Missense mutations in SDR9C7 gene were identified in families with autosomal recessive congenital ichthyosis: two families shared an identical homozygous mutation c.599T > C (p.Ile200Thr) and one family had another homozygous mutation c.214C > T (p.Arg72Trp). The mutations severely affected a stability of the protein. In a patient's skin, SDR9C7 gene expression in the cornified layer was decreased., [RefSeq, PubMed]; Next-generation sequencing through multi-gene panel testing for diagnosis of hereditary ichthyosis in Chinese., [RefSeq, PubMed]; Plays a crucial role in the formation of the epidermal permeability barrier (PubMed:31671075). Catalyzes the NAD+-dependent dehydrogenation of the linoleate 9,10-trans-epoxy-11E-13-alcohol esterified in omega-O-acylceramides (such as in N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoyloxy]-acylsphing-4E-enine) to the corresponding 13-ketone, the reactive moiety required for binding of epidermal ceramides to proteins (PubMed:31671075). Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity (PubMed:19703561)., [UniProtKB, PubMed, PubMed]; The authors report a novel mutation in SDR9C7 responsible for ARCI in a Pakistani family., [RefSeq, PubMed]; The results strongly support the findings of previous studies,2-5 and thus provide further evidence that SDR9C7 is a novel causative gene for ARCI., [RefSeq, PubMed]; This gene encodes a protein with similarity to the short-chain dehydrogenase/reductase (SDR) family but has not been shown to have retinoid or dehydrogenase activities. [provided by RefSeq, Apr 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 9474,
        "biomarker_type": "",
        "glycan_count": 16,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVB4",
        "ec_number_list": "1.1.1.62;1.1.1.239;1.1.1.105;1.1.1.209;1.1.1.53;1.1.1.315;1.1.1.-",
        "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0042572 retinol metabolic process;GO:0008202 steroid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q8NEX9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TD84-1",
        "uniprot_id": "DSCL1_HUMAN",
        "mass": 224463.0,
        "length": 2053,
        "protein_name": "Cell adhesion molecule DSCAML1",
        "gene_name": "DSCAML1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "DSCAML1; DSCAM2; KIAA1132",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Cell adhesion molecule DSCAML1; Down syndrome cell adhesion molecule 2; Down syndrome cell adhesion molecule-like protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); ocular motor apraxia, Cogan type (Disease Ontology:DOID:0080849); ocular motility disease (Disease Ontology:DOID:1279); Down syndrome (Disease Ontology:DOID:14250)",
        "pathway": " (hsa:57453);  (R-HSA-376172)",
        "pathway_count": 2,
        "publication_count": 18,
        "publication_id_list": "10925149;11237011;11453658;12051741;16959974;18216854;18216855;23481700;28228285;29351928;29393594;29557506;30192525;31844290;33592498;34171305;35051231;38253038",
        "class_list": "",
        "function": "Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells. Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 23,
        "predicted_n_glycosites": 20,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 73,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 25,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G3V1B5;Q76MU9;Q8IZY3;Q8IZY4;Q8WXU7;Q9ULT7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0098632 cell-cell adhesion mediator activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0045202 synapse",
        "go_biological_process": "GO:0007409 axonogenesis;GO:0007417 central nervous system development;GO:0007420 brain development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009953 dorsal/ventral pattern formation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q8TD84-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TE73-1",
        "uniprot_id": "DYH5_HUMAN",
        "mass": 529021.0,
        "length": 4624,
        "protein_name": "Dynein axonemal heavy chain 5",
        "gene_name": "DNAH5",
        "organism": "Human",
        "refseq_name": "dynein axonemal heavy chain 5",
        "refseq_ac": "NP_001360",
        "gene_names_uniprotkb": "DNAH5; DNAHC5; HL1; KIAA1603",
        "gene_names_refseq": "CILD3; DNAH5; DNAHC5; HL1; KTGNR; PCD",
        "protein_names_uniprotkb": "Dynein axonemal heavy chain 5; Axonemal beta dynein heavy chain 5; Ciliary dynein heavy chain 5",
        "protein_names_refseq": "axonemal beta dynein heavy chain 5; ciliary dynein heavy chain 5; dynein axonemal heavy chain 5; dynein heavy chain 5, axonemal; dynein, axonemal, heavy polypeptide 5",
        "tax_id": 9606,
        "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); episodic ataxia type 1 (Disease Ontology:DOID:0050989); developmental and epileptic encephalopathy 32 (Disease Ontology:DOID:0080416); primary ciliary dyskinesia 3 (Disease Ontology:DOID:0110599); sensorineural hearing loss (Disease Ontology:DOID:10003); otitis media (Disease Ontology:DOID:10754); epilepsy (Disease Ontology:DOID:1826); tetralogy of Fallot (Disease Ontology:DOID:6419); primary ciliary dyskinesia (Disease Ontology:DOID:9562)",
        "pathway": " (hsa:1767)",
        "pathway_count": 1,
        "publication_count": 45,
        "publication_id_list": "11062149;11237011;11788826;16627867;17924679;19664994;21496787;23481700;25186273;27600516;27893789;28228285;28832583;28904123;29393594;29557506;29632711;29769354;29789417;30192525;31178125;31844290;32157095;32488085;32502341;32938616;33141586;33968037;33981976;34087483;34171305;34962988;35051231;35251023;35494241;35869121;35960414;36010968;36215666;36241641;36864285;37217939;37340703;38022557;8812413",
        "class_list": "",
        "function": "Characteristic genetic spectrum of primary ciliary dyskinesia in Japanese patients and global ethnic heterogeneity: population-based genomic variation database analysis., [RefSeq, PubMed]; DNAH5 gene and its correlation with linc02220 expression and sperm characteristics., [RefSeq, PubMed]; Force generating protein of respiratory cilia (By similarity). Produces force towards the minus ends of microtubules (By similarity). Key component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness. Publication Status: Online-Only, [RefSeq, PubMed]; Identification and validation of a prognostic-related mutant gene DNAH5 for hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Novel homozygous mutations of DNAH5 in Kartagener syndrome., [RefSeq, PubMed]; This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 248,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 10,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q92860;Q96L74;Q9H5S7;Q9HCG9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0036157 outer dynein arm",
        "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0003341 cilium movement",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q8TE73-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q92611-1",
        "uniprot_id": "EDEM1_HUMAN",
        "mass": 73768.0,
        "length": 657,
        "protein_name": "ER degradation-enhancing alpha-mannosidase-like protein 1",
        "gene_name": "EDEM1",
        "organism": "Human",
        "refseq_name": "ER degradation-enhancing alpha-mannosidase-like protein 1",
        "refseq_ac": "NP_055489",
        "gene_names_uniprotkb": "EDEM1; EDEM; KIAA0212",
        "gene_names_refseq": "EDEM1; EDEM",
        "protein_names_uniprotkb": "ER degradation-enhancing alpha-mannosidase-like protein 1",
        "protein_names_refseq": "ER degradation enhancer, mannosidase alpha-like 1; ER degradation-enhancing alpha-mannosidase-like 1; ER degradation-enhancing alpha-mannosidase-like protein 1",
        "tax_id": 9606,
        "disease": "cystic fibrosis (Disease Ontology:DOID:1485)",
        "pathway": " (hsa:9695);  (R-HSA-381038);  (R-HSA-901032)",
        "pathway_count": 3,
        "publication_count": 112,
        "publication_id_list": "10.1101/2023.09.13.557529;10409699;10601334;10694380;10827079;11237011;12204115;12610306;12913004;15466936;15579471;15713668;16431915;16449189;16461360;16539657;18003979;18264092;18417469;18426978;18664523;19084021;19524542;19934218;20112406;21282569;22424782;23232094;23481700;24190977;24714562;24715725;25092655;25418920;25469497;25505266;25576301;25645385;25892735;26154972;26375851;26728094;26811146;26929215;26992070;27846572;27920218;28063628;28218747;28228285;28514659;28649982;28832583;28834231;28860189;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30281916;30315122;30524438;30779550;31154438;31611695;31844290;31998317;32083795;32157095;32265295;32357974;32387766;32423001;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33691108;33717175;33912179;33968037;34087483;34185709;34509645;34698634;34932366;35008544;35051231;35318648;35580925;36010968;36284347;36581221;37074911;37938771;7590364;8666242;9037597;9450183;9473480",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "A somatic variant of EDEM1 (N198I) alters ATF6 signaling and provides a selective advantage to the transforming cells and results in hepatocellular carcinoma., [RefSeq, PubMed]; Cleavage and degradation of EDEM1 promotes coxsackievirus B3 replication via ATF6a-mediated unfolded protein response signalling., [RefSeq, PubMed]; EDEM was shown to extract misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle [EDEM], [RefSeq, PubMed]; EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired. Publication Status: Online-Only, [RefSeq, PubMed]; EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-beta Production. Publication Status: Online-Only, [RefSeq, PubMed]; EDEM1 is a soluble protein of the ER lumen in HEK293 cells, [RefSeq, PubMed]; Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 908,
        "reported_interactions": 0,
        "missing_score": 9507,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 1,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9C8;B4DXP3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0051787 misfolded protein binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0044322 endoplasmic reticulum quality control compartment;GO:0016020 membrane",
        "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:1904380 endoplasmic reticulum mannose trimming;GO:1904154 positive regulation of retrograde protein transport, ER to cytosol",
        "synthesized_glycan_count": 0,
        "hit_score": 12.4,
        "record_id": "Q92611-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96D98-1",
        "uniprot_id": "EID2B_HUMAN",
        "mass": 16985.0,
        "length": 161,
        "protein_name": "EP300-interacting inhibitor of differentiation 2B",
        "gene_name": "EID2B",
        "organism": "Human",
        "refseq_name": "EP300-interacting inhibitor of differentiation 2B",
        "refseq_ac": "NP_689574",
        "gene_names_uniprotkb": "EID2B; EID3",
        "gene_names_refseq": "EID-2B; EID-3; EID2B",
        "protein_names_uniprotkb": "EP300-interacting inhibitor of differentiation 2B; EID-2-like inhibitor of differentiation 3; EID-2B; EID-3",
        "protein_names_refseq": "EID-2-like inhibitor of differentiation-3; EP300-interacting inhibitor of differentiation 2B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:126272)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "15970276;23481700;28228285;29242379;29393594;30315122;31154438;31530632;31844290;32157095;32357974;33592498;33968037;36010968",
        "class_list": "",
        "function": "Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation., [UniProtKB, PubMed]; EID-3 inhibits MyoD- and GRalpha-dependent transcription and blocked muscle differentiation in cultured cells. It also associates with class I HDACs., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N8S0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0007517 muscle organ development;GO:0045662 negative regulation of myoblast differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q96D98-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14592-1",
        "uniprot_id": "ZN460_HUMAN",
        "mass": 63665.0,
        "length": 562,
        "protein_name": "Zinc finger protein 460",
        "gene_name": "ZNF460",
        "organism": "Human",
        "refseq_name": "zinc finger protein 460 isoform 2",
        "refseq_ac": "NP_001317551",
        "gene_names_uniprotkb": "ZNF460; ZNF272",
        "gene_names_refseq": "HZF8; ZNF272; ZNF460",
        "protein_names_uniprotkb": "Zinc finger protein 460; Zinc finger protein 272; Zinc finger protein HZF8",
        "protein_names_refseq": "zinc finger protein 272; zinc finger protein 460 isoform 2; zinc finger protein HZF8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10794);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 81,
        "publication_id_list": "10235266;10330177;11237011;11395415;14519192;15004467;15175151;15896744;16606702;16719718;17525332;18669648;2163759;22645359;23481700;24715725;25218447;25576301;25755297;25772364;25880248;26024233;26375851;26992070;27862975;27920218;28228285;28514659;28832583;28834231;28904123;29242379;29437277;29493099;29557506;29632711;29786170;30315122;30379171;30410026;30429286;30524438;30833945;31154438;31217245;31530632;31844290;31848261;31937595;32157095;32161166;32357974;32387766;32488085;32502341;32938616;32983136;33123756;33392160;33633747;33717175;33912179;33968037;33981976;34171305;34738503;34932366;35051231;35318648;35561310;35580925;36241641;36284347;36563923;37057209;37938771;7865130;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis., [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]; Molecular cloning and tissue distribution of ZNF460., [RefSeq, PubMed]; ZNF460 mediates epithelial-mesenchymal transition to promote gastric cancer progression by transactivating APOC1 expression., [RefSeq, PubMed]; ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia Proliferation Via the NF-kappaB Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, May 2004]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4FU64;B4DNX9;Q2VPC7;Q6VSF8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "Q14592-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NEM0-1",
        "uniprot_id": "MCPH1_HUMAN",
        "mass": 92849.0,
        "length": 835,
        "protein_name": "Microcephalin",
        "gene_name": "MCPH1",
        "organism": "Human",
        "refseq_name": "microcephalin isoform 3",
        "refseq_ac": "NP_001166046",
        "gene_names_uniprotkb": "MCPH1",
        "gene_names_refseq": "BRIT1; MCPH1; MCT",
        "protein_names_uniprotkb": "Microcephalin",
        "protein_names_refseq": "BRCT-repeat inhibitor of TERT expression 1; microcephalin isoform 3",
        "tax_id": 9606,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); primary autosomal recessive microcephaly 1 (Disease Ontology:DOID:0070285); autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296); primary microcephaly (Disease Ontology:DOID:0070297); microcephaly (Disease Ontology:DOID:10907); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); renal carcinoma (Disease Ontology:DOID:4451)",
        "pathway": " (hsa:79648);  (R-HSA-2299718)",
        "pathway_count": 2,
        "publication_count": 62,
        "publication_id_list": "11237011;12046007;12086618;12208845;12571366;15199523;15220350;15750587;16211557;16479174;18204051;18211953;18367646;18452278;18669648;18718915;19925808;20068231;20551165;20551166;20622854;20966048;21498573;21515671;21911480;22139841;22154951;22908299;22952573;23186163;23498719;24714562;24715725;25301947;25576301;26154972;26728094;26992070;27846572;28218747;29437277;29557506;30410026;30429286;31844290;32157095;32502341;32938616;32983136;33203878;33298915;33592498;33717175;33936100;34171305;34561969;34705666;35051231;35281599;35456440;35580925;36284347",
        "class_list": "",
        "function": "Identification of Pathogenic Mutations in Primary Microcephaly- (MCPH-) Related Three Genes CENPJ, CASK, and MCPH1 in Consanguineous Pakistani Families. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of microcephalin, a protein implicated in determining the size of the human brain, which is mapped to the MCPH1 locus and is mutated in primary microcephaly., [RefSeq, PubMed]; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MCPH1 encodes different isoforms that are differentially regulated at the transcript level and have different functions at the protein level, [RefSeq, PubMed]; MCPH1, beyond its role deciding the brain size., [RefSeq, PubMed]; MCPH1: A Novel Case Report and a Review of the Literature. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Microcephalin and ASPM determine the size of the human brain, [RefSeq, PubMed]; This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A075B6F8;B4DWW2;E9PGU5;E9PH63;Q66GU1;Q9H9C7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0021987 cerebral cortex development;GO:0010468 regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q8NEM0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O94776-1",
        "uniprot_id": "MTA2_HUMAN",
        "mass": 75023.0,
        "length": 668,
        "protein_name": "Metastasis-associated protein MTA2",
        "gene_name": "MTA2",
        "organism": "Human",
        "refseq_name": "metastasis-associated protein MTA2 isoform 2",
        "refseq_ac": "NP_001317221",
        "gene_names_uniprotkb": "MTA2; MTA1L1; PID",
        "gene_names_refseq": "MTA1L1; MTA2; PID",
        "protein_names_uniprotkb": "Metastasis-associated protein MTA2; MTA1-L1 protein; Metastasis-associated 1-like 1; p53 target protein in deacetylase complex",
        "protein_names_refseq": "MTA1-L1 protein; metastasis -associated gene 1-like 1; metastasis associated gene family, member 2; metastasis-associated 1-like 1; metastasis-associated protein 2; metastasis-associated protein MTA2 isoform 2; metastasis-associated protein MTA2; p53 target protein in deacetylase complex",
        "tax_id": 9606,
        "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)",
        "pathway": " (hsa:9219);  (R-HSA-3214815);  (R-HSA-427389);  (R-HSA-6804758);  (R-HSA-73762);  (R-HSA-8943724);  (R-HSA-9679191);  (R-HSA-9843940);  (R-HSA-9844594);  (R-HSA-9845323);  (R-HSA-9937850);  (R-HSA-9940951);  (R-HSA-9976102)",
        "pathway_count": 13,
        "publication_count": 267,
        "publication_id_list": "10082553;10087012;10204490;10330177;10444591;10449787;10748112;10904264;10913176;10922406;10926844;10970879;10978333;11099047;11250901;11331609;11378386;11509652;11545734;11739383;11742974;11781575;11909966;11959841;11959846;12032298;12183469;12393749;12419226;12504854;12724404;12869583;14536086;15456747;1547496;15516265;15643425;15701600;15882967;16115318;16186106;16415179;16418168;16428440;16522641;16567619;16676006;16702404;16707490;16839880;16954381;17081983;17211407;17318177;17646674;17662961;17873065;17924679;17974977;18082607;18172008;18220336;18391013;18452278;18487508;18571423;18656484;18669648;18691976;18757745;18794358;18991276;19440552;19562805;19608861;19651622;19690332;19884659;20068230;20068231;20223979;20228809;20233713;2028256;20516213;20523938;20660729;21289308;21406692;21490301;21587264;21965678;22128185;22398447;22401777;22552008;22684280;22706990;22814904;22926524;23186163;23239876;23287862;23361464;23431171;23481700;23641311;24252660;24272870;24275569;24307175;24366607;24385926;24554700;24584101;24714562;24715725;24718924;24920672;25150861;25274305;25576301;25593309;25645385;25728608;25753662;25801024;25880248;25892735;26002965;26030138;26101246;26154972;26728094;26811146;26813693;26910647;26992070;27397612;27418187;27418309;27600516;27633282;27732854;27806305;27846572;27862975;27920218;2805069;28063628;28228285;28273063;28425720;28514659;28533432;28832583;28834231;28855257;28904123;28977666;29042441;29242379;29371260;29393594;29493099;29508533;29557506;29632046;29632711;29786170;29930882;29945920;30045876;30122475;30134174;30201761;30228260;30315122;30327463;30410026;30429286;30444036;30484775;30524438;30779550;30833945;30980593;31048504;31092671;31154438;31217245;31289231;31427381;31611695;31746185;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33123756;33141586;33214551;33264408;33283408;33298915;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34357683;34561969;34725712;34932366;35008409;35051231;35083852;35138101;35251023;35561310;35580925;35661819;36008597;36010968;36215666;36284347;36581221;37371463;37938771;38359823;38474064;38649186;38665916;39423807;40914422;7491500;7513682;7801123;7969165;8769649;9016654;9150135;9427644;9512513;9651585;9790534;9804427;9885572;9929979",
        "class_list": "",
        "function": "CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666)., [UniProtKB, PubMed, PubMed]; Prognostic, Immunological, and Mutational Analysis of MTA2 in Pan-Cancer and Drug Screening for Hepatocellular Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q68DB1;Q9UQB5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016020 membrane;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 27.0,
        "record_id": "O94776-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00634-1",
        "uniprot_id": "NET3_HUMAN",
        "mass": 61466.0,
        "length": 580,
        "protein_name": "Netrin-3",
        "gene_name": "NTN3",
        "organism": "Human",
        "refseq_name": "netrin-3 precursor",
        "refseq_ac": "NP_006172",
        "gene_names_uniprotkb": "NTN3; NTN2L",
        "gene_names_refseq": "NTN2L; NTN3",
        "protein_names_uniprotkb": "Netrin-3; Netrin-2-like protein",
        "protein_names_refseq": "Netrin-2, chicken, homolog of, like; Netrin-3; netrin-2-like protein; netrin-3 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4917);  (R-HSA-525793)",
        "pathway_count": 2,
        "publication_count": 21,
        "publication_id_list": "10.1101/2023.09.13.557529;10330143;10601328;10805738;11782431;12634428;19564926;20160094;21980448;28467828;29557506;29741879;35051231;39023520;8828041;9069290;9143507;9418854;9786951;9858528;9988769",
        "class_list": "",
        "function": "An autocrine function for netrin-1 and netrin-3 in U87 and U373 cells that slows migration, [RefSeq, PubMed]; Netrin signaling mediates survival of dormant epithelial ovarian cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; Netrins control guidance of CNS commissural axons and peripheral motor axons., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 9015,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007411 axon guidance",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "O00634-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P55884-1",
        "uniprot_id": "EIF3B_HUMAN",
        "mass": 92482.0,
        "length": 814,
        "protein_name": "Eukaryotic translation initiation factor 3 subunit B",
        "gene_name": "EIF3B",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 3 subunit B isoform 1",
        "refseq_ac": "NP_001032360",
        "gene_names_uniprotkb": "EIF3B; EIF3S9",
        "gene_names_refseq": "EIF3-ETA; EIF3-P110; EIF3-P116; EIF3B; EIF3S9; PRT1",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit B; Eukaryotic translation initiation factor 3 subunit 9; Prt1 homolog; eIF-3-eta; eIF3 p110; eIF3 p116; eIF3b; hPrt1",
        "protein_names_refseq": "eukaryotic translation initiation factor 3 subunit 9; eukaryotic translation initiation factor 3 subunit B isoform 1; eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD); eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa; protein synthesis 1; prt1 homolog",
        "tax_id": 9606,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); depressive disorder (Disease Ontology:DOID:1596)",
        "pathway": " (hsa:8662);  (R-HSA-156827);  (R-HSA-72649);  (R-HSA-72689);  (R-HSA-72695);  (R-HSA-72702);  (R-HSA-72706)",
        "pathway_count": 7,
        "publication_count": 172,
        "publication_id_list": "10364207;10659855;1095581;11018020;1104615;11169732;11237011;11457827;12042320;12493757;12588972;14519125;14567916;14688252;15104674;15302935;15592455;15703437;16286006;16322461;16408927;16766523;17081983;17190833;17322306;17322308;17468741;17581632;17984221;18056426;18212344;18220336;18452278;18491316;1856230;18599441;18628297;18669648;19413330;19415658;19608861;19651622;19664995;19690332;20058876;20068231;20166139;21406692;22223895;22645359;23186163;23301498;23481700;23719902;24275569;24366607;24423872;24714562;24715725;25418920;25502872;25576301;25645385;25849773;25880248;25892735;26154972;26375851;26728094;26811146;26853435;26929215;26992070;27117702;27462815;27846572;27920218;28063628;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29317506;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30397120;30410026;30429286;30484775;30524438;30779550;30833945;31020640;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33465208;33592498;33633747;33691108;33717175;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34509645;34561969;34725712;35008409;35051231;35138101;35154160;35251023;35318648;35561310;35580925;36010968;36050601;36241641;36284347;36581221;37217939;38665916;38687509;39302247;40596516;40914422;429297;592398;592399;641056;6853548;6901506;7000367;8943342;8995410;9045610;9388245;9732867;9857202",
        "class_list": "",
        "function": "(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426)., [UniProtKB, PubMed]; EIF3B stabilizes PCNA by counteracting SYVN1-mediated ubiquitination to serve as a promotor in cholangiocarcinoma., [RefSeq, PubMed]; EIF3B stabilizes PTGS2 expression by counteracting MDM2-mediated ubiquitination to promote the development and progression of malignant melanoma., [RefSeq, PubMed]; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D208;Q2NL77;Q9UMF9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003723 RNA binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0070062 extracellular exosome;GO:0010494 cytoplasmic stress granule;GO:0016282 eukaryotic 43S preinitiation complex",
        "go_biological_process": "GO:0075522 IRES-dependent viral translational initiation;GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0075525 viral translational termination-reinitiation",
        "synthesized_glycan_count": 0,
        "hit_score": 17.7,
        "record_id": "P55884-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O15121-1",
        "uniprot_id": "DEGS1_HUMAN",
        "mass": 37866.0,
        "length": 323,
        "protein_name": "Sphingolipid delta(4)-desaturase DES1",
        "gene_name": "DEGS1",
        "organism": "Human",
        "refseq_name": "sphingolipid delta(4)-desaturase DES1 isoform 1",
        "refseq_ac": "NP_003667",
        "gene_names_uniprotkb": "DEGS1; DES1; MIG15; MLD",
        "gene_names_refseq": "DEGS-1; DEGS1; DEGS; DES1; Des-1; FADS7; HLD18; MIG15; MLD",
        "protein_names_uniprotkb": "Sphingolipid delta(4)-desaturase DES1; 1.14.19.17; 5.2.1.-; Cell migration-inducing gene 15 protein; Degenerative spermatocyte homolog 1; Dihydroceramide desaturase-1; Membrane lipid desaturase; Retinol isomerase",
        "protein_names_refseq": "cell migration-inducing gene 15 protein; degenerative spermatocyte homolog 1, lipid desaturase; degenerative spermatocyte homolog, lipid desaturase; dihydroceramide desaturase 1; membrane fatty acid (lipid) desaturase; membrane lipid desaturase; migration-inducing gene 15 protein; retinol isomerase; sphingolipid delta 4 desaturase; sphingolipid delta(4)-desaturase 1; sphingolipid delta(4)-desaturase DES1 isoform 1",
        "tax_id": 9606,
        "disease": "hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786); hypomyelinating leukodystrophy 18 (Disease Ontology:DOID:0070399); neurodegenerative disease (Disease Ontology:DOID:1289); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:8560);  (R-HSA-1660661);  (R-HSA-6798695)",
        "pathway_count": 3,
        "publication_count": 135,
        "publication_id_list": "10722674;10751414;10802064;10947957;11237011;11937514;14685229;14685263;14976195;15063729;15328338;15337768;16100120;16118219;16571669;16793762;16895911;17023427;17050692;17283068;17331073;17355976;17449912;17591919;17982138;18165232;18165233;18184806;18669648;19005213;19233134;19416851;19506037;19647031;19748539;20061445;20105137;20110355;20182505;21620961;21914808;22424782;22517924;22544926;22970244;23143414;23180825;23481700;23602659;23650620;23754960;24569996;24715725;24782409;24958902;25255805;25576301;25645385;25788259;25892735;26154972;26375851;26811146;26992070;27397612;27846572;27862975;28510447;28575652;28904123;29437277;29493099;29557506;29563527;30410026;30429286;30484775;30620337;30620338;31186544;31217245;31844290;31895563;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33537174;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34561969;34932366;35051231;35318648;35409383;35561310;35580925;36010968;36184516;36215666;36241641;36284347;36902339;36907437;36951944;37224812;37390971;37890668;37938771;38342436;4339164;4817756;8692836;9188692;9312549;9363775",
        "class_list": "glycogene",
        "function": "Dihydroceramide Delta4-Desaturase 1 Is Not Involved in SARS-CoV-2 Infection., [RefSeq, PubMed]; Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (PubMed:11937514, PubMed:30620337, PubMed:30620338). Catalyzes the equilibrium isomerization of retinols (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Identification of sphingolipid delta 4-desaturase family, [RefSeq, PubMed]; Loss of function and reduced levels of sphingolipid desaturase DEGS1 variants are both relevant in disease mechanism., [RefSeq, PubMed]; Overexpression of DEGS1 or DEGS2 attenuates the DHC accumulation and increased cell proliferation during hypoxia Erratum:[J Biol Chem. 2012 May 18;287(21):17425], [RefSeq, PubMed]; Oxidative stress leads to potent inhibition of dihydroceramide desaturase resulting in significant elevation in dihydroceramide levels in vivo Publication Status: Online-Only, [RefSeq, PubMed]; Partial loss of DEGS-1 inhibited cell growth, with cell cycle arrest at G(0)/G(1). This was accompanied by a significant decrease in the amount of phosphorylated retinoblastoma protein, [RefSeq, PubMed]; Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity. Publication Status: Online-Only, [RefSeq, PubMed]; The atypical sphingolipid SPB 18:1(14Z);O2 is a biomarker for DEGS1 related hypomyelinating leukodystrophy., [RefSeq, PubMed]; This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 351,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "3.4.24.81;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;2.3.1.51;1.14.19.17;5.2.1.-;2.3.1.20;2.3.1.76;2.7.11.1;3.4.21.73;1.6.3.-;3.1.3.48;1.14.14.18;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;3.6.5.2;3.4.24.-;7.6.2.1;3.2.2.6;1.1.1.-;3.1.4.4;2.3.2.27;2.3.1.78;1.14.18.5",
        "go_molecular_function": "GO:0009055 electron transfer activity;GO:0042284 sphingolipid delta-4 desaturase activity;GO:0050251 retinol isomerase activity;GO:0016853 isomerase activity",
        "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.8,
        "record_id": "O15121-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6NXP0-1",
        "uniprot_id": "EFC12_HUMAN",
        "mass": 66551.0,
        "length": 572,
        "protein_name": "EF-hand calcium-binding domain-containing protein 12",
        "gene_name": "EFCAB12",
        "organism": "Human",
        "refseq_name": "EF-hand calcium-binding domain-containing protein 12",
        "refseq_ac": "NP_997190",
        "gene_names_uniprotkb": "EFCAB12; C3orf25",
        "gene_names_refseq": "C3orf25; EFCAB12",
        "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 12",
        "protein_names_refseq": "EF-hand calcium-binding domain-containing protein 12; EF-hand domain-containing protein C3orf25",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:90288)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;18491316;29557506;29632046;32938616;34509645;35051231;39894887",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
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        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
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        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q69YX4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q6NXP0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6QHC5-1",
        "uniprot_id": "DEGS2_HUMAN",
        "mass": 37197.0,
        "length": 323,
        "protein_name": "Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2",
        "gene_name": "DEGS2",
        "organism": "Human",
        "refseq_name": "sphingolipid delta(4)-desaturase/C4-monooxygenase DES2",
        "refseq_ac": "NP_996801",
        "gene_names_uniprotkb": "DEGS2; C14orf66",
        "gene_names_refseq": "C14orf66; DEGS2; DES2; FADS8",
        "protein_names_uniprotkb": "Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; 1.14.18.5; 1.14.19.17; Degenerative spermatocyte homolog 2; Sphingolipid 4-desaturase; Sphingolipid C4-monooxygenase",
        "protein_names_refseq": "degenerative spermatocyte homolog 2, lipid desaturase; dihydroceramide desaturase 2; sphingolipid 4-desaturase; sphingolipid C4-hydroxylase/delta 4-desaturase; sphingolipid C4-monooxygenase; sphingolipid delta 4 desaturase/C-4 hydroxylase; sphingolipid delta(4)-desaturase 2; sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2",
        "tax_id": 9606,
        "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:123099);  (R-HSA-1660661)",
        "pathway_count": 2,
        "publication_count": 71,
        "publication_id_list": "10722674;10751414;10802064;10947957;11237011;11937514;14685229;14685263;14976195;15063729;15328338;15337768;16100120;16118219;16571669;16793762;16895911;17023427;17050692;17331073;17355976;17449912;17591919;17982138;18165232;18165233;18184806;19005213;19233134;19416851;19506037;20061445;20110355;20182505;21620961;21914808;22517924;22970244;23180825;23602659;23754960;24569996;24782409;25788259;25871975;26992070;27862975;28228285;28575652;29393594;29557506;29563527;30833945;31844290;31848261;31895563;32157095;33537174;34171305;35051231;35409383;36284347;36902339;36907437;37224812;37390971;4339164;4817756;9188692;9312549;9363775",
        "class_list": "glycogene",
        "function": "Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides., [RefSeq, PubMed]; Bifunctional enzyme which acts both as a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase., [UniProtKB, PubMed]; DES2 was identified and its up-regulation followed during keratinocyte differentiation., [RefSeq, PubMed]; Findings demonstrate that a SNP showing genome-wide association study significant association with cognition in schizophrenia is also associated with regulation of DEGS2 expression, implicating a molecular mechanism for the clinical association. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression of DEGS1 or DEGS2 attenuates the DHC accumulation and increased cell proliferation during hypoxia Erratum:[J Biol Chem. 2012 May 18;287(21):17425], [RefSeq, PubMed]; This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 388,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6P492",
        "ec_number_list": "1.14.19.17;5.2.1.-;1.14.18.5",
        "go_molecular_function": "GO:0042284 sphingolipid delta-4 desaturase activity;GO:0102772 sphingolipid C4-monooxygenase activity",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006667 sphinganine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q6QHC5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O76036-1",
        "uniprot_id": "NCTR1_HUMAN",
        "mass": 34480.0,
        "length": 304,
        "protein_name": "Natural cytotoxicity triggering receptor 1",
        "gene_name": "NCR1",
        "organism": "Human",
        "refseq_name": "natural cytotoxicity triggering receptor 1 isoform b precursor",
        "refseq_ac": "NP_001138929",
        "gene_names_uniprotkb": "NCR1; LY94",
        "gene_names_refseq": "CD335; LY94; NCR1; NK-p46; NKP46",
        "protein_names_uniprotkb": "Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; NK-p46; NKp46; Natural killer cell p46-related protein; hNKp46",
        "protein_names_refseq": "NK cell-activating receptor; NK-p46); lymphocyte antigen 94 homolog (activating NK-receptor; natural cytotoxicity triggering receptor 1 isoform b precursor; natural killer cell p46-related protein",
        "tax_id": 9606,
        "disease": "lymphoproliferative syndrome (Disease Ontology:DOID:0060704); anogenital venereal wart (Disease Ontology:DOID:11168); hepatitis C (Disease Ontology:DOID:1883); acquired immunodeficiency syndrome (Disease Ontology:DOID:635)",
        "pathway": " (hsa:9437);  (R-HSA-198933)",
        "pathway_count": 2,
        "publication_count": 93,
        "publication_id_list": "10499918;10746781;11237011;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11907104;11955593;11955595;11955599;12213321;12483297;12588680;12951052;12960161;14719373;14754506;14970179;15034010;15136729;15155468;15187158;15304001;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;16014749;16091383;16129954;16339513;16380601;16551255;16737824;16754721;16893496;16904340;16928187;16959974;17045824;17057721;17237375;17337780;18031695;18037897;18055229;18209062;18234675;18593354;19149696;19359216;19592130;20147410;20730098;21241660;21800138;21841309;21849674;21877119;22396535;23695528;23929856;24305946;25703557;25716998;26284469;26300885;28218747;28834231;30315122;33368832;33930666;34464905;37020026;39137897;7531291;7542404;8178173;8995416;9285412;9314561;9700512;9730896",
        "class_list": "",
        "function": "Amplification of autoimmune organ damage by NKp46-activated ILC1s., [RefSeq, PubMed]; Co-expression of NKp46 with activating or inhibitory receptors on, and cytokine production by, uterine endometrial NK cells in recurrent pregnancy loss., [RefSeq, PubMed]; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Expression of natural cytotoxicity receptor NKp46 on peripheral blood natural killer cells in women with a history of recurrent implantation failures., [RefSeq, PubMed]; NK cells that differ in expression of NKp46 might play different roles in endometrium., [RefSeq, PubMed]; The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells. Erratum:[Nature. 2023 Jun;618(7964):E17. doi: 10.1038/s41586-023-06151-z. PMID: 37198495], [RefSeq, PubMed]; The NKp46 receptor participates in NK cell-mediated lysis of cells infected with the intracellular pathogen Mycobacterium tuberculosis, an activity that is reduced in tuberculosis patients compared with findings in healthy donors., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 3,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 2,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0V3L2;B0V3L3;B0V3L4;B0V3L5;B8JL03;O76016;O76017;O76018",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0140375 immune receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016514 SWI/SNF complex",
        "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0007165 signal transduction;GO:0006968 cellular defense response;GO:0030101 natural killer cell activation;GO:0042269 regulation of natural killer cell mediated cytotoxicity",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "O76036-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96JP2-1",
        "uniprot_id": "MY15B_HUMAN",
        "mass": 338187.0,
        "length": 3096,
        "protein_name": "Unconventional myosin-XVB",
        "gene_name": "MYO15B",
        "organism": "Human",
        "refseq_name": "myosin XVB isoform 2",
        "refseq_ac": "NP_001296171",
        "gene_names_uniprotkb": "MYO15B; KIAA1783; MYO15BP",
        "gene_names_refseq": "MYO15BP; MYO15B",
        "protein_names_uniprotkb": "Unconventional myosin-XVB; Myosin XVBP; Unconventional myosin-15B",
        "protein_names_refseq": "myosin XVB isoform 2; myosin XVB pseudogene; unconventional myosin XVBP pseudogene",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80022)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;11294886;11964073;23481700;30192525;30833945",
        "class_list": "",
        "function": "Myosin XVBP is a transcribed pseudogene (myosin XVBP=MYO15BP), [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
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        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0J9YVZ6;A0A2R8YFM0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0003774 cytoskeletal motor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005903 brush border;GO:0016459 myosin complex;GO:0120025 plasma membrane bounded cell projection;GO:0005856 cytoskeleton",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q96JP2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9ULC0-1",
        "uniprot_id": "MUCEN_HUMAN",
        "mass": 27452.0,
        "length": 261,
        "protein_name": "Endomucin",
        "gene_name": "EMCN",
        "organism": "Human",
        "refseq_name": "endomucin isoform 2 precursor",
        "refseq_ac": "NP_001153166",
        "gene_names_uniprotkb": "EMCN; EMCN2; MUC14",
        "gene_names_refseq": "EMCN2; EMCN; MUC14",
        "protein_names_uniprotkb": "Endomucin; Endomucin-2; Gastric cancer antigen Ga34; MUC-14; Mucin-14",
        "protein_names_refseq": "MUC-14; endomucin isoform 2 precursor; endomucin-2; gastric cancer antigen Ga34; mucin-14",
        "tax_id": 9606,
        "disease": "thyroid gland carcinoma (Disease Ontology:DOID:3963)",
        "pathway": " (hsa:51705)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;11418125;12485444;14722670;29485866;30459171;31154438;32517158;34828282;36215666;38605348;39153592",
        "class_list": "",
        "function": "EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001 [PubMed 11418125]).[supplied by OMIM, Mar 2008]., [RefSeq]; Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity. Publication Status: Online-Only, [RefSeq, PubMed]; Endomucin selectively regulates vascular endothelial growth factor receptor-2 endocytosis through its interaction with AP2. Erratum:[Cell Commun Signal. 2024 Jun 6;22(1):311. doi: 10.1186/s12964-024-01696-6. PMID: 38844932] Publication Status: Online-Only, [RefSeq, PubMed]; Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix., [UniProtKB]; MUC14-Related ncRNA-mRNA Network in Breast Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Non-endothelial expression of endomucin in the mouse and human choroid., [RefSeq, PubMed]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 12,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 12,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 12,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 1,
        "glyco_site_count": 18,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K716;B4E347;Q8NEY5;Q8WWE7;Q9NRM8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q9ULC0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UK23-1",
        "uniprot_id": "NAGPA_HUMAN",
        "mass": 56073.0,
        "length": 515,
        "protein_name": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase",
        "gene_name": "NAGPA",
        "organism": "Human",
        "refseq_name": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor",
        "refseq_ac": "NP_057340",
        "gene_names_uniprotkb": "NAGPA",
        "gene_names_refseq": "APAA; NAGPA; UCE",
        "protein_names_uniprotkb": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; 3.1.4.45; Mannose 6-phosphate-uncovering enzyme; Phosphodiester alpha-GlcNAcase",
        "protein_names_refseq": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor; alpha-N-acetylglucosaminyl phosphodiesterase; lysosomal alpha-N-acetylglucosaminidase; mannose 6-phosphate-uncovering enzyme; phosphodiester alpha-GlcNAcase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51172)",
        "pathway_count": 1,
        "publication_count": 38,
        "publication_id_list": "10.1101/2023.09.13.557529;10551838;11237011;12058031;20147709;21956109;22884963;23572527;24190977;25502872;25505266;26544806;27600516;28904123;29242379;29289611;29393594;29557506;29786170;30429286;31003007;31154438;31217245;31530632;31844290;32109365;32350084;32488085;32983136;33141586;33912179;33936100;33993232;34171305;34357683;35051231;35154160;35251023",
        "class_list": "glycogene",
        "function": "14 variations were found in GNPTAB, GNPTG and NAGPA genes., [RefSeq, PubMed]; Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases., [UniProtKB, PubMed]; Crystal Structure of the Mannose-6-Phosphate Uncovering Enzyme., [RefSeq, PubMed]; Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients. [provided by RefSeq, Oct 2015]., [RefSeq]; Identification of a shared genetic risk locus for Kawasaki disease and immunoglobulin A vasculitis by a cross-phenotype meta-analysis., [RefSeq, PubMed]; To date mutations in GNPTAB, GNPTG, and NAGPA have been associated with stuttering. These genes encode the lysosomal enzyme targeting pathway, defective in mucolipidosis. (Review) Review article, [RefSeq, PubMed]; We evaluated 51 stuttering individuals with a mutation in either the GNPTAB, GNPTG, NAGPA, or AP4E1 gene. Mutation carriers achieved significantly less resolution in PSI following therapy, with PSI scores showing significantly less improvement in individuals who carry a mutation (p = 0.0157, RR = 1.75, OR = 2.92) while the group difference in DWS between carriers and non-carriers was statistically not significant., [RefSeq, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 19,
        "reported_glycation": 0,
        "reported_snv": 837,
        "reported_interactions": 0,
        "missing_score": 9641,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RAS1;Q96EJ8",
        "ec_number_list": "3.1.4.45",
        "go_molecular_function": "GO:0003944 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0032580 Golgi cisterna membrane",
        "go_biological_process": "GO:0036211 protein modification process;GO:0005975 carbohydrate metabolic process;GO:0007040 lysosome organization;GO:0006622 protein targeting to lysosome;GO:0033299 secretion of lysosomal enzymes",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q9UK23-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P40937-1",
        "uniprot_id": "RFC5_HUMAN",
        "mass": 38497.0,
        "length": 340,
        "protein_name": "Replication factor C subunit 5",
        "gene_name": "RFC5",
        "organism": "Human",
        "refseq_name": "replication factor C subunit 5 isoform 3",
        "refseq_ac": "NP_001123584",
        "gene_names_uniprotkb": "RFC5",
        "gene_names_refseq": "RFC36; RFC5",
        "protein_names_uniprotkb": "Replication factor C subunit 5; A1 36 kDa subunit; Activator 1 36 kDa subunit; Activator 1 subunit 5; RF-C 36 kDa subunit; RFC36; Replication factor C 36 kDa subunit",
        "protein_names_refseq": "A1 36 kDa subunit; RF-C 36 kDa subunit; RFC, 36.5 kD subunit; replication factor C (activator 1) 5, 36.5kDa; replication factor C subunit 5 isoform 3; replication factor C, 36-kDa subunit",
        "tax_id": 9606,
        "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)",
        "pathway": " (hsa:5985);  (R-HSA-110312);  (R-HSA-110314);  (R-HSA-110320);  (R-HSA-174411);  (R-HSA-176187);  (R-HSA-5651801);  (R-HSA-5655862);  (R-HSA-5656121);  (R-HSA-5656169);  (R-HSA-5685938);  (R-HSA-5685942);  (R-HSA-5693537);  (R-HSA-5693607);  (R-HSA-5693616);  (R-HSA-5696397);  (R-HSA-5696400);  (R-HSA-6782135);  (R-HSA-6782210);  (R-HSA-6804756);  (R-HSA-69091);  (R-HSA-69473);  (R-HSA-9709570)",
        "pathway_count": 23,
        "publication_count": 342,
        "publication_id_list": "10.1101/2023.09.13.557529;10051570;10212258;10329413;10373362;10373512;10435622;10438626;10460157;10500146;10536157;10551859;10559261;10570149;10570174;10604467;10656791;10656792;10660610;10673500;10673501;10710310;10733923;10744741;10744977;10751307;10760286;10777662;10801132;10827953;10856253;10859164;10884347;10887153;10921897;10959839;10984059;11006276;11058110;11080452;11139606;11237011;11239457;11250913;11301010;11376695;11390642;11447225;11485998;11511362;11546806;11551930;11571269;11572977;11601988;11687589;11698410;11740489;11751635;11780126;11784855;11832208;11917024;12064478;12139939;12145297;12152085;12191481;12200445;12226092;12226657;12228710;12370410;12379650;12393879;12399544;12444249;12545175;12578958;12584190;12676583;12676925;12702766;12750383;12759351;12766176;12791985;12851404;12914926;12930902;12952891;12963847;14500360;14517266;14576433;14603323;14605214;14624239;14657033;14702041;14734547;15053879;15066120;15149598;15189136;15189446;15190204;15199127;15226314;15254543;15359272;15475561;15485900;15590680;15657443;15665856;15703751;15707391;15743907;15833913;15866171;15916957;16139798;16148040;16153896;16246722;16322561;16327781;16337601;16344468;16357261;16360315;16407120;16464020;16530042;16531995;16611994;1671046;16819516;1682322;16885023;17000769;17043239;17108107;17349958;17466625;17466626;17515903;17517887;17575048;17591690;17720710;17928296;17948053;17962301;17965729;18079701;18171670;18242152;18317453;18342608;18480045;18490454;18539610;18541667;18757400;18805091;18923075;18971343;19074197;19121998;19153606;19170759;19223468;19279666;19357644;19419957;19492058;1974050;19940136;19941829;19965871;20008555;20129063;20154705;20159558;20159559;20164194;20227374;20233725;20660785;20729832;20729858;20729859;20934997;20952260;20959462;20965415;21052091;21143968;21240188;21263215;21282463;21317932;21325134;21335604;21565612;21628590;2165567;21659603;21680713;21777809;21791603;21804533;22021381;22024395;22081108;22194698;22231403;22424782;22544926;22635276;22661229;22661230;22681887;22700975;22721435;22772988;22792074;22859295;22859296;22902628;22952233;22977173;23000554;23000965;23042605;23042607;23143872;23149936;23301498;23345434;23468639;23485397;23593430;23676219;23686288;23731732;23810717;24013206;24038470;24115439;24145406;24402227;24449906;24485656;24648516;24715725;24768535;24874608;25113031;25122754;25558984;25576301;25659039;26145171;26154972;26992070;28510447;28904123;29493099;29557506;30429286;30484775;31217245;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33912179;33936100;33968037;33978741;33981976;34019948;34087483;34171305;34211107;34405274;34440403;34509645;34561969;34932366;35051231;35544695;35561310;35580925;36010968;36172813;36215666;36241641;36988339;3941892;7378348;7700386;7713898;8078911;8104944;8196638;8441605;8658138;8702565;8751446;8943031;8954124;8999859;9191022;9214649;9278511;9278512;9488738;9649448;9660172;9699634;9705271;9716411;9780000;9822671;9837724;9875289;9925639",
        "class_list": "",
        "function": "Prognostic biomarker replication factor C subunit 5 and its correlation with immune infiltrates in acute myeloid leukemia., [RefSeq, PubMed]; RFC5, regulated by circ_0038985/miR-3614-5p, functions as an oncogene in the progression of colorectal cancer., [RefSeq, PubMed]; Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA., [UniProtKB, PubMed, PubMed]; This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MZ62;B3KSX8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0016887 ATP hydrolysis activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031390 Ctf18 RFC-like complex;GO:0005663 DNA replication factor C complex",
        "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0006261 DNA-templated DNA replication",
        "synthesized_glycan_count": 0,
        "hit_score": 34.7,
        "record_id": "P40937-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96KS0-1",
        "uniprot_id": "EGLN2_HUMAN",
        "mass": 43650.0,
        "length": 407,
        "protein_name": "Prolyl hydroxylase EGLN2",
        "gene_name": "EGLN2",
        "organism": "Human",
        "refseq_name": "prolyl hydroxylase EGLN2",
        "refseq_ac": "NP_444274",
        "gene_names_uniprotkb": "EGLN2; EIT6",
        "gene_names_refseq": "EGLN2; EIT-6; EIT6; HIF-PH1; HIFPH1; HPH-1; HPH-3; PHD1",
        "protein_names_uniprotkb": "Prolyl hydroxylase EGLN2; 1.14.11.-; 1.14.11.29; EIT-6; Egl nine homolog 2; Estrogen-induced tag 6; HIF-PH1; HIF-prolyl hydroxylase 1; HPH-1; HPH-3; Hypoxia-inducible factor prolyl hydroxylase 1; PHD1; Prolyl hydroxylase domain-containing protein 1",
        "protein_names_refseq": "HIF-prolyl hydroxylase 1; egl nine homolog 2; estrogen-induced tag 6; hypoxia-inducible factor prolyl hydroxylase 1; prolyl hydroxylase EGLN2; prolyl hydroxylase domain-containing protein 1",
        "tax_id": 9606,
        "disease": "renal cell carcinoma (Disease Ontology:DOID:4450)",
        "pathway": " (hsa:112398);  (R-HSA-1234176)",
        "pathway_count": 2,
        "publication_count": 92,
        "publication_id_list": "10535940;10823831;10878807;10944113;10973499;11024059;11237011;11292861;11292862;11358837;11454738;11504942;11574160;11595178;11595184;11598268;11850811;12039559;12101228;12163023;12181324;12351678;12538644;12615973;12788921;12821933;12912907;15247232;15474027;15652751;15925519;15987702;16509823;16738327;17114296;17182618;17434750;18184961;18337469;18710826;19208626;19339211;19631610;21335549;21410436;22286099;23186163;23932902;24714562;24715725;25576301;25645385;26644182;26992070;27263528;27600516;27846572;28063628;28594552;28832583;28834231;29242379;29393594;29485866;29493099;29557506;29632046;30429286;30524438;30833945;31154438;31500697;31729379;31844290;31848261;32157095;32387766;32458625;32897882;33141586;33392160;34087483;34171305;34509645;34932366;35051231;35580925;36284347;37847687;38360997;9122164;9891082",
        "class_list": "",
        "function": "Adenylosuccinate lyase (ADSL) is an EglN2 hydroxylase substrate in triple negative breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Association of EGLN2 rs10680577 Polymorphism with the Risk and Clinicopathological Features of Patients with Prostate Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Defines the existence of two species of PHD1 and provide evidence that they are generated by alternative translational initiation, [RefSeq, PubMed]; Loss of prolyl hydroxylase 1 and 2 in SM22alpha-expressing cells prevents Hypoxia-Induced pulmonary hypertension., [RefSeq, PubMed]; Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; The authors did not detect prolyl-hydroxylase activity on any reported non-HIF protein or peptide, using conditions supporting robust HIF-alpha hydroxylation. Publication Status: Online-Only, [RefSeq, PubMed]; The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011]., [RefSeq]; VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5S0;Q8WWY4;Q9BV14",
        "ec_number_list": "1.14.11.-;1.14.11.29",
        "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0031418 L-ascorbic acid binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0031545 peptidyl-proline 4-dioxygenase activity;GO:0019826 oxygen sensor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0001666 response to hypoxia;GO:0071456 cellular response to hypoxia;GO:0001558 regulation of cell growth;GO:0045454 cell redox homeostasis;GO:0045732 positive regulation of protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q96KS0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00160-1",
        "uniprot_id": "MYO1F_HUMAN",
        "mass": 124844.0,
        "length": 1098,
        "protein_name": "Unconventional myosin-If",
        "gene_name": "MYO1F",
        "organism": "Human",
        "refseq_name": "unconventional myosin-If isoform 1",
        "refseq_ac": "NP_036467",
        "gene_names_uniprotkb": "MYO1F",
        "gene_names_refseq": "MYO1F",
        "protein_names_uniprotkb": "Unconventional myosin-If; Myosin-Ie",
        "protein_names_refseq": "myosin-ID; myosin-Ie; unconventional myosin-If isoform 1; unconventional myosin-If",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4542)",
        "pathway_count": 1,
        "publication_count": 62,
        "publication_id_list": "11237011;11804589;17081983;19027848;19367720;20068231;22938506;23481700;25418920;25469497;25645385;25880248;25892735;26154972;26375851;26992070;27846572;27862975;28904123;29493099;29557506;30315122;30429286;30779550;30833945;31092671;31154438;31222486;31245869;31530632;31844290;31848261;31998317;32161166;32265295;32357974;32387766;32502341;32897882;32938616;32983136;33123756;33141586;33392160;33912179;33941653;33968037;34019948;34211107;34357683;34509645;34932366;35051231;35318648;35494241;35580925;36215666;36284347;37938771;39276460;40914422;9119401",
        "class_list": "",
        "function": "Identification of 6 heterozygous missense mutations in MYO1C and additional 5 heterozygous missense mutations in MYO1F in bilateral sensorineural hearing loss GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis. Erratum:[J Immunol. 2021 Dec 1;207(11):2894. doi: 10.4049/jimmunol.2100908. PMID: 34716186], [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)., [UniProtKB]; Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]., [RefSeq]; NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co-expression network analysis., [RefSeq, PubMed]; Role of MYO1F in neutrophil and macrophage recruitment and pro-inflammatory cytokine production in Aspergillus fumigatus keratitis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WWN7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005902 microvillus",
        "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "O00160-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q29980-1",
        "uniprot_id": "MICB_HUMAN",
        "mass": 42575.0,
        "length": 383,
        "protein_name": "MHC class I polypeptide-related sequence B",
        "gene_name": "MICB",
        "organism": "Human",
        "refseq_name": "MHC class I polypeptide-related sequence B isoform 2",
        "refseq_ac": "NP_001276089",
        "gene_names_uniprotkb": "MICB; PERB11.2",
        "gene_names_refseq": "MICB; PERB11.2",
        "protein_names_uniprotkb": "MHC class I polypeptide-related sequence B; MIC-B",
        "protein_names_refseq": "MHC class I antigen-related protein B; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I polypeptide-related sequence B isoform 2; MHC class I-like molecule PERB11.2-IMX; stress inducible class I homolog",
        "tax_id": 9606,
        "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148)",
        "pathway": " (hsa:4277);  (R-HSA-198933)",
        "pathway_count": 2,
        "publication_count": 143,
        "publication_id_list": "10359807;10499918;10746781;10746790;11237011;11239445;11265639;11287116;11489943;11491531;11513152;11556966;11777960;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12133964;12213321;12466900;12483297;12538683;12569559;12588680;12782710;14719373;14970179;15034010;15136729;15155468;15187158;15191526;15304001;15304008;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;16014749;16091383;16129954;16339513;16380601;16551255;16698441;16737824;16754721;16849432;16893496;16904340;16928187;17003176;17045824;17057721;17237375;17337780;17561376;17565371;17641203;17678727;18031695;18037897;18055229;18209062;18234675;18395517;18593354;19149696;19359216;19592130;20730098;21241660;21800138;21841309;21877119;22396535;23090970;23695528;23929856;24190977;24305946;25418920;25576301;25703557;25716998;26284469;26300885;26992070;28218747;28228285;28832583;28834231;29242379;29393594;29632046;30315122;30429286;32153595;32157095;32938616;32983136;33298915;33592498;33691108;33968037;33981976;34357683;34509645;34932366;35051231;35251023;35580925;36241641;36284347;36898046;36958849;37878820;38205878;38253038;38847554;7531291;7542404;8178173;8575823;8952966;8995188;8995416;9271635;9285412;9314561;9321430;9497295;9694358;9700512;9730896",
        "class_list": "",
        "function": "Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC)., [RefSeq, PubMed]; Clinical Significance of Plasma Soluble MICB in Children With EBV-associated Hemophagocytic Lymphohistiocytosis., [RefSeq, PubMed]; Linc-ROR inhibits NK cell-killing activity by promoting RXRA ubiquitination and reducing MICB expression in gastric cancer patients., [RefSeq, PubMed]; MICB Genetic Variants and Its Protein Soluble Level Are Associated with the Risk of Chronic GvHD and CMV Infection after Allogeneic HSCT. Publication Status: Online-Only, [RefSeq, PubMed]; MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death., [RefSeq, PubMed]; This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]., [RefSeq]; Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells (PubMed:11491531, PubMed:11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2AC57;A6NP85;B0UZ10;B2RAK2;O14499;O14500;O19798;O19799;O19800;O19801;O19802;O19803;O78099;O78100;O78101;O78102;O78103;O78104;P79525;P79541;Q5GR31;Q5GR37;Q5GR41;Q5GR42;Q5GR43;Q5GR44;Q5GR46;Q5GR48;Q5RIY6;Q5SSK1;Q5ST25;Q7JK51;Q7YQ89;Q861E6;Q9MY18;Q9MY19;Q9MY20;Q9UBH4;Q9UBZ8;Q9UEJ0;X6R344",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0050689 negative regulation of defense response to virus by host;GO:0006955 immune response;GO:0006979 response to oxidative stress;GO:0032526 response to retinoic acid;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 14.8,
        "record_id": "Q29980-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14515-1",
        "uniprot_id": "SPRL1_HUMAN",
        "mass": 75208.0,
        "length": 664,
        "protein_name": "SPARC-like protein 1",
        "gene_name": "SPARCL1",
        "organism": "Human",
        "refseq_name": "SPARC-like protein 1 isoform 1 precursor",
        "refseq_ac": "NP_001121782",
        "gene_names_uniprotkb": "SPARCL1",
        "gene_names_refseq": "MAST 9; MAST9; PIG33; SC1; SPARCL1",
        "protein_names_uniprotkb": "SPARC-like protein 1; Hevin; High endothelial venule protein; MAST 9",
        "protein_names_refseq": "SPARC-like 1 (hevin); SPARC-like protein 1 isoform 1 precursor; SPARC-like protein 1; high endothelial venule protein; proliferation-inducing protein 33",
        "tax_id": 9606,
        "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)",
        "pathway": " (hsa:8404);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 3,
        "publication_count": 97,
        "publication_id_list": "40667337;10.1021/acs.analchem.6b02887;10026136;10077652;10218588;10512690;10614670;10681634;10810289;10898936;10912521;10951195;10990447;11158056;11237011;11250653;11264294;11316783;11522292;11606061;11739083;11751371;11788658;12241545;12379487;12466191;12810533;12904166;1370451;1383255;15126567;15308688;15469690;15485880;15525596;15642270;16335952;17047378;17249697;17312271;17985932;18566446;18702456;19117535;19531498;19824718;19838169;20187088;21081667;23090970;23234360;2476804;2479552;26091039;28035807;28832583;29557506;30237853;30429286;30459171;31154438;31848261;32125861;32157095;32387766;33592498;34932366;35051231;35136209;35494241;35549806;35580925;36830603;37074911;37180578;38762489;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7600298;7683646;7689487;8781553;8817670;8894645;8964575;9497324;9709957;9733769;9786878;9922210",
        "class_list": "",
        "function": "Circular_0086414 induces SPARC like 1 (SPARCL1) production to inhibit esophageal cancer cell proliferation, invasion and glycolysis and induce cell apoptosis by sponging miR-1290., [RefSeq, PubMed]; Identifying liver metastasis-related hub genes in breast cancer and characterizing SPARCL1 as a potential prognostic biomarker. Publication Status: Online-Only, [RefSeq, PubMed]; The KDM6A-SPARCL1 axis blocks metastasis and regulates the tumour microenvironment of gastrointestinal stromal tumours by inhibiting the nuclear translocation of p65., [RefSeq, PubMed]; The Matricellular Protein Hevin Is Involved in Alcohol Use Disorder. Publication Status: Online-Only, [RefSeq, PubMed]; Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 6,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 13,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 14,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 14,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 19,
        "disease_count": 1,
        "glyco_site_count": 20,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E2Z0;E7ESU2;Q14800",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0007165 signal transduction;GO:0099560 synaptic membrane adhesion;GO:0050807 regulation of synapse organization",
        "synthesized_glycan_count": 0,
        "hit_score": 13.4,
        "record_id": "Q14515-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H9B1-1",
        "uniprot_id": "EHMT1_HUMAN",
        "mass": 141466.0,
        "length": 1298,
        "protein_name": "Histone-lysine N-methyltransferase EHMT1",
        "gene_name": "EHMT1",
        "organism": "Human",
        "refseq_name": "histone-lysine N-methyltransferase EHMT1 isoform 2",
        "refseq_ac": "NP_001138999",
        "gene_names_uniprotkb": "EHMT1; EUHMTASE1; GLP; KIAA1876; KMT1D",
        "gene_names_refseq": "EHMT1-IT1; EHMT1; EUHMTASE1; Eu-HMTase1; FP13812; GLP1; GLP; KLEFS1; KMT1D",
        "protein_names_uniprotkb": "Histone-lysine N-methyltransferase EHMT1; 2.1.1.-; 2.1.1.367; Eu-HMTase1; Euchromatic histone-lysine N-methyltransferase 1; G9a-like protein 1; GLP1; GLP; H3-K9-HMTase 5; Histone H3-K9 methyltransferase 5; Lysine N-methyltransferase 1D",
        "protein_names_refseq": "EHMT1 intronic transcript 1; G9a-like protein 1; H3-K9-HMTase 5; euchromatic histone-lysine N-methyltransferase 1; histone H3-K9 methyltransferase 5; histone-lysine N-methyltransferase EHMT1 isoform 2; histone-lysine N-methyltransferase EHMT1; histone-lysine N-methyltransferase, H3 lysine-9 specific 5; lysine N-methyltransferase 1D",
        "tax_id": 9606,
        "disease": "Kleefstra syndrome 1 (Disease Ontology:DOID:0060352); Kleefstra syndrome (Disease Ontology:DOID:0080597); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); viral infectious disease (Disease Ontology:DOID:934)",
        "pathway": " (hsa:79813);  (R-HSA-2559582);  (R-HSA-3214841);  (R-HSA-6804760);  (R-HSA-8853884);  (R-HSA-8953750);  (R-HSA-9843970)",
        "pathway_count": 7,
        "publication_count": 191,
        "publication_id_list": "10.1101/2023.09.13.557529;10201372;10318916;10432220;10518217;10548110;10949293;11114305;11171983;11237011;11340163;11511361;11959841;12004135;12123582;12130538;12453418;12540855;12670868;12832467;12909625;14536086;14679213;14690610;14992727;15014447;15145825;15235609;15448695;15525938;15536069;15774718;15805155;15964846;16118227;16199523;16292313;16415881;16501248;16519522;16626623;16682010;16702210;16805913;16826528;16959974;17001316;17021013;17081983;17108971;17170761;17500065;17525332;17544230;17600109;17707229;17707234;18172012;18264113;18267069;18411265;18452278;18555777;18555778;18562691;18669648;18833288;19011621;19061646;19264732;19691289;19805069;19808676;20028861;20068231;20084102;20118233;20351173;20434463;20452968;20870725;20871592;21131967;21196496;21325273;21515635;21596310;21625555;21670496;21779408;2183031;21832073;21979375;22022377;22099308;22178396;22362889;22634325;22658674;22939622;23186163;23301498;23481700;23846687;23954429;2405250;24275569;24627085;24706756;24714562;24715725;25114211;25218447;25418920;25489052;25576301;25645385;25755297;25772364;26022416;26154972;26375851;26728094;26791533;26992070;27732843;27846572;27920218;28063628;28581500;28832583;28834231;29211708;29242379;29393594;29508533;29557506;29632046;29632711;29728366;29786170;30315122;31154438;31530632;31844290;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32938616;32976585;32983136;33009411;33141586;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34171305;34185709;34211107;34509645;34954891;35051231;35251023;35580925;36010968;36284347;37257768;37663929;37894922;37938771;7623816;8234276;8384717;8413215;8413306;8617720;8688489;8884985;8939459;9501179;9689056;9704927",
        "class_list": "",
        "function": "Cell consequences of loss of function of the epigenetic factor EHMT1., [RefSeq, PubMed]; Demethylation of EHMT1/GLP Protein Reprograms Its Transcriptional Activity and Promotes Prostate Cancer Progression. Publication Status: Online-Only, [RefSeq, PubMed]; EHMT1/EHMT2 in EMT, cancer stemness and drug resistance: emerging evidence and mechanisms. Review article, [RefSeq, PubMed]; Haploinsufficiency of EHMT1 is causative for 9q subtelomeric deletion syndrome., [RefSeq, PubMed]; Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma. Publication Status: Online-Only, [RefSeq, PubMed]; Histone methyltransferase that specifically mono-, di- and trimethylates 'Lys-9' of histone H3 (H3K9me1, H3K9me2 and H3K9me3, respectively) in euchromatin (PubMed:12004135). H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones (PubMed:12004135). Also weakly methylates 'Lys-27' of histone H3 (H3K27me) (PubMed:12004135). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently (By similarity). Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1 (PubMed:12004135). During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle (PubMed:12004135). Involved in the differentiation of myoblastic precursors into brown adipose cells: following recruitment to chromatin by PRDM16, mediates formation of H3K9me2 and H3K9me3, inhibiting the expression of white adipose-selective genes (By similarity). Also involved in the differentiation of beige adipocytes from white adipose cells following recruitment by PRDM16 (By similarity). EHMT1 also promotes protein stabilization of PRDM16, by preventing PRDM16 ubiquitination and degradation (By similarity). In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53 (PubMed:20118233). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]., [RefSeq]; This indicates that haploinsufficiency of Eu-HMTase1 is responsible for the 9q submicroscopic subtelomeric deletion syndrome, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 49,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 4,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AQ58;B1AQ59;Q86X08;Q8TCN7;Q96F53;Q96JF1;Q96KH4",
        "ec_number_list": "2.3.2.24;2.3.2.23;2.1.1.-;2.1.1.367;2.3.2.27;2.1.1.366;2.1.1.359",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008168 methyltransferase activity;GO:0002039 p53 binding;GO:0016279 protein-lysine N-methyltransferase activity;GO:0046974 histone H3K9 methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0005694 chromosome",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0050873 brown fat cell differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0050821 protein stabilization;GO:0006325 chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 19.9,
        "record_id": "Q9H9B1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60237-1",
        "uniprot_id": "MYPT2_HUMAN",
        "mass": 110404.0,
        "length": 982,
        "protein_name": "Protein phosphatase 1 regulatory subunit 12B",
        "gene_name": "PPP1R12B",
        "organism": "Human",
        "refseq_name": "protein phosphatase 1 regulatory subunit 12B isoform e",
        "refseq_ac": "NP_001161329",
        "gene_names_uniprotkb": "PPP1R12B; MYPT2",
        "gene_names_refseq": "M20; MYPT2; PP1bp55; PPP1R12B",
        "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 12B; Myosin phosphatase target subunit 2; Myosin phosphatase-targeting subunit 2",
        "protein_names_refseq": "myosin phosphatase target subunit 2; myosin phosphatase-targeting subunit 2; protein phosphatase 1 regulatory subunit 12B isoform e; protein phosphatase 1, regulatory (inhibitor) subunit 12B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4660);  (R-HSA-5625740);  (R-HSA-5625900);  (R-HSA-5627117);  (R-HSA-5627123)",
        "pathway_count": 5,
        "publication_count": 111,
        "publication_id_list": "10047984;10092231;10330186;10470034;10619026;10639334;10748018;10753910;10924361;10975528;11067852;11134534;11237011;11278486;11313932;11331307;11804587;11942626;12198493;12453877;12783890;12802051;12923170;14514689;14580336;15000491;15003508;15184667;15378014;15791647;16202622;16204230;16431080;16431929;16854367;17301291;17322306;18006505;18212344;18691976;18829550;19289088;19513348;19664995;19723632;20068231;20444238;21098037;21351730;21749319;22293177;22937917;23161543;23186163;23444367;23716662;24128008;24166499;24859002;25645385;28228285;28657654;28832583;28904123;29242379;29393594;29557506;29605689;29632046;30059200;30379171;30620550;3079756;31154438;31492838;31844290;31848261;32161166;32350084;32488085;32938616;32938750;33298915;33968037;34509645;35051231;35064454;35132862;35154160;35251023;35254053;37506472;37541260;38070790;3839510;39531497;40307207;7559638;8107774;8543060;8662509;9278512;9354661;9535855;9570949;9683637;9792683;9870942;9870943;9889122;9988689",
        "class_list": "",
        "function": "FAT10 differentially stabilizes MYPT2 isoforms., [RefSeq, PubMed]; MicroRNA-4463 facilitates the development of colon cancer by suppression of the expression of PPP1R12B., [RefSeq, PubMed]; Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]., [RefSeq]; Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Revealing PPP1R12B and COL1A1 as piRNA pathway genes contributing to abdominal aortic aneurysm through integrated analysis and experimental validation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0A0MS24;A8MYF5;B7ZMN6;Q2TAI8;Q5T506;Q5VUK2;Q8N179;Q9HCB7;Q9HCB8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004857 enzyme inhibitor activity;GO:0008047 enzyme activator activity;GO:0019901 protein kinase binding;GO:0019208 phosphatase regulator activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001725 stress fiber;GO:0030018 Z disc",
        "go_biological_process": "GO:0007165 signal transduction;GO:0048812 neuron projection morphogenesis;GO:0006937 regulation of muscle contraction",
        "synthesized_glycan_count": 0,
        "hit_score": 11.4,
        "record_id": "O60237-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14168-1",
        "uniprot_id": "MPP2_HUMAN",
        "mass": 64581.0,
        "length": 576,
        "protein_name": "MAGUK p55 subfamily member 2",
        "gene_name": "MPP2",
        "organism": "Human",
        "refseq_name": "MAGUK p55 subfamily member 2 isoform 1",
        "refseq_ac": "NP_001265299",
        "gene_names_uniprotkb": "MPP2; DLG2",
        "gene_names_refseq": "DLG2; MPP2",
        "protein_names_uniprotkb": "MAGUK p55 subfamily member 2; Discs large homolog 2; Protein MPP2",
        "protein_names_refseq": "MAGUK p55 subfamily member 2 isoform 1; MAGUK p55 subfamily member 2; discs large, homolog 2; membrane palmitoylated protein 2; membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4355)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "11230166;11237011;19665017;19690332;25576301;25645385;25880248;26375851;27543614;27846572;27893789;28228285;29508533;29557506;30315122;30484775;31154438;31844290;31848261;32350084;32938616;33141586;33592498;33936100;33968037;34171305;35051231;35251023;36215666;36241641;36284347;37828081;7590743",
        "class_list": "",
        "function": "A de novo missense mutation in MPP2 confers an increased risk of Vogt-Koyanagi-Harada disease as shown by trio-based whole-exome sequencing., [RefSeq, PubMed]; MPP2 interacts with c-Src in cells to control c-Src activity and morphological function., [RefSeq, PubMed]; Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs).  MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions.  Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]., [RefSeq]; Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017)., [UniProtKB, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DGE9;B4DRJ0;B7Z3G8;E7EV80;E7EV91;E7EX01;Q53ES9;Q5CZB9;Q9BQJ2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0098919 structural constituent of postsynaptic density",
        "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0014069 postsynaptic density;GO:0043197 dendritic spine",
        "go_biological_process": "GO:0051260 protein homooligomerization;GO:0060079 excitatory postsynaptic potential;GO:0060291 long-term synaptic potentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q14168-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96AM1-1",
        "uniprot_id": "MRGRF_HUMAN",
        "mass": 38171.0,
        "length": 343,
        "protein_name": "Mas-related G protein-coupled receptor member F",
        "gene_name": "MRGPRF",
        "organism": "Human",
        "refseq_name": "mas-related G-protein coupled receptor member F",
        "refseq_ac": "NP_001091985",
        "gene_names_uniprotkb": "MRGPRF; GPR140; GPR168; MRGF; PSEC0142",
        "gene_names_refseq": "GPR140; GPR168; MRGF; MRGPRF; RTA",
        "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member F; G protein-coupled receptor 140; G protein-coupled receptor 168; Mas-related gene F protein",
        "protein_names_refseq": "G protein-coupled receptor MrgF; G-protein coupled receptor 140; G-protein coupled receptor 168; MAS-related GPR, member F; Mas-related G protein-coupled receptor F; mas-related G protein-coupled MRGF; mas-related G-protein coupled receptor member F; mas-related gene F protein; seven transmembrane helix receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:116535)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;16303743;35051231",
        "class_list": "",
        "function": "Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KV43;Q8NBK8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q96AM1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60524-1",
        "uniprot_id": "NEMF_HUMAN",
        "mass": 122954.0,
        "length": 1076,
        "protein_name": "Ribosome quality control complex subunit NEMF",
        "gene_name": "NEMF",
        "organism": "Human",
        "refseq_name": "ribosome quality control complex subunit NEMF isoform 2",
        "refseq_ac": "NP_001288661",
        "gene_names_uniprotkb": "NEMF; SDCCAG1",
        "gene_names_refseq": "IDDSAPN; NEMF; NY-CO-1; RQC2; SDCCAG1",
        "protein_names_uniprotkb": "Ribosome quality control complex subunit NEMF; Antigen NY-CO-1; Nuclear export mediator factor; Serologically defined colon cancer antigen 1",
        "protein_names_refseq": "New-York Colon 1; antigen NY-CO-1; caliban homolog; ribosome quality control complex subunit NEMF isoform 2; ribosome quality control complex subunit NEMF; serologically defined colon cancer antigen 1",
        "tax_id": 9606,
        "disease": "neuromuscular disease (Disease Ontology:DOID:440); neuropathy (Disease Ontology:DOID:870); intellectual developmental disorder with speech delay and axonal peripheral neuropathy (MONDO:MONDO:0030849)",
        "pathway": " (hsa:9147);  (R-HSA-9954709)",
        "pathway_count": 2,
        "publication_count": 88,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;16103875;17081983;17322306;18452278;18669648;19415658;19651622;19664994;19690332;20058876;20068231;21209280;21406692;23186163;23685075;24275569;24715725;25132172;25576301;25578875;25645385;25802875;26154972;26375851;26992070;27431290;27600516;27846572;27920218;28228285;28649982;28832583;28855257;28904123;29242379;29393594;29493099;29508533;29557506;29632312;29632711;29786170;30244831;30315122;30484775;31011209;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32726578;32897882;32934225;32938616;32983136;33048237;33298915;33392160;33406423;33592498;33691108;33717175;33909987;33936100;33968037;34171305;34185709;34509645;34932366;35051231;35154160;35318648;35561310;35580925;36010968;36241641;36284347;37676773;37938771;38665916;40914422;9610721",
        "class_list": "",
        "function": "Biallelic loss-of-function variants in NEMF cause central nervous system impairment and axonal polyneuropathy., [RefSeq, PubMed]; Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:25578875, PubMed:32726578, PubMed:33406423, PubMed:33909987). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:25578875, PubMed:33406423, PubMed:33909987). Within the RQC complex, NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of LTN1 to stalled 60S subunits (PubMed:25578875). Following binding to stalled 60S ribosomal subunits, NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (PubMed:33406423, PubMed:33909987). Mainly recruits alanine-charged tRNAs, but can also other amino acid-charged tRNAs (PubMed:33406423, PubMed:33909987). CAT tailing is required to promote ubiquitination of stalled nascent chains by different E3 ubiquitin-protein ligases (PubMed:33909987). In the canonical RQC pathway (RQC-L), CAT tailing facilitates LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (By similarity). In the alternative RQC pathway (RQC-C) CAT tailing creates an C-degron mainly composed of alanine that is recognized by the CRL2(KLHDC10) and RCHY1/PIRH2 E3 ligases, leading to ubiquitination and degradation of stalled nascent chains (PubMed:33909987). NEMF may also indirectly play a role in nuclear export (PubMed:16103875)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Results show that Listerin specificity for nascent chain-60S complexes depends on nuclear export mediator factor., [RefSeq, PubMed]; This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 17,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0JLQ3;B3KSK1;B4DDL3;B4DHA9;B4E3F3;Q32Q66;Q8WW70;Q9NWG1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000049 tRNA binding;GO:0043023 ribosomal large subunit binding;GO:1904678 alpha-aminoacyl-tRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:1990112 RQC complex;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0051168 nuclear export;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process;GO:0065003 protein-containing complex assembly;GO:0140708 CAT tailing",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "O60524-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P41218-1",
        "uniprot_id": "MNDA_HUMAN",
        "mass": 45836.0,
        "length": 407,
        "protein_name": "Myeloid cell nuclear differentiation antigen",
        "gene_name": "MNDA",
        "organism": "Human",
        "refseq_name": "myeloid cell nuclear differentiation antigen",
        "refseq_ac": "NP_002423",
        "gene_names_uniprotkb": "MNDA",
        "gene_names_refseq": "MNDA; PYHIN3",
        "protein_names_uniprotkb": "Myeloid cell nuclear differentiation antigen",
        "protein_names_refseq": "epididymis secretory sperm binding protein; myeloid cell nuclear differentiation antigen",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4332);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 57,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;1377701;1644857;18991276;23650620;24714562;24715725;26154972;26375851;27452731;27846572;27862975;27920218;28063628;28218747;28514659;28832583;28904123;29493099;29508533;29557506;29632046;29632711;29786170;30346478;30429286;31154438;31611695;31844290;31848261;31998317;32157095;32265295;32387766;32502341;32682001;32938750;32983136;33043033;33091337;33141586;33298915;33392160;34171305;34932366;35051231;35580925;36284347;37938771;38680493;38904028;7512843;7806273;8175894;8692836;9712147",
        "class_list": "",
        "function": "IRTA1 and MNDA are useful markers in the differential diagnosis of marginal zone lymphomas (MZLs)., [RefSeq, PubMed]; MNDA controls the expression of MCL-1 and BCL-2 in chronic lymphocytic leukemia cells., [RefSeq, PubMed]; MNDA, a PYHIN factor involved in transcriptional regulation and apoptosis control in leukocytes. Review article Publication Status: Online-Only, [RefSeq, PubMed]; May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1., [UniProtKB]; Myeloid cell-expressed MNDA enhances M2 polarization to facilitate the metastasis of hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003690 double-stranded DNA binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043065 positive regulation of apoptotic process;GO:0006968 cellular defense response;GO:0006974 DNA damage response;GO:0050853 B cell receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "P41218-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96FV9-1",
        "uniprot_id": "THOC1_HUMAN",
        "mass": 75666.0,
        "length": 657,
        "protein_name": "THO complex subunit 1",
        "gene_name": "THOC1",
        "organism": "Human",
        "refseq_name": "THO complex subunit 1",
        "refseq_ac": "NP_005122",
        "gene_names_uniprotkb": "THOC1; HPR1",
        "gene_names_refseq": "DFNA86; HPR1; P84N5; P84; THOC1",
        "protein_names_uniprotkb": "THO complex subunit 1; Nuclear matrix protein p84; hTREX84; p84N5",
        "protein_names_refseq": "THO complex 1; THO complex subunit 1; hTREX84; nuclear matrix protein p84; tho1",
        "tax_id": 9606,
        "disease": "autosomal dominant nonsyndromic deafness 86 (Disease Ontology:DOID:0070610)",
        "pathway": " (hsa:9984);  (R-HSA-159236);  (R-HSA-72187)",
        "pathway_count": 3,
        "publication_count": 104,
        "publication_id_list": "10.1101/2023.09.13.557529;10228171;10323864;10489353;10512864;10668806;10840029;11050087;11073998;11237011;11256625;11259411;11259602;11579093;11739738;11756420;11979277;12093754;12096345;12871933;15302935;15358532;15833825;15870275;15998806;16314397;17000901;17190602;17984224;18220336;18364396;18411249;18423201;18452278;18669648;18957205;18974867;19608861;19651622;19836239;20068231;20129943;20573985;20844015;21947206;22144908;22207203;22893130;22928037;23186163;23222130;23299939;23301498;23460917;23481700;23826332;24244187;25114211;25218447;25576301;25662211;25755297;25772364;25836925;26375851;26992070;27600516;27920218;28218747;28228285;28832583;28834231;28904123;29242379;29508533;29557506;29632046;29769354;29786170;30315122;30379171;31844290;32157095;32357974;32488085;32502341;32669125;32776944;32938616;33191911;33592498;33968037;34019948;35051231;35561310;35580925;36215666;37020021;37217939;39302247;40914422;7525595;9618489;9660949",
        "class_list": "",
        "function": "(Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production., [UniProtKB, PubMed]; Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B/UAP56 (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Regulates transcriptional elongation of a subset of genes (PubMed:22144908). Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Knockdown of THOC1 reduces the proliferation of hepatocellular carcinoma and increases the sensitivity to cisplatin. Erratum:[J Exp Clin Cancer Res. 2024 Oct 14;43(1):285. doi: 10.1186/s13046-024-03208-3. PMID: 39396979] Publication Status: Online-Only, [RefSeq, PubMed]; Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1., [UniProtKB]; THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBP6;Q15219;Q64I72;Q64I73",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0000347 THO complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0007165 signal transduction;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 10.9,
        "record_id": "Q96FV9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6SZW1-1",
        "uniprot_id": "SARM1_HUMAN",
        "mass": 79388.0,
        "length": 724,
        "protein_name": "NAD(+) hydrolase SARM1",
        "gene_name": "SARM1",
        "organism": "Human",
        "refseq_name": "NAD(+) hydrolase SARM1 precursor",
        "refseq_ac": "NP_055892",
        "gene_names_uniprotkb": "SARM1; KIAA0524; SAMD2; SARM",
        "gene_names_refseq": "HsTIR; MyD88-5; SAMD2; SARM1; SARM; hSARM1",
        "protein_names_uniprotkb": "NAD(+) hydrolase SARM1; 3.2.2.-; 3.2.2.6; HsTIR; MyD88-5; NADP(+) hydrolase SARM1; NADase SARM1; SAM domain-containing protein 2; Sterile alpha and Armadillo repeat protein; Sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; Tir-1 homolog; hSARM1",
        "protein_names_refseq": "NAD(+) hydrolase SARM1 precursor; NAD(+) hydrolase SARM1; NADP(+) hydrolase SARM1; NADase SARM1; SAM domain-containing protein 2; sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif-containing protein 1; sterile alpha motif domain-containing protein 2; tir-1 homolog",
        "tax_id": 9606,
        "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)",
        "pathway": " (hsa:23098)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11386760;15123841;15893701;16964262;16985498;17724133;18089857;20306472;22145856;24715725;25908823;26992070;27671644;28228285;28334607;28832583;28834231;29242379;29393594;29395922;29557506;30315122;30333228;30379171;31128467;31278906;31439792;31439793;31844290;32049506;32350084;32502341;32755591;32828421;32938616;32983136;33053563;33717175;33912179;34357683;34561969;36010968;37742918;38635746;38692735;38852438;41138726",
        "class_list": "",
        "function": "A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels., [RefSeq, PubMed]; Augustus Waller's foresight realized: SARM1 in peripheral neuropathies. Review article, [RefSeq, PubMed]; Candidate gene in the onset of hereditary infectious/inflammatory diseases., [RefSeq, PubMed]; Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons. Publication Status: Online-Only, [RefSeq, PubMed]; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439792, PubMed:31439793, PubMed:32049506, PubMed:32828421, PubMed:33053563). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262). Acts as a non-self dsDNA sensor in a sequence-independent manner to elicit NAD(+) degradation and thus to promote programmed cell death (PubMed:41138726)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; TIR adaptor SARM is a negative regulator of Toll-like receptor signaling., [RefSeq, PubMed]; The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 66,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60277;Q7LGG3;Q9NXY5",
        "ec_number_list": "3.2.2.6;2.4.99.20;3.2.2.-",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding;GO:0035591 signaling adaptor activity;GO:0003953 NAD+ nucleosidase activity;GO:0050135 NADP+ nucleosidase activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol",
        "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0070585 protein localization to mitochondrion;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q6SZW1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P08253-1",
        "uniprot_id": "MMP2_HUMAN",
        "mass": 73882.0,
        "length": 660,
        "protein_name": "72 kDa type IV collagenase",
        "gene_name": "MMP2",
        "organism": "Human",
        "refseq_name": "72 kDa type IV collagenase isoform 2",
        "refseq_ac": "NP_001121363",
        "gene_names_uniprotkb": "MMP2; CLG4A",
        "gene_names_refseq": "CLG4A; CLG4; MMP-2; MMP-II; MMP2; MONA; TBE-1",
        "protein_names_uniprotkb": "72 kDa type IV collagenase; 3.4.24.24; 72 kDa gelatinase; Gelatinase A; MMP-2; Matrix metalloproteinase-2; TBE-1",
        "protein_names_refseq": "72 kDa type IV collagenase isoform 2; collagenase type IV-A; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase-2; matrix metalloproteinase-II; neutrophil gelatinase",
        "tax_id": 9606,
        "disease": "pterygium (Disease Ontology:DOID:0002116); cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); atrial fibrillation (Disease Ontology:DOID:0060224); aortic valve disease 2 (Disease Ontology:DOID:0080334); COVID-19 (Disease Ontology:DOID:0080600); Sweet syndrome (Disease Ontology:DOID:0080746); immunoglobulin light chain amyloidosis (Disease Ontology:DOID:0080933); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); traumatic brain injury (Disease Ontology:DOID:0081292); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); keratoconus (Disease Ontology:DOID:10126); prostate cancer (Disease Ontology:DOID:10283); adrenoleukodystrophy (Disease Ontology:DOID:10588); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); intracranial aneurysm (Disease Ontology:DOID:10941); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); polycystic ovary syndrome (Disease Ontology:DOID:11612); myopia (Disease Ontology:DOID:11830); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); primary biliary cholangitis (Disease Ontology:DOID:12236); leiomyoma (Disease Ontology:DOID:127); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); cholestasis (Disease Ontology:DOID:13580); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Marfan syndrome (Disease Ontology:DOID:14323); alcohol use disorder (Disease Ontology:DOID:1574); retinal vein occlusion (Disease Ontology:DOID:1727); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); arteriosclerosis (Disease Ontology:DOID:2349); hemangioma (Disease Ontology:DOID:255); transitional cell carcinoma (Disease Ontology:DOID:2671); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); endometriosis (Disease Ontology:DOID:289); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); carotid artery disease (Disease Ontology:DOID:3407); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); heart valve disease (Disease Ontology:DOID:4079); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); stomach carcinoma (Disease Ontology:DOID:5517); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); conjunctivitis (Disease Ontology:DOID:6195); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); pyoderma gangrenosum (Disease Ontology:DOID:8553); cholesteatoma (Disease Ontology:DOID:869); vascular dementia (Disease Ontology:DOID:8725); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); cutaneous leishmaniasis (Disease Ontology:DOID:9111); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); pulmonary emphysema (Disease Ontology:DOID:9675); multicentric osteolysis, nodulosis, and arthropathy (MONDO:MONDO:0009809)",
        "pathway": " (hsa:4313);  (R-HSA-1442490);  (R-HSA-1474228);  (R-HSA-1592389);  (R-HSA-381426);  (R-HSA-3928665);  (R-HSA-6785807);  (R-HSA-9009391)",
        "pathway_count": 8,
        "publication_count": 421,
        "publication_id_list": "10023775;10026136;10049780;10077652;10218588;10219247;10229672;10319328;10356396;10369418;10386589;10427092;10510379;10512690;10545322;10551873;10559137;10586089;10614670;10681634;10706100;10749889;10806474;10809722;10810289;10867011;10898936;10912521;10951195;10986281;10990447;11013208;11029009;11029402;11029403;11043579;11044445;11058569;11084045;11104795;11119712;11120780;11158056;11179305;11185956;11237011;11250653;11264294;11278437;11278729;11316783;11320090;11356008;11369763;11375993;11404481;11431697;11448999;11463377;11522292;11577169;11606061;11689445;11710594;11739083;11751371;11751392;11773442;11773443;11788658;11825873;11830519;11872628;11927537;11928808;11960372;11981029;12032297;12048194;12147339;12223527;12241545;12242343;12379487;12388769;12421825;12431978;12466191;12511868;12579531;12588983;12600988;12682286;12714657;12727852;12808053;12810533;12832402;12843408;12879005;12881510;12904166;12973357;1311314;1370451;1371271;1378832;1383255;1390635;14634100;14712222;14764897;14766804;1480033;1480041;14973287;15005656;15033483;15044318;15090535;15116091;15126567;15231873;15234972;15257288;15261459;15308688;15314172;15351694;15467163;15469690;15485880;15496458;15525596;15569929;15584925;15591058;15642270;15657067;15691365;15705661;15805299;15848800;15869882;15950618;15950906;15956360;15958533;16007214;16048438;16107692;16133547;16205632;16236134;16239258;16274718;16397018;16451196;1649600;16510571;16511561;16540365;16542393;1655733;16606674;16631740;16636149;16645038;16825197;16825321;16835357;16959974;1698775;17037979;1704217;17047378;1707285;17088321;17249697;17312271;17332331;17354228;17424910;17427945;17428795;17435175;17458857;17525128;17535799;17572495;17608959;1783204;17916740;17921256;17985932;18206197;18243101;18353781;18434311;18447642;1851724;18622425;18644974;18657504;18658137;18713744;18971601;19010778;19124156;19138696;19185846;19397496;19493954;19571574;19657146;19714641;19879889;2005102;20142769;20166139;20439495;20493732;20496116;20650261;20861220;21030783;21081667;21102457;21252155;21297635;21441952;2158484;21593211;2159879;2162831;21670566;21680538;21689689;2169257;2169335;21730069;2176865;21784848;21813640;21851428;21864727;21935455;21937440;21994466;22028449;22031296;22046235;22159414;22205702;22241472;22266855;22382088;22383755;22446104;22509276;2253219;2269296;22693070;22851691;22905912;23035980;23086340;23124025;23172665;23455323;23555662;2383557;23845380;23967200;24039841;24097101;24530924;24743777;2476804;2479552;25234944;25261607;2537292;2546891;2548603;2551898;25576301;2557753;25587652;26091039;26992070;27288742;27726376;27846572;28218747;2834383;2845110;28539435;29557506;29738483;29786170;29789417;3038863;30429286;30459171;3058116;31844290;31848261;32157095;32161166;32176626;3223920;32387766;32983136;33043033;33592498;34185709;35051231;35251023;35580925;36010968;36284347;37938771;39011948;39191502;4216367;6258630;6263256;6270089;6694361;7075587;7510216;7512451;7519608;7523391;7525263;7525634;7525824;7526779;7527330;7529288;7538844;7543116;7547873;7583664;7588299;7669817;7683646;7689487;7746327;7750475;7780967;7795521;7796300;7826345;7890645;7890717;7896811;7898939;7907877;7981201;8015608;8085155;8194591;8226919;8269931;8314771;8463259;8530478;8549817;8576151;8602263;8621565;8621622;8626565;8645182;8646777;8663118;8663255;8668165;8781553;8782602;8797861;8804434;8816495;8817670;8876252;8894645;8920930;8964575;8999957;9013879;9054449;9065415;9092507;9115292;9119036;9148753;9173876;9261109;9346290;9395517;9422744;9461298;9476898;9497324;9565625;9578462;9616126;9632662;9651359;9651395;9709957;9723655;9733769;9736340;9786878;9822675;9852107;9874564;9922210",
        "class_list": "",
        "function": "Co-expression of CD44v6 and MMP2 predicts lung metastasis and unfavorable prognosis in osteosarcoma., [RefSeq, PubMed]; Impacts of Matrix Metalloproteinase-2 Promoter Genotypes on Breast Cancer Risk., [RefSeq, PubMed]; Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways., [UniProtKB]; PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels., [UniProtKB]; The roles of MMP-2 in cardiac injury and repair. [Review] Review article, [RefSeq, PubMed]; This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]., [RefSeq]; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14., [UniProtKB]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 3939,
        "biomarker_type": "prognostic",
        "glycan_count": 2,
        "disease_count": 84,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6U1;B4DWH3;E9PE45;Q9UCJ8",
        "ec_number_list": "3.4.24.-;3.4.24.7;3.4.21.4;2.7.10.1;3.4.21.37;3.4.24.24;3.4.24.17;3.4.24.23;3.4.24.22;3.4.24.19;3.4.24.35;3.4.24.34;3.4.24.65;3.4.24.80",
        "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0007162 negative regulation of cell adhesion;GO:0007507 heart development;GO:0016477 cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 42.5,
        "record_id": "P08253-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N565-1",
        "uniprot_id": "MREG_HUMAN",
        "mass": 24927.0,
        "length": 214,
        "protein_name": "Melanoregulin",
        "gene_name": "MREG",
        "organism": "Human",
        "refseq_name": "melanoregulin isoform 2",
        "refseq_ac": "NP_060470",
        "gene_names_uniprotkb": "MREG; DSU; HDCGA21P",
        "gene_names_refseq": "DSU; MREG; WDT2",
        "protein_names_uniprotkb": "Melanoregulin; Dilute suppressor protein homolog",
        "protein_names_refseq": "dilute suppressor protein homolog; melanoregulin isoform 2; whn-dependent transcript 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55686)",
        "pathway_count": 1,
        "publication_count": 30,
        "publication_id_list": "11237011;17260955;19240024;19664994;20463177;21406692;23481700;25301234;25502872;28467828;28514659;28698135;28832583;28904123;29242379;29557506;30626607;31844290;32157095;32350084;32502341;32983136;33043033;33298915;33717175;33936100;33968037;34932366;35154160;35494241",
        "class_list": "",
        "function": "MREG-dependent processing links both autophagic and phagocytic processes in LC3-associated phagocytosis. MREG participates in coordinating the association of phagosomes with LC3 for content degradation with the MREG loss leading to phagosome accumulation., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity)., [UniProtKB, PubMed, UniProtKB]; Taken together, MREG regulates thyroid cancer cell invasion and proliferation through PI3K/Akt-mTOR signaling pathway. MREG may serve as a promising therapeutic strategy for thyroid cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53R89;Q53TC1;Q5XKB6;Q9NWC9;Q9P1S1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0035091 phosphatidylinositol binding",
        "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031902 late endosome membrane;GO:0042470 melanosome",
        "go_biological_process": "GO:0090382 phagosome maturation;GO:0032402 melanosome transport;GO:0032400 melanosome localization;GO:0030318 melanocyte differentiation;GO:0072385 minus-end-directed organelle transport along microtubule",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q8N565-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NTX5-1",
        "uniprot_id": "ECHD1_HUMAN",
        "mass": 33698.0,
        "length": 307,
        "protein_name": "Ethylmalonyl-CoA decarboxylase",
        "gene_name": "ECHDC1",
        "organism": "Human",
        "refseq_name": "ethylmalonyl-CoA decarboxylase isoform 1",
        "refseq_ac": "NP_001002030",
        "gene_names_uniprotkb": "ECHDC1",
        "gene_names_refseq": "ECHDC1; HEL-S-76; MMCD; dJ351K20.2",
        "protein_names_uniprotkb": "Ethylmalonyl-CoA decarboxylase; 4.1.1.94; Enoyl-CoA hydratase domain-containing protein 1; MMCD; Methylmalonyl-CoA decarboxylase",
        "protein_names_refseq": "enoyl CoA hydratase domain containing 1; enoyl Coenzyme A hydratase domain containing 1; enoyl-CoA hydratase domain-containing protein 1; epididymis secretory protein Li 76; ethylmalonyl-CoA decarboxylase isoform 1; methylmalonyl-CoA decarboxylase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55862)",
        "pathway_count": 1,
        "publication_count": 75,
        "publication_id_list": "11237011;18326623;19517271;19789366;20407466;22016388;22424782;23481700;24715725;25576301;26154972;26992070;27600516;27846572;27920218;28228285;28510447;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632711;29786170;30315122;30379171;30524438;30779550;30833945;31092671;31154438;31530632;31844290;31848261;31937595;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33691108;33717175;33750001;33912179;33936100;33968037;33973257;33981976;34087483;34171305;34211107;34229054;34405274;34509645;34932366;35051231;35318648;35580925;36010968;36215666;36241641;36284347;40596516;40914422",
        "class_list": "",
        "function": "Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer. Also has methylmalonyl-CoA decarboxylase activity at lower level., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor., [RefSeq, PubMed]; Mutations in the coding regions of the RNF146 and ECHDC1 genes do not contribute to the burden of inherited predisposition of breast cancer in Ashkenazi high risk women. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]; Variants in the ethylmalonyl-CoA decarboxylase (ECHDC1) gene: a novel player in ethylmalonic aciduria?, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NFJ5;B7Z8S0;E9PEN7;E9PR31;F8W851;Q5TEF6;Q5TEF7;Q5TEG0;Q5TEG4;Q9NZ30;V9HW18",
        "ec_number_list": "4.1.1.94",
        "go_molecular_function": "GO:0004492 methyl/ethyl malonyl-CoA decarboxylase activity;GO:0016831 carboxy-lyase activity;GO:0003824 catalytic activity;GO:0016829 lyase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0006635 fatty acid beta-oxidation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q9NTX5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O43795-1",
        "uniprot_id": "MYO1B_HUMAN",
        "mass": 131985.0,
        "length": 1136,
        "protein_name": "Unconventional myosin-Ib",
        "gene_name": "MYO1B",
        "organism": "Human",
        "refseq_name": "unconventional myosin-Ib isoform 1",
        "refseq_ac": "NP_001123630",
        "gene_names_uniprotkb": "MYO1B",
        "gene_names_refseq": "MMI-alpha; MMIa; MYH-1c; MYO1B; myr1",
        "protein_names_uniprotkb": "Unconventional myosin-Ib; MMI-alpha; MMIa; MYH-1c; Myosin I alpha",
        "protein_names_refseq": "MYO1B variant protein; myosin-I alpha; unconventional myosin-Ib isoform 1; unconventional myosin-Ib",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4430)",
        "pathway_count": 1,
        "publication_count": 60,
        "publication_id_list": "11237011;12486594;16959974;20112406;24275569;25114211;25218447;25576301;25645385;25755297;26992070;27397612;27600516;27846572;27862975;28832583;29242379;29331515;29393594;29493099;29557506;29786170;29789417;30397120;30429286;30524438;31844290;32157095;32488085;32502341;32938616;32983136;33123756;33141586;33537174;33592498;33968037;33981976;34087483;34171305;34185709;34229054;34725712;34932366;35051231;35083852;35318648;35580925;35861939;36010968;36215666;36241641;36284347;36347835;36654782;37014156;37481637;37938771;38253038;38665916",
        "class_list": "",
        "function": "At apical surfaces of supporting cells that surround hair cells in auditory epithelia of postnatal rats. In vestibular epithelia, present in ring within apical pole of hair cell. Expression was prominent only immediately after birth., [RefSeq, PubMed]; CCND1-associated ceRNA network reveal the critical pathway of TPRG1-AS1-hsa-miR-363-3p-MYO1B as a prognostic marker for head and neck squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; MYO1B as a prognostic biomarker and a therapeutic target in Arecoline-associated oral carcinoma., [RefSeq, PubMed]; Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport., [UniProtKB, UniProtKB, UniProtKB]; Myo1b Promotes Premature Endothelial Senescence and Dysfunction via Suppressing Autophagy: Implications for Vascular Aging. Publication Status: Online-Only, [RefSeq, PubMed]; Myo1b promotes tumor progression and angiogenesis by inhibiting autophagic degradation of HIF-1alpha in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Targeting MYO1B impairs tumorigenesis via inhibiting the SNAI2/cyclin D1 signaling in esophageal squamous cell carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43794;Q7Z6L5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0051015 actin filament binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005903 brush border",
        "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0051017 actin filament bundle assembly;GO:0030048 actin filament-based movement;GO:0006892 post-Golgi vesicle-mediated transport",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "O43795-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96DM3-1",
        "uniprot_id": "RMC1_HUMAN",
        "mass": 74975.0,
        "length": 657,
        "protein_name": "Regulator of MON1-CCZ1 complex",
        "gene_name": "RMC1",
        "organism": "Human",
        "refseq_name": "regulator of MON1-CCZ1 complex isoform 3",
        "refseq_ac": "NP_001305636",
        "gene_names_uniprotkb": "RMC1; C18orf8; MIC1; WDR98",
        "gene_names_refseq": "C18orf8; HsT2591; MIC1; Mic-1; RMC1; WDR98",
        "protein_names_uniprotkb": "Regulator of MON1-CCZ1 complex; Colon cancer-associated protein Mic1; Mic-1; WD repeat-containing protein 98",
        "protein_names_refseq": "WD repeat domain 98; WD repeat-containing protein 98; colon cancer-associated protein Mic1; macrophage inhibitory cytokine 1; regulator of MON1-CCZ1 complex isoform 3; regulator of MON1-CCZ1 complex; uncharacterized protein C18orf8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29919)",
        "pathway_count": 1,
        "publication_count": 73,
        "publication_id_list": "11237011;17081983;17547437;17897319;23481700;24366607;24397554;25576301;25645385;25880248;25892735;26154972;26375851;26811146;26992070;27846572;27862975;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29038162;29242379;29393594;29437277;29493099;29557506;29632711;29769354;29786170;30315122;30410026;30779550;30833945;31154438;31530632;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33298915;33392160;33592498;33633747;33691108;33717175;33912179;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34932366;35051231;35580925;36010968;36241641;36284347;37938771",
        "class_list": "",
        "function": "Authors identified C18orf8/RMC1 as a new subunit of the CCZ1-MON1 RAB7 guanine exchange factor (GEF) that positively regulates RAB7 recruitment to LE/autophagosomes. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a colon cancer associated protein. [provided by RefSeq, Jan 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BU17;Q9Y5M0",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0005770 late endosome;GO:0035658 Mon1-Ccz1 complex",
        "go_biological_process": "GO:0010506 regulation of autophagy;GO:0006914 autophagy",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "Q96DM3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P49821-1",
        "uniprot_id": "NDUV1_HUMAN",
        "mass": 50817.0,
        "length": 464,
        "protein_name": "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial",
        "gene_name": "NDUFV1",
        "organism": "Human",
        "refseq_name": "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform 2 precursor",
        "refseq_ac": "NP_001159574",
        "gene_names_uniprotkb": "NDUFV1; UQOR1",
        "gene_names_refseq": "CI-51K; CI51KD; MC1DN4; NDUFV1; UQOR1",
        "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; 7.1.1.2; CI-51kD; Complex I-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; NDUFV1",
        "protein_names_refseq": "NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform 2 precursor; NADH-ubiquinone oxidoreductase 51 kDa subunit; complex I 51 kda subunit; complex I 51kDa subunit; complex I, mitochondrial respiratory chain; mitochondrial NADH dehydrogenase ubiquinone flavoprotein 1; mitochondrial NADH:ubiquinone oxidoreductase 51 kda subunit",
        "tax_id": 9606,
        "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 4 (Disease Ontology:DOID:0112082); mitochondrial metabolism disease (Disease Ontology:DOID:700)",
        "pathway": " (hsa:4723);  (R-HSA-611105);  (R-HSA-6799198);  (R-HSA-9837999)",
        "pathway_count": 4,
        "publication_count": 115,
        "publication_id_list": "10080174;10327278;10931946;11220739;11237011;11349233;11695836;11923310;12198491;12231006;12611891;12837546;1327877;14623864;14741580;1478657;15250827;15522782;15870080;16115876;16230336;17033964;17101804;17297443;17579211;17936786;186667;19752196;19841671;20068231;20406883;20552642;20858599;21924235;22262461;22710082;23150584;23201127;23270816;23481700;23553477;23564345;23747254;23931759;239860;24191001;24315374;24520911;24715725;25564869;25678554;25892735;26504172;26923599;27452731;27496948;27499296;27626371;27642048;28063628;28228285;28377575;28396416;28510447;28844695;29242379;29301859;29393594;29557506;29632046;29632711;29769354;29932645;30120231;30315122;31327635;31536960;31611695;31666358;31695197;31844290;31866046;32157095;32265295;32320651;32502341;32938616;33141586;33257573;33298915;33592498;33717175;33879611;33882309;33912179;33968037;34704252;34725712;34943861;35051231;35115484;35333655;35482246;35614220;35870450;36629048;37938771;38199007;40914422;4288886;7623837;8288251;9571201;9878551;9892733",
        "class_list": "",
        "function": "Compound heterozygous mutations of NDUFV1 identified in a child with mitochondrial complex I deficiency., [RefSeq, PubMed]; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60924;O60940;Q16104;Q6IBR3;Q96BF8;Q96HS7",
        "ec_number_list": "7.1.1.2;2.1.2.1;3.4.21.53;3.6.4.10;2.1.1.-;1.-.-.-;2.1.1.320;1.1.98.-;1.3.8.7;1.3.8.8",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051287 NAD binding;GO:0016491 oxidoreductase activity;GO:0008137 NADH dehydrogenase (ubiquinone) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I",
        "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0042775 mitochondrial ATP synthesis coupled electron transport;GO:0009060 aerobic respiration",
        "synthesized_glycan_count": 0,
        "hit_score": 11.8,
        "record_id": "P49821-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P225-1",
        "uniprot_id": "DYH2_HUMAN",
        "mass": 507698.0,
        "length": 4427,
        "protein_name": "Dynein axonemal heavy chain 2",
        "gene_name": "DNAH2",
        "organism": "Human",
        "refseq_name": "dynein axonemal heavy chain 2 isoform 2",
        "refseq_ac": "NP_001290199",
        "gene_names_uniprotkb": "DNAH2; DNAHC2; DNHD3; KIAA1503",
        "gene_names_refseq": "DNAH2; DNAHC2; DNHD3; SPGF45",
        "protein_names_uniprotkb": "Dynein axonemal heavy chain 2; Axonemal beta dynein heavy chain 2; Ciliary dynein heavy chain 2; Dynein heavy chain domain-containing protein 3",
        "protein_names_refseq": "axonemal beta dynein heavy chain 2; ciliary dynein heavy chain 2; dynein axonemal heavy chain 2 isoform 2; dynein heavy chain 2, axonemal; dynein heavy chain domain-containing protein 3; dynein, axonemal, heavy polypeptide 2",
        "tax_id": 9606,
        "disease": "spermatogenic failure 45 (Disease Ontology:DOID:0112163)",
        "pathway": " (hsa:146754)",
        "pathway_count": 1,
        "publication_count": 31,
        "publication_id_list": "11237011;17924679;19415658;20835228;23481700;24715725;28228285;28832583;29393594;29557506;30811583;31178125;31844290;32350084;32387766;32488085;32938616;32983136;33771466;33912179;33968037;34087483;34171305;34509645;35051231;35580925;36010968;36284347;37217939;38253038;9256245",
        "class_list": "",
        "function": "As part of the axonemal inner dynein arm complex plays a central role in ciliary beat (PubMed:30811583). Expressed in sperm flagellum, it is required for sperm motility (PubMed:30811583). Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending (PubMed:30811583)., [UniProtKB, PubMed]; Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).[supplied by OMIM, Mar 2008]., [RefSeq]; Novel bi-allelic variants in DNAH2 cause severe asthenoteratozoospermia with multiple morphological abnormalities of the flagella., [RefSeq, PubMed]; The DNAH2 mutation can cause severe sperm flagella defects that damage sperm motility., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 120,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K992;B5MDX5;O15434;Q6PIH3;Q6ZR42",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0003777 microtubule motor activity;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding",
        "go_cellular_component": "GO:0097229 sperm end piece;GO:0005874 microtubule;GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme",
        "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0036159 inner dynein arm assembly;GO:0060285 cilium-dependent cell motility;GO:0007018 microtubule-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q9P225-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96JB8-1",
        "uniprot_id": "MPP4_HUMAN",
        "mass": 72779.0,
        "length": 637,
        "protein_name": "MAGUK p55 subfamily member 4",
        "gene_name": "MPP4",
        "organism": "Human",
        "refseq_name": "MAGUK p55 subfamily member 4 isoform 1",
        "refseq_ac": "NP_149055",
        "gene_names_uniprotkb": "MPP4; ALS2CR5; DLG6",
        "gene_names_refseq": "ALS2CR5; DLG6; MPP4",
        "protein_names_uniprotkb": "MAGUK p55 subfamily member 4; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein; Discs large homolog 6",
        "protein_names_refseq": "MAGUK p55 subfamily member 4 isoform 1; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein; discs large homolog 6; membrane palmitoylated protein 4; membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:58538)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;11414766;11586298;12384283;15558731;15914641;19807924;23301498;24715725;28228285;28276657;32157095;33968037;36477533",
        "class_list": "",
        "function": "Bipolar disorder participants with a history of Suicidal behavior showed less overall methylation in the 5' untranslated region of Membrane palmitoylated protein 4 ., [RefSeq, PubMed]; MPP4 gene is highly expressed in retina, but no mutations were identified in a panel of 300 unrelated patients with retinitis pigmentosa., [RefSeq, PubMed]; May play a role in retinal photoreceptors development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organization of specialized intercellular junctions. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9IZK4;Q53TT3;Q6ZNH6;Q96Q43;Q96Q44",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0032991 protein-containing complex;GO:0016020 membrane",
        "go_biological_process": "GO:0035418 protein localization to synapse;GO:0008104 intracellular protein localization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q96JB8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96T58-1",
        "uniprot_id": "MINT_HUMAN",
        "mass": 402248.0,
        "length": 3664,
        "protein_name": "Msx2-interacting protein",
        "gene_name": "SPEN",
        "organism": "Human",
        "refseq_name": "msx2-interacting protein",
        "refseq_ac": "NP_055816",
        "gene_names_uniprotkb": "SPEN; KIAA0929; MINT; SHARP",
        "gene_names_refseq": "HIAA0929; MINT; RATARS; RBM15C; SHARP; SPEN",
        "protein_names_uniprotkb": "Msx2-interacting protein; SMART/HDAC1-associated repressor protein; SPEN homolog",
        "protein_names_refseq": "Msx2 interacting nuclear target (MINT) homolog; SMART/HDAC1-associated repressor protein; msx2-interacting protein; nuclear receptor transcription cofactor; spen homolog, transcriptional regulator",
        "tax_id": 9606,
        "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); nasopharynx carcinoma (Disease Ontology:DOID:9261); Radio-Tartaglia syndrome (MONDO:MONDO:0859143)",
        "pathway": " (hsa:23013);  (R-HSA-9013422)",
        "pathway_count": 2,
        "publication_count": 157,
        "publication_id_list": "11237011;11331609;11867749;12374742;12897056;15824732;16129689;16959974;17081983;17287340;17322306;17525332;18212344;18452278;18669648;18835386;18991276;19413330;19562805;19651622;19664995;19690332;20068230;20068231;21158410;21406692;23186163;23301498;23481700;24129315;24275569;24608665;24714562;24715725;25418920;25505266;25576301;25645385;25892735;26154972;26375851;26811146;26992070;27114449;27314390;27503676;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28314751;28446606;28514659;28649982;28657654;28832583;28834231;28855257;28904123;29237092;29242379;29331515;29351928;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30059200;30192525;30315122;30379171;30410026;30429286;30484775;30524438;30620550;30833945;30896450;31092671;31154438;31217245;31431478;31492838;31530632;31844290;31848261;31871319;31937595;31998317;32119511;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32574038;32641685;32897882;32938616;32938750;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33596411;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34185709;34357683;34509645;34561969;34725712;34846842;34932366;35051231;35132862;35254053;35289036;35318648;35513511;35580925;35705054;36010968;36215666;36241641;36284347;37340703;37541260;37938771;38164599;38665916;38838015;39302247;39531497;39534244;40307207;40596516;41350704",
        "class_list": "",
        "function": "Dissection of protein and RNA regions required for SPEN binding to XIST A-repeat RNA. Publication Status: Online-Only, [RefSeq, PubMed]; May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA., [UniProtKB, PubMed, UniProtKB, PubMed]; SHARP is a novel component of the HDAC corepressor complex, recruited by RBP-Jkappa to repress transcription of target genes in the absence of activated Notch., [RefSeq, PubMed]; SPEN haploinsufficiency causes a neurodevelopmental disorder overlapping proximal 1p36 deletion syndrome with an episignature of X chromosomes in females., [RefSeq, PubMed]; SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 5,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 83,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 83,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 83,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 89,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 259,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 88,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9H9A8;Q9NWH5;Q9UQ01;Q9Y556",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0017053 transcription repressor complex",
        "go_biological_process": "GO:0060816 random inactivation of X chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 24.3,
        "record_id": "Q96T58-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NVP4-1",
        "uniprot_id": "DZAN1_HUMAN",
        "mass": 82192.0,
        "length": 752,
        "protein_name": "Double zinc ribbon and ankyrin repeat-containing protein 1",
        "gene_name": "DZANK1",
        "organism": "Human",
        "refseq_name": "double zinc ribbon and ankyrin repeat-containing protein 1 isoform 3",
        "refseq_ac": "NP_001092877",
        "gene_names_uniprotkb": "DZANK1; C20orf12; C20orf84",
        "gene_names_refseq": "ANKRD64; C20orf12; C20orf84; DZANK1",
        "protein_names_uniprotkb": "Double zinc ribbon and ankyrin repeat-containing protein 1",
        "protein_names_refseq": "ankyrin repeat domain 64; ankyrin repeat-containing protein C20orf12; double zinc ribbon and ankyrin repeat-containing protein 1 isoform 3; double zinc ribbon and ankyrin repeat-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55184)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "11237011;18669648;20068231;26485514;28467828;28904123;30379171;31844290;32265295;32357974;32387766;32938616;33298915;33968037;34561969;35051231;36010968",
        "class_list": "",
        "function": "Involved in vesicle transport in photoreceptor cells., [UniProtKB, UniProtKB]; This gene contains two ankyrin repeat-encoding regions. Ankyrin repeats are tandemly repeated modules of about 33 amino acids described as L-shaped structures consisting of a beta-hairpin and two alpha-helices. Ankyrin repeats occur in a large number of functionally diverse proteins, mainly from eukaryotes, and are known to function as protein-protein interaction domains. [provided by RefSeq, Dec 2018]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L3Z8;B7ZLZ4;Q4F7X1;Q5QPD9;Q5QPE0;Q68DN8;Q6ZMX9;Q96NF0;Q9H1E0;Q9H442",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium",
        "go_biological_process": "GO:0042462 eye photoreceptor cell development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q9NVP4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99549-1",
        "uniprot_id": "MPP8_HUMAN",
        "mass": 97182.0,
        "length": 860,
        "protein_name": "M-phase phosphoprotein 8",
        "gene_name": "MPHOSPH8",
        "organism": "Human",
        "refseq_name": "M-phase phosphoprotein 8",
        "refseq_ac": "NP_059990",
        "gene_names_uniprotkb": "MPHOSPH8; MPP8",
        "gene_names_refseq": "HSMPP8; MPHOSPH8; TWA3; mpp8",
        "protein_names_uniprotkb": "M-phase phosphoprotein 8; Twa3; Two hybrid-associated protein 3 with RanBPM",
        "protein_names_refseq": "M-phase phosphoprotein 8; M-phase phosphoprotein, mpp8; two hybrid-associated protein 3 with RanBPM",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54737);  (R-HSA-9764725);  (R-HSA-9843970)",
        "pathway_count": 3,
        "publication_count": 106,
        "publication_id_list": "10655587;11237011;11912130;12559565;12700765;15542832;17081983;17130829;18318008;18452278;18669648;19413330;19651622;19664994;19664995;19690332;19691289;20068231;20418909;20871592;21406692;21419134;22022377;22086334;22158034;22658674;23186163;23416073;23466526;23481700;23532874;24275569;24715725;25576301;25645385;25728771;25892735;26022416;26154972;26212009;26992070;27600516;27732843;27862975;27920218;28228285;28446606;28581500;28832583;28834231;28904123;29211708;29242379;29557506;29632711;29728366;29729076;29769354;29786170;30315122;30410026;30429286;30487602;30779550;30898548;31154438;31530632;31844290;31848261;31937595;32157095;32161166;32357974;32502341;32897882;32976585;32983136;33009411;33141586;33144593;33298915;33592498;33596786;33608512;33691108;33717175;33912179;33936100;33968037;33981976;34171305;34211107;34415726;35008676;35051231;35138000;35292107;35580925;35851744;36241641;36284347;37938771;39013473;39489739;39638237;8885239",
        "class_list": "",
        "function": "Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:26022416, PubMed:28581500, PubMed:29211708). As part of the HUSH complex, promotes epigenetic repression of mobile genetic elements, such as retroviruses and transposable elements: the HUSH complex mainly represses LINE-1 (L1) retrotransposons that are still capable of transposition (PubMed:29211708). Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). MPHOSPH8 mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2, a chromatin remodeler that compacts chromatin (PubMed:26022416, PubMed:28581500). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). As part of the HUSH2 complex, promotes epigenetic repression of interferon-stimulated genes (PubMed:33144593, PubMed:39013473). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates silencing of E-cadherin (CDH1) and protocadherin genes in the nervous system (PubMed:20871592)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MPP8 Promotes Proliferation and Restrains Apoptosis in Osteosarcoma by Regulating p38alphaMAPK Pathway., [RefSeq, PubMed]; MPP8 mediates E-cadherin gene silencing and promotes breast tumour cell motility and invasion., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 28,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z6F9;Q5JPE5;Q5JTQ0;Q86TK3;Q96MK4;Q9BTP1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0062072 histone H3K9me2/3 reader activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000792 heterochromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045814 negative regulation of gene expression, epigenetic;GO:0032480 negative regulation of type I interferon production;GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation;GO:0140719 constitutive heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "Q99549-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P14649-1",
        "uniprot_id": "MYL6B_HUMAN",
        "mass": 22764.0,
        "length": 208,
        "protein_name": "Myosin light chain 6B",
        "gene_name": "MYL6B",
        "organism": "Human",
        "refseq_name": "myosin light chain 6B",
        "refseq_ac": "NP_001186558",
        "gene_names_uniprotkb": "MYL6B; MLC1SA",
        "gene_names_refseq": "MLC1SA; MYL6B",
        "protein_names_uniprotkb": "Myosin light chain 6B; MLC1sa; Myosin light chain 1 slow-twitch muscle A isoform; Smooth muscle and nonmuscle myosin light chain alkali 6B",
        "protein_names_refseq": "myosin alkali light chain 1 slow a; myosin light chain 1 slow a; myosin light chain 6B; myosin, light chain 6B, alkali, smooth muscle and non-muscle; myosin, light polypeptide 6B, alkali, smooth muscle and non-muscle; smooth muscle and non-muscle myosin alkali light chain 6B; smooth muscle and nonmuscle myosin light chain alkali 6B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:140465);  (R-HSA-445355)",
        "pathway_count": 2,
        "publication_count": 61,
        "publication_id_list": "10991994;11237011;11242081;11457814;11532985;11889009;12048254;14506282;14627618;15377279;156362;17055381;18974361;1930128;19380584;22421042;22778174;2304459;23834404;24872348;2526655;2602161;26154972;26362469;26992070;2764880;27679490;28741090;28834231;29439719;29508533;29557506;30315122;31492838;31844290;31848261;32157095;32350084;32488085;32983136;33592498;33633747;33691108;34087483;34357683;34932366;35051231;35154160;35318648;35561310;35580925;36010968;36284347;3780718;37938771;40596516;8858389;9481611;9598563;9600334;9855623",
        "class_list": "",
        "function": "Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]., [RefSeq]; Our results demonstrate that MYL6B is a putative tumor driver gene in HCC which could promote the degradation of p53 by enhancing its' MDM2-mediated ubiquitination. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory light chain of myosin. Does not bind calcium., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0003774 cytoskeletal motor activity;GO:0000146 microfilament motor activity",
        "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0016459 myosin complex;GO:0016460 myosin II complex",
        "go_biological_process": "GO:0006936 muscle contraction;GO:0030049 muscle filament sliding;GO:0007519 skeletal muscle tissue development",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "P14649-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96H12-1",
        "uniprot_id": "MSD3_HUMAN",
        "mass": 32363.0,
        "length": 275,
        "protein_name": "Myb/SANT-like DNA-binding domain-containing protein 3",
        "gene_name": "MSANTD3",
        "organism": "Human",
        "refseq_name": "myb/SANT-like DNA-binding domain-containing protein 3 isoform a",
        "refseq_ac": "NP_001185734",
        "gene_names_uniprotkb": "MSANTD3; C9orf30; L8",
        "gene_names_refseq": "C9orf30; L8; MSANTD3",
        "protein_names_uniprotkb": "Myb/SANT-like DNA-binding domain-containing protein 3",
        "protein_names_refseq": "Myb/SANT-like DNA-binding domain containing 3; UPF0439 protein C9orf30; myb/SANT-like DNA-binding domain-containing protein 3 isoform a; myb/SANT-like DNA-binding domain-containing protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91283)",
        "pathway_count": 1,
        "publication_count": 28,
        "publication_id_list": "11237011;15334068;17081983;18669648;19651622;20068231;23186163;27920218;28212443;28832583;29493099;29769354;30379171;30520817;30833945;31844290;32157095;32488085;33298915;33592498;33968037;33981976;34171305;35051231;35580925;36241641;38956325;39894887",
        "class_list": "",
        "function": "MSANTD3 rearrangement as a recurrent event in salivary gland AcCC Publication Status: Online-Only, [RefSeq, PubMed]; We find the HTN3-MSANTD3 gene fusion to be a recurrent event in acinic cell carcinoma with prominent serous differentiation and an indolent clinical course, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RC35;Q5T726;Q5T727;Q5T728",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q96H12-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q01449-1",
        "uniprot_id": "MLRA_HUMAN",
        "mass": 19448.0,
        "length": 175,
        "protein_name": "Myosin regulatory light chain 2, atrial isoform",
        "gene_name": "MYL7",
        "organism": "Human",
        "refseq_name": "myosin regulatory light chain 2, atrial isoform",
        "refseq_ac": "NP_067046",
        "gene_names_uniprotkb": "MYL7; MYL2A; MYLC2A",
        "gene_names_refseq": "MYL2A; MYL7; MYLC2A",
        "protein_names_uniprotkb": "Myosin regulatory light chain 2, atrial isoform; MLC-2a; MLC2a; Myosin light chain 2a; Myosin regulatory light chain 7",
        "protein_names_refseq": "MLC-2a; MLC2a; myosin light chain 2a; myosin regulatory light chain 2, atrial isoform; myosin regulatory light chain 7; myosin, light chain 7, regulatory; myosin, light polypeptide 7, regulatory",
        "tax_id": 9606,
        "disease": "hypertrophic cardiomyopathy 10 (Disease Ontology:DOID:0110316)",
        "pathway": " (hsa:58498);  (R-HSA-445355)",
        "pathway_count": 2,
        "publication_count": 38,
        "publication_id_list": "10991994;11237011;11242081;11457814;11532985;11889009;12048254;12847096;1429676;14506282;14627618;15377279;156362;17055381;18718080;18974361;1930128;19380584;22421042;22778174;23834404;24872348;2526655;26362469;2764880;27679490;28741090;29557506;29786170;35051231;3780718;39894887;41018975;8858389;9481611;9598563;9600334;9855623",
        "class_list": "",
        "function": "Dominant-negative effect of NMMHC-IIA is involved in the formation of inclusion bodies in Fechtner syndrome., [RefSeq, PubMed]; Nonmuscle Myosin Type IIA has distinct enzymatic properties that may be of importance in carrying out its cellular functions, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4L3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043197 dendritic spine;GO:0030016 myofibril;GO:0031672 A band",
        "go_biological_process": "GO:0060047 heart contraction;GO:0048738 cardiac muscle tissue development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q01449-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P50226-1",
        "uniprot_id": "ST1A2_HUMAN",
        "mass": 34310.0,
        "length": 295,
        "protein_name": "Sulfotransferase 1A2",
        "gene_name": "SULT1A2",
        "organism": "Human",
        "refseq_name": "sulfotransferase 1A2 isoform 1",
        "refseq_ac": "NP_001045",
        "gene_names_uniprotkb": "SULT1A2; STP2",
        "gene_names_refseq": "HAST4; P-PST 2; P-PST; ST1A2; STP2; SULT1A2; TSPST2",
        "protein_names_uniprotkb": "Sulfotransferase 1A2; 2.8.2.1; Aryl sulfotransferase 2; P-PST 2; Phenol sulfotransferase 2; Phenol-sulfating phenol sulfotransferase 2; ST1A2",
        "protein_names_refseq": "aryl sulfotransferase 2; arylamine sulfotransferase; phenol-preferring phenol sulfotransferase2; phenol-sulfating phenol sulfotransferase 2; phenolic-metabolizing (P) form of PST; sulfotransferase 1A2 isoform 1; sulfotransferase 1A2; sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2; thermostable phenol sulfotransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6799);  (R-HSA-156584)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "10199779;10224133;10503886;10512730;10762004;11077054;11154739;11237011;11457664;11739018;12039030;12145317;12372849;12889478;14622112;14672934;15358107;18606703;18672380;20417180;2268288;23479625;23481380;26169578;26455829;26992070;28904123;29908303;30429286;31154438;31848261;32265295;33981976;34171305;35051231;35580925;37142702;37217939;6139755;6770210;7581483;7678732;7779757;7889867;8033246;8185618;8661000;8697101;8912648;9034160;9119390;9463486;9501187;9566739;9852044",
        "class_list": "",
        "function": "Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adults. Erratum:[Sci Rep. 2023 May 31;13(1):8829. doi: 10.1038/s41598-023-35762-9. PMID: 37258596] Publication Status: Online-Only, [RefSeq, PubMed]; It metabolizes breast cancer drugs like afimoxifene and endoxifen by sulfation., [RefSeq, PubMed]; Suggest SULT1A1/1A2 play a central role in furfuryl alcohol bioactivation and the formation of hemoglobin adducts., [RefSeq, PubMed]; Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]., [RefSeq]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk., [UniProtKB]; The polymorphism of SULT1A2*2 is not associated with esophageal squamous cell carcinoma risk., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A9QY25;P78393;Q14CJ7",
        "ec_number_list": "2.8.2.-;2.8.2.1;2.8.2.2",
        "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0047894 flavonol 3-sulfotransferase activity;GO:0004062 aryl sulfotransferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0051923 sulfation;GO:0009309 amine biosynthetic process;GO:0006068 ethanol catabolic process;GO:0006805 xenobiotic metabolic process;GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "P50226-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P53602-1",
        "uniprot_id": "MVD1_HUMAN",
        "mass": 43405.0,
        "length": 400,
        "protein_name": "Diphosphomevalonate decarboxylase",
        "gene_name": "MVD",
        "organism": "Human",
        "refseq_name": "diphosphomevalonate decarboxylase",
        "refseq_ac": "NP_002452",
        "gene_names_uniprotkb": "MVD; MPD",
        "gene_names_refseq": "FP17780; MDDase; MPD; MVD; POROK7",
        "protein_names_uniprotkb": "Diphosphomevalonate decarboxylase; 4.1.1.33; MDDase; Mevalonate (diphospho)decarboxylase; Mevalonate pyrophosphate decarboxylase",
        "protein_names_refseq": "diphosphomevalonate decarboxylase; mevalonate (diphospho) decarboxylase; mevalonate decarboxylase; mevalonate pyrophosphate decarboxylase",
        "tax_id": 9606,
        "disease": "porokeratosis (Disease Ontology:DOID:3805); porokeratosis 7, multiple types (MONDO:MONDO:0013868)",
        "pathway": " (hsa:4597);  (R-HSA-2426168);  (R-HSA-446199);  (R-HSA-9969896)",
        "pathway_count": 4,
        "publication_count": 145,
        "publication_id_list": "10026212;10400691;10620343;10666321;10759542;10896663;11108725;11160603;11237011;11414710;12083769;12177166;12213788;12764144;1377680;14652022;14729858;14730012;14766201;14972328;16464866;16519518;16684881;17273964;17287340;17449569;17925399;18327899;18559965;18654640;18669648;18682402;18726356;18823933;18937434;1968462;19913121;20068231;20138239;20166139;20394422;20450493;20628086;20637498;20700148;20719759;20937905;21295283;21420384;21572394;22223895;22240719;22634312;23186163;23481700;24275569;24366607;24714562;25418920;25576301;25880248;26154972;26202976;26375851;26728094;26992070;27846572;27920218;28218747;28228285;28510447;28832583;28834231;29242379;29437277;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30833945;31092671;31154438;31207227;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32350084;32387766;32502341;32767669;32938616;32983136;33123756;33141586;33246356;33298915;33592498;33912179;33936100;33968037;34087483;34135477;34171305;34211107;34357683;34932366;35051231;35318648;35580925;36010968;36241641;38821050;5918048;6243292;7374371;7567999;7592729;7732023;7909540;7911016;7913309;8020941;8593458;8619637;8626466;8626488;8647822;8663599;8798690;8806705;8976377;9099716;9380443;9392419;9604010;9634533;9741684;9748295",
        "class_list": "",
        "function": "ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal recessive nonsyndromic hearing impairment., [RefSeq, PubMed]; Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Patients with disseminated superficial actinic porokeratosis (DSAP) and linear porokeratosis (LP) exhibit monoallelic germline mutations in genes encoding mevalonate pathway enzymes, such as MVD or MVK, [RefSeq, PubMed]; Recurrent MVD mutation in European patients with disseminated porokeratosis., [RefSeq, PubMed]; The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53Y65",
        "ec_number_list": "4.1.1.33",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0030544 Hsp70 protein binding;GO:0004163 diphosphomevalonate decarboxylase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0006695 cholesterol biosynthetic process;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol",
        "synthesized_glycan_count": 0,
        "hit_score": 14.8,
        "record_id": "P53602-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NQX1-1",
        "uniprot_id": "PRDM5_HUMAN",
        "mass": 73090.0,
        "length": 630,
        "protein_name": "PR domain zinc finger protein 5",
        "gene_name": "PRDM5",
        "organism": "Human",
        "refseq_name": "PR domain zinc finger protein 5 isoform 2",
        "refseq_ac": "NP_001287752",
        "gene_names_uniprotkb": "PRDM5; PFM2",
        "gene_names_refseq": "BCS2; PFM2; PRDM5",
        "protein_names_uniprotkb": "PR domain zinc finger protein 5; 2.1.1.-; PR domain-containing protein 5",
        "protein_names_refseq": "PR domain 5; PR domain containing 5; PR domain zinc finger protein 5 isoform 2; PR domain zinc finger protein 5",
        "tax_id": 9606,
        "disease": "brittle cornea syndrome 2 (Disease Ontology:DOID:0080729)",
        "pathway": " (hsa:11107)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "11237011;15077163;17636019;17699856;21664999;25576301;26992070;28834231;28904123;29485866;29557506;31154438;32387766;32938616;33739556;33968037;34509645;34757658;35051231;35580925;35799142;36127737",
        "class_list": "",
        "function": "Data suggest that epigenetic alteration of PRDM5 (e.g., methylation of its 5'-CpG island or trimethylation of Lys(27) of histone H3) likely plays a key role in the progression of gastrointestinal cancers and may be a useful molecular marker., [RefSeq, PubMed]; Deregulation of PRDM5 promotes cell proliferation by regulating JAK/STAT signaling pathway through SOCS1 in human lung adenocarcinoma., [RefSeq, PubMed]; Low expression of PRDM5 predicts poor prognosis of esophageal squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; More than meets the eye: Expanding and reviewing the clinical and mutational spectrum of brittle cornea syndrome. Review article, [RefSeq, PubMed]; PRDM5 caused G2/M arrest and apoptosis upon infection of tumor cells. These results suggest that inactivation of PRDM5 may play a role in carcinogenesis., [RefSeq, PubMed]; PRDM5 suppresses oesophageal squamous carcinoma cells and modulates 14-3-3zeta/Akt signalling pathway., [RefSeq, PubMed]; Results identify PRDM5, which acts as a sequence-specific, DNA binding transcription factor that targets hematopoiesis-associated protein-coding and microRNA genes, some of which are targets of Gfi1., [RefSeq, PubMed]; Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells., [UniProtKB, PubMed, PubMed, PubMed]; The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0VAI9;Q0VAJ0;Q6NXQ7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016604 nuclear body",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q9NQX1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86UW6-1",
        "uniprot_id": "N4BP2_HUMAN",
        "mass": 198801.0,
        "length": 1770,
        "protein_name": "NEDD4-binding protein 2",
        "gene_name": "N4BP2",
        "organism": "Human",
        "refseq_name": "NEDD4-binding protein 2 isoform 2",
        "refseq_ac": "NP_001305288",
        "gene_names_uniprotkb": "N4BP2; B3BP; KIAA1413",
        "gene_names_refseq": "B3BP; N4BP2",
        "protein_names_uniprotkb": "NEDD4-binding protein 2; 3.-.-.-; BCL-3-binding protein; N4BP2",
        "protein_names_refseq": "BCL-3-binding protein; NEDD4-binding protein 2 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55728)",
        "pathway_count": 1,
        "publication_count": 54,
        "publication_id_list": "11237011;12730195;16959974;17081983;17626640;18804481;19007248;19664994;22072629;23186163;25880248;26024233;26992070;28228285;28425186;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632711;29786170;30315122;30410026;31844290;32157095;32357974;32387766;32502341;32897882;32938616;32983136;33298915;33592498;33633747;33691108;33912179;33936100;33968037;33981976;34171305;34357683;34509645;34561969;34932366;35051231;35318648;35580925;36010968;36241641;40441874",
        "class_list": "",
        "function": "B3BP is a 5'-polynucleotide kinase, [RefSeq, PubMed]; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination (PubMed:12730195). May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon (PubMed:40441874)., [UniProtKB, PubMed, PubMed]; The N-terminal extended region of the Smr domain in the native B3bp may function as a regulatory region for the nicking endonuclease, [RefSeq, PubMed]; The solution structure of the functionally active Smr domain of the Bcl3-binding protein (also known as Nedd4-binding protein 2), a protein with unknown function that lacks other domains present in MutS proteins, is determined., [RefSeq, PubMed]; These data suggest that haplotype blocks ATTA and GTTG of N4BP2 is correlation with the risk of sporadic nasopharyngeal carcinoma in the Southern Chinese population. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]., [RefSeq]; We found that a burden of low-frequency coding variants in N4BP2, CDSN, PRTG, and AHRR were associated with increased risk of Nonsyndromic cleft lip with or without cleft palate (NSCL/P) . Low-frequency variants in other genes were associated with decreased risk of NSCL/P. These results demonstrate that low-frequency variants contribute to the genetic etiology of NSCL/P, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVR3;Q9NVK2;Q9P2D4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0004519 endonuclease activity;GO:0004520 DNA endonuclease activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q86UW6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q99550-1",
        "uniprot_id": "MPP9_HUMAN",
        "mass": 133024.0,
        "length": 1183,
        "protein_name": "M-phase phosphoprotein 9",
        "gene_name": "MPHOSPH9",
        "organism": "Human",
        "refseq_name": "M-phase phosphoprotein 9",
        "refseq_ac": "NP_073619",
        "gene_names_uniprotkb": "MPHOSPH9; MPP9",
        "gene_names_refseq": "MPHOSPH9; MPP-9; MPP9",
        "protein_names_uniprotkb": "M-phase phosphoprotein 9",
        "protein_names_refseq": "M-phase phosphoprotein 9",
        "tax_id": 9606,
        "disease": "multiple sclerosis (Disease Ontology:DOID:2377)",
        "pathway": " (hsa:10198)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;19879194;21399614;23186163;23481700;25576301;25892735;26375851;28228285;28649982;28832583;28834231;29242379;29769354;30375385;30379171;30524438;33174370;8885239",
        "class_list": "",
        "function": "M-Phase Phosphoprotein 9 upregulation associates with poor prognosis and activates mTOR signaling in gastric cancer., [RefSeq, PubMed]; MPP9 acts as a regulator of ciliogenesis by regulating the localization of CP110-CEP97 at the mother centriole. Publication Status: Online-Only, [RefSeq, PubMed]; Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385)., [UniProtKB, PubMed]; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0A0MTP3;A1L486;A6NEE2;B3KR87;Q9H976;U3KQ28",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0016020 membrane;GO:0005814 centriole",
        "go_biological_process": "GO:1902018 negative regulation of cilium assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q99550-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O94856-1",
        "uniprot_id": "NFASC_HUMAN",
        "mass": 150027.0,
        "length": 1347,
        "protein_name": "Neurofascin",
        "gene_name": "NFASC",
        "organism": "Human",
        "refseq_name": "neurofascin isoform 1 precursor",
        "refseq_ac": "NP_001005388",
        "gene_names_uniprotkb": "NFASC; KIAA0756",
        "gene_names_refseq": "NEDCPMD; NFASC; NF; NRCAML",
        "protein_names_uniprotkb": "Neurofascin",
        "protein_names_refseq": "neurofascin homolog; neurofascin isoform 1 precursor",
        "tax_id": 9606,
        "disease": "MASA syndrome (Disease Ontology:DOID:0060246); epilepsy (Disease Ontology:DOID:1826); neurodevelopmental disorder with central and peripheral motor dysfunction (MONDO:MONDO:0032698)",
        "pathway": " (hsa:23114);  (R-HSA-445095);  (R-HSA-447043);  (R-HSA-6798695)",
        "pathway_count": 4,
        "publication_count": 44,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;11152476;11222639;11237011;15491607;16597699;16904324;17223356;18669648;21047790;23090970;23481700;23584533;23650620;23897819;24190977;24497634;28228285;28657654;28832583;28940097;29242379;29288388;29557506;29741879;30124836;30850329;31945734;32387766;33141586;33392160;33592498;33968037;34087483;35051231;36241641;37074911;37217939;38253038;8692836;8922386;9371782;9804856",
        "class_list": "",
        "function": "Case report of two children with auditory neuropathy spectrum disorder related to a neurofascin (NFASC) gene variant., [RefSeq, PubMed]; Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions., [UniProtKB]; This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 8,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 8,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 9,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 39,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 34,
        "disease_count": 3,
        "glyco_site_count": 16,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNN8;B3KQZ1;B5MDP6;B5MDR6;B7ZMD8;Q149P5;Q5T2F0;Q5T2F1;Q5T2F2;Q5T2F3;Q5T2F4;Q5T2F5;Q5T2F6;Q5T2F7;Q5T2F9;Q5T2G0;Q5W9F8;Q68DH3;Q6ZQV6;Q7Z3K1;Q96HT1;Q96K50",
        "ec_number_list": "",
        "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0030424 axon;GO:0101003 ficolin-1-rich granule membrane;GO:0033010 paranodal junction",
        "go_biological_process": "GO:0042552 myelination;GO:0098609 cell-cell adhesion;GO:0007420 brain development;GO:0007422 peripheral nervous system development;GO:0007411 axon guidance",
        "synthesized_glycan_count": 0,
        "hit_score": 9.2,
        "record_id": "O94856-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BY44-1",
        "uniprot_id": "EIF2A_HUMAN",
        "mass": 64990.0,
        "length": 585,
        "protein_name": "Eukaryotic translation initiation factor 2A",
        "gene_name": "EIF2A",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 2A isoform 2",
        "refseq_ac": "NP_001305972",
        "gene_names_uniprotkb": "EIF2A; CDA02; MSTP004; MSTP089",
        "gene_names_refseq": "CDA02; EIF-2A; EIF2A; MST089; MSTP004; MSTP089",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2A; 65 kDa eukaryotic translation initiation factor 2A; eIF-2A",
        "protein_names_refseq": "65 kDa eukaryotic translation initiation factor 2A; eukaryotic translation initiation factor 2A isoform 2; eukaryotic translation initiation factor 2A, 65kDa",
        "tax_id": 9606,
        "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); sciatic neuropathy (Disease Ontology:DOID:11446); acute pancreatitis (Disease Ontology:DOID:2913); liver cirrhosis (Disease Ontology:DOID:5082); borna disease (Disease Ontology:DOID:5154); pneumonia (Disease Ontology:DOID:552); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:83939)",
        "pathway_count": 1,
        "publication_count": 103,
        "publication_id_list": "11237011;12133843;17081983;17287340;18212344;18452278;18669648;18707149;18767875;19413330;19415658;19651622;19664995;19690332;19913121;20058876;20068231;20166139;21406692;22645359;23186163;23481700;24275569;24366607;24715725;25576301;25645385;25880248;25892735;26024233;26154972;26375851;26992070;27600516;27846572;27920218;28218747;28228285;28510447;28514659;28832583;28834231;28855257;28904123;29242379;29317506;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30410026;31154438;31217245;31844290;31937595;32157095;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34185709;34211107;34229054;34561969;34725712;34932366;35051231;35251023;35494241;35580925;36010968;36284347;36581221;36689548;37581984;37602404;37938771;38433101;38665916;40307207",
        "class_list": "",
        "function": "Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed -1 ribosomal frameshifting., [RefSeq, PubMed]; Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]., [RefSeq]; To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1.DENR to deliver initiator tRNA to ribosomes. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MPS6;B4DF96;B4DQ14;D3DNI9;Q5QTR2;Q7Z4E9;Q8NFM1;Q96EW9;Q96K81",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003729 mRNA binding;GO:0045296 cadherin binding;GO:0000049 tRNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0072562 blood microparticle;GO:0005850 eukaryotic translation initiation factor 2 complex",
        "go_biological_process": "GO:0006417 regulation of translation;GO:0006413 translational initiation;GO:1990928 response to amino acid starvation;GO:0042255 ribosome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q9BY44-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TCD6-1",
        "uniprot_id": "PHOP2_HUMAN",
        "mass": 27769.0,
        "length": 241,
        "protein_name": "Pyridoxal phosphate phosphatase PHOSPHO2",
        "gene_name": "PHOSPHO2",
        "organism": "Human",
        "refseq_name": "pyridoxal phosphate phosphatase PHOSPHO2",
        "refseq_ac": "NP_001008489",
        "gene_names_uniprotkb": "PHOSPHO2",
        "gene_names_refseq": "PHOSPHO2",
        "protein_names_uniprotkb": "Pyridoxal phosphate phosphatase PHOSPHO2; 3.1.3.74",
        "protein_names_refseq": "pyridoxal phosphate phosphatase PHOSPHO2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:493911)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;16054448;23481700;24715725;29632046",
        "class_list": "",
        "function": "Models of PHOSPHO2 and PHOSPHO1 suggest subtle differences in the charge distributions around the putative substrate entry site and in the location of potential H-bond donors., [RefSeq, PubMed]; Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RC30;D3DPC7",
        "ec_number_list": "3.1.3.1;3.9.1.1;3.1.3.74;3.1.3.16",
        "go_molecular_function": "GO:0033883 pyridoxal phosphatase activity;GO:0046872 metal ion binding;GO:0016791 phosphatase activity",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8TCD6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P28698-1",
        "uniprot_id": "MZF1_HUMAN",
        "mass": 82055.0,
        "length": 734,
        "protein_name": "Myeloid zinc finger 1",
        "gene_name": "MZF1",
        "organism": "Human",
        "refseq_name": "myeloid zinc finger 1 isoform 2",
        "refseq_ac": "NP_001253962",
        "gene_names_uniprotkb": "MZF1; MZF; ZNF42; ZSCAN6",
        "gene_names_refseq": "MZF-1; MZF1B; MZF1; ZFP98; ZNF42; ZSCAN6",
        "protein_names_uniprotkb": "Myeloid zinc finger 1; MZF-1; Zinc finger and SCAN domain-containing protein 6; Zinc finger protein 42",
        "protein_names_refseq": "myeloid zinc finger 1 isoform 2; zinc finger and SCAN domain-containing protein 6; zinc finger protein 42 (myeloid-specific retinoic acid-responsive)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7593)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10974541;11237011;12427756;15541732;16950398;17081983;17851584;1860835;23186163;28018905;29540671;30301827;30622337;31366500;31844290;32449233;33968037;34405274;34773072;35254053;36010968;38058065;39894887",
        "class_list": "",
        "function": "Binds to target promoter DNA and functions as a transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development., [UniProtKB, PubMed, PubMed]; Cigarette smoke modulates binding of the transcription factor MZF1 to the VEGF promoter and regulates VEGF expression in dependence of genetic variation SNP 405., [RefSeq, PubMed]; Exogenous expression of the acidic domain of MZF1 repressed the binding of endogenous MZF1 to IGF1R promoter via blocking the interaction with ETS-like gene 1 (ELK1). This blockage not only caused MZF1 protein degradation, but also restrained ELK1 nuclear localization in high-level MZF1-expressing TNBC cells. MZF1, but not ELK1, was necessary for the retention of mesenchymal phenotype by repressing IGF1R promoter activity, [RefSeq, PubMed]; LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant Progression of Hepatocellular Carcinoma., [RefSeq, PubMed]; MZF1 mediates oncogene-induced senescence by promoting the transcription of p16(INK4A). Erratum:[Oncogene. 2025 Feb;44(4):272-275. doi: 10.1038/s41388-024-03229-4. PMID: 39613935], [RefSeq, PubMed]; Metallothionein 2A (MT2A)/myeloid zinc-finger 1 (MZF1) may serve as a prognostic marker and a therapeutic target for human gastric cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "M0QXU0;Q7Z729;Q96I71;Q9NRY0;Q9UBW2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "P28698-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NRC8-1",
        "uniprot_id": "SIR7_HUMAN",
        "mass": 44898.0,
        "length": 400,
        "protein_name": "NAD-dependent protein deacetylase sirtuin-7",
        "gene_name": "SIRT7",
        "organism": "Human",
        "refseq_name": "NAD-dependent protein deacetylase sirtuin-7",
        "refseq_ac": "NP_057622",
        "gene_names_uniprotkb": "SIRT7; SIR2L7",
        "gene_names_refseq": "SIR2L7; SIRT7",
        "protein_names_uniprotkb": "NAD-dependent protein deacetylase sirtuin-7; 2.3.1.-; 2.3.1.286; NAD-dependent protein deacylase sirtuin-7; Regulatory protein SIR2 homolog 7; SIR2-like protein 7",
        "protein_names_refseq": "NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacetylase sirtuin-7; NAD-dependent protein deacylase sirtuin-7; SIR2-like protein 7; regulatory protein SIR2 homolog 7; silent mating type information regulation 2, S.cerevisiae, homolog 7; sir2-related protein type 7; sirtuin type 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51547)",
        "pathway_count": 1,
        "publication_count": 80,
        "publication_id_list": "10873683;11237011;11953824;16079181;16618798;19174463;22586326;22722849;23481700;24129315;24207024;24397554;24715725;25418920;25880248;26154972;26811146;26867678;26907567;26992070;27287224;27436229;27846572;27862975;27997115;28147277;28218747;28426094;28655758;28790157;28832583;28886238;28904123;29242379;29351928;29393594;29437277;29493099;29508533;29557506;29632711;29728458;30315122;30420520;30540930;30653310;30944854;31075303;31154438;31226208;31542297;31844290;31848261;31937595;31998317;32157095;32357974;32502341;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33968037;34087483;34932366;35051231;35422493;35580925;35625898;35939806;36646384;38452583;38686489;38797153;38870055;38880736;40596516",
        "class_list": "",
        "function": "NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase, deglutarylase and dedecanoylase), depending on the context (PubMed:22722849, PubMed:26907567, PubMed:30653310, PubMed:31542297, PubMed:35939806). Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac) (PubMed:22722849, PubMed:30420520, PubMed:35939806). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression (PubMed:22722849, PubMed:30653310). H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts as a transcription repressor (PubMed:22722849). Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells (PubMed:22722849). Also able to mediate deacetylation of histone H3 at 'Lys-36' (H3K36Ac) in the context of nucleosomes (PubMed:30653310). Also mediates deacetylation of non-histone proteins, such as ATM, CDK9, DDX21, DDB1, FBL, FKBP5/FKBP51, GABPB1, RAN, RRP9/U3-55K and POLR1E/PAF53 (PubMed:24207024, PubMed:26867678, PubMed:28147277, PubMed:28426094, PubMed:28790157, PubMed:28886238, PubMed:30540930, PubMed:30944854, PubMed:31075303). Enriched in nucleolus where it stimulates transcription activity of the RNA polymerase I complex (PubMed:16618798, PubMed:19174463, PubMed:24207024). Acts by mediating the deacetylation of the RNA polymerase I subunit POLR1E/PAF53, thereby promoting the association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:16618798, PubMed:19174463, PubMed:24207024). In response to metabolic stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased RNA polymerase I transcription (PubMed:24207024). Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis (PubMed:19174463). Promotes pre-ribosomal RNA (pre-rRNA) cleavage at the 5'-terminal processing site by mediating deacetylation of RRP9/U3-55K, a core subunit of the U3 snoRNP complex (PubMed:26867678). Mediates 'Lys-37' deacetylation of Ran, thereby regulating the nuclear export of NF-kappa-B subunit RELA/p65 (PubMed:31075303). Acts as a regulator of DNA damage repair by mediating deacetylation of ATM during the late stages of DNA damage response, promoting ATM dephosphorylation and deactivation (PubMed:30944854). Suppresses the activity of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes by mediating deacetylation of DDB1, which prevents the interaction between DDB1 and CUL4 (CUL4A or CUL4B) (PubMed:28886238). Activates RNA polymerase II transcription by mediating deacetylation of CDK9, thereby promoting 'Ser-2' phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (PubMed:28426094). Deacetylates FBL, promoting histone-glutamine methyltransferase activity of FBL (PubMed:30540930). Acts as a regulator of mitochondrial function by catalyzing deacetylation of GABPB1 (By similarity). Regulates Akt/AKT1 activity by mediating deacetylation of FKBP5/FKBP51 (PubMed:28147277). Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability by mediating deacetylation and subsequent activation of DDX21, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase (PubMed:27436229, PubMed:27997115, PubMed:31542297). Acts as a protein depropionylase by mediating depropionylation of Osterix (SP7), thereby regulating bone formation by osteoblasts (By similarity). Acts as a histone deglutarylase by mediating deglutarylation of histone H4 on 'Lys-91' (H4K91glu); a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297). Acts as a histone desuccinylase: in response to DNA damage, recruited to DNA double-strand breaks (DSBs) and catalyzes desuccinylation of histone H3 on 'Lys-122' (H3K122succ), thereby promoting chromatin condensation and DSB repair (PubMed:27436229). Also promotes DSB repair by promoting H3K18Ac deacetylation, regulating non-homologous end joining (NHEJ) (By similarity). Along with its role in DNA repair, required for chromosome synapsis during prophase I of female meiosis by catalyzing H3K18Ac deacetylation (By similarity). Involved in transcriptional repression of LINE-1 retrotransposon via H3K18Ac deacetylation, and promotes their association with the nuclear lamina (PubMed:31226208). Required to stabilize ribosomal DNA (rDNA) heterochromatin and prevent cellular senescence induced by rDNA instability (PubMed:29728458). Acts as a negative regulator of SIRT1 by preventing autodeacetylation of SIRT1, restricting SIRT1 deacetylase activity (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF., [RefSeq, PubMed]; SIRT7 promotes mitochondrial biogenesis to render the adaptive resistance to MAPK inhibition in melanoma., [RefSeq, PubMed]; SIRT7: A potential prognostic marker and therapeutic target in gallbladder cancer., [RefSeq, PubMed]; Sirt7/HIC1 complex participates in hyperglycaemia-mediated EndMT via modulation of SDC1 expression in diabetic kidney disease and metabolic memory., [RefSeq, PubMed]; This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]., [RefSeq]; [Effect of SIRT7 on inhibiting the epithelial-mesenchymal transformation in pancreatic cancer cells and related mechanism]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2K0;B3KSU8;Q3MIK4;Q9NSZ6;Q9NUS6",
        "ec_number_list": "2.3.1.-;2.3.1.286;2.4.2.-",
        "go_molecular_function": "GO:0036055 protein-succinyllysine desuccinylase activity;GO:0061697 protein-glutaryllysine deglutarylase activity;GO:0097372 histone H3K18 deacetylase activity, NAD-dependent;GO:0003682 chromatin binding;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005731 nucleolus organizer region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:0061698 protein deglutarylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "Q9NRC8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P53985-1",
        "uniprot_id": "MOT1_HUMAN",
        "mass": 53944.0,
        "length": 500,
        "protein_name": "Monocarboxylate transporter 1",
        "gene_name": "SLC16A1",
        "organism": "Human",
        "refseq_name": "monocarboxylate transporter 1",
        "refseq_ac": "NP_001159968",
        "gene_names_uniprotkb": "SLC16A1; MCT1",
        "gene_names_refseq": "HHF7; MCT1D; MCT1; MCT; SLC16A1",
        "protein_names_uniprotkb": "Monocarboxylate transporter 1; MCT 1; Solute carrier family 16 member 1",
        "protein_names_refseq": "MCT 1; monocarboxylate transporter 1; solute carrier family 16 (monocarboxylate transporter), member 1; solute carrier family 16 (monocarboxylic acid transporters), member 1; solute carrier family 16, member 1 (monocarboxylic acid transporter 1)",
        "tax_id": 9606,
        "disease": "familial hyperinsulinemic hypoglycemia 7 (Disease Ontology:DOID:0070214); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); metabolic myopathy due to lactate transporter defect (MONDO:MONDO:0009501); ketoacidosis due to monocarboxylate transporter-1 deficiency (MONDO:MONDO:0014490)",
        "pathway": " (hsa:6566);  (R-HSA-210991);  (R-HSA-433692);  (R-HSA-5619070);  (R-HSA-9749641)",
        "pathway_count": 5,
        "publication_count": 152,
        "publication_id_list": "10220572;10434065;10493836;10590411;10880960;10921872;11237011;11581266;11719518;11943775;11944921;12115955;12558975;12616642;12657613;12946269;13741103;13929721;14707126;15118850;15505343;15901598;15901826;15911216;15917240;15946952;16258079;16260747;16837570;16858120;16943252;17081983;17127621;17322306;17482904;17701893;1783992;17996943;18452278;18582575;18669648;18691976;18707149;18767875;18991276;19369195;19413330;19651622;19691289;19836360;20068231;20166139;21406692;22674043;23186163;24265240;24275569;24390345;24715725;25390740;25418920;25576301;25645385;25840124;25892735;25957687;26154972;26992070;27397612;27920218;28228285;28514659;28677105;28832583;28834231;28855257;28904123;29242379;29314611;29393594;29557506;29769354;30315122;30418433;30429286;30484775;30524438;30779550;30833945;31092671;31154438;31217245;31222486;31530632;31611695;31844290;32119511;32157095;32161166;32350084;32357974;32387766;32502341;32897882;32938616;32946811;33298915;33333023;3342084;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34171305;34357683;34433824;34725712;35051231;35083852;35154160;35251023;35318648;35561310;35580925;36010968;36215666;36241641;3705620;37217939;38433101;38539084;38665916;38820650;39062697;5013373;5773090;5862532;6777177;6838677;7206363;7802672;7835905;8124722;9144407;931988;9360995;975718;9786900",
        "class_list": "",
        "function": "Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:32946811, PubMed:33333023). Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (PubMed:12946269, PubMed:33333023). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart (PubMed:32946811). Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition (PubMed:33333023)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis. Publication Status: Online-Only, [RefSeq, PubMed]; T-Allele Carriers of Mono Carboxylate Transporter One Gene Polymorphism rs1049434 Demonstrate Altered Substrate Metabolization during Exhaustive Exercise. Publication Status: Online-Only, [RefSeq, PubMed]; The N-terminal signature motif on the transporter MCT1 is critical for CD147-mediated trafficking., [RefSeq, PubMed]; The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]., [RefSeq]; To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1.DENR to deliver initiator tRNA to ribosomes. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 17,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q49A45;Q5T8R6;Q9NSJ9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0046943 carboxylic acid transmembrane transporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0015130 mevalonate transmembrane transporter activity;GO:0015129 lactate transmembrane transporter activity",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0032094 response to food;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion;GO:0007098 centrosome cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 15.5,
        "record_id": "P53985-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NZC4-1",
        "uniprot_id": "EHF_HUMAN",
        "mass": 34892.0,
        "length": 300,
        "protein_name": "ETS homologous factor",
        "gene_name": "EHF",
        "organism": "Human",
        "refseq_name": "ETS homologous factor isoform 3",
        "refseq_ac": "NP_001193544",
        "gene_names_uniprotkb": "EHF; ESE3B; ESE3; ESEJ",
        "gene_names_refseq": "EHF; ESE3B; ESE3; ESEJ",
        "protein_names_uniprotkb": "ETS homologous factor; ESE-3; ETS domain-containing transcription factor; Epithelium-specific Ets transcription factor 3; hEHF",
        "protein_names_refseq": "ESE3 transcription factor; ETS domain-containing transcription factor; ETS homologous factor isoform 3; epithelium-specific Ets transcription factor 3; hEHF",
        "tax_id": 9606,
        "disease": "abdominal aortic aneurysm (Disease Ontology:DOID:7693)",
        "pathway": " (hsa:26298)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10527851;10644770;11237011;11259407;12359648;12444029;16380452;17027647;25576301;25645385;25892735;29557506;29786170;32983136;33968037;34014591;34452885;34482266;35051231;35580925;36284347;38781975;38880187",
        "class_list": "",
        "function": "Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein-Barr virus-positive gastric cancer., [RefSeq, PubMed]; ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B., [RefSeq, PubMed]; Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis., [RefSeq, PubMed]; Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT Cells by Downregulating PSIP1 and NUCKS1., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Pancreatic cancer cell-derived microRNA-155-5p-containing extracellular vesicles promote immune evasion by triggering EHF-dependent activation of Akt/NF-kappaB signaling pathway., [RefSeq, PubMed]; This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]., [RefSeq]; Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DR08;D3DR10;E9PSB2;Q9H509;Q9UKF9;Q9Y5V4;Q9Y5V5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0030855 epithelial cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q9NZC4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UL63-1",
        "uniprot_id": "MKLN1_HUMAN",
        "mass": 84768.0,
        "length": 735,
        "protein_name": "Muskelin",
        "gene_name": "MKLN1",
        "organism": "Human",
        "refseq_name": "muskelin isoform 1",
        "refseq_ac": "NP_001138826",
        "gene_names_uniprotkb": "MKLN1",
        "gene_names_refseq": "MKLN1; TWA2",
        "protein_names_uniprotkb": "Muskelin",
        "protein_names_refseq": "muskelin 1, intracellular mediator containing kelch motifs; muskelin isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4289);  (R-HSA-9861718)",
        "pathway_count": 2,
        "publication_count": 88,
        "publication_id_list": "10640805;11237011;12559565;17467196;18387606;18710924;22223895;22499340;24714562;25418920;25576301;25645385;25880248;25892735;26154972;26375851;26811146;26992070;27397612;27600516;27846572;27862975;27920218;28218747;28228285;28411811;28649982;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29911972;30192525;30315122;30379171;30410026;30429286;30484775;30779550;30833945;31154438;31222486;31735643;31844290;31848261;32157095;32357974;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33462636;33592498;33633747;33691108;33717175;33912179;33968037;33981976;34087483;34185709;34357683;34932366;35051231;35318648;35561310;35580925;36010968;36241641;36284347;37549719;37938771;38460002;7757881",
        "class_list": "",
        "function": "Circular RNA MKLN1 promotes epithelial-mesenchymal transition in pulmonary fibrosis by regulating the miR-26a/b-5p/CDK8 axis in human alveolar epithelial cells and mice models., [RefSeq, PubMed]; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (By similarity). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (PubMed:18710924)., [UniProtKB, UniProtKB, PubMed, PubMed]; Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).[supplied by OMIM, Mar 2008]., [RefSeq]; The circRNA MKLN1 regulates autophagy in the development of diabetic retinopathy., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D1M8;A6NG43;Q9NSK4;Q9NUS8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007160 cell-matrix adhesion;GO:0030036 actin cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0008360 regulation of cell shape",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "Q9UL63-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P42898-1",
        "uniprot_id": "MTHR_HUMAN",
        "mass": 74597.0,
        "length": 656,
        "protein_name": "Methylenetetrahydrofolate reductase (NADPH)",
        "gene_name": "MTHFR",
        "organism": "Human",
        "refseq_name": "methylenetetrahydrofolate reductase (NADPH) isoform 1",
        "refseq_ac": "NP_001317287",
        "gene_names_uniprotkb": "MTHFR",
        "gene_names_refseq": "MTHFR",
        "protein_names_uniprotkb": "Methylenetetrahydrofolate reductase (NADPH); 1.5.1.53",
        "protein_names_refseq": "5,10-methylenetetrahydrofolate reductase (NADPH); methylenetetrahydrofolate reductase (NAD(P)H); methylenetetrahydrofolate reductase (NADPH) isoform 1",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); peripheral artery disease (Disease Ontology:DOID:0050830); non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); coarctation of the aorta (Disease Ontology:DOID:0051054); stroke (Disease Ontology:DOID:0051061); dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); thrombosis (Disease Ontology:DOID:0060903); myeloid neoplasm (Disease Ontology:DOID:0070004); spina bifida (Disease Ontology:DOID:0080016); neural tube defect (Disease Ontology:DOID:0080074); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); graft-versus-host disease (Disease Ontology:DOID:0081267); thrombophilia due to thrombin defect (Disease Ontology:DOID:0111907); migraine with aura (Disease Ontology:DOID:10024); osteonecrosis (Disease Ontology:DOID:10159); stomach cancer (Disease Ontology:DOID:10534); cardia cancer (Disease Ontology:DOID:10548); open-angle glaucoma (Disease Ontology:DOID:1067); kidney failure (Disease Ontology:DOID:1074); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sickle cell anemia (Disease Ontology:DOID:10923); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); urinary bladder cancer (Disease Ontology:DOID:11054); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); Budd-Chiari syndrome (Disease Ontology:DOID:11512); nephrosclerosis (Disease Ontology:DOID:11664); portal vein thrombosis (Disease Ontology:DOID:11695); factor VIII deficiency (Disease Ontology:DOID:12134); male infertility (Disease Ontology:DOID:12336); Graves' disease (Disease Ontology:DOID:12361); cardiovascular system disease (Disease Ontology:DOID:1287); carotid stenosis (Disease Ontology:DOID:13001); angle-closure glaucoma (Disease Ontology:DOID:13550); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); Down syndrome (Disease Ontology:DOID:14250); hypothyroidism (Disease Ontology:DOID:1459); thrombocytopenia (Disease Ontology:DOID:1588); retinal vein occlusion (Disease Ontology:DOID:1727); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); atherosclerosis (Disease Ontology:DOID:1936); rectal benign neoplasm (Disease Ontology:DOID:1984); hepatitis B (Disease Ontology:DOID:2043); nephroblastoma (Disease Ontology:DOID:2154); anemia (Disease Ontology:DOID:2355); renal artery disease (Disease Ontology:DOID:2388); thrombophilia (Disease Ontology:DOID:2452); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); familial Mediterranean fever (Disease Ontology:DOID:2987); lipid metabolism disorder (Disease Ontology:DOID:3146); ischemia (Disease Ontology:DOID:326); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); osteosarcoma (Disease Ontology:DOID:3347); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); mitral valve disease (Disease Ontology:DOID:61); migraine (Disease Ontology:DOID:6364); tetralogy of Fallot (Disease Ontology:DOID:6419); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); sporadic breast cancer (Disease Ontology:DOID:8029); cataract (Disease Ontology:DOID:83); chronic myeloid leukemia (Disease Ontology:DOID:8552); smallpox (Disease Ontology:DOID:8736); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); liver benign neoplasm (Disease Ontology:DOID:916); homocystinuria (Disease Ontology:DOID:9263); hyperhomocysteinemia (Disease Ontology:DOID:9279); cleft lip (Disease Ontology:DOID:9296); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypopituitarism (Disease Ontology:DOID:9406); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); aphthous stomatitis (Disease Ontology:DOID:9663); type 1 diabetes mellitus (Disease Ontology:DOID:9744); Meniere's disease (Disease Ontology:DOID:9849); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:4524);  (R-HSA-196757)",
        "pathway_count": 2,
        "publication_count": 109,
        "publication_id_list": "10091649;10323741;10347183;10536004;10679944;10978331;11237011;12370778;12937168;14688016;15534175;15729744;16024724;16171773;17129779;17308042;17962486;18497326;18583979;18987736;19424049;19948730;20236116;20498374;20661822;21163947;21238436;21876188;2248959;23217001;23393023;23409799;23481700;23626689;23649653;23773402;23934049;24146277;24155211;24366607;24733394;24748982;24769206;25736335;25818041;2605182;26992070;27614738;27920218;28218747;28228285;28820331;28832583;28834231;28855257;28904123;29437277;29557506;29891918;30192525;3053686;30862944;31154438;31844290;31848261;32157095;32423175;32488085;32502341;32658475;32938616;33053560;33163492;33633747;33717175;33968037;35051231;35318648;35580925;36241641;36284347;36581221;3801490;3871768;39310265;39325233;39340999;39414907;39448729;39894887;4066659;6323448;7564788;7647779;7726158;7852378;7920641;8218174;8522195;8662720;8826441;8895734;8940272;9545395;9545406;9680386;9719624;9753690;9781030",
        "class_list": "",
        "function": "Association between methylenetetrahydrofolate reductase C677T polymorphisms and male oligozoospermia, asthenozoospermia or oligoasthenozoospermia: a case-control study. Publication Status: Online-Only, [RefSeq, PubMed]; Association of Methylenetetrahydrofolate Reductase rs1801133 Polymorphism with osteoporosis and fracture risk in Taiwan. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine (PubMed:29891918). Represents a key regulatory connection between the folate and methionine cycles (Probable)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Clinical characteristics and thrombophilia associated gene variants in Egyptians with unprovoked venous thromboembolism: three centers experience. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic association and computational analysis of MTHFR gene polymorphisms rs1801131 and rs1801133 with breast cancer in the Bangladeshi population. Publication Status: Online-Only, [RefSeq, PubMed]; The MTHFR C677T/A1298C polymorphism is associated with increased risk of microangiopathy in type 2 diabetes mellitus: A systematic review and meta-analysis., [RefSeq, PubMed]; The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 98,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7A6;Q5SNW6;Q5SNW9;Q7Z6M6;Q8IU73;Q9UQR2",
        "ec_number_list": "1.5.1.53",
        "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0044877 protein-containing complex binding;GO:0004489 methylenetetrahydrofolate reductase [NAD(P)H] activity;GO:0050661 NADP binding",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0001666 response to hypoxia;GO:0001843 neural tube closure;GO:0070555 response to interleukin-1;GO:0009410 response to xenobiotic stimulus;GO:0043200 response to amino acid",
        "synthesized_glycan_count": 0,
        "hit_score": 11.2,
        "record_id": "P42898-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96RP9-1",
        "uniprot_id": "EFGM_HUMAN",
        "mass": 83471.0,
        "length": 751,
        "protein_name": "Elongation factor G, mitochondrial",
        "gene_name": "GFM1",
        "organism": "Human",
        "refseq_name": "elongation factor G, mitochondrial isoform 1",
        "refseq_ac": "NP_001295093",
        "gene_names_uniprotkb": "GFM1; EFG1; EFG; GFM",
        "gene_names_refseq": "COXPD1; EFG1; EFGM; EFG; EGF1; GFM1; GFM; hEFG1; mtEF-G1",
        "protein_names_uniprotkb": "Elongation factor G, mitochondrial; 3.6.5.-; EF-Gmt; Elongation factor G 1, mitochondrial; Elongation factor G1; hEFG1; mEF-G 1",
        "protein_names_refseq": "G translation elongation factor, mitochondrial; elongation factor G, mitochondrial isoform 1; mitochondrial elongation factor G1",
        "tax_id": 9606,
        "disease": "combined oxidative phosphorylation deficiency (Disease Ontology:DOID:0060286); combined oxidative phosphorylation deficiency 1 (Disease Ontology:DOID:0111474)",
        "pathway": " (hsa:85476);  (R-HSA-5389840)",
        "pathway_count": 2,
        "publication_count": 70,
        "publication_id_list": "10.1101/2023.09.13.557529;10353820;11237011;11374907;11735030;15358359;15537906;17160893;19524667;19608861;19716793;21119709;22172991;2250005;22544926;23186163;24275569;26154972;26741492;26811146;26992070;27090790;27600516;28218747;28228285;28446606;28510447;28649982;28832583;28834231;28904123;29242379;29393594;29437277;29557506;29632046;30524438;31092671;31844290;31848261;32119511;32157095;32265295;32387766;32602580;32737313;32897882;32938616;32983136;33141586;33210482;33298915;33465208;33592498;33691108;33717175;33912179;33936100;33968037;34087483;34357683;34725712;35051231;35580925;35703069;36010968;36215666;37938771;40596516;40914422",
        "class_list": "",
        "function": "Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. [provided by RefSeq, Jul 2008]., [RefSeq]; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis., [UniProtKB, HAMAP, PubMed]; Structural insights into mammalian mitochondrial translation elongation catalyzed by mtEFG1., [RefSeq, PubMed]; Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation. Publication Status: Online-Only, [RefSeq, PubMed]; Whole exome sequencing identifies a novel compound heterozygous GFM1 variant underlying developmental delay, dystonia, polymicrogyria, and severe intellectual disability in a Pakhtun family., [RefSeq, PubMed]; [Analysis of GFM1 gene mutations in a family with combined oxidative phosphorylation deficiency 1]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NCI9;B2RCB9;B3KRW1;Q6GTN2;Q96T39",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4;3.1.1.29;2.7.11.1;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0070125 mitochondrial translational elongation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q96RP9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O95425-1",
        "uniprot_id": "SVIL_HUMAN",
        "mass": 247746.0,
        "length": 2214,
        "protein_name": "Supervillin",
        "gene_name": "SVIL",
        "organism": "Human",
        "refseq_name": "supervillin isoform 1",
        "refseq_ac": "NP_003165",
        "gene_names_uniprotkb": "SVIL",
        "gene_names_refseq": "MFM10; SVIL",
        "protein_names_uniprotkb": "Supervillin; Archvillin; p205/p250",
        "protein_names_refseq": "archvillin; membrane-associated F-actin binding protein p205; p205/p250; supervillin isoform 1",
        "tax_id": 9606,
        "disease": "myofibrillar myopathy 10 (Disease Ontology:DOID:0112108)",
        "pathway": " (hsa:6840)",
        "pathway_count": 1,
        "publication_count": 85,
        "publication_id_list": "11237011;11792840;12711699;15302935;17081983;17322306;17525332;18077418;18088087;18212344;18220336;18452278;18639526;18669648;18691976;18767875;19007248;19109420;19651622;19664994;19664995;19683541;19691289;20058876;20068231;20166139;21406692;23186163;23301498;23382381;23481700;23750008;24129315;24275569;25576301;25645385;25684206;26992070;27397612;27862975;28832583;29242379;29493099;29508533;29557506;29789417;30379171;30429286;31154438;31844290;31848261;31998317;32157095;32161166;32468064;32488085;32502341;32582973;32779703;32897882;32938616;32983136;33392160;33537174;33691108;33862101;33968037;33981976;34087483;34171305;34185709;34405274;34480249;35051231;35254053;35318648;35580925;36010968;36284347;37938771;38665916;39302247;39531497;39534244;9867483",
        "class_list": "",
        "function": "A twinpair analysis indicates congenital scoliosis is associated with allelespecific methylation in the SVIL gene., [RefSeq, PubMed]; Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). In addition to its cytoskeletal activities, acts as a cofactor or scaffold for KDM1A, facilitating H3K9me2 demethylation and promoting gene activation, especially in neuronal contexts (PubMed:25684206)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Loss of supervillin causes myopathy with myofibrillar disorganization and autophagic vacuoles. Erratum:[Brain. 2021 Apr 12;144(3):e34. doi: 10.1093/brain/awaa412. PMID: 33313686], [RefSeq, PubMed]; May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Molecular basis of functional exchangeability between ezrin and other actin-membrane associated proteins during cytokinesis., [RefSeq, PubMed]; Supervillin Contributes to LPS-induced Inflammatory Response in THP-1 Cell-derived Macrophages., [RefSeq, PubMed]; Supervillin associates with androgen receptor and modulates its transcriptional activity., [RefSeq, PubMed]; Supervillin promotes tumor angiogenesis in liver cancer., [RefSeq, PubMed]; This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 44,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 76,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DRW9;M1J557;O60611;O60612;Q5VZK5;Q5VZK6;Q9H1R7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton",
        "go_biological_process": "GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0051014 actin filament severing;GO:0032467 positive regulation of cytokinesis;GO:0007519 skeletal muscle tissue development",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "O95425-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y5S2-1",
        "uniprot_id": "MRCKB_HUMAN",
        "mass": 194315.0,
        "length": 1711,
        "protein_name": "Serine/threonine-protein kinase MRCK beta",
        "gene_name": "CDC42BPB",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase MRCK beta isoform 1",
        "refseq_ac": "NP_006026",
        "gene_names_uniprotkb": "CDC42BPB; KIAA1124",
        "gene_names_refseq": "CDC42BPB; CHOCNS; MRCKB",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase MRCK beta; 2.7.11.1; CDC42-binding protein kinase beta; CDC42BP-beta; DMPK-like beta; MRCK beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; Myotonic dystrophy protein kinase-like beta",
        "protein_names_refseq": "CDC42 binding protein kinase beta (DMPK-like); CDC42BP-beta; DMPK-like beta; myotonic dystrophy kinase-related CDC42-binding kinase beta; myotonic dystrophy protein kinase-like beta; serine/threonine-protein kinase MRCK beta isoform 1; serine/threonine-protein kinase MRCK beta",
        "tax_id": 9606,
        "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); azoospermia (Disease Ontology:DOID:14227); Chilton-Okur-Chung neurodevelopmental syndrome (MONDO:MONDO:0859239)",
        "pathway": " (hsa:9578);  (R-HSA-9013148);  (R-HSA-9013406);  (R-HSA-9013409)",
        "pathway_count": 4,
        "publication_count": 287,
        "publication_id_list": "10.1101/2023.09.13.557529;10198171;10232922;10464238;10490598;10523665;10523675;10526156;10559246;10579713;10699171;10699464;10724160;10873802;10967094;11007481;11058585;11085924;11149925;11185749;11237011;11306516;11373293;11396949;11431473;11432776;11584276;11606631;11672528;11696321;11704860;11756552;11773441;11804587;11804589;11804590;11884391;11912491;11948177;12071859;12093360;12096337;12172552;12195014;12221096;12242347;12351724;12432077;12456725;12464619;12531887;12547822;12650940;12773384;12857875;12860998;12877655;12907671;14506234;14512443;15023524;15064355;15107133;15133129;15147912;15157669;15260990;15302923;15304341;15342493;15485661;15546864;15601624;15611138;15710388;15728722;15850391;15897194;16112081;16116428;16184169;16217026;16519628;16630611;16714282;16777452;16777849;16862148;16896804;16968698;17064668;17077126;17081983;17145773;17196961;17214551;17244649;17344846;17599059;17702745;17765681;17804252;17932950;17976533;18045877;18056264;18218625;18263588;18363964;18426980;18653540;18669648;18691976;18707149;18786931;18835169;18838382;18854160;18929667;19258391;19605563;19651622;19713215;19934221;20068231;20112406;20166139;20679435;21148482;21209280;21240187;21406692;21454492;21457715;21542010;21565175;21613211;21685891;21865595;21949762;21989057;22004470;22096251;22298643;22461490;22571869;22608513;22645359;22970203;22971344;23029280;23186163;23200924;23255595;23406282;23434736;23481700;23572525;23718289;24086303;24129315;24259668;24275569;24297911;24335996;24352656;24355937;24584464;24715725;24933155;24996924;25024229;25211221;25418920;25576301;25678704;25704760;25721503;25743393;25795300;25862245;25963737;26129894;26154972;26299518;26529257;26598554;26887924;26992070;27096001;27145964;27216196;27481945;27555588;27600516;27798618;27862975;27920218;28028151;28196833;28228285;28649982;28825699;28832583;28860633;28904123;29162624;29242379;29557506;29632046;29769354;29786170;30061681;30315122;30429286;30484775;30667325;30779550;30853411;31217245;31844290;31871319;32031333;32043305;32157095;32203420;32302585;32387766;32488085;32938616;32983136;33298915;33536006;33537174;33592498;33633747;33717175;33968037;33981976;34087483;34171305;34185709;34211107;34405274;34509645;35051231;35580925;36010968;36215666;36241641;36284347;37217939;38253038;38665916;39086134;7479768;7512369;7673236;7721814;7753201;8021274;8537347;8643598;8649427;8662891;8670801;8756646;8769096;8798539;8805223;8810315;8816443;8994827;9013646;9113980;9268338;9305890;9405671;9438849;9490638;9497316;9659915;9670022;9829970;9843499;9846874;9857026",
        "class_list": "",
        "function": "Analysis of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta, [RefSeq, PubMed]; De novo heterozygous missense and loss-of-function variants in CDC42BPB are associated with a neurodevelopmental phenotype., [RefSeq, PubMed]; Helicobacter pylori-induced gastric cancer is orchestrated by MRCKbeta-mediated Siah2 phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; Sequence variant in the CDC42BPB gene is potentially associated with Mullerian duct anomalies., [RefSeq, PubMed]; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The CDC42 effector protein MRCKbeta autophosphorylates on Threonine 1108., [RefSeq, PubMed]; This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]., [RefSeq]; Tumor-intrinsic CDC42BPB confers resistance to anti-PD-1 immune checkpoint blockade in breast cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A9JR72;Q2L7A5;Q86TJ1;Q9ULU5",
        "ec_number_list": "2.7.11.1;2.3.2.26;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;3.6.5.2;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;3.1.4.4;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;1.16.1.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005911 cell-cell junction",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0016477 cell migration;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 29.2,
        "record_id": "Q9Y5S2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BTC8-1",
        "uniprot_id": "MTA3_HUMAN",
        "mass": 67504.0,
        "length": 594,
        "protein_name": "Metastasis-associated protein MTA3",
        "gene_name": "MTA3",
        "organism": "Human",
        "refseq_name": "metastasis-associated protein MTA3 isoform a",
        "refseq_ac": "NP_001269684",
        "gene_names_uniprotkb": "MTA3; KIAA1266",
        "gene_names_refseq": "MTA3",
        "protein_names_uniprotkb": "Metastasis-associated protein MTA3",
        "protein_names_refseq": "metastasis associated gene family, member 3; metastasis-associated protein MTA3 isoform a; metastasis-associated protein MTA3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57504);  (R-HSA-3214815);  (R-HSA-427389);  (R-HSA-73762);  (R-HSA-8943724);  (R-HSA-9679191);  (R-HSA-9843940);  (R-HSA-9844594);  (R-HSA-9845323);  (R-HSA-9937850);  (R-HSA-9940951);  (R-HSA-9976102)",
        "pathway_count": 12,
        "publication_count": 202,
        "publication_id_list": "10082553;10087012;10204490;10330177;10444591;10449787;10748112;10904264;10913176;10922406;10926844;10970879;10978333;11237011;11250901;11378386;11509652;11545734;11739383;11742974;11781575;11909966;11959841;11959846;12032298;12183469;12393749;12419226;12504854;12705869;12724404;12869583;14536086;15454082;15456747;1547496;15516265;15643425;15701600;15882967;16115318;16186106;16415179;16418168;16428440;16522641;16567619;16676006;16702404;16707490;16954381;17211407;17318177;17646674;17662961;17873065;17974977;18082607;18172008;18391013;18487508;18571423;18656484;19440552;19884659;20223979;20233713;2028256;20516213;20523938;21289308;21406692;21490301;21587264;22128185;22398447;22401777;22552008;22684280;22814904;22926524;23186163;23239876;23287862;23361464;23641311;24252660;24272870;24307175;24385926;24397554;24554700;24584101;24714562;24715725;24718924;24920672;25150861;25274305;25576301;25593309;25645385;25728608;25753662;25801024;25880248;25892735;26002965;26028330;26101246;26375851;26768311;26811146;26813693;26910647;27418187;27418309;27600516;27633282;27732854;27806305;27846572;2805069;28273063;28425720;28533432;28904123;28977666;29042441;29393594;29437277;29557506;29769354;29945920;30045876;30122475;30134174;30201761;30228260;30281099;30315122;30327463;30379171;30410026;30429286;30706982;30980593;31048504;31217245;31289231;31330234;31427381;31746185;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;33264408;33283408;33298915;33537174;33592498;33691108;33717175;33744762;33912179;33936100;33968037;33981976;34087483;34171305;34357683;34405274;34932366;35051231;35561310;35580925;36008597;36010968;36241641;36284347;37217939;37938771;38359823;40914422;7491500;7513682;7801123;7969165;8769649;9016654;9150135;9427644;9512513;9651585;9790534;9804427;9885572",
        "class_list": "",
        "function": "Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12705869, PubMed:16428440, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Associated with Infantile hypertrophic pyloric stenosis risk, [RefSeq, PubMed]; Inhibition of MTA2 and MTA3 induces mesendoderm specification of human embryonic stem cells., [RefSeq, PubMed]; LncRNA HCG11 suppresses the growth of glioma by cooperating with the miR-4425/MTA3 axis., [RefSeq, PubMed]; The absence of MTA3 leads to aberrant expression of Snail, a master regulator of epithelial to mesenchymal transitions. This results in loss of expression of E-cadherin, causing changes in epithelial architecture and invasive growth., [RefSeq, PubMed]; The circ_0021093/miR-766-3p/MTA3 regulatory axis may be an effective therapeutic target for HCC., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
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        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NSP2;Q9ULF4",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016581 NuRD complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:2000736 regulation of stem cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 20.5,
        "record_id": "Q9BTC8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15049-1",
        "uniprot_id": "MLC1_HUMAN",
        "mass": 41141.0,
        "length": 377,
        "protein_name": "Membrane protein MLC1",
        "gene_name": "MLC1",
        "organism": "Human",
        "refseq_name": "membrane protein MLC1 isoform 1",
        "refseq_ac": "NP_055981",
        "gene_names_uniprotkb": "MLC1; KIAA0027; WKL1",
        "gene_names_refseq": "LVM; MLC1; MLC; VL",
        "protein_names_uniprotkb": "Membrane protein MLC1; Megalencephalic leukoencephalopathy with subcortical cysts protein 1",
        "protein_names_refseq": "megalencephalic leukoencephalopathy with subcortical cysts 1; megalencephalic leukoencephalopathy with subcortical cysts protein 1; membrane protein MLC1 isoform 1; membrane protein MLC1",
        "tax_id": 9606,
        "disease": "megalencephalic leukoencephalopathy with subcortical cysts (Disease Ontology:DOID:0080315); megalencephalic leukoencephalopathy with subcortical cysts 1 (Disease Ontology:DOID:0080316)",
        "pathway": " (hsa:23209)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "11237011;11254442;11326298;11935341;12189496;12665801;16652334;18477386;22328087;26154972;26992070;28218747;28832583;28904123;29242379;29437277;29557506;30192525;30315122;31844290;32350084;32387766;32897882;33141586;33392160;33912179;34357683;34509645;34918859;35051231;35440380;35580925;37821359;38141856",
        "class_list": "",
        "function": "A homozygous missense variant in the MLC1 gene underlies megalencephalic leukoencephalopathy with subcortical cysts in large kindred: Heterozygous carriers show seizure and mild motor function deterioration., [RefSeq, PubMed]; MLC1 Overexpression Inhibits Tumor Progression through PI3K/AKT Signal Pathway in Prostate Cancer., [RefSeq, PubMed]; Megalencephalic leukoencephalopathy with subcortical cysts protein-1: A new calcium-sensitive protein functionally activated by endoplasmic reticulum calcium release and calmodulin binding in astrocytes., [RefSeq, PubMed]; Prevalent MLC1 mutation causing autosomal recessive megalencephalic leukoencephalopathy in consanguineous Palestinian families., [RefSeq, PubMed]; The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]; Transmembrane protein mainly expressed in brain astrocytes that may play a role in transport across the blood-brain and brain-cerebrospinal fluid barriers (PubMed:22328087). Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx (PubMed:22328087). May function as regulatory protein of membrane protein complexes such as ion channels (Probable)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KW61;B7Z659;Q5JZ83;Q8TAG4;Q96RP5;Q9UGY8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol",
        "go_biological_process": "GO:0072584 caveolin-mediated endocytosis;GO:0015031 protein transport;GO:0071397 cellular response to cholesterol;GO:0016192 vesicle-mediated transport;GO:0032388 positive regulation of intracellular transport",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q15049-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q02045-1",
        "uniprot_id": "MYL5_HUMAN",
        "mass": 19534.0,
        "length": 173,
        "protein_name": "Myosin light chain 5",
        "gene_name": "MYL5",
        "organism": "Human",
        "refseq_name": "myosin light chain 5 isoform 1",
        "refseq_ac": "NP_002468",
        "gene_names_uniprotkb": "MYL5",
        "gene_names_refseq": "MYL5; MYLC2",
        "protein_names_uniprotkb": "Myosin light chain 5; MYLC2; MyLC-2; Myosin regulatory light chain 5; Superfast myosin regulatory light chain 2",
        "protein_names_refseq": "myosin light chain 5 isoform 1; myosin regulatory light chain 5; myosin, light chain 5, regulatory; myosin, light polypeptide 5, regulatory; superfast myosin regulatory light chain 2",
        "tax_id": 9606,
        "disease": "hypertrophic cardiomyopathy 10 (Disease Ontology:DOID:0110316)",
        "pathway": " (hsa:4636);  (R-HSA-445355)",
        "pathway_count": 2,
        "publication_count": 42,
        "publication_id_list": "10991994;11237011;11242081;11457814;11532985;11889009;12048254;1284596;14506282;14627618;15377279;156362;17055381;18974361;1930128;19380584;20201926;22421042;22778174;23834404;24872348;2526655;25892735;26362469;2764880;27679490;28228285;28741090;31844290;32157095;32357974;32502341;35561310;35580925;36846347;3780718;39894887;8858389;9481611;9598563;9600334;9855623",
        "class_list": "",
        "function": "MYL5 as a Novel Prognostic Marker is Associated with Immune Infiltrating in Breast Cancer: A Preliminary Study. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in fetal muscle and in adult retina, cerebellum, and basal ganglia. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IXL8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle",
        "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006937 regulation of muscle contraction",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q02045-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H9T3-1",
        "uniprot_id": "ELP3_HUMAN",
        "mass": 62259.0,
        "length": 547,
        "protein_name": "Elongator complex protein 3",
        "gene_name": "ELP3",
        "organism": "Human",
        "refseq_name": "elongator complex protein 3 isoform 3",
        "refseq_ac": "NP_001271151",
        "gene_names_uniprotkb": "ELP3",
        "gene_names_refseq": "ELP3; KAT9",
        "protein_names_uniprotkb": "Elongator complex protein 3; 2.3.1.311; hELP3; tRNA uridine(34) acetyltransferase",
        "protein_names_refseq": "elongation protein 3 homolog; elongator complex protein 3 isoform 3; elongator complex protein 3; protein lysine acetyltransferase ELP3; tRNA uridine(34) acetyltransferase",
        "tax_id": 9606,
        "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); familial dysautonomia (Disease Ontology:DOID:11589); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)",
        "pathway": " (hsa:55140);  (R-HSA-3214847)",
        "pathway_count": 2,
        "publication_count": 81,
        "publication_id_list": "10786633;10821277;11237011;11714725;11818576;15313887;15592455;15902492;16387653;16713582;18381289;18623064;18996918;19185337;19187765;20018852;22002106;22153374;22854966;24129315;24714562;24715725;25548167;25880248;25960406;26154972;26992070;27600516;27846572;27920218;28228285;28510447;28514659;28832583;28904123;29242379;29332244;29415125;29493099;29557506;29769354;29786170;29805303;30315122;30484775;31341009;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34229054;34509645;34561969;34932366;35051231;35251023;35561310;35580925;35722999;36010968;36241641;36284347;37640114;38665916;9427644;9558366;9880483",
        "class_list": "",
        "function": "Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis., [RefSeq, PubMed]; Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29415125). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (PubMed:29415125). Not a major acetyltransferase of tubulin (PubMed:22153374). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; Elongator activated migration and invasion of hepatocellular carcinoma cells by promoting the expression of MMP-2 and MMP-9 through the PI3K/AKT signaling pathway Publication Status: Online-Only, [RefSeq, PubMed]; Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer., [RefSeq, PubMed]; Study reveals a novel regulatory mechanism for ELP3, provides an example that acetyltransferase itself can be regulated by PTM, and suggests a potential target for ALK-positive cancer therapies. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DE19;B4DIG1;E2QRI5;Q53G84;Q6AWB0;Q9BVF7;Q9NVZ1",
        "ec_number_list": "2.3.1.311",
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0000049 tRNA binding;GO:0016407 acetyltransferase activity;GO:0106261 tRNA uridine(34) acetyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0033588 elongator holoenzyme complex",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006417 regulation of translation;GO:0030335 positive regulation of cell migration;GO:0001764 neuron migration;GO:0007417 central nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "Q9H9T3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13615-1",
        "uniprot_id": "MTMR3_HUMAN",
        "mass": 133619.0,
        "length": 1198,
        "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3",
        "gene_name": "MTMR3",
        "organism": "Human",
        "refseq_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 isoform c",
        "refseq_ac": "NP_066576",
        "gene_names_uniprotkb": "MTMR3; KIAA0371; ZFYVE10",
        "gene_names_refseq": "FYVE-DSP1; MTMR3; ZFYVE10",
        "protein_names_uniprotkb": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3; 3.1.3.95; FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; Myotubularin-related protein 3; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase; Zinc finger FYVE domain-containing protein 10",
        "protein_names_refseq": "FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphatase; FYVE domain-containing dual specificity protein phosphatase 1; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 isoform c; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase; zinc finger FYVE domain-containing protein 10; zinc finger, FYVE domain containing 10",
        "tax_id": 9606,
        "disease": "centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)",
        "pathway": " (hsa:8897);  (R-HSA-1632852);  (R-HSA-1660499)",
        "pathway_count": 3,
        "publication_count": 167,
        "publication_id_list": "10194451;10224048;10555148;10559940;10593988;10733931;10753883;10805725;10822173;11001876;11084340;11096062;11237011;11279162;11302699;11349134;11604140;11676921;11733541;11825910;11877430;11923287;12101241;12118066;12324459;12422219;12536145;12646134;12808147;12847086;14516276;14617813;14660569;15080793;15107860;15135396;15187094;15464023;15716355;15797027;15840652;16154996;16399794;16476736;16522682;16914545;16959974;16963840;16979564;17008356;17245604;17618624;17651088;18093523;18220336;18321988;18439900;18477386;18669648;18753295;19038970;19211835;19322194;19590496;19855179;19896968;19898463;20059746;20534812;20713597;20921139;21177865;21204784;21205641;21258367;21383122;21460621;21819378;22037487;22170151;22645359;22647598;22682742;23186163;23202584;23481700;23519112;23685627;23727157;23758345;23884233;24275569;24715725;24747438;24954904;25484072;25495341;25568151;25645385;25659891;26154972;26375851;26811146;26992070;27397612;28467828;28904123;29237092;29351928;29493099;29557506;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32488085;32531321;32690950;32938616;32983136;33198772;33392160;33592498;33717175;33912179;33968037;33981976;34357683;34561969;35051231;35154160;35251023;35561310;35580925;36010968;36215666;36284347;37014739;37414396;37910386;37938771;7608176;7624799;7628435;8640223;8681945;8723348;8769125;9094719;9113989;9211928;9286278;9295334;9367159;9428629;9514948;9516481;9524259;9593664;9660759;9660833;9736772;9811831;9830063",
        "class_list": "",
        "function": "Breast cancer risk is associated with the HULC rs7763881, MTMR3 rs12537 polymorphisms, and serum levels of HULC and MTMR3 in Egyptian patients., [RefSeq, PubMed]; Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Exosomal miR-1910-3p promotes proliferation, metastasis, and autophagy of breast cancer cells by targeting MTMR3 and activating the NF-kappaB signaling pathway., [RefSeq, PubMed]; Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; MTMR3 belongs to the myotubularin family of phosphoinositides phosphatases, [RefSeq, PubMed]; MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy., [RefSeq, PubMed]; MiR-100-5p is upregulated in multiple myeloma and involves in the pathogenesis of multiple myeloma through targeting MTMR3., [RefSeq, PubMed]; This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5PL26;A7MD32;Q9NYN5;Q9NYN6;Q9UDX6;Q9UEG3",
        "ec_number_list": "3.1.3.-;3.1.3.95;3.1.3.36;3.1.3.64;3.1.3.67;3.1.3.86",
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0019903 protein phosphatase binding;GO:0008138 protein tyrosine/serine/threonine phosphatase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0016236 macroautophagy;GO:0042149 cellular response to glucose starvation;GO:0060304 regulation of phosphatidylinositol dephosphorylation;GO:0006470 protein dephosphorylation;GO:0006661 phosphatidylinositol biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 17.2,
        "record_id": "Q13615-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15382-1",
        "uniprot_id": "RHEB_HUMAN",
        "mass": 20497.0,
        "length": 184,
        "protein_name": "GTP-binding protein Rheb",
        "gene_name": "RHEB",
        "organism": "Human",
        "refseq_name": "GTP-binding protein Rheb",
        "refseq_ac": "NP_005605",
        "gene_names_uniprotkb": "RHEB; RHEB2",
        "gene_names_refseq": "RHEB2; RHEB",
        "protein_names_uniprotkb": "GTP-binding protein Rheb; 3.6.5.-; Ras homolog enriched in brain",
        "protein_names_refseq": "GTP-binding protein Rheb; Ras homolog enriched in brain 2",
        "tax_id": 9606,
        "disease": "disease of metabolism (Disease Ontology:DOID:0014667); tuberous sclerosis (Disease Ontology:DOID:13515); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:6009);  (R-HSA-1632852);  (R-HSA-165159);  (R-HSA-166208);  (R-HSA-380972);  (R-HSA-5628897);  (R-HSA-8943724);  (R-HSA-9639288)",
        "pathway_count": 8,
        "publication_count": 269,
        "publication_id_list": "10.1101/2023.09.13.557529;10329961;10654941;10716435;10745013;10980602;11018120;11029283;11034341;11096062;11237011;11340051;11378386;11486029;11545734;11781575;11825910;11959846;12150926;12151408;12161445;12172553;12203114;12271141;12438239;12453409;12524439;12714747;12742462;12750860;12805220;12842888;12869586;12906785;13298683;13538944;14511394;14517248;14614828;14651849;14985505;15105503;15187094;15223;15308774;15314020;15340059;15579580;15589136;15728574;15755954;15809305;15854902;15878852;16075062;16098514;16115862;16140933;16413492;16418168;16636147;16676006;16702404;16728594;16760263;16839880;16943194;16959974;16963840;1715244;17277771;17298220;17386266;17470430;17486094;17510057;17517883;17540029;17618624;17873065;17974977;18172008;18198340;18321988;18344994;18372248;18391013;18439900;18487508;18497260;18604198;18692468;19113821;19211835;19322194;19439913;19440552;19487573;19590496;19822145;19855179;19884659;19898463;20059746;20080666;20182617;20233713;20351271;20378837;20381137;20516213;20713597;20921139;21177865;21205641;21258367;21289308;21336308;21383122;21460621;21602892;21750704;21819378;21958598;22002721;22053050;22128185;22170151;22363791;22445979;22575674;22682742;22819219;22980980;23202584;23287862;23328677;23685627;23723238;23727157;23775793;23884233;24066844;24081491;24095279;24366874;24383451;24397554;24529379;24718924;24747438;24954904;25259925;25263562;25418920;25457612;25484072;25561175;25567906;25568151;25576301;25579166;25645385;25728608;25816988;25819761;25880248;25961827;25963655;26449471;26586190;26622727;26652033;26811146;26910647;26972053;26992070;27308486;27487210;27600516;27648300;27846572;27920218;28063628;28066558;28199306;28199315;28218747;28228285;28832583;28834231;28904123;29053970;29056322;29123071;29236692;29242379;29314611;29393594;29416044;29437277;29557506;29632711;29786170;29789417;30061680;30181260;30315122;30429286;30514904;30524438;30651352;30779550;30833945;31844290;31848261;31998317;32157095;32350084;32357974;32387766;32470140;32488085;32502341;32897882;32938616;32983136;33157014;33298915;33392160;33537174;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34357683;34405274;34932366;35051231;35058442;35251023;35318648;35580925;35810594;35844793;36010968;36215666;36241641;37462942;37938771;38338768;38665916;38942776;5666113;7499430;7628435;7979252;7989588;8119488;8543055;8549768;8661031;8779952;9721431;9926927",
        "class_list": "",
        "function": "Design of negative-regulating proteins of Rheb/mTORC1 with much-reduced sizes of the tuberous sclerosis protein complex., [RefSeq, PubMed]; Intrinsically Disordered Membrane Anchors of Rheb, RhoA, and DiRas3 Small GTPases: Molecular Dynamics, Membrane Organization, and Interactions., [RefSeq, PubMed]; MiR-199a-3p/5p regulate tumorgenesis via targeting Rheb in non-small cell lung cancer. Erratum:[Int J Biol Sci. 2023 Jul 27;19(12):3830. doi: 10.7150/ijbs.86344. PMID: 37564201] Publication Status: Online-Only, [RefSeq, PubMed]; RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia., [RefSeq, PubMed]; Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12869586, PubMed:12906785, PubMed:15340059, PubMed:15854902, PubMed:16098514, PubMed:20381137, PubMed:22819219, PubMed:24529379, PubMed:29416044, PubMed:32470140, PubMed:33157014, PubMed:25816988). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:29236692, PubMed:33157014). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (PubMed:24529379). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]., [RefSeq]; Unraveling the Role of Ras Homolog Enriched in Brain (Rheb1 and Rheb2): Bridging Neuronal Dynamics and Cancer Pathogenesis through Mechanistic Target of Rapamycin Signaling. Review article Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 28,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWN6;D3DX13;Q53Y56;Q99444",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;2.7.11.1;3.6.1.-;7.1.2.2;2.7.10.2;2.7.11.31;1.11.1.-;3.6.5.4;5.2.1.8;2.7.11.26;2.1.1.-;3.6.-.-;2.3.2.27;3.6.1.15;3.1.26.n2;3.6.4.13;5.6.2.5;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane",
        "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0007165 signal transduction;GO:0016241 regulation of macroautophagy;GO:0007264 small GTPase-mediated signal transduction;GO:0031669 cellular response to nutrient levels",
        "synthesized_glycan_count": 0,
        "hit_score": 27.4,
        "record_id": "Q15382-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P53992-1",
        "uniprot_id": "SC24C_HUMAN",
        "mass": 118325.0,
        "length": 1094,
        "protein_name": "Protein transport protein Sec24C",
        "gene_name": "SEC24C",
        "organism": "Human",
        "refseq_name": "protein transport protein Sec24C",
        "refseq_ac": "NP_004913",
        "gene_names_uniprotkb": "SEC24C; KIAA0079",
        "gene_names_refseq": "SEC24C",
        "protein_names_uniprotkb": "Protein transport protein Sec24C; SEC24-related protein C",
        "protein_names_refseq": "SEC24 family, member C; SEC24 homolog C, COPII coat complex component; SEC24 related gene family, member C; SEC24-related protein C; protein transport protein Sec24C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9632);  (R-HSA-1655829);  (R-HSA-204005);  (R-HSA-2132295);  (R-HSA-5694530);  (R-HSA-9705671);  (R-HSA-983170)",
        "pathway_count": 7,
        "publication_count": 372,
        "publication_id_list": "10036229;10064069;10064083;10072072;10075675;10214955;10329445;10397761;10428864;10445031;10480952;10540230;10559958;10559959;10593899;10600378;10631941;10631952;10639150;10644685;10652252;10679020;10747087;10748235;10777614;10788476;10805775;10809954;10825291;10903204;10982397;11035026;11160214;11163199;11180106;11237011;11283257;11285137;11306556;11514579;11529500;11684289;11790530;11813165;11853874;11927603;12019269;12070132;12078484;12198549;12235121;12237308;12436109;12436110;12645939;12692549;12742663;12748383;12759408;14645851;14681859;14718384;14731593;15037235;15208624;15286279;15302935;15550381;15749704;15911768;15927284;16129679;16181339;16242130;16303754;16465444;16473882;16495487;16618111;16624868;16824007;16912714;17005010;17010120;17038314;17056546;17088086;17142755;17192411;17283181;17287728;17316621;17428803;17449569;17499046;17562788;17607000;17656363;17684057;18025080;18046453;18283111;18287528;18292509;18669648;18843296;18991276;19119025;19164740;19193869;19261456;19265014;19269366;19342655;19361863;19426129;1956401;19564404;19566487;19575639;19638414;19656848;19851281;20068231;20305658;2038058;20427317;20477988;20533886;20545907;20605430;20679433;20805473;20966969;21050182;21116285;2121367;21300897;21441454;21478858;21525241;21532587;21689688;21740066;21878990;2190094;22013193;22157747;22299025;22675024;22706990;22941947;23378591;23479643;23481700;23698585;23852824;23864707;2391366;24119662;24366607;2450918;24714562;24715725;24917561;25202031;25406594;25418920;25492864;25502872;25576301;25586378;25619252;25619253;25645385;25880248;26154972;26811146;26992070;27655845;27846572;27862975;27920218;28063628;28218747;28228285;28467828;28514659;28604694;28649982;28832583;28834231;28855257;28860189;28904123;29161034;29242379;29314611;29351928;29393594;29437277;29485866;29493099;29508533;29557506;29632046;29632711;29774024;29786170;30315122;30397120;30410026;30429286;30779550;30833945;30842662;31154438;31217245;31530632;31844290;31848261;31850239;31875875;31937595;31998317;32119511;32157095;32161166;32265295;32350084;32353859;32357974;32387766;32428392;32488085;32502341;32589897;32726803;32728199;32870666;32897882;32938616;32938750;32953130;32979938;32983136;33024073;33060197;33097660;33110251;33123756;33141586;33214551;33298915;33349665;33360543;33372174;33372854;33396605;33440148;33479219;33495715;33514628;33567255;33592498;33649557;33691108;33717175;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33912179;33936100;33963333;33968037;33989516;33990585;34019948;34021074;34054808;34084167;34087483;34110168;34142147;34166398;34171305;34229054;34239064;34290717;34341353;34357683;34375313;34400613;34439781;34452305;34471099;34502139;34509645;34597346;34725712;34932366;35051231;35102342;35138101;35154160;35254053;35580925;35643212;36010968;36241641;36284347;36581221;37051252;37217939;37938771;38253038;38665916;38838015;39531497;39534244;40596516;40617351;40914422;7481823;7592972;7642652;7650016;7667286;7876241;8046351;8134367;8145819;8148318;8156598;8221884;8313912;8342042;8397411;8415765;8620540;8642258;8663406;8674110;8687433;8849454;8909537;8939989;8947036;9075930;9094723;9150144;9177194;9202021;9307973;9311912;9312039;9395526;9472029;9488713;9497313;9539769;9545226;9605141;9606180;9634703;9647643;9659902",
        "class_list": "",
        "function": "Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Sec24C is an HIV-1 host dependency factor crucial for virus replication., [RefSeq, PubMed]; The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 28,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 28,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 28,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 49,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 29,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DZT4;Q8WV25",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000149 SNARE binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0070971 endoplasmic reticulum exit site",
        "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport;GO:0070863 positive regulation of protein exit from endoplasmic reticulum",
        "synthesized_glycan_count": 0,
        "hit_score": 40.2,
        "record_id": "P53992-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q14141-1",
        "uniprot_id": "SEPT6_HUMAN",
        "mass": 49717.0,
        "length": 434,
        "protein_name": "Septin-6",
        "gene_name": "SEPTIN6",
        "organism": "Human",
        "refseq_name": "septin-6 isoform B",
        "refseq_ac": "NP_055944",
        "gene_names_uniprotkb": "SEPTIN6; KIAA0128; SEP2; SEPT6",
        "gene_names_refseq": "SEP2; SEPT2; SEPT6; SEPTIN6; Septin-6",
        "protein_names_uniprotkb": "Septin-6",
        "protein_names_refseq": "septin 2; septin-6 isoform B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23157)",
        "pathway_count": 1,
        "publication_count": 108,
        "publication_id_list": "10501844;11237011;11809673;12096348;12665801;15774761;15915442;16093351;16914550;17229681;17287340;17525332;17637674;17803907;18047794;18446792;19145258;19413330;19608861;22706990;23186163;23481700;23783831;24714562;24715725;25418920;25502872;25576301;25588830;25810538;25880248;25892735;26154972;26375851;26552660;26728094;26811146;26929215;26992070;27543614;27600516;27846572;27862975;27920218;28063628;28228285;28346465;28446606;28514659;28649982;28832583;28834231;28855257;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30429286;30524438;31092671;31154438;31217245;31530632;31611695;31844290;31848261;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33592498;33691108;33912179;33936100;33968037;33981976;34116125;34171305;34357683;34561969;34932366;35051231;35154160;35318648;35580925;36010968;36241641;36284347;37217939;37756564;40307207;8760827",
        "class_list": "",
        "function": "An atomic model for the human septin hexamer by cryo-EM., [RefSeq, PubMed]; Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB]; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830)., [UniProtKB, PubMed, PubMed, PubMed]; MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, [RefSeq, PubMed]; This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JTK0;Q969W5;Q96A13;Q96GR1;Q96P86;Q96P87",
        "ec_number_list": "",
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding",
        "go_cellular_component": "GO:0097227 sperm annulus;GO:0005940 septin ring;GO:0032173 septin collar;GO:0005819 spindle;GO:0043679 axon terminus",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007010 cytoskeleton organization;GO:0000281 mitotic cytokinesis;GO:0008104 intracellular protein localization",
        "synthesized_glycan_count": 0,
        "hit_score": 11.1,
        "record_id": "Q14141-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P02808-1",
        "uniprot_id": "STAT_HUMAN",
        "mass": 7304.0,
        "length": 62,
        "protein_name": "Statherin",
        "gene_name": "STATH",
        "organism": "Human",
        "refseq_name": "statherin isoform b precursor",
        "refseq_ac": "NP_001009181",
        "gene_names_uniprotkb": "STATH",
        "gene_names_refseq": "STATH; STR",
        "protein_names_uniprotkb": "Statherin",
        "protein_names_refseq": "statherin isoform b precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6779)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "1663737;17313100;17389930;20068231;2373369;24715725;25128293;25418920;26375851;27452731;27600516;27893789;28228285;28649982;28837608;29242379;29314611;29393594;29493099;29557506;30429286;30524438;31154438;31606405;31844290;32157095;32357974;32373127;32387766;32983136;34078123;34087483;34171305;3426601;3476566;3502720;35051231;35318648;36395562;838735",
        "class_list": "",
        "function": "A negative screening of rare genetic variants in the ADIPOQ and STATH genes in cystic fibrosis., [RefSeq, PubMed]; Effects of statherin on intracellular calcium level and its subsequent related molecular alterations would give us new pathogenic aspect in oral carcinogenesis, [RefSeq, PubMed]; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface., [UniProtKB]; Statherin and alpha-amylase levels in saliva from patients with gingivitis and periodontitis., [RefSeq, PubMed]; The total protein and statherin in the in-vivo AEP were different between eroded and non-eroded tooth surfaces of the same patient Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NKE9;B2R4F8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030345 structural constituent of tooth enamel;GO:0046848 hydroxyapatite binding;GO:0030197 extracellular matrix constituent, lubricant activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0046541 saliva secretion;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0042742 defense response to bacterium;GO:0031214 biomineral tissue development;GO:0001503 ossification",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "P02808-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q16143-1",
        "uniprot_id": "SYUB_HUMAN",
        "mass": 14288.0,
        "length": 134,
        "protein_name": "Beta-synuclein",
        "gene_name": "SNCB",
        "organism": "Human",
        "refseq_name": "beta-synuclein isoform 1",
        "refseq_ac": "NP_001001502",
        "gene_names_uniprotkb": "SNCB",
        "gene_names_refseq": "SNCB",
        "protein_names_uniprotkb": "Beta-synuclein",
        "protein_names_refseq": "I(2)-synuclein; beta-synuclein isoform 1; beta-synuclein",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Pick's disease (Disease Ontology:DOID:11870); Lewy body dementia (Disease Ontology:DOID:12217); uveitis (Disease Ontology:DOID:13141); Parkinson's disease (Disease Ontology:DOID:14330); pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981); acute megakaryocytic leukemia (Disease Ontology:DOID:8761)",
        "pathway": " (hsa:6620);  (R-HSA-5660489)",
        "pathway_count": 2,
        "publication_count": 19,
        "publication_id_list": "10852916;1374386;17652097;19889641;21386983;21699177;22205345;26824222;28657654;29557506;32157095;35110380;35580925;36241641;37608748;38017278;38768940;8194594;9806846",
        "class_list": "",
        "function": "Blood beta-Synuclein and Neurofilament Light Chain During the Course of Prion Disease., [RefSeq, PubMed]; Data provide evidence for the role of beta-synuclein minor transcript variants in the development of complex diseases and provide new insights into the pathogenesis of Lewy body diseases., [RefSeq, PubMed]; Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease., [UniProtKB]; Plasma beta-synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy., [RefSeq, PubMed]; Serum beta-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]., [RefSeq]; Understanding Genetic Risks: Computational Exploration of Human beta-Synuclein nsSNPs and their Potential Impact on Structural Alteration., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IAX7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046914 transition metal ion binding;GO:0005509 calcium ion binding;GO:0004859 phospholipase inhibitor activity;GO:1903136 cuprous ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0043679 axon terminus;GO:0016234 inclusion body",
        "go_biological_process": "GO:0050808 synapse organization;GO:0007268 chemical synaptic transmission;GO:0048488 synaptic vesicle endocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q16143-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WUA4-1",
        "uniprot_id": "TF3C2_HUMAN",
        "mass": 100680.0,
        "length": 911,
        "protein_name": "General transcription factor 3C polypeptide 2",
        "gene_name": "GTF3C2",
        "organism": "Human",
        "refseq_name": "general transcription factor 3C polypeptide 2 isoform b",
        "refseq_ac": "NP_001030598",
        "gene_names_uniprotkb": "GTF3C2; KIAA0011",
        "gene_names_refseq": "GTF3C2; TF3C-beta; TFIIIC-BETA; TFIIIC110",
        "protein_names_uniprotkb": "General transcription factor 3C polypeptide 2; TF3C-beta; TFIIIC 110 kDa subunit; TFIIIC110; Transcription factor IIIC 110 kDa subunit; Transcription factor IIIC subunit beta",
        "protein_names_refseq": "TFIIIC 110 kDa subunit; general transcription factor 3C polypeptide 2 isoform b; general transcription factor 3C polypeptide 2; general transcription factor IIIC, polypeptide 2, beta 110kDa; transcription factor IIIC 110 kDa subunit; transcription factor IIIC subunit beta",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2976);  (R-HSA-749476);  (R-HSA-76061);  (R-HSA-76066)",
        "pathway_count": 4,
        "publication_count": 104,
        "publication_id_list": "11237011;11419933;12381659;16964243;17081983;17322306;18220336;18452278;18669648;18707149;18767875;19415658;1946469;19651622;19690332;20068231;21406692;22544926;23186163;23481700;2404611;24129315;24275569;24715725;25576301;25645385;25892735;26154972;26375851;26768311;26992070;27397612;27600516;27846572;27869121;27920218;28218747;28228285;28446606;28510447;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632711;29769354;29786170;30315122;30410026;30524438;30779550;31154438;31530632;31844290;31848261;31937595;31998317;32115405;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34405274;34509645;34932366;35051231;35580925;36010968;36241641;36284347;36581221;37938771;7568218;7729686;7995525;8407894;8423814;9171375;9312031",
        "class_list": "",
        "function": "Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1., [UniProtKB]; The transcription factor Sp1 modulates RNA polymerase III gene transcription by controlling BRF1 and GTF3C2 expression in human cells., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6W557;Q16632;Q9BWI7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000995 RNA polymerase III general transcription initiation factor activity",
        "go_cellular_component": "GO:0000127 transcription factor TFIIIC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0042791 5S class rRNA transcription by RNA polymerase III;GO:0042797 tRNA transcription by RNA polymerase III;GO:0006383 transcription by RNA polymerase III;GO:0006384 transcription initiation at RNA polymerase III promoter;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "Q8WUA4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14836-1",
        "uniprot_id": "TR13B_HUMAN",
        "mass": 31816.0,
        "length": 293,
        "protein_name": "Tumor necrosis factor receptor superfamily member 13B",
        "gene_name": "TNFRSF13B",
        "organism": "Human",
        "refseq_name": "tumor necrosis factor receptor superfamily member 13B",
        "refseq_ac": "NP_036584",
        "gene_names_uniprotkb": "TNFRSF13B; TACI",
        "gene_names_refseq": "CD267; CVID2; CVID; IGAD2; RYZN; TACI; TNFRSF13B; TNFRSF14B",
        "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 13B; Transmembrane activator and CAML interactor",
        "protein_names_refseq": "transmembrane activator and CAML interactor; tumor necrosis factor receptor 13B; tumor necrosis factor receptor superfamily member 13B",
        "tax_id": 9606,
        "disease": "immunoglobulin alpha deficiency (Disease Ontology:DOID:0060025); common variable immunodeficiency 2 (Disease Ontology:DOID:0081145); systemic lupus erythematosus (Disease Ontology:DOID:9074)",
        "pathway": " (hsa:23495);  (R-HSA-5669034)",
        "pathway_count": 2,
        "publication_count": 75,
        "publication_id_list": "10074428;10359578;10398604;10484778;10597252;10615125;10880535;10956646;10973284;11237011;11571266;11782012;11882293;11911831;12189164;12949498;14656435;15356117;15470070;15542592;16007086;16501042;1655907;17632511;18571443;18606301;20032458;20222921;20307208;20510730;20979233;21248752;21300286;22197273;22664871;22801960;23481700;24070496;24190977;24715725;25502872;26154972;27058226;27846572;28228285;28832583;29242379;29508533;29557506;29632046;29632711;31844290;31937595;31998317;32350084;32502341;33141586;33298915;33912179;33936100;34211107;34357683;34433824;34932366;35051231;35686370;36305039;37272840;37534633;39894887;7913952;8120384;8871664;9311921;9878548",
        "class_list": "",
        "function": "Features of Isoforms of Human Soluble TACI., [RefSeq, PubMed]; Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; TACI variants as underlying condition in autoimmune neutropenia: Description of four cases., [RefSeq, PubMed]; TNFRSF13B gene mutation in familial acute myeloid leukemia: A new piece in the complex scenario of hereditary predisposition?, [RefSeq, PubMed]; TNFRSF13B/TACI Mutations in Patients with Chronic Rhinosinusitis with Nasal Polyps., [RefSeq, PubMed]; The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8B0;B7Z6V8;Q32LX4;Q7Z6F5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0002250 adaptive immune response;GO:0002244 hematopoietic progenitor cell differentiation;GO:0030889 negative regulation of B cell proliferation;GO:0001782 B cell homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "O14836-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O14931-1",
        "uniprot_id": "NCTR3_HUMAN",
        "mass": 21593.0,
        "length": 201,
        "protein_name": "Natural cytotoxicity triggering receptor 3",
        "gene_name": "NCR3",
        "organism": "Human",
        "refseq_name": "natural cytotoxicity triggering receptor 3 isoform b precursor",
        "refseq_ac": "NP_001138938",
        "gene_names_uniprotkb": "NCR3; 1C7; LY117",
        "gene_names_refseq": "1C7; CD337; LY117; MALS; NCR3; NKp30",
        "protein_names_uniprotkb": "Natural cytotoxicity triggering receptor 3; Activating natural killer receptor p30; NK-p30; NKp30; Natural killer cell p30-related protein",
        "protein_names_refseq": "NK-p30; activating NK-A1 receptor; activating natural killer receptor p30; lymphocyte antigen 117; natural cytotoxicity triggering receptor 3 isoform b precursor; natural killer cell p30-related protein",
        "tax_id": 9606,
        "disease": "malaria (Disease Ontology:DOID:12365); hepatitis C (Disease Ontology:DOID:1883); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); malaria, mild, susceptibility to (MONDO:MONDO:0012202)",
        "pathway": " (hsa:259197);  (R-HSA-198933)",
        "pathway_count": 2,
        "publication_count": 114,
        "publication_id_list": "10202016;10499918;10562324;10746781;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12213321;12483297;12588680;14656967;14719373;14970179;15034010;15136729;15155468;15187158;15304001;15534202;15541655;15580655;15607800;15778510;15781451;15784725;15800062;15851719;15864273;16014749;16091383;16129954;16339513;16380601;16551255;16737824;16754721;16893496;16904340;16928187;17045824;17057721;17208487;17237375;17337780;18031695;18037897;18055229;18209062;18234675;18593354;18852879;19149696;19359216;19528259;19592130;20730098;21241660;21422170;21444796;21800138;21841309;21877119;22396535;22544926;23481700;23695528;23929856;24305946;25315772;25418920;25703557;25716998;26284469;26300885;28228285;28467828;28832583;28904123;29242379;29493099;29557506;31844290;32350084;32357974;32387766;32897882;33298915;33671836;33912179;34357683;34509645;34932366;35051231;35251023;36104113;37704951;38148073;7531291;7542404;8178173;8824804;8995416;9285412;9314561;9700512;9730896",
        "class_list": "",
        "function": "Altered NCR3 Splice Variants May Result in Deficient NK Cell Function in Renal Cell Carcinoma Patients., [RefSeq, PubMed]; Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional NK Cell-Engaging Antibodies Targeting EGFR and NKp30 Elicit Efficient Tumor Cell Killing and Proinflammatory Cytokine Release., [RefSeq, PubMed]; Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is in Contrast to BAG6 Only Marginally Released via Extracellular Vesicles. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0S8F2;B0S8F4;B0S8F5;O14930;O14932;O95667;O95668;O95669;Q5ST89;Q5ST90;Q5ST91;Q5ST92;Q5STA3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0140375 immune receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0002429 immune response-activating cell surface receptor signaling pathway;GO:0030101 natural killer cell activation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "O14931-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P84157-1",
        "uniprot_id": "MXRA7_HUMAN",
        "mass": 21466.0,
        "length": 204,
        "protein_name": "Matrix-remodeling-associated protein 7",
        "gene_name": "MXRA7",
        "organism": "Human",
        "refseq_name": "matrix-remodeling-associated protein 7 isoform 1",
        "refseq_ac": "NP_001008528",
        "gene_names_uniprotkb": "MXRA7",
        "gene_names_refseq": "MXRA7",
        "protein_names_uniprotkb": "Matrix-remodeling-associated protein 7",
        "protein_names_refseq": "matrix-remodeling-associated protein 7 isoform 1; matrix-remodeling-associated protein 7; matrix-remodelling associated 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:439921)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "11237011;18452278;18578522;18669648;19413330;19651622;23301498;24715725;29781547;30429286;31154438;31844290;32157095;32938616;33592498;33968037;33981976;34171305;35580925;36010968;36215666;36284347;36765476;37419299;38735126",
        "class_list": "",
        "function": "Critical role of MXRA7 in differentiation blockade in human acute promyelocytic leukemia cells., [RefSeq, PubMed]; MXRA7 gene might function as a negative modulator in psoriasis development when propsoriatic factors attack, presumably via expression alteration or redistribution of MXRA7 proteins in keratinocytes., [RefSeq, PubMed]; MXRA7 is involved in monocyte-to-macrophage differentiation., [RefSeq, PubMed]; [Effect of MXRA7 on the Biological Functions of Acute B Lymphoblastic Leukemia Cell Line REH]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0P5W3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane",
        "go_biological_process": "GO:0030219 megakaryocyte differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "P84157-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q765P7-1",
        "uniprot_id": "MTSS2_HUMAN",
        "mass": 79929.0,
        "length": 747,
        "protein_name": "Protein MTSS 2",
        "gene_name": "MTSS2",
        "organism": "Human",
        "refseq_name": "protein MTSS 2",
        "refseq_ac": "NP_612392",
        "gene_names_uniprotkb": "MTSS2; MTSS1L",
        "gene_names_refseq": "ABBA-1; ABBA1; ABBA; IDDOF; MTSS1L; MTSS2",
        "protein_names_uniprotkb": "Protein MTSS 2; ABBA-1; Actin-bundling with BAIAP2 homology protein 1; MTSS1-like protein",
        "protein_names_refseq": "MTSS1-like protein; MTSS1L, I-BAR domain containing; actin-bundling with BAIAP2 homology protein 1; metastasis suppressor 1-like; protein MTSS 2",
        "tax_id": 9606,
        "disease": "intellectual developmental disorder with ocular anomalies and distinctive facial features (Disease Ontology:DOID:0081301)",
        "pathway": " (hsa:92154)",
        "pathway_count": 1,
        "publication_count": 39,
        "publication_id_list": "11237011;14752106;18220336;18669648;19413330;19651622;20068231;20875796;23186163;24275569;24715725;25576301;25669885;26992070;27846572;28657654;28832583;28834231;29331515;29393594;29557506;29786170;30484775;31844290;32157095;32387766;32488085;32938616;33592498;33968037;34171305;34509645;35051231;35580925;36010968;36067766;36241641;36284347;40307207",
        "class_list": "",
        "function": "Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106)., [UniProtKB, PubMed]; The ABBA motif in cyclin A is required for its proper degradation in prometaphase through competing with BUBR1 for the same site on CDC20, [RefSeq, PubMed]; The recurrent de novo c.2011C>T missense variant in MTSS2 causes syndromic intellectual disability. Erratum:[Am J Hum Genet. 2022 Nov 3;109(11):2092. doi: 10.1016/j.ajhg.2022.10.001. PMID: 36332614], [RefSeq, PubMed]; These data indicates that the interaction between full-length Abba and Rac1 is implicated in membrane deformation and subjected to a growth factor-mediated regulation through the C-terminal sequence., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJI7;Q9BUA8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding",
        "go_cellular_component": "GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0032587 ruffle membrane;GO:0030864 cortical actin cytoskeleton",
        "go_biological_process": "GO:0007009 plasma membrane organization;GO:0061024 membrane organization;GO:0090630 activation of GTPase activity;GO:0036120 cellular response to platelet-derived growth factor stimulus;GO:0030031 cell projection assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q765P7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q10713-1",
        "uniprot_id": "MPPA_HUMAN",
        "mass": 58253.0,
        "length": 525,
        "protein_name": "Mitochondrial-processing peptidase subunit alpha",
        "gene_name": "PMPCA",
        "organism": "Human",
        "refseq_name": "mitochondrial-processing peptidase subunit alpha isoform 2",
        "refseq_ac": "NP_001269873",
        "gene_names_uniprotkb": "PMPCA; INPP5E; KIAA0123; MPPA",
        "gene_names_refseq": "Alpha-MPP; CLA1; CPD3; INPP5E; MAS2; P-55; PMPCA; SCAR2",
        "protein_names_uniprotkb": "Mitochondrial-processing peptidase subunit alpha; Alpha-MPP; Inactive zinc metalloprotease alpha; P-55",
        "protein_names_refseq": "Cerebellar ataxia-1; cerebellar ataxia 1 (autosomal recessive); inactive zinc metalloprotease alpha; inositol polyphosphate-5-phosphatase, 72 kD; mitochondrial matrix processing protease, alpha subunit; mitochondrial-processing peptidase subunit alpha isoform 2; mitochondrial-processing peptidase subunit alpha; peptidase, mitochondrial processing alpha subunit",
        "tax_id": 9606,
        "disease": "autosomal recessive cerebellar ataxia (Disease Ontology:DOID:0050950); autosomal recessive spinocerebellar ataxia 2 (Disease Ontology:DOID:0080061)",
        "pathway": " (hsa:23203);  (R-HSA-1268020);  (R-HSA-8949664);  (R-HSA-9837999)",
        "pathway_count": 4,
        "publication_count": 144,
        "publication_id_list": "11237011;11840567;11923310;12198491;14623864;14726512;15254020;15522782;15644312;15683237;15870080;16115876;16185709;16849325;17101804;17297443;17510655;17579211;18174896;18678864;19409522;19453276;19608861;19767391;19841671;19962426;20068231;20593814;21750375;22262461;22710082;23041349;23201127;23481700;23597483;23811401;23931759;24315374;24520911;24714562;24715725;25315652;25418920;25576301;25645385;25802875;25808372;25810538;25892735;26154972;26375851;26504172;26657514;26697887;26728094;26811146;26923599;26929215;26992070;27496948;27600516;27642048;27737933;27846572;27893789;27920218;28063628;28228285;28377575;28396416;28510447;28649982;28832583;28834231;28904123;29242379;29301859;29331515;29393594;29493099;29557506;29632046;29769354;29786170;29930882;29932645;30120231;30315122;30379171;30524438;30779550;31154438;31217245;31327635;31530632;31695197;31844290;31848261;32157095;32161166;32265295;32357974;32387766;32488085;32491259;32502341;32897882;32938616;33141586;33257573;33272776;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34704252;34725712;34932366;34943861;35051231;35318648;35580925;35870450;35885985;36010968;36241641;36629048;37938771;38665916;40596516;40914422;7623837",
        "class_list": "",
        "function": "A severe form of autosomal recessive spinocerebellar ataxia associated with novel PMPCA variants., [RefSeq, PubMed]; Functional coupling of presequence processing and degradation in human mitochondria., [RefSeq, PubMed]; Next-Generation Sequencing Identifies Novel PMPCA Variants in Patients with Late-Onset Dominant Optic Atrophy. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; The protein encoded by this gene is found in the mitochondrion, where it represents the alpha subunit of a proteolytic heterodimer. This heterodimer is responsible for cleaving the transit peptide from nuclear-encoded mitochondrial proteins. Defects in this gene are a cause of spinocerebellar ataxia, autosomal recessive 2. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DKL3;E7ET61;Q16639;Q5SXM9;Q8N513",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0017087 mitochondrial processing peptidase complex",
        "go_biological_process": "GO:0016485 protein processing;GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 14.9,
        "record_id": "Q10713-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H3H1-1",
        "uniprot_id": "MOD5_HUMAN",
        "mass": 52725.0,
        "length": 467,
        "protein_name": "tRNA dimethylallyltransferase",
        "gene_name": "TRIT1",
        "organism": "Human",
        "refseq_name": "tRNA dimethylallyltransferase isoform 2",
        "refseq_ac": "NP_001299620",
        "gene_names_uniprotkb": "TRIT1; IPT; MOD5",
        "gene_names_refseq": "COXPD35; GRO1; IPPT; IPTase; IPT; MOD5; TRIT1; hGRO1",
        "protein_names_uniprotkb": "tRNA dimethylallyltransferase; 2.5.1.75; IPP transferase; IPPT; IPTase; Isopentenyl-diphosphate:tRNA isopentenyltransferase; hGRO1; tRNA isopentenyltransferase 1",
        "protein_names_refseq": "IPP transferase; isopentenyl-diphosphate:tRNA isopentenyltransferase; tRNA dimethylallyltransferase isoform 2; tRNA dimethylallyltransferase, mitochondrial; tRNA isopentenylpyrophosphate transferase",
        "tax_id": 9606,
        "disease": "combined oxidative phosphorylation deficiency 35 (Disease Ontology:DOID:0111464); lung cancer (Disease Ontology:DOID:1324)",
        "pathway": " (hsa:54802);  (R-HSA-6782315);  (R-HSA-6787450)",
        "pathway_count": 3,
        "publication_count": 117,
        "publication_id_list": "10.1101/2023.09.13.557529;10430867;10982862;11027153;11111046;11237011;11560893;12403464;12456664;15509579;15861136;15870694;15994936;16043508;16424344;16826519;17071714;17081983;17145094;17693683;18077418;18567810;19017811;19414587;19651622;19732863;20068231;20123966;20308323;20354154;20584901;21059936;21131277;21890497;22344696;22591353;22608499;22995836;23042678;23048041;23097428;23186163;23349019;23381944;23604283;23625533;23814040;23929671;24126054;24204302;24715725;24901367;25261850;25404562;25418920;25552653;25576301;25880248;25892735;25916855;25925575;26160102;26310293;26768311;26811146;26992070;27055666;27846572;28185376;28832583;28904123;29390138;29393594;29508533;29557506;29760464;30315122;30379171;31481669;31844290;31848261;32047918;32088416;32157095;32357974;32387766;32502341;32897882;32938616;32948376;32983136;33141586;33298915;33392160;33592498;33691108;33717175;33968037;33981976;34509645;34774131;34932366;35051231;35251023;35580925;36010968;36047296;36049610;36215666;36241641;36284347;36581221;36610787;37217939;9430663;9512533;9851972",
        "class_list": "",
        "function": "Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37) (PubMed:11111046, PubMed:24126054, PubMed:24901367, PubMed:34774131). Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA) (PubMed:24126054). TRIT1 is therefore required for selenoprotein expression (PubMed:24126054)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; One TRIT1 haplotype, CCGT, was associated with lymph node metastasis., [RefSeq, PubMed]; TRIT1 defect leads to a recognizable phenotype of myoclonic epilepsy, speech delay, strabismus, progressive spasticity, and normal lactate levels. Review article, [RefSeq, PubMed]; TRIT1 deficiency: Two novel patients with four novel variants., [RefSeq, PubMed]; TRIT1 may control the levels of some tRNAs as well as their specific activity., [RefSeq, PubMed]; The rare allele of TRIT1 Phe202Leu SNP was approximately seven-fold more frequent in Asian than in Caucasian subjects and three additional SNPs in the TRIT1 gene showed ethnic differences in allelic frequencies GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A4X7;Q3T7B5;Q5QPK5;Q5QPK6;Q6IAC9;Q96FJ3;Q96L45;Q9NXT7",
        "ec_number_list": "2.5.1.75",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0052381 tRNA dimethylallyltransferase activity;GO:0016740 transferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006400 tRNA modification;GO:0070900 mitochondrial tRNA modification",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "Q9H3H1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P12829-1",
        "uniprot_id": "MYL4_HUMAN",
        "mass": 21565.0,
        "length": 197,
        "protein_name": "Myosin light chain 4",
        "gene_name": "MYL4",
        "organism": "Human",
        "refseq_name": "myosin light chain 4",
        "refseq_ac": "NP_001002841",
        "gene_names_uniprotkb": "MYL4; MLC1; PRO1957",
        "gene_names_refseq": "ALC1; AMLC; GT1; MYL4; PRO1957",
        "protein_names_uniprotkb": "Myosin light chain 4; Myosin light chain 1, embryonic muscle/atrial isoform; Myosin light chain alkali GT-1 isoform",
        "protein_names_refseq": "atrial myosin light chain 1; atrial, embryonic; myosin light chain 4; myosin, atrial/fetal muscle, light chain; myosin, light chain 4, alkali; myosin, light polypeptide 4, alkali",
        "tax_id": 9606,
        "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); cardiomyopathy (Disease Ontology:DOID:0050700); atrial fibrillation, familial, 18 (MONDO:MONDO:0015001)",
        "pathway": " (hsa:4635);  (R-HSA-390522)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "10747208;11237011;11557734;2027757;2129532;22898188;2308163;2458299;25807286;27066836;27742809;2849544;28834231;29242379;30315122;31735076;31844290;32350084;32502341;33592498;3417683;35051231;35251023;35580925;35874900;36241641;36284347;41018975",
        "class_list": "",
        "function": "A novel, heterozygous p.Glu11Lys mutation in the atrial-specific myosin light chain gene MYL4, caused atrial fibrillation. Publication Status: Online-Only, [RefSeq, PubMed]; A recessive frameshift mutation in MYL4 causes early-onset atrial fibrillation., [RefSeq, PubMed]; Metastable Atrial State Underlies the Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation., [RefSeq, PubMed]; Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Regulatory light chain of myosin. Does not bind calcium., [UniProtKB]; Relationship between Serum miR-106 and MYL4 Levels and the Prevalence, Risk Stratification, and Prognosis of Atrial Fibrillation. Publication Status: Online-Only, [RefSeq, PubMed]; The authors describe in a population approach a loss of function mutation in the myosin gene MYL4 that, in the homozygous state, is completely penetrant for early-onset AF. The finding may provide novel mechanistic insight into the pathophysiology of this complex arrhythmia., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DXJ7;P11783",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003785 actin monomer binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding;GO:0032038 myosin II heavy chain binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0031672 A band;GO:0016460 myosin II complex;GO:0016459 myosin complex",
        "go_biological_process": "GO:0006936 muscle contraction;GO:0060048 cardiac muscle contraction;GO:0002026 regulation of the force of heart contraction",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "P12829-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96S97-1",
        "uniprot_id": "MYADM_HUMAN",
        "mass": 35274.0,
        "length": 322,
        "protein_name": "Myeloid-associated differentiation marker",
        "gene_name": "MYADM",
        "organism": "Human",
        "refseq_name": "myeloid-associated differentiation marker",
        "refseq_ac": "NP_001018654",
        "gene_names_uniprotkb": "MYADM; PRO1110",
        "gene_names_refseq": "MYADM; SB135",
        "protein_names_uniprotkb": "Myeloid-associated differentiation marker; Protein SB135",
        "protein_names_refseq": "myeloid upregulated protein; myeloid-associated differentiation marker",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91663)",
        "pathway_count": 1,
        "publication_count": 67,
        "publication_id_list": "11237011;12075932;12975309;16303743;18578522;18669648;21325632;25576301;26940869;26992070;27846572;27862975;28832583;28904123;29242379;29314611;29493099;29508533;29557506;29786170;30315122;30429286;30484775;30524438;30779550;30833945;31154438;31611695;31844290;31848261;32157095;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33691108;33912179;33936100;33968037;34019948;34171305;34357683;34405274;34509645;34725712;34862427;35051231;35251023;35318648;35580925;36010968;36215666;36241641;36284347;37002207;37938771;38658526;38665916;38832511;40307207",
        "class_list": "",
        "function": "Cloning and characterization of human MYADM gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid., [RefSeq, PubMed]; MYADM binds human parechovirus 1 and is essential for viral entry. Publication Status: Online-Only, [RefSeq, PubMed]; Myeloid-associated differentiation marker (MYADM) regulates Rac1 targeting to ordered membranes required for cell spreading and migration., [RefSeq, PubMed]; Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity. Publication Status: Online-Only, [RefSeq, PubMed]; Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry. Publication Status: Online-Only, [RefSeq, PubMed]; Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular Remodeling by Regulating Myadm Transcript Stability., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RE58;Q542Z1;Q7Z507;Q8N9R4;Q96CS6;Q96SK9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0045121 membrane raft;GO:0001726 ruffle;GO:0030864 cortical actin cytoskeleton",
        "go_biological_process": "GO:0031579 membrane raft organization;GO:0044860 protein localization to plasma membrane raft;GO:0061028 establishment of endothelial barrier;GO:0010629 negative regulation of gene expression;GO:0030335 positive regulation of cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q96S97-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q15459-1",
        "uniprot_id": "SF3A1_HUMAN",
        "mass": 88886.0,
        "length": 793,
        "protein_name": "Splicing factor 3A subunit 1",
        "gene_name": "SF3A1",
        "organism": "Human",
        "refseq_name": "splicing factor 3A subunit 1",
        "refseq_ac": "NP_005868",
        "gene_names_uniprotkb": "SF3A1; SAP114",
        "gene_names_refseq": "PRP21; PRPF21; SAP114; SF3A120; SF3A1",
        "protein_names_uniprotkb": "Splicing factor 3A subunit 1; SAP 114; SF3a120; Spliceosome-associated protein 114",
        "protein_names_refseq": "SAP 114; pre-mRNA processing 21; pre-mRNA splicing factor SF3a (120 kDa subunit); spliceosome-associated protein 114; splicing factor 3 subunit 1; splicing factor 3A subunit 1; splicing factor 3a, subunit 1, 120kDa",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10291);  (R-HSA-72163);  (R-HSA-9770562);  (R-HSA-9918481);  (R-HSA-9943411)",
        "pathway_count": 5,
        "publication_count": 264,
        "publication_id_list": "10199952;10669729;10882114;11014198;11060040;11101529;11233976;11237011;11533230;11747608;11991638;12176931;12411573;12414731;12477934;12682017;14519844;14625303;14713954;14749727;14762106;15037765;15084397;15302935;15565158;15592455;15647753;16263726;16314458;16372014;16809785;16959974;17081983;17095540;17098193;17128255;17287340;17322306;17332742;17433364;17525332;17606899;17717186;18042460;18288197;18318008;18322460;18446792;18452278;18477386;18593880;18669648;18707149;19103666;19165350;19217410;19367720;19413330;19415658;19536130;19608861;19651622;19664994;19664995;19690332;20058876;20068231;20112406;20166139;20211137;20423332;20695905;20980672;21295486;21349847;21406692;21536652;2176635;21911577;22046413;22110043;22121020;22223895;22365833;22569126;22813749;22922743;22959432;22961380;22967762;23186163;23222130;23236153;23301498;23345524;23481700;23874216;24076191;24149845;24196718;24275569;24304693;24366607;24397554;24448447;24714562;24715725;24737827;24914973;25218447;25301780;25301781;25418920;25555158;25576301;2558966;25645385;25772364;25810538;25892735;26092250;26154972;26375851;26385511;26420826;26728094;26811146;26969736;26992070;27108190;27377154;27459055;27600516;27655845;27661449;27683217;27846572;27862975;27920218;28062851;28063628;28076346;28096519;28218747;28228285;28502770;28510447;28514659;28781166;28832583;28834231;28904123;28911096;29186539;29242379;29274231;29301961;29331515;29360106;29361316;29393594;29437277;29493099;29508533;29557506;29632046;29632711;2963332;29786170;29789417;29902443;30139799;30257008;30315122;30315277;30429286;30484775;30524438;30599162;30705154;30728453;30765414;30779550;30975767;31092671;31154438;31217245;31409651;31530632;31844290;31848261;31998317;32119511;32157095;32161166;32179686;32265295;32329775;32357974;32387766;32488085;32494006;32502341;32816001;32897882;32938616;32983136;33141586;33177556;33214551;33243851;33298915;33392160;33446560;33592498;33691108;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34301950;34509645;34725712;34822310;34932366;35051231;35083852;35132862;35138101;35177536;35215846;35251023;35318648;35385551;35561310;35580925;36010968;36215666;36241641;36284347;36797247;37094335;37217939;3757028;37938771;38665916;39302247;40596516;40914422;7489498;8566756;8608946;9016565;9242493;9512519;9524131;9539711;9659921;9671485;9701291;9731529",
        "class_list": "",
        "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Structural insights into recognition of SL4, the UUCG stem-loop, of human U1 snRNA by the ubiquitin-like domain, including the C-terminal tail in the SF3A1 subunit of U2 snRNP., [RefSeq, PubMed]; This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 4,
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        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PAW1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome;GO:0000389 mRNA 3'-splice site recognition",
        "synthesized_glycan_count": 0,
        "hit_score": 27.1,
        "record_id": "Q15459-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y6X9-1",
        "uniprot_id": "MORC2_HUMAN",
        "mass": 117823.0,
        "length": 1032,
        "protein_name": "ATPase MORC2",
        "gene_name": "MORC2",
        "organism": "Human",
        "refseq_name": "ATPase MORC2 isoform 1",
        "refseq_ac": "NP_001290185",
        "gene_names_uniprotkb": "MORC2; KIAA0852; ZCWCC1",
        "gene_names_refseq": "CMT2Z; DIGFAN; MORC2; ZCW3; ZCWCC1",
        "protein_names_uniprotkb": "ATPase MORC2; 3.6.1.-; MORC family CW-type zinc finger protein 2; Zinc finger CW-type coiled-coil domain protein 1",
        "protein_names_refseq": "ATPase MORC2 isoform 1; ATPase MORC2; zinc finger CW-type coiled-coil domain protein 1",
        "tax_id": 9606,
        "disease": "Charcot-Marie-Tooth disease axonal type 2Z (Disease Ontology:DOID:0110181); developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy (MONDO:MONDO:0030835)",
        "pathway": " (hsa:22880);  (R-HSA-75105);  (R-HSA-9843970)",
        "pathway_count": 3,
        "publication_count": 138,
        "publication_id_list": "10229681;11237011;12689621;13651131;1371749;15610069;15668256;15907797;16854592;17081983;17898086;17978863;18455495;18477386;18669648;19571038;19690332;20068231;20110259;20225202;20470824;20871592;21406692;22022377;22102020;22223895;22465940;22658674;23186163;23260667;23481700;23700546;23932781;24275569;24286864;24366607;24715725;25203508;25218447;25576301;26022416;26154972;26497905;26659848;26992070;27329773;27732843;27794525;27846572;27892461;27920218;28218747;28228285;28402445;28510447;28514659;28581500;28771897;28832583;28834231;28904123;29211708;29242379;29437277;29440755;29493099;29557506;29632711;29728366;29786170;29789417;30315122;30379171;30410026;30429286;30484775;30524438;30779550;30833945;31092671;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32401166;32502341;32693025;32897882;32938616;32976585;32983136;33009411;33141586;33298915;33537174;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34405274;34509645;34932366;34974534;35051231;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36967563;37737260;37892209;37938771;3805044;38227798;39048555;39589886;40596516;5810867;627544;7567999;7732023;7901201;7909540;7916016;9341199",
        "class_list": "",
        "function": "ATP-dependent chromatin remodeler essential for epigenetic silencing by the HUSH (human silencing hub) complex (PubMed:28581500, PubMed:29440755, PubMed:32693025). Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20110259, PubMed:20225202). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). Together with MPHOSPH8, mediates silencing of protocadherin genes in the nervous system (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Alternative polyadenylation reprogramming of MORC2 induced by NUDT21 loss promotes KIRC carcinogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Destabilization of microrchidia family CW-type zinc finger 2 via the cyclin-dependent kinase 1-chaperone-mediated autophagy pathway promotes mitotic arrest and enhances cancer cellular sensitivity to microtubule-targeting agents., [RefSeq, PubMed]; MORC2 regulates RBM39-mediated CDK5RAP2 alternative splicing to promote EMT and metastasis in colon cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase., [RefSeq, PubMed]; Novel Insights into the Role of Chromatin Remodeler MORC2 in Cancer. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNB1;Q9UF28;Q9Y6V2",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;2.3.3.8;3.6.5.-;7.6.2.1;2.3.2.27;2.1.1.366;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;2.7.4.3",
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016363 nuclear matrix",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006631 fatty acid metabolic process;GO:0006974 DNA damage response;GO:0140719 constitutive heterochromatin formation;GO:0141005 transposable element silencing by heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.7,
        "record_id": "Q9Y6X9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H410-1",
        "uniprot_id": "DSN1_HUMAN",
        "mass": 40067.0,
        "length": 356,
        "protein_name": "Kinetochore-associated protein DSN1 homolog",
        "gene_name": "DSN1",
        "organism": "Human",
        "refseq_name": "kinetochore-associated protein DSN1 homolog isoform 1",
        "refseq_ac": "NP_001138787",
        "gene_names_uniprotkb": "DSN1; C20orf172; MIS13",
        "gene_names_refseq": "C20orf172; DSN1; KNL3; MIS13; dJ469A13.2; hKNL-3",
        "protein_names_uniprotkb": "Kinetochore-associated protein DSN1 homolog",
        "protein_names_refseq": "DSN1 homolog, MIS12 kinetochore complex component; DSN1, MIND kinetochore complex component, homolog; DSN1, MIS12 kinetochore complex component; kinetochore null 3 homolog; kinetochore-associated protein DSN1 homolog isoform 1; kinetochore-associated protein DSN1 homolog",
        "tax_id": 9606,
        "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:79980);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5663220);  (R-HSA-6798695);  (R-HSA-68877);  (R-HSA-9648025)",
        "pathway_count": 9,
        "publication_count": 142,
        "publication_id_list": "10411507;10600384;10678165;10958683;11081627;11181178;11237011;11371342;11509732;11535616;11804586;12006501;12194817;12429848;12577064;12679384;12732141;12805219;12852857;14730319;15006353;15085137;15339662;15502821;15507212;15723797;15737063;15864301;15866170;15944396;16292343;16439214;16541025;16565220;16585270;16622419;16622420;16682347;16890222;16943183;17030981;17081983;17112726;17113138;17129783;17196341;17198702;17322306;1737036;17981135;18001770;18097444;18220336;18452278;18669648;18691976;18716626;18923426;19007248;19350017;19651622;19690332;19691289;19696148;19815554;19965387;20030946;20068231;20101212;20471944;20591975;21111234;21148482;21397845;21576392;21868368;21878504;21987589;22094460;22275430;22608513;22790947;22801782;22885700;23035123;23186163;23222643;23301498;23650620;23801653;24366607;24714562;24914801;25740311;25789526;25880248;26024233;26154972;26992070;27397612;27846572;28228285;28904123;29437277;29493099;29557506;30379171;30410026;31409757;31844290;32027339;32157095;32265295;32357974;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34238686;34260926;34932366;35051231;35509101;35561310;35580925;37938771;8692836;9649308;9649503;9892021",
        "class_list": "",
        "function": "DSN1 is a prognostic biomarker and correlated with clinical characterize in breast cancer., [RefSeq, PubMed]; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis., [UniProtKB, PubMed, PubMed]; SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 25,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DWT2;E1P5U9;Q5JW55;Q5JW56;Q9H8P4",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007059 chromosome segregation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.6,
        "record_id": "Q9H410-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H1K0-1",
        "uniprot_id": "RBNS5_HUMAN",
        "mass": 88870.0,
        "length": 784,
        "protein_name": "Rabenosyn-5",
        "gene_name": "RBSN",
        "organism": "Human",
        "refseq_name": "rabenosyn-5",
        "refseq_ac": "NP_001289307",
        "gene_names_uniprotkb": "RBSN; ZFYVE20",
        "gene_names_refseq": "KAREVS; MFANDO; RBSN; Rabenosyn-5; ZFYVE20",
        "protein_names_uniprotkb": "Rabenosyn-5; 110 kDa protein; FYVE finger-containing Rab5 effector protein rabenosyn-5; RAB effector RBSN; Zinc finger FYVE domain-containing protein 20",
        "protein_names_refseq": "110 kDa protein; FYVE finger-containing Rab5 effector protein rabenosyn-5; RAB effector RBSN; rabenosyn-5; zinc finger, FYVE domain containing 20",
        "tax_id": 9606,
        "disease": "Kariminejad neurodevelopmental syndrome (Disease Ontology:DOID:0061158); myelofibrosis, congenital, with anemia, neutropenia, developmental delay, and ocular abnormalities (MONDO:MONDO:0975797)",
        "pathway": " (hsa:64145);  (R-HSA-168138);  (R-HSA-983231)",
        "pathway_count": 3,
        "publication_count": 69,
        "publication_id_list": "11042108;11062261;11237011;11242053;11744692;11751636;11788822;11895428;11950885;12032298;12134158;12427746;14751759;15020713;15207506;15247287;15710388;16034420;16054028;16138080;1630448;17027967;17196961;17878374;18220336;18452278;18767875;18820679;19293402;19615748;19651622;20068231;20098723;20530532;20627800;21604257;218813;22308388;23186163;24275569;24342772;24855048;25233840;26375851;26845023;27862975;28832583;29242379;29784638;30059200;30620550;31492838;32157095;32350084;32488085;3409321;34357683;35051231;35652444;39531497;39534244;8662638;8816476;9065479;9230307;9326583;9331217;9422515;9927674",
        "class_list": "",
        "function": "A functional defect in the endocytic pathway resulting from a point mutation in Rabenosyn-5 leads to severe multi-organ disorder. Publication Status: Online-Only, [RefSeq, PubMed]; RABENOSYN separation-of-function mutations uncouple endosomal recycling from lysosomal degradation, causing a distinct Mendelian disorder., [RefSeq, PubMed]; Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Results demonstrate that even the structurally similar effector domains in rabenosyn-5 can achieve highly selective recognition of distinct subsets of Rab GTPases exclusively through interactions with the switch and interswitch regions, [RefSeq, PubMed]; This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DWY8;C9J4P5;Q3KP30;Q59EY8;Q8NAQ1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0032266 phosphatidylinositol-3-phosphate binding",
        "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0015031 protein transport;GO:0016197 endosomal transport;GO:0090160 Golgi to lysosome transport;GO:0034498 early endosome to Golgi transport;GO:1903358 regulation of Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "Q9H1K0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y2Z2-1",
        "uniprot_id": "MTO1_HUMAN",
        "mass": 79964.0,
        "length": 717,
        "protein_name": "5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial",
        "gene_name": "MTO1",
        "organism": "Human",
        "refseq_name": "5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial isoform c",
        "refseq_ac": "NP_001116698",
        "gene_names_uniprotkb": "MTO1; CGI-02",
        "gene_names_refseq": "CGI-02; COXPD10; MTO1",
        "protein_names_uniprotkb": "5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial; Mitochondrial tRNA translation optimization 1; Protein MTO1 homolog, mitochondrial",
        "protein_names_refseq": "5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial isoform c; 5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial; homolog of yeast Mto1; mitochondrial MTO1-3; mitochondrial translation optimization 1 homolog; protein MTO1 homolog, mitochondrial",
        "tax_id": 9606,
        "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); combined oxidative phosphorylation deficiency (Disease Ontology:DOID:0060286); combined oxidative phosphorylation deficiency 10 (Disease Ontology:DOID:0111480)",
        "pathway": " (hsa:25821);  (R-HSA-6787450)",
        "pathway_count": 2,
        "publication_count": 89,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12011058;12456664;15509579;15542390;16826519;18083107;19732863;21890497;22424782;22608499;22898188;23042678;23097428;23481700;23625533;23814040;23929671;24126054;24129315;24901367;25418920;25552653;25576301;25925575;26992070;27846572;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29390138;29393594;29437277;29493099;29557506;29632046;29760464;29786170;30315122;30379171;30410026;30484775;30524438;30779550;31154438;31217245;31222486;31530632;31844290;31848261;31937595;32047918;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32938616;33141586;33298915;33392160;33592498;33619562;33633747;33691108;33936100;33968037;34087483;34171305;34238206;34357683;34405274;34509645;34930906;34990597;35051231;36010968;36215666;36241641;37938771;9512533",
        "class_list": "",
        "function": "CircMTO1 inhibits ox-LDL-stimulated vascular smooth muscle cell proliferation and migration via regulating the miR-182-5p/RASA1 axis. Publication Status: Online-Only, [RefSeq, PubMed]; CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p/ZIC1 axis by regulating Wnt/beta-catenin signaling pathway and epithelial-to-mesenchymal transition. Publication Status: Online-Only, [RefSeq, PubMed]; Clinical and genetic analysis of combined oxidative phosphorylation defificiency-10 caused by MTO1 mutation., [RefSeq, PubMed]; Component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation (PubMed:29390138, PubMed:33619562). Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity (PubMed:29390138)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Identification of full-length cDNA and elucidation of genomic organization of the human MTO1 homolog, [RefSeq, PubMed]; Phenotype of non-syndromic deafness associated with the mitochondrial A1555G mutation is modulated by mitochondrial RNA modifying enzymes MTO1 and GTPBP3., [RefSeq, PubMed]; This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KQB5;Q5SWL2;Q5SWL3;Q5SWL4;Q8NDN7;Q8WZ57;Q96FE6;Q9BS06",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0050660 flavin adenine dinucleotide binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:7770010 GTPBP3-MTO1 complex;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0030488 tRNA methylation;GO:0070899 mitochondrial tRNA wobble uridine modification;GO:0002098 tRNA wobble uridine modification;GO:0008033 tRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "Q9Y2Z2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P2K8-1",
        "uniprot_id": "E2AK4_HUMAN",
        "mass": 186911.0,
        "length": 1649,
        "protein_name": "eIF-2-alpha kinase GCN2",
        "gene_name": "EIF2AK4",
        "organism": "Human",
        "refseq_name": "eIF-2-alpha kinase GCN2",
        "refseq_ac": "NP_001013725",
        "gene_names_uniprotkb": "EIF2AK4; GCN2; KIAA1338",
        "gene_names_refseq": "EIF2AK4; GCN2; PVOD2",
        "protein_names_uniprotkb": "eIF-2-alpha kinase GCN2; 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein",
        "protein_names_refseq": "GCN2 eIF2alpha kinase; GCN2-like protein; eIF-2-alpha kinase GCN2; general control nonderepressible 2",
        "tax_id": 9606,
        "disease": "pulmonary venoocclusive disease 2 (Disease Ontology:DOID:0081269); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:440275);  (R-HSA-9633012)",
        "pathway_count": 2,
        "publication_count": 81,
        "publication_id_list": "10504407;10982836;11018027;11237011;11677247;11691921;1400365;14630918;15385533;15775988;15781252;16026328;16989641;17081983;17267404;17344846;17726049;18285520;18669648;18691976;19369195;19608861;19651622;20068231;20361218;21406692;21849502;23186163;23269699;24135949;24292273;24310610;24366607;25329545;25576301;25589675;25880248;26102367;26709701;26811146;26992070;27526673;27846572;28904123;29383104;29413899;29437277;29557506;30804176;31844290;31848261;32157095;32357974;32387766;32488085;32610081;32938616;33289483;33298915;33592498;33912179;33968037;33981976;34509645;34561969;34932366;35051231;35318648;35561310;35580925;36010968;36241641;36284347;37199644;38175755;38281137;38776952;39316438;8336711;9211906;9528799",
        "class_list": "",
        "function": "(Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610)., [UniProtKB, PubMed]; Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes., [RefSeq, PubMed]; Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension., [RefSeq, PubMed]; GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]; Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions., [RefSeq, PubMed]; This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JEC4;Q69YL7;Q6DC97;Q96GN6;Q9H5K1;Q9NSQ3;Q9NSZ5;Q9UJ56",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;4.2.99.18;2.3.1.-;3.6.5.3;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0000049 tRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome",
        "go_biological_process": "GO:0070417 cellular response to cold;GO:0006468 protein phosphorylation;GO:0007612 learning;GO:0045665 negative regulation of neuron differentiation;GO:0051607 defense response to virus",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "Q9P2K8-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UL68-1",
        "uniprot_id": "MYT1L_HUMAN",
        "mass": 133043.0,
        "length": 1186,
        "protein_name": "Myelin transcription factor 1-like protein",
        "gene_name": "MYT1L",
        "organism": "Human",
        "refseq_name": "myelin transcription factor 1-like protein isoform 1",
        "refseq_ac": "NP_001289981",
        "gene_names_uniprotkb": "MYT1L; KIAA1106",
        "gene_names_refseq": "MRD39; MYT1L; NZF1; ZC2H2C2; ZC2HC4B; myT1-L",
        "protein_names_uniprotkb": "Myelin transcription factor 1-like protein; MyT1-L; MyT1L",
        "protein_names_refseq": "myelin transcription factor 1-like protein isoform 1; myelin transcription factor 1-like protein; neural zinc finger transcription factor 1",
        "tax_id": 9606,
        "disease": "autosomal dominant intellectual developmental disorder 39 (Disease Ontology:DOID:0070069)",
        "pathway": " (hsa:23040)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;18940311;21048971;23033978;23160955;23918370;29393594;29557506;29632711;34748075;34946857;36782060;37188826",
        "class_list": "",
        "function": "2p25.3 microduplications involving MYT1L: further phenotypic characterization through an assessment of 16 new cases and a literature review. Review article, [RefSeq, PubMed]; Co-Occurrence of Fragile X Syndrome with a Second Genetic Condition: Three Independent Cases of Double Diagnosis. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that reintroduction of A2BP1 or Myt1L in glioblastoma multiforme (GBM) cell lines and glioma stem cells profoundly inhibited tumorigenesis., [RefSeq, PubMed]; MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention., [RefSeq, PubMed]; MYT1L-associated neurodevelopmental disorder: description of 40 new cases and literature review of clinical and molecular aspects., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Results indicate that MYT1L may be a potential risk gene for major depressive disorder in the Chinese Han population GeneRIF: Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017]., [RefSeq]; Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 5,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 67,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7E2C7;B2RP54;Q6IQ17;Q9UPP6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030182 neuron differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q9UL68-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UIF7-1",
        "uniprot_id": "MUTYH_HUMAN",
        "mass": 60069.0,
        "length": 546,
        "protein_name": "Adenine DNA glycosylase",
        "gene_name": "MUTYH",
        "organism": "Human",
        "refseq_name": "adenine DNA glycosylase isoform 3",
        "refseq_ac": "NP_001041637",
        "gene_names_uniprotkb": "MUTYH; MYH",
        "gene_names_refseq": "MUTYH; MYH",
        "protein_names_uniprotkb": "Adenine DNA glycosylase; 3.2.2.31; MutY homolog; hMYH",
        "protein_names_refseq": "A/G-specific adenine DNA glycosylase; adenine DNA glycosylase isoform 3; mutY homolog; mutY-like protein",
        "tax_id": 9606,
        "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); familial adenomatous polyposis 2 (Disease Ontology:DOID:0080410); stomach cancer (Disease Ontology:DOID:10534); stomach carcinoma (Disease Ontology:DOID:5517)",
        "pathway": " (hsa:4595)",
        "pathway_count": 1,
        "publication_count": 74,
        "publication_id_list": "10684930;11237011;11818965;12056405;12606733;12853198;15273732;15366000;16134147;16287072;16557584;16941501;18091433;18491316;18515411;18612690;19953527;20418187;20843780;20848659;22922830;23481700;24377541;25418920;25505266;25820570;25892735;26154972;26694661;26811146;27600516;27920218;28063628;28218747;28649982;28832583;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29769354;30315122;30410026;31844290;31848261;32157095;32161166;32357974;32387766;32897882;32938616;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34405274;34509645;35051231;35580925;36241641;36581221;38062336;38071180;38394468;38790183;8682794",
        "class_list": "",
        "function": "Adenine glycosylase active on G-A mispairs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Breast cancers in monoallelic MUTYH germline mutation carriers have clinicopathological features overlapping with those in BRCA1 germline mutation carriers., [RefSeq, PubMed]; Effect of a single nucleotide polymorphism (SNP) in the MYH gene on the difference in the expression levels of its products, [RefSeq, PubMed]; Exploring the Role of the MUTYH Gene in Breast, Ovarian and Endometrial Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Multiple colorectal adenomas syndrome: The role of MUTYH mutation and the polyps' number in clinical management and colorectal cancer risk., [RefSeq, PubMed]; Pan-Cancer Interrogation of MUTYH Variants Reveals Biallelic Inactivation and Defective Base Excision Repair Across a Spectrum of Solid Tumors., [RefSeq, PubMed]; This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DPZ4;Q15830;Q9UBP2;Q9UBS7;Q9UIF4;Q9UIF5;Q9UIF6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0032357 oxidized purine DNA binding;GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0019104 DNA N-glycosylase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006284 base-excision repair;GO:0045007 depurination;GO:0006298 mismatch repair;GO:0060546 negative regulation of necroptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "Q9UIF7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P19105-1",
        "uniprot_id": "ML12A_HUMAN",
        "mass": 19794.0,
        "length": 171,
        "protein_name": "Myosin regulatory light chain 12A",
        "gene_name": "MYL12A",
        "organism": "Human",
        "refseq_name": "myosin regulatory light chain 12A isoform 1",
        "refseq_ac": "NP_001289976",
        "gene_names_uniprotkb": "MYL12A; MLCB; MRLC3; RLC",
        "gene_names_refseq": "HEL-S-24; MLC-2B; MLCB; MRCL3; MRLC3; MYL12A; MYL2B",
        "protein_names_uniprotkb": "Myosin regulatory light chain 12A; Epididymis secretory protein Li 24; HEL-S-24; MLC-2B; Myosin RLC; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulatory light chain MRLC3",
        "protein_names_refseq": "epididymis secretory protein Li 24; myosin RLC; myosin regulatory light chain 12A isoform 1; myosin regulatory light chain 12A; myosin regulatory light chain 2, nonsarcomeric; myosin regulatory light chain 3; myosin regulatory light chain MRLC3; myosin, light chain 12A, regulatory, non-sarcomeric; myosin, light polypeptide, regulatory, non-sarcomeric (20kD)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10627);  (R-HSA-3928664);  (R-HSA-445355)",
        "pathway_count": 3,
        "publication_count": 107,
        "publication_id_list": "10047984;10991994;11237011;11242081;11457814;11485996;11532985;11557983;11889009;11942626;11983165;12048254;12185584;12676796;12695502;14506282;14627618;15377279;156362;15800193;17055381;17310244;17924679;18974361;1930128;19380584;19415658;19915143;20068231;21457715;2216787;22421042;22778174;23328677;23646949;23834404;24714562;24872348;2526655;25502872;25576301;26362469;26992070;27397612;2764880;27679490;27862975;28649982;28741090;28904123;29351928;29557506;30315122;30429286;30484775;30779550;30784271;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31937595;32157095;32161166;32502341;32897882;32938616;32983136;33091337;33141586;33214551;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34357683;34433824;34509645;34561969;34932366;35008409;35051231;35251023;35318648;35561310;35580925;36010968;36284347;3780718;37938771;8858389;9481611;9598563;9600334;9855623",
        "class_list": "",
        "function": "Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity)., [UniProtKB]; This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53X45",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0032036 myosin heavy chain binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0016460 myosin II complex",
        "go_biological_process": "GO:0070527 platelet aggregation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.0,
        "record_id": "P19105-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A0U1RRE5-1",
        "uniprot_id": "NBDY_HUMAN",
        "mass": 7025.0,
        "length": 68,
        "protein_name": "Negative regulator of P-body association",
        "gene_name": "NBDY",
        "organism": "Human",
        "refseq_name": "negative regulator of P-body association",
        "refseq_ac": "NP_001335058",
        "gene_names_uniprotkb": "NBDY; LINC01420",
        "gene_names_refseq": "LINC01420; NBDY; NoBody",
        "protein_names_uniprotkb": "Negative regulator of P-body association; P-body dissociating protein; Protein NoBody",
        "protein_names_refseq": "P-body dissociating protein; long intergenic non-protein coding RNA 1420; negative regulator of P-body association; non-annotated P-body dissociating polypeptide; protein NoBody",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:550643)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;26728094;27918561;29242379;30429286;30833945;31562613;31848261;31998317;32039714;32157095;32488085;32897882;32983136;33123756;33298915;33592498;34171305;35051231",
        "class_list": "",
        "function": "LINC01420 RNA structure and influence on cell physiology Publication Status: Online-Only, [RefSeq, PubMed]; Long Non-coding RNA LINC01420 Contributes to Pancreatic Cancer Progression Through Targeting KRAS Proto-oncogene., [RefSeq, PubMed]; Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process., [UniProtKB, PubMed]; Results implicate NoBody as a novel component of the mRNA decapping complex and demonstrate potential functionality of a newly discovered microprotein, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 19,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000932 P-body",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "A0A0U1RRE5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UPV9-1",
        "uniprot_id": "TRAK1_HUMAN",
        "mass": 106040.0,
        "length": 953,
        "protein_name": "Trafficking kinesin-binding protein 1",
        "gene_name": "TRAK1",
        "organism": "Human",
        "refseq_name": "trafficking kinesin-binding protein 1 isoform 1",
        "refseq_ac": "NP_001036111",
        "gene_names_uniprotkb": "TRAK1; KIAA1042; OIP106",
        "gene_names_refseq": "DEE68; EIEE68; MILT1; OIP106; TRAK1",
        "protein_names_uniprotkb": "Trafficking kinesin-binding protein 1; 106 kDa O-GlcNAc transferase-interacting protein; Protein Milton",
        "protein_names_refseq": "106 kDa O-GlcNAc transferase-interacting protein; O-linked N-acetylglucosamine transferase interacting protein 106; OGT(O-Glc-NAc transferase)-interacting protein 106 KDa; milton homolog 1; protein Milton; trafficking kinesin-binding protein 1 isoform 1; trafficking protein, kinesin binding 1",
        "tax_id": 9606,
        "disease": "developmental and epileptic encephalopathy 68 (Disease Ontology:DOID:0112204); neurodegenerative disease (Disease Ontology:DOID:1289); Stiff-Person syndrome (Disease Ontology:DOID:13366)",
        "pathway": " (hsa:22906);  (R-HSA-6802952);  (R-HSA-9013419);  (R-HSA-9013425)",
        "pathway_count": 4,
        "publication_count": 71,
        "publication_id_list": "11237011;12435728;12724313;15630448;15644324;16630562;18669648;18675823;18974108;18986759;19103291;19528298;20526349;21424530;22645359;22745804;23186163;23583981;24135138;24345920;24995978;25204415;25576301;25907612;26992070;27600516;27846572;27920218;28228285;28364549;28446606;28514659;28657654;28832583;28904123;28940097;29242379;29288388;29331515;29393594;29557506;29632711;29694881;29789417;29846532;30111583;30410026;30513825;30620550;31092671;31479585;31844290;32157095;32357974;32387766;32897882;32938750;33119838;33592498;33912179;34019948;34509645;35051231;35580925;36241641;36284347;37399073;37938771;37949220;39302247;40136647",
        "class_list": "",
        "function": "GRIF-1 and OIP106 have roles in protein and/or organelle transport in excitable cells in a manner analogous to glutamate receptor-interacting-protein 1, [RefSeq, PubMed]; Interaction between the mitochondrial adaptor MIRO and the motor adaptor TRAK., [RefSeq, PubMed]; Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Recurrent TRAK1::RAF1 Fusions in pediatric low-grade gliomas., [RefSeq, PubMed]; TRAK1-Mediated Abnormality of Mitochondrial Fission Increases Seizure Susceptibility in Temporal Lobe Epilepsy., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 4,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 14,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 14,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 14,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "risk",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 16,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PDS2;J3KNT7;Q63HR0;Q659B5;Q96B69",
        "ec_number_list": "",
        "go_molecular_function": "GO:0017022 myosin binding;GO:0050811 GABA receptor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006493 protein O-linked glycosylation;GO:0006605 protein targeting;GO:0008333 endosome to lysosome transport;GO:0022008 neurogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 8.7,
        "record_id": "Q9UPV9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6UWV2-1",
        "uniprot_id": "MPZL3_HUMAN",
        "mass": 25989.0,
        "length": 235,
        "protein_name": "Myelin protein zero-like protein 3",
        "gene_name": "MPZL3",
        "organism": "Human",
        "refseq_name": "myelin protein zero-like protein 3 isoform b precursor",
        "refseq_ac": "NP_001273081",
        "gene_names_uniprotkb": "MPZL3; PRO7425",
        "gene_names_refseq": "MPZL3",
        "protein_names_uniprotkb": "Myelin protein zero-like protein 3",
        "protein_names_refseq": "myelin protein zero-like protein 3 isoform b precursor; myelin protein zero-like protein 3",
        "tax_id": 9606,
        "disease": "lung cancer (Disease Ontology:DOID:1324)",
        "pathway": " (hsa:196264)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12975309;15340161;19054061;24190977;29242379;29493099;29786170;31020640;32983136;33592498;34357683;35580925;37074911",
        "class_list": "",
        "function": "Homozygous or compound heterozygous mutations of MPZL3 might be involved in immune-mediated human hereditary disorders with hair loss., [RefSeq, PubMed]; Mediates homophilic cell-cell adhesion., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K025;B4DLD5;B4E2I8",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007155 cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q6UWV2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P11137-1",
        "uniprot_id": "MTAP2_HUMAN",
        "mass": 199526.0,
        "length": 1827,
        "protein_name": "Microtubule-associated protein 2",
        "gene_name": "MAP2",
        "organism": "Human",
        "refseq_name": "microtubule-associated protein 2 isoform 5",
        "refseq_ac": "NP_001034627",
        "gene_names_uniprotkb": "MAP2",
        "gene_names_refseq": "MAP-2; MAP2A; MAP2B; MAP2C; MAP2",
        "protein_names_uniprotkb": "Microtubule-associated protein 2; MAP-2",
        "protein_names_refseq": "microtubule-associated protein 2 isoform 5",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); asphyxia neonatorum (Disease Ontology:DOID:11088); arteriovenous malformation (Disease Ontology:DOID:11294); sciatic neuropathy (Disease Ontology:DOID:11446); Lewy body dementia (Disease Ontology:DOID:12217); Huntington's disease (Disease Ontology:DOID:12858); brain ischemia (Disease Ontology:DOID:2316); temporal lobe epilepsy (Disease Ontology:DOID:3328); cerebral infarction (Disease Ontology:DOID:3526); schizophrenia (Disease Ontology:DOID:5419)",
        "pathway": " (hsa:4133)",
        "pathway_count": 1,
        "publication_count": 52,
        "publication_id_list": "11029056;11237011;15345747;15536091;16959974;17081983;17525332;18212344;18220336;18510355;18707149;19415658;20058876;20166139;21406692;23481700;24275569;2455776;2481044;28218747;28657654;28832583;29393594;29437277;29485866;29557506;29632711;30192525;30524438;31154438;31217245;31844290;31848261;32157095;32983136;33592498;33894126;33912179;33968037;33981976;35051231;35229233;35251023;35580925;35987383;37258650;37286038;37702880;37938771;7525290;8294038;8631898",
        "class_list": "",
        "function": "Differential regulation of MAP2 by phosphorylation events in proline-rich versus C-terminal domains., [RefSeq, PubMed]; Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology. Publication Status: Online-Only, [RefSeq, PubMed]; MAP2 caps tau fibrils and inhibits aggregation., [RefSeq, PubMed]; Predicting Clinical Outcomes 7-10 Years after Severe Traumatic Brain Injury: Exploring the Prognostic Utility of the IMPACT Lab Model and Cerebrospinal Fluid UCH-L1 and MAP-2., [RefSeq, PubMed]; Specific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions., [RefSeq, PubMed]; The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules., [UniProtKB]; This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 63,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 63,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 10,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q17S04;Q8IUX2;Q99975;Q99976",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding;GO:0005198 structural molecule activity;GO:0048156 tau protein binding;GO:0002162 dystroglycan binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0030425 dendrite;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0016358 dendrite development;GO:0031175 neuron projection development;GO:0032880 regulation of protein localization;GO:0031113 regulation of microtubule polymerization;GO:0048813 dendrite morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "P11137-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q7Z406-1",
        "uniprot_id": "MYH14_HUMAN",
        "mass": 227871.0,
        "length": 1995,
        "protein_name": "Myosin-14",
        "gene_name": "MYH14",
        "organism": "Human",
        "refseq_name": "myosin-14 isoform 1",
        "refseq_ac": "NP_001070654",
        "gene_names_uniprotkb": "MYH14; FP17425; KIAA2034",
        "gene_names_refseq": "DFNA4A; DFNA4; FP17425; MHC16; MYH14; MYH17; NMHC II-C; NMHC-II-C; PNMHH; myosin",
        "protein_names_uniprotkb": "Myosin-14; Myosin heavy chain 14; Myosin heavy chain, non-muscle IIc; NMHC II-C; Non-muscle myosin heavy chain IIc",
        "protein_names_refseq": "MYH14 variant protein; myosin heavy chain, non-muscle IIc; myosin, heavy chain 14, non-muscle; myosin, heavy polypeptide 14; myosin-14 isoform 1; myosin-14; non-muscle myosin heavy chain IIc; nonmuscle myosin heavy chain II-C",
        "tax_id": 9606,
        "disease": "MYH-9 related disease (Disease Ontology:DOID:0060651); autosomal dominant nonsyndromic deafness 4A (Disease Ontology:DOID:0110573); sensorineural hearing loss (Disease Ontology:DOID:10003); peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome (MONDO:MONDO:0013711)",
        "pathway": " (hsa:79784);  (R-HSA-3928663);  (R-HSA-416572);  (R-HSA-5625740);  (R-HSA-5625900);  (R-HSA-5627117);  (R-HSA-5627123)",
        "pathway_count": 7,
        "publication_count": 163,
        "publication_id_list": "10047984;10092231;10330186;10470034;10619026;10639334;10652353;10748018;10753910;10769020;10924361;10975528;11018042;11134534;11179879;11237011;11278486;11313932;11331307;11804587;11919279;11942626;12185584;12196628;12198493;12220504;12453877;12730235;12783890;12802051;12909352;14514689;14580336;14594953;15000491;15003508;15004565;15015131;15184667;15210733;15378014;15498874;15791647;15848799;16202622;16204230;16219803;16222661;16431929;16854367;17151359;17301291;18006505;18025083;18160138;18675813;18829550;19240025;19289088;19413330;19513348;19723632;20068231;20444238;21098037;21351730;21406692;21480433;21749319;22293177;23161543;23186163;23444367;23481700;23716662;24128008;24166499;24209856;24275569;24714562;24859002;25418920;25502872;25576301;25645385;25880248;25892735;26038232;26375851;26853435;26992070;27452731;27600516;27862975;28832583;28855257;28904123;29242379;29351928;29493099;29557506;2966156;29786170;29789417;30315122;30397120;30429286;30779550;3079756;31154438;31222486;31530632;31844290;31848261;31998317;32157095;32357974;32387766;32502341;32711451;32897882;32938616;32983136;33592498;33691108;33912179;33968037;33981976;34019948;34051236;34374341;34509645;34561969;34681017;34725712;34932366;35008409;35051231;35154160;35318648;35580925;36010968;36215666;36241641;36284347;38352997;3839510;40914422;41018975;7559638;8107774;8543060;8662509;8702756;9278512;9354661;9535855;9683637;9792683;9870942;9870943;9889122;9988689",
        "class_list": "",
        "function": "A novel MYH14 mutation in a Chinese family with autosomal dominant nonsyndromic hearing loss. Publication Status: Online-Only, [RefSeq, PubMed]; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping., [UniProtKB]; Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of novel MYH14 variants in families with autosomal dominant sensorineural hearing loss., [RefSeq, PubMed]; Mutations in myosin S2 alter cardiac myosin-binding protein-C interaction in hypertrophic cardiomyopathy in a phosphorylation-dependent manner., [RefSeq, PubMed]; Prevalence and Clinical Characteristics of Hearing Loss Caused by MYH14 Variants. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 4,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0I1S2;C3TTN4;Q5CZ75;Q6XYE4;Q76B62;Q8WV23;Q96I22;Q9BT27;Q9BW35;Q9H882",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003774 cytoskeletal motor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005903 brush border;GO:0016020 membrane;GO:0030426 growth cone",
        "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0019228 neuronal action potential;GO:0031032 actomyosin structure organization;GO:0007605 sensory perception of sound;GO:0008360 regulation of cell shape",
        "synthesized_glycan_count": 0,
        "hit_score": 16.8,
        "record_id": "Q7Z406-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BQI3-1",
        "uniprot_id": "E2AK1_HUMAN",
        "mass": 71106.0,
        "length": 630,
        "protein_name": "Eukaryotic translation initiation factor 2-alpha kinase 1",
        "gene_name": "EIF2AK1",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 2-alpha kinase 1 isoform b",
        "refseq_ac": "NP_001127807",
        "gene_names_uniprotkb": "EIF2AK1; HRI; KIAA1369; PRO1362",
        "gene_names_refseq": "EIF2AK1; HCR; HRI; hHRI",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2-alpha kinase 1; 2.7.11.1; HCR; Heme-controlled repressor; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; Heme-regulated inhibitor; Hemin-sensitive initiation factor 2-alpha kinase; hHRI",
        "protein_names_refseq": "eukaryotic translation initiation factor 2-alpha kinase 1 isoform b; heme regulated initiation factor 2 alpha kinase; heme sensitive initiation factor 2a kinase; heme-controlled repressor; heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; heme-regulated repressor; hemin-controlled repressor; hemin-sensitive initiation factor 2-alpha kinase",
        "tax_id": 9606,
        "disease": "leukoencephalopathy, motor delay, spasticity, and dysarthria syndrome (MONDO:MONDO:0030036)",
        "pathway": " (hsa:27102);  (R-HSA-9648895);  (R-HSA-9840373)",
        "pathway_count": 3,
        "publication_count": 121,
        "publication_id_list": "10931946;10982836;11036079;11101152;11163539;11230166;11237011;11241327;12391722;14630918;17081983;17140605;17267404;17344846;17726049;18055463;18452278;18691976;19664994;20071449;20423929;21872626;22424782;22544926;23481700;23876217;24366607;24715725;25418920;25433032;25576301;25880248;25931127;26154972;26375851;26811146;26923599;26992070;27600516;27846572;27862975;27920218;28228285;28501589;28814160;28832583;28834231;28855257;28904123;29242379;29371260;29393594;29493099;29557506;29632046;29786170;29789417;30315122;30429286;30484775;30524438;30779550;30833945;31154438;31217245;31530632;31844290;31848261;31998317;32132706;32132707;32157095;32197074;32265295;32350084;32357974;32387766;32488085;32502341;32892501;32897882;32938616;32983136;33141586;33168630;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34561969;34932366;35051231;35163244;35251023;35318648;35388015;35561310;35580925;35926182;36010968;36215666;36241641;36284347;37327776;37550454;37938771;38297121;38340717;9153226",
        "class_list": "",
        "function": "Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:37550454, PubMed:38340717). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707, PubMed:37327776). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Iron deficiency also triggers activation by full-length DELE1 (PubMed:37327776). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Also acts as an activator of mitophagy in response to mitochondrial damage: catalyzes phosphorylation of eIF-2-alpha (EIF2S1) following activation by S-DELE1, thereby promoting mitochondrial localization of EIF2S1, triggering PRKN-independent mitophagy (PubMed:38340717)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts., [RefSeq, PubMed]; The eIF2alpha kinase HRI in innate immunity, proteostasis, and mitochondrial stress. Review article, [RefSeq, PubMed]; The eIF2alpha kinase HRI triggers the autophagic clearance of cytosolic protein aggregates., [RefSeq, PubMed]; The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2R2;Q549K6;Q8NBW3;Q9HC02;Q9NYE0;Q9P0V6;Q9P1J5;Q9P2H8;Q9UHG4",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;3.6.5.3;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.7.1.150",
        "go_molecular_function": "GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0020037 heme binding;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:1901526 positive regulation of mitophagy;GO:0008285 negative regulation of cell population proliferation;GO:0046777 protein autophosphorylation;GO:0006446 regulation of translational initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "Q9BQI3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6P1K2-1",
        "uniprot_id": "PMF1_HUMAN",
        "mass": 23339.0,
        "length": 205,
        "protein_name": "Polyamine-modulated factor 1",
        "gene_name": "PMF1",
        "organism": "Human",
        "refseq_name": "polyamine-modulated factor 1 isoform 3",
        "refseq_ac": "NP_001186582",
        "gene_names_uniprotkb": "PMF1",
        "gene_names_refseq": "PMF1",
        "protein_names_uniprotkb": "Polyamine-modulated factor 1; PMF-1",
        "protein_names_refseq": "Est1p-like protein B (EST1B); polyamine-modulated factor 1 isoform 3",
        "tax_id": 9606,
        "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); bladder carcinoma (Disease Ontology:DOID:4007)",
        "pathway": " (hsa:100527963);  (hsa:11243);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5663220);  (R-HSA-68877);  (R-HSA-9648025)",
        "pathway_count": 9,
        "publication_count": 133,
        "publication_id_list": "10411507;10419538;10600384;10678165;10958683;11081627;11181178;11237011;11256947;11371342;11509732;11535616;11804586;12006501;12020345;12194817;12429848;12577064;12679384;12732141;12805219;12852857;14730319;15006353;15085137;15339662;15502821;15507212;15723797;15737063;15864301;15866170;15944396;16292343;16439214;16541025;16585270;16622419;16622420;16682347;16890222;16943183;17030981;17112726;17113138;17129783;17196341;17198702;1737036;18001770;18097444;18716626;18923426;19007248;19350017;19691289;19696148;19815554;19965387;20030946;20068231;20101212;20591975;21111234;21148482;21397845;21576392;21868368;21878504;21987589;22094460;22275430;22608513;22790947;22885700;23222643;23301498;23801653;24397554;24914801;25576301;25740311;25789526;25802875;26154972;26811146;26992070;27397612;27846572;27862975;27920218;28832583;28904123;29242379;29393594;29493099;29557506;29786170;30315122;30429286;30779550;31217245;31373491;31409757;31530632;31844290;32157095;32357974;32387766;32502341;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33912179;33936100;33968037;34093574;34171305;34185709;34260926;34561969;35580925;36010968;36241641;37938771;9649308;9649503;9892021",
        "class_list": "",
        "function": "Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Polyamine-modulated factor 1 binds to CSN7., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K0C5;Q5TCJ8;Q5TCJ9;Q5TCK0;Q5TCK1;Q5TCK3;Q69YZ9;Q6PHR4;Q6ZVE6;Q86VJ6;Q8N4T6;Q9UBQ3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0043522 leucine zipper domain binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0006366 transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "Q6P1K2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P08590-1",
        "uniprot_id": "MYL3_HUMAN",
        "mass": 21932.0,
        "length": 195,
        "protein_name": "Myosin light chain 3",
        "gene_name": "MYL3",
        "organism": "Human",
        "refseq_name": "myosin light chain 3 isoform 1",
        "refseq_ac": "NP_000249",
        "gene_names_uniprotkb": "MYL3",
        "gene_names_refseq": "CMH8; MLC-lV/sb; MLC1SB; MLC1V; MYL3; VLC1; VLCl",
        "protein_names_uniprotkb": "Myosin light chain 3; CMLC1; Cardiac myosin light chain 1; MLC-lV/sb; MLC1SB; Myosin light chain 1, slow-twitch muscle B/ventricular isoform; VLCl; Ventricular myosin alkali light chain; Ventricular myosin light chain 1; Ventricular/slow twitch myosin alkali light chain",
        "protein_names_refseq": "CMLC1; cardiac myosin light chain 1; myosin light chain 3 isoform 1; myosin, light chain 3, alkali; myosin, light polypeptide 3, alkali; ventricular myosin alkali light chain; ventricular myosin light chain 1; ventricular, skeletal, slow; ventricular/slow twitch myosin alkali light chain",
        "tax_id": 9606,
        "disease": "hypertrophic cardiomyopathy 8 (Disease Ontology:DOID:0110314); osteoarthritis (Disease Ontology:DOID:8398)",
        "pathway": " (hsa:4634);  (R-HSA-390522)",
        "pathway_count": 2,
        "publication_count": 22,
        "publication_id_list": "10747208;11237011;12021217;12707239;21823217;23110217;23271734;23594557;26443374;2789520;29557506;30605904;33288880;33298915;3357795;3417683;35051231;36509720;3979397;7498159;8254402;8673105",
        "class_list": "",
        "function": "Autosomal recessive cardiomyopathy and sudden cardiac death associated with variants in MYL3., [RefSeq, PubMed]; In Familial Hypertrophic Cardiomyopathy, the MYL3 Arg94His variant was associated with high disease penetrance and substantial interventricular septal hypertrophy, [RefSeq, PubMed]; MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]., [RefSeq]; Properties of Cardiac Myosin with Cardiomyopathic Mutations in Essential Light Chains., [RefSeq, PubMed]; Regulatory light chain of myosin. Does not bind calcium., [UniProtKB, UniProtKB, UniProtKB]; The study revealed a total of 10 variations - 7 in MYL2 and 3 in MYL3, of which 3 are novel variations observed exclusively in cases. MYL2 and MYL3 mutations are rare and the least cause of cardiomyopathies in Indians., [RefSeq, PubMed]; This is the first report of mutations in TPM1, MY L3, and MYL2 associated with primary, non-hypertrophied restrictive cardiomyopathy., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R534;Q9NRS8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003785 actin monomer binding;GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0003774 cytoskeletal motor activity;GO:0032038 myosin II heavy chain binding",
        "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005829 cytosol;GO:0030017 sarcomere;GO:0031674 I band;GO:0031672 A band",
        "go_biological_process": "GO:0006936 muscle contraction;GO:0060048 cardiac muscle contraction;GO:0002026 regulation of the force of heart contraction;GO:0006942 regulation of striated muscle contraction;GO:0007519 skeletal muscle tissue development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "P08590-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P49914-1",
        "uniprot_id": "MTHFS_HUMAN",
        "mass": 23256.0,
        "length": 203,
        "protein_name": "5-formyltetrahydrofolate cyclo-ligase",
        "gene_name": "MTHFS",
        "organism": "Human",
        "refseq_name": "5-formyltetrahydrofolate cyclo-ligase isoform b",
        "refseq_ac": "NP_001186687",
        "gene_names_uniprotkb": "MTHFS",
        "gene_names_refseq": "HsT19268; MTHFS; NEDMEHM",
        "protein_names_uniprotkb": "5-formyltetrahydrofolate cyclo-ligase; 5,10-methenyl-tetrahydrofolate synthetase; 6.3.3.2; MTHFS; Methenyl-THF synthetase",
        "protein_names_refseq": "5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase); 5-formyltetrahydrofolate cyclo-ligase isoform b; methenyl-THF synthetase",
        "tax_id": 9606,
        "disease": "neurodevelopmental disorder with microcephaly, epilepsy, and hypomyelination (MONDO:MONDO:0032705)",
        "pathway": " (hsa:10588);  (R-HSA-196757)",
        "pathway_count": 2,
        "publication_count": 73,
        "publication_id_list": "10091649;10347183;10978331;11237011;12764149;12937168;16171773;17119116;17129779;17308042;17962486;19424049;19738041;19948730;20068231;20498374;21163947;21238436;21876188;2248959;23409799;23934049;24733394;25576301;25892735;2605182;26154972;26992070;27397612;27600516;27846572;27862975;28228285;28832583;28834231;29242379;29393594;29493099;29557506;29632046;30031689;30315122;30429286;3053686;31844290;31848261;32157095;32350084;32387766;32423175;32658475;32938616;33053560;33163492;33298915;33592498;33633747;33912179;34932366;35051231;35251023;35580925;36284347;3801490;3871768;4066659;6323448;7726158;7852378;8218174;8522195;8662720;9753690",
        "class_list": "",
        "function": "Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate., [UniProtKB, PubMed]; Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation, [RefSeq, PubMed]; Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "H3BQ75",
        "ec_number_list": "6.3.3.2",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005542 folic acid binding;GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0006536 glutamate metabolic process;GO:0046655 folic acid metabolic process;GO:0015942 formate metabolic process;GO:0035999 tetrahydrofolate interconversion;GO:0046653 tetrahydrofolate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "P49914-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q02083-1",
        "uniprot_id": "NAAA_HUMAN",
        "mass": 40066.0,
        "length": 359,
        "protein_name": "N-acylethanolamine-hydrolyzing acid amidase",
        "gene_name": "NAAA",
        "organism": "Human",
        "refseq_name": "N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor",
        "refseq_ac": "NP_001035861",
        "gene_names_uniprotkb": "NAAA; ASAHL; PLT",
        "gene_names_refseq": "ASAHL; NAAA; PLT",
        "protein_names_uniprotkb": "N-acylethanolamine-hydrolyzing acid amidase; 3.5.1.23; 3.5.1.60; ASAH-like protein; Acid ceramidase-like protein; Acylsphingosine deacylase NAAA; N-acylsphingosine amidohydrolase-like",
        "protein_names_refseq": "ASAH-like protein; N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor; N-acylethanolamine-hydrolyzing acid amidase; acid ceramidase-like protein; acylsphingosine deacylase NAAA",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27163);  (R-HSA-112310)",
        "pathway_count": 2,
        "publication_count": 51,
        "publication_id_list": "10.1101/2023.09.13.557529;10610717;11237011;1446826;15610181;15655246;17980170;18793752;19159218;22040171;22825852;23481700;24190977;24741114;25892735;26992070;27693242;28218747;28657654;28832583;28904123;29242379;29393594;29437277;29557506;29632046;29632711;29741879;29769354;30301806;30524438;31750736;31844290;32157095;32350084;32387766;32897882;32938616;32983136;33537174;33912179;33968037;34087483;34171305;34357683;35051231;35069601;35251023;35580925;37074911;38253038",
        "class_list": "",
        "function": "Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine (PubMed:15655246, PubMed:17980170, PubMed:18793752, PubMed:22825852, PubMed:30301806). Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine (PubMed:15655246)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Insights Into the Prognostic Value and Immunological Role of NAAA in Pan-Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The level and activity of acid ceramidase in Alzheimer disease (AD) brain may play a role in controlling neuronal apoptosis and may mediate signalling pathways involved in the molecular mechanism of AD., [RefSeq, PubMed]; The results suggest that N-acylethanolamine acid amidase and protein tyrosine kinase 7 may be used as potential tissue biomarkers to avoid overtreatment of non-aggressive prostate cancer, [RefSeq, PubMed]; The rs2276886 SNP was found to be significantly associated with Hashimoto's Thyroiditis susceptibility. However, our findings suggest that this SNP which maps to the chromosomal region 4q21.1 likely effects the NAAA gene (as opposed to the CXCL9 gene), but still contributes to the susceptibility to Hashimoto's Thyroiditis in Han Chinese populations., [RefSeq, PubMed]; Variants a1 and a2 encoded the same full-length NAAA protein., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 4,
        "mined_n_glycosites": 4,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 10,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5KTF2;Q96EY2;Q9BRA8",
        "ec_number_list": "3.5.1.99;3.1.1.-;3.5.1.23;3.5.1.60;3.5.1.-;3.5.1.109",
        "go_molecular_function": "GO:0017064 fatty acid amide hydrolase activity;GO:0017040 N-acylsphingosine amidohydrolase activity;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0047412 N-(long-chain-acyl)ethanolamine deacylase activity;GO:0140297 DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0005764 lysosome;GO:0043202 lysosomal lumen",
        "go_biological_process": "GO:0070291 N-acylethanolamine metabolic process;GO:0006670 sphingosine metabolic process;GO:0006631 fatty acid metabolic process;GO:0016042 lipid catabolic process;GO:0070292 N-acylphosphatidylethanolamine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q02083-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P13995-1",
        "uniprot_id": "MTDC_HUMAN",
        "mass": 37895.0,
        "length": 350,
        "protein_name": "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial",
        "gene_name": "MTHFD2",
        "organism": "Human",
        "refseq_name": "bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform A precursor",
        "refseq_ac": "NP_006627",
        "gene_names_uniprotkb": "MTHFD2; NMDMC",
        "gene_names_refseq": "MTHFD2; NMDMC",
        "protein_names_uniprotkb": "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial",
        "protein_names_refseq": "NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase; bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform A precursor; bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial",
        "tax_id": 9606,
        "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:10797);  (R-HSA-196757)",
        "pathway_count": 2,
        "publication_count": 116,
        "publication_id_list": "10091649;10347183;10978331;11237011;11929585;12937168;15104674;16100107;16171773;17129779;17308042;17962486;19424049;19608861;19948730;20498374;21163947;21238436;21876188;22424782;2248959;22544926;22898188;23409799;23481700;23783831;23934049;24714562;24715725;24733394;25418920;25576301;25645385;2587219;2605182;26154972;26375851;26728094;26768311;26992070;27600516;27846572;27899380;27920218;28063628;28228285;28510447;28832583;28834231;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29769354;29786170;30192525;30315122;30379171;30524438;3053686;31217245;31530632;31844290;32157095;32265295;32357974;32387766;32423175;32488085;32502341;32658475;32897882;32938616;32983136;33053560;33141586;33163492;33298915;33392160;33537174;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34357683;34509645;35051231;35580925;36010968;36215666;36241641;36284347;36601741;37484807;3801490;38287824;38422037;3871768;38723197;4066659;40914422;6323448;7726158;7852378;8218174;8522195;8662720;9753690",
        "class_list": "",
        "function": "Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency., [UniProtKB, PubMed]; Downregulation of MTHFD2 Inhibits Proliferation and Enhances Chemosensitivity in Hepatocellular Carcinoma via PI3K/AKT Pathway., [RefSeq, PubMed]; Implications of MTHFD2 expression in renal cell carcinoma aggressiveness. Publication Status: Online-Only, [RefSeq, PubMed]; MTHFD2-mediated redox homeostasis promotes gastric cancer progression under hypoxic conditions., [RefSeq, PubMed]; SNHG3/hsa-miR-455-5p Axis-mediated High Expression of MTHFD2 Correlates with Tumor Immune Infiltration and Endometrial Carcinoma Progression. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]., [RefSeq]; Upregulation of MTHFD2 is associated with PDL1 activation in bladder cancer via the PI3K/AKT pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 14,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53G90;Q53GV5;Q53S36;Q7Z650",
        "ec_number_list": "6.3.4.3;1.5.1.5;3.5.4.9;1.5.1.15",
        "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0000287 magnesium ion binding;GO:0004477 methenyltetrahydrofolate cyclohydrolase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0046655 folic acid metabolic process;GO:0035999 tetrahydrofolate interconversion;GO:0046653 tetrahydrofolate metabolic process;GO:0015943 formate biosynthetic process;GO:0006730 one-carbon metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.9,
        "record_id": "P13995-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P17568-1",
        "uniprot_id": "NDUB7_HUMAN",
        "mass": 16402.0,
        "length": 137,
        "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7",
        "gene_name": "NDUFB7",
        "organism": "Human",
        "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7",
        "refseq_ac": "NP_004137",
        "gene_names_uniprotkb": "NDUFB7",
        "gene_names_refseq": "B18; CI-B18; MC1DN39; NDUFB7",
        "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; CI-B18; Cell adhesion protein SQM1; Complex I-B18; NADH-ubiquinone oxidoreductase B18 subunit",
        "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; NADH-ubiquinone oxidoreductase B18 subunit; cell adhesion protein SQM1; complex I B18 subunit; complex I-B18",
        "tax_id": 9606,
        "disease": "nuclear type mitochondrial complex I deficiency (Disease Ontology:DOID:0112065); depressive disorder (Disease Ontology:DOID:1596); mitochondrial complex I deficiency, nuclear type 39 (MONDO:MONDO:0859320)",
        "pathway": " (hsa:4713);  (R-HSA-611105);  (R-HSA-6799198)",
        "pathway_count": 3,
        "publication_count": 89,
        "publication_id_list": "10327278;10830904;10931946;11220739;11237011;11695836;12231006;12611891;12837546;1327877;14741580;15250827;16230336;17033964;17936786;186667;19752196;20406883;20552642;20858599;20934997;21310150;21924235;2302251;23150584;23270816;23553477;23564345;23747254;239860;24191001;24366607;25418920;25564869;25576301;25645385;25678554;26154972;26992070;27499296;27626371;27920218;28510447;28832583;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30779550;30833945;31154438;31222486;31530632;31666358;31844290;31866046;32157095;32265295;32320651;32488085;32502341;32938616;32983136;33502047;33592498;33691108;33879611;33882309;33912179;33968037;34171305;34561969;35051231;35333655;35580925;35614220;36241641;36284347;37938771;38151566;38199007;4288886;9571201;9878551",
        "class_list": "",
        "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed, PubMed]; Protein N-myristoylation plays a critical role in the mitochondrial localization of human mitochondrial complex I accessory subunit NDUFB7. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ICN9;Q9UI16",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0045271 respiratory chain complex I",
        "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration",
        "synthesized_glycan_count": 0,
        "hit_score": 9.2,
        "record_id": "P17568-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TF71-1",
        "uniprot_id": "MOT10_HUMAN",
        "mass": 55493.0,
        "length": 515,
        "protein_name": "Monocarboxylate transporter 10",
        "gene_name": "SLC16A10",
        "organism": "Human",
        "refseq_name": "monocarboxylate transporter 10",
        "refseq_ac": "NP_061063",
        "gene_names_uniprotkb": "SLC16A10; MCT10; TAT1",
        "gene_names_refseq": "MCT10; PRO0813; SLC16A10; TAT1",
        "protein_names_uniprotkb": "Monocarboxylate transporter 10; Aromatic amino acid transporter 1; MCT 10; Solute carrier family 16 member 10; T-type amino acid transporter 1",
        "protein_names_refseq": "MCT 10; T-type amino acid transporter 1; aromatic amino acid transporter 1; monocarboxylate transporter 10; solute carrier family 16 (aromatic amino acid transporter), member 10; solute carrier family 16 (monocarboxylic acid transporters), member 10; solute carrier family 16, member 10 (aromatic amino acid transporter)",
        "tax_id": 9606,
        "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)",
        "pathway": " (hsa:117247);  (R-HSA-352230)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "10358010;10391915;10485994;10698697;10823827;10863037;10891391;10903140;10930503;11237011;11243884;11278508;11318953;11342143;11417227;11591158;11827462;12202949;12527723;12809675;12930836;15151999;15659399;15918515;18195088;18337592;19413330;21097500;21406692;24275569;24652292;26992070;28754537;31820424;31844290;32002290;32350084;32502341;33392160;33912179;34357683;35051231;35580925;36010968;37740545;38750066;38960059;7589472;8010975;8101838;8340364;8702519;8910405;9174363;9878049",
        "class_list": "",
        "function": "Association of DIO2 and MCT10 Polymorphisms With Persistent Symptoms in LT4-Treated Patients in the UK Biobank., [RefSeq, PubMed]; MiR-21-5p modulates LPS-induced acute injury in alveolar epithelial cells by targeting SLC16A10. Publication Status: Online-Only, [RefSeq, PubMed]; SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]., [RefSeq]; Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to Inter-Individual Variance of Executive Functions and Personality Traits. Erratum:[Exp Clin Endocrinol Diabetes. 2020 Sep;128(9):e2. doi: 10.1055/a-1102-8862. PMID: 31978935], [RefSeq, PubMed]; Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; The circular RNA circSLC16A10 alleviates diabetic retinopathy by improving mitochondrial function via the miR-761-5p/MFN2 axis., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWY0;Q6ZMG0;Q8WVI5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015196 L-tryptophan transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0015173 aromatic amino acid transmembrane transporter activity;GO:0015349 thyroid hormone transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction",
        "go_biological_process": "GO:0006865 amino acid transport;GO:0015801 aromatic amino acid transport;GO:0070327 thyroid hormone transport",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q8TF71-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P42285-1",
        "uniprot_id": "MTREX_HUMAN",
        "mass": 117805.0,
        "length": 1042,
        "protein_name": "Exosome RNA helicase MTR4",
        "gene_name": "MTREX",
        "organism": "Human",
        "refseq_name": "exosome RNA helicase MTR4",
        "refseq_ac": "NP_056175",
        "gene_names_uniprotkb": "MTREX; DOB1; KIAA0052; MTR4; SKIV2L2",
        "gene_names_refseq": "Dob1; KIAA0052; MTREX; Mtr4; SKIV2L2; fSAP118",
        "protein_names_uniprotkb": "Exosome RNA helicase MTR4; 3.6.4.13; ATP-dependent RNA helicase DOB1; ATP-dependent RNA helicase SKIV2L2; Superkiller viralicidic activity 2-like 2; TRAMP-like complex helicase",
        "protein_names_refseq": "ATP-dependent RNA helicase DOB1; ATP-dependent RNA helicase SKIV2L2; ATP-dependent helicase SKIV2L2; Ski2 like RNA helicase 2; TRAMP-like complex helicase; exosome RNA helicase MTR4; functional spliceosome-associated protein 118; superkiller viralicidic activity 2-like 2",
        "tax_id": 9606,
        "disease": "amyotrophic lateral sclerosis (Disease Ontology:DOID:332)",
        "pathway": " (hsa:23517);  (R-HSA-6791226);  (R-HSA-72163);  (R-HSA-9843970);  (R-HSA-9930044)",
        "pathway_count": 5,
        "publication_count": 259,
        "publication_id_list": "10882114;11014198;11101529;11233976;11237011;11719186;11922599;11991638;12068309;12150911;12176931;12411573;12414731;12429849;12477934;14625303;14713954;16037817;16043514;16263084;16314458;16738141;16782053;16809785;17095540;17174896;17189298;17332742;17353269;17412707;17606899;18065403;18322460;18438418;18593880;19103666;19106111;19165350;19332556;19536130;19564402;19608861;19801658;20038530;20056613;20068231;20423332;20531386;20798176;20805244;20819938;20871592;20980672;21036871;21063389;21097556;21136679;21536652;21705430;2176635;21855801;22022377;22072790;22110043;22190735;22195017;22223895;22365833;22544926;22658674;22817747;22898188;22916032;22959432;22961380;23186163;23222130;23236153;23345524;23439679;23481700;23482395;2388630;24196718;24304693;24424021;24448447;24550520;24714562;24715725;24737827;24914973;25418920;25525153;25555158;25576301;25578728;2558966;25645385;25772364;25802875;25810538;25880248;25892735;25969445;26022416;26154972;26166824;26237581;26375851;26385511;26420826;26456651;26728094;26811146;26929215;26969736;26992070;27377154;27397612;27434818;27459055;27600516;27683217;27732843;27846572;27862975;27871484;27905398;27920218;28062851;28076346;28218747;28228285;28502770;28510447;28514659;28581500;28781166;28832583;28834231;28904123;29107693;29211708;29242379;29298432;29301961;29331515;29360106;29361316;29393594;29437277;29493099;29508533;29557506;29632046;29632711;2963332;29728366;29786170;29844170;29902117;29906447;30315122;30315277;30410026;30429286;30484775;30524438;30538148;30705154;30728453;30765414;30779550;30833945;30842217;30975767;31217245;31222486;31358741;31409651;31530632;31844290;31848261;31937595;31950173;31998317;32119511;32157095;32161166;32179686;32265295;32329775;32357974;32387766;32488085;32494006;32502341;32897882;32938616;32976585;32983136;33009411;33141586;33214551;33243851;33298915;33392160;33446560;33537174;33592498;33633747;33691108;33717175;33767452;33912179;33913806;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34301950;34357683;34405274;34509645;34561969;34822310;34932366;35051231;35318648;35385551;35561310;35580925;36010968;36215666;36241641;36284347;36403484;36929008;3757028;37875486;37938771;38665916;40914422;8566756;8608946;9016565;9242493;9482744;9512519;9524131;9539711;9671485;9701291;9731529",
        "class_list": "",
        "function": "Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension (PubMed:27871484, PubMed:29844170, PubMed:29906447). Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT) (PubMed:21855801, PubMed:27871484, PubMed:29844170). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484, PubMed:29844170). PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand (PubMed:29844170). Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (PubMed:29906447). Plays a role in DNA damage response (PubMed:29902117)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA processing., [RefSeq, PubMed]; RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2M386;Q6MZZ8;Q6P170;Q8N5R0;Q8TAG2",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;3.6.4.13;2.3.2.27;5.2.1.8;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.6.4.10;3.1.3.1;3.9.1.1;4.2.99.18;5.6.1.6;5.6.2.3;2.1.1.-;3.1.13.-;2.7.7.48;2.7.7.6;3.6.4.12;3.4.21.53;5.6.2.5;3.1.-.-;3.6.5.-;7.6.2.1;2.7.11.1;7.2.2.-;3.4.19.12;5.6.2.-;2.7.1.78;2.7.7.-;2.7.7.19;2.3.2.-;3.1.13.1;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;5.6.2.6;3.4.-.-;3.4.22.-;3.1.26.-;2.7.4.3",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome",
        "go_biological_process": "GO:0006974 DNA damage response;GO:0000398 mRNA splicing, via spliceosome;GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA;GO:0006401 RNA catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 26.2,
        "record_id": "P42285-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y6B2-1",
        "uniprot_id": "EID1_HUMAN",
        "mass": 20876.0,
        "length": 187,
        "protein_name": "EP300-interacting inhibitor of differentiation 1",
        "gene_name": "EID1",
        "organism": "Human",
        "refseq_name": "EP300-interacting inhibitor of differentiation 1",
        "refseq_ac": "NP_055150",
        "gene_names_uniprotkb": "EID1; C15orf3; CRI1; PNAS-22; PTD014; RBP21",
        "gene_names_refseq": "C15orf3; CRI1; EID-1; EID1; IRO45620; PNAS-22; PTD014; RBP21",
        "protein_names_uniprotkb": "EP300-interacting inhibitor of differentiation 1; 21 kDa pRb-associated protein; CREBBP/EP300 inhibitory protein 1; E1A-like inhibitor of differentiation 1; EID-1",
        "protein_names_refseq": "21 kDa pRb-associated protein; CREBBP/EP300 inhibitor 1; CREBBP/EP300 inhibitory protein 1; E1A-like inhibitor of differentiation 1; EP300-interacting inhibitor of differentiation 1; NB4 apoptosis related protein; Rb- and p300-binding protein EID-1; retinoblastoma protein-associated protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23741)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "11073989;11073990;11223246;11237011;15837424;22645359;24366607;24714562;26085330;26154972;26631746;26643909;26992070;27846572;27920218;28228285;28832583;28904123;29557506;30779550;31154438;31222486;31530632;31844290;31848261;31998317;32157095;32357974;32387766;32938616;33141586;33298915;33592498;33633747;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34509645;34561969;34932366;35051231;35580925;36010968;36241641;36284347",
        "class_list": "",
        "function": "EID1 can modulate adipose mesenchymal stem cells, inducing a brown/beige lineage., [RefSeq, PubMed]; Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms., [UniProtKB, PubMed, PubMed]; SCF(FBXO21) polyubiquitylates EID1 both in vitro and in vivo and is required for the efficient degradation of EID1 in both cycling and quiescent cells., [RefSeq, PubMed]; The results suggest that EID1 is a bona fide substrate of FBXO21 and that the control of EID1 abundance by SCF(FBXO)(21) might affect the transcriptional repression activity of EID1., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RD11;Q8N7I4;Q9BZT9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0035035 histone acetyltransferase binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q9Y6B2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A7E2Y1-1",
        "uniprot_id": "MYH7B_HUMAN",
        "mass": 225845.0,
        "length": 1983,
        "protein_name": "Myosin-7B",
        "gene_name": "MYH7B",
        "organism": "Human",
        "refseq_name": "myosin-7B",
        "refseq_ac": "NP_065935",
        "gene_names_uniprotkb": "MYH7B; KIAA1512",
        "gene_names_refseq": "MHC14; MYH14; MYH7B; lncMYH7b",
        "protein_names_uniprotkb": "Myosin-7B; Antigen MLAA-21; Myosin cardiac muscle beta chain; Myosin heavy chain 7B, cardiac muscle beta isoform; Slow A MYH14",
        "protein_names_refseq": "U937-associated antigen; antigen MLAA-21; myosin, heavy chain 7B, cardiac muscle, beta; myosin, heavy polypeptide 7B, cardiac muscle, beta; myosin-7B; slow A MYH14",
        "tax_id": 9606,
        "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)",
        "pathway": " (hsa:57644)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "11237011;11919279;15755502;18634034;19913121;19948655;25645385;27666969;29242379;29557506;29786170;30192525;30524438;31844290;32357974;32387766;32488085;32502341;33592498;33895132;33968037;34087483;34171305;35051231;36284347;36334627;36963494",
        "class_list": "",
        "function": "Distinct effects of two hearing loss-associated mutations in the sarcomeric myosin MYH7b., [RefSeq, PubMed]; Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles., [RefSeq, PubMed]; Involved in muscle contraction., [UniProtKB, PubMed]; MYH7b, the ortholog of slow myosin 2 (SM2) of frogs and birds, is detected as mRNA in heart, slow muscles and extraocular muscles. MYH7b protein is detected only in a subset of fibers, corresponding to slow-tonic fibers, in extraocular muscles., [RefSeq, PubMed]; Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; The actin-based motor myosin-7b (Myo7b) promotes the accumulation of intermicrovillar adhesion complex (IMAC components at microvillar tips. Myo7b is highly enriched at the tips of microvilli in both kidney and intestinal brush borders, and loss of Myo7b in differentiating intestinal epithelial cells disrupts intermicrovillar adhesion and, thus, brush border assembly., [RefSeq, PubMed]; The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 16,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A6E1W127;Q5JVW7;Q6NT44;Q6NT57;Q6WG75;Q96I57;Q9NWE2;Q9P216",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0032982 myosin filament;GO:0097512 cardiac myofibril;GO:0016460 myosin II complex",
        "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:0086004 regulation of cardiac muscle cell contraction;GO:1905289 regulation of CAMKK-AMPK signaling cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "A7E2Y1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BYG7-1",
        "uniprot_id": "MSTRO_HUMAN",
        "mass": 29054.0,
        "length": 248,
        "protein_name": "Protein maestro",
        "gene_name": "MRO",
        "organism": "Human",
        "refseq_name": "protein maestro isoform b",
        "refseq_ac": "NP_001120646",
        "gene_names_uniprotkb": "MRO; B29; C18orf3",
        "gene_names_refseq": "B29; C18orf3; MRO",
        "protein_names_uniprotkb": "Protein maestro; Male-specific transcription in the developing reproductive organs; Protein B29",
        "protein_names_refseq": "beside the Ma29 deletion; male-specific transcription in the developing reproductive organs; protein maestro isoform b; protein maestro",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83876)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;11401430;12889070;24715725;26992070;27600516;27862975;28406912;28411811;28834231;29557506;30379171;30429286;31154438;31530632;31848261;32157095;33981976;35580925",
        "class_list": "",
        "function": "Study also shows a punctate nuclear expression pattern and disperse cytoplasmic expression pattern of the MRO protein in human granulosa-cumulus cells and in testicular germ cells, which was later validated by western blotting Publication Status: Online-Only, [RefSeq, PubMed]; The sequence and function of the related mouse gene are described., [RefSeq, PubMed]; This gene is specifically transcribed in males before and after differentiation of testis, and the encoded protein may play an important role in a mammalian sex determination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z2I5;B7Z3B2;E9PAT5;E9PBI3;K7EKJ8;Q8N6K5",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005730 nucleolus",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q9BYG7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UBC5-1",
        "uniprot_id": "MYO1A_HUMAN",
        "mass": 118401.0,
        "length": 1043,
        "protein_name": "Unconventional myosin-Ia",
        "gene_name": "MYO1A",
        "organism": "Human",
        "refseq_name": "unconventional myosin-Ia",
        "refseq_ac": "NP_001242970",
        "gene_names_uniprotkb": "MYO1A; MYHL",
        "gene_names_refseq": "BBMI; DFNA48; DIAR15; MIHC; MYHL; MYO1A",
        "protein_names_uniprotkb": "Unconventional myosin-Ia; BBM-I; BBMI; Brush border myosin I; MIHC; Myosin I heavy chain",
        "protein_names_refseq": "brush border myosin I; myosin I heavy chain; myosin, heavy polypeptide-like (100kD); myosin, heavy polypeptide-like 110kDa; unconventional myosin-Ia",
        "tax_id": 9606,
        "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003); diarrhea 15, congenital (MONDO:MONDO:0976268)",
        "pathway": " (hsa:4640)",
        "pathway_count": 1,
        "publication_count": 35,
        "publication_id_list": "10653589;11237011;12736868;15883161;19413330;24616153;24715725;25080041;26517670;26992070;27759032;27862975;28904123;29557506;29786170;29789417;30315122;31154438;31844290;32161166;32387766;32938616;33298915;33968037;34171305;34185709;34211107;34509645;35051231;35251023;35580925;36284347;38253038;40174224;9858156",
        "class_list": "",
        "function": "Involved in directing the movement of organelles along actin filaments., [UniProtKB, UniProtKB, UniProtKB]; One missense variant, p.R544W, was found in the MYO1A gene, and in silico analysis suggested that this variant has deleterious effects on protein function., [RefSeq, PubMed]; These data do not support a causal relationship of variants in MYO1A to sensorineural hearing loss. We suggest that the genotypic ascertainment method is useful to objectively evaluate gene-phenotype associations., [RefSeq, PubMed]; This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional skeletal muscle myosin-1 (MYH1). Unconventional myosins contain the basic domains characteristic of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with autosomal dominant deafness. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Dec 2011]., [RefSeq]; This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 38,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UQD7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003779 actin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0015629 actin cytoskeleton;GO:0016323 basolateral plasma membrane",
        "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030048 actin filament-based movement;GO:0007605 sensory perception of sound;GO:0051648 vesicle localization",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "Q9UBC5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IYA7-1",
        "uniprot_id": "MKX_HUMAN",
        "mass": 39331.0,
        "length": 352,
        "protein_name": "Homeobox protein Mohawk",
        "gene_name": "MKX",
        "organism": "Human",
        "refseq_name": "homeobox protein Mohawk",
        "refseq_ac": "NP_001229631",
        "gene_names_uniprotkb": "MKX; C10orf48; IRXL1",
        "gene_names_refseq": "C10orf48; IFRX; IRXL1; MKX",
        "protein_names_uniprotkb": "Homeobox protein Mohawk",
        "protein_names_refseq": "Iroquois family related homeodomain protein; homeobox protein Mohawk; iroquois homeobox protein-like 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283078)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;16077953;24715725;25312837;25332192;25576301;27527664;27846572;28834231;29242379;31844290;32938616;33115953;36834493",
        "class_list": "",
        "function": "COBL, MKX and MYOC Are Potential Regulators of Brown Adipose Tissue Development Associated with Obesity-Related Metabolic Dysfunction in Children. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that homeobox protein Mohawk (Mkx) is mainly expressed in the outer annulus fibrosus (OAF) of humans and mice. Publication Status: Online-Only, [RefSeq, PubMed]; In silico characterization of the C10orf48 sequence, [RefSeq, PubMed]; May act as a morphogenetic regulator of cell adhesion., [UniProtKB]; Mohawk is a transcription factor that promotes meniscus cell phenotype and tissue repair and reduces osteoarthritis severity., [RefSeq, PubMed]; The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jun 2011]., [RefSeq]; These data shed light on previously unrecognized roles of Mkx in tendinopathy, tenogenesis, and tendon repair as well as in regulating the TGFbeta pathway., [RefSeq, PubMed]; Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWM5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development;GO:0048468 cell development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q8IYA7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IVH4-1",
        "uniprot_id": "MMAA_HUMAN",
        "mass": 46538.0,
        "length": 418,
        "protein_name": "Methylmalonic aciduria type A protein, mitochondrial",
        "gene_name": "MMAA",
        "organism": "Human",
        "refseq_name": "methylmalonic aciduria type A protein, mitochondrial precursor",
        "refseq_ac": "NP_758454",
        "gene_names_uniprotkb": "MMAA",
        "gene_names_refseq": "MMAA; cblA",
        "protein_names_uniprotkb": "Methylmalonic aciduria type A protein, mitochondrial; 3.6.-.-",
        "protein_names_refseq": "methylmalonic aciduria (cobalamin deficiency) cblA type; methylmalonic aciduria type A protein, mitochondrial precursor; methylmalonic aciduria type A protein, mitochondrial; mutant adenosylcobalamin",
        "tax_id": 9606,
        "disease": "methylmalonic acidemia cblA type (Disease Ontology:DOID:0060742); methylmalonic acidemia (Disease Ontology:DOID:14749)",
        "pathway": " (hsa:166785);  (R-HSA-3359475);  (R-HSA-3359478);  (R-HSA-71032);  (R-HSA-9759218)",
        "pathway_count": 5,
        "publication_count": 62,
        "publication_id_list": "10444342;10484769;10978155;11237011;11350191;11481338;11528502;12375236;12438653;12514191;13752080;13934211;15308131;15523652;15643616;15913339;16023992;16281286;16311595;16451139;1670635;16866376;17477549;17892308;17957493;18251506;18385497;18779575;19243433;19447654;19562805;1970180;1977311;19801555;20657474;20876572;21071249;21138732;21697092;22156578;22832074;23026888;23270877;2567699;25892735;28497574;28943303;29557506;29996803;30282455;31844290;33717175;33797888;33968037;34357683;35051231;36010968;4390543;6765947;7909321;8968737;8990001",
        "class_list": "",
        "function": "A candidate gene for mutations (deletion, insertion, stop-codon, missense)in cblA patient cells was identified as MMAA on chromosome 4q31.1-2. It encodes a predicted protein of 418 AA., [RefSeq, PubMed]; DNA from 37 cblA patients was analyzed for deleterious mutations in the MMAA gene by DNA sequencing of exons and flanking sequences Erratum:[Hum Mutat. 2005 Mar;25(3):317], [RefSeq, PubMed]; GTPase, binds and hydrolyzes GTP (PubMed:20876572, PubMed:21138732, PubMed:28497574, PubMed:28943303). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (PubMed:20876572, PubMed:28497574). Functions as a G protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (PubMed:20876572, PubMed:28497574). Plays a dual role as both a protectase and a reactivase for MMUT (PubMed:21138732, PubMed:28943303). Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) (PubMed:21138732, PubMed:28943303). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP (PubMed:21138732, PubMed:28943303)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Localization of hMMAA and its colocalization with hMCM in human, [RefSeq, PubMed]; The 503delC mutation is prevalent in Japanese patients with methylmalonic acidemia., [RefSeq, PubMed]; The protein encoded by this gene is involved in the translocation of cobalamin into the mitochondrion, where it is used in the final steps of adenosylcobalamin synthesis. Adenosylcobalamin is a coenzyme required for the activity of methylmalonyl-CoA mutase. Defects in this gene are a cause of methylmalonic aciduria. [provided by RefSeq, Jul 2008]., [RefSeq]; The two siblings were associated with the MMAA c.365T>C variant. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KX40;Q495G7",
        "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;5.4.99.2;3.6.1.-;3.6.5.4;2.7.11.1;3.6.-.-;3.6.1.15;3.6.1.6;3.6.1.42",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0140104 molecular carrier activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0009235 cobalamin metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q8IVH4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96FF7-1",
        "uniprot_id": "MISP3_HUMAN",
        "mass": 24028.0,
        "length": 219,
        "protein_name": "Uncharacterized protein MISP3",
        "gene_name": "MISP3",
        "organism": "Human",
        "refseq_name": "uncharacterized protein MISP3 isoform 1",
        "refseq_ac": "NP_001278220",
        "gene_names_uniprotkb": "MISP3",
        "gene_names_refseq": "MISP3",
        "protein_names_uniprotkb": "Uncharacterized protein MISP3; MISP family member 3",
        "protein_names_refseq": "uncharacterized protein MISP3 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:113230)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;36284347;38253038",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q96FF7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6ZSM3-1",
        "uniprot_id": "MOT12_HUMAN",
        "mass": 56498.0,
        "length": 516,
        "protein_name": "Monocarboxylate transporter 12",
        "gene_name": "SLC16A12",
        "organism": "Human",
        "refseq_name": "monocarboxylate transporter 12",
        "refseq_ac": "NP_998771",
        "gene_names_uniprotkb": "SLC16A12; MCT12",
        "gene_names_refseq": "CJMG; CRT2; CTRCT47; MCT12; SLC16A12",
        "protein_names_uniprotkb": "Monocarboxylate transporter 12; CRT2; Creatine transporter 2; MCT 12; Solute carrier family 16 member 12",
        "protein_names_refseq": "creatine transporter 2; monocarboxylate transporter 12; monocarboxylic acid transporter 12",
        "tax_id": 9606,
        "disease": "cataract 47 (Disease Ontology:DOID:0070353)",
        "pathway": " (hsa:387700)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;18304496;20181839;21778275;23578822;26376857;29393594;31784090;32249133;32781157;35051231",
        "class_list": "",
        "function": "Functional characterization of monocarboxylate transporter 12 (SLC16A12/MCT12) as a facilitative creatine transporter., [RefSeq, PubMed]; Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Monocarboxylate transporter 12 as a guanidinoacetate efflux transporter in renal proximal tubular epithelial cells., [RefSeq, PubMed]; SLC16A12 is important for lens and kidney homeostasis; its potential role in age-related cataract is discussed., [RefSeq, PubMed]; Study identified a second creatine transporter monocarboxylate transporter 12 (MCT12), encoded by the cataract and glucosuria associated gene SLC16A12; Rssults show SLC6A8 was predominantly found in brain, heart and muscle, while SLC16A12 was more abundant in kidney and retina. In the lens, the two transcripts were found at comparable levels., [RefSeq, PubMed]; The monocarboxylate transporter SLC16A12 may contribute to age-related cataract. Sequences within the 5'UTR modulate translational efficiency with pathogenic consequences. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid transport. A mutation in this gene has been associated with juvenile cataracts with microcornea and renal glucosuria. [provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PSF9;Q5M9M9;Q5T7J2;Q6ZV76",
        "ec_number_list": "",
        "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005308 creatine transmembrane transporter activity;GO:0015292 uniporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane",
        "go_biological_process": "GO:0046449 creatinine metabolic process;GO:0015881 creatine transmembrane transport;GO:0150104 transport across blood-brain barrier",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q6ZSM3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8N4Q1-1",
        "uniprot_id": "MIA40_HUMAN",
        "mass": 15996.0,
        "length": 142,
        "protein_name": "Mitochondrial intermembrane space import and assembly protein 40",
        "gene_name": "CHCHD4",
        "organism": "Human",
        "refseq_name": "mitochondrial intermembrane space import and assembly protein 40 isoform 1",
        "refseq_ac": "NP_001091972",
        "gene_names_uniprotkb": "CHCHD4; MIA40",
        "gene_names_refseq": "CHCHD4; MIA40; TIMM40",
        "protein_names_uniprotkb": "Mitochondrial intermembrane space import and assembly protein 40; Coiled-coil-helix-coiled-coil-helix domain-containing protein 4",
        "protein_names_refseq": "coiled-coil-helix-coiled-coil-helix domain-containing protein 4; mitochondrial intermembrane space import and assembly protein 40 isoform 1; mitochondrial intermembrane space import and assembly protein 40; translocase of inner mitochondrial membrane 40 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:131474);  (R-HSA-1268020)",
        "pathway_count": 2,
        "publication_count": 47,
        "publication_id_list": "14726512;15254020;15644312;15683237;16185709;16849325;17336303;17510655;18174896;18452278;18678864;18779329;19182799;19409522;19453276;19767391;19962426;20593814;21059946;21750375;22214851;23041349;23186364;23301498;23597483;23676665;23811401;25315652;25576301;26004228;26275620;26387864;26697887;28040730;28649982;28832583;29242379;30885959;31844290;32357974;32938616;34087483;35580925;37365177;38411431;38909850;41109133",
        "class_list": "",
        "function": "After passage across the translocase of the mitochondrial outer membrane Erv1 interacts via disulfide bonds with Mia40., [RefSeq, PubMed]; Analysis of how mitochondrial biogenesis switches the sorting pathway of the intermembrane space receptor Mia40, [RefSeq, PubMed]; CHCHD4 regulates the expression of mitochondrial genes that are essential for tumour cell growth. Review article, [RefSeq, PubMed]; CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008]., [RefSeq]; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (PubMed:26004228). Functions as a chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COA7, COX17, COX19, MICU1 and TIMCC/FAM136A (PubMed:16185709, PubMed:19182799, PubMed:21059946, PubMed:23186364, PubMed:23676665, PubMed:26387864, PubMed:30885959, PubMed:41109133). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS (PubMed:30885959). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946, PubMed:23676665). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; First group to discover the expression of the human CHCHD4 isoforms and first to call the human gene CHCHD4, and to clone and show the expression of its alternatively expressed CHCHD4 isoforms (CHCHD4.1 and CHCHD4.2)., [RefSeq, PubMed]; Impaired AIF-CHCHD4 interaction and mitochondrial calcium overload contribute to auditory neuropathy spectrum disorder in patient-iPSC-derived neurons with AIFM1 variant. Publication Status: Online-Only, [RefSeq, PubMed]; Results demonstrate an indispensable role for hMIA40 for the export of Fe-S clusters from mitochondria., [RefSeq, PubMed]; [The glutathionylation of the human mitochondrial protein MIA40 regulates ROS homeostasis]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3Z9;Q96AI2;Q96MY6",
        "ec_number_list": "",
        "go_molecular_function": "GO:0015035 protein-disulfide reductase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space",
        "go_biological_process": "GO:0045041 protein import into mitochondrial intermembrane space;GO:0033108 mitochondrial respiratory chain complex assembly;GO:0051604 protein maturation;GO:0160203 mitochondrial disulfide relay system",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q8N4Q1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13585-1",
        "uniprot_id": "MTR1L_HUMAN",
        "mass": 67369.0,
        "length": 617,
        "protein_name": "Melatonin-related receptor",
        "gene_name": "GPR50",
        "organism": "Human",
        "refseq_name": "melatonin-related receptor",
        "refseq_ac": "NP_004215",
        "gene_names_uniprotkb": "GPR50",
        "gene_names_refseq": "GPR50; H9; Mel1c",
        "protein_names_uniprotkb": "Melatonin-related receptor; G protein-coupled receptor 50; H9",
        "protein_names_refseq": "melatonin-related receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9248)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "15452587;16436372;16778767;19699797;21858214;27181993;29572483;31173244;31324691;31900622;34171305;35051231;36010968;8647286",
        "class_list": "",
        "function": "G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration (PubMed:19699797). Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways (By similarity). Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalization (PubMed:21858214). Also plays a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration (PubMed:29572483)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; GPR50 is a TbetaRI co-receptor with potential impact on cancer development Publication Status: Online-Only, [RefSeq, PubMed]; GPR50 promoter methylation level was decreased in the male Alzheimer's disease group compared with the male control group., [RefSeq, PubMed]; GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors., [RefSeq, PubMed]; Polymorphisms in GPR50 were compared in bipolar affective disorder (BD), major depressive disorder (MDD), schizophrenia (SCZ) and controls. GPR50(Delta502-505) or a variant is a sex-specific risk factor for susceptibility to BD and SCZ. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Pre-eclampsia (PE) plasma IgG1 anti-Epstein-Barr virus nuclear antigen 1 (EBNA-1) antibody cross-reacts with placental protein G protein-coupled receptor 50 (GPR50)., [RefSeq, PubMed]; Results describe sequence variants in the melatonin-related receptor gene (GPR50) that associate with circulating triglyceride and HDL levels. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]., [RefSeq]; Upon cleavage by CAPN1, functions as a scaffold in the nucleus for interacting partners such as GTF2I to promote FOS promoter activation., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0VGG3;Q3ZAR0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008502 melatonin receptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007267 cell-cell signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q13585-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P48443-1",
        "uniprot_id": "RXRG_HUMAN",
        "mass": 50871.0,
        "length": 463,
        "protein_name": "Retinoic acid receptor RXR-gamma",
        "gene_name": "RXRG",
        "organism": "Human",
        "refseq_name": "retinoic acid receptor RXR-gamma isoform c",
        "refseq_ac": "NP_001243500",
        "gene_names_uniprotkb": "RXRG; NR2B3",
        "gene_names_refseq": "NR2B3; RXR-gamma; RXRC; RXRG; RXRgamma",
        "protein_names_uniprotkb": "Retinoic acid receptor RXR-gamma; Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma",
        "protein_names_refseq": "nuclear receptor subfamily 2 group B member 3; retinoic acid receptor RXR-gamma isoform c; retinoic acid receptor RXR-gamma",
        "tax_id": 9606,
        "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969)",
        "pathway": " (hsa:6258);  (R-HSA-383280);  (R-HSA-5362517)",
        "pathway_count": 3,
        "publication_count": 37,
        "publication_id_list": "10235266;10493790;10542397;11237011;11865025;11909957;15175151;15866176;15896744;16751179;17761950;18542081;19144697;19850744;20042001;20215566;21504868;21998312;22424782;22871568;23991366;24397554;25576301;26992070;28121444;28167758;29485866;30192525;30379171;32157095;32387766;32502341;33141586;34633445;35051231;7704533;9653119",
        "class_list": "",
        "function": "Association between functional genetic variants in retinoid X receptor-alpha/gamma and the risk of gestational diabetes mellitus in a southern Chinese population., [RefSeq, PubMed]; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)., [UniProtKB]; This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NIP1;Q6IBU7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0004879 nuclear receptor activity;GO:0044323 retinoic acid-responsive element binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048384 retinoic acid receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "P48443-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8IX30-1",
        "uniprot_id": "SCUB3_HUMAN",
        "mass": 109282.0,
        "length": 993,
        "protein_name": "Signal peptide, CUB and EGF-like domain-containing protein 3",
        "gene_name": "SCUBE3",
        "organism": "Human",
        "refseq_name": "signal peptide, CUB and EGF-like domain-containing protein 3 isoform 2 precursor",
        "refseq_ac": "NP_001290065",
        "gene_names_uniprotkb": "SCUBE3; CEGF3",
        "gene_names_refseq": "CEGF3; SCUBE3; SSFSC2",
        "protein_names_uniprotkb": "Signal peptide, CUB and EGF-like domain-containing protein 3",
        "protein_names_refseq": "CUB domain and EGF-like repeat containing 3; signal peptide, CUB and EGF-like domain-containing protein 3 isoform 2 precursor; signal peptide, CUB and EGF-like domain-containing protein 3",
        "tax_id": 9606,
        "disease": "short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2 (Disease Ontology:DOID:0112358)",
        "pathway": " (hsa:222663);  (R-HSA-1474228)",
        "pathway_count": 2,
        "publication_count": 64,
        "publication_id_list": "10.1101/2023.09.13.557529;10229672;10386589;10706100;10809722;10986281;11375993;11872628;12727852;12843408;14973287;15234972;15591058;15958533;16133547;1649600;16631740;16825321;1698775;1707285;17332331;17354228;17608959;18434311;18658137;19010778;19571574;19657146;19714641;20142769;21030783;21297635;21441952;21670566;21784848;21864727;22159414;23035980;23420440;23845380;24084593;27846572;29557506;31154438;31844290;32983136;33308444;33968037;34411563;35051231;35088579;36010968;37189178;38430026;38982741;7075587;7547873;8226919;8626565;9065415;9115292;9148753;9461298;9852107",
        "class_list": "",
        "function": "Biochemical study of ZNF76 rs10947540 and SCUBE3 rs1888822 single nucleotide polymorphisms in the Egyptian patients with systemic lupus Erythematosus., [RefSeq, PubMed]; CircSCUBE3 promoted ferroptosis to inhibit lung adenocarcinoma progression. Publication Status: Online-Only, [RefSeq, PubMed]; DEPDC1B Promotes Melanoma Angiogenesis and Metastasis through Sequestration of Ubiquitin Ligase CDC16 to Stabilize Secreted SCUBE3., [RefSeq, PubMed]; Epithelium-derived SCUBE3 promotes polarized odontoblastic differentiation of dental mesenchymal stem cells and pulp regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; In lung cancer cells, SCUBE3 could serve as an endogenous autocrine and paracrine ligand of TGF-beta type II receptor, which could regulate TGF-beta receptor signaling and modulate EMT and cancer progression, [RefSeq, PubMed]; Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development. It acts as a coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors (PubMed:33308444). It is required for ligand-induced recruitment of BMP receptors to lipid rafts (By similarity). Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression., [UniProtKB, PubMed, PubMed, UniProtKB]; May act locally and/or distantly through a proteolytic mechanism, and may play an important role in bone cell biology, [RefSeq, PubMed]; Results show that SCUBE3 knockdown was associated with lower vascular permeability in the tumor and effectively inhibited the metastatic potential of non-small-cell lung carcinoma, [RefSeq, PubMed]; Scube3 facilitates both TGFbeta and Hh signalling within an overall role of facillating inflammatory angiogenesis., [RefSeq, PubMed]; This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 42,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5A3;Q5CZB3;Q86UZ9;Q8NAU9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0070700 BMP receptor binding;GO:0036122 BMP binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0007165 signal transduction;GO:0030513 positive regulation of BMP signaling pathway;GO:0045669 positive regulation of osteoblast differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q8IX30-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8WYR4-1",
        "uniprot_id": "RSPH1_HUMAN",
        "mass": 35124.0,
        "length": 309,
        "protein_name": "Radial spoke head 1 homolog",
        "gene_name": "RSPH1",
        "organism": "Human",
        "refseq_name": "radial spoke head 1 homolog isoform 2",
        "refseq_ac": "NP_001273435",
        "gene_names_uniprotkb": "RSPH1; TSA2; TSGA2",
        "gene_names_refseq": "CT79; RSP44; RSPH10A; RSPH1; TSA2; TSGA2",
        "protein_names_uniprotkb": "Radial spoke head 1 homolog; CT79; Cancer/testis antigen 79; Male meiotic metaphase chromosome-associated acidic protein; Meichroacidin; Testis-specific gene A2 protein",
        "protein_names_refseq": "cancer/testis antigen 79; male meiotic metaphase chromosome-associated acidic protein; meichroacidin; radial spoke head 1 homolog isoform 2; radial spoke head 1 homolog; testes specific gene A2 homolog; testis specific A2 homolog",
        "tax_id": 9606,
        "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); primary ciliary dyskinesia 24 (Disease Ontology:DOID:0110628)",
        "pathway": " (hsa:89765)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "17451891;23993197;25186273;29557506;31772028;31844290;33912179;34008076;34171305;35051231;9578619",
        "class_list": "",
        "function": "Deep phenotyping, including quantitative ciliary beating parameters, and extensive genotyping in primary ciliary dyskinesia., [RefSeq, PubMed]; Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia., [UniProtKB, PubMed]; Radial spoke protein 44 denotes the restricted localization of the protein to the radial spokes of the axonemes of both sperm and cilia., [RefSeq, PubMed]; This gene encodes a male meiotic metaphase chromosome-associated acidic protein. This gene is expressed in tissues with motile cilia or flagella, including the trachea, lungs, airway brushings, and testes. Mutations in this gene result in primary ciliary dyskinesia-24. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]., [RefSeq]; Whole-exome sequencing reveals a combination of extremely rare single-nucleotide polymorphism of DNAH9 and RSPH1 genes in a Japanese fetus with situs viscerum inversus., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MWV0;B2RBN9;Q3MJA1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0001520 outer dense fiber;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005929 cilium",
        "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0003341 cilium movement;GO:0035082 axoneme assembly;GO:0051321 meiotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8WYR4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HBU6-1",
        "uniprot_id": "EKI1_HUMAN",
        "mass": 50968.0,
        "length": 452,
        "protein_name": "Ethanolamine kinase 1",
        "gene_name": "ETNK1",
        "organism": "Human",
        "refseq_name": "ethanolamine kinase 1 isoform B",
        "refseq_ac": "NP_001034570",
        "gene_names_uniprotkb": "ETNK1; EKI1",
        "gene_names_refseq": "EKI 1; EKI1; EKI; ETNK1; Nbla10396",
        "protein_names_uniprotkb": "Ethanolamine kinase 1; 2.7.1.82; EKI 1",
        "protein_names_refseq": "ethanolamine kinase 1 isoform B; putative protein product of Nbla10396",
        "tax_id": 9606,
        "disease": "heart conduction disease (Disease Ontology:DOID:10273); microcephaly (Disease Ontology:DOID:10907); epilepsy (Disease Ontology:DOID:1826)",
        "pathway": " (hsa:55500);  (R-HSA-1483213)",
        "pathway_count": 2,
        "publication_count": 89,
        "publication_id_list": "10.1101/2023.09.13.557529;10191259;10893425;11044454;11237011;11912161;12216837;12221122;12750860;15175005;17132865;17478478;18583706;19913121;19915674;20628086;22241472;24190977;24366607;24397554;24714562;24715725;25343957;25418920;25576301;25880248;25892735;26154972;26375851;26728094;26811146;26992070;27600516;27846572;27862975;27920218;28228285;28514659;28649982;28832583;28904123;29242379;29331515;29393594;29437277;29493099;29557506;29632046;29769354;29786170;30315122;30410026;31217245;31255331;31844290;32157095;32265295;32350084;32357974;32488085;32502341;32897882;32938616;32983136;33141586;33230096;33298915;33392160;33537174;33592498;33717175;33912179;33936100;33968037;33981976;34171305;34185709;34932366;35051231;35154160;35561310;35580925;36010968;36241641;36284347;36583229;37074911;37938771;9083101",
        "class_list": "",
        "function": "DAD-R, SOX5, and EKI1 map within region of chromosome 12p whose duplication is related to reduced apoptosis in human testicular seminomas., [RefSeq, PubMed]; ETNK1 mutation occurs in a wide spectrum of myeloid neoplasms and is not specific for atypical chronic myeloid leukemia., [RefSeq, PubMed]; ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine. Publication Status: Online-Only, [RefSeq, PubMed]; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis., [UniProtKB, PubMed]; MiR-199a-3p regulates the invasion and migration of gastric cancer cells by targeting ETNK1, [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "G5E969",
        "ec_number_list": "2.7.1.32;2.7.1.82",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0004305 ethanolamine kinase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0006646 phosphatidylethanolamine biosynthetic process;GO:0008654 phospholipid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "Q9HBU6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86XE3-1",
        "uniprot_id": "MICU3_HUMAN",
        "mass": 60711.0,
        "length": 530,
        "protein_name": "Calcium uptake protein 3, mitochondrial",
        "gene_name": "MICU3",
        "organism": "Human",
        "refseq_name": "calcium uptake protein 3, mitochondrial isoform 1",
        "refseq_ac": "NP_859074",
        "gene_names_uniprotkb": "MICU3; EFHA2",
        "gene_names_refseq": "EFHA2; MICU3; hMICU3",
        "protein_names_uniprotkb": "Calcium uptake protein 3, mitochondrial; EF-hand domain-containing family member A2; hMICU3",
        "protein_names_refseq": "EF hand domain family A2; EF-hand domain family, member A2; EF-hand domain-containing family member A2; calcium uptake protein 3, mitochondrial isoform 1; calcium uptake protein 3, mitochondrial; mitochondrial calcium uptake family member 3; mitochondrial uptake family, member 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:286097);  (R-HSA-8949215);  (R-HSA-8949664)",
        "pathway_count": 3,
        "publication_count": 38,
        "publication_id_list": "11237011;12438411;15904662;17178908;18628306;19797662;20018762;20693986;21685886;21685888;21720385;23409044;23716663;23755363;23900286;24162235;24231807;24344246;24503055;24560927;24898248;25077561;25171321;25565209;25753332;26976564;27099988;27642048;27669901;27737933;29725115;30699349;31844290;35051231;36010968;38253038;38747181;7399049",
        "class_list": "",
        "function": "MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy., [RefSeq, PubMed]; Multiple crystal structures of MICU2 and MICU3 from Homo sapiens, were determined., [RefSeq, PubMed]; Tissue-specific calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which specifically regulates MCU channel activity in the central nervous system and skeletal muscle (PubMed:29725115). Senses calcium level via its EF-hand domains: compared to MICU1 and MICU2, MICU3 has a higher affinity for calcium (PubMed:29725115). MICU1 and MICU3 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (PubMed:29725115). At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (PubMed:29725115). At higher calcium levels, calcium-binding to MICU1 and MICU3 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU3 heterodimer away from the pore, allowing calcium permeation through the MCU channel (PubMed:29725115). The high calcium affinity of MICU3 lowers the calcium threshold necessary for calcium permeation through the MCU channel (PubMed:29725115). The MICU1-MICU3 heterodimer promotes flexibility of neurotransmission in neuronal cells by enhancing mitochondrial calcium uptake in presynapses (PubMed:29725115). It is also required to increase mitochondrial calcium uptake in skeletal muscle cells, thereby increasing ATP production (By similarity)., [UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IYZ3",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:1990246 uniplex complex",
        "go_biological_process": "GO:0071277 cellular response to calcium ion;GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis;GO:0001956 positive regulation of neurotransmitter secretion;GO:0006851 mitochondrial calcium ion transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q86XE3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8NEV4-1",
        "uniprot_id": "MYO3A_HUMAN",
        "mass": 186208.0,
        "length": 1616,
        "protein_name": "Myosin-IIIa",
        "gene_name": "MYO3A",
        "organism": "Human",
        "refseq_name": "myosin-IIIa isoform 1",
        "refseq_ac": "NP_059129",
        "gene_names_uniprotkb": "MYO3A",
        "gene_names_refseq": "DFNA90; DFNB30; MYO3A",
        "protein_names_uniprotkb": "Myosin-IIIa; 2.7.11.1",
        "protein_names_refseq": "epididymis secretory sperm binding protein; myosin-IIIa isoform 1; myosin-IIIa",
        "tax_id": 9606,
        "disease": "autosomal dominant nonsyndromic deafness 90 (Disease Ontology:DOID:0070607); autosomal recessive nonsyndromic deafness 30 (Disease Ontology:DOID:0110489)",
        "pathway": " (hsa:53904);  (R-HSA-9662360);  (R-HSA-9662361)",
        "pathway_count": 3,
        "publication_count": 31,
        "publication_id_list": "10025409;10821263;10936054;11163272;11237011;12032315;12672820;15302935;17344846;19562805;24366607;25402663;25576301;25645385;25822849;28834231;29557506;29786170;29880844;30078552;31530632;32387766;32519820;33078831;33953343;33981976;34423747;34509645;34788109;35051231;38042485",
        "class_list": "",
        "function": "Actin-dependent motor protein with a protein kinase activity, playing an essential role in hearing (PubMed:12032315, PubMed:29880844, PubMed:34788109). Probably also plays a role in vision. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:29880844, PubMed:34788109)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Class III myosin is an actin-based motor protein having a protein kinase activity, [RefSeq, PubMed]; Deafness mutation in the MYO3A motor domain impairs actin protrusion elongation mechanism., [RefSeq, PubMed]; Frequency and origin of the c.2090T>G p.(Leu697Trp) MYO3A variant associated with autosomal dominant hearing loss., [RefSeq, PubMed]; Molecular insights into MYO3A kinase domain variants explain variability in both severity and progression of DFNB30 hearing impairment., [RefSeq, PubMed]; Mutation in humans causes progressive nonsyndromic hearing loss DFNB30, [RefSeq, PubMed]; The dynamics of actin protrusions can be controlled by tip-localized myosin motors., [RefSeq, PubMed]; The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008]., [RefSeq]; Whole exome sequencing reveals pathogenic variants in MYO3A, MYO15A and COL9A3 and differential frequencies in ancestral alleles in hearing impairment genes among individuals from Cameroon., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4G0X2;Q5VZ28;Q8WX17;Q9NYS8",
        "ec_number_list": "5.6.2.4;3.6.1.-;3.6.4.-;2.7.11.1;3.6.4.13;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.6.4.6;3.6.1.5;2.7.7.7;2.7.7.49;3.1.26.-;3.6.4.10;2.7.11.22;2.7.11.13;2.7.2.3;3.1.3.1;3.9.1.1;2.7.11.23;4.2.99.18;5.6.1.6;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;5.6.2.3;2.3.1.48;3.6.4.12;2.3.1.-;3.4.21.53;5.6.2.5;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;3.1.-.-;2.7.11.31;3.6.5.-;7.6.2.1;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;7.2.2.-;5.6.2.-;2.3.2.-;2.7.11.38;2.7.11.34;3.6.1.15;3.1.4.-;3.6.-.-;3.4.24.-;3.1.13.1;5.6.2.6;3.4.-.-;1.8.-.-;2.7.1.150;2.7.4.3",
        "go_molecular_function": "GO:0003779 actin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0030175 filopodium;GO:0001917 photoreceptor inner segment;GO:0031941 filamentous actin",
        "go_biological_process": "GO:0030832 regulation of actin filament length;GO:0007601 visual perception;GO:0046777 protein autophosphorylation;GO:0007605 sensory perception of sound;GO:0051491 positive regulation of filopodium assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q8NEV4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BUP0-1",
        "uniprot_id": "EFHD1_HUMAN",
        "mass": 26928.0,
        "length": 239,
        "protein_name": "EF-hand domain-containing protein D1",
        "gene_name": "EFHD1",
        "organism": "Human",
        "refseq_name": "EF-hand domain-containing protein D1 isoform 2",
        "refseq_ac": "NP_001230181",
        "gene_names_uniprotkb": "EFHD1; PP3051; SWS2",
        "gene_names_refseq": "EFHD1; MST133; MSTP133; PP3051; SWS2",
        "protein_names_uniprotkb": "EF-hand domain-containing protein D1; EF-hand domain-containing protein 1; Swiprosin-2",
        "protein_names_refseq": "EF-hand domain-containing protein 1; EF-hand domain-containing protein D1 isoform 2; swiprosin-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80303)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "11237011;12270117;15498874;17074750;20068231;20166139;24275569;24861485;26975899;28832583;29557506;29786170;29789417;31154438;31844290;32157095;32387766;32488085;32938616;33298915;33968037;34171305;34509645;35051231;35580925;36747492;37938771",
        "class_list": "",
        "function": "Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (PubMed:26975899). May play a role in neuronal differentiation (By similarity)., [UniProtKB, PubMed, UniProtKB]; Cloning of novel mouse genes associated with neuronal function, including Efhd1., [RefSeq, PubMed]; Detection of methylation of PPP1R3C alone or in combination with EFHD1 in plasma DNA showed high sensitivity and specificity in CRC detection, and may be useful detection method for CRC, especially for early-stage CRCs., [RefSeq, PubMed]; EFHD1 functions as a novel mitochondrial Ca(2+) sensor underlying Ca(2+)-dependent activation of mitoflashes, [RefSeq, PubMed]; EFHD1, a novel mitochondrial regulator of tumor metastasis in clear cell renal cell carcinoma., [RefSeq, PubMed]; This gene encodes a member of the EF-hand super family of calcium binding proteins, which are involved in a variety of cellular processes including mitosis, synaptic transmission, and cytoskeletal rearrangement. The protein encoded by this gene is composed of an N-terminal disordered region, proline-rich elements, two EF-hands, and a C-terminal coiled-coil domain. This protein has been shown to associate with the mitochondrial inner membrane, and in HeLa cells, acts as a novel mitochondrial calcium ion sensor for mitochondrial flash activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RD83;E9PFH3;Q9BTF8;Q9H8I2;Q9HBQ0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:1900069 regulation of cellular hyperosmotic salinity response",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q9BUP0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O00566-1",
        "uniprot_id": "MPP10_HUMAN",
        "mass": 78864.0,
        "length": 681,
        "protein_name": "U3 small nucleolar ribonucleoprotein protein MPP10",
        "gene_name": "MPHOSPH10",
        "organism": "Human",
        "refseq_name": "U3 small nucleolar ribonucleoprotein MPP10",
        "refseq_ac": "NP_005782",
        "gene_names_uniprotkb": "MPHOSPH10; MPP10",
        "gene_names_refseq": "CT90; MPHOSPH10; MPP10P; MPP10; PPP1R106",
        "protein_names_uniprotkb": "U3 small nucleolar ribonucleoprotein protein MPP10; M phase phosphoprotein 10",
        "protein_names_refseq": "U3 small nucleolar ribonucleoprotein MPP10; U3 small nucleolar ribonucleoprotein; m phase phosphoprotein 10; protein phosphatase 1, regulatory subunit 106",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10199);  (R-HSA-6790901);  (R-HSA-6791226)",
        "pathway_count": 3,
        "publication_count": 152,
        "publication_id_list": "10.1101/2023.09.13.557529;10606270;11081632;11237011;11922599;11935223;11978965;12068309;12150911;12417735;12429849;12655004;15199136;16037817;16043514;16381836;16738141;16782898;17081983;17189298;17322306;17353269;17412707;17636026;18065403;18438418;18452278;18669648;18767875;19007248;19033376;19106111;19332556;19463982;19564402;19608861;19651622;19690332;19691289;19801658;20038530;20047967;20056613;20068231;20531386;20798176;20805244;20819938;21036871;21063389;21097556;21406692;22072790;22190735;22195017;22916032;23186163;23391857;23439679;23481700;23482395;2388630;24086612;24275569;24424021;24550520;24714562;24715725;25218447;25411247;25525153;25576301;25645385;25653167;25755297;25851604;25969445;26085946;26154972;26196125;26237581;26728094;26992070;27084949;27397612;27600516;27846572;27862975;27893789;27920218;28063628;28218747;28228285;28649982;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30379171;30410026;30429286;30779550;30833945;31092671;31154438;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32357974;32387766;32502341;32522876;32897882;32938616;32983136;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34509645;34516797;35051231;35580925;36241641;37217939;39894887;40914422;8885239;9211966;9450966;9482744;9512526",
        "class_list": "",
        "function": "Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVJ8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex;GO:0034457 Mpp10 complex",
        "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0006396 RNA processing;GO:0008380 RNA splicing;GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA",
        "synthesized_glycan_count": 0,
        "hit_score": 16.0,
        "record_id": "O00566-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q13506-1",
        "uniprot_id": "NAB1_HUMAN",
        "mass": 54401.0,
        "length": 487,
        "protein_name": "NGFI-A-binding protein 1",
        "gene_name": "NAB1",
        "organism": "Human",
        "refseq_name": "NGFI-A-binding protein 1 isoform 1",
        "refseq_ac": "NP_001308241",
        "gene_names_uniprotkb": "NAB1",
        "gene_names_refseq": "NAB1",
        "protein_names_uniprotkb": "NGFI-A-binding protein 1; EGR-1-binding protein 1; Transcriptional regulatory protein p54",
        "protein_names_refseq": "EGR-1-binding protein 1; EGR1 binding protein 1; NGFI-A-binding protein 1 isoform 1; transcriptional regulatory protein p54",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4664);  (R-HSA-9031628);  (R-HSA-9619665)",
        "pathway_count": 3,
        "publication_count": 255,
        "publication_id_list": "10203854;10220111;10381005;10400691;10611221;10611312;10656257;10727776;10734128;10757804;10826704;10856243;10872467;10882540;10984481;11018254;11027551;11115854;11133365;11157804;11237011;11280768;11331872;11343657;11356866;11394999;11430795;11430802;11567222;11734543;11755530;11782409;11840323;11956230;12056842;12145339;12198163;12399542;12511643;12782656;12799134;1377233;14512514;14522948;14597720;14664827;14969744;15102911;15150276;15161978;15189448;15356632;15449318;15542842;15610069;15620361;15695336;1570299;15733869;15836632;15880109;15907797;16034366;16136673;16187211;16221685;16260776;16287845;16311519;16319321;16339507;16373334;16407550;16484497;16574654;16732277;16923174;1704008;17081983;17088210;17088211;17088212;17325040;17632064;17699610;17853270;17898216;17959798;18056528;18088355;18160048;18212344;1833716;18456662;18524893;1861162;18634568;18803322;19061646;19116276;19143832;19156870;19193899;19194657;19321787;19745155;1975954;19922439;19926875;20068231;20149798;2017159;20213556;2040600;20506119;2052361;20625412;2072895;20832498;21044070;21057636;2109185;21239760;21326363;21411665;21423190;21423191;21486943;21613327;21621608;21653862;21836637;22053691;22065583;22180461;22302795;22333914;2237820;22492709;22764250;22814607;23695165;23747866;23874858;23935197;24060757;24191038;24227709;24366607;24646194;24675079;25218447;25248477;25418920;25569790;25576301;25748042;25755297;25772364;25974668;26018600;26423937;26441514;2676516;26992070;27041596;27128622;27220739;27288457;27600516;27859941;27862975;28063628;28076410;28275114;28286024;28832583;28852375;28904123;29242379;29393594;29493099;29557506;29559111;29632046;29748249;30429286;30833945;31154438;3127059;31530632;31844290;31848261;32157095;32161166;32488085;32938616;33298915;33717175;33912179;33968037;34171305;35254053;35289036;35580925;36241641;3672127;38814199;7551568;7592934;7595538;7608156;7624335;7777577;7823924;7857651;7871435;7876254;7923378;7925941;7935840;8090221;8090222;8138712;8248782;8349731;8413279;8483478;8576248;8583621;8619637;8627307;8647822;8662541;8668170;8756618;8842374;8846918;8918830;9032251;9084409;9343422;9390517;9418898;9418958;9482253;9622090;9705348;9722618;9748295;9770464;9774344;9808461;9822744;9858769",
        "class_list": "",
        "function": "Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2., [UniProtKB]; Data show that the suppressive effect of valproic acid on chondrocytes is not due to reduced expression or recruitment of Egr-1 to the mPGES-1 promoter and involves upregulation of NAB1., [RefSeq, PubMed]; Methylation pattern of the corresponding NGFI-A binding site in the human glucocorticoid receptor exon 1-F specific promoter in post mortem hippocampal tissue., [RefSeq, PubMed]; N6-Methyladenosine modified circ-NAB1 modulates cell cycle and epithelial-mesenchymal transition via CDKN3 in endometrial cancer. Publication Status: Online-Only, [RefSeq, PubMed]; These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75383;O75384;Q6GTU1;Q9UEV1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003712 transcription coregulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 26.0,
        "record_id": "Q13506-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H4I9-1",
        "uniprot_id": "EMRE_HUMAN",
        "mass": 11441.0,
        "length": 107,
        "protein_name": "Essential MCU regulator, mitochondrial",
        "gene_name": "SMDT1",
        "organism": "Human",
        "refseq_name": "essential MCU regulator, mitochondrial precursor",
        "refseq_ac": "NP_201575",
        "gene_names_uniprotkb": "SMDT1; C22orf32; EMRE",
        "gene_names_refseq": "C22orf32; DDDD; EMRE; SMDT1",
        "protein_names_uniprotkb": "Essential MCU regulator, mitochondrial; Single-pass membrane protein with aspartate-rich tail 1, mitochondrial",
        "protein_names_refseq": "UPF0466 protein C22orf32, mitochondrial; essential MCU regulator, mitochondrial precursor; essential MCU regulator, mitochondrial; single-pass membrane protein with aspartate-rich tail 1, mitochondrial",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91689);  (R-HSA-8949215);  (R-HSA-8949664);  (R-HSA-9837999)",
        "pathway_count": 4,
        "publication_count": 99,
        "publication_id_list": "11237011;11923310;12198491;12438411;14623864;15522782;15870080;15904662;16115876;17101804;17178908;17297443;17579211;18477386;18628306;19797662;19841671;20018762;20693986;21685886;21685888;21720385;22262461;22710082;23201127;23409044;23716663;23755363;23900286;23931759;24162235;24231807;24315374;24344246;24503055;24520911;24560927;24898248;25077561;25171321;25565209;25645385;25753332;26489515;26504172;26774479;26811146;26923599;26976564;27099988;27184846;27496948;27642048;27669901;27737933;28218747;28228285;28377575;28396416;28832583;28904123;29242379;29301859;29393594;29437277;29557506;29769354;29932645;30120231;30315122;30379171;30454562;31080062;31097542;31327635;31695197;31844290;32157095;32315830;32357974;32387766;32494073;32762847;32790952;32862359;33141586;33257573;33296646;33968037;34704252;34943861;35051231;35870450;36241641;36629048;37454773;40596516;7399049;7623837",
        "class_list": "",
        "function": "EMRE is essential for in vivo uniporter current and additionally bridges the calcium-sensing role of MICU1 and MICU2 with the calcium-conducting role of MCU. GeneRIF: EMRE (C22orf32) is an integral mitochondrial inner membrane protein and component of the mitochondrial uniporter complex (uniplex).  It is essential for uniporter channel activity. In its absence, the pore does not interact with its regulators MICU1/2., [RefSeq, PubMed]; Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:24231807, PubMed:26774479, PubMed:27099988, PubMed:30454562, PubMed:31080062, PubMed:32315830, PubMed:32494073, PubMed:32762847, PubMed:32790952, PubMed:33296646). Required to bridge the calcium-sensing proteins MICU1 with the calcium-conducting subunit MCU (PubMed:24231807, PubMed:30454562, PubMed:32494073, PubMed:32762847, PubMed:32790952). Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (PubMed:27099988, PubMed:31080062, PubMed:32315830, PubMed:33296646)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex., [RefSeq, PubMed]; Our experiments provide novel details about how MCU/EMRE is regulated by MICU1 and an original approach to investigate MCU/EMRE activation in intact cells. Publication Status: Online-Only, [RefSeq, PubMed]; SMDT1 variants impair EMRE-mediated mitochondrial calcium uptake in patients with muscle involvement., [RefSeq, PubMed]; This gene encodes a core regulatory component of a calcium channel in the mitochondrial inner membrane. [provided by RefSeq, Apr 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5D1;Q8TAB9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0099103 channel activator activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:1990246 uniplex complex",
        "go_biological_process": "GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis;GO:0072732 cellular response to calcium ion starvation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "Q9H4I9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BW60-1",
        "uniprot_id": "ELOV1_HUMAN",
        "mass": 32663.0,
        "length": 279,
        "protein_name": "Very long chain fatty acid elongase 1",
        "gene_name": "ELOVL1",
        "organism": "Human",
        "refseq_name": "very long chain fatty acid elongase 1 isoform 1",
        "refseq_ac": "NP_001243328",
        "gene_names_uniprotkb": "ELOVL1; CGI-88; SSC1",
        "gene_names_refseq": "CGI-88; ELOVL1; IKSHD; Ssc1",
        "protein_names_uniprotkb": "Very long chain fatty acid elongase 1; 2.3.1.199; 3-keto acyl-CoA synthase ELOVL1; ELOVL FA elongase 1; ELOVL fatty acid elongase 1; Elongation of very long chain fatty acids protein 1; Very long chain 3-ketoacyl-CoA synthase 1; Very long chain 3-oxoacyl-CoA synthase 1",
        "protein_names_refseq": "3-keto acyl-CoA synthase ELOVL1; ELOVL FA elongase 1; elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1; elongation of very long chain fatty acids protein 1; very long chain 3-ketoacyl-CoA synthase 1; very long chain 3-oxoacyl-CoA synthase 1; very long chain fatty acid elongase 1 isoform 1; very long chain fatty acid elongase 1",
        "tax_id": 9606,
        "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588); ichthyotic keratoderma, spasticity, hypomyelination, and dysmorphic facial features (MONDO:MONDO:0032798)",
        "pathway": " (hsa:64834);  (R-HSA-2046105);  (R-HSA-2046106);  (R-HSA-75876)",
        "pathway_count": 4,
        "publication_count": 133,
        "publication_id_list": "10548543;10601301;10769175;10899997;10954726;10970790;11500517;11734571;11889465;11988075;12323085;12323090;12371743;12482854;12525535;12562861;12713571;12716664;12897190;12975357;1346092;14636670;15469937;16036915;16371355;16564093;17379924;17681178;17762044;18003621;1834642;18538142;18554506;18728184;19056654;19505953;19575253;19826053;20166112;20937905;21959040;22223895;22424782;22544926;23481700;24715725;25499606;25576301;25645385;25880248;25892735;26154972;26375851;26992070;27452731;27600516;27893789;28218747;28228285;28446606;28510447;28514659;28834231;28904123;29393594;29437277;29493099;29496980;29508533;29557506;29632711;29786170;30315122;30410026;30429286;30484775;30487246;30524438;30779550;31092671;31154438;31217245;31530632;31611695;31844290;31848261;31937595;32157095;32357974;32387766;32488085;32502341;32897882;32938616;33043033;33141586;33298915;33537174;33592498;33691108;33936100;33968037;34019948;34087483;34171305;34185709;34211107;34357683;34509645;34932366;35051231;35154160;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37217939;37938771;38422897;38665916;5411545;7061494;8075637;8096621;8609415;8656081;8832760;9684854;9704073;9732298",
        "class_list": "glycogene",
        "function": "A dominant ELOVL1 mutation causes a neuro-ichthyotic disorder possibly amenable to treatment with PPAR-modulating drugs., [RefSeq, PubMed]; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis (PubMed:20937905). Indirectly inhibits RPE65 via production of VLCFAs., [UniProtKB, PubMed, PubMed, HAMAP, PubMed, PubMed]; ELOV1 promotes very long-chain fatty acid accumulation X-linked adrenoleukodystrophy and is inhibited by CoA esters of bezafibrate and gemfibrozil., [RefSeq, PubMed]; ELOVL1 activity is regulated with the ceramide synthase CERS2, an enzyme essential for C24 sphingolipid synthesis., [RefSeq, PubMed]; He ELOVL1 p.Ser165Phe mutation is a likely cause of ichthyotic keratoderma, spasticity, mild hypomyelination (on MRI) and dysmorphic features (IKSHD)., [RefSeq, PubMed]; The authors identify ELOVL1 (elongation of very-long-chain-fatty acids) as the single elongase catalysing the synthesis of both saturated VLCFA (C26:0) and mono-unsaturated VLCFA (C26:1)., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 257,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DP24;Q53HT2;Q5JUY3;Q8WXU3;Q9NVD9;Q9Y396",
        "ec_number_list": "2.3.1.199",
        "go_molecular_function": "GO:0009922 fatty acid elongase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0036109 alpha-linolenic acid metabolic process;GO:0046513 ceramide biosynthetic process;GO:0061436 establishment of skin barrier;GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.6,
        "record_id": "Q9BW60-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9C0G6-1",
        "uniprot_id": "DYH6_HUMAN",
        "mass": 475983.0,
        "length": 4158,
        "protein_name": "Dynein axonemal heavy chain 6",
        "gene_name": "DNAH6",
        "organism": "Human",
        "refseq_name": "dynein axonemal heavy chain 6",
        "refseq_ac": "NP_001361",
        "gene_names_uniprotkb": "DNAH6; DNAHC6; DNHL1; HL2; KIAA1697",
        "gene_names_refseq": "DNAH6; DNHL1; Dnahc6; HL-2; HL2",
        "protein_names_uniprotkb": "Dynein axonemal heavy chain 6; Axonemal beta dynein heavy chain 6; Ciliary dynein heavy chain 6",
        "protein_names_refseq": "axonemal beta dynein heavy chain 6; ciliary dynein heavy chain 6; dynein axonemal heavy chain 6; dynein heavy chain-like 1; dynein, axonemal, heavy polypeptide 6",
        "tax_id": 9606,
        "disease": "episodic ataxia type 1 (Disease Ontology:DOID:0050989); hypertension (Disease Ontology:DOID:10763); epilepsy (Disease Ontology:DOID:1826)",
        "pathway": " (hsa:1768)",
        "pathway_count": 1,
        "publication_count": 43,
        "publication_id_list": "11175280;23481700;24714562;24715725;26024233;27600516;28206990;28218747;28904123;29242379;29437277;29557506;29786170;30315122;31154438;31530632;31676830;31844290;31848261;32157095;32387766;32488085;32938616;32983136;33091337;33141586;33392160;33633747;33912179;33968037;34211107;34509645;35051231;35318648;36010968;36215666;37424858;37594300;39056782;39894887;40136647;41018975;8812413",
        "class_list": "",
        "function": "A novel frameshift mutation in DNAH6 associated with male infertility and asthenoteratozoospermia. Publication Status: Online-Only, [RefSeq, PubMed]; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity)., [UniProtKB]; Identification of DNAH6 mutations in infertile men with multiple morphological abnormalities of the sperm flagella. Publication Status: Online-Only, [RefSeq, PubMed]; Novel variants in DNAH6 cause male infertility associated with multiple morphological abnormalities of the sperm flagella (MMAF) and ICSI outcomes., [RefSeq, PubMed]; Primary Ciliary Dyskinesia Associated Disease-Causing Variants in CCDC39 and CCDC40 Cause Axonemal Absence of Inner Dynein Arm Heavy Chains DNAH1, DNAH6, and DNAH7. Publication Status: Online-Only, [RefSeq, PubMed]; This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 88,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0PJN9;B5MEE0;B7ZL99;O95493;Q53QZ1;Q53TE5;Q8N1W6;Q92861;Q96BL6;Q9H030;Q9H5E1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding",
        "go_cellular_component": "GO:0005874 microtubule;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0030286 dynein complex;GO:0097729 9+2 motile cilium",
        "go_biological_process": "GO:0060294 cilium movement involved in cell motility",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "Q9C0G6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9GZR5-1",
        "uniprot_id": "ELOV4_HUMAN",
        "mass": 36829.0,
        "length": 314,
        "protein_name": "Very long chain fatty acid elongase 4",
        "gene_name": "ELOVL4",
        "organism": "Human",
        "refseq_name": "very long chain fatty acid elongase 4",
        "refseq_ac": "NP_073563",
        "gene_names_uniprotkb": "ELOVL4",
        "gene_names_refseq": "ADMD; CT118; ELOVL4; ISQMR; SCA34; STGD2; STGD3",
        "protein_names_uniprotkb": "Very long chain fatty acid elongase 4; 2.3.1.199; 3-keto acyl-CoA synthase ELOVL4; ELOVL FA elongase 4; ELOVL fatty acid elongase 4; Elongation of very long chain fatty acids protein 4; Very long chain 3-ketoacyl-CoA synthase 4; Very long chain 3-oxoacyl-CoA synthase 4",
        "protein_names_refseq": "3-keto acyl-CoA synthase ELOVL4; ELOVL FA elongase 4; cancer/testis antigen 118; elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4; elongation of very long chain fatty acids protein 4; very long chain 3-ketoacyl-CoA synthase 4; very long chain 3-oxoacyl-CoA synthase 4; very long chain fatty acid elongase 4",
        "tax_id": 9606,
        "disease": "Stargardt disease (Disease Ontology:DOID:0050817); spinocerebellar ataxia 34 (Disease Ontology:DOID:0050981); Stargardt disease 3 (Disease Ontology:DOID:0061238); corneal dystrophy (Disease Ontology:DOID:2566); diabetic retinopathy (Disease Ontology:DOID:8947); congenital ichthyosis-intellectual disability-spastic quadriplegia syndrome (MONDO:MONDO:0013760)",
        "pathway": " (hsa:6785);  (R-HSA-75876)",
        "pathway_count": 2,
        "publication_count": 46,
        "publication_id_list": "10548543;10954726;11138005;11581213;11726641;11889465;12371743;12482854;12525535;12592226;12975357;15028284;15469937;15557430;16036915;16371355;17379924;17681178;17762044;18003621;18554506;18728184;19505953;19826053;20937905;21959040;22100072;23479632;24566826;25576301;26010696;26992070;27846572;28834231;31844290;32157095;34725421;35051231;36010968;36240223;36464075;36696030;37074911;37592902;5048218;8075637",
        "class_list": "glycogene",
        "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development., [UniProtKB, PubMed, HAMAP, PubMed]; ELOVL4 Mutations That Cause Spinocerebellar Ataxia-34 Differentially Alter Very Long Chain Fatty Acid Biosynthesis., [RefSeq, PubMed]; Expanding the allelic spectrum of ELOVL4-related autosomal recessive neuro-ichthyosis., [RefSeq, PubMed]; Increased VLCFA-lipids and ELOVL4 underlie neurodegeneration in frontotemporal dementia. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. [provided by RefSeq, Jul 2008]., [RefSeq]; Two New Families and a Literature Review of ELOVL4-Associated Spinocerebellar Ataxia Type 34. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 433,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 6,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6B5;Q5TCS2;Q86YJ1;Q9H139",
        "ec_number_list": "2.3.1.199",
        "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity;GO:0009922 fatty acid elongase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0007623 circadian rhythm;GO:0006636 unsaturated fatty acid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q9GZR5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H223-1",
        "uniprot_id": "EHD4_HUMAN",
        "mass": 61175.0,
        "length": 541,
        "protein_name": "EH domain-containing protein 4",
        "gene_name": "EHD4",
        "organism": "Human",
        "refseq_name": "EH domain-containing protein 4",
        "refseq_ac": "NP_644670",
        "gene_names_uniprotkb": "EHD4; FKSG7; HCA10; HCA11; PAST4",
        "gene_names_refseq": "EHD4; PAST4",
        "protein_names_uniprotkb": "EH domain-containing protein 4; Hepatocellular carcinoma-associated protein 10/11; PAST homolog 4",
        "protein_names_refseq": "EH domain-containing protein 4; PAST homolog 4; hepatocellular carcinoma-associated protein 10/11; hepatocellular carcinoma-associated protein HCA11; ortholog of rat pincher",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:30844)",
        "pathway_count": 1,
        "publication_count": 106,
        "publication_id_list": "10673336;12097419;15592455;17081983;17233914;18331452;18669648;19651622;20068231;22424782;23186163;23481700;24714562;24715725;25418920;25469497;25502872;25576301;25645385;25892735;26154972;26375851;26728094;26758079;26811146;26853435;26992070;27397612;27452731;27846572;27862975;27920218;28063628;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30315122;30429286;30524438;30626607;30779550;30833945;31020640;31154438;31217245;31222486;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32800345;32897882;32938616;32966336;32983136;33141586;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33972531;34171305;34185709;34211107;34357683;34405274;34433824;34509645;34932366;35051231;35154160;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37217939;37938771;38665916",
        "class_list": "",
        "function": "A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport (PubMed:17233914, PubMed:18331452). During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; EHD4 is involved in the control of trafficking at the early endosome and regulates exit of cargo toward both the recycling compartment and the late endocytic pathway., [RefSeq, PubMed]; Eps15 Homology Domain Protein 4 (EHD4) is required for Eps15 Homology Domain Protein 1 (EHD1)-mediated endosomal recruitment and fission. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of phostensin in association with Eps 15 homology domain-containing protein 1 (EHD1) and EHD4., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9HAR1;Q9NZN2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding;GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006897 endocytosis;GO:0030100 regulation of endocytosis;GO:0051260 protein homooligomerization;GO:0072659 protein localization to plasma membrane;GO:0071363 cellular response to growth factor stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 10.9,
        "record_id": "Q9H223-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HB03-1",
        "uniprot_id": "ELOV3_HUMAN",
        "mass": 31500.0,
        "length": 270,
        "protein_name": "Very long chain fatty acid elongase 3",
        "gene_name": "ELOVL3",
        "organism": "Human",
        "refseq_name": "very long chain fatty acid elongase 3",
        "refseq_ac": "NP_689523",
        "gene_names_uniprotkb": "ELOVL3; CIG30",
        "gene_names_refseq": "CIG-30; CIG30; ELOVL3",
        "protein_names_uniprotkb": "Very long chain fatty acid elongase 3; 2.3.1.199; 3-keto acyl-CoA synthase ELOVL3; Cold-inducible glycoprotein of 30 kDa; ELOVL FA elongase 3; ELOVL fatty acid elongase 3; Elongation of very long chain fatty acids protein 3; Very long chain 3-ketoacyl-CoA synthase 3; Very long chain 3-oxoacyl-CoA synthase 3",
        "protein_names_refseq": "3-keto acyl-CoA synthase ELOVL3; ELOVL FA elongase 3; cold-inducible glycoprotein of 30 kDa; elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3; elongation of very long chain fatty acids protein 3; very long chain 3-ketoacyl-CoA synthase 3; very long chain 3-oxoacyl-CoA synthase 3; very long chain fatty acid elongase 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83401);  (R-HSA-2046105);  (R-HSA-2046106);  (R-HSA-75876);  (R-HSA-9844594)",
        "pathway_count": 5,
        "publication_count": 55,
        "publication_id_list": "10.1101/2023.09.13.557529;10548543;10601301;10769175;10899997;10954726;10970790;11500517;11734571;11889465;11988075;12323085;12323090;12371743;12482854;12525535;12562861;12713571;12716664;12897190;12975357;1346092;14636670;15469937;16036915;16371355;17379924;17681178;17762044;18003621;1834642;18538142;18554506;18728184;19056654;19505953;19575253;19826053;20937905;21959040;31154107;32157095;35051231;37847682;38422897;5411545;7061494;8075637;8096621;8609415;8656081;8832760;9684854;9704073;9732298",
        "class_list": "glycogene",
        "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, PubMed, HAMAP]; Elongation of very long chain fatty acids-3 (Elovl3) is activated by ZHX2 and is a regulator of cell cycle progression., [RefSeq, PubMed]; Study found that BRG1 expression was up-regulated along with Elvol3 in prostate cancer cells. BRG1 over-expression dose-dependently augmented the induction of the Elovl3 promoter activity, suggesting that regulation of Elovl3 expression by BRG1 occurred at the transcriptional level., [RefSeq, PubMed]; This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 346,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VZL3;Q8N180",
        "ec_number_list": "2.3.1.199",
        "go_molecular_function": "GO:0009922 fatty acid elongase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0036109 alpha-linolenic acid metabolic process;GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0043651 linoleic acid metabolic process;GO:0006636 unsaturated fatty acid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "Q9HB03-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9HCM4-1",
        "uniprot_id": "E41L5_HUMAN",
        "mass": 81856.0,
        "length": 733,
        "protein_name": "Band 4.1-like protein 5",
        "gene_name": "EPB41L5",
        "organism": "Human",
        "refseq_name": "band 4.1-like protein 5 isoform 2",
        "refseq_ac": "NP_001171866",
        "gene_names_uniprotkb": "EPB41L5; KIAA1548",
        "gene_names_refseq": "BE37; EPB41L5; LULU1; LULU; YMO1; YRT",
        "protein_names_uniprotkb": "Band 4.1-like protein 5; Erythrocyte membrane protein band 4.1-like 5",
        "protein_names_refseq": "band 4.1-like protein 5 isoform 2; yurt homolog",
        "tax_id": 9606,
        "disease": "proteinuria (Disease Ontology:DOID:576)",
        "pathway": " (hsa:57669);  (R-HSA-6794361)",
        "pathway_count": 2,
        "publication_count": 53,
        "publication_id_list": "11604393;15540461;16242404;16624946;16846852;17897391;17920587;18669648;18812509;18829961;19690332;20064387;20064388;20519524;21282647;23186163;23481700;24275569;25378172;25576301;27487132;27754741;27871329;28536193;28904123;29557506;30814110;31467225;32157095;32265295;32350084;32357974;32938616;33298915;33691108;33717175;33761352;33912179;33968037;33981976;34087483;34171305;34784520;34932366;35051231;36010968;36596853;7695896;7736595;8576240;9069287;9808458;9927700",
        "class_list": "",
        "function": "A diminution of EPB41L5-dependent signaling programs appears to be a common theme of podocyte disease, and therefore offers unexpected interventional therapeutic strategies to prevent podocyte loss and kidney disease progression., [RefSeq, PubMed]; Arf6 appears to be necessary for both RhoA- and Rac1-driven cancer invasion, [RefSeq, PubMed]; EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission., [RefSeq, PubMed]; EPB41L5 promotes EMT through the ERK/p38 MAPK signaling pathway in esophageal squamous cell carcinoma., [RefSeq, PubMed]; Increased expression of Erythrocyte membrane protein band 4.1-like 5 ( EPB41L5) in gastric cancer associated with poor prognosis and low survival rate.  In experimental models, EPB41L5 mediated TGF induces metastasis., [RefSeq, PubMed]; Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells., [UniProtKB, PubMed]; The Squamous cell carcinoma of the tongue cell line SCC-9, which overexpress Arf6 and AMAP1, also expressed EPB41L5 at high levels to promote invasiveness, whereas the weakly invasive SCC-25 cells did not express EPB41L5 at notable levels. Publication Status: Online-Only, [RefSeq, PubMed]; The importance of a conserved Crumbs-MPP5-EPB41L5 polarity complex in mammals for separation of the apical and basolateral domains through specialized cell-cell junctions, [RefSeq, PubMed]; These results support further investigation into whether EPB41L5 is a biomarker of PNETs with high risk for metastases, [RefSeq, PubMed]; YMO1 suppresses tumor invasion and metastasis by inhibiting RhoC activity., [RefSeq, PubMed]; ZBTB7A suppresses glioblastoma tumorigenesis through the transcriptional repression of EPB41L5., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z5S1;Q8IZ12;Q9H975",
        "ec_number_list": "",
        "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0008092 cytoskeletal protein binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005925 focal adhesion",
        "go_biological_process": "GO:0031032 actomyosin structure organization;GO:0001837 epithelial to mesenchymal transition",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q9HCM4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NZJ5-1",
        "uniprot_id": "E2AK3_HUMAN",
        "mass": 125216.0,
        "length": 1116,
        "protein_name": "Eukaryotic translation initiation factor 2-alpha kinase 3",
        "gene_name": "EIF2AK3",
        "organism": "Human",
        "refseq_name": "eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor",
        "refseq_ac": "NP_004827",
        "gene_names_uniprotkb": "EIF2AK3; PEK; PERK",
        "gene_names_refseq": "EIF2AK3; PEK; PERK; WRS",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2-alpha kinase 3; 2.7.10.2; 2.7.11.1; HsPEK; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; Protein tyrosine kinase EIF2AK3",
        "protein_names_refseq": "PKR-like ER kinase; PRKR-like endoplasmic reticulum kinase; eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor; pancreatic EIF2-alpha kinase; pancreatic eIF-2alpha kinase; protein tyrosine kinase EIF2AK3",
        "tax_id": 9606,
        "disease": "Wolcott-Rallison syndrome (Disease Ontology:DOID:0090060); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:9451);  (R-HSA-381042);  (R-HSA-9700645);  (R-HSA-9725370);  (R-HSA-9755511);  (R-HSA-9909505)",
        "pathway_count": 6,
        "publication_count": 261,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10026192;10216106;10556217;10677345;10702393;10706082;10706887;10932183;10934142;11110708;11237011;11280786;11310834;11504915;11751994;11850821;11907036;11943732;11988758;12086964;12112524;12185581;12198130;12370288;12424201;12700136;12750159;12800156;12920229;12934099;12960215;14517290;14585973;14688281;14764894;14962911;15169778;15208656;15314157;15374880;15588951;15895073;15983046;16153455;16161041;16170336;16286508;16288713;16359182;16813601;16825495;16871283;16939498;16962933;17086210;17185414;17344846;17353907;17416736;17483340;17512459;17625570;17956313;17979524;17998206;18057259;18097461;18238777;18273910;18452557;18593892;18594010;18664456;18691976;18701132;18724359;18923523;18923524;18923525;19456272;19459784;20068231;20378532;20452972;20454865;20495340;21134980;21164297;21213368;21220506;21391649;21406692;21415216;21494621;21502504;21596819;21656749;21734707;21838707;21847362;21948233;21954288;22169477;22249260;22327622;22347464;22424782;22570254;22658521;22789539;22872865;23103912;23104988;23139213;23201355;23239810;23274085;23481700;23584533;23661334;23957430;24011591;24060861;24168455;24190977;24194294;24298019;24445538;24475247;24496003;24508390;24518094;24613930;24675041;24715725;24736082;25040165;25228534;25342631;25393796;25421750;25576301;25793262;25813380;25813404;25892735;25921060;25921531;25925385;26001147;26062823;26101251;26117325;26268696;26301689;26464158;26583321;26939704;26942676;26992070;27145240;27245569;27573755;27846572;27874193;27917829;28220546;28228285;28380357;28404650;28514659;28659337;28741662;28832583;28834231;28855257;28904123;29233872;29242379;29450944;29455642;29526543;29557506;29632711;29769354;29786170;29873274;30131584;30169894;30224801;30315122;30524438;30551605;30610225;30692217;30906465;30922274;31023583;31217245;31366041;31388026;31434731;31455651;31546975;31844290;31848261;31875558;31998317;32157095;32161166;32216767;32284348;32293500;32350084;32387766;32502341;32640524;32672401;32897882;32938616;33009401;33141586;33298915;33384352;33592498;33691108;33717175;33791708;33859744;33912179;33968037;34087483;34123975;34171305;34211107;34405274;34509645;34561969;34932366;35051231;35251023;35561310;35580925;36010968;36215666;36241641;36284347;36793726;37217939;37890465;37937642;37938771;38789639;39116259;39153651;7824924;8633037;9819383",
        "class_list": "",
        "function": "Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV. Publication Status: Online-Only, [RefSeq, PubMed]; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress, such as unfolded protein response (UPR) (PubMed:10026192, PubMed:10677345, PubMed:11907036, PubMed:12086964, PubMed:25925385, PubMed:31023583). Key effector of the integrated stress response (ISR) to unfolded proteins: EIF2AK3/PERK specifically recognizes and binds misfolded proteins, leading to its activation and EIF2S1/eIF-2-alpha phosphorylation (PubMed:10677345, PubMed:27917829, PubMed:31023583). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:10026192, PubMed:10677345, PubMed:31023583, PubMed:33384352). The EIF2AK3/PERK-mediated unfolded protein response increases mitochondrial oxidative phosphorylation by promoting ATF4-mediated expression of COX7A2L/SCAF1, thereby increasing formation of respiratory chain supercomplexes (PubMed:31023583). In contrast to most subcellular compartments, mitochondria are protected from the EIF2AK3/PERK-mediated unfolded protein response due to EIF2AK3/PERK inhibition by ATAD3A at mitochondria-endoplasmic reticulum contact sites (PubMed:39116259). In addition to EIF2S1/eIF-2-alpha, also phosphorylates NFE2L2/NRF2 in response to stress, promoting release of NFE2L2/NRF2 from the BCR(KEAP1) complex, leading to nuclear accumulation and activation of NFE2L2/NRF2 (By similarity). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity). Involved in control of mitochondrial morphology and function (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress., [RefSeq, PubMed]; Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation. Publication Status: Online-Only, [RefSeq, PubMed]; Targeting PERK and GRP78 in colorectal cancer: Genetic insights and novel therapeutic approaches., [RefSeq, PubMed]; The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells., [RefSeq, PubMed]; The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 10,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 39,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 3,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVH1;A0AVH2;B2RCU9;O95846;Q53QY0;Q53SB1",
        "ec_number_list": "2.7.11.1;2.7.11.21;2.7.12.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.10.1;2.7.11.24;2.7.11.25;2.7.10.2;2.7.12.1;2.7.11.39;3.1.26.-;3.1.3.16;2.7.11.22;2.7.11.13;2.7.2.3;2.7.11.23;3.6.4.10;2.7.1.40;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.11;2.3.1.48;2.3.1.-;2.7.1.32;2.7.1.82;3.6.5.3;2.7.10.4;2.7.1.153;2.7.1.137;2.7.11.26;2.7.1.154;6.1.1.16;2.3.2.-;2.7.11.31;2.3.2.27;2.7.11.12;2.7.11.17;2.7.11.8;2.7.11.19;4.1.1.32;3.6.5.-;2.7.11.38;2.7.11.34;3.6.-.-;3.6.1.-;2.3.2.24;2.7.1.150",
        "go_molecular_function": "GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0070417 cellular response to cold;GO:0032055 negative regulation of translation in response to stress;GO:0001525 angiogenesis;GO:0010628 positive regulation of gene expression;GO:0019722 calcium-mediated signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 27.3,
        "record_id": "Q9NZJ5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NZW4-1",
        "uniprot_id": "DSPP_HUMAN",
        "mass": 131151.0,
        "length": 1301,
        "protein_name": "Dentin sialophosphoprotein",
        "gene_name": "DSPP",
        "organism": "Human",
        "refseq_name": "dentin sialophosphoprotein preproprotein",
        "refseq_ac": "NP_055023",
        "gene_names_uniprotkb": "DSPP",
        "gene_names_refseq": "DFNA39; DGI1; DMP3; DPP; DSPP; DSP",
        "protein_names_uniprotkb": "Dentin sialophosphoprotein; DPP; Dentin phosphophoryn",
        "protein_names_refseq": "deafness, autosomal dominant 39; dentin phosphophoryn; dentin phosphoprotein; dentin phosphoryn; dentin sialophosphoprotein preproprotein; dentin sialoprotein",
        "tax_id": 9606,
        "disease": "dentin dysplasia type II (Disease Ontology:DOID:0070707); osteoporosis (Disease Ontology:DOID:11476); Huntington's disease (Disease Ontology:DOID:12858); periventricular leukomalacia (Disease Ontology:DOID:13088); hypothyroidism (Disease Ontology:DOID:1459); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); demyelinating disease (Disease Ontology:DOID:3213); temporal lobe epilepsy (Disease Ontology:DOID:3328); periodontal disease (Disease Ontology:DOID:3388); dentinogenesis imperfecta (Disease Ontology:DOID:4154); schizophrenia (Disease Ontology:DOID:5419); encephalitis (Disease Ontology:DOID:9588); diabetic neuropathy (Disease Ontology:DOID:9743); deafness, autosomal dominant 39, with dentinogenesis imperfecta 1 (MONDO:MONDO:0011571)",
        "pathway": " (hsa:1834);  (R-HSA-3000178)",
        "pathway_count": 2,
        "publication_count": 58,
        "publication_id_list": "10022829;10339611;10673326;10706475;11084047;11175779;11175790;11259413;12225811;12354781;1376317;14715956;14758537;15075323;15296743;1544908;15592686;16293224;16493581;17033625;17588949;17627120;18521831;2059554;21029264;21642437;21789315;22134916;22392858;23509818;2364322;2412224;2420006;2430969;37017752;37084484;38546516;38630328;6193777;6439184;7499434;7527058;7542669;7559467;7685013;7693733;7852349;8002934;8440685;8798654;8943283;9252349;9294172;9341124;9346959;9685393;9879917;9949188",
        "class_list": "",
        "function": "DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals., [UniProtKB]; Identification of DSPP novel variants and phenotype analysis in dentinogenesis dysplasia Shields type II patients., [RefSeq, PubMed]; Isolated dentinogenesis imperfecta: Novel DSPP variants and insights on genetic counselling. Publication Status: Online-Only, [RefSeq, PubMed]; Novel dentin sialophosphoprotein gene frameshift mutations affect dentin mineralization., [RefSeq, PubMed]; The Role of DSPP in Dentine Formation and Hereditary Dentine Defects. Review article, [RefSeq, PubMed]; This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mutations in this gene are associated with dentinogenesis imperfecta and dentin dysplasia. This gene is present in a gene cluster on chromosome 4. Allelic differences due to repeat polymorphisms have been found for this gene. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 12,
        "predicted_n_glycosites": 12,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 277,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 15,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MUI0;O95815",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005518 collagen binding;GO:0005201 extracellular matrix structural constituent",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0097187 dentinogenesis;GO:0031214 biomineral tissue development;GO:0071895 odontoblast differentiation;GO:1901329 regulation of odontoblast differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "Q9NZW4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9P2D7-4",
        "uniprot_id": "DYH1_HUMAN",
        "mass": 487498.0,
        "length": 4265,
        "protein_name": "Dynein axonemal heavy chain 1",
        "gene_name": "DNAH1",
        "organism": "Human",
        "refseq_name": "dynein axonemal heavy chain 1",
        "refseq_ac": "NP_056327",
        "gene_names_uniprotkb": "DNAH1; DHC7; DNAHC1; KIAA1410",
        "gene_names_refseq": "CILD37; DNAH1; DNAHC1; HDHC7; HL-11; HL11; HSRF-1; SPGF18; XLHSRF-1",
        "protein_names_uniprotkb": "Dynein axonemal heavy chain 1; Axonemal beta dynein heavy chain 1; Ciliary dynein heavy chain 1; HSRF-1; Heat shock regulated protein 1; hDHC7",
        "protein_names_refseq": "axonemal beta dynein heavy chain 1; ciliary dynein heavy chain 1; dynein axonemal heavy chain 1; dynein heavy chain 1, axonemal; dynein, axonemal, heavy polypeptide 1; heat shock regulated protein 1; testicular tissue protein Li 60",
        "tax_id": 9606,
        "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); spermatogenic failure 18 (Disease Ontology:DOID:0070165); primary ciliary dyskinesia 37 (Disease Ontology:DOID:0080266); T-cell prolymphocytic leukemia (Disease Ontology:DOID:0081042); graft-versus-host disease (Disease Ontology:DOID:0081267); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); severe combined immunodeficiency 104 (Disease Ontology:DOID:0090014); disease of cellular proliferation (Disease Ontology:DOID:14566); cancer (Disease Ontology:DOID:162); hematologic cancer (Disease Ontology:DOID:2531); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); severe combined immunodeficiency (Disease Ontology:DOID:627); acute megakaryocytic leukemia (Disease Ontology:DOID:8761)",
        "pathway": " (hsa:25981)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "10.1101/2023.09.13.557529;11175280;17924679;18492703;24360805;25927852;27798045;28552195;28832583;29242379;29351928;29449551;37934199;39056782;39894887;41350704;8812413;9256245;9373155",
        "class_list": "",
        "function": "Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805)., [UniProtKB, PubMed, UniProtKB]; Male carriers of the mutations always exhibit asthenozoospermia, whereas female carriers manifest no alterations in either fertility or pulmonary clearance., [RefSeq, PubMed]; Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function. Publication Status: Online-Only, [RefSeq, PubMed]; Primary Ciliary Dyskinesia Associated Disease-Causing Variants in CCDC39 and CCDC40 Cause Axonemal Absence of Inner Dynein Arm Heavy Chains DNAH1, DNAH6, and DNAH7. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella that result in asthenozoospermia and male infertility. Mice with a homozygous knockout of the orthologous gene are viable but have reduced sperm motility and are infertile. [provided by RefSeq, Feb 2017]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 5,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 96,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 15,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0I1R6;O00436;O15435;O95491;Q6ZU48;Q86YK7;Q8TEJ4;Q92863;Q9H8E6;Q9UFW6;Q9Y4Z7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0003777 microtubule motor activity;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding",
        "go_cellular_component": "GO:0005874 microtubule;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0030286 dynein complex;GO:0005858 axonemal dynein complex",
        "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007288 sperm axoneme assembly;GO:0036159 inner dynein arm assembly;GO:0060285 cilium-dependent cell motility",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q9P2D7-4",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UNE0-1",
        "uniprot_id": "EDAR_HUMAN",
        "mass": 48582.0,
        "length": 448,
        "protein_name": "Tumor necrosis factor receptor superfamily member EDAR",
        "gene_name": "EDAR",
        "organism": "Human",
        "refseq_name": "tumor necrosis factor receptor superfamily member EDAR precursor",
        "refseq_ac": "NP_071731",
        "gene_names_uniprotkb": "EDAR; DL",
        "gene_names_refseq": "DL; ECTD10A; ECTD10B; ED1R; ED3; ED5; EDA-A1R; EDA1R; EDA3; EDAR; HRM1",
        "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member EDAR; Anhidrotic ectodysplasin receptor 1; Downless homolog; EDA-A1 receptor; Ectodermal dysplasia receptor; Ectodysplasin-A receptor",
        "protein_names_refseq": "EDA-A1 receptor; anhidrotic ectodysplasin receptor 1; downless homolog; downless, mouse, homolog of; ectodermal dysplasia receptor; ectodysplasin 1, anhidrotic receptor; ectodysplasin A1 receptor; hypohidrotic ectodermal dysplasia; tumor necrosis factor receptor superfamily member EDAR precursor; tumor necrosis factor receptor superfamily member EDAR",
        "tax_id": 9606,
        "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Korean hemorrhagic fever (Disease Ontology:DOID:0050200); inflammatory bowel disease (Disease Ontology:DOID:0050589); COVID-19 (Disease Ontology:DOID:0080600); type 1 diabetes mellitus 10 (Disease Ontology:DOID:0110749); ectodermal dysplasia 10A (Disease Ontology:DOID:0111663); ectodermal dysplasia 10B (Disease Ontology:DOID:0111665); immunodeficiency 41 (Disease Ontology:DOID:0111968); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); Sjogren's syndrome (Disease Ontology:DOID:12894); hypohidrotic ectodermal dysplasia (Disease Ontology:DOID:14793); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); lymphopenia (Disease Ontology:DOID:614); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:10913);  (R-HSA-5669034)",
        "pathway_count": 2,
        "publication_count": 54,
        "publication_id_list": "10.1074/mcp.M114.046862;10074428;10359578;10398604;10431241;10484778;10597252;10615125;11035039;11039935;11571266;11882293;11911831;12189164;12949498;14656435;14729942;15340161;15356117;15373768;15470070;16029325;16435307;16501042;1655907;17632511;18065779;18231121;18561327;18571443;18606301;19438931;20032458;20222921;20307208;20510730;20979233;21300286;22197273;22664871;22801960;24070496;25813380;27657131;34087483;34618839;34916592;36258277;36470092;37739945;7913952;8120384;8871664;9878548",
        "class_list": "",
        "function": "A novel EDAR variant identified in non-syndromic tooth agenesis: Insights from molecular dynamics., [RefSeq, PubMed]; Association of EDARV370A with breast density and metabolic syndrome in Latinos. Publication Status: Online-Only, [RefSeq, PubMed]; Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-kappaB signaling in keratinocyte. Publication Status: Online-Only, [RefSeq, PubMed]; Different degree of loss-of-function among four missense mutations in the EDAR gene responsible for autosomal recessive hypohidrotic ectodermal dysplasia may be associated with the phenotypic severity., [RefSeq, PubMed]; Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia., [RefSeq, PubMed]; Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death., [UniProtKB]; This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 16,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9H2;B4DLC5;D3DX74;E9PC98;Q52LL5;Q9UND9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045177 apical part of cell",
        "go_biological_process": "GO:0030154 cell differentiation;GO:0046330 positive regulation of JNK cascade;GO:0006915 apoptotic process;GO:0008544 epidermis development;GO:0043123 positive regulation of canonical NF-kappaB signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q9UNE0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NCE7-1",
        "uniprot_id": "MP3B2_HUMAN",
        "mass": 14628.0,
        "length": 125,
        "protein_name": "Microtubule-associated protein 1 light chain 3 beta 2",
        "gene_name": "MAP1LC3B2",
        "organism": "Human",
        "refseq_name": "microtubule-associated protein 1 light chain 3 beta 2",
        "refseq_ac": "NP_001078950",
        "gene_names_uniprotkb": "MAP1LC3B2",
        "gene_names_refseq": "ATG8G; MAP1LC3B2",
        "protein_names_uniprotkb": "Microtubule-associated protein 1 light chain 3 beta 2; MAP1A/MAP1B LC3 B-like; MAP1A/MAP1B light chain 3 B-like; Microtubule-associated proteins 1A/1B light chain 3 beta 2; Microtubule-associated proteins 1A/1B light chain 3B-like",
        "protein_names_refseq": "MAP1A/MAP1B LC3 B-like; MAP1A/MAP1B light chain 3 B-like; Microtubule-associated proteins 1A/1B light chain 3B-like protein; microtubule-associated protein 1 light chain 3 beta 2; microtubule-associated proteins 1A/1B light chain 3 beta 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:643246)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "29493099;30661429;31844290;32350084;32357974",
        "class_list": "",
        "function": "Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008017 microtubule binding;GO:0031625 ubiquitin protein ligase binding;GO:0008429 phosphatidylethanolamine binding",
        "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005874 microtubule;GO:0012505 endomembrane system;GO:0031410 cytoplasmic vesicle",
        "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0000423 mitophagy;GO:0006995 cellular response to nitrogen starvation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A6NCE7-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A8MV57-1",
        "uniprot_id": "MPTX_HUMAN",
        "mass": 15138.0,
        "length": 137,
        "protein_name": "Putative mucosal pentraxin homolog",
        "gene_name": "MPTX1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "MPTX1; MPTX",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative mucosal pentraxin homolog",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "18850182;33592498",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0046872 metal ion binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "A8MV57-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60487-1",
        "uniprot_id": "MPZL2_HUMAN",
        "mass": 24484.0,
        "length": 215,
        "protein_name": "Myelin protein zero-like protein 2",
        "gene_name": "MPZL2",
        "organism": "Human",
        "refseq_name": "myelin protein zero-like protein 2 precursor",
        "refseq_ac": "NP_005788",
        "gene_names_uniprotkb": "MPZL2; EVA1; EVA; PRO1192",
        "gene_names_refseq": "DFNB111; EVA1; EVA; MPZL2",
        "protein_names_uniprotkb": "Myelin protein zero-like protein 2; Epithelial V-like antigen 1",
        "protein_names_refseq": "epithelial V-like antigen 1; myelin protein zero-like protein 2 precursor; myelin protein zero-like protein 2",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness 111 (Disease Ontology:DOID:0111640)",
        "pathway": " (hsa:10205)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "10.1101/2023.09.13.557529;12975309;19159218;21440040;23090970;24190977;26677976;29331515;29741879;29961571;29982980;30379171;30429286;30779550;31848261;32157095;33234333;35249471;35580925;36241641;36284347;37074911;37390746;38197511;38254107;9585423",
        "class_list": "",
        "function": "A homozygous MPZL2 deletion is associated with non syndromic hearing loss in a moroccan family., [RefSeq, PubMed]; EVA is expressed in human choroid plexus epithelial cells and CD4 T lymphocytes and regulates CD4+ T lymphocyte adhesion to human choroid plexus epithelial cells in vitro. These data suggest a novel mechanism to regulate CNS immune surveillance., [RefSeq, PubMed]; Findings highlight Eva1 as a novel regulator of GIC function and also provide new mechanistic insight into the role of noncanonical NF-kappaB activation in GIC., [RefSeq, PubMed]; MPZL2 variant analysis with whole exome sequencing in a cohort of Chinese hearing loss patients., [RefSeq, PubMed]; MPZL2-a common autosomal recessive deafness gene related to moderate sensorineural hearing loss in the Chinese population. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates homophilic cell-cell adhesion., [UniProtKB]; Recurrent missense variant identified in two unrelated families with MPZL2-related hearing loss, expanding the variant spectrum associated with DFNB111., [RefSeq, PubMed]; Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 34,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2R1",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009653 anatomical structure morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "O60487-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P12872-1",
        "uniprot_id": "MOTI_HUMAN",
        "mass": 12920.0,
        "length": 115,
        "protein_name": "Promotilin",
        "gene_name": "MLN",
        "organism": "Human",
        "refseq_name": "promotilin isoform 2 preproprotein",
        "refseq_ac": "NP_001035198",
        "gene_names_uniprotkb": "MLN",
        "gene_names_refseq": "MLN",
        "protein_names_uniprotkb": "Promotilin",
        "protein_names_refseq": "prepromotilin; promotilin isoform 2 preproprotein; promotilin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4295);  (R-HSA-375276);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 128,
        "publication_id_list": "10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10899166;11015615;11322507;11385580;11457843;11562423;11683476;11742120;11753430;11773063;12120503;12427552;12495026;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15340161;15539556;1567413;15947423;15951850;16182515;16268778;16339447;1655761;16754659;16923326;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18515384;18577758;18936096;1905813;23446738;23690594;24906252;2574660;2649896;2737284;27496565;27706119;2841328;28566304;2914635;3086311;3202875;3366244;3525564;36284347;36436612;3666144;36888769;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8440682;8463333;8503909;8615752;8664309;8666380;8702752;873923;8823230;9171878;9305846;9521323;9530155;9593744;9607765;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "Hemodialysis improves upper GI symptoms and gastric slow waves in CKD patients. An increase in ghrelin and a decrease in GLP-1 might be involved in the HD-induced improvement in gastric slow waves., [RefSeq, PubMed]; Physiological functions and potential clinical applications of motilin. Review article, [RefSeq, PubMed]; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle., [UniProtKB]; Serotonin, ghrelin, and motilin gene/receptor/transporter polymorphisms in childhood functional constipation. Publication Status: Online-Only, [RefSeq, PubMed]; Serum motilin levels and motilin gene polymorphisms in children with functional constipation., [RefSeq, PubMed]; This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZLR7;E9PDN2;J3KN51;Q2M1L2;Q5T975;Q6NSY7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005179 hormone activity;GO:0031788 motilin receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 12.9,
        "record_id": "P12872-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P20585-1",
        "uniprot_id": "MSH3_HUMAN",
        "mass": 127412.0,
        "length": 1137,
        "protein_name": "DNA mismatch repair protein Msh3",
        "gene_name": "MSH3",
        "organism": "Human",
        "refseq_name": "DNA mismatch repair protein Msh3",
        "refseq_ac": "NP_002430",
        "gene_names_uniprotkb": "MSH3; DUC1; DUG",
        "gene_names_refseq": "DUP; FAP4; MRP1; MSH3",
        "protein_names_uniprotkb": "DNA mismatch repair protein Msh3; DUP; Divergent upstream protein; MRP1; Mismatch repair protein 1; hMSH3",
        "protein_names_refseq": "DNA mismatch repair protein Msh3; divergent upstream protein; epididymis secretory sperm binding protein; hMSH3; mismatch repair protein 1",
        "tax_id": 9606,
        "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); familial adenomatous polyposis 4 (Disease Ontology:DOID:0080412); endometrial cancer (Disease Ontology:DOID:1380); endometrial carcinoma (Disease Ontology:DOID:2871); lung non-small cell carcinoma (Disease Ontology:DOID:3908)",
        "pathway": " (hsa:4437);  (R-HSA-5358606);  (R-HSA-5632927);  (R-HSA-5632928)",
        "pathway_count": 4,
        "publication_count": 101,
        "publication_id_list": "10473346;10944853;11237011;11274057;11427529;11884592;14676842;16143102;16188885;16873062;17426132;19228687;19781088;20068231;20154325;20160730;20571119;20970388;21406692;21496642;22118461;22179786;23186163;23481700;23840062;24366607;25505266;25576301;25892735;26154972;26300262;26768311;26811146;26992070;2722860;27476653;27600516;27846572;28063628;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29769354;29786170;30315122;30429286;30833945;31154438;31844290;31848261;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32938616;33298915;33392160;33592498;33691108;33717175;33912179;33968037;34087483;34171305;34185709;34509645;35051231;35580925;36010968;36215666;36284347;37140056;37402566;37888748;37938771;38281411;39003369;7713503;8128251;8261515;8505312;8782829;8805365;8851770;8942985;9294177;9430682;9469823;9677427",
        "class_list": "",
        "function": "Assessing the impact of MSH3 and MSH6 polymorphisms on lung cancer risk in North Indian patients undergoing platinum chemotherapy through molecular dynamics simulation. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; High-throughput sequencing and in-silico analysis confirm pathogenicity of novel MSH3 variants in African American colorectal cancer., [RefSeq, PubMed]; MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1., [RefSeq, PubMed]; MSH3: a confirmed predisposing gene for adenomatous polyposis. Publication Status: Online-Only, [RefSeq, PubMed]; Novel insights into the ecDNA formation mechanism involving MSH3 in methotrexate-resistant human colorectal cancer cells., [RefSeq, PubMed]; The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 63,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L480;A1L482;A6NMM6;Q6PJT5;Q86UQ6;Q92867",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0003690 double-stranded DNA binding;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016020 membrane;GO:0032302 MutSbeta complex",
        "go_biological_process": "GO:0006312 mitotic recombination;GO:0006281 DNA repair;GO:0006298 mismatch repair;GO:0045910 negative regulation of DNA recombination;GO:0043570 maintenance of DNA repeat elements",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "P20585-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P22897-1",
        "uniprot_id": "MRC1_HUMAN",
        "mass": 166012.0,
        "length": 1456,
        "protein_name": "Macrophage mannose receptor 1",
        "gene_name": "MRC1",
        "organism": "Human",
        "refseq_name": "macrophage mannose receptor 1 precursor",
        "refseq_ac": "NP_002429",
        "gene_names_uniprotkb": "MRC1; CLEC13DL; CLEC13D; MRC1L1",
        "gene_names_refseq": "CD206; CLEC13DL; CLEC13D; MMR; MRC1L1; MRC1; bA541I19.1; hMR",
        "protein_names_uniprotkb": "Macrophage mannose receptor 1; C-type lectin domain family 13 member D-like; C-type lectin domain family 13 member D; Human mannose receptor; MMR; Macrophage mannose receptor 1-like protein 1; hMR",
        "protein_names_refseq": "C-type lectin domain family 13 member D; human mannose receptor; macrophage mannose receptor 1 precursor; macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1-like 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4360);  (R-HSA-1236978);  (R-HSA-9637628);  (R-HSA-9918485)",
        "pathway_count": 4,
        "publication_count": 72,
        "publication_id_list": "10779515;11337487;12061891;12682107;1294118;15098107;15164054;15489334;15507651;15592474;15838506;16818754;1730714;17486091;18249105;18266465;18510355;18780401;19317650;19683778;20028659;20035344;2258707;23084921;23090970;23658209;2373685;24074594;24190977;24275569;25356553;25359607;26056282;26166760;26212330;26468529;27452731;27832191;29225077;29242379;29391424;29557506;29610346;29742433;30429286;30459171;31491467;31720911;32125861;32157095;32162841;32690608;32983136;33043033;33091337;33192174;33545173;33912179;34171305;34185709;34267749;34486997;35051231;35580925;3611070;36183584;36376784;37041007;37074911;38078733;38884861;9931503",
        "class_list": "glycogene",
        "function": "(Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens., [UniProtKB]; (Microbial infection) Acts as a receptor for Dengue virus envelope protein E., [UniProtKB, PubMed]; (Microbial infection) Interacts with Hepatitis B virus envelope protein., [UniProtKB, PubMed]; CD163 and CD206 expression define distinct macrophage subsets involved in active ANCA-associated glomerulonephritis., [RefSeq, PubMed]; CD206[+]CD68[+] mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis. Publication Status: Online-Only, [RefSeq, PubMed]; Detailed role of SR-A1 and SR-E3 in tumor biology, progression, and therapy. Review article, [RefSeq, PubMed]; Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains., [UniProtKB]; Soluble CD206 levels correlate with disease deterioration and predict prognosis of anti-MDA5 antibody-positive dermatomyositis related interstitial lung disease., [RefSeq, PubMed]; The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]., [RefSeq]; Transcriptional regulation of the HIV-1 inhibitory factor human mannose receptor 1 by the myeloid-specific transcription factor PU.1., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1523,
        "reported_interactions": 0,
        "missing_score": 831,
        "biomarker_type": "",
        "glycan_count": 47,
        "disease_count": 0,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5PKW3;Q5VSJ2;Q5VSK2",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0001618 virus receptor activity;GO:0005537 D-mannose binding;GO:0038024 cargo receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0006898 receptor-mediated endocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 13.0,
        "record_id": "P22897-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5T089-1",
        "uniprot_id": "MORN1_HUMAN",
        "mass": 53850.0,
        "length": 497,
        "protein_name": "MORN repeat-containing protein 1",
        "gene_name": "MORN1",
        "organism": "Human",
        "refseq_name": "MORN repeat-containing protein 1 isoform 2",
        "refseq_ac": "NP_001287989",
        "gene_names_uniprotkb": "MORN1",
        "gene_names_refseq": "MORN1",
        "protein_names_uniprotkb": "MORN repeat-containing protein 1",
        "protein_names_refseq": "MORN repeat-containing protein 1 isoform 2; MORN repeat-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79906)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "11237011;23481700;25576301;25645385;25892735;26992070;27600516;28228285;28832583;28834231;28855257;29393594;29557506;29632046;29769354;30315122;30484775;31844290;32265295;32357974;33592498;34185709;36215666;36241641;39894887",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NKZ6;Q8WW30;Q9H852",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q5T089-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TAP9-1",
        "uniprot_id": "MPLKI_HUMAN",
        "mass": 19147.0,
        "length": 179,
        "protein_name": "M-phase-specific PLK1-interacting protein",
        "gene_name": "MPLKIP",
        "organism": "Human",
        "refseq_name": "M-phase-specific PLK1-interacting protein",
        "refseq_ac": "NP_619646",
        "gene_names_uniprotkb": "MPLKIP; C7orf11; TTDN1",
        "gene_names_refseq": "ABHS; C7orf11; MPLKIP; ORF20; TTD4",
        "protein_names_uniprotkb": "M-phase-specific PLK1-interacting protein; TTD non-photosensitive 1 protein",
        "protein_names_refseq": "M-phase-specific PLK1-interacting protein; Russell-Silver syndrome region; TTD non-photosensitive 1 protein",
        "tax_id": 9606,
        "disease": "nonphotosensitive trichothiodystrophy 4 (Disease Ontology:DOID:0050528)",
        "pathway": " (hsa:136647)",
        "pathway_count": 1,
        "publication_count": 52,
        "publication_id_list": "11829489;15645389;16959974;16964243;16977596;17081983;17310276;18669648;18691976;19651622;19664994;20068231;23186163;23555621;24129315;25290684;25418920;25880248;25892735;26518168;26992070;28832583;28834231;29242379;29393594;29557506;29769354;29786170;29789417;30410026;30429286;31154438;31844290;32157095;32265295;32357974;32387766;32488085;33043633;33392160;33691108;33729667;33912179;33968037;34932366;35051231;35318648;35561310;35580925;37507019;37800682;37938771",
        "class_list": "",
        "function": "A novel MPLKIP-variant in three Finnish patients with non-photosensitive trichothiodystrophy type 4., [RefSeq, PubMed]; A novel mutation in the C7orf11 gene causes nonphotosensitive trichothiodystrophy in a multiplex highly consanguineous kindred, [RefSeq, PubMed]; Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain., [RefSeq, PubMed]; Given the absence of cutaneous photosensitivity in the patients with C7orf11 mutations, together with the protein's nuclear localization, C7orf11 may be involved in transcription but not DNA repair., [RefSeq, PubMed]; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis., [UniProtKB, PubMed]; Reported mutations in Trichothiodystrophy do not affect TTDN1 response to ultraviolet (UV) light or the steady state level of the repair/transcription factor IIH (TFIIH), which is central to the onset of the photosensitive form of TTD., [RefSeq, PubMed]; TTDN1 is phosphorylated in mitosis, and this is required for its interaction with polo-like kinase 1., [RefSeq, PubMed]; The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]., [RefSeq]; There is a distinct phenotype relationship in trichothiodystrophy caused by TTDN1 mutations., [RefSeq, PubMed]; Trichothiodystrophy type 4 in an Indian family., [RefSeq, PubMed]; Trichothiodystrophy-associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 18,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030496 midbody",
        "go_biological_process": "GO:0051301 cell division",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q8TAP9-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q8TE76-1",
        "uniprot_id": "MORC4_HUMAN",
        "mass": 106348.0,
        "length": 937,
        "protein_name": "MORC family CW-type zinc finger protein 4",
        "gene_name": "MORC4",
        "organism": "Human",
        "refseq_name": "MORC family CW-type zinc finger protein 4 isoform b",
        "refseq_ac": "NP_001078823",
        "gene_names_uniprotkb": "MORC4; ZCW4; ZCWCC2",
        "gene_names_refseq": "MORC4; ZCW4; ZCWCC2; dJ75H8.2",
        "protein_names_uniprotkb": "MORC family CW-type zinc finger protein 4; Zinc finger CW-type coiled-coil domain protein 2; Zinc finger CW-type domain protein 4",
        "protein_names_refseq": "MORC family CW-type zinc finger protein 4 isoform b; MORC family CW-type zinc finger protein 4; zinc finger CW-type coiled-coil domain protein 2; zinc finger CW-type domain protein 4; zinc finger, CW type with coiled-coil domain 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79710)",
        "pathway_count": 1,
        "publication_count": 47,
        "publication_id_list": "11237011;17608765;26827181;26933034;26992070;27397612;27600516;27846572;28218747;28228285;28834231;28913878;29242379;29437277;29493099;29557506;29632711;29786170;29789417;29930882;30320920;30410026;30429286;30779550;30833945;31154438;31844290;31848261;32157095;32161166;32387766;32488085;32938616;33537174;33592498;33968037;33981976;34087483;34171305;34405274;35051231;35494241;35580925;36284347;36932196;37938771;39302247",
        "class_list": "",
        "function": "Genetic variation in MORC4, CD14, and TLR4 may affect the outcome of allogeneic stem cell transplantation. Publication Status: Online-Only, [RefSeq, PubMed]; Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034)., [UniProtKB, PubMed]; In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]., [RefSeq]; MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo., [RefSeq, PubMed]; SNP in the MORC4-rs 12837024 is associated with Chronic pancreatitis., [RefSeq, PubMed]; These results identified MORC4 as differentially expressed in breast cancer cells and tissues and its downregulation by miR-193b-3p, as well as its roles in regulating the growth of breast cancer cells via regulation of apoptosis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1YR23;A1YR24;H7BXF1;Q5JUK7;Q96MZ2;Q9HAI7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0140002 histone H3K4me3 reader activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q8TE76-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96LB1-1",
        "uniprot_id": "MRGX2_HUMAN",
        "mass": 37099.0,
        "length": 330,
        "protein_name": "Mas-related G protein-coupled receptor member X2",
        "gene_name": "MRGPRX2",
        "organism": "Human",
        "refseq_name": "mas-related G-protein coupled receptor member X2",
        "refseq_ac": "NP_001290544",
        "gene_names_uniprotkb": "MRGPRX2; MRGX2",
        "gene_names_refseq": "MGRG3; MRGPRX2; MRGX2",
        "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member X2",
        "protein_names_refseq": "G protein-coupled receptor MRGX2; MAS-related GPR, member X2; Mas-related G protein-coupled receptor G3; mas-related G-protein coupled receptor member X2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:117194)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11551509;12044878;12915402;15823563;15862286;16161007;18636314;21441599;22069323;23698749;24583173;24930830;25517090;28288109;30686732;34789874;34789875;38279626;38334612;39725036;41167449",
        "class_list": "",
        "function": "Beyond Allergies-Updates on The Role of Mas-Related G-Protein-Coupled Receptor X2 in Chronic Urticaria and Atopic Dermatitis. Publication Status: Online-Only, [RefSeq, PubMed]; CXCL17 induces activation of human mast cells via MRGPRX2., [RefSeq, PubMed]; Cortistatin-14 shown to be a high affinity ligand for G protein coupled receptor MrgX2 which is expressed in dorsal root ganglion, [RefSeq, PubMed]; MRGX2 amino acid substitutions may alter the interactions between MRGX2 protein and its ligand, thus, potentially led to adaptive changes of the pain-perception-related nervous system during human evolution., [RefSeq, PubMed]; Mas, MrgD, and MRG mediated Ang IV-stimulated AA release that was highest for Mas. While Ang III activated Mas and MrgX2, Ang II stimulated AA release via Mas and MRG., [RefSeq, PubMed]; Mast cell-specific G protein-coupled receptor for basic secretagogues, which regulates mast cell degranulation and itch-related hypersensitivity reactions (PubMed:22069323, PubMed:25517090, PubMed:28288109, PubMed:34789874, PubMed:34789875). A secretagogue is an agent that promotes the secretion of hormones, neurohormones, chemical neurotransmitters or other compounds synthesized and secreted by cells (PubMed:25517090). Basic secretagogues comprise a set of cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:28288109, PubMed:34789874, PubMed:34789875). MRGPRX2 is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i) coupling mediates inhibition of adenylate cyclase activity (PubMed:28288109, PubMed:34789874, PubMed:34789875). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium (By similarity). In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for substance P, a basic secretagogue neuropeptide released from the terminals of specific sensory nerves, initiating a signaling that mediates neurogenic inflammation and pain (PubMed:30686732, PubMed:34789875). Neurogenic inflammation includes mast cell activation, recruitment of immune cells and release of inflammatory mediators, such as cytokines and chemokines (By similarity). The inflammatory response can then activate or sensitize nociceptors, promoting pain (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, complanadine A and CXCL17 (PubMed:12915402, PubMed:15823563, PubMed:21441599, PubMed:22069323, PubMed:23698749, PubMed:24930830, PubMed:34789874, PubMed:34789875). Also acts as a receptor for opioids, such as (-)- and (+)-morphine, hydrocodone, sinomenine, dextromethorphan, dynorphin A, dynorphin B, and alpha- and beta-neoendorphin, promoting mast cell degranulation (PubMed:28288109)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5B0C7;Q4QXW4;Q4QXW7;Q4QXX0;Q4QXX2;Q4QXX3;Q4QXX4;Q4QXX6;Q4QXX7;W8W3L5",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:1990595 mast cell secretagogue receptor activity;GO:0042923 neuropeptide binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0016477 cell migration;GO:0070098 chemokine-mediated signaling pathway;GO:0019233 sensory perception of pain",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q96LB1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96LB2-1",
        "uniprot_id": "MRGX1_HUMAN",
        "mass": 36250.0,
        "length": 322,
        "protein_name": "Mas-related G protein-coupled receptor member X1",
        "gene_name": "MRGPRX1",
        "organism": "Human",
        "refseq_name": "mas-related G-protein coupled receptor member X1",
        "refseq_ac": "NP_671732",
        "gene_names_uniprotkb": "MRGPRX1; MRGX1; SNSR3; SNSR4",
        "gene_names_refseq": "GPCR; MGRG2; MRGPRX1; MRGX1; SNSR4",
        "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member X1; Sensory neuron-specific G protein-coupled receptor 3/4",
        "protein_names_refseq": "G protein-coupled receptor MRGX1; G protein-coupled receptor SNSR3; MAS-related GPR, member X1; Mas-related G protein-coupled receptor G2; mas-related G-protein coupled receptor member X1; sensory neuron-specific G-protein coupled receptor 3/4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:259249)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;11551509;11850634;12044878;20004959;23074220;25209672;25505266;26582731;28223516;28768771;30243794;31498617;33358893;35051231;36302898;37347749;37591889;39725036;41167449",
        "class_list": "",
        "function": "Analysis of the functional interactions between MRGPR-X1 and TRPV1, [RefSeq, PubMed]; G protein-coupled receptor specifically expressed in sensory neurons of dorsal root ganglion, and which is involved in itch perception and pain transmission (PubMed:11850634, PubMed:20004959, PubMed:26582731, PubMed:33358893, PubMed:36302898, PubMed:37347749, PubMed:37591889, PubMed:39725036). Specifically activated by a variety of enkephalin (PENK) neuropeptides, such as BAM22 and BAM8-22, which induce itch in a histamine-independent manner (PubMed:11850634, PubMed:36302898, PubMed:37591889, PubMed:39725036). Activated by some tick defensins, such as I.persulcatus Def1 and I.ricinus Def2, evoking itch (PubMed:33358893). Also activated by conotoxin CNF-Tx2, inducing itch sensation (PubMed:30243794, PubMed:37591889). Activated by the antimalarial drug chloroquine; however, activation requires concentrations that exceed the chloroquine concentrations observed in plasma of patients undergoing chloroquine treatment (PubMed:20004959). Also activated following cleavage by the dust mite cysteine protease Der p1 (PubMed:28768771). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:36302898, PubMed:37591889). MRGPRX1 is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, leading to sensitize TRPV1 in pruriceptors, while G(i) coupling mediates inhibition of adenylate cyclase activity (PubMed:23074220, PubMed:36302898, PubMed:37347749, PubMed:37591889). Activation of MRGPRX1 in the peripheral nervous system elicits itch, evoking scratching (PubMed:28223516). MRGPRX1 activation in sensory neurons of the nasal mucosa mediates sneezing responses to irritants or influenza-virus (By similarity). Activation in the central nervous system dampens chronic pain: BAM8-22-binding at the central terminals prevents pain signals passing to spinal cord neurons, attenuating spinal nociceptive transmission (PubMed:28223516). Activation by CXCL17 induces chemotactic movement (PubMed:41167449)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Publication Status: Online-Only, [RefSeq, PubMed]; Mechanism of agonist-induced activation of the human itch receptor MRGPRX1. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 37,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4V9L2;Q8TDD8;Q8TDD9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:1904057 negative regulation of sensory perception of pain;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q96LB2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NRJ1-1",
        "uniprot_id": "MOST1_HUMAN",
        "mass": 11219.0,
        "length": 99,
        "protein_name": "Protein MOST-1",
        "gene_name": "C8orf17",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "C8orf17",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Protein MOST-1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 9,
        "publication_id_list": "12665628;17143515;23481700;25418920;29437277;30410026;32938616;33936100;33968037",
        "class_list": "",
        "function": "May be involved in cell survival, proliferation and progression of cancer cells., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q9NRJ1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H081-1",
        "uniprot_id": "MIS12_HUMAN",
        "mass": 24140.0,
        "length": 205,
        "protein_name": "Protein MIS12 homolog",
        "gene_name": "MIS12",
        "organism": "Human",
        "refseq_name": "protein MIS12 homolog",
        "refseq_ac": "NP_001245146",
        "gene_names_uniprotkb": "MIS12",
        "gene_names_refseq": "2510025F08Rik; KNTC2AP; MIS12; MTW1; hMis12",
        "protein_names_uniprotkb": "Protein MIS12 homolog",
        "protein_names_refseq": "MIS12 homolog; MIS12, MIND kinetochore complex component, homolog; homolog of yeast Mis12; protein MIS12 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79003);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5663220);  (R-HSA-68877);  (R-HSA-9648025)",
        "pathway_count": 8,
        "publication_count": 95,
        "publication_id_list": "10411507;10600384;10678165;10958683;11081627;11181178;11230166;11237011;11371342;11509732;11535616;11804586;12006501;12194817;12429848;12515822;12577064;12679384;12732141;12805219;12852857;14730319;15006353;15085137;15339662;15502821;15507212;15723797;15737063;15864301;15866170;15944396;16292343;16439214;16541025;16585270;16622419;16622420;16682347;16890222;16943183;17030981;17112726;17113138;17129783;17196341;17198702;1737036;18001770;18097444;18716626;18923426;19350017;19696148;19815554;19965387;20030946;20101212;20591975;21111234;21148482;21397845;21576392;21868368;21878504;21987589;22094460;22275430;22608513;22790947;22885700;23222643;23801653;23891108;24914801;25740311;25789526;28832583;29242379;31154438;31409757;31844290;32357974;32983136;33035345;33392160;33592498;33912179;34185709;34260926;35580925;37938771;9649308;9649503;9892021",
        "class_list": "",
        "function": "HMIS12 has a role in mitosis and localizes at kinetochores, [RefSeq, PubMed]; METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA., [RefSeq, PubMed]; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; These results indicate that a four-subunit Mis12 complex plays an essential role in chromosome segregation in vertebrates and contributes to mitotic kinetochore assembly., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96N24",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005829 cytosol;GO:0000776 kinetochore;GO:0000940 outer kinetochore",
        "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051382 kinetochore assembly;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division",
        "synthesized_glycan_count": 0,
        "hit_score": 9.6,
        "record_id": "Q9H081-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q02252-1",
        "uniprot_id": "MMSA_HUMAN",
        "mass": 57840.0,
        "length": 535,
        "protein_name": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial",
        "gene_name": "ALDH6A1",
        "organism": "Human",
        "refseq_name": "methylmalonate-semialdehyde/malonate- semialdehyde dehydrogenase [acylating], mitochondrial isoform 2 precursor",
        "refseq_ac": "NP_001265522",
        "gene_names_uniprotkb": "ALDH6A1; MMSDH",
        "gene_names_refseq": "ALDH6A1; MMSADHA; MMSDH",
        "protein_names_uniprotkb": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial; 1.2.1.27; Aldehyde dehydrogenase family 6 member A1; MMSDH; Malonate-semialdehyde dehydrogenase [acylating]",
        "protein_names_refseq": "malonate-semialdehyde dehydrogenase (acetylating); methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; methylmalonate-semialdehyde/malonate- semialdehyde dehydrogenase [acylating], mitochondrial isoform 2 precursor; methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial; mitochondrial acylating methylmalonate-semialdehyde dehydrogenase; testicular tissue protein Li 122",
        "tax_id": 9606,
        "disease": "methylmalonate semialdehyde dehydrogenase deficiency (MONDO:MONDO:0013579)",
        "pathway": " (hsa:4329);  (R-HSA-70895)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "10832746;10947204;11013134;11181649;11237011;11264579;11406611;11738050;12269802;12359132;12434311;12696021;13416257;14752098;15166214;1527093;15342248;15576032;16023992;16141215;17371050;19343046;22291014;22956686;23481700;23485643;23835272;24275569;24449431;25892735;26251176;26992070;27846572;27920218;28411811;29769354;30379171;30429286;3082934;31217245;31435015;31844290;31985234;32157095;32387766;33686951;33912179;34087483;34171305;34229054;35051231;35580925;35907565;3597357;36010968;36098688;37217939;6928646;7356336;8824301;9165094;9214289;9889013",
        "class_list": "",
        "function": "ALDH6A1 weakens the progression of colon cancer via modulating the RAS/RAF/MEK/ERK pathway in cancer cell lines., [RefSeq, PubMed]; Identification and validation of a two-gene metabolic signature for survival prediction in patients with kidney renal clear cell carcinoma., [RefSeq, PubMed]; Identification of ALDH6A1 as a Potential Molecular Signature in Hepatocellular Carcinoma via Quantitative Profiling of the Mitochondrial Proteome., [RefSeq, PubMed]; Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine., [UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The downregulated drug-metabolism related ALDH6A1 serves as predictor for prognosis and therapeutic immune response in gastric cancer., [RefSeq, PubMed]; This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R609;B4DFS8;J3KNU8;Q9UKM8",
        "ec_number_list": "1.2.1.27",
        "go_molecular_function": "GO:0003723 RNA binding;GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006210 thymine catabolic process;GO:0009083 branched-chain amino acid catabolic process;GO:0006574 L-valine catabolic process;GO:0006573 valine metabolic process;GO:0019859 thymine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q02252-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q96PC5-3",
        "uniprot_id": "MIA2_HUMAN",
        "mass": 159836.0,
        "length": 1412,
        "protein_name": "Melanoma inhibitory activity protein 2",
        "gene_name": "MIA2",
        "organism": "Human",
        "refseq_name": "melanoma inhibitory activity protein 2 isoform 8 precursor",
        "refseq_ac": "NP_001316143",
        "gene_names_uniprotkb": "MIA2; CTAGE5; MEA11; MEA6; MGEA11; MGEA6",
        "gene_names_refseq": "CTAGE5; MEA6; MGEA11; MGEA6; MGEA; MIA2; TALI",
        "protein_names_uniprotkb": "Melanoma inhibitory activity protein 2; CTAGE family member 5 ER export factor; Cutaneous T-cell lymphoma-associated antigen 5; MIA protein 2; Meningioma-expressed antigen 6/11",
        "protein_names_refseq": "CTAGE family member 5, ER export factor; CTAGE family, member 5; MIA protein 2; TANGO1-like; cutaneous T-cell lymphoma-associated antigen 5; melanoma inhibitory activity 2; melanoma inhibitory activity protein 2 isoform 8 precursor; melanoma inhibitory activity protein 2; meningioma expressed antigen 6 (coiled-coil proline-rich); meningioma-expressed antigen 6/11; protein cTAGE-5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4253);  (R-HSA-5694530)",
        "pathway_count": 2,
        "publication_count": 83,
        "publication_id_list": "10.1101/2023.09.13.557529;10559958;10652252;12237308;12586826;12839582;16129679;16959974;17010120;17499046;17607000;18025080;18283111;18287528;18843296;19265014;19269366;19566487;20427317;20477988;20533886;20805473;21525241;21807889;21878990;22013193;22299025;23852824;25202031;25367160;25576301;25619253;26375851;27138255;27170179;27551091;27600516;27862975;28218747;28442536;28832583;29242379;29314611;29331515;29393594;29493099;29513218;29557506;29632711;29786170;29789417;30192525;30315122;31154438;31844290;32157095;32350084;32357974;32502341;32938616;32983136;33298915;33592498;33912179;33936100;33968037;33981976;34087483;34171305;34357683;35051231;35154160;35561310;35580925;36215666;36241641;36284347;37074911;38740147;40914422;9356211;9395526;9472029",
        "class_list": "",
        "function": "In this study, we identified specific and critical residues in the Sec12-binding region of cTAGE5 (E75A K76A, K89A, and S97A) and confirmed that cTAGE5-mediated Sec12 accumulation at ER exit sites is required for collagen VII secretion., [RefSeq, PubMed]; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; TANGO1/CTAGE5 receptor serves as a polyvalent template for assembly of large COPII coats., [RefSeq, PubMed]; These data showed that the NRZ tether is required for TANGO1 to assemble into a ring and indicated that stable complexes of TANGO1, cTAGE5 and TANGO1-short, recruit the tether. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A193H6U5;A1L4H0;B3KRA6;B4DQS6;D3DSA6;G3XAC5;O00169;O15320;Q6MZN2;Q6P2R8;Q86TF6;Q8IX92;Q8IX93;Q9H6C1",
        "ec_number_list": "",
        "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0038024 cargo receptor activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site",
        "go_biological_process": "GO:0042953 lipoprotein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009306 protein secretion;GO:0070973 protein localization to endoplasmic reticulum exit site;GO:0032527 protein exit from endoplasmic reticulum",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "Q96PC5-3",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9H2W2-1",
        "uniprot_id": "MIXL1_HUMAN",
        "mass": 24659.0,
        "length": 232,
        "protein_name": "Homeobox protein MIXL1",
        "gene_name": "MIXL1",
        "organism": "Human",
        "refseq_name": "homeobox protein MIXL1 isoform 1",
        "refseq_ac": "NP_001269331",
        "gene_names_uniprotkb": "MIXL1; MIXL",
        "gene_names_refseq": "MILD1; MIXL1; MIXL; MIX",
        "protein_names_uniprotkb": "Homeobox protein MIXL1; Homeodomain protein MIX; MIX1 homeobox-like protein 1; Mix.1 homeobox-like protein; hMix",
        "protein_names_refseq": "MIX1 homeobox-like protein 1; Mix-like homeobox protein 1; homeobox protein MIXL1 isoform 1; homeobox protein MIXL1; homeodomain protein MIX; mix.1 homeobox-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83881);  (R-HSA-9754189);  (R-HSA-9823730)",
        "pathway_count": 3,
        "publication_count": 34,
        "publication_id_list": "11084649;12070013;15110706;15982639;16433620;17068183;17204604;17224082;17303500;18032708;18042803;18550259;18729794;19564924;21245162;21630377;21855631;22164283;25521758;25544748;25693565;25843708;25921273;25936800;26015544;27705785;29234012;30379171;30629940;32448362;32795420;35561310;39894887;9417125",
        "class_list": "",
        "function": "Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity, [RefSeq, PubMed]; Findings support the existence of a novel MIXL1-c REL mediated survival axis in AML that can be targeted by BMPR1 inhibitors. (MIXL1- human gene, Mixl1- mouse ortholog, MIXL1- protein)., [RefSeq, PubMed]; MIXL1 protein is differentially expressed in non-Hodgkin lymphoma and Hodgkin lymphoma; findings suggest that MIXL1 overexpression may play a role in driving proliferatin or blocking differentiation in lymphoma oncogenesis, [RefSeq, PubMed]; Results demonstrate that Mixl1 and Flk1 play roles...during dimethyl sulfoxide-induced mesodermal specification in P19 cells., [RefSeq, PubMed]; Shows functional similarity to Xenopus Mix.1, [RefSeq, PubMed]; Targeted insertion in human embryonic stem cells of sequences encoding green fluorescent protein (GFP) into the locus of MIXL1, a gene transiently expressed in the primitive streak during embryogenesis., [RefSeq, PubMed]; These results demonstrate for a functional role for TGF-beta ligands in regulation of mammalian Mixl1, identify FoxH1 as an essential co-activator, and implicate Nodal as the embryonic regulator of Mixl1 in mesendoderm morphogenesis., [RefSeq, PubMed]; Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZLF9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048565 digestive tract development",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q9H2W2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9NRE1-1",
        "uniprot_id": "MMP26_HUMAN",
        "mass": 29708.0,
        "length": 261,
        "protein_name": "Matrix metalloproteinase-26",
        "gene_name": "MMP26",
        "organism": "Human",
        "refseq_name": "matrix metalloproteinase-26 isoform 1 preproprotein",
        "refseq_ac": "NP_068573",
        "gene_names_uniprotkb": "MMP26",
        "gene_names_refseq": "MMP26",
        "protein_names_uniprotkb": "Matrix metalloproteinase-26; 3.4.24.-; Endometase; MMP-26; Matrilysin-2",
        "protein_names_refseq": "MMP-26; endometase; matrilysin 2; matrix metalloproteinase-26 isoform 1 preproprotein; matrix metalloproteinase-26",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56547)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "10801841;10824119;10987280;11237011;11389678;25262277;25566961;26279442;27143441;29270749",
        "class_list": "",
        "function": "MMP26 is overexpressed in prostatic neoplasms patients, and can serve as a serum disease biomarker., [RefSeq, PubMed]; MMP26+CXCR4+ cells may be circulating tumor cells in hepatocellular carcinoma., [RefSeq, PubMed]; May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B., [UniProtKB]; Overexpression of MMP26 in SW1353 cells increased cell invasiveness, while inhibition of MMP26 decreased cell invasiveness., [RefSeq, PubMed]; Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016]., [RefSeq]; The luciferase report assay demonstrated that MMP26 is a target gene of miR-125b. And the expression profile of MMP26 showed an inverse relationship with miR-125b in vivo and in vitro. Publication Status: Online-Only, [RefSeq, PubMed]; We found that only inhibition of JNK significantly decreased the activation of MMP26 in response to FGF1 stimulation, suggesting that activation of FGFR1 signaling may activate JNK to activate MMP26 in non-small-cell lung cancer, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3MJ78;Q9GZS2;Q9NR87",
        "ec_number_list": "",
        "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0050728 negative regulation of inflammatory response;GO:0030574 collagen catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q9NRE1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UNW1-1",
        "uniprot_id": "MINP1_HUMAN",
        "mass": 55051.0,
        "length": 487,
        "protein_name": "Multiple inositol polyphosphate phosphatase 1",
        "gene_name": "MINPP1",
        "organism": "Human",
        "refseq_name": "multiple inositol polyphosphate phosphatase 1 isoform 2 precursor",
        "refseq_ac": "NP_001171588",
        "gene_names_uniprotkb": "MINPP1; MIPP; PRO1917",
        "gene_names_refseq": "HIPER1; MINPP1; MINPP2; MIPP; PCH16",
        "protein_names_uniprotkb": "Multiple inositol polyphosphate phosphatase 1; 2,3-BPG phosphatase; 2,3-bisphosphoglycerate 3-phosphatase; 3.1.3.62; 3.1.3.80",
        "protein_names_refseq": "2,3-BPG phosphatase; 2,3-bisphosphoglycerate 3-phosphatase; inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; ins(1,3,4,5)P(4) 3-phosphatase; multiple inositol polyphosphate histidine phosphatase, 1; multiple inositol polyphosphate phosphatase 1 isoform 2 precursor; multiple inositol polyphosphate phosphatase 2",
        "tax_id": 9606,
        "disease": "pontocerebellar hypoplasia type 16 (Disease Ontology:DOID:0112333); follicular thyroid carcinoma (Disease Ontology:DOID:3962); papillary thyroid carcinoma (Disease Ontology:DOID:3969)",
        "pathway": " (hsa:9562);  (R-HSA-1855231)",
        "pathway_count": 2,
        "publication_count": 83,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10087200;11230166;11297621;12975309;15979280;16335952;1653239;16759730;18413611;19664994;22424782;22661428;23090970;23481700;23584533;24190977;24397554;25502872;25813380;25892735;26375851;26811146;26992070;27038811;27543614;27600516;27846572;28218747;28228285;28510447;28514659;28832583;28904123;29242379;29249144;29314611;29393594;29557506;29632711;29741879;30315122;30459171;31217245;31530632;31611695;31844290;32157095;32350084;32357974;32387766;32938616;32983136;33141586;33168985;33257696;33298915;33592498;33912179;33936100;33968037;33981976;34171305;34357683;34405274;34725712;34932366;35051231;35251023;35254053;35289036;35561310;35580925;36010968;36241641;36589890;37074911;38665916;40307207;40596516;9923613",
        "class_list": "",
        "function": "MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. Publication Status: Online-Only, [RefSeq, PubMed]; Minpp1 exhibits characteristics of a stress responsive molecule during Endoplasmic reticulum stress-induced apoptosis, [RefSeq, PubMed]; Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed:33257696, PubMed:36589890). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant (PubMed:36589890). By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis (PubMed:33257696). May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (PubMed:18413611)., [UniProtKB, PubMed, PubMed, PubMed]; Pontocerebellar hypoplasia due to bi-allelic variants in MINPP1., [RefSeq, PubMed]; This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 7,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 15,
        "disease_count": 3,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F5H683;O95172;O95286;Q59EJ2;Q9UGA3",
        "ec_number_list": "3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.1.3.62;3.1.3.80",
        "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0030351 inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity;GO:0034417 bisphosphoglycerate 3-phosphatase activity;GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity;GO:0052745 inositol phosphate phosphatase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0001503 ossification;GO:0030282 bone mineralization;GO:0030003 intracellular monoatomic cation homeostasis;GO:0043647 inositol phosphate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q9UNW1-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A0A1B0GTQ4-1",
        "uniprot_id": "MYMX_HUMAN",
        "mass": 9607.0,
        "length": 84,
        "protein_name": "Protein myomixer",
        "gene_name": "MYMX",
        "organism": "Human",
        "refseq_name": "protein myomixer",
        "refseq_ac": "NP_001302423",
        "gene_names_uniprotkb": "MYMX",
        "gene_names_refseq": "CFZS2; MINION; MYMX; hMINION",
        "protein_names_uniprotkb": "Protein myomixer; Microprotein inducer of fusion; Protein minion; hMINION",
        "protein_names_refseq": "microprotein inducer of fusion; myomerger; protein minion; protein myomixer",
        "tax_id": 9606,
        "disease": "Carey-Fineman-Ziter syndrome 2 (Disease Ontology:DOID:0061116)",
        "pathway": " (hsa:101929726)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "28569745;31642939;35642635;35736212",
        "class_list": "",
        "function": "LncRNA OIP5-AS1-directed miR-7 degradation promotes MYMX production during human myogenesis., [RefSeq, PubMed]; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:28569745, PubMed:35642635). Involved in membrane fusion downstream of the lipid mixing step mediated by MYMK (By similarity). Acts by generating membrane stresses via its extracellular C-terminus, leading to drive fusion pore formation. Acts independently of MYMK (By similarity). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; This articles reviews and discusses the latest studies related to Myomaker and Myomixer-Myomerger-Minion, including the discovery, structure, expression pattern, functions of the two proteins. [review] Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A223PZB9",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0060538 skeletal muscle organ development;GO:0007520 myoblast fusion;GO:0014905 myoblast fusion involved in skeletal muscle regeneration;GO:0045026 plasma membrane fusion",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "A0A1B0GTQ4-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NI61-1",
        "uniprot_id": "MYMK_HUMAN",
        "mass": 24699.0,
        "length": 221,
        "protein_name": "Protein myomaker",
        "gene_name": "MYMK",
        "organism": "Human",
        "refseq_name": "protein myomaker",
        "refseq_ac": "NP_001073952",
        "gene_names_uniprotkb": "MYMK; TMEM226; TMEM8C",
        "gene_names_refseq": "MYMK; MYOMAKER; TMEM226; TMEM8C",
        "protein_names_uniprotkb": "Protein myomaker; Myoblast fusion maker; Transmembrane protein 226; Transmembrane protein 8C",
        "protein_names_refseq": "myoblast fusion maker; protein myomaker; transmembrane protein 226; transmembrane protein 8C",
        "tax_id": 9606,
        "disease": "Carey-Fineman-Ziter syndrome 1 (Disease Ontology:DOID:0061115); Carey-Fineman-Ziter syndrome (Disease Ontology:DOID:0080194)",
        "pathway": " (hsa:389827)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "24715725;28681861;29242379;30065953;31642939;32488085;34288723",
        "class_list": "",
        "function": "Can we talk about myoblast fusion?, [RefSeq, PubMed]; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:28681861). Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX. Acts independently of MYMX (By similarity). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (By similarity). Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satellite cells with myofibers (By similarity)., [UniProtKB, PubMed, UniProtKB]; The data establish that MYMK activity is necessary for normal muscle development and maintenance in humans and zebrafish, and expand the spectrum of congenital myopathies to include cell-cell fusion deficits. Publication Status: Online-Only, [RefSeq, PubMed]; This articles reviews and discusses the latest studies related to Myomaker and Myomixer-Myomerger-Minion, including the discovery, structure, expression pattern, functions of the two proteins. [review] Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007517 muscle organ development;GO:0007520 myoblast fusion;GO:1904206 positive regulation of skeletal muscle hypertrophy;GO:0045026 plasma membrane fusion",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "A6NI61-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O60682-1",
        "uniprot_id": "MUSC_HUMAN",
        "mass": 22068.0,
        "length": 206,
        "protein_name": "Musculin",
        "gene_name": "MSC",
        "organism": "Human",
        "refseq_name": "musculin",
        "refseq_ac": "NP_005089",
        "gene_names_uniprotkb": "MSC; ABF1; BHLHA22",
        "gene_names_refseq": "ABF-1; ABF1; MSC; MYOR; bHLHa22",
        "protein_names_uniprotkb": "Musculin; ABF-1; Activated B-cell factor 1; Class A basic helix-loop-helix protein 22; bHLHa22",
        "protein_names_refseq": "activated B-cell factor 1, homolog of mouse musculin; activated B-cell factor-1; class A basic helix-loop-helix protein 22; musculin",
        "tax_id": 9606,
        "disease": "end stage renal disease (Disease Ontology:DOID:783)",
        "pathway": " (hsa:9242)",
        "pathway_count": 1,
        "publication_count": 44,
        "publication_id_list": "15052269;23481700;24714562;24715725;25802875;26154972;27846572;27862975;27920218;28612433;28832583;28904123;29242379;29493099;29508533;29557506;30315122;30379171;31101622;31154438;31675985;31844290;31937595;31998317;32157095;32357974;32502341;32983136;33141586;33298915;33912179;33936100;34185709;34211107;34357683;34433824;34561969;34932366;34992594;35051231;35580925;36284347;9584154;9767165",
        "class_list": "",
        "function": "Results found that MSC hypermethylation was more common in non-superficial type gastric cancer (GC) than those without MSC hypermethylation. Publication Status: Online-Only, [RefSeq, PubMed]; Role in repressing lymphotoxin alpha, [RefSeq, PubMed]; The Pathogenic Roles of IL-22 in Colitis: Its Transcription Regulation by Musculin in T Helper Subsets and Innate Lymphoid Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]., [RefSeq]; These findings identify a novel recurrent MSC mutation as a key driver of the CD30-IRF4-MYC axis and cell cycle progression in a unique subset of anaplastic large cell lymphomas, [RefSeq, PubMed]; This study shows that musculin inhibits human T-helper 17 cell response to interleukin 2 by controlling STAT5B activity, [RefSeq, PubMed]; Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75946;Q53XZ2;Q9BRE7",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0060021 roof of mouth development;GO:0007519 skeletal muscle tissue development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "O60682-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P11055-1",
        "uniprot_id": "MYH3_HUMAN",
        "mass": 223905.0,
        "length": 1940,
        "protein_name": "Myosin-3",
        "gene_name": "MYH3",
        "organism": "Human",
        "refseq_name": "myosin-3",
        "refseq_ac": "NP_002461",
        "gene_names_uniprotkb": "MYH3",
        "gene_names_refseq": "CPSFS1A; CPSFS1B; CPSKF1A; CPSKF1B; DA2A; DA2B3; DA2B; DA8; HEMHC; MYH3; MYHC-EMB; MYHSE1; SMHCE",
        "protein_names_uniprotkb": "Myosin-3; Muscle embryonic myosin heavy chain; Myosin heavy chain 3; Myosin heavy chain, fast skeletal muscle, embryonic; SMHCE",
        "protein_names_refseq": "myosin heavy chain, fast skeletal muscle, embryonic; myosin, heavy chain 3, skeletal muscle, embryonic; myosin, heavy polypeptide 3, skeletal muscle, embryonic; myosin, skeletal, heavy chain, embryonic 1; myosin-3",
        "tax_id": 9606,
        "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); contractures, pterygia, and spondylocarpotarsal fusion syndrome (Disease Ontology:DOID:0080110); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A (Disease Ontology:DOID:0081321); contractures, pterygia, and spondylocarpotarsal fusion syndrome 1B (Disease Ontology:DOID:0081322); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B (Disease Ontology:DOID:0111599); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)",
        "pathway": " (hsa:4621);  (R-HSA-390522)",
        "pathway_count": 2,
        "publication_count": 27,
        "publication_id_list": "10747208;16642020;1691980;18452278;18695058;25957469;2726495;27381093;2771643;2806546;29314551;29493099;29508533;29805041;31844290;32387766;32502341;32767732;32902138;33392160;35051231;35580925;36215666;36284347;37245538;38444278;38856159",
        "class_list": "",
        "function": "Bi-allelic variants in MYH3 cause recessively-inherited arthrogryposis., [RefSeq, PubMed]; Functional assessment of a novel biallelic MYH3 variation causing CPSKF1B (contractures, pterygia, and spondylocarpotarsal fusion syndrome1B)., [RefSeq, PubMed]; Identification of a novel pathogenic variant in the MYH3 gene in a five-generation family with CPSFS1A (Contractures, Pterygia, and Spondylocarpotarsal Fusion Syndrome 1A)., [RefSeq, PubMed]; METTL3 achieves lipopolysaccharide-induced myocardial injury via m[6]A-dependent stabilization of Myh3 mRNA., [RefSeq, PubMed]; Muscle contraction., [UniProtKB]; Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq, Jul 2008]., [RefSeq]; Recessive MYH3 variants cause ''Contractures, pterygia, and variable skeletal fusions syndrome 1B'' mimicking Escobar variant multiple pterygium syndrome., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 19,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15492",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0017018 myosin phosphatase activity",
        "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0030017 sarcomere",
        "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0006936 muscle contraction;GO:0007517 muscle organ development;GO:0030049 muscle filament sliding;GO:0030326 embryonic limb morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "P11055-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P12524-1",
        "uniprot_id": "MYCL_HUMAN",
        "mass": 40327.0,
        "length": 364,
        "protein_name": "Protein L-Myc",
        "gene_name": "MYCL",
        "organism": "Human",
        "refseq_name": "protein L-Myc isoform 1",
        "refseq_ac": "NP_001028253",
        "gene_names_uniprotkb": "MYCL; BHLHE38; LMYC; MYCL1",
        "gene_names_refseq": "L-Myc; LMYC; MYCL1; MYCL; bHLHe38",
        "protein_names_uniprotkb": "Protein L-Myc; Class E basic helix-loop-helix protein 38; Protein L-Myc-1; V-myc myelocytomatosis viral oncogene homolog; bHLHe38",
        "protein_names_refseq": "class E basic helix-loop-helix protein 38; l-myc-1 proto-oncogene; myc-related gene from lung cancer; protein L-Myc isoform 1; protein L-Myc-1; v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog; v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4610)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;18510355;2548855;28228285;2827002;28904123;29393594;31844290;3322939;33691108;34930932;35318648;36177900;37827180",
        "class_list": "",
        "function": "Comparative study on the mutation spectrum of L-MYC and C-MYC genes of blood cfDNA in patients with ovarian cancer and healthy females., [RefSeq, PubMed]; MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains. Publication Status: Online-Only, [RefSeq, PubMed]; MYCL promotes the progression of triplenegative breast cancer by activating the JAK/STAT3 pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A2C9;B4DJH2;Q14897;Q5QPL0;Q5QPL1;Q9NUE9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005694 chromosome",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "P12524-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P12525-1",
        "uniprot_id": "MYCP1_HUMAN",
        "mass": 40868.0,
        "length": 358,
        "protein_name": "Putative myc-like protein MYCLP1",
        "gene_name": "MYCLP1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "MYCLP1; MYCL1P1; MYCL2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative myc-like protein MYCLP1; Protein L-Myc-2; V-myc myelocytomatosis viral oncogene homolog pseudogene 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 4,
        "publication_id_list": "1711681;2541066;33392160;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "O43372",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "P12525-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P12882-1",
        "uniprot_id": "MYH1_HUMAN",
        "mass": 223145.0,
        "length": 1939,
        "protein_name": "Myosin-1",
        "gene_name": "MYH1",
        "organism": "Human",
        "refseq_name": "myosin-1",
        "refseq_ac": "NP_005954",
        "gene_names_uniprotkb": "MYH1",
        "gene_names_refseq": "HEL71; MYH1; MYHSA1; MYHa; MyHC-2X/D; MyHC-2x",
        "protein_names_uniprotkb": "Myosin-1; MyHC-2x; MyHC-IIx/d; Myosin heavy chain 1; Myosin heavy chain 2x; Myosin heavy chain IIx/d; Myosin heavy chain, skeletal muscle, adult 1",
        "protein_names_refseq": "epididymis luminal protein 71; myHC-IIx/d; myosin heavy chain 2x; myosin heavy chain IIx/d; myosin heavy chain, skeletal muscle, adult 1; myosin, heavy chain 1, skeletal muscle, adult; myosin, heavy polypeptide 1, skeletal muscle, adult; myosin-1",
        "tax_id": 9606,
        "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)",
        "pathway": " (hsa:4619)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10388558;16959974;18987736;20068231;20112406;21248752;2421254;25567808;25576301;26059207;27862975;29237092;29557506;32938616;33392160;33755318;34171305;35051231;35580925;36284347;37938771;38253038;39482536",
        "class_list": "",
        "function": "MYH1 is a candidate gene for recurrent rhabdomyolysis in humans., [RefSeq, PubMed]; Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008]., [RefSeq]; Myosin isoforms impact single-fiber force generation and may lead to alterations in whole skeletal muscle performance., [RefSeq, PubMed]; Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility., [UniProtKB, UniProtKB]; Transcriptional levels of MHC-I, MHC-IIa, and MHC-IIb in denervation groups were significantly down-regulated compared with controls, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 37,
        "reported_mutagensis": 0,
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        "reported_snv": 72,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 15,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14CA4;Q9Y622",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity",
        "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0014704 intercalated disc;GO:0032982 myosin filament;GO:0036464 cytoplasmic ribonucleoprotein granule",
        "go_biological_process": "GO:0006936 muscle contraction;GO:0007605 sensory perception of sound",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "P12882-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P13533-1",
        "uniprot_id": "MYH6_HUMAN",
        "mass": 223735.0,
        "length": 1939,
        "protein_name": "Myosin-6",
        "gene_name": "MYH6",
        "organism": "Human",
        "refseq_name": "myosin-6",
        "refseq_ac": "NP_002462",
        "gene_names_uniprotkb": "MYH6; MYHCA",
        "gene_names_refseq": "ASD3; CMD1EE; CMH14; MYH6; MYHCA; MYHC; SSS3; alpha-MHC",
        "protein_names_uniprotkb": "Myosin-6; MyHC-alpha; Myosin heavy chain 6; Myosin heavy chain, cardiac muscle alpha isoform",
        "protein_names_refseq": "myHC-alpha; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1); myosin-6",
        "tax_id": 9606,
        "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); spondylocarpotarsal synostosis syndrome (Disease Ontology:DOID:0090116); atrial heart septal defect 3 (Disease Ontology:DOID:0110108); hypertrophic cardiomyopathy 1 (Disease Ontology:DOID:0110307); hypertrophic cardiomyopathy 14 (Disease Ontology:DOID:0110320); dilated cardiomyopathy 1EE (Disease Ontology:DOID:0110453); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); sick sinus syndrome (Disease Ontology:DOID:13884); hypothyroidism (Disease Ontology:DOID:1459); atrial heart septal defect (Disease Ontology:DOID:1882); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); sick sinus syndrome 3, susceptibility to (MONDO:MONDO:0013568)",
        "pathway": " (hsa:4624);  (R-HSA-390522)",
        "pathway_count": 2,
        "publication_count": 25,
        "publication_id_list": "10747208;11815426;15735645;15998695;1776652;21378987;24715725;2726733;28832583;29557506;2969919;3037493;31844290;32983136;33592498;34019948;35051231;36215666;36284347;36385524;38135727;38340456;38971138;39181964;8307559",
        "class_list": "",
        "function": "Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located approximately 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. [provided by RefSeq, Feb 2017]., [RefSeq]; Heart proteomic profiling discovers MYH6 and COX5B as biomarkers for sudden unexplained death., [RefSeq, PubMed]; MYH6 suppresses tumor progression by downregulating KIT expression in human prostate cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Muscle contraction., [UniProtKB]; Tetralogy of Fallot: variants of MYH6 gene promoter and cellular functional analyses., [RefSeq, PubMed]; Variants of the promoter of MYH6 gene in congenital isolated and sporadic patent ductus arteriosus: case-control study and cellular functional analyses., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 27,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RTX1;D9YZU2;Q13943;Q14906;Q14907",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0051015 actin filament binding;GO:0017018 myosin phosphatase activity",
        "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001725 stress fiber;GO:0030017 sarcomere",
        "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006936 muscle contraction;GO:0008217 regulation of blood pressure;GO:0008016 regulation of heart contraction;GO:0030049 muscle filament sliding",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "P13533-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P13535-1",
        "uniprot_id": "MYH8_HUMAN",
        "mass": 222763.0,
        "length": 1937,
        "protein_name": "Myosin-8",
        "gene_name": "MYH8",
        "organism": "Human",
        "refseq_name": "myosin-8",
        "refseq_ac": "NP_002463",
        "gene_names_uniprotkb": "MYH8",
        "gene_names_refseq": "DA7; MYH8; MyHC-peri; MyHC-pn; gtMHC-F",
        "protein_names_uniprotkb": "Myosin-8; MyHC-perinatal; Myosin heavy chain 8; Myosin heavy chain, skeletal muscle, perinatal",
        "protein_names_refseq": "fetal-myosin heavy chain; myHC-perinatal; myosin heavy chain, skeletal muscle, perinatal; myosin, heavy chain 8, skeletal muscle, perinatal; myosin, heavy polypeptide 8, skeletal muscle, perinatal; myosin-8",
        "tax_id": 9606,
        "disease": "Carney complex (Disease Ontology:DOID:0050471); distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 7 (Disease Ontology:DOID:0111603); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); disease of cellular proliferation (Disease Ontology:DOID:14566); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423); muscular dystrophy (Disease Ontology:DOID:9884)",
        "pathway": " (hsa:4626);  (R-HSA-390522)",
        "pathway_count": 2,
        "publication_count": 21,
        "publication_id_list": "10747208;15282353;1691980;18452278;20949528;2373371;25576301;2715179;28508505;29557506;29786170;30524438;31430364;32232851;32265295;32308057;33936100;35051231;35580925;7601129;8315383",
        "class_list": "",
        "function": "Muscle contraction., [UniProtKB]; Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is predominantly expressed in fetal skeletal muscle. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. [provided by RefSeq, Sep 2009]., [RefSeq]; Novel MYH8 mutations in 152 Han Chinese samples with ovarian endometriosis., [RefSeq, PubMed]; Novel exomic rare variants associated with venous thrombosis., [RefSeq, PubMed]; There was an immediate shutdown of the MHC IIX gene after resistance exercise. Silencing of the MHC IIX gene is sustained at least 4 days after removal of the stimulus., [RefSeq, PubMed]; Truncation of MYH8 tail in AML: a novel prognostic marker with increase cell migration and epithelial-mesenchymal transition utilizing RAF/MAPK pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 34,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 20,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14910",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0008307 structural constituent of muscle",
        "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030017 sarcomere;GO:0032982 myosin filament",
        "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0006936 muscle contraction;GO:0030049 muscle filament sliding;GO:0046034 ATP metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "P13535-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P15172-1",
        "uniprot_id": "MYOD1_HUMAN",
        "mass": 34501.0,
        "length": 320,
        "protein_name": "Myoblast determination protein 1",
        "gene_name": "MYOD1",
        "organism": "Human",
        "refseq_name": "myoblast determination protein 1",
        "refseq_ac": "NP_002469",
        "gene_names_uniprotkb": "MYOD1; BHLHC1; MYF3; MYOD",
        "gene_names_refseq": "CMYO17; CMYP17; MYF3; MYOD1; MYODRIF; MYOD; PUM; bHLHc1",
        "protein_names_uniprotkb": "Myoblast determination protein 1; Class C basic helix-loop-helix protein 1; Myf-3; Myogenic factor 3; bHLHc1",
        "protein_names_refseq": "class C basic helix-loop-helix protein 1; myf-3; myoblast determination protein 1; myogenic factor 3",
        "tax_id": 9606,
        "disease": "congenital myopathy 17 (Disease Ontology:DOID:0081349); hypertension (Disease Ontology:DOID:10763); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:4654);  (R-HSA-525793);  (R-HSA-9839394);  (R-HSA-9943411)",
        "pathway_count": 4,
        "publication_count": 63,
        "publication_id_list": "10199952;10330143;10601328;10805738;10942602;11532390;11782431;12037670;12415271;12634428;12682017;1335366;14749395;15647753;16263726;16372014;16858404;16959974;17014844;17433364;17717186;18042460;18299279;1850513;19564926;20026657;20160094;20211137;21212806;21454680;21902831;22046413;22215600;22569126;22922743;24860983;25751651;2583111;26733463;27562493;27661449;30403323;30467960;31260566;31409900;33542304;33913590;35012940;35580925;37217939;37222488;38102140;38701194;40023397;9069290;9418854;9546368;9710583;9751114;9774340;9786951;9858528;9988769",
        "class_list": "",
        "function": "Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity)., [UniProtKB]; Functional impact and targetability of PI3KCA, GNAS, and PTEN mutations in a spindle cell rhabdomyosarcoma with MYOD1 L122R mutation. Erratum:[Cold Spring Harb Mol Case Stud. 2022 Apr 28;8(3):a006216. doi: 10.1101/mcs.a006216. PMID: 35483883] Publication Status: Online-Only, [RefSeq, PubMed]; MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57[Kip2] targeting. Publication Status: Online-Only, [RefSeq, PubMed]; MYOD1 as a prognostic indicator in rhabdomyosarcoma., [RefSeq, PubMed]; MyoD1 promotes the transcription of BIK and plays an apoptosis-promoting role in the development of gastric cancer., [RefSeq, PubMed]; The nuclear import of the transcription factor MyoD is reduced in mesenchymal stem cells grown in a 3D micro-engineered niche. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75321",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0030016 myofibril",
        "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0014904 myotube cell development;GO:0043335 protein unfolding;GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "P15172-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P22033-1",
        "uniprot_id": "MUTA_HUMAN",
        "mass": 83134.0,
        "length": 750,
        "protein_name": "Methylmalonyl-CoA mutase, mitochondrial",
        "gene_name": "MMUT",
        "organism": "Human",
        "refseq_name": "methylmalonyl-CoA mutase, mitochondrial precursor",
        "refseq_ac": "NP_000246",
        "gene_names_uniprotkb": "MMUT; MUT",
        "gene_names_refseq": "MCM; MMUT; MUT",
        "protein_names_uniprotkb": "Methylmalonyl-CoA mutase, mitochondrial; 5.4.99.2; MCM; Methylmalonyl-CoA isomerase",
        "protein_names_refseq": "methylmalonyl Coenzyme A mutase; methylmalonyl-CoA isomerase; methylmalonyl-CoA mutase c.*192delA; methylmalonyl-CoA mutase c.*51C>G; methylmalonyl-CoA mutase variant c.1495G>A; methylmalonyl-CoA mutase variant c.2011A>G; methylmalonyl-CoA mutase variant c.2150G>T; methylmalonyl-CoA mutase variant c.322C>T; methylmalonyl-CoA mutase variant c.613_615delGAA; methylmalonyl-CoA mutase variant c.636G>A; methylmalonyl-CoA mutase variant c.643G>A; methylmalonyl-CoA mutase, mitochondrial precursor; methylmalonyl-CoA mutase, mitochondrial; mutant methylmalonyl CoA mutase",
        "tax_id": 9606,
        "disease": "methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency (Disease Ontology:DOID:0060740); methylmalonic acidemia (Disease Ontology:DOID:14749)",
        "pathway": " (hsa:4594);  (R-HSA-3359475);  (R-HSA-3359478);  (R-HSA-71032);  (R-HSA-9759218)",
        "pathway_count": 5,
        "publication_count": 109,
        "publication_id_list": "10444342;10484769;10923046;10978155;11350191;11481338;11528502;12375236;12438653;12514191;1346616;1351030;13752080;13934211;15523652;15643616;15781192;15913339;16023992;16281286;16311595;16451139;1670635;16866376;17113806;17477549;17892308;17957493;18251506;18385497;18779575;19243433;19447654;19588269;1970180;1977311;1978672;19801555;1980486;20068231;20657474;20876572;21071249;21138732;21697092;22156578;22727635;22832074;23270877;24275569;24458;2453061;24715725;25125334;25576301;25645385;2567699;25892735;26154972;26615597;26992070;27167370;27452731;27600516;27846572;27862975;28101778;28228285;28510447;28832583;28834231;28904123;28943303;29056341;29557506;29769354;29789417;30282455;30315122;30379171;30429286;31844290;32157095;32387766;32488085;32938616;33043033;33592498;33630763;33717175;33797888;33968037;34171305;34932366;35051231;35580925;37938771;38128819;38253038;40108300;4390543;6765947;7909321;7912889;8968737;8990001;9285782;9452100;9554742",
        "class_list": "",
        "function": "Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Genetic analysis of isolated methylmalonic acidemia in Henan, China: c.1663G>A variant of MMUT prevalent in the Henan population., [RefSeq, PubMed]; This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K953;Q5SYZ3;Q96B11;Q9UD64",
        "ec_number_list": "5.4.99.2;3.6.-.-",
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0031419 cobalamin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0050667 homocysteine metabolic process;GO:1901290 succinyl-CoA biosynthetic process;GO:0019678 propionate metabolic process, methylmalonyl pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "P22033-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P23409-1",
        "uniprot_id": "MYF6_HUMAN",
        "mass": 26953.0,
        "length": 242,
        "protein_name": "Myogenic factor 6",
        "gene_name": "MYF6",
        "organism": "Human",
        "refseq_name": "myogenic factor 6",
        "refseq_ac": "NP_002460",
        "gene_names_uniprotkb": "MYF6; BHLHC4; MRF4",
        "gene_names_refseq": "CNM3; MRF4; MYF6; bHLHc4; myf-6",
        "protein_names_uniprotkb": "Myogenic factor 6; Class C basic helix-loop-helix protein 4; Muscle-specific regulatory factor 4; Myf-6; bHLHc4",
        "protein_names_refseq": "class C basic helix-loop-helix protein 4; muscle-specific regulatory factor 4; myogenic factor 6 (herculin); myogenic factor 6",
        "tax_id": 9606,
        "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17); congenital structural myopathy (Disease Ontology:DOID:422)",
        "pathway": " (hsa:4618);  (R-HSA-525793);  (R-HSA-9839394)",
        "pathway_count": 3,
        "publication_count": 24,
        "publication_id_list": "10330143;10601328;10805738;11053684;11782431;12634428;14739931;18299279;19453261;19564926;20160094;2311584;24715725;29557506;30467960;31409900;32040482;37222488;8413199;9069290;9418854;9786951;9858528;9988769",
        "class_list": "",
        "function": "Hypomethylation status of MYF6 supported expression in Hairy cell leukemia more than Hairy cell leukemia variant. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R898;Q53X80;Q6FHI9",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035914 skeletal muscle cell differentiation;GO:0007519 skeletal muscle tissue development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "P23409-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P24844-1",
        "uniprot_id": "MYL9_HUMAN",
        "mass": 19827.0,
        "length": 172,
        "protein_name": "Myosin regulatory light polypeptide 9",
        "gene_name": "MYL9",
        "organism": "Human",
        "refseq_name": "myosin regulatory light polypeptide 9 isoform a",
        "refseq_ac": "NP_006088",
        "gene_names_uniprotkb": "MYL9; MLC2; MRLC1; MYRL2",
        "gene_names_refseq": "LC20; MLC-2C; MLC2; MMIHS4; MRLC1; MYL9; MYRL2",
        "protein_names_uniprotkb": "Myosin regulatory light polypeptide 9; 20 kDa myosin light chain; LC20; MLC-2C; Myosin RLC; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 9; Myosin regulatory light chain MRLC1",
        "protein_names_refseq": "20 kDa myosin light chain; epididymis secretory sperm binding protein; myosin RLC; myosin regulatory light chain 1; myosin regulatory light chain 9; myosin regulatory light chain MRLC1; myosin regulatory light polypeptide 9 isoform a; myosin regulatory light polypeptide 9; myosin, light chain 9, regulatory; myosin, light polypeptide 9, regulatory",
        "tax_id": 9606,
        "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); megacystis-microcolon-intestinal hypoperistalsis syndrome 4 (MONDO:MONDO:0030296)",
        "pathway": " (hsa:10398);  (R-HSA-3928663);  (R-HSA-416572);  (R-HSA-445355);  (R-HSA-5625740);  (R-HSA-5625900);  (R-HSA-5627117);  (R-HSA-5627123);  (R-HSA-8936459)",
        "pathway_count": 9,
        "publication_count": 189,
        "publication_id_list": "10047984;10092231;10330186;10470034;10617663;10619026;10639334;10652353;10748018;10753910;10769020;10924361;10947843;10975528;10991994;11018042;11134534;11179879;11242081;11278486;11313932;11331307;11457814;11532985;11804587;11889009;11942626;12048254;12081505;12185584;12196628;12198493;12220504;12453877;12483298;12576332;12730235;12783890;12802051;14506282;14514689;14580336;14627618;15000491;15003508;15184667;15210733;15377279;15378014;156362;15723050;15791647;15848799;16202622;16204230;16219803;16431929;16628190;16854367;17015463;17055381;17151359;17301291;18006505;18025083;18316480;18491316;18669648;18707149;18829550;18854160;18974361;19114653;19289088;1930128;19380584;19509293;19513348;19562805;19664995;19723632;19851336;20068231;20166139;20339092;20444238;20876458;20956536;21072057;21098037;21129147;21252065;21351730;21408167;21457715;21725049;21749319;22136066;22293177;22421042;22777353;22778174;23161543;23444367;23481700;23716662;23834404;24128008;24166499;24859002;24872348;2526655;25576301;25645385;25892735;26010396;26362469;26375851;26758079;26992070;27600516;2764880;27679490;27846572;27862975;27920218;28514659;28741090;28832583;28834231;28904123;29242379;29331515;29393594;29453416;29508533;29557506;29632711;2966156;29769354;29786170;29789417;30315122;30429286;3079756;31154438;31844290;32350084;32502341;32938616;32983136;33031641;33141586;33592498;35051231;35251023;35580925;36010968;36284347;36580660;37801199;3780718;37926835;37938771;37950670;38009294;38253038;3839510;38472375;38665916;7559638;8107774;8543060;8662509;8702756;8858389;9278512;9354661;9481611;9535855;9598563;9600334;9683637;9792683;9855623;9870942;9870943;9889122;9988689",
        "class_list": "",
        "function": "LAMB3 Promotes Myofibrogenesis and Cytoskeletal Reorganization in Endometrial Stromal Cells via the RhoA/ROCK1/MYL9 Pathway., [RefSeq, PubMed]; MYL9 expressed in cancer-associated fibroblasts regulate the immune microenvironment of colorectal cancer and promotes tumor progression in an autocrine manner. Publication Status: Online-Only, [RefSeq, PubMed]; MYL9 promotes squamous cervical cancer migration and invasion by enhancing aerobic glycolysis., [RefSeq, PubMed]; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P5T6;Q9BQL9;Q9BUF9;Q9H136",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0032036 myosin heavy chain binding",
        "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0001725 stress fiber",
        "go_biological_process": "GO:0070527 platelet aggregation;GO:0006937 regulation of muscle contraction;GO:0043149 stress fiber assembly;GO:0030239 myofibril assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 19.2,
        "record_id": "P24844-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "P35580-1",
        "uniprot_id": "MYH10_HUMAN",
        "mass": 228999.0,
        "length": 1976,
        "protein_name": "Myosin-10",
        "gene_name": "MYH10",
        "organism": "Human",
        "refseq_name": "myosin-10 isoform 1",
        "refseq_ac": "NP_001242941",
        "gene_names_uniprotkb": "MYH10",
        "gene_names_refseq": "MYH10; NMMHC-IIB; NMMHCB",
        "protein_names_uniprotkb": "Myosin-10; Cellular myosin heavy chain, type B; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; NMMHC II-b; NMMHC-B; NMMHC-IIB; Non-muscle myosin heavy chain B; Non-muscle myosin heavy chain IIb",
        "protein_names_refseq": "myosin heavy chain, nonmuscle type B; myosin, heavy chain 10, non-muscle; myosin, heavy polypeptide 10, non-muscle; myosin-10 isoform 1; nonmuscle myosin II heavy chain-B; nonmuscle myosin heavy chain IIB",
        "tax_id": 9606,
        "disease": "MYH-9 related disease (Disease Ontology:DOID:0060651)",
        "pathway": " (hsa:4628);  (R-HSA-3928663);  (R-HSA-416572);  (R-HSA-5625740);  (R-HSA-5625900);  (R-HSA-5627117);  (R-HSA-5627123)",
        "pathway_count": 7,
        "publication_count": 187,
        "publication_id_list": "10047984;10092231;10330186;10470034;10619026;10639334;10652353;10748018;10753910;10769020;10924361;10975528;11018042;11134534;11179879;11237011;11278486;11313932;11331307;11804587;11942626;12185584;12196628;12198493;12220504;12453877;12730235;12783890;12802051;14514689;14580336;14654843;15000491;15003508;15184667;15210733;15378014;15791647;15848799;16202622;16204230;16219803;16431929;16611744;16721066;16854367;17074750;17081983;17151359;17301291;17525332;18006505;18025083;18318008;1860190;18669648;18675813;18829550;18991276;19289088;19513348;19608861;19690332;19723632;20052411;20068231;20220067;20305658;20444238;20603131;20682791;21098037;21351730;21406692;21749319;22293177;22480440;22544926;22869377;23161543;23186163;23301498;23444367;23481700;23716662;24128008;24166499;24275569;24366607;24715725;24859002;25003005;25356899;25428876;25576301;25645385;26154972;26375851;26853435;26992070;27600516;27846572;28345668;28489076;28832583;28834231;29242379;29351928;29393594;29493099;29508533;29557506;29632046;29632711;2966156;29786170;30315122;30429286;30524438;30620550;30779550;3079756;31020640;31844290;32157095;32265295;32350084;32357974;32387766;32502341;32897882;32938616;33091337;33141586;33214551;33298915;33392160;33592498;33691108;33968037;33981976;34019948;34171305;34229054;34357683;34405274;34725712;34738311;35008409;35051231;35138101;35154160;35251023;35561310;35580925;35980381;36010968;36215666;36241641;36284347;37217939;37938771;38019611;3839510;38517106;38665916;39048823;39990658;40596516;7499478;7559638;7782316;7916668;8107774;8543060;8662509;8690889;8702756;9278512;9354661;9535855;9683637;9792683;9870942;9870943;9889122;9988689",
        "class_list": "",
        "function": "(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B., [UniProtKB, PubMed, PubMed]; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9., [UniProtKB, PubMed, PubMed]; Down-regulation of MYH10 driven by chromosome 17p13.1 deletion promotes hepatocellular carcinoma metastasis through activation of the EGFR pathway., [RefSeq, PubMed]; Heterozygous variants in MYH10 associated with neurodevelopmental disorders and congenital anomalies with evidence for primary cilia-dependent defects in Hedgehog signaling., [RefSeq, PubMed]; Mechanisms underlying Myosin 10's contribution to the maintenance of mitotic spindle bipolarity., [RefSeq, PubMed]; Spindle cell neoplasms with novel LTK fusion - Expanding the spectrum of kinase fusion-positive soft tissue tumors., [RefSeq, PubMed]; This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RWP9;D3DTS1;F8VTL3;Q12989;Q149N3;Q149N4;Q16087;Q4LE45;Q6PK16;Q9BWG0",
        "ec_number_list": "",
        "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0043531 ADP binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0050714 positive regulation of protein secretion;GO:0030048 actin filament-based movement;GO:0031032 actomyosin structure organization;GO:0046718 symbiont entry into host cell",
        "synthesized_glycan_count": 0,
        "hit_score": 19.2,
        "record_id": "P35580-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q32MK0-3",
        "uniprot_id": "MYLK3_HUMAN",
        "mass": 88393.0,
        "length": 819,
        "protein_name": "Myosin light chain kinase 3",
        "gene_name": "MYLK3",
        "organism": "Human",
        "refseq_name": "myosin light chain kinase 3 isoform 2",
        "refseq_ac": "NP_001295230",
        "gene_names_uniprotkb": "MYLK3; MLCK",
        "gene_names_refseq": "MLCK2; MLCK; MYLK3; caMLCK",
        "protein_names_uniprotkb": "Myosin light chain kinase 3; 2.7.11.18; Cardiac-MLCK; Cardiac-MyBP-C-associated Ca/CaM kinase",
        "protein_names_refseq": "MLC kinase; cardiac-MLCK; cardiac-MyBP-C associated Ca/CaM kinase; myosin light chain kinase 3 isoform 2; putative myosin light chain kinase 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91807)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "16959974;17885681;18390750;19054851;23186163;23591626;23863751;24715725;24722904;26992070;28228285;29235529;29786170;30524438;32157095;32161166;32938616;35051231;36010968",
        "class_list": "",
        "function": "Biochemical and physiological regulation of cardiac myocyte contraction by cardiac-specific myosin light chain kinase. Review article, [RefSeq, PubMed]; Data indicate that the IL-1beta-induced increase in MLCK protein expression and Caco-2 TJ permeability was mediated by an increase in MLCK expression and activity and by an NF-kappaB-dependent increase in MLCK gene transcription, [RefSeq, PubMed]; Integrated cDNA expression analysis of failing human myocardia uncovered a novel protein kinase, cardiac-specific myosin light chain kinase (cardiac-MLCK), which acts on MLC2v., [RefSeq, PubMed]; Kinase that phosphorylates MYL2 in vitro (By similarity). Has been proposed to be calmodulin-dependent, although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin (By similarity). Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]., [RefSeq]; Study identified MYLK3 mutations associated with familial dilated cardiomyopathy. In vitro experiments and immunohistochemistry suggested that the MYLK3 mutations identified in this study result in markedly reduced levels of protein expression and myosin light chain 2 phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; These findings suggest that hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis via an MLCK and a PTEN-dependent pathway., [RefSeq, PubMed]; This study demonstrates that cyclic stretch disrupts tight junctions and adherens junctions by a JNK2, c-Src, and MLCK-dependent mechanism., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5BUL9;B7Z5U8;Q32MK1;Q96DV1",
        "ec_number_list": "2.7.11.18",
        "go_molecular_function": "GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0004687 myosin light chain kinase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton",
        "go_biological_process": "GO:0007165 signal transduction;GO:0055003 cardiac myofibril assembly;GO:1905075 positive regulation of tight junction disassembly;GO:0045214 sarcomere organization;GO:0071347 cellular response to interleukin-1",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q32MK0-3",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5H9M0-1",
        "uniprot_id": "PWP3B_HUMAN",
        "mass": 79040.0,
        "length": 696,
        "protein_name": "PWWP domain-containing DNA repair factor 3B",
        "gene_name": "PWWP3B",
        "organism": "Human",
        "refseq_name": "PWWP domain-containing DNA repair factor 3B",
        "refseq_ac": "NP_001164491",
        "gene_names_uniprotkb": "PWWP3B; MUM1L1",
        "gene_names_refseq": "MUM1L1; PWWP3B",
        "protein_names_uniprotkb": "PWWP domain-containing DNA repair factor 3B; MUM1-like protein 1; Mutated melanoma-associated antigen 1-like protein 1; PWWP domain-containing protein MUM1L1; PWWP3B",
        "protein_names_refseq": "MUM1 like 1; MUM1-like protein 1; PWWP domain-containing DNA repair factor 3B; PWWP domain-containing protein MUM1L1; melanoma associated antigen (mutated) 1-like 1; mutated melanoma-associated antigen 1-like protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:139221)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "35494241;36856181;38253038",
        "class_list": "",
        "function": "MUM1L1 as a Tumor Suppressor and Potential Biomarker in Ovarian Cancer: Evidence from Bioinformatics Analysis and Basic Experiments., [RefSeq, PubMed]; This gene encodes a protein which contains a mutated melanoma-associated antigen 1 domain. Proteins which contain mutated antigens are expressed at high levels on certain types of cancers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DUX2;Q49AS5;Q8N2C0;Q96MT6",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0070062 extracellular exosome",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q5H9M0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5VTT5-1",
        "uniprot_id": "MYOM3_HUMAN",
        "mass": 162189.0,
        "length": 1437,
        "protein_name": "Myomesin-3",
        "gene_name": "MYOM3",
        "organism": "Human",
        "refseq_name": "myomesin-3",
        "refseq_ac": "NP_689585",
        "gene_names_uniprotkb": "MYOM3",
        "gene_names_refseq": "MYOM3",
        "protein_names_uniprotkb": "Myomesin-3; Myomesin family member 3",
        "protein_names_refseq": "myomesin family, member 3; myomesin-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:127294)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "17975119;19023099;23271734;26060189;29557506;29886034;32265295;32387766;32938616;33392160;33468054;33981976;34171305;35051231;35580925",
        "class_list": "",
        "function": "An acute eccentric exercise increases circulating myomesin 3 fragments. Publication Status: Online-Only, [RefSeq, PubMed]; MYOM3 fragments hold promise for minimally invasive assessment of experimental therapies for DMD and other neuromuscular disorders., [RefSeq, PubMed]; May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle., [UniProtKB]; Mutations in Pakistani patients with dilated cardiomyopathy rs375563861 (C2orf40), rs143187236 (MYOM3), and rs564181443 (RTKN2) have 3 fold or higher allele frequency in South Asians than in the global populations, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NF75;Q5VTT6;Q6AWC0;Q6AWC1;Q6NXF9;Q6ZRG7;Q7Z3G9;Q8NA11;Q96C54",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008307 structural constituent of muscle",
        "go_cellular_component": "GO:0031430 M band",
        "go_biological_process": "GO:0045214 sarcomere organization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q5VTT5-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q5VVJ2-1",
        "uniprot_id": "MYSM1_HUMAN",
        "mass": 95032.0,
        "length": 828,
        "protein_name": "Deubiquitinase MYSM1",
        "gene_name": "MYSM1",
        "organism": "Human",
        "refseq_name": "deubiquitinase MYSM1",
        "refseq_ac": "NP_001078956",
        "gene_names_uniprotkb": "MYSM1; KIAA1915",
        "gene_names_refseq": "2A-DUB; 2ADUB; BMFS4; MYSM1",
        "protein_names_uniprotkb": "Deubiquitinase MYSM1; 2A-DUB; 3.4.19.-; Myb-like, SWIRM and MPN domain-containing protein 1",
        "protein_names_refseq": "deubiquitinase MYSM1; histone H2A deubiquitinase MYSM1; myb-like, SWIRM and MPN domain-containing protein 1",
        "tax_id": 9606,
        "disease": "diabetic retinopathy (Disease Ontology:DOID:8947); bone marrow failure syndrome 4 (MONDO:MONDO:0020856)",
        "pathway": " (hsa:114803);  (R-HSA-5689901)",
        "pathway_count": 2,
        "publication_count": 67,
        "publication_id_list": "10383417;11237011;12353037;17428495;17525332;17707232;18669648;18758443;19202061;19690332;20068231;21406692;22169041;23186163;23246432;23481700;23783831;24062447;24288411;24715725;25418920;25645385;26154972;26220525;26992070;27397612;27600516;27846572;27920218;28115216;28228285;28832583;28834231;28904123;29242379;29493099;29508533;29557506;29632711;29786170;30379171;30429286;31844290;32157095;32387766;32466590;32488085;32502341;32938616;33086059;33091337;33141586;33298915;33592498;33717175;33912179;33936100;34171305;34706761;34932366;35051231;35318648;35580925;36284347;36611064;37938771;38065233",
        "class_list": "",
        "function": "Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development. Publication Status: Online-Only, [RefSeq, PubMed]; Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors. Publication Status: Online-Only, [RefSeq, PubMed]; MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway., [RefSeq, PubMed]; MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaks., [RefSeq, PubMed]; MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; The SWIRM structure of human MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM1), is reported., [RefSeq, PubMed]; The identification of histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that helps in delineating a strategy for specific regulatory pathways of gene activation, is reported., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KA54;B3KX65;Q68DD3;Q6AI53;Q7Z3G8;Q96PX3",
        "ec_number_list": "2.3.1.48;2.3.1.-;3.4.19.-;2.3.1.57",
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding;GO:0042393 histone binding;GO:0140492 metal-dependent deubiquitinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002376 immune system process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q5VVJ2-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q6N069-1",
        "uniprot_id": "NAA16_HUMAN",
        "mass": 101462.0,
        "length": 864,
        "protein_name": "N-alpha-acetyltransferase 16, NatA auxiliary subunit",
        "gene_name": "NAA16",
        "organism": "Human",
        "refseq_name": "N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform 3",
        "refseq_ac": "NP_001104268",
        "gene_names_uniprotkb": "NAA16; NARG1L; NAT2",
        "gene_names_refseq": "NAA16; NARG1L",
        "protein_names_uniprotkb": "N-alpha-acetyltransferase 16, NatA auxiliary subunit; NARG1-like protein; NMDA receptor-regulated 1-like protein",
        "protein_names_refseq": "N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform 3; NARG1-like protein; NMDA receptor-regulated 1-like protein",
        "tax_id": 9606,
        "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); congenital heart disease (Disease Ontology:DOID:1682)",
        "pathway": " (hsa:79612)",
        "pathway_count": 1,
        "publication_count": 46,
        "publication_id_list": "19480662;19660095;19664994;24366607;24397554;25576301;26992070;27726376;27862975;28218747;28228285;28832583;28904123;29242379;29393594;29437277;29557506;29632046;29632711;30315122;30379171;30429286;30779550;31154438;31217245;31530632;31844290;31848261;32157095;32357974;32387766;32502341;32938616;32983136;33298915;33691108;33912179;33968037;33981976;34087483;34171305;34561969;35051231;35580925;36010968;36241641",
        "class_list": "",
        "function": "Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity., [UniProtKB]; HNaa16p (NARG1L) interacts with hNaa10p (hArd1) making a distinct ribosome associated human NatA N-terminal acetyltransferase complex. hNAA16 is expressed in a variety of human cell lines and specific knockdown of hNAA16 induces cell death. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0QZ59;Q5VSP9;Q6P2D5;Q8N5J3;Q8N870",
        "ec_number_list": "",
        "go_molecular_function": "GO:0043022 ribosome binding;GO:0010698 acetyltransferase activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0050821 protein stabilization;GO:0051604 protein maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q6N069-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q86VE0-1",
        "uniprot_id": "MYPOP_HUMAN",
        "mass": 42508.0,
        "length": 399,
        "protein_name": "Myb-related transcription factor, partner of profilin",
        "gene_name": "MYPOP",
        "organism": "Human",
        "refseq_name": "myb-related transcription factor, partner of profilin",
        "refseq_ac": "NP_001012661",
        "gene_names_uniprotkb": "MYPOP; P42POP",
        "gene_names_refseq": "MYPOP; P42pop",
        "protein_names_uniprotkb": "Myb-related transcription factor, partner of profilin; Myb-related protein p42POP; Partner of profilin",
        "protein_names_refseq": "myb-related protein p42POP; myb-related transcription factor, partner of profilin; p42 Myb-related transcription factor, partner of profilin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:339344)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "24366607;26154972;28832583;29242379;29557506;30379171;31092671;32157095;32387766;33298915;33968037;33981976;34171305;35051231",
        "class_list": "",
        "function": "Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q86VE0-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BRK3-1",
        "uniprot_id": "MXRA8_HUMAN",
        "mass": 49132.0,
        "length": 442,
        "protein_name": "Matrix remodeling-associated protein 8",
        "gene_name": "MXRA8",
        "organism": "Human",
        "refseq_name": "matrix remodeling-associated protein 8 isoform 2 precursor",
        "refseq_ac": "NP_001269511",
        "gene_names_uniprotkb": "MXRA8",
        "gene_names_refseq": "ASP3; MXRA8",
        "protein_names_uniprotkb": "Matrix remodeling-associated protein 8; Limitrin",
        "protein_names_refseq": "limitrin; matrix remodeling-associated protein 8 isoform 2 precursor; matrix-remodeling-associated protein 8; matrix-remodelling associated 8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54587);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 3,
        "publication_count": 99,
        "publication_id_list": "10.1101/2023.09.13.557529;10026136;10077652;10218588;10512690;10614670;10681634;10810289;10898936;10912521;10951195;10990447;11158056;11250653;11264294;11316783;11522292;11606061;11739083;11751371;11788658;12241545;12379487;12466191;12810533;12904166;1370451;1383255;14603461;15126567;15308688;15469690;15485880;15525596;15642270;17047378;17249697;17312271;17985932;18083107;22492581;23386276;24190977;2476804;2479552;25576301;26091039;26992070;27397612;27726376;27846572;27862975;29242379;29557506;29769725;29786170;29789417;30429286;30459171;31080061;31080063;31154438;31844290;31848261;32157095;32350084;32387766;32938616;33592498;33968037;35051231;35251023;35456497;35580925;36284347;37762032;37938771;38441550;38665916;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;8781553;8817670;8894645;8964575;9497324;9709957;9733769;9786878;9922210",
        "class_list": "",
        "function": "(Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses., [UniProtKB, PubMed, PubMed]; Elevated Expression of miR-200c/141 in MDA-MB-231 Cells Suppresses MXRA8 Levels and Impairs Breast Cancer Growth and Metastasis In Vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Exogenous expression of DICAM in human umbilical vein endothelial cells suppressed angiogenesis in vitro Matrigel and in vivo plug assays, and conversely, DICAM knockdown enhanced angiogenesis, [RefSeq, PubMed]; Loss of MXRA8 Delays Mammary Tumor Development and Impairs Metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; New member of the transmembrane-type immunoglobulin superfamily and designated limitrin, localizing selectively to glia limitans in mouse brain, [RefSeq, PubMed]; Single-cell RNA combined with bulk RNA analysis to explore oxidative stress and energy metabolism factors and found a new prostate cancer oncogene MXRA8., [RefSeq, PubMed]; Studies provide insight into how Mxra8 binds CHIKV and creates a path for developing alphavirus entry inhibitors., [RefSeq, PubMed]; The stalk region of MXRA8 is critical for CHIKV virus entry., [RefSeq, PubMed]; Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:22492581, PubMed:23386276). Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By similarity). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed:23386276). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed:23386276). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed:23386276). May play a role in the maturation and maintenance of the blood-brain barrier (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KTR6;B4DE34;Q5TA39;Q96KC3",
        "ec_number_list": "",
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005788 endoplasmic reticulum lumen;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0060857 establishment of glial blood-brain barrier",
        "synthesized_glycan_count": 0,
        "hit_score": 10.6,
        "record_id": "Q9BRK3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9BUA6-1",
        "uniprot_id": "MYL10_HUMAN",
        "mass": 25308.0,
        "length": 226,
        "protein_name": "Myosin regulatory light chain 10",
        "gene_name": "MYL10",
        "organism": "Human",
        "refseq_name": "myosin regulatory light chain 10",
        "refseq_ac": "NP_612412",
        "gene_names_uniprotkb": "MYL10; MYLC2PL; PLRLC",
        "gene_names_refseq": "MYL10; MYLC2PL; PLRLC",
        "protein_names_uniprotkb": "Myosin regulatory light chain 10; Myosin light chain 2, lymphocyte-specific; Precursor lymphocyte-specific regulatory light chain",
        "protein_names_refseq": "myosin light chain 2, lymphocyte-specific; myosin light chain 2, precursor lymphocyte-specific; myosin regulatory light chain 10; myosin, light chain 10, regulatory; precursor lymphocyte-specific regulatory light chain",
        "tax_id": 9606,
        "disease": "hypertrophic cardiomyopathy 10 (Disease Ontology:DOID:0110316)",
        "pathway": " (hsa:93408);  (R-HSA-445355)",
        "pathway_count": 2,
        "publication_count": 46,
        "publication_id_list": "10991994;11237011;11242081;11457814;11532985;11889009;12048254;14506282;14627618;15377279;156362;17055381;18974361;1930128;19380584;20877624;22421042;22778174;23555621;23834404;24397554;24872348;2526655;26362469;26375851;26992070;2764880;27679490;28741090;29557506;30524438;31530632;31844290;32897882;32938616;33298915;33968037;34509645;35051231;36010968;3780718;8858389;9481611;9598563;9600334;9855623",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q9BUA6-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9UKX3-1",
        "uniprot_id": "MYH13_HUMAN",
        "mass": 223605.0,
        "length": 1938,
        "protein_name": "Myosin-13",
        "gene_name": "MYH13",
        "organism": "Human",
        "refseq_name": "myosin-13",
        "refseq_ac": "NP_003793",
        "gene_names_uniprotkb": "MYH13",
        "gene_names_refseq": "MYH13; MyHC-IIL; MyHC-eo",
        "protein_names_uniprotkb": "Myosin-13; MyHC-EO; MyHC-IIL; Myosin heavy chain 13; Myosin heavy chain, skeletal muscle, extraocular; Myosin heavy chain, skeletal muscle, laryngeal; Superfast myosin",
        "protein_names_refseq": "extraocular muscle myosin heavy chain; extraocular myosin heavy chain; myosin heavy chain, skeletal muscle, extraocular; myosin heavy chain, skeletal muscle, laryngeal; myosin, heavy chain 13, skeletal muscle; myosin, heavy polypeptide 13, skeletal muscle; myosin-13; superfast myosin",
        "tax_id": 9606,
        "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)",
        "pathway": " (hsa:8735)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "10388558;11032345;12110653;18452278;18830724;19240061;21426302;23908353;24715725;26992070;27862975;29557506;31154438;31217245;31844290;32387766;33968037;35051231;38160435;39531497;9806854",
        "class_list": "",
        "function": "Domain-mapping experiments indicated that muscle-type creatine kinase binds to the C-terminal domains of MyBPC1, which is also the binding site of myosin., [RefSeq, PubMed]; Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles., [UniProtKB, PubMed]; MYH13, a superfast myosin expressed in extraocular, laryngeal and syringeal muscles., [RefSeq, PubMed]; Meta-analysis of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Phylogenic imlications in extraocular muscles (REVIEW), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 62,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 15,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95252;Q9P0U8",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity",
        "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0070062 extracellular exosome;GO:0032982 myosin filament;GO:0030016 myofibril",
        "go_biological_process": "GO:0006936 muscle contraction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q9UKX3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y2K3-1",
        "uniprot_id": "MYH15_HUMAN",
        "mass": 222162.0,
        "length": 1926,
        "protein_name": "Myosin-15",
        "gene_name": "MYH15",
        "organism": "Human",
        "refseq_name": "myosin-15",
        "refseq_ac": "NP_055796",
        "gene_names_uniprotkb": "MYH15; KIAA1000",
        "gene_names_refseq": "MYH15",
        "protein_names_uniprotkb": "Myosin-15; Myosin heavy chain 15",
        "protein_names_refseq": "myosin, heavy polypeptide 15; myosin-15",
        "tax_id": 9606,
        "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)",
        "pathway": " (hsa:22989)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;11919279;17975119;18073581;22360420;25418920;28005267;28832583;29242379;30906771;30985904",
        "class_list": "",
        "function": "A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration., [RefSeq, PubMed]; MYH15 expression is significantly downregulated in human masticatory mucosa during wound healing, [RefSeq, PubMed]; Muscle contraction., [UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Rare variants in MYH15 represent a likely genetic risk factor for amyotrophic lateral sclerosis. Furthermore, MYH15 could modulate the toxicity of dipeptides produced from expanded G4C2 repeat., [RefSeq, PubMed]; This is the first study to report the association of MYH15 gene polymorphisms with asthma. Polymorphisms of rs9288876, rs7635009, and rs1454197 altered transcriptional regulation of MYH15 and may be functional variants conferring susceptibility to asthma Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 16,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003774 cytoskeletal motor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0032982 myosin filament;GO:0030016 myofibril;GO:0016460 myosin II complex;GO:0016459 myosin complex",
        "go_biological_process": "GO:0002074 extraocular skeletal muscle development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9Y2K3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "Q9Y623-1",
        "uniprot_id": "MYH4_HUMAN",
        "mass": 223071.0,
        "length": 1939,
        "protein_name": "Myosin-4",
        "gene_name": "MYH4",
        "organism": "Human",
        "refseq_name": "myosin-4",
        "refseq_ac": "NP_060003",
        "gene_names_uniprotkb": "MYH4",
        "gene_names_refseq": "MYH2B; MYH4; MyHC-2B; MyHC-IIb",
        "protein_names_uniprotkb": "Myosin-4; MyHC-2b; MyHC-IIb; Myosin heavy chain 2b; Myosin heavy chain 4; Myosin heavy chain IIb; Myosin heavy chain, skeletal muscle, fetal",
        "protein_names_refseq": "myosin heavy chain 2b; myosin heavy chain IIb; myosin heavy chain, skeletal muscle, fetal; myosin, heavy chain 4, skeletal muscle; myosin, heavy polypeptide 4, skeletal muscle; myosin-4",
        "tax_id": 9606,
        "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); sciatic neuropathy (Disease Ontology:DOID:11446); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)",
        "pathway": " (hsa:4622)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "10388558;18669648;20068231;21102503;23796659;25576301;26059207;26992070;28904123;29557506;31154438;31530632;32387766;35051231;37217939",
        "class_list": "",
        "function": "Muscle contraction., [UniProtKB]; MyHC-2b was always co-expressed with the major MyHC isoforms, not only with the fast ones (MyHC-2a and -2x) but with the slow isoform (MyHC-1) as well., [RefSeq, PubMed]; NMMII and actin isoform expression changes coordinately with the remodeling phase of repair, and NMMII is increased as matrix stiffness increases. As NMMII expression increases, so does the fibroblast contractility., [RefSeq, PubMed]; Transcriptional levels of MHC-I, MHC-IIa, and MHC-IIb in denervation groups were significantly down-regulated compared with controls, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 49,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 38,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 16,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0003725 double-stranded RNA binding",
        "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0030017 sarcomere;GO:0032982 myosin filament;GO:0030016 myofibril",
        "go_biological_process": "GO:0006936 muscle contraction;GO:0030049 muscle filament sliding;GO:0030048 actin filament-based movement;GO:0046034 ATP metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q9Y623-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6NI72-1",
        "uniprot_id": "NCF1B_HUMAN",
        "mass": 44817.0,
        "length": 391,
        "protein_name": "Putative neutrophil cytosol factor 1B",
        "gene_name": "NCF1B",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": "",
        "gene_names_uniprotkb": "NCF1B; SH3PXD1B",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative neutrophil cytosol factor 1B; NCF-1B; Putative SH3 and PX domain-containing protein 1B",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "chronic granulomatous disease (Disease Ontology:DOID:3265); rheumatoid arthritis (Disease Ontology:DOID:7148)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 24,
        "publication_id_list": "23481700;24366607;25418920;26154972;26375851;26758079;26929215;27846572;28411811;28510447;29242379;29437277;29493099;29557506;30429286;31154438;31530632;31844290;31848261;32350084;32357974;32387766;32561536;33123756",
        "class_list": "",
        "function": "May be required for activation of the latent NADPH oxidase (necessary for superoxide production)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_n_glycosites": 0,
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        "reported_mutagensis": 0,
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        "missing_score": 0,
        "biomarker_type": "",
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        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0016176 superoxide-generating NADPH oxidase activator activity",
        "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045730 respiratory burst;GO:0042554 superoxide anion generation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "A6NI72-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "A6PVI3-1",
        "uniprot_id": "NCB2L_HUMAN",
        "mass": 17685.0,
        "length": 153,
        "protein_name": "Nuclear cap-binding protein subunit 2-like",
        "gene_name": "NCBP2L",
        "organism": "Human",
        "refseq_name": "nuclear cap-binding protein subunit 2-like",
        "refseq_ac": "NP_001335301",
        "gene_names_uniprotkb": "NCBP2L",
        "gene_names_refseq": "NCBP2L; dJ820B18.1",
        "protein_names_uniprotkb": "Nuclear cap-binding protein subunit 2-like",
        "protein_names_refseq": "nuclear cap-binding protein subunit 2-like",
        "tax_id": 9606,
        "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)",
        "pathway": " (hsa:392517)",
        "pathway_count": 1,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0000339 RNA cap binding",
        "go_cellular_component": "GO:0005846 nuclear cap binding complex",
        "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A6PVI3-1",
        "record_type": "protein"
    },
    {
        "uniprot_canonical_ac": "O75380-1",
        "uniprot_id": "NDUS6_HUMAN",
        "mass": 13712.0,
        "length": 124,
        "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial",
        "gene_name": "NDUFS6",
        "organism": "Human",
        "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor",
        "refseq_ac": "NP_004544",
        "gene_names_uniprotkb": "NDUFS6",
        "gene_names_refseq": "CI-13kA; CI-13kD-A; CI13KDA; MC1DN9; NDUFS6",
        "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; CI-13kD-A; Complex I-13kD-A; NADH-ubiquinone oxidoreductase 13 kDa-A subunit",
        "protein_names_refseq": "NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; NADH-ubiquinone oxidoreductase 13 kDa-A subunit; NADH:ubiquinone oxidoreductase NDUFS6 subunit; complex I 13kDa subunit A; complex I, mitochondrial respiratory chain, 13-kD subunit",
        "tax_id": 9606,
        "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 9 (Disease Ontology:DOID:0112073); arteriosclerosis (Disease Ontology:DOID:2349); cervical cancer (Disease Ontology:DOID:4362)",
        "pathway": " (hsa:4726);  (R-HSA-611105);  (R-HSA-6799198)",
        "pathway_count": 3,
        "publication_count": 81,
        "publication_id_list": "10327278;11220739;11237011;11695836;12231006;12611891;12837546;1327877;14741580;15250827;15372108;16230336;17033964;17936786;186667;19259137;19752196;20406883;20552642;20858599;21924235;23150584;23270816;23553477;23564345;23747254;239860;24191001;24715725;25564869;25576301;25678554;26375851;26992070;27452731;27499296;27600516;27626371;27846572;28063628;28218747;28832583;28834231;29242379;29393594;29437277;29557506;29632046;29786170;30192525;30315122;30379171;30429286;31666358;31844290;31848261;31866046;32157095;32265295;32320651;32387766;33097395;33141586;33323934;33879611;33882309;33936100;33968037;34561969;35333655;35561310;35614220;36215666;37558663;38199007;38459834;38665916;4288886;9571201;9647766;9878551",
        "class_list": "",
        "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]; Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6. Publication Status: Online-Only, [RefSeq, PubMed]; Alternative splicing expands the clinical spectrum of NDUFS6-related mitochondrial disorders., [RefSeq, PubMed]; Biallelic variants in two complex I genes cause abnormal splicing defects in probands with mild Leigh syndrome., [RefSeq, PubMed]; NDUFS6, a complex I subunit gene not previously associated with complex I deficiency, was grossly underexpressed in t patient cell lines., [RefSeq, PubMed]; PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.[provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": "",
        "go_molecular_function": "GO:0009055 electron transfer activity;GO:0008137 NADH dehydrogenase (ubiquinone) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I",
        "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "O75380-1",
        "record_type": "protein"
    }
]