[ { "uniprot_canonical_ac": "A0ABZ3NNP9-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NNP9", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNP9" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 862, "chemical_mass": 97032.0, "gene_names": "Lztr1;Lztr1", "protein_name": "Leucine-zipper-like transcriptional regulator 1", "disease": [ { "disease_id": "DOID:0060580", "name": "Noonan syndrome 2", "description": "A Noonan syndrome characterized by hypertrophic obstructive cardiomyopathy and that has_material_basis_in homozygous or compound heterozygous mutation in the LZTR1 gene on chromosome 22q11.", "url": "https://disease-ontology.org/term/DOID:0060580", "evidence": [ { "id": "0060580", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060580" } ], "weight": 0.0 }, { "disease_id": "DOID:0060588", "name": "Noonan syndrome 10", "description": "A Noonan syndrome that has_material_basis_in heterozygous mutation in the LZTR1 gene on chromosome 22q11.", "url": "https://disease-ontology.org/term/DOID:0060588", "evidence": [ { "id": "0060588", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060588" } ], "weight": 0.0 }, { "disease_id": "DOID:0070481", "name": "schwannomatosis 2", "description": "A schwannomatosis that has_material_basis_in germline heterozygous mutation in the LZTR1 gene on chromosome 22q11.2.", "url": "https://disease-ontology.org/term/DOID:0070481", "evidence": [ { "id": "0070481", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070481" } ], "weight": 0.0 }, { "disease_id": "DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach.", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ], "weight": 0.0 }, { "disease_id": "DOID:11984", "name": "hypertrophic cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause.", "url": "https://disease-ontology.org/term/DOID:11984", "evidence": [ { "id": "11984", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11984" } ], "weight": 0.0 }, { "disease_id": "DOID:3068", "name": "glioblastoma", "description": "A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.", "url": "https://disease-ontology.org/term/DOID:3068", "evidence": [ { "id": "3068", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3068" } ], "weight": 0.0 }, { "disease_id": "DOID:3192", "name": "neurilemmoma", "description": "A neuroma that is characterized as a benign nerve sheath tumor that is composed of Schwann cells.", "url": "https://disease-ontology.org/term/DOID:3192", "evidence": [ { "id": "3192", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3192" } ], "weight": 0.0 }, { "disease_id": "DOID:3204", "name": "schwannomatosis", "description": "A RASopathy characterized by the development of schwannomas or hybrid nerve sheath tumors.", "url": "https://disease-ontology.org/term/DOID:3204", "evidence": [ { "id": "3204", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3204" } ], "weight": 0.0 }, { "disease_id": "DOID:3490", "name": "Noonan syndrome", "description": "A RASopathy that is characterized by mildly unusual facial features, short stature, heart defects, bleeding problems, skeletal malformations, and many other signs and symptoms.", "url": "https://disease-ontology.org/term/DOID:3490", "evidence": [ { "id": "3490", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3490" } ], "weight": 0.0 }, { "disease_id": "DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", "url": "https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ], "weight": 0.0 } ], "biological_process": [ { "name": "negative regulation of Ras protein signal transduction", "id": "GO:0046580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046580", "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NNP9", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNP9" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NNP9", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNP9" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NNP9", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNP9" } ], "pmid": "" } ], "cellular_component": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NNP9", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNP9" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NNP9", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNP9" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NNP9", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNP9" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NNP9", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNP9" } ], "pmid": "" } ], "molecular_function": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NNP9", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNP9" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NNP9", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNP9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "A0ABZ3NNP9-1", "start_pos": "8", "end_pos": "8", "site_lbl": "Thr8", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 8, "start_aa": "Thr", "end_pos": 8, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr8", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ] } ] } ], "record_id": "batch.rat.22" }, { "uniprot_canonical_ac": "A0ABK0M8C9-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M8C9", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M8C9" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 166, "chemical_mass": 18911.0, "gene_names": "Trappc2l", "protein_name": "Trafficking protein particle complex subunit", "disease": [], "cellular_component": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M8C9", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M8C9" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M8C9", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M8C9" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M8C9", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M8C9" } ], "pmid": "" }, { "name": "TRAPP complex", "id": "GO:0030008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030008", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M8C9", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M8C9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M8C9", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M8C9" } ], "pmid": "" } ], "biological_process": [ { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M8C9", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M8C9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.22" }, { "uniprot_canonical_ac": "A0ABZ3NN98-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NN98", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NN98" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 389, "chemical_mass": 43884.0, "gene_names": "Doc2g;Doc2gp;Doc2g", "protein_name": "Double C2-like domain-containing protein", "disease": [ { "disease_id": "DOID:0050700", "name": "cardiomyopathy", "description": "A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle.", "url": "https://disease-ontology.org/term/DOID:0050700", "evidence": [ { "id": "0050700", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050700" } ], "weight": 0.0 }, { "disease_id": "DOID:0070515", "name": "chromosome 16p11.2 deletion syndrome, 593-kb", "description": "A chromosomal deletion syndrome characterized by language delay and mild intellectual disability that has_material_basis_in partial deletion of a contiguous 593-kb region of chromosome 16p11.2 (chr16:29.5-30.1 Mb).", "url": "https://disease-ontology.org/term/DOID:0070515", "evidence": [ { "id": "0070515", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0070515" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NN98", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NN98" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NN98", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NN98" } ], "pmid": "" } ], "molecular_function": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NN98", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NN98" } ], "pmid": "" } ], "biological_process": [ { "name": "neurotransmitter secretion", "id": "GO:0007269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007269", "evidence": [ { "database": "UniProtKB", "id": "A0ABZ3NN98", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NN98" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.22" }, { "uniprot_canonical_ac": "A0ABK0M9J5-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M9J5", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M9J5" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 523, "chemical_mass": 58815.0, "gene_names": "Rora;Rora", "protein_name": "", "disease": [ { "disease_id": "DOID:0050156", "name": "idiopathic pulmonary fibrosis", "description": "A pulmonary fibrosis that is characterized by scarring of the lung characterized by stiffness in the lungs and makes it difficult to breathe.", "url": "https://disease-ontology.org/term/DOID:0050156", "evidence": [ { "id": "0050156", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050156" } ], "weight": 0.0 }, { "disease_id": "DOID:0080815", "name": "childhood-onset asthma", "description": "A chronic asthma that is characterized by first presentation in early childhood.", "url": "https://disease-ontology.org/term/DOID:0080815", "evidence": [ { "id": "0080815", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080815" } ], "weight": 0.0 }, { "disease_id": "DOID:0080826", "name": "nocturnal asthma", "description": "A chronic asthma that is characterized by significant decline in pulmonary function and increase of airway inflammation at night. During sleep, recumbent posture causes a reduction in the lung volumes, respiratory muscle tone, and lung compliance. The overnight physiological abnormalities include: increased airway inflammation and decreased steroid responsiveness, increased pulmonary capillary blood volume, functional differences in blood/air volume ratios and mechanical coupling of the parenchyma to the airways.", "url": "https://disease-ontology.org/term/DOID:0080826", "evidence": [ { "id": "0080826", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080826" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3393", "name": "coronary artery disease", "description": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.", "url": "https://disease-ontology.org/term/DOID:3393", "evidence": [ { "id": "3393", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3393" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:399", "name": "tuberculosis", "description": "A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.", "url": "https://disease-ontology.org/term/DOID:399", "evidence": [ { "id": "399", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:399" } ], "weight": 0.0 }, { "disease_id": "DOID:4481", "name": "allergic rhinitis", "description": "A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.", "url": "https://disease-ontology.org/term/DOID:4481", "evidence": [ { "id": "4481", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4481" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:9408", "name": "acute myocardial infarction", "description": "", "url": "https://disease-ontology.org/term/DOID:9408", "evidence": [ { "id": "9408", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9408" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M9J5", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M9J5" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M9J5", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M9J5" } ], "pmid": "" } ], "biological_process": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M9J5", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M9J5" } ], "pmid": "" }, { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M9J5", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M9J5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M9J5", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M9J5" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M9J5", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M9J5" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M9J5", "url": "https://www.uniprot.org/uniprotkb/A0ABK0M9J5" } ], "pmid": "" }, { "name": "positive regulation of vascular endothelial growth factor production", "id": "GO:0010575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010575", "evidence": [ { "database": "UniProtKB", "id": "A0ABK0M9J5", "url": 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monocyte chemotaxis", "id": "GO:0090026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090026", "evidence": [ { "database": "UniProtKB", "id": "A6I4C9", "url": "https://www.uniprot.org/uniprotkb/A6I4C9" } ], "pmid": "" }, { "name": "calcium ion transport", "id": "GO:0006816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006816", "evidence": [ { "database": "UniProtKB", "id": "A6I4C9", "url": "https://www.uniprot.org/uniprotkb/A6I4C9" } ], "pmid": "" }, { "name": "intracellular calcium ion homeostasis", "id": "GO:0006874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006874", "evidence": [ { "database": "UniProtKB", "id": "A6I4C9", "url": "https://www.uniprot.org/uniprotkb/A6I4C9" } ], "pmid": "" }, { "name": "positive regulation of inflammatory response", "id": "GO:0050729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050729", "evidence": [ { "database": "UniProtKB", "id": "A6I4C9", "url": "https://www.uniprot.org/uniprotkb/A6I4C9" } ], "pmid": "" }, { "name": "cellular 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{ "name": "monocyte chemotaxis", "id": "GO:0002548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002548", "evidence": [ { "database": "UniProtKB", "id": "A6I4C9", "url": "https://www.uniprot.org/uniprotkb/A6I4C9" } ], "pmid": "" }, { "name": "cerebellum development", "id": "GO:0021549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021549", "evidence": [ { "database": "UniProtKB", "id": "A6I4C9", "url": "https://www.uniprot.org/uniprotkb/A6I4C9" } ], "pmid": "" }, { "name": "negative regulation of bone mineralization", "id": "GO:0030502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030502", "evidence": [ { "database": "UniProtKB", "id": "A6I4C9", "url": "https://www.uniprot.org/uniprotkb/A6I4C9" } ], "pmid": "" }, { "name": "positive regulation of osteoclast differentiation", "id": "GO:0045672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045672", "evidence": [ { "database": "UniProtKB", "id": "A6I4C9", "url": "https://www.uniprot.org/uniprotkb/A6I4C9" } ], "pmid": "" }, { 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"database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" }, { "name": "regulation of cell adhesion", "id": "GO:0030155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030155", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" }, { "name": "protein autophosphorylation", "id": "GO:0046777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046777", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" }, { "name": "endothelial cell migration", "id": "GO:0043542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043542", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" }, { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" }, { "name": "peptidyl-serine phosphorylation", "id": "GO:0018105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018105", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" }, { "name": "endothelial cell proliferation", "id": "GO:0001935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001935", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" }, { "name": "cell-substrate adhesion", "id": "GO:0031589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031589", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" }, { "name": "myeloid cell differentiation", "id": "GO:0030099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030099", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" } ], "molecular_function": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" }, { "name": "cAMP-dependent protein kinase activity", "id": "GO:0004691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004691", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K247", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K247" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.22" }, { "uniprot_canonical_ac": "F7EMD0-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 306, "chemical_mass": 33545.0, "gene_names": "C1qtnf3", "protein_name": "Complement C1q tumor necrosis factor-related protein 3", "disease": [], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" } ], "biological_process": [ { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "negative regulation of interleukin-6 production", "id": "GO:0032715", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032715", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "negative regulation of inflammatory response", "id": "GO:0050728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "positive regulation of cytokine production", "id": "GO:0001819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001819", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "fat cell differentiation", "id": "GO:0045444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045444", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "negative regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901223", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "negative regulation of monocyte chemotactic protein-1 production", "id": "GO:0071638", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071638", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "negative regulation of gluconeogenesis", "id": "GO:0045721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045721", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "intracellular triglyceride homeostasis", "id": "GO:0035356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035356", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" }, { "name": "positive regulation of adiponectin secretion", "id": "GO:0070165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070165", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" } ], "molecular_function": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F7EMD0", "url": "https://www.uniprot.org/uniprotkb/F7EMD0" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.22" }, { "uniprot_canonical_ac": "F7F7P3-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 146, "chemical_mass": 16241.0, "gene_names": "Ang2", "protein_name": "", "disease": [ { "disease_id": "DOID:0050589", "name": "inflammatory bowel disease", "description": "An intestinal disease characterized by inflammation located in all parts of digestive tract.", "url": "https://disease-ontology.org/term/DOID:0050589", "evidence": [ { "id": "0050589", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050589" } ], "weight": 0.0 }, { "disease_id": "DOID:0060074", "name": "ductal carcinoma in situ", "description": "A breast carcinoma in situ that is characterized by being non-invasive, not having spread outside of the duct into the surrounding breast tissue, has_material_basis_in abnormally proliferating cells, derives_from epithelial cells.", "url": "https://disease-ontology.org/term/DOID:0060074", "evidence": [ { "id": "0060074", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060074" } ], "weight": 0.0 }, { "disease_id": "DOID:0060200", "name": "amyotrophic lateral sclerosis type 9", "description": "An amyotrophic lateral sclerosis that has_material_basis_in mutation in the ANG gene on chromosome 14.", "url": "https://disease-ontology.org/term/DOID:0060200", "evidence": [ { "id": "0060200", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060200" } ], "weight": 0.0 }, { "disease_id": "DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate.", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ], "weight": 0.0 }, { "disease_id": "DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.", "url": "https://disease-ontology.org/term/DOID:10652", "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ], "weight": 0.0 }, { "disease_id": "DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder.", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ], "weight": 0.0 }, { "disease_id": "DOID:1380", "name": "endometrial cancer", "description": "A uterine cancer that is located_in tissues lining the uterus.", "url": "https://disease-ontology.org/term/DOID:1380", "evidence": [ { "id": "1380", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1380" } ], "weight": 0.0 }, { "disease_id": "DOID:13922", "name": "eosinophilic esophagitis", "description": "An esophagitis characterized by inflammation involving eosinophils located_in esophagus.", "url": "https://disease-ontology.org/term/DOID:13922", "evidence": [ { "id": "13922", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13922" } ], "weight": 0.0 }, { "disease_id": "DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.", "url": "https://disease-ontology.org/term/DOID:14330", "evidence": [ { "id": "14330", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14330" } ], "weight": 0.0 }, { "disease_id": "DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas.", "url": "https://disease-ontology.org/term/DOID:1793", "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ], "weight": 0.0 }, { "disease_id": "DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary.", "url": "https://disease-ontology.org/term/DOID:2394", "evidence": [ { "id": "2394", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:289", "name": "endometriosis", "description": "A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.", "url": "https://disease-ontology.org/term/DOID:289", "evidence": [ { "id": "289", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:289" } ], "weight": 0.0 }, { "disease_id": "DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:332", "name": "amyotrophic lateral sclerosis", "description": "A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.", "url": "https://disease-ontology.org/term/DOID:332", "evidence": [ { "id": "332", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:332" } ], "weight": 0.0 }, { "disease_id": "DOID:3526", "name": "cerebral infarction", "description": "A cerebrovascular disease that is characterized by an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain.", "url": "https://disease-ontology.org/term/DOID:3526", "evidence": [ { "id": "3526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3526" } ], "weight": 0.0 }, { "disease_id": "DOID:4085", "name": "trophoblastic neoplasm", "description": "A germ cell and embryonal cancer that derives_from trophoblastic tissue.", "url": "https://disease-ontology.org/term/DOID:4085", "evidence": [ { "id": "4085", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4085" } ], "weight": 0.0 }, { "disease_id": "DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix.", "url": "https://disease-ontology.org/term/DOID:4362", "evidence": [ { "id": "4362", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4362" } ], "weight": 0.0 }, { "disease_id": "DOID:4450", "name": "renal cell carcinoma", "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney.", "url": "https://disease-ontology.org/term/DOID:4450", "evidence": [ { "id": "4450", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4450" } ], "weight": 0.0 }, { "disease_id": "DOID:4483", "name": "rhinitis", "description": "A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.", "url": "https://disease-ontology.org/term/DOID:4483", "evidence": [ { "id": "4483", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4483" } ], "weight": 0.0 }, { "disease_id": "DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia.", "url": "https://disease-ontology.org/term/DOID:5844", "evidence": [ { "id": "5844", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ], "weight": 0.0 }, { "disease_id": "DOID:7148", "name": "rheumatoid arthritis", "description": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.", "url": "https://disease-ontology.org/term/DOID:7148", "evidence": [ { "id": "7148", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7148" } ], "weight": 0.0 }, { "disease_id": "DOID:8947", "name": "diabetic retinopathy", "description": "", "url": "https://disease-ontology.org/term/DOID:8947", "evidence": [ { "id": "8947", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8947" } ], "weight": 0.0 } ], "biological_process": [ { "name": "positive regulation of protein phosphorylation", "id": "GO:0001934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001934", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" }, { "name": "protein phosphorylation", "id": "GO:0006468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" }, { "name": "cellular response to glucose stimulus", "id": "GO:0071333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071333", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" }, { "name": "cardiac muscle hypertrophy", "id": "GO:0003300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003300", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" }, { "name": "angiotensin-activated signaling pathway", "id": "GO:0038166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038166", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" }, { "name": "cell growth involved in cardiac muscle cell development", "id": "GO:0061049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061049", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" }, { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" }, { "name": "renal absorption", "id": "GO:0070293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070293", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" }, { "name": "gene expression", "id": "GO:0010467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" } ], "molecular_function": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" }, { "name": "endonuclease activity", "id": "GO:0004519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004519", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" }, { "name": "RNA nuclease activity", "id": "GO:0004540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004540", "evidence": [ { "database": "UniProtKB", "id": "F7F7P3", "url": "https://www.uniprot.org/uniprotkb/F7F7P3" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "F7F7P3-1", "start_pos": "19", "end_pos": "19", "site_lbl": "Thr19", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 19, "start_aa": "Thr", "end_pos": 19, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr19", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ] } ] } ], "record_id": "batch.rat.22" }, { "uniprot_canonical_ac": "P0DY58-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P0DY58", "url": "https://www.uniprot.org/uniprotkb/P0DY58" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 117, "chemical_mass": 12965.0, "gene_names": "Rasal2-as1;Psr", "protein_name": "Putative protein encoded by LncRNA PSR", "disease": [], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P0DY58", "url": "https://www.uniprot.org/uniprotkb/P0DY58" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.22" }, { "uniprot_canonical_ac": "A0ACD6B5B5-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0ACD6B5B5", "url": "https://www.uniprot.org/uniprotkb/A0ACD6B5B5" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 666, "chemical_mass": 74338.0, "gene_names": "Selenoo;Selo", "protein_name": "Selenoprotein O", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.22" }, { "uniprot_canonical_ac": "A0A8I6AK43-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AK43", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AK43" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 293, "chemical_mass": 33654.0, "gene_names": "Ppa2", "protein_name": "inorganic diphosphatase", "disease": [], "biological_process": [ { "name": "diphosphate metabolic process", "id": "GO:0071344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071344", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AK43", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AK43" } ], "pmid": "" }, { "name": "regulation of mitochondrial membrane potential", "id": "GO:0051881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051881", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AK43", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AK43" } ], "pmid": "" }, { "name": "phosphate-containing compound metabolic process", "id": "GO:0006796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006796", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AK43", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AK43" } ], "pmid": "" } ], "molecular_function": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AK43", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AK43" } ], "pmid": "" }, { "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AK43", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AK43" } ], "pmid": "" }, { "name": "inorganic diphosphate phosphatase activity", "id": "GO:0004427", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004427", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AK43", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AK43" } ], "pmid": "" } ], "cellular_component": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AK43", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AK43" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AK43", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AK43" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A8I5ZVP7-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZVP7", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZVP7" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 205, "chemical_mass": 23232.0, "gene_names": "Tvp23b;Fam18b2", "protein_name": "Golgi apparatus membrane protein TVP23 homolog", "disease": [], "cellular_component": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZVP7", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZVP7" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZVP7", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZVP7" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZVP7", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZVP7" } ], "pmid": "" } ], "biological_process": [ { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZVP7", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZVP7" } ], "pmid": "" }, { "name": "protein secretion", "id": "GO:0009306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009306", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZVP7", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZVP7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "P48450-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P48450", "url": "https://www.uniprot.org/uniprotkb/P48450" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 733, "chemical_mass": 83301.0, "gene_names": "Lss;Spatc1l;Lss;Osc;Spatc1l", "protein_name": "Lanosterol synthase", "disease": [ { "disease_id": "DOID:0080582", "name": "hypotrichosis 14", "description": "A hypotrichosis that is characterized by sparse to absent lanugo-like scalp hair, sparse and brittle eyebrows, and sparse eyelashes and body hair and that has_material_basis_in homozygous or compound heterozygous mutation in the LSS gene on chromosome 21q22.", "url": "https://disease-ontology.org/term/DOID:0080582", "evidence": [ { "id": "0080582", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080582" } ], "weight": 0.0 }, { "disease_id": "DOID:0080950", "name": "alopecia-mental retardation syndrome 4", "description": "An alopecia-mental retardation syndrome that has_material_basis_in homozygous or compound heterozygous mutation in the LSS gene on chromosome 21q22.", "url": "https://disease-ontology.org/term/DOID:0080950", "evidence": [ { "id": "0080950", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080950" } ], "weight": 0.0 }, { "disease_id": "DOID:0110267", "name": "cataract 44", "description": "A cataract that has_material_basis_in homozygous mutation in the LSS gene on chromosome 21q22.", "url": "https://disease-ontology.org/term/DOID:0110267", "evidence": [ { "id": "0110267", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110267" } ], "weight": 0.0 }, { "disease_id": "DOID:83", "name": "cataract", "description": "A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision.", "url": "https://disease-ontology.org/term/DOID:83", "evidence": [ { "id": "83", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:83" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "cytoplasmic side of endoplasmic reticulum membrane", "id": "GO:0098554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098554", "evidence": [ { "database": "UniProtKB", "id": "P48450", "url": "https://www.uniprot.org/uniprotkb/P48450" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "P48450", "url": "https://www.uniprot.org/uniprotkb/P48450" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "P48450", "url": "https://www.uniprot.org/uniprotkb/P48450" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P48450", "url": "https://www.uniprot.org/uniprotkb/P48450" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "P48450", "url": 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The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom proteinuria, and has symptom renal failure.", "url": "https://disease-ontology.org/term/DOID:11266", "evidence": [ { "id": "11266", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11266" } ], "weight": 0.0 }, { "disease_id": "DOID:114", "name": "heart disease", "description": "A cardiovascular system disease that involves the heart.", "url": "https://disease-ontology.org/term/DOID:114", "evidence": [ { "id": "114", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:114" } ], "weight": 0.0 }, { "disease_id": "DOID:1168", "name": "familial hyperlipidemia", "description": "A lipid metabolism disease that is characterized by elevated levels of lipids in the blood.", "url": "https://disease-ontology.org/term/DOID:1168", "evidence": [ { "id": "1168", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1168" } ], "weight": 0.0 }, { "disease_id": "DOID:11801", "name": "protein-energy malnutrition", "description": "A nutritional deficiency disease that is characterized by inadequate dietary protein and calories, which can have profound systemic effects including decreased metabolism, altered tissue distribution, compromised immunity, and impaired growth, and has_material_basis_in dietary deprivation.", "url": "https://disease-ontology.org/term/DOID:11801", "evidence": [ { "id": "11801", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11801" } ], "weight": 0.0 }, { "disease_id": "DOID:1184", "name": "nephrotic syndrome", "description": "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability.", "url": "https://disease-ontology.org/term/DOID:1184", "evidence": [ { "id": "1184", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1184" } ], "weight": 0.0 }, { "disease_id": "DOID:12351", "name": "alcoholic hepatitis", "description": "", "url": "https://disease-ontology.org/term/DOID:12351", "evidence": [ { "id": "12351", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12351" } ], "weight": 0.0 }, { "disease_id": "DOID:1240", "name": "leukemia", "description": "A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.", "url": "https://disease-ontology.org/term/DOID:1240", "evidence": [ { "id": "1240", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1240" } ], "weight": 0.0 }, { "disease_id": "DOID:13576", "name": "twin-to-twin transfusion syndrome", "description": "A neonatal anemia that is characterized by an increased number of arteriovenous anastomoses deep in the placenta. These capillary connections occur in the cotyledon portion of the placenta. Unidirectional flow can occur in these arteriovenous anastomoses and result in shunting of blood towards one twin and away from the other when the arteriovenous anastomoses are unbalanced.", "url": "https://disease-ontology.org/term/DOID:13576", "evidence": [ { "id": "13576", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13576" } ], "weight": 0.0 }, { "disease_id": "DOID:13580", "name": "cholestasis", "description": "A bile duct disease that is characterized by where bile cannot flow from the liver to the duodenum.", "url": "https://disease-ontology.org/term/DOID:13580", "evidence": [ { "id": "13580", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13580" } ], "weight": 0.0 }, { "disease_id": "DOID:13603", "name": "obstructive jaundice", "description": "A cholestasis characterized by yellowish pigmentation of the skin and sclera due to high bilirubin levels resulting from biliary tract obstruction.", "url": "https://disease-ontology.org/term/DOID:13603", "evidence": [ { "id": "13603", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13603" } ], "weight": 0.0 }, { "disease_id": "DOID:14089", "name": "root caries", "description": "", "url": "https://disease-ontology.org/term/DOID:14089", "evidence": [ { "id": "14089", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14089" } ], "weight": 0.0 }, { "disease_id": "DOID:14525", "name": "Reye syndrome", "description": "A syndrome characterized by acute brain damage and liver function problems. It has been associated with aspirin consumption by children with viral illness, although it also occurs in the absence of aspirin use.", "url": "https://disease-ontology.org/term/DOID:14525", "evidence": [ { "id": "14525", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14525" } ], "weight": 0.0 }, { "disease_id": "DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas.", "url": "https://disease-ontology.org/term/DOID:1793", "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ], "weight": 0.0 }, { "disease_id": "DOID:2855", "name": "hyperthyroxinemia", "description": "A thyroid gland disease that is characterized by elevated thyroxine levels in the blood.", "url": "https://disease-ontology.org/term/DOID:2855", "evidence": [ { "id": "2855", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2855" } ], "weight": 0.0 }, { "disease_id": "DOID:3525", "name": "middle cerebral artery infarction", "description": "", "url": "https://disease-ontology.org/term/DOID:3525", "evidence": [ { "id": "3525", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3525" } ], "weight": 0.0 }, { "disease_id": "DOID:3587", "name": "pancreatic ductal carcinoma", "description": "A pancreatic carcinoma located_in the pancreatic duct.", "url": "https://disease-ontology.org/term/DOID:3587", "evidence": [ { "id": "3587", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3587" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:4947", "name": "cholangiocarcinoma", "description": "A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells.", "url": "https://disease-ontology.org/term/DOID:4947", "evidence": [ { "id": "4947", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4947" } ], "weight": 0.0 }, { "disease_id": "DOID:5082", "name": "liver cirrhosis", "description": "", "url": "https://disease-ontology.org/term/DOID:5082", "evidence": [ { "id": "5082", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5082" } ], "weight": 0.0 }, { "disease_id": "DOID:552", "name": "pneumonia", "description": "A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing.", "url": "https://disease-ontology.org/term/DOID:552", "evidence": [ { "id": "552", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:552" } ], "weight": 0.0 }, { "disease_id": "DOID:576", "name": "proteinuria", "description": "A kidney disease that is characterized by the presence of excess proteins in the urine.", "url": "https://disease-ontology.org/term/DOID:576", "evidence": [ { "id": "576", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:576" } ], "weight": 0.0 }, { "disease_id": "DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.", "url": "https://disease-ontology.org/term/DOID:6000", "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ], "weight": 0.0 }, { "disease_id": "DOID:620", "name": "blood protein disease", "description": "", "url": "https://disease-ontology.org/term/DOID:620", "evidence": [ { "id": "620", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:620" } ], "weight": 0.0 }, { "disease_id": "DOID:6271", "name": "gastric cardia adenocarcinoma", "description": "", "url": "https://disease-ontology.org/term/DOID:6271", "evidence": [ { "id": "6271", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6271" } ], "weight": 0.0 }, { "disease_id": "DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", "url": "https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ], "weight": 0.0 }, { "disease_id": "DOID:783", "name": "end stage renal disease", "description": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease.", "url": "https://disease-ontology.org/term/DOID:783", "evidence": [ { "id": "783", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:783" } ], "weight": 0.0 }, { "disease_id": "DOID:8893", "name": "psoriasis", "description": "A skin disease that is characterized by patches of thick red skin and silvery scales.", "url": "https://disease-ontology.org/term/DOID:8893", "evidence": [ { "id": "8893", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8893" } ], "weight": 0.0 }, { "disease_id": "DOID:8924", "name": "autoimmune thrombocytopenic purpura", "description": "A primary thrombocytopenia that involves relatively few platelets in blood as a result of autoantibodies.", "url": "https://disease-ontology.org/term/DOID:8924", "evidence": [ { "id": "8924", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8924" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 }, { "disease_id": "DOID:9538", "name": "multiple myeloma", "description": "A myeloid neoplasm that is located_in the plasma cells in bone marrow.", "url": "https://disease-ontology.org/term/DOID:9538", "evidence": [ { "id": "9538", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9538" } ], "weight": 0.0 }, { "disease_id": "DOID:9675", "name": "pulmonary emphysema", "description": "A chronic obstructive pulmonary disease that is characterized by permanent enlargement of air spaces distal to the terminal bronchioles and the destruction of the alveolar walls.", "url": "https://disease-ontology.org/term/DOID:9675", "evidence": [ { "id": "9675", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9675" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "fatty acid binding", "id": "GO:0005504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005504", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "toxic substance binding", "id": "GO:0015643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015643", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "small molecule binding", "id": "GO:0036094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036094", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "modified amino acid binding", "id": "GO:0072341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072341", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "enterobactin binding", "id": "GO:1903981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903981", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "exogenous protein binding", "id": "GO:0140272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140272", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "molecular carrier activity", "id": "GO:0140104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140104", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "oxygen binding", "id": "GO:0019825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" } ], "biological_process": [ { "name": "response to nutrient", "id": "GO:0007584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007584", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "response to nutrient levels", "id": "GO:0031667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031667", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "vasodilation", "id": "GO:0042311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042311", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "cellular response to starvation", "id": "GO:0009267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009267", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "response to mercury ion", "id": "GO:0046689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046689", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } ], "pmid": "" }, { "name": "response to platinum ion", "id": "GO:0070541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070541", "evidence": [ { "database": "UniProtKB", "id": "P02770", "url": "https://www.uniprot.org/uniprotkb/P02770" } 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thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.", "url": "https://disease-ontology.org/term/DOID:10652", "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ], "weight": 0.0 }, { "disease_id": "DOID:11088", "name": "asphyxia neonatorum", "description": "A respiratory system disease that is characterized by deprivation of oxygen to a newborn infant that lasts long enough during the birth process to cause physical harm, usually to the brain.", "url": "https://disease-ontology.org/term/DOID:11088", "evidence": [ { "id": "11088", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11088" } ], "weight": 0.0 }, { 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"url": "https://www.uniprot.org/uniprotkb/P63045" } ], "pmid": "" }, { "name": "exocytic insertion of neurotransmitter receptor to postsynaptic membrane", "id": "GO:0098967", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098967", "evidence": [ { "database": "UniProtKB", "id": "P63045", "url": "https://www.uniprot.org/uniprotkb/P63045" } ], "pmid": "" }, { "name": "SNARE complex assembly", "id": "GO:0035493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035493", "evidence": [ { "database": "UniProtKB", "id": "P63045", "url": "https://www.uniprot.org/uniprotkb/P63045" } ], "pmid": "" }, { "name": "synaptic vesicle exocytosis", "id": "GO:0016079", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016079", "evidence": [ { "database": "UniProtKB", "id": "P63045", "url": "https://www.uniprot.org/uniprotkb/P63045" } ], "pmid": "" }, { "name": "regulation of synaptic vesicle recycling", "id": "GO:1903421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903421", "evidence": [ { "database": 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"https://www.uniprot.org/uniprotkb/P63045" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "P63045", "url": "https://www.uniprot.org/uniprotkb/P63045" } ], "pmid": "" }, { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "P63045", "url": "https://www.uniprot.org/uniprotkb/P63045" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P63045", "url": "https://www.uniprot.org/uniprotkb/P63045" } ], "pmid": "" }, { "name": "calcium-dependent protein binding", "id": "GO:0048306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048306", "evidence": [ { "database": "UniProtKB", "id": "P63045", "url": 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} ], "pmid": "" }, { "name": "syntaxin binding", "id": "GO:0019905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905", "evidence": [ { "database": "UniProtKB", "id": "P63045", "url": "https://www.uniprot.org/uniprotkb/P63045" } ], "pmid": "" }, { "name": "SNARE binding", "id": "GO:0000149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149", "evidence": [ { "database": "UniProtKB", "id": "P63045", "url": "https://www.uniprot.org/uniprotkb/P63045" } ], "pmid": "" }, { "name": "SNAP receptor activity", "id": "GO:0005484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005484", "evidence": [ { "database": "UniProtKB", "id": "P63045", "url": "https://www.uniprot.org/uniprotkb/P63045" } ], "pmid": "" }, { "name": "syntaxin-1 binding", "id": "GO:0017075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017075", "evidence": [ { "database": "UniProtKB", "id": "P63045", "url": "https://www.uniprot.org/uniprotkb/P63045" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "Q5FVR2-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q5FVR2", "url": "https://www.uniprot.org/uniprotkb/Q5FVR2" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 476, "chemical_mass": 49901.0, "gene_names": "Sco2;Tymp;Ecgf1;TP;Tymp", "protein_name": "Thymidine phosphorylase", "disease": [ { "disease_id": "DOID:0050700", "name": "cardiomyopathy", "description": "A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle.", "url": "https://disease-ontology.org/term/DOID:0050700", "evidence": [ { "id": "0050700", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050700" } ], "weight": 0.0 }, { "disease_id": "DOID:0060074", "name": "ductal carcinoma in situ", "description": "A breast carcinoma in situ that is characterized by 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"database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080119" } ], "weight": 0.0 }, { "disease_id": "DOID:0080357", "name": "mitochondrial complex IV deficiency nuclear type 2", "description": "A COX deficiency, infantile mitochondrial myopathy that has_material_basis_in compound heterozygous mutation in the SCO2 gene on chromosome 22q13.", "url": "https://disease-ontology.org/term/DOID:0080357", "evidence": [ { "id": "0080357", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080357" } ], "weight": 0.0 }, { "disease_id": "DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder.", "url": "https://disease-ontology.org/term/DOID:11054", "evidence": [ { "id": "11054", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11054" } ], "weight": 0.0 }, { "disease_id": "DOID:11830", "name": "myopia", "description": "A refractive error 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"description": "A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers.", "url": "https://disease-ontology.org/term/DOID:3307", "evidence": [ { "id": "3307", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3307" } ], "weight": 0.0 }, { "disease_id": "DOID:3587", "name": "pancreatic ductal carcinoma", "description": "A pancreatic carcinoma located_in the pancreatic duct.", "url": "https://disease-ontology.org/term/DOID:3587", "evidence": [ { "id": "3587", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3587" } ], "weight": 0.0 }, { "disease_id": "DOID:3744", "name": "cervical squamous cell carcinoma", "description": "A cervix carcinoma that has_material_basis_in squamous cells of the cervix.", "url": "https://disease-ontology.org/term/DOID:3744", "evidence": [ { "id": "3744", "database": "AGR", "url": 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"disease_id": "DOID:409", "name": "liver disease", "description": "", "url": "https://disease-ontology.org/term/DOID:409", "evidence": [ { "id": "409", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:409" } ], "weight": 0.0 }, { "disease_id": "DOID:4440", "name": "seminoma", "description": "A germinoma that has_material_basis_in cells that make sperm and eggs.", "url": "https://disease-ontology.org/term/DOID:4440", "evidence": [ { "id": "4440", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4440" } ], "weight": 0.0 }, { "disease_id": "DOID:4450", "name": "renal cell carcinoma", "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney.", "url": "https://disease-ontology.org/term/DOID:4450", "evidence": [ { "id": "4450", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4450" } ], "weight": 0.0 }, { "disease_id": "DOID:4608", "name": "common bile duct 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This disorder results in a microcytic anemia that is clinically mild.", "url": "https://disease-ontology.org/term/DOID:0080773", "evidence": [ { "id": "0080773", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080773" } ], "weight": 0.0 }, { "disease_id": "DOID:0081445", "name": "sickle cell disease", "description": "A blood protein disease that is characterized by chronic hemolytic anemia and intermittent vaso-occlusive events that result in tissue ischemia leading to acute and chronic pain as well as organ damage that can affect any organ system, resulting from the replacement of one of the beta-globin subunits in hemoglobin with atypical hemoglobin molecules called hemoglobin S which can distort red blood cells into a sickle or crescent shape. Sickle cell disease subtypes should include a detailed genotypic description for the hemoglobin molecules (e.g., Hb S/S, Hb S/C, Hb S/0-thalassemia).", "url": "https://disease-ontology.org/term/DOID:0081445", "evidence": [ { "id": "0081445", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0081445" } ], "weight": 0.0 }, { "disease_id": "DOID:0111363", "name": "Heinz body anemia", "description": "A congenital nonspherocytic hemolytic anemia characterized by nonspherocytic hemolytic anemia of Dacie type I with Heinz bodies seen in erythrocytes after splenectomy that has_material_basis_in heterozygous mutation in the HBA1, HBA2 or HBB genes on chromosome 11p15.4, 16p13.3, and 16p13.3, respectively.", "url": "https://disease-ontology.org/term/DOID:0111363", "evidence": [ { "id": "0111363", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111363" } ], "weight": 0.0 }, { "disease_id": "DOID:0111632", "name": "familial erythrocytosis 6", "description": "A primary polycythemia characterized by high oxygen affinity hemoglobin and compensatory polycythemia that has_material_basis_in heterozygous mutation in HBB on chromosome 11p15.4.", "url": "https://disease-ontology.org/term/DOID:0111632", "evidence": [ { "id": "0111632", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111632" } ], "weight": 0.0 }, { "disease_id": "DOID:10923", "name": "sickle cell anemia", "description": "A sickle cell disease that is characterized by the replacement of both of the beta-globin subunits in hemoglobin with hemoglobin S, resulting in a low number of red blood cells, repeated infections, and periodic episodes of pain.", "url": "https://disease-ontology.org/term/DOID:10923", "evidence": [ { "id": "10923", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10923" } ], "weight": 0.0 }, { "disease_id": "DOID:1099", "name": "alpha thalassemia", "description": "A thalassemia involving the genes HBA1and HBA2 hemoglobin genes.", "url": "https://disease-ontology.org/term/DOID:1099", "evidence": [ { "id": "1099", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1099" } ], "weight": 0.0 }, { "disease_id": "DOID:12241", "name": "beta thalassemia", "description": "A thalassemia characterized by the reduced or absent synthesis of the beta globin chains of hemoglobin.", "url": "https://disease-ontology.org/term/DOID:12241", "evidence": [ { "id": "12241", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12241" } ], "weight": 0.0 }, { "disease_id": "DOID:12365", "name": "malaria", "description": "A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.", "url": "https://disease-ontology.org/term/DOID:12365", "evidence": [ { "id": "12365", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12365" } ], "weight": 0.0 }, { "disease_id": "DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.", "url": "https://disease-ontology.org/term/DOID:14330", "evidence": [ { "id": "14330", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14330" } ], "weight": 0.0 }, { "disease_id": "DOID:1584", "name": "acute chest syndrome", "description": "A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. 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The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.", "url": "https://disease-ontology.org/term/DOID:1584", "evidence": [ { "id": "1584", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1584" } ], "weight": 0.0 }, { "disease_id": "DOID:2355", "name": "anemia", "description": "A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells.", "url": "https://disease-ontology.org/term/DOID:2355", "evidence": [ { "id": "2355", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2355" } ], "weight": 0.0 }, { "disease_id": "DOID:2859", "name": "hemoglobin C disease", "description": "", "url": "https://disease-ontology.org/term/DOID:2859", "evidence": [ { "id": "2859", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2859" } ], "weight": 0.0 }, { "disease_id": "DOID:2860", "name": "hemoglobinopathy", "description": "", "url": "https://disease-ontology.org/term/DOID:2860", "evidence": [ { "id": "2860", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2860" } ], "weight": 0.0 }, { "disease_id": "DOID:589", "name": "congenital hemolytic anemia", "description": "", "url": "https://disease-ontology.org/term/DOID:589", "evidence": [ { "id": "589", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:589" } ], "weight": 0.0 }, { "disease_id": "DOID:8432", "name": "polycythemia", "description": "A bone marrow disease characterized by an increased number of red blood cells in the bloodstream resulting in thicker blood and reduced blood flow.", "url": "https://disease-ontology.org/term/DOID:8432", "evidence": [ { "id": "8432", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:8432" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P02091", "url": "https://www.uniprot.org/uniprotkb/P02091" } ], "pmid": "" }, { "name": "hemoglobin complex", "id": "GO:0005833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005833", "evidence": [ { "database": "UniProtKB", "id": "P02091", "url": "https://www.uniprot.org/uniprotkb/P02091" } ], "pmid": "" }, { "name": "haptoglobin-hemoglobin complex", "id": "GO:0031838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031838", "evidence": [ { "database": "UniProtKB", "id": "P02091", "url": "https://www.uniprot.org/uniprotkb/P02091" } ], "pmid": "" } ], "biological_process": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "P02091", "url": "https://www.uniprot.org/uniprotkb/P02091" } ], "pmid": "" }, { "name": "response to hydrogen peroxide", "id": "GO:0042542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042542", "evidence": [ { "database": "UniProtKB", "id": "P02091", "url": "https://www.uniprot.org/uniprotkb/P02091" } ], "pmid": "" }, { "name": "hemopoiesis", "id": "GO:0030097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030097", "evidence": [ { "database": "UniProtKB", "id": "P02091", "url": "https://www.uniprot.org/uniprotkb/P02091" } ], "pmid": "" }, { "name": "hydrogen peroxide catabolic process", "id": "GO:0042744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042744", "evidence": [ { "database": "UniProtKB", "id": "P02091", "url": "https://www.uniprot.org/uniprotkb/P02091" } ], "pmid": "" }, { "name": "carbon dioxide transport", "id": "GO:0015670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015670", "evidence": [ { "database": "UniProtKB", "id": "P02091", "url": "https://www.uniprot.org/uniprotkb/P02091" } ], "pmid": "" }, { "name": "renal absorption", "id": "GO:0070293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070293", "evidence": [ { "database": "UniProtKB", "id": "P02091", "url": "https://www.uniprot.org/uniprotkb/P02091" } ], "pmid": "" }, { "name": "nitric oxide transport", "id": "GO:0030185", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030185", "evidence": [ { "database": "UniProtKB", "id": "P02091", "url": "https://www.uniprot.org/uniprotkb/P02091" } ], "pmid": "" }, { "name": "erythrocyte development", "id": "GO:0048821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048821", "evidence": [ { "database": "UniProtKB", "id": "P02091", "url": "https://www.uniprot.org/uniprotkb/P02091" } ], "pmid": "" }, { "name": "cellular oxidant detoxification", "id": "GO:0098869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098869", "evidence": [ { "database": "UniProtKB", "id": "P02091", "url": "https://www.uniprot.org/uniprotkb/P02091" } ], "pmid": "" }, { "name": "regulation of eIF2 alpha phosphorylation by heme", "id": 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The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior.", "url": "https://disease-ontology.org/term/DOID:0060041", "evidence": [ { "id": "0060041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060041" } ], "weight": 0.0 }, { "disease_id": "DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate.", "url": "https://disease-ontology.org/term/DOID:10283", "evidence": [ { "id": "10283", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10283" } ], "weight": 0.0 } ], "molecular_function": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "phospholipid 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], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "growth cone", "id": "GO:0030426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "dendritic shaft", "id": "GO:0043198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043198", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" } ], "biological_process": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "positive regulation of GTPase activity", "id": "GO:0043547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "positive regulation of cell adhesion", "id": "GO:0045785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045785", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "positive regulation of substrate adhesion-dependent cell spreading", "id": "GO:1900026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900026", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "negative regulation of TOR signaling", "id": "GO:0032007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032007", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "reactive oxygen species metabolic process", "id": "GO:0072593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072593", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "regulation of actin filament polymerization", "id": "GO:0030833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030833", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "T cell differentiation", "id": "GO:0030217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030217", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "regulation of dendrite development", "id": "GO:0050773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050773", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" }, { "name": "neutrophil chemotaxis", "id": "GO:0030593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030593", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLR6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLR6" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A8I6GLU8-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 414, "chemical_mass": 44518.0, "gene_names": "Tardbp;Tardbp;Tdp-43", "protein_name": "TAR DNA-binding protein 43", "disease": [ { "disease_id": "DOID:0050848", "name": "obstructive sleep apnea", "description": "A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep.", "url": "https://disease-ontology.org/term/DOID:0050848", "evidence": [ { "id": "0050848", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050848" } ], "weight": 0.0 }, { "disease_id": "DOID:0060201", "name": "amyotrophic lateral sclerosis type 10", "description": "An amyotrophic lateral sclerosis that has_material_basis_in mutation in the TARDBP gene on chromosome 1.", "url": "https://disease-ontology.org/term/DOID:0060201", "evidence": [ { "id": "0060201", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060201" } ], "weight": 0.0 }, { "disease_id": "DOID:0060672", "name": "frontotemporal dementia 2", "description": "A frontotemporal dementia characterized by variable phenotypic expression typically including social, behavioral, or language deterioration, rather than memory or motor deficits and the presence of TARDBP-positive inclusions that has_material_basis_in mutation in the GRN gene on chromosome 17q21.31.", "url": "https://disease-ontology.org/term/DOID:0060672", "evidence": [ { "id": "0060672", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060672" } ], "weight": 0.0 }, { "disease_id": "DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.", "url": "https://disease-ontology.org/term/DOID:10652", "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ], "weight": 0.0 }, { "disease_id": "DOID:11870", "name": "Pick's disease", "description": "A frontotemporal dementia that is characterized by a spectrum of neuropsychiatric symptoms ranging from those that affect the patient's personality to those that cause a decline in cognitive function.", "url": "https://disease-ontology.org/term/DOID:11870", "evidence": [ { "id": "11870", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11870" } ], "weight": 0.0 }, { "disease_id": "DOID:12217", "name": "Lewy body dementia", "description": "A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities that has_material_basis_in accumulation of alpha-synuclein, SCNA, (protein). The causal mutation might be in SCNA or SCNB or some other gene(s) but the end result is always accumulation of SCNA in Lewy bodies.", "url": "https://disease-ontology.org/term/DOID:12217", "evidence": [ { "id": "12217", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12217" } ], "weight": 0.0 }, { "disease_id": "DOID:1289", "name": "neurodegenerative disease", "description": "A central nervous system disease that results in the progressive deterioration of function or structure of neurons.", "url": "https://disease-ontology.org/term/DOID:1289", "evidence": [ { "id": "1289", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1289" } ], "weight": 0.0 }, { "disease_id": "DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.", "url": "https://disease-ontology.org/term/DOID:14330", "evidence": [ { "id": "14330", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:14330" } ], "weight": 0.0 }, { "disease_id": "DOID:231", "name": "motor neuron disease", "description": "A neurodegenerative disease that is located_in the motor neurons.", "url": "https://disease-ontology.org/term/DOID:231", "evidence": [ { "id": "231", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:231" } ], "weight": 0.0 }, { "disease_id": "DOID:332", "name": "amyotrophic lateral sclerosis", "description": "A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.", "url": "https://disease-ontology.org/term/DOID:332", "evidence": [ { "id": "332", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:332" } ], "weight": 0.0 }, { "disease_id": "DOID:678", "name": "progressive supranuclear palsy", "description": "A movement disease that is characterized by serious and progressive problems with control of gait and balance, along with complex eye movement and thinking problems. It involves gradual deterioration and death of specific volumes of the brain.", "url": "https://disease-ontology.org/term/DOID:678", "evidence": [ { "id": "678", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:678" } ], "weight": 0.0 }, { "disease_id": "DOID:9255", "name": "frontotemporal dementia", "description": "A dementia characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language.", "url": "https://disease-ontology.org/term/DOID:9255", "evidence": [ { "id": "9255", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9255" } ], "weight": 0.0 } ], "biological_process": [ { "name": "positive regulation of protein import into nucleus", "id": "GO:0042307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042307", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "positive regulation of insulin secretion", "id": "GO:0032024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032024", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "amyloid fibril formation", "id": "GO:1990000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990000", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "negative regulation of protein phosphorylation", "id": "GO:0001933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001933", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "regulation of circadian rhythm", "id": "GO:0042752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042752", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "3'-UTR-mediated mRNA stabilization", "id": "GO:0070935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070935", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "response to endoplasmic reticulum stress", "id": "GO:0034976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034976", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "host-mediated suppression of viral transcription", "id": "GO:0043922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043922", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "gene expression", "id": "GO:0010467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "3'-UTR-mediated mRNA destabilization", "id": "GO:0061158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061158", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "nuclear inner membrane organization", "id": "GO:0071765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071765", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" } ], "cellular_component": [ { "name": "perichromatin fibrils", "id": "GO:0005726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005726", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6GLU8", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLU8" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA 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The infection has_symptom fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, clay-colored bowel movements, joint pain, and jaundice.", "url": "https://disease-ontology.org/term/DOID:2043", "evidence": [ { "id": "2043", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2043" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. 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"database": "UniProtKB", "id": "Q6MGB1", "url": "https://www.uniprot.org/uniprotkb/Q6MGB1" } ], "pmid": "" }, { "name": "cellular response to type II interferon", "id": "GO:0071346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071346", "evidence": [ { "database": "UniProtKB", "id": "Q6MGB1", "url": "https://www.uniprot.org/uniprotkb/Q6MGB1" } ], "pmid": "" }, { "name": "positive regulation of T cell activation", "id": "GO:0050870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050870", "evidence": [ { "database": "UniProtKB", "id": "Q6MGB1", "url": "https://www.uniprot.org/uniprotkb/Q6MGB1" } ], "pmid": "" }, { "name": "positive regulation of immune response", "id": "GO:0050778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050778", "evidence": [ { "database": "UniProtKB", "id": "Q6MGB1", "url": "https://www.uniprot.org/uniprotkb/Q6MGB1" } ], "pmid": "" } ], "molecular_function": [ { "name": "MHC class II protein complex binding", "id": "GO:0023026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0023026", "evidence": [ { "database": "UniProtKB", "id": "Q6MGB1", "url": "https://www.uniprot.org/uniprotkb/Q6MGB1" } ], "pmid": "" }, { "name": "peptide antigen binding", "id": "GO:0042605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042605", "evidence": [ { "database": "UniProtKB", "id": "Q6MGB1", "url": "https://www.uniprot.org/uniprotkb/Q6MGB1" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A0G2JU60-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JU60", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JU60" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 534, "chemical_mass": 57401.0, "gene_names": "Glcci1;Umad1;Glcci1;RGD1563612", "protein_name": "Glucocorticoid-induced transcript 1 protein", "disease": [ { "disease_id": "DOID:0080815", "name": "childhood-onset asthma", "description": "A chronic asthma that is characterized by first presentation in early childhood.", "url": "https://disease-ontology.org/term/DOID:0080815", "evidence": [ { "id": "0080815", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080815" } ], "weight": 0.0 }, { "disease_id": "DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries.", "url": "https://disease-ontology.org/term/DOID:10763", "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. 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The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:9351", "name": "diabetes mellitus", "description": "A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.", "url": "https://disease-ontology.org/term/DOID:9351", "evidence": [ { "id": "9351", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9351" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JU60", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JU60" } ], "pmid": "" }, { "name": "podocyte foot", "id": "GO:0098846", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098846", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JU60", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JU60" } ], "pmid": "" } ], "biological_process": [ { "name": "cellular response to glucose stimulus", "id": "GO:0071333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071333", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JU60", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JU60" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A0G2JV50-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JV50", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JV50" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 536, "chemical_mass": 58813.0, "gene_names": "Fam124a;Fam124a", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A0G2JYV2-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYV2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYV2" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 1484, "chemical_mass": 165701.0, "gene_names": "Cpsf1", "protein_name": "Cleavage and polyadenylation specificity factor subunit 1", "disease": [ { "disease_id": "DOID:11830", "name": "myopia", "description": "A refractive error characterized by the inability to see farther objects clearly.", "url": "https://disease-ontology.org/term/DOID:11830", "evidence": [ { "id": "11830", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11830" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYV2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYV2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYV2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYV2" } ], "pmid": "" }, { "name": "mRNA cleavage and polyadenylation specificity factor complex", "id": "GO:0005847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005847", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYV2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYV2" } ], "pmid": "" } ], "molecular_function": [ { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYV2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYV2" } ], "pmid": "" }, { "name": "mRNA 3'-UTR AU-rich region binding", "id": "GO:0035925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035925", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYV2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYV2" } ], "pmid": "" } ], "biological_process": [ { "name": "mRNA 3'-end processing", "id": "GO:0031124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031124", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYV2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYV2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "A0A0G2JYV2-1", "start_pos": "427", "end_pos": "427", "site_lbl": "Thr427", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 427, "start_aa": "Thr", "end_pos": 427, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr427", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ] } ] }, { "uniprot_canonical_ac": "A0A0G2JYV2-1", "start_pos": "1429", "end_pos": "1429", "site_lbl": "Asp1429", "weight": 0.0, "snv": [ { "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 filters: n-glyco-sequon-gain (DIC->NIC).", "chr_id": "7", "chr_pos": "110200015", "evidence": [ { "id": "rs8156138", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs8156138" } ] } ] } ], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A0G2JZR6-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JZR6", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JZR6" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": 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The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:2945", "name": "severe acute respiratory syndrome", "description": "A Coronavirus infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Severe acute respiratory syndrome coronavirus (SARS-CoV or SARS-CoV-1), a subtype of Betacoronavirus pandemicum, which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.", "url": "https://disease-ontology.org/term/DOID:2945", "evidence": [ { "id": "2945", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2945" } ], "weight": 0.0 }, { "disease_id": "DOID:2957", "name": "pulmonary tuberculosis", "description": "A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.", "url": "https://disease-ontology.org/term/DOID:2957", "evidence": [ { "id": "2957", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2957" } ], "weight": 0.0 }, { "disease_id": "DOID:399", "name": "tuberculosis", "description": "A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.", "url": "https://disease-ontology.org/term/DOID:399", "evidence": [ { "id": "399", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:399" } ], "weight": 0.0 }, { "disease_id": "DOID:526", "name": "human immunodeficiency virus infectious disease", "description": "A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.", "url": "https://disease-ontology.org/term/DOID:526", "evidence": [ { "id": "526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:526" } ], "weight": 0.0 }, { "disease_id": "DOID:635", "name": "acquired immunodeficiency syndrome", "description": "A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per microliter of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.", "url": "https://disease-ontology.org/term/DOID:635", "evidence": [ { "id": "635", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:635" } ], "weight": 0.0 }, { "disease_id": "DOID:6432", "name": "pulmonary hypertension", "description": "A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries.", "url": "https://disease-ontology.org/term/DOID:6432", "evidence": [ { "id": "6432", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6432" } ], "weight": 0.0 } ], "biological_process": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A230", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A230" } ], "pmid": "" } ], "cellular_component": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": 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"batch.rat.3" }, { "uniprot_canonical_ac": "A0A8I6A2C7-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A2C7", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A2C7" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 596, "chemical_mass": 67097.0, "gene_names": "4930519F16Rikl;4930519F16Rikl;RGD1562521", "protein_name": "", "disease": [], "molecular_function": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A2C7", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A2C7" } ], "pmid": "" } ], "biological_process": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A2C7", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A2C7" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "A0A8I6A2C7-1", "start_pos": "547", "end_pos": "547", "site_lbl": "Thr547", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 547, "start_aa": "Thr", "end_pos": 547, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr547", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ] } ] } ], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A8I6A315-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A315", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A315" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 314, "chemical_mass": 35483.0, "gene_names": "Aph1bl2;LOC691658", "protein_name": "Gamma-secretase subunit APH-1", "disease": [ { "disease_id": "DOID:3393", "name": "coronary artery disease", "description": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.", "url": "https://disease-ontology.org/term/DOID:3393", "evidence": [ { "id": "3393", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3393" } ], "weight": 0.0 } ], "biological_process": [ { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A315", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A315" } ], "pmid": "" }, { "name": "protein processing", "id": "GO:0016485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016485", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A315", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A315" } ], "pmid": "" }, { "name": "Notch receptor processing", "id": "GO:0007220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007220", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A315", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A315" } ], "pmid": "" }, { "name": "amyloid-beta formation", "id": "GO:0034205", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034205", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A315", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A315" } ], "pmid": "" } ], "cellular_component": [ { "name": "gamma-secretase complex", "id": "GO:0070765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070765", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A315", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A315" } ], "pmid": "" } ], "molecular_function": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A315", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A315" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A8I6A3P6-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A3P6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A3P6" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 1312, "chemical_mass": 144599.0, "gene_names": "Scube3", "protein_name": "Signal peptide, CUB and EGF-like domain-containing protein 3", "disease": [ { "disease_id": "DOID:0112358", "name": "short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2", "description": "A syndrome characterized by reduced growth, thin and short long bones, distinctive facial dysmorphism, dental and skeletal abnormalities, and absence of developmental delay or intellectual disability that has_material_basis_in homozygous or compound heterozygous mutation in the SCUBE3 gene on chromosome 6p21.31.", "url": "https://disease-ontology.org/term/DOID:0112358", "evidence": [ { "id": "0112358", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0112358" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A3P6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A3P6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A3P6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A3P6" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A3P6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A3P6" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A3P6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A3P6" } ], "pmid": "" } ], "biological_process": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A3P6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A3P6" } ], "pmid": "" }, { "name": "positive regulation of BMP signaling pathway", "id": "GO:0030513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030513", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A3P6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A3P6" } ], "pmid": "" }, { "name": "positive regulation of osteoblast differentiation", "id": "GO:0045669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045669", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A3P6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A3P6" } ], "pmid": "" }, { "name": "positive regulation of smoothened signaling pathway", "id": "GO:0045880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045880", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A3P6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A3P6" } ], "pmid": "" } ], "molecular_function": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A3P6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A3P6" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": 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"" } ], "cellular_component": [ { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AL26", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AL26" } ], "pmid": "" }, { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AL26", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AL26" } ], "pmid": "" } ], "biological_process": [ { "name": "response to bacterium", "id": "GO:0009617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009617", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AL26", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AL26" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AL26", "url": 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degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.", "url": "https://disease-ontology.org/term/DOID:10652", "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ], "weight": 0.0 }, { "disease_id": "DOID:10787", "name": "premature menopause", "description": "An ovarian dysfunction that is the loss of normal ovarian function before age 40.", "url": "https://disease-ontology.org/term/DOID:10787", "evidence": [ { "id": "10787", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10787" } ], "weight": 0.0 }, { "disease_id": "DOID:10976", "name": "membranous glomerulonephritis", "description": "", "url": "https://disease-ontology.org/term/DOID:10976", "evidence": [ { "id": "10976", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10976" } ], "weight": 0.0 }, { "disease_id": "DOID:1168", "name": 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"https://www.alliancegenome.org/disease/DOID:13619" } ], "weight": 0.0 }, { "disease_id": "DOID:1387", "name": "hypolipoproteinemia", "description": "A lipid metabolism disorder that is characterized by unusually low levels of fats in the blood.", "url": "https://disease-ontology.org/term/DOID:1387", "evidence": [ { "id": "1387", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1387" } ], "weight": 0.0 }, { "disease_id": "DOID:1388", "name": "Tangier disease", "description": "A hypolipoproteinemia that is characterized by markedly reduced levels of plasma high density lipoproteins resulting in tissue accumulation of cholesterol esters and that has_material_basis_in homozygous or compound heterozygous mutation in the ABCA1 gene on chromosome 9q31.", "url": "https://disease-ontology.org/term/DOID:1388", "evidence": [ { "id": "1388", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1388" } ], "weight": 0.0 }, { "disease_id": "DOID:1574", "name": 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"https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:684" } ], "weight": 0.0 }, { "disease_id": "DOID:783", "name": "end stage renal disease", "description": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease.", "url": "https://disease-ontology.org/term/DOID:783", "evidence": [ { "id": "783", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:783" } ], "weight": 0.0 }, { "disease_id": "DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.", "url": "https://disease-ontology.org/term/DOID:9352", "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ], "weight": 0.0 }, { "disease_id": "DOID:9452", "name": "steatotic liver disease", "description": "A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in at least 5% of hepatocytes.", "url": "https://disease-ontology.org/term/DOID:9452", "evidence": [ { "id": "9452", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9452" } ], "weight": 0.0 }, { "disease_id": "DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.", "url": "https://disease-ontology.org/term/DOID:9970", "evidence": [ { "id": "9970", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ], "weight": 0.0 } ], 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"https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "phosphatidylcholine floppase activity", "id": "GO:0090554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090554", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "phosphatidylserine floppase activity", "id": "GO:0090556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090556", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "high-density lipoprotein particle binding", "id": "GO:0008035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008035", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "phosphatidylcholine binding", "id": "GO:0031210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031210", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "sphingolipid floppase activity", "id": "GO:0046623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046623", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "protein transmembrane transporter activity", "id": "GO:0008320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008320", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "cholesterol transfer activity", "id": "GO:0120020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120020", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "floppase activity", "id": "GO:0140328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140328", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" } ], "cellular_component": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "intracellular vesicle", "id": "GO:0097708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097708", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "endocytic vesicle", "id": "GO:0030139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030139", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" } ], "biological_process": [ { "name": "phagocytosis, engulfment", "id": "GO:0006911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006911", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "response to nutrient", "id": "GO:0007584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007584", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "cholesterol metabolic process", "id": "GO:0008203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008203", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "positive regulation of cholesterol efflux", "id": "GO:0010875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010875", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "phospholipid efflux", "id": "GO:0033700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033700", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "lipoprotein metabolic process", "id": "GO:0042157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042157", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "lipoprotein biosynthetic process", "id": "GO:0042158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042158", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "cellular response to retinoic acid", "id": "GO:0071300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "cellular response to cholesterol", "id": "GO:0071397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071397", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "response to nutrient levels", "id": "GO:0031667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031667", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "cellular response to xenobiotic stimulus", "id": "GO:0071466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071466", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, { "name": "response to laminar fluid shear stress", "id": "GO:0034616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034616", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLK5", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZLK5" } ], "pmid": "" }, 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"" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "F7ETC0", "url": "https://www.uniprot.org/uniprotkb/F7ETC0" } ], "pmid": "" }, { "name": "ceramide biosynthetic process", "id": "GO:0046513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046513", "evidence": [ { "database": "UniProtKB", "id": "F7ETC0", "url": "https://www.uniprot.org/uniprotkb/F7ETC0" } ], "pmid": "" }, { "name": "cellular response to calcium ion", "id": "GO:0071277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071277", "evidence": [ { "database": "UniProtKB", "id": "F7ETC0", "url": "https://www.uniprot.org/uniprotkb/F7ETC0" } ], "pmid": "" }, { "name": "ceramide metabolic process", "id": "GO:0006672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006672", "evidence": [ { "database": "UniProtKB", "id": "F7ETC0", "url": "https://www.uniprot.org/uniprotkb/F7ETC0" } ], "pmid": "" }, { "name": "response to virus", "id": "GO:0009615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009615", "evidence": [ { "database": "UniProtKB", "id": "F7ETC0", "url": "https://www.uniprot.org/uniprotkb/F7ETC0" } ], "pmid": "" }, { "name": "positive regulation of viral entry into host cell", "id": "GO:0046598", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046598", "evidence": [ { "database": "UniProtKB", "id": "F7ETC0", "url": "https://www.uniprot.org/uniprotkb/F7ETC0" } ], "pmid": "" }, { "name": "response to ionizing radiation", "id": "GO:0010212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010212", "evidence": [ { "database": "UniProtKB", "id": "F7ETC0", "url": "https://www.uniprot.org/uniprotkb/F7ETC0" } ], "pmid": "" }, { "name": "response to cocaine", "id": "GO:0042220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042220", "evidence": [ { "database": "UniProtKB", "id": "F7ETC0", "url": "https://www.uniprot.org/uniprotkb/F7ETC0" } ], "pmid": "" }, { "name": "symbiont entry into host cell", "id": "GO:0046718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046718", "evidence": [ { "database": "UniProtKB", "id": "F7ETC0", "url": "https://www.uniprot.org/uniprotkb/F7ETC0" } ], "pmid": "" }, { "name": "response to interleukin-1", "id": "GO:0070555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070555", "evidence": [ { "database": "UniProtKB", "id": "F7ETC0", "url": "https://www.uniprot.org/uniprotkb/F7ETC0" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "F7ETC0", "url": "https://www.uniprot.org/uniprotkb/F7ETC0" } ], "pmid": "" }, { "name": "positive regulation of endocytosis", "id": "GO:0045807", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045807", "evidence": [ { "database": "UniProtKB", "id": "F7ETC0", "url": "https://www.uniprot.org/uniprotkb/F7ETC0" } ], "pmid": "" }, { "name": "cellular response to UV", 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"https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "M0RCG9", "url": "https://www.uniprot.org/uniprotkb/M0RCG9" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "M0RCG9", "url": "https://www.uniprot.org/uniprotkb/M0RCG9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A0G2K254-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K254" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 641, "chemical_mass": 73605.0, "gene_names": "Ndc80", "protein_name": "Kinetochore protein NDC80", "disease": [ { "disease_id": "DOID:10534", "name": "stomach cancer", "description": 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"regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K254" } ], "pmid": "" }, { "name": "establishment of mitotic spindle orientation", "id": "GO:0000132", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000132", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K254" } ], "pmid": "" }, { "name": "centrosome duplication", "id": "GO:0051298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051298", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K254" } ], "pmid": "" }, { "name": "mitotic spindle organization", "id": "GO:0007052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007052", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K254" } ], 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"url": "https://www.uniprot.org/uniprotkb/A0A0G2K254" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K254" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K254" } ], "pmid": "" }, { "name": "outer kinetochore", "id": "GO:0000940", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000940", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K254" } ], "pmid": "" } ], "molecular_function": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K254", "url": 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"evidence": [ { "database": "UniProtKB", "id": "A0A0G2K269", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K269" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 452, "chemical_mass": 49816.0, "gene_names": "Dph1", "protein_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1", "disease": [ { "disease_id": "DOID:0060469", "name": "Miller-Dieker lissencephaly syndrome", "description": "A syndrome characterized by classical lissencephaly and distinct facial features and has_material_basis_in submicroscopic deletions of 17p13.3, including the LIS1 gene.", "url": "https://disease-ontology.org/term/DOID:0060469", "evidence": [ { "id": "0060469", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060469" } ], "weight": 0.0 }, { "disease_id": "DOID:0070476", "name": "diphthamide deficiency syndrome", "description": "An inherited metabolic disorder characterized by global developmental delay, 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"https://www.ebi.ac.uk/QuickGO/term/GO:0051536", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K269", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K269" } ], "pmid": "" }, { "name": "2-(3-amino-3-carboxypropyl)histidine synthase activity", "id": "GO:0090560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090560", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K269", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K269" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A0G2K6D8-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K6D8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K6D8" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 319, "chemical_mass": 36028.0, "gene_names": "Sirt4;SIRT4;Sirt4", "protein_name": "NAD-dependent protein lipoamidase 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The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.", "url": "https://disease-ontology.org/term/DOID:0080208", "evidence": [ { "id": "0080208", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080208" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K6D8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K6D8" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { 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"name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AH20", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AH20" } ], "pmid": "" }, { "name": "cilium movement", "id": "GO:0003341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AH20", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AH20" } ], "pmid": "" }, { "name": "maintenance of cell number", "id": "GO:0098727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098727", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AH20", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AH20" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AH20", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AH20" } ], "pmid": "" }, { "name": "cell 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organization", "id": "GO:0044782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044782", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AH20", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AH20" } ], "pmid": "" }, { "name": "gene expression", "id": "GO:0010467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AH20", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AH20" } ], "pmid": "" }, { "name": "protein-containing complex assembly", "id": "GO:0065003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AH20", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AH20" } ], "pmid": "" }, { "name": "manchette assembly", "id": "GO:1905198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905198", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AH20", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AH20" } ], "pmid": "" }, { "name": "sperm flagellum assembly", "id": "GO:0120316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120316", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AH20", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AH20" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A0G2JYM8-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYM8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYM8" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 589, "chemical_mass": 68356.0, "gene_names": "Zfp386;Kzf1;Zfp386;Znf386", "protein_name": "", "disease": [ { "disease_id": "DOID:0050700", "name": "cardiomyopathy", "description": "A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle.", "url": "https://disease-ontology.org/term/DOID:0050700", "evidence": [ { 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"https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYM8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYM8" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYM8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYM8" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYM8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYM8" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYM8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYM8" } ], "pmid": "" } ], "molecular_function": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYM8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYM8" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYM8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYM8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYM8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYM8" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYM8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYM8" } ], "pmid": "" }, { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JYM8", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JYM8" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A8I6A448-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A448", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A448" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 470, "chemical_mass": 52984.0, "gene_names": "Il5ra", "protein_name": "Interleukin-5 receptor subunit alpha", "disease": [ { "disease_id": "DOID:1273", "name": "respiratory syncytial virus infectious disease", "description": "A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus (Orthopneumovirus hominis), which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.", "url": "https://disease-ontology.org/term/DOID:1273", "evidence": [ { "id": "1273", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1273" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. 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The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:350", "name": "mastocytosis", "description": "", "url": "https://disease-ontology.org/term/DOID:350", "evidence": [ { "id": "350", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:350" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A448", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A448" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A448", "url": 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"binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A8I5ZXX8-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZXX8", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZXX8" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 178, "chemical_mass": 19979.0, "gene_names": "C3h20orf144;C3h20orf144;RGD1561517", "protein_name": "", "disease": [], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "F7F7D5-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "F7F7D5", "url": "https://www.uniprot.org/uniprotkb/F7F7D5" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 581, "chemical_mass": 66523.0, "gene_names": "Ttc39a;RGD1311126;Ttc39a", "protein_name": "", "disease": [], "cellular_component": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F7F7D5", "url": "https://www.uniprot.org/uniprotkb/F7F7D5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A8I6A795-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A795", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A795" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 262, "chemical_mass": 31301.0, "gene_names": "Srsf10;Fusip1;Srsf10", "protein_name": "Serine/arginine-rich splicing factor 10", "disease": [ { "disease_id": "DOID:4448", "name": "macular degeneration", "description": "A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss.", "url": "https://disease-ontology.org/term/DOID:4448", "evidence": [ { "id": "4448", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4448" } ], "weight": 0.0 } ], "biological_process": [ { "name": "RNA splicing, via transesterification reactions", "id": "GO:0000375", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000375", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A795", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A795" } ], "pmid": "" }, { "name": "negative regulation of mRNA splicing, via spliceosome", "id": "GO:0048025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048025", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6A795", "url": "https://www.uniprot.org/uniprotkb/A0A8I6A795" } ], "pmid": "" }, { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { 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"GO:0035774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035774", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "regulation of cytosolic calcium ion concentration", "id": "GO:0051480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051480", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "cellular response to calcium ion", "id": "GO:0071277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071277", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "cellular response to forskolin", "id": "GO:1904322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904322", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "modulation of chemical synaptic transmission", "id": "GO:0050804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050804", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "positive regulation of synaptic plasticity", "id": "GO:0031915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031915", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "long-term memory", "id": "GO:0007616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007616", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "cellular response to morphine", "id": "GO:0071315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071315", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "positive regulation of long-term synaptic depression", "id": "GO:1900454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900454", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "glucose mediated signaling pathway", "id": "GO:0010255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010255", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "G protein-coupled opioid receptor signaling pathway", "id": "GO:0038003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038003", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "regulation of cellular response to stress", "id": "GO:0080135", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080135", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "neuroinflammatory response", "id": "GO:0150076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150076", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "cAMP/PKA signal transduction", "id": "GO:0141156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141156", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [ { "uniprot_canonical_ac": "P40146-1", "start_pos": "21", "end_pos": "21", "site_lbl": "Thr21", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 21, "start_aa": "Thr", "end_pos": 21, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr21", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "814", "end_pos": "814", "site_lbl": "Asn814", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 814, "start_aa": "Asn", "end_pos": 814, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn814", "evidence": [ { "id": "P40146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P40146#ptm_processing" } ] } ], "mutagenesis": [ { "sequence_org": "N", "sequence_mut": "Q", "comment": "Does not affect deglycosylation. Does not affect plasma membrane targeting; when associated with Q-818 and A-885. Affects membrane raft localization; when associated with Q-818 and A-885. Does not affect CCE-stimulated adenylate cyclase activity; when associated with Q-818 and A-885.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19158400", "url": "https://glygen.org/publication/PubMed/19158400" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "818", "end_pos": "818", "site_lbl": "Asn818", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 818, "start_aa": "Asn", "end_pos": 818, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn818", "evidence": [ { "id": "P40146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P40146#ptm_processing" } ] } ], "mutagenesis": [ { "sequence_org": "N", "sequence_mut": "Q", "comment": "Does not affect deglycosylation. Does not affect plasma membrane targeting; when associated with Q-814 and A-885. Affects membrane raft localization; when associated with Q-814 and A-885. Does not affect CCE-stimulated adenylate cyclase activity; when associated with Q-814 and A-885.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19158400", "url": "https://glygen.org/publication/PubMed/19158400" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "885", "end_pos": "885", "site_lbl": "Asn885", "weight": 0.0, "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 885, "start_aa": "Asn", "end_pos": 885, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn885", "evidence": [ { "id": "P40146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P40146#ptm_processing" } ] } ], "mutagenesis": [ { "sequence_org": "N", "sequence_mut": "E", "comment": "Does not affect deglycosylation. Does not affect plasma membrane targeting; when associated with Q-814 and A-818. Affects membrane raft localization; when associated with Q-814 and A-818. Does not affect CCE-stimulated adenylate cyclase activity; when associated with Q-814 and A-818.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19158400", "url": "https://glygen.org/publication/PubMed/19158400" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "611", "end_pos": "611", "site_lbl": "Ser611", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" } ] } ], "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Does not affect the stimulatoty effect of PKA inhibitoron calcium-stimulated adenylate cyclase activity.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "22976297", "url": "https://glygen.org/publication/PubMed/22976297" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "621", "end_pos": "621", "site_lbl": "Ser621", "weight": 0.0, "phosphorylation": [ { "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "P40146", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40146" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "1120", "end_pos": "1120", "site_lbl": "Ser1120", "weight": 0.0, "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Does not affect the stimulatoty effect of PKA inhibitor on calcium-stimulated adenylate cyclase activity.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "22976297", "url": "https://glygen.org/publication/PubMed/22976297" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "112", "end_pos": "112", "site_lbl": "Ser112", "weight": 0.0, "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Loses the stimulatoty effect of PKA inhibitor on calcium-stimulated adenylate cyclase activity.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "22976297", "url": "https://glygen.org/publication/PubMed/22976297" } ] }, { "sequence_org": "S", "sequence_mut": "D", "comment": "Insensitive to the stimulatory effect of PKA inhibitor on calcium-stimulated adenylate cyclase activity.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "22976297", "url": "https://glygen.org/publication/PubMed/22976297" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "1196", "end_pos": "1196", "site_lbl": "Leu1196", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "Consistently high basal adenylate cyclase activity; when associated with A-1200. Does not affect calmodulin binding; when associated with A-1200.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "1197", "end_pos": "1197", "site_lbl": "Val1197", "weight": 0.0, "mutagenesis": [ { "sequence_org": "V", "sequence_mut": "A", "comment": "Does not affect calcium activated adenylate cyclase; when associated with A-1198. Does not affect calcium activated adenylate cyclase; when associated with A-1198 and A-1202. Decreases calcium/calmodulin stimulated adenylate cyclase activity; when associated with 49-A--A-51; 38-A--A-40; A-1198 and A-1202. Has an elevated basal activity; when associated with A-1198. Has an elevated basal activity; when associated with A-1198 and A-1202. Does not affect calmodulin binding; when associated with A-1198. Does not affect calmodulin binding; when associated with A-1198 and A-1202.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] }, { "sequence_org": "V", "sequence_mut": "N", "comment": "Does not affect calcium activated adenylate cyclase. Significant high basal adenylate cyclase activity. Significant high basal adenylate cyclase activity; when associated with Q-1202.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "1198", "end_pos": "1198", "site_lbl": "Gln1198", "weight": 0.0, "mutagenesis": [ { "sequence_org": "Q", "sequence_mut": "A", "comment": "Does not affect calcium activated adenylate cyclase; when associated with A-1197. Does not affect calcium activated adenylate cyclase; when associated with A-1197 and A-1202. Decreases calcium/calmodulin stimulated adenylate cyclase activity; when associated with 49-A--A-51; 38-A--A-40; A-1197 and A-1202. Has an elevated basal activity; when associated with A-1197. Has an elevated basal activity; when associated with A-1197 and A-1202. Does not affect calmodulin binding; when associated with A-1197. Does not affect calmodulin binding; when associated with A-1197 and A-1202.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] }, { "sequence_org": "Q", "sequence_mut": "K", "comment": "Does not affect calcium activated adenylate cyclase.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "1199", "end_pos": "1199", "site_lbl": "Ser1199", "weight": 0.0, "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "D", "comment": "Increased CCE-stimulated adenylate cyclase activity. Has a high basal activity.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "1200", "end_pos": "1200", "site_lbl": "Leu1200", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "Consistently high basal adenylate cyclase activity; when associated with A-1196. Does not affect calmodulin binding; when associated with A-1196.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "1202", "end_pos": "1202", "site_lbl": "Arg1202", "weight": 0.0, "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "A", "comment": "Does not affect calcium activated adenylate cyclase; when associated with A-1197 and A-1198. Decreases calcium/calmodulin stimulated adenylate cyclase activity; when associated with 49-A--A-51; 38-A--A-40; A-1197 and A-1198. Has an elevated basal activity; when associated with A-1197 and A-1198. Does not affect calmodulin binding; when associated with A-1197 and A-1198.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] }, { "sequence_org": "R", "sequence_mut": "E", "comment": "Does not affect calcium activated adenylate cyclase; when associated with E-1204. Greatly diminishes calmodulin binding; when associated with E-1204.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] }, { "sequence_org": "R", "sequence_mut": "Q", "comment": "Does not affect calcium activated adenylate cyclase. Increases slightly basal adenylate cyclase activity but not significantly, and retains an appreciable calcium regulation. Significant high basal adenylate cyclase activity; when associated with N-1197.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "1204", "end_pos": "1204", "site_lbl": "Arg1204", "weight": 0.0, "mutagenesis": [ { "sequence_org": "R", "sequence_mut": "E", "comment": "Does not affect calcium activated adenylate cyclase; when associated with E-1202. Greatly diminishes calmodulin binding; when associated with E-1202.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "1206", "end_pos": "1206", "site_lbl": "Lys1206", "weight": 0.0, "mutagenesis": [ { "sequence_org": "K", "sequence_mut": "E", "comment": "Does not affect calcium activated adenylate cyclase. Does not affect calmodulin binding.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "1208", "end_pos": "1208", "site_lbl": "Leu1208", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "E", "comment": "Does not affect calcium activated adenylate cyclase; when associated with E-1209. Does not affect calmodulin binding; when associated with E-1209.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "1209", "end_pos": "1209", "site_lbl": "Leu1209", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "E", "comment": "Does not affect calcium activated adenylate cyclase; when associated with E-1208. Does not affect calmodulin binding; when associated with E-1208.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19305019", "url": "https://glygen.org/publication/PubMed/19305019" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "178", "end_pos": "178", "site_lbl": "Ser178", "weight": 0.0, "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Does not affect the stimulatoty effect of PKA inhibitor on calcium-stimulated adenylate cyclase activity.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "22976297", "url": "https://glygen.org/publication/PubMed/22976297" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "416", "end_pos": "416", "site_lbl": "Asp416", "weight": 0.0, "mutagenesis": [ { "sequence_org": "D", "sequence_mut": "N", "comment": "Loses adenylate cyclase activity in response to calcium.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "22399809", "url": "https://glygen.org/publication/PubMed/22399809" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "432", "end_pos": "432", "site_lbl": "Leu432", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "Does not affect dimerization; when associated with A-439. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-439. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-439. Affects membrane raft localization; when associated with A-439.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19158400", "url": "https://glygen.org/publication/PubMed/19158400" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "439", "end_pos": "439", "site_lbl": "Leu439", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "Does not affect dimerization. Does not affect dimerization;when associated with A-432. Does not affect dimerization;when associated with A-446 and A-432. Does not affect dimerization;when associated with A-432; A-446 and A-453. Dramatically reduces the levels of the N-glycosylated monomeric species. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-432. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-446 and A-432. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-453; A-432 and A-446. Loss of calcium- and calmodulin-responsive adenylate cyclase activity. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-432. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-446 and A-432. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-453; A-432 and A-446. Affects membrane raft localization. Affects membrane raft localization; when associated with A-432. Affects membrane raft localization; when associated with A-446 and A-432. Affects membrane raft localization; when associated with A-439; A-432 and A-446.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19158400", "url": "https://glygen.org/publication/PubMed/19158400" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "446", "end_pos": "446", "site_lbl": "Leu446", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "Does not affect dimerization; when associated with A-439 and A-432. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-439 and A-432. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-439 and A-432. Affects membrane raft localization; when associated with A-439 and A-432.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19158400", "url": "https://glygen.org/publication/PubMed/19158400" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "453", "end_pos": "453", "site_lbl": "Leu453", "weight": 0.0, "mutagenesis": [ { "sequence_org": "L", "sequence_mut": "A", "comment": "Does not affect dimerization; when associated with A-439; A-432 and A-446. Dramatically reduces the levels of the N-glycosylated monomeric species; when associated with A-439; A-432 and A-446. Loss of calcium- and calmodulin-responsive adenylate cyclase activity; when associated with A-439; A-432 and A-446. Affects membrane raft localization; when associated with A-439; A-432 and A-446.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "19158400", "url": "https://glygen.org/publication/PubMed/19158400" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "66", "end_pos": "66", "site_lbl": "Ser66", "weight": 0.0, "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Decraeses significantly the stimulatoty effect of PKA inhibitor on calcium-stimulated adenylate cyclase activity.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "22976297", "url": "https://glygen.org/publication/PubMed/22976297" } ] } ] }, { "uniprot_canonical_ac": "P40146-1", "start_pos": "852", "end_pos": "852", "site_lbl": "Ser852", "weight": 0.0, "mutagenesis": [ { "sequence_org": "S", "sequence_mut": "A", "comment": "Does not affect the stimulatoty effect of PKA inhibitoron calcium-stimulated adenylate cyclase activity.", "evidence": [ { "database": "UniProtKB", "id": "P40146", "url": "https://www.uniprot.org/uniprotkb/P40146" }, { "database": "PubMed", "id": "22976297", "url": "https://glygen.org/publication/PubMed/22976297" } ] } ] } ], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A8L2QF09-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8L2QF09", "url": "https://www.uniprot.org/uniprotkb/A0A8L2QF09" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 246, "chemical_mass": 27711.0, "gene_names": "Mcpt4l1;Mcpt4", "protein_name": "", "disease": [], "molecular_function": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "A0A8L2QF09", "url": "https://www.uniprot.org/uniprotkb/A0A8L2QF09" } ], "pmid": "" } ], "biological_process": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0A8L2QF09", "url": "https://www.uniprot.org/uniprotkb/A0A8L2QF09" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "A0A8L2QF09", "url": "https://www.uniprot.org/uniprotkb/A0A8L2QF09" } ], "pmid": "" } ], "cellular_component": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A8L2QF09", "url": "https://www.uniprot.org/uniprotkb/A0A8L2QF09" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A0G2K0A0-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K0A0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0A0" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 411, "chemical_mass": 47294.0, "gene_names": "Cyth4;Cyth4;Pscd4;RGD1564842", "protein_name": "", "disease": [], "cellular_component": [ { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K0A0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0A0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K0A0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0A0" } ], "pmid": "" }, { "name": "extrinsic component of synaptic membrane", "id": "GO:0099243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099243", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K0A0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0A0" } ], "pmid": "" } ], "molecular_function": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K0A0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0A0" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K0A0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0A0" } ], "pmid": "" } ], "biological_process": [ { "name": "regulation of ARF protein signal transduction", "id": "GO:0032012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032012", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K0A0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0A0" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K0A0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0A0" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "A0A8I6AUV5-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AUV5", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AUV5" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 2535, "chemical_mass": 285218.0, "gene_names": "Setd2;Setd2", "protein_name": "Histone-lysine N-methyltransferase SETD2", "disease": [ { "disease_id": "DOID:0050156", "name": "idiopathic pulmonary fibrosis", "description": "A pulmonary fibrosis that is characterized by scarring of the lung characterized by stiffness in the lungs and makes it difficult to breathe.", "url": "https://disease-ontology.org/term/DOID:0050156", "evidence": [ { "id": "0050156", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050156" } ], "weight": 0.0 }, { "disease_id": "DOID:0061043", "name": "autosomal dominant intellectual developmental disorder 70", "description": "An autosomal dominant intellectual developmental disorder characterized by mild global developmental delay, moderately impaired intellectual disability with speech difficulties, and behavioral abnormalities that has_material_basis_in a specific heterozygous missense mutation (R1740Q) in the SETD2 gene on chromosome 3p21.", "url": "https://disease-ontology.org/term/DOID:0061043", "evidence": [ { "id": "0061043", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0061043" } ], "weight": 0.0 }, { "disease_id": "DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach.", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ], "weight": 0.0 }, { "disease_id": "DOID:162", "name": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.", "url": "https://disease-ontology.org/term/DOID:162", "evidence": [ { "id": "162", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:162" } ], "weight": 0.0 }, { "disease_id": "DOID:1790", "name": "malignant mesothelioma", "description": "A cell type cancer that has_material_basis_in mesothelial tissue that develops from the thin layer of tissue that covers many of the internal organs. Exposure to airborne asbestos particles increases one's risk of developing malignant mesothelioma.", "url": "https://disease-ontology.org/term/DOID:1790", "evidence": [ { "id": "1790", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1790" } ], "weight": 0.0 }, { "disease_id": "DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver.", "url": "https://disease-ontology.org/term/DOID:3571", "evidence": [ { "id": "3571", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3571" } ], "weight": 0.0 }, { "disease_id": "DOID:3910", "name": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:3910", "evidence": [ { "id": "3910", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3910" } ], "weight": 0.0 }, { "disease_id": "DOID:4467", "name": "clear cell renal cell carcinoma", "description": "A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.", "url": "https://disease-ontology.org/term/DOID:4467", "evidence": [ { "id": "4467", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4467" } ], "weight": 0.0 }, { "disease_id": "DOID:7474", "name": "malignant pleural mesothelioma", "description": "A pleural cancer that has_material_basis_in mesothelium cells.", "url": "https://disease-ontology.org/term/DOID:7474", "evidence": [ { "id": "7474", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7474" } ], "weight": 0.0 }, { "disease_id": "DOID:9253", "name": "gastrointestinal stromal tumor", "description": "", "url": "https://disease-ontology.org/term/DOID:9253", "evidence": [ { "id": "9253", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9253" } ], "weight": 0.0 }, { "disease_id": "DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum.", "url": "https://disease-ontology.org/term/DOID:9256", "evidence": [ { "id": "9256", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9256" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AUV5", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AUV5" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AUV5", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AUV5" } ], "pmid": "" } ], "biological_process": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AUV5", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AUV5" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AUV5", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AUV5" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AUV5", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AUV5" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AUV5", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AUV5" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AUV5", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AUV5" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AUV5", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AUV5" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AUV5", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AUV5" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0A8I6AUV5", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AUV5" } ], "pmid": "" }, { "name": "response to alkaloid", "id": "GO:0043279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043279", "evidence": [ { "database": "UniProtKB", "id": 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"D3ZGK9", "url": "https://www.uniprot.org/uniprotkb/D3ZGK9" } ], "pmid": "" }, { "name": "embryonic placenta development", "id": "GO:0001892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001892", "evidence": [ { "database": "UniProtKB", "id": "D3ZGK9", "url": "https://www.uniprot.org/uniprotkb/D3ZGK9" } ], "pmid": "" }, { "name": "digestive system development", "id": "GO:0055123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055123", "evidence": [ { "database": "UniProtKB", "id": "D3ZGK9", "url": "https://www.uniprot.org/uniprotkb/D3ZGK9" } ], "pmid": "" }, { "name": "trophectodermal cellular morphogenesis", "id": "GO:0001831", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001831", "evidence": [ { "database": "UniProtKB", "id": "D3ZGK9", "url": "https://www.uniprot.org/uniprotkb/D3ZGK9" } ], "pmid": "" }, { "name": "embryonic heart tube development", "id": "GO:0035050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035050", "evidence": [ { "database": "UniProtKB", "id": "D3ZGK9", "url": "https://www.uniprot.org/uniprotkb/D3ZGK9" } ], "pmid": "" }, { "name": "formation of anatomical boundary", "id": "GO:0048859", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048859", "evidence": [ { "database": "UniProtKB", "id": "D3ZGK9", "url": "https://www.uniprot.org/uniprotkb/D3ZGK9" } ], "pmid": "" }, { "name": "anterior/posterior axis specification", "id": "GO:0009948", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009948", "evidence": [ { "database": "UniProtKB", "id": "D3ZGK9", "url": "https://www.uniprot.org/uniprotkb/D3ZGK9" } ], "pmid": "" }, { "name": "anatomical structure formation involved in morphogenesis", "id": "GO:0048646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048646", "evidence": [ { "database": "UniProtKB", "id": "D3ZGK9", "url": "https://www.uniprot.org/uniprotkb/D3ZGK9" } ], "pmid": "" }, { "name": "embryonic pattern specification", "id": "GO:0009880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009880", "evidence": [ { "database": 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"biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "D3ZX42-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZX42", "url": "https://www.uniprot.org/uniprotkb/D3ZX42" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 1065, "chemical_mass": 120966.0, "gene_names": "Rabgap1;Rabgap1", "protein_name": "Rab GTPase-activating protein 1", "disease": [], "molecular_function": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "D3ZX42", "url": "https://www.uniprot.org/uniprotkb/D3ZX42" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "D3ZX42", "url": "https://www.uniprot.org/uniprotkb/D3ZX42" } ], "pmid": "" } ], "cellular_component": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "D3ZX42", "url": "https://www.uniprot.org/uniprotkb/D3ZX42" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "D3ZX42", "url": "https://www.uniprot.org/uniprotkb/D3ZX42" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "D3ZXB9-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZXB9", "url": "https://www.uniprot.org/uniprotkb/D3ZXB9" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 997, "chemical_mass": 109741.0, "gene_names": "Snx19;Snx19", "protein_name": "Sorting nexin-19", "disease": [], "cellular_component": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D3ZXB9", "url": "https://www.uniprot.org/uniprotkb/D3ZXB9" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "D3ZXB9", "url": "https://www.uniprot.org/uniprotkb/D3ZXB9" } ], "pmid": "" } ], "biological_process": [ { "name": "chondrocyte differentiation", "id": "GO:0002062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002062", "evidence": [ { "database": "UniProtKB", "id": "D3ZXB9", "url": "https://www.uniprot.org/uniprotkb/D3ZXB9" } ], "pmid": "" }, { "name": "insulin secretion", "id": "GO:0030073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030073", "evidence": [ { "database": "UniProtKB", "id": "D3ZXB9", "url": "https://www.uniprot.org/uniprotkb/D3ZXB9" } ], "pmid": "" }, { 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"binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "D3ZXL5-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZXL5", "url": "https://www.uniprot.org/uniprotkb/D3ZXL5" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 615, "chemical_mass": 70086.0, "gene_names": "Ncbp3;Ncbp3;RGD1308139", "protein_name": "Nuclear cap-binding protein subunit 3", "disease": [], "molecular_function": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "D3ZXL5", "url": "https://www.uniprot.org/uniprotkb/D3ZXL5" } ], "pmid": "" }, { "name": "RNA 7-methylguanosine cap binding", "id": "GO:0000340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000340", "evidence": [ { "database": "UniProtKB", "id": "D3ZXL5", "url": "https://www.uniprot.org/uniprotkb/D3ZXL5" } ], "pmid": "" }, { "name": "RNA cap binding", "id": "GO:0000339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000339", "evidence": [ { "database": "UniProtKB", "id": "D3ZXL5", "url": "https://www.uniprot.org/uniprotkb/D3ZXL5" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "D3ZXL5", "url": "https://www.uniprot.org/uniprotkb/D3ZXL5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "D3ZXL5", "url": "https://www.uniprot.org/uniprotkb/D3ZXL5" } ], "pmid": "" }, { "name": "nuclear cap binding complex", "id": "GO:0005846", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005846", "evidence": [ { "database": "UniProtKB", "id": "D3ZXL5", "url": "https://www.uniprot.org/uniprotkb/D3ZXL5" } ], "pmid": "" } ], "biological_process": [ { "name": "mRNA export from nucleus", "id": "GO:0006406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006406", "evidence": [ { "database": "UniProtKB", "id": "D3ZXL5", "url": "https://www.uniprot.org/uniprotkb/D3ZXL5" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "D3ZXL5", "url": "https://www.uniprot.org/uniprotkb/D3ZXL5" } ], "pmid": "" }, { "name": "7-methylguanosine mRNA capping", "id": "GO:0006370", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006370", "evidence": [ { "database": "UniProtKB", "id": "D3ZXL5", "url": "https://www.uniprot.org/uniprotkb/D3ZXL5" } ], "pmid": "" }, { "name": "snRNA export from nucleus", "id": "GO:0006408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006408", "evidence": [ { "database": "UniProtKB", "id": "D3ZXL5", "url": "https://www.uniprot.org/uniprotkb/D3ZXL5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "D3ZXN3-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "D3ZXN3", "url": "https://www.uniprot.org/uniprotkb/D3ZXN3" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 317, "chemical_mass": 36194.0, "gene_names": "Cd209d;Cd209;Clec4m", "protein_name": "", "disease": [ { "disease_id": "DOID:0050598", "name": "extrapulmonary tuberculosis", "description": "A tuberculosis that occurs at body sites other than the lung.", "url": "https://disease-ontology.org/term/DOID:0050598", "evidence": [ { "id": "0050598", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050598" } ], "weight": 0.0 }, { "disease_id": "DOID:0050827", "name": "rheumatic heart disease", "description": "A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.", "url": "https://disease-ontology.org/term/DOID:0050827", "evidence": [ { "id": "0050827", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050827" } ], "weight": 0.0 }, { "disease_id": "DOID:0080599", "name": "Coronavirus infectious disease", "description": "A viral infectious disease that has_material_basis_in Coronavirus.", "url": "https://disease-ontology.org/term/DOID:0080599", "evidence": [ { "id": "0080599", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080599" } ], "weight": 0.0 }, { "disease_id": "DOID:11650", "name": "bronchopulmonary dysplasia", "description": "A lung disease that is characterized by underdeveloped lungs in newborns that can be easily irritated or inflamed after birth resulting in damage to the alveoli of the lungs and bronchi. Most newborns who develop BPD are born more than 10 weeks before their due dates, weigh less than 2 pounds at birth, and have breathing problems.", "url": "https://disease-ontology.org/term/DOID:11650", "evidence": [ { "id": "11650", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11650" } ], "weight": 0.0 }, { "disease_id": "DOID:12205", "name": "dengue disease", "description": "A viral infectious disease that results in infection, has_material_basis_in Dengue virus (Orthoflavivirus denguei), which are transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding.", "url": "https://disease-ontology.org/term/DOID:12205", "evidence": [ { "id": "12205", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12205" } ], "weight": 0.0 }, { "disease_id": "DOID:12206", "name": "dengue hemorrhagic fever", "description": "A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus (Orthoflavivirus denguei) serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever. Four distinct Dengue virus serotypes have been identified.", "url": "https://disease-ontology.org/term/DOID:12206", "evidence": [ { "id": "12206", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12206" } ], "weight": 0.0 }, { "disease_id": "DOID:13564", "name": "aspergillosis", "description": "An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney, heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.", "url": "https://disease-ontology.org/term/DOID:13564", "evidence": [ { "id": "13564", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13564" } ], "weight": 0.0 }, { "disease_id": "DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.", "url": "https://disease-ontology.org/term/DOID:2841", "evidence": [ { "id": "2841", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ], "weight": 0.0 }, { "disease_id": "DOID:2957", "name": "pulmonary tuberculosis", "description": "A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.", "url": "https://disease-ontology.org/term/DOID:2957", "evidence": [ { "id": "2957", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2957" } ], "weight": 0.0 }, { "disease_id": "DOID:399", "name": "tuberculosis", "description": "A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.", "url": "https://disease-ontology.org/term/DOID:399", "evidence": [ { "id": "399", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:399" } ], "weight": 0.0 }, { "disease_id": "DOID:526", "name": "human immunodeficiency virus infectious disease", "description": "A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.", "url": "https://disease-ontology.org/term/DOID:526", "evidence": [ { "id": "526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:526" } ], "weight": 0.0 }, { "disease_id": "DOID:635", "name": "acquired immunodeficiency syndrome", "description": "A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per microliter of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.", "url": "https://disease-ontology.org/term/DOID:635", "evidence": [ { "id": "635", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:635" } ], "weight": 0.0 }, { "disease_id": "DOID:6432", "name": "pulmonary hypertension", "description": "A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries.", "url": "https://disease-ontology.org/term/DOID:6432", "evidence": [ { "id": "6432", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6432" } ], "weight": 0.0 } ], "cellular_component": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "D3ZXN3", "url": "https://www.uniprot.org/uniprotkb/D3ZXN3" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": 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"D4A1V1", "url": "https://www.uniprot.org/uniprotkb/D4A1V1" } ], "pmid": "" }, { "name": "neural tube closure", "id": "GO:0001843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "database": "UniProtKB", "id": "D4A1V1", "url": "https://www.uniprot.org/uniprotkb/D4A1V1" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "D4A1V1", "url": "https://www.uniprot.org/uniprotkb/D4A1V1" } ], "pmid": "" }, { "name": "heart looping", "id": "GO:0001947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001947", "evidence": [ { "database": "UniProtKB", "id": "D4A1V1", "url": "https://www.uniprot.org/uniprotkb/D4A1V1" } ], "pmid": "" }, { "name": "motile cilium assembly", "id": "GO:0044458", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044458", "evidence": [ { "database": "UniProtKB", "id": "D4A1V1", "url": 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basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "D4A1V1", "url": "https://www.uniprot.org/uniprotkb/D4A1V1" } ], "pmid": "" }, { "name": "photoreceptor connecting cilium", "id": "GO:0032391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032391", "evidence": [ { "database": "UniProtKB", "id": "D4A1V1", "url": "https://www.uniprot.org/uniprotkb/D4A1V1" } ], "pmid": "" }, { "name": "ciliary base", "id": "GO:0097546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097546", "evidence": [ { "database": "UniProtKB", "id": "D4A1V1", "url": "https://www.uniprot.org/uniprotkb/D4A1V1" } ], "pmid": "" }, { "name": "dendrite terminus", "id": "GO:0044292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044292", "evidence": [ { "database": "UniProtKB", "id": "D4A1V1", "url": "https://www.uniprot.org/uniprotkb/D4A1V1" } ], "pmid": "" }, { "name": "intraciliary transport particle A", "id": "GO:0030991", "url": 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killing of gram-negative bacterium", "id": "GO:0070945", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070945", "evidence": [ { "database": "UniProtKB", "id": "D4A488", "url": "https://www.uniprot.org/uniprotkb/D4A488" } ], "pmid": "" }, { "name": "neutrophil-mediated killing of fungus", "id": "GO:0070947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070947", "evidence": [ { "database": "UniProtKB", "id": "D4A488", "url": "https://www.uniprot.org/uniprotkb/D4A488" } ], "pmid": "" }, { "name": "positive regulation of leukocyte tethering or rolling", "id": "GO:1903238", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903238", "evidence": [ { "database": "UniProtKB", "id": "D4A488", "url": "https://www.uniprot.org/uniprotkb/D4A488" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "D4A488", "url": 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"https://www.uniprot.org/uniprotkb/F1M0C0" } ], "pmid": "" }, { "name": "neurogenesis", "id": "GO:0022008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022008", "evidence": [ { "database": "UniProtKB", "id": "F1M0C0", "url": "https://www.uniprot.org/uniprotkb/F1M0C0" } ], "pmid": "" }, { "name": "outflow tract morphogenesis", "id": "GO:0003151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003151", "evidence": [ { "database": "UniProtKB", "id": "F1M0C0", "url": "https://www.uniprot.org/uniprotkb/F1M0C0" } ], "pmid": "" }, { "name": "positive regulation of cell cycle G1/S phase transition", "id": "GO:1902808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902808", "evidence": [ { "database": "UniProtKB", "id": "F1M0C0", "url": "https://www.uniprot.org/uniprotkb/F1M0C0" } ], "pmid": "" }, { "name": "atrioventricular canal morphogenesis", "id": "GO:1905222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905222", "evidence": [ { "database": "UniProtKB", "id": "F1M0C0", "url": 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"id": "F1M1Y4", "url": "https://www.uniprot.org/uniprotkb/F1M1Y4" } ], "pmid": "" }, { "name": "histone H3K4me3 reader activity", "id": "GO:0140002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140002", "evidence": [ { "database": "UniProtKB", "id": "F1M1Y4", "url": "https://www.uniprot.org/uniprotkb/F1M1Y4" } ], "pmid": "" }, { "name": "histone H3K36me3 reader activity", "id": "GO:0140003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140003", "evidence": [ { "database": "UniProtKB", "id": "F1M1Y4", "url": "https://www.uniprot.org/uniprotkb/F1M1Y4" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1M1Y4", "url": "https://www.uniprot.org/uniprotkb/F1M1Y4" } ], "pmid": "" }, { "name": "ESC/E(Z) complex", "id": "GO:0035098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035098", "evidence": [ { "database": "UniProtKB", "id": "F1M1Y4", "url": 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"UniProtKB", "id": "F1M2T9", "url": "https://www.uniprot.org/uniprotkb/F1M2T9" } ], "pmid": "" } ], "cellular_component": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1M2T9", "url": "https://www.uniprot.org/uniprotkb/F1M2T9" } ], "pmid": "" } ], "biological_process": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "F1M2T9", "url": "https://www.uniprot.org/uniprotkb/F1M2T9" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "F1M443-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "F1M443", "url": "https://www.uniprot.org/uniprotkb/F1M443" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 4243, "chemical_mass": 474984.0, "gene_names": "Lrp1b", "protein_name": "Low-density lipoprotein receptor-related protein 1B", "disease": [ { "disease_id": "DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach.", "url": "https://disease-ontology.org/term/DOID:10534", "evidence": [ { "id": "10534", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10534" } ], "weight": 0.0 }, { "disease_id": "DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung.", "url": "https://disease-ontology.org/term/DOID:1324", "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ], "weight": 0.0 }, { "disease_id": "DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.", "url": "https://disease-ontology.org/term/DOID:1826", "evidence": [ { "id": "1826", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ], "weight": 0.0 }, { "disease_id": "DOID:1909", "name": "melanoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.", "url": "https://disease-ontology.org/term/DOID:1909", "evidence": [ { "id": "1909", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1909" } ], "weight": 0.0 }, { "disease_id": "DOID:219", "name": "colon cancer", "description": "A colorectal cancer that is located_in the colon.", "url": 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Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.", "url": "https://disease-ontology.org/term/DOID:3083", "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ], "weight": 0.0 }, { "disease_id": "DOID:3121", "name": "gallbladder cancer", "description": "A biliary tract cancer that is located_in the gallbladder.", "url": "https://disease-ontology.org/term/DOID:3121", "evidence": [ { "id": "3121", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3121" } ], "weight": 0.0 }, { "disease_id": "DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.", "url": "https://disease-ontology.org/term/DOID:3908", "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ], "weight": 0.0 }, { "disease_id": "DOID:3910", "name": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.", "url": "https://disease-ontology.org/term/DOID:3910", "evidence": [ { "id": "3910", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3910" } ], "weight": 0.0 }, { "disease_id": "DOID:4928", "name": "intrahepatic cholangiocarcinoma", "description": "A cholangiocarcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree.", "url": "https://disease-ontology.org/term/DOID:4928", "evidence": [ { "id": "4928", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4928" } ], "weight": 0.0 }, { "disease_id": "DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", "url": "https://disease-ontology.org/term/DOID:684", "evidence": [ { "id": "684", "database": "AGR", 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"https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1M443", "url": "https://www.uniprot.org/uniprotkb/F1M443" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "F1M443", "url": "https://www.uniprot.org/uniprotkb/F1M443" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "F1M443", "url": "https://www.uniprot.org/uniprotkb/F1M443" } ], "pmid": "" } ], "molecular_function": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1M443", "url": "https://www.uniprot.org/uniprotkb/F1M443" } ], "pmid": "" }, { "name": "low-density lipoprotein particle receptor activity", "id": "GO:0005041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005041", "evidence": [ { "database": "UniProtKB", "id": "F1M443", "url": "https://www.uniprot.org/uniprotkb/F1M443" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "F1M6E7-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "F1M6E7", "url": "https://www.uniprot.org/uniprotkb/F1M6E7" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 163, "chemical_mass": 18304.0, "gene_names": "Spaca3;Lyzc;Spaca3", "protein_name": "Sperm acrosome membrane-associated protein 3", "disease": [ { "disease_id": "DOID:934", "name": "viral infectious disease", "description": "A disease by infectious agent that results in infection, has_material_basis_in Viruses.", "url": "https://disease-ontology.org/term/DOID:934", "evidence": [ { "id": "934", "database": "AGR", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0009311", "evidence": [ { "database": "UniProtKB", "id": "G3V7T2", "url": "https://www.uniprot.org/uniprotkb/G3V7T2" } ], "pmid": "" }, { "name": "N-glycan processing", "id": "GO:0006491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006491", "evidence": [ { "database": "UniProtKB", "id": "G3V7T2", "url": "https://www.uniprot.org/uniprotkb/G3V7T2" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "G3V7W9-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "G3V7W9", "url": "https://www.uniprot.org/uniprotkb/G3V7W9" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 134, "chemical_mass": 14586.0, "gene_names": "Ifitm5;Ifitm5", "protein_name": "", "disease": [ { "disease_id": "DOID:0110344", "name": "osteogenesis imperfecta type 5", "description": "An osteogenesis imperfecta that has_material_basis_in mutation in the IFITM5 gene on chromosome 11p15.", "url": "https://disease-ontology.org/term/DOID:0110344", "evidence": [ { "id": "0110344", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110344" } ], "weight": 0.0 } ], "biological_process": [ { "name": "in utero embryonic development", "id": "GO:0001701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "database": "UniProtKB", "id": "G3V7W9", "url": "https://www.uniprot.org/uniprotkb/G3V7W9" } ], "pmid": "" }, { "name": "skeletal system development", "id": "GO:0001501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001501", "evidence": [ { "database": "UniProtKB", "id": "G3V7W9", "url": "https://www.uniprot.org/uniprotkb/G3V7W9" } ], "pmid": "" }, { "name": "bone morphogenesis", "id": "GO:0060349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060349", "evidence": [ { "database": "UniProtKB", "id": "G3V7W9", "url": 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"positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "G3V7Y6", "url": "https://www.uniprot.org/uniprotkb/G3V7Y6" } ], "pmid": "" }, { "name": "anterior/posterior pattern specification", "id": "GO:0009952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009952", "evidence": [ { "database": "UniProtKB", "id": "G3V7Y6", "url": "https://www.uniprot.org/uniprotkb/G3V7Y6" } ], "pmid": "" }, { "name": "determination of left/right symmetry", "id": "GO:0007368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007368", "evidence": [ { "database": "UniProtKB", "id": "G3V7Y6", "url": "https://www.uniprot.org/uniprotkb/G3V7Y6" } ], "pmid": "" }, { "name": "heart looping", "id": "GO:0001947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001947", "evidence": [ { "database": "UniProtKB", "id": "G3V7Y6", "url": "https://www.uniprot.org/uniprotkb/G3V7Y6" } ], "pmid": "" }, { "name": "cellular response to cytokine stimulus", "id": "GO:0071345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071345", "evidence": [ { "database": "UniProtKB", "id": "G3V7Y6", "url": "https://www.uniprot.org/uniprotkb/G3V7Y6" } ], "pmid": "" }, { "name": "aorta morphogenesis", "id": "GO:0035909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035909", "evidence": [ { "database": "UniProtKB", "id": "G3V7Y6", "url": "https://www.uniprot.org/uniprotkb/G3V7Y6" } ], "pmid": "" }, { "name": "hepatocyte differentiation", "id": "GO:0070365", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070365", "evidence": [ { "database": "UniProtKB", "id": "G3V7Y6", "url": "https://www.uniprot.org/uniprotkb/G3V7Y6" } ], "pmid": "" }, { "name": "outflow tract morphogenesis", "id": "GO:0003151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003151", "evidence": [ { "database": "UniProtKB", "id": "G3V7Y6", "url": "https://www.uniprot.org/uniprotkb/G3V7Y6" } ], "pmid": "" }, { "name": "secondary heart 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], "pmid": "" }, { "name": "negative regulation of androgen receptor signaling pathway", "id": "GO:0060766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060766", "evidence": [ { "database": "UniProtKB", "id": "G3V7Y6", "url": "https://www.uniprot.org/uniprotkb/G3V7Y6" } ], "pmid": "" }, { "name": "axial mesoderm development", "id": "GO:0048318", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048318", "evidence": [ { "database": "UniProtKB", "id": "G3V7Y6", "url": "https://www.uniprot.org/uniprotkb/G3V7Y6" } ], "pmid": "" } ], "cellular_component": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "G3V7Y6", "url": "https://www.uniprot.org/uniprotkb/G3V7Y6" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "G3V7Y6", "url": 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} ], "pmid": "" }, { "name": "dTTP biosynthetic process", "id": "GO:0006235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006235", "evidence": [ { "database": "UniProtKB", "id": "G3V816", "url": "https://www.uniprot.org/uniprotkb/G3V816" } ], "pmid": "" }, { "name": "nucleoside triphosphate biosynthetic process", "id": "GO:0009142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009142", "evidence": [ { "database": "UniProtKB", "id": "G3V816", "url": "https://www.uniprot.org/uniprotkb/G3V816" } ], "pmid": "" }, { "name": "mitochondrial outer membrane fusion", "id": "GO:1990626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990626", "evidence": [ { "database": "UniProtKB", "id": "G3V816", "url": "https://www.uniprot.org/uniprotkb/G3V816" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "G3V870-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", 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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045010", "evidence": [ { "database": "UniProtKB", "id": "G3V870", "url": "https://www.uniprot.org/uniprotkb/G3V870" } ], "pmid": "" }, { "name": "Golgi vesicle transport", "id": "GO:0048193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048193", "evidence": [ { "database": "UniProtKB", "id": "G3V870", "url": "https://www.uniprot.org/uniprotkb/G3V870" } ], "pmid": "" }, { "name": "polar body extrusion after meiotic divisions", "id": "GO:0040038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040038", "evidence": [ { "database": "UniProtKB", "id": "G3V870", "url": "https://www.uniprot.org/uniprotkb/G3V870" } ], "pmid": "" }, { "name": "establishment of meiotic spindle localization", "id": "GO:0051295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051295", "evidence": [ { "database": "UniProtKB", "id": "G3V870", "url": "https://www.uniprot.org/uniprotkb/G3V870" } ], "pmid": "" }, { "name": "formin-nucleated actin cable assembly", "id": "GO:0070649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070649", "evidence": [ { "database": "UniProtKB", "id": "G3V870", "url": "https://www.uniprot.org/uniprotkb/G3V870" } ], "pmid": "" }, { "name": "positive regulation of double-strand break repair", "id": "GO:2000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000781", "evidence": [ { "database": "UniProtKB", "id": "G3V870", "url": "https://www.uniprot.org/uniprotkb/G3V870" } ], "pmid": "" }, { "name": "cleavage furrow formation", "id": "GO:0036089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036089", "evidence": [ { "database": "UniProtKB", "id": "G3V870", "url": "https://www.uniprot.org/uniprotkb/G3V870" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "G3V892-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "G3V892", "url": "https://www.uniprot.org/uniprotkb/G3V892" } ], 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"GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "G3V8C5", "url": "https://www.uniprot.org/uniprotkb/G3V8C5" } ], "pmid": "" } ], "molecular_function": [ { "name": "aspartic-type endopeptidase activity", "id": "GO:0004190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004190", "evidence": [ { "database": "UniProtKB", "id": "G3V8C5", "url": "https://www.uniprot.org/uniprotkb/G3V8C5" } ], "pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "G3V8D4-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "G3V8D4", "url": "https://www.uniprot.org/uniprotkb/G3V8D4" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 97, "chemical_mass": 10695.0, "gene_names": "Apoc2;Apo-CII;ApoC-II;Apoc2;RGD1560725", "protein_name": "Apolipoprotein 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"" }, { "name": "cerebral cortex development", "id": "GO:0021987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021987", "evidence": [ { "database": "UniProtKB", "id": "G3V918", "url": "https://www.uniprot.org/uniprotkb/G3V918" } ], "pmid": "" }, { "name": "cerebellum development", "id": "GO:0021549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021549", "evidence": [ { "database": "UniProtKB", "id": "G3V918", "url": "https://www.uniprot.org/uniprotkb/G3V918" } ], "pmid": "" }, { "name": "GMP biosynthetic process", "id": "GO:0006177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006177", "evidence": [ { "database": "UniProtKB", "id": "G3V918", "url": "https://www.uniprot.org/uniprotkb/G3V918" } ], "pmid": "" }, { "name": "purine nucleotide biosynthetic process", "id": "GO:0006164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006164", "evidence": [ { "database": "UniProtKB", "id": "G3V918", "url": "https://www.uniprot.org/uniprotkb/G3V918" } ], "pmid": "" }, { "name": "'de 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"G3V970", "url": "https://www.uniprot.org/uniprotkb/G3V970" } ], "pmid": "" }, { "name": "trigeminal ganglion development", "id": "GO:0061551", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061551", "evidence": [ { "database": "UniProtKB", "id": "G3V970", "url": "https://www.uniprot.org/uniprotkb/G3V970" } ], "pmid": "" }, { "name": "metanephric mesenchyme development", "id": "GO:0072075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072075", "evidence": [ { "database": "UniProtKB", "id": "G3V970", "url": "https://www.uniprot.org/uniprotkb/G3V970" } ], "pmid": "" }, { "name": "regulation of skeletal muscle cell differentiation", "id": "GO:2001014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001014", "evidence": [ { "database": "UniProtKB", "id": "G3V970", "url": "https://www.uniprot.org/uniprotkb/G3V970" } ], "pmid": "" }, { "name": "regulation of synaptic assembly at neuromuscular junction", "id": "GO:0008582", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008582", "evidence": 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10116, "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 349, "chemical_mass": 39032.0, "gene_names": "Wnt7a;Wnt7a", "protein_name": "Protein Wnt", "disease": [ { "disease_id": "DOID:0090067", "name": "Fuhrmann syndrome", "description": "A bone development disease that is characterized by bowing of the femora, aplasia or hypoplasia of the fibulae and poly-, oligo-, and syndactyly that has_material_basis_in autosomal recessive inheritance of homozygous mutation in the Wnt family member 7A (WNT7A) gene on chromosome 3p25.", "url": "https://disease-ontology.org/term/DOID:0090067", "evidence": [ { "id": "0090067", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0090067" } ], "weight": 0.0 }, { "disease_id": "DOID:0112181", "name": "Schinzel type phocomelia", "description": "A syndrome characterized 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"name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" } ], "biological_process": [ { "name": "regulation of axonogenesis", "id": "GO:0050770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050770", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "embryonic axis specification", "id": "GO:0000578", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000578", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "establishment of blood-brain barrier", "id": "GO:0060856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060856", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "angiogenesis", "id": "GO:0001525", "url": 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process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "synapse organization", "id": "GO:0050808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050808", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "positive regulation of protein metabolic process", "id": "GO:0051247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051247", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "positive regulation of excitatory postsynaptic potential", "id": "GO:2000463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000463", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell migration", "id": "GO:0010595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010595", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "embryonic limb morphogenesis", "id": "GO:0030326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030326", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "response to estradiol", "id": "GO:0032355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032355", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "embryonic forelimb morphogenesis", "id": "GO:0035115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035115", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "positive regulation of synapse assembly", "id": "GO:0051965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051965", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "wound healing, spreading of epidermal cells", "id": "GO:0035313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035313", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "cellular response to transforming growth factor beta stimulus", "id": "GO:0071560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071560", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "response to estrogen", "id": "GO:0043627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043627", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "Wnt signaling pathway, planar cell polarity pathway", "id": "GO:0060071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060071", "evidence": [ { "database": "UniProtKB", "id": "M0R9D3", "url": "https://www.uniprot.org/uniprotkb/M0R9D3" } ], "pmid": "" }, { "name": "limb development", "id": "GO:0060173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060173", "evidence": [ { "database": "UniProtKB", "id": 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"pmid": "" } ], "binding_glycans": [], "biomarkers": [], "sites": [], "record_id": "batch.rat.3" }, { "uniprot_canonical_ac": "M0RDM4-1", "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "M0RDM4", "url": "https://www.uniprot.org/uniprotkb/M0RDM4" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "length": 128, "chemical_mass": 14068.0, "gene_names": "H2ac12;H2ac12", "protein_name": "Histone H2A", "disease": [], "molecular_function": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "M0RDM4", "url": "https://www.uniprot.org/uniprotkb/M0RDM4" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "M0RDM4", "url": 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