{
    "disease_id": "DOID:0090030",
    "recommended_name": {
        "id": "DOID:0090030",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0090030",
        "name": "corticosteroid-binding globulin deficiency",
        "description": "An adrenal gland disease characterized by decreased levels of serum corticosteroid-binding globulin and cortisol, and in some cases hypo- or hypertension, and muscle fatigue that has_material_basis_in heterozygous or homozygous mutation in the SERPINA6 gene on chromosome 14q32."
    },
    "synonyms": [
        {
            "id": "DOID:0090030",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0090030",
            "name": "CBG deficiency",
            "description": ""
        },
        {
            "id": "DOID:0090030",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0090030",
            "name": "transcortin deficiency",
            "description": ""
        },
        {
            "id": "MONDO:0012675",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012675",
            "name": "corticosteroid-binding globulin deficiency",
            "description": "Corticosteroid-binding globulin deficiency is a genetic disorder characterized by extreme tiredness (fatigue), particularly after physical exertion, and low blood pressure (hypotension). Corticosteroid-binding globulin (CBG) is a protein primarily produced in the liver that attaches to cortisol, a hormone with numerous functions, including maintaining blood sugar levels, protecting the body from stress, and suppressing inflammation.When cortisol is needed in the body, CBG delivers the cortisol where it is needed and releases it. Signs and symptoms of CBG deficiency vary. While some individuals may experience no symptoms, others are found to have a fatty liver and chronic pain. Some people with CBG deficiency also have chronic fatigue syndrome. CGB deficiency is caused by mutations in the SERPINA6 gene. The SERPINA6 gene is commonly also referred to as the CBG gene. Both autosomal dominant and autosomal recessive inheritance have been reported.While there is still no cure, treatment options will depend on the type and severity of symptoms present and may involve several specialists."
        },
        {
            "id": "MONDO:0012675",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012675",
            "name": "CBG deficiency",
            "description": ""
        },
        {
            "id": "MONDO:0012675",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012675",
            "name": "Transcortin deficiency",
            "description": ""
        },
        {
            "id": "MONDO:0012675",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012675",
            "name": "corticosteroid-binding globulin deficiency",
            "description": ""
        },
        {
            "id": "MONDO:0012675",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012675",
            "name": "transcortin deficiency",
            "description": ""
        },
        {
            "id": "MIM:611489",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/611489",
            "name": "Corticosteroid-binding globulin deficiency",
            "description": "Corticosteroid-binding globulin deficiency"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0090030"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0090030",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0090030",
            "categories": []
        },
        {
            "id": "MONDO:0012675",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012675",
            "categories": []
        },
        {
            "id": "MIM:611489",
            "database": "MIM",
            "url": "https://www.omim.org/entry/611489",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A8M1NHL5-1",
            "uniprot_ac": "A0A8M1NHL5",
            "uniprot_id": "A0A8M1NHL5_DANRE",
            "refseq_ac": "NP_001108176",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Thyroxine-binding globulin",
                    "type": "recommended"
                },
                {
                    "name": "Serpin A7",
                    "type": "synonym"
                },
                {
                    "name": "T4-binding globulin",
                    "type": "synonym"
                },
                {
                    "name": "serpin peptidase inhibitor",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein LOC100137107 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "wu:fb66f08",
                    "type": "recommended"
                },
                {
                    "name": "wu:fb66f08",
                    "type": "synonym"
                },
                {
                    "name": "wu:fb68e04",
                    "type": "synonym"
                },
                {
                    "name": "zgc:174260",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M1NHL5-1",
            "evidence": [
                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0AB40EBQ7-1",
            "uniprot_ac": "A0AB40EBQ7",
            "uniprot_id": "A0AB40EBQ7_DANRE",
            "refseq_ac": "NP_001104678",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Thyroxine-binding globulin",
                    "type": "recommended"
                },
                {
                    "name": "Serpin A7",
                    "type": "synonym"
                },
                {
                    "name": "T4-binding globulin",
                    "type": "synonym"
                },
                {
                    "name": "alpha-1-antitrypsin homolog",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein LOC791587 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "zgc:174259",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AB40EBQ7-1",
            "evidence": [
                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "F8W5D3-1",
            "uniprot_ac": "F8W5D3",
            "uniprot_id": "F8W5D3_DANRE",
            "refseq_ac": "XP_695000",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Thyroxine-binding globulin",
                    "type": "recommended"
                },
                {
                    "name": "Serpin A7",
                    "type": "synonym"
                },
                {
                    "name": "T4-binding globulin",
                    "type": "synonym"
                },
                {
                    "name": "alpha-1-antiproteinase 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "si:ch211-186e20.7",
                    "type": "recommended"
                },
                {
                    "name": "si:ch211-186e20.7",
                    "type": "synonym"
                }
            ],
            "record_id": "F8W5D3-1",
            "evidence": [
                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "F8W5C3-1",
            "uniprot_ac": "F8W5C3",
            "uniprot_id": "F8W5C3_DANRE",
            "refseq_ac": "NP_001099059",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Thyroxine-binding globulin",
                    "type": "recommended"
                },
                {
                    "name": "Serpin A7",
                    "type": "synonym"
                },
                {
                    "name": "T4-binding globulin",
                    "type": "synonym"
                },
                {
                    "name": "serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 precursor",
                    "type": "synonym"
                },
                {
                    "name": "serpin peptidase inhibitor-like",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "serpina7",
                    "type": "recommended"
                },
                {
                    "name": "serpina7",
                    "type": "synonym"
                },
                {
                    "name": "zgc:103617",
                    "type": "synonym"
                }
            ],
            "record_id": "F8W5C3-1",
            "evidence": [
                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q06770-1",
            "uniprot_ac": "Q06770",
            "uniprot_id": "CBG_MOUSE",
            "refseq_ac": "NP_031644",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Corticosteroid-binding globulin",
                    "type": "recommended"
                },
                {
                    "name": "CBG",
                    "type": "synonym"
                },
                {
                    "name": "Serpin A6",
                    "type": "synonym"
                },
                {
                    "name": "Transcortin",
                    "type": "synonym"
                },
                {
                    "name": "corticosteroid-binding globulin precursor",
                    "type": "synonym"
                },
                {
                    "name": "corticosteroid-binding globulin",
                    "type": "synonym"
                },
                {
                    "name": "serine (or cysteine) proteinase inhibitor, clade A, member 6",
                    "type": "synonym"
                },
                {
                    "name": "serpin A6",
                    "type": "synonym"
                },
                {
                    "name": "transcortin",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Serpina6",
                    "type": "recommended"
                },
                {
                    "name": "Cbg",
                    "type": "synonym"
                },
                {
                    "name": "Serpina6",
                    "type": "synonym"
                }
            ],
            "record_id": "Q06770-1",
            "evidence": [
                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P08185-1",
            "uniprot_ac": "P08185",
            "uniprot_id": "CBG_HUMAN",
            "refseq_ac": "NP_001747",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Corticosteroid-binding globulin",
                    "type": "recommended"
                },
                {
                    "name": "CBG",
                    "type": "synonym"
                },
                {
                    "name": "Serpin A6",
                    "type": "synonym"
                },
                {
                    "name": "Transcortin",
                    "type": "synonym"
                },
                {
                    "name": "corticosteroid-binding globulin precursor",
                    "type": "synonym"
                },
                {
                    "name": "corticosteroid-binding globulin",
                    "type": "synonym"
                },
                {
                    "name": "serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6",
                    "type": "synonym"
                },
                {
                    "name": "serpin A6",
                    "type": "synonym"
                },
                {
                    "name": "serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6",
                    "type": "synonym"
                },
                {
                    "name": "transcortin",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "SERPINA6",
                    "type": "recommended"
                },
                {
                    "name": "CBG",
                    "type": "synonym"
                },
                {
                    "name": "SERPINA6",
                    "type": "synonym"
                }
            ],
            "record_id": "P08185-1",
            "evidence": [
                {
                    "id": "611489",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/611489"
                },
                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P31211-1",
            "uniprot_ac": "P31211",
            "uniprot_id": "CBG_RAT",
            "refseq_ac": "NP_001009663",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Corticosteroid-binding globulin",
                    "type": "recommended"
                },
                {
                    "name": "CBG",
                    "type": "synonym"
                },
                {
                    "name": "Corticosteroid binding globulin",
                    "type": "synonym"
                },
                {
                    "name": "Serpin A6",
                    "type": "synonym"
                },
                {
                    "name": "Transcortin",
                    "type": "synonym"
                },
                {
                    "name": "corticosteroid-binding globulin precursor",
                    "type": "synonym"
                },
                {
                    "name": "corticosteroid-binding globulin",
                    "type": "synonym"
                },
                {
                    "name": "serine (or cysteine) peptidase inhibitor, clade A, member 6",
                    "type": "synonym"
                },
                {
                    "name": "serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6",
                    "type": "synonym"
                },
                {
                    "name": "serpin A6",
                    "type": "synonym"
                },
                {
                    "name": "serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6",
                    "type": "synonym"
                },
                {
                    "name": "serpin peptidase inhibitor, clade A, member 6",
                    "type": "synonym"
                },
                {
                    "name": "transcortin",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Serpina6",
                    "type": "recommended"
                },
                {
                    "name": "Cbg",
                    "type": "synonym"
                },
                {
                    "name": "Serpina6",
                    "type": "synonym"
                }
            ],
            "record_id": "P31211-1",
            "evidence": [
                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VFC1-1",
            "uniprot_ac": "Q9VFC1",
            "uniprot_id": "Q9VFC1_DROME",
            "refseq_ac": "NP_650427",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG6687-PA",
                    "type": "synonym"
                },
                {
                    "name": "Dm-serpin-88Eb",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 88Eb",
                    "type": "synonym"
                },
                {
                    "name": "Spn88Eb-PA",
                    "type": "synonym"
                },
                {
                    "name": "serpin 88Eb",
                    "type": "synonym"
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            ],
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                {
                    "name": "Spn88Eb",
                    "type": "recommended"
                },
                {
                    "name": "CG6687",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG6687",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG6687",
                    "type": "synonym"
                },
                {
                    "name": "Spn88EB",
                    "type": "synonym"
                },
                {
                    "name": "Spn88Eb",
                    "type": "synonym"
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                {
                    "name": "serpin",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VFC1-1",
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                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9V3N1-1",
            "uniprot_ac": "Q9V3N1",
            "uniprot_id": "SP27A_DROME",
            "refseq_ac": "NP_001260143",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Serine protease inhibitor 27A",
                    "type": "recommended"
                },
                {
                    "name": "CG11331-PB",
                    "type": "synonym"
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                {
                    "name": "Dm-serpin-27A",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 27A",
                    "type": "synonym"
                },
                {
                    "name": "Serpin-27A",
                    "type": "synonym"
                },
                {
                    "name": "Serpin27A",
                    "type": "synonym"
                },
                {
                    "name": "Spn27A-PB",
                    "type": "synonym"
                },
                {
                    "name": "serpin 27A, isoform B",
                    "type": "synonym"
                },
                {
                    "name": "serpin 27A",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Spn27A",
                    "type": "recommended"
                },
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                    "name": "CG11331",
                    "type": "synonym"
                },
                {
                    "name": "Dm-Spn27A",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG11331",
                    "type": "synonym"
                },
                {
                    "name": "EST1",
                    "type": "synonym"
                },
                {
                    "name": "Sp27A",
                    "type": "synonym"
                },
                {
                    "name": "Spn27A",
                    "type": "synonym"
                },
                {
                    "name": "Spn27a",
                    "type": "synonym"
                },
                {
                    "name": "Spn27",
                    "type": "synonym"
                },
                {
                    "name": "sp27A",
                    "type": "synonym"
                },
                {
                    "name": "spn27A",
                    "type": "synonym"
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            ],
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            "evidence": [
                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q0E8V6-1",
            "uniprot_ac": "Q0E8V6",
            "uniprot_id": "Q0E8V6_DROME",
            "refseq_ac": "NP_001036345",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG31902-PB",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 28Da",
                    "type": "synonym"
                },
                {
                    "name": "Spn28Da-PB",
                    "type": "synonym"
                },
                {
                    "name": "serpin 28Da",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Spn28Da",
                    "type": "recommended"
                },
                {
                    "name": "CG12318",
                    "type": "synonym"
                },
                {
                    "name": "CG31902",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG31902",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG31902",
                    "type": "synonym"
                },
                {
                    "name": "Spn28Da",
                    "type": "synonym"
                }
            ],
            "record_id": "Q0E8V6-1",
            "evidence": [
                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q7YTY6-1",
            "uniprot_ac": "Q7YTY6",
            "uniprot_id": "SP42D_DROME",
            "refseq_ac": "NP_001163067",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Serine protease inhibitor 42Dd",
                    "type": "recommended"
                },
                {
                    "name": "CG9456-PB",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 42Dd",
                    "type": "synonym"
                },
                {
                    "name": "Spn42Dd-PB",
                    "type": "synonym"
                },
                {
                    "name": "serine protease inhibitor 1",
                    "type": "synonym"
                },
                {
                    "name": "serpin 1",
                    "type": "synonym"
                },
                {
                    "name": "serpin 42Dd",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Spn42Dd",
                    "type": "recommended"
                },
                {
                    "name": "CG9456",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG9456",
                    "type": "synonym"
                },
                {
                    "name": "Spn1",
                    "type": "synonym"
                },
                {
                    "name": "Spn42Dd",
                    "type": "synonym"
                },
                {
                    "name": "sp1",
                    "type": "synonym"
                }
            ],
            "record_id": "Q7YTY6-1",
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                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VLQ7-1",
            "uniprot_ac": "Q9VLQ7",
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                {
                    "name": "Drosophila melanogaster",
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                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "CG8137-PA",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 28F",
                    "type": "synonym"
                },
                {
                    "name": "Spn28F-PA",
                    "type": "synonym"
                },
                {
                    "name": "serine protease inhibitor 2",
                    "type": "synonym"
                },
                {
                    "name": "serpin 28F",
                    "type": "synonym"
                },
                {
                    "name": "serpin 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Spn28F",
                    "type": "recommended"
                },
                {
                    "name": "CG8137",
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                },
                {
                    "name": "Dmel\\CG8137",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG8137",
                    "type": "synonym"
                },
                {
                    "name": "Sp2",
                    "type": "synonym"
                },
                {
                    "name": "Spn28F",
                    "type": "synonym"
                },
                {
                    "name": "Spn2",
                    "type": "synonym"
                },
                {
                    "name": "sp2",
                    "type": "synonym"
                },
                {
                    "name": "spn2",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
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                {
                    "name": "Drosophila melanogaster",
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                }
            ],
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                {
                    "name": "CG9334-PA",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 38F, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "Spn38F-PA",
                    "type": "synonym"
                },
                {
                    "name": "serine protease inhibitor 3",
                    "type": "synonym"
                },
                {
                    "name": "serpin 38F, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "serpin 3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Spn38F",
                    "type": "recommended"
                },
                {
                    "name": "CG9334",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG9334",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG9334",
                    "type": "synonym"
                },
                {
                    "name": "Sp3",
                    "type": "synonym"
                },
                {
                    "name": "Spn38F",
                    "type": "synonym"
                },
                {
                    "name": "Spn3",
                    "type": "synonym"
                },
                {
                    "name": "sp3",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VLU4-1",
            "uniprot_ac": "Q9VLU4",
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                {
                    "name": "Drosophila melanogaster",
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                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "Serine protease inhibitor 28Dc",
                    "type": "recommended"
                },
                {
                    "name": "CG7219-PA",
                    "type": "synonym"
                },
                {
                    "name": "Dm-serpin-28D",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 28Dc",
                    "type": "synonym"
                },
                {
                    "name": "Serpin-28D",
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                },
                {
                    "name": "Serpin28Dc",
                    "type": "synonym"
                },
                {
                    "name": "Spn28Dc-PA",
                    "type": "synonym"
                },
                {
                    "name": "serpin 28Dc",
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                },
                {
                    "name": "serpin 28D",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Spn28Dc",
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                },
                {
                    "name": "CG7219",
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                },
                {
                    "name": "Dm-Spn28D",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG7219",
                    "type": "synonym"
                },
                {
                    "name": "Spn28Dc",
                    "type": "synonym"
                },
                {
                    "name": "Spn28D",
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                },
                {
                    "name": "spn28D",
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                }
            ],
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                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VLV3-1",
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                }
            ],
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                {
                    "name": "CG33121-PB",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 28Db",
                    "type": "synonym"
                },
                {
                    "name": "Spn28Db-PB",
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                {
                    "name": "serpin 28Db",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Spn28Db",
                    "type": "recommended"
                },
                {
                    "name": "CG12318",
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                },
                {
                    "name": "CG33121",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG33121",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG33121",
                    "type": "synonym"
                },
                {
                    "name": "Spn28Db",
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                }
            ],
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                    "id": "0090030",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
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                }
            ],
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                {
                    "name": "Serine protease inhibitor 88Ea",
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                },
                {
                    "name": "CG18525-PA",
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                },
                {
                    "name": "Dm-serpin-88Ea",
                    "type": "synonym"
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                {
                    "name": "Serpin 88Ea",
                    "type": "synonym"
                },
                {
                    "name": "Spn88Ea-PA",
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                },
                {
                    "name": "serine protease inhibitor 5",
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                },
                {
                    "name": "serpin 5",
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                },
                {
                    "name": "serpin 88Ea, isoform A",
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                },
                {
                    "name": "serpin5",
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                {
                    "name": "serpin",
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                }
            ],
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                    "name": "Spn88Ea",
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                },
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                    "name": "CG18525",
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                },
                {
                    "name": "Dmel\\CG18525",
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                },
                {
                    "name": "Sp5",
                    "type": "synonym"
                },
                {
                    "name": "Spn5",
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                },
                {
                    "name": "Spn88Ea",
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                },
                {
                    "name": "sp5",
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                },
                {
                    "name": "spn5",
                    "type": "synonym"
                }
            ],
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                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
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                {
                    "name": "Drosophila melanogaster",
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                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                    "name": "CG6717-PB",
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                },
                {
                    "name": "Serpin 28B, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 28B, isoform B",
                    "type": "synonym"
                },
                {
                    "name": "Spn28B-PB",
                    "type": "synonym"
                },
                {
                    "name": "serine protease inhibitor 7",
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                },
                {
                    "name": "serpin 28B, isoform B",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Spn28B",
                    "type": "recommended"
                },
                {
                    "name": "CG6717",
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                },
                {
                    "name": "Dmel\\CG6717",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG6717",
                    "type": "synonym"
                },
                {
                    "name": "Spn28B",
                    "type": "synonym"
                },
                {
                    "name": "Spn7",
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                }
            ],
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                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VL44-1",
            "uniprot_ac": "Q9VL44",
            "uniprot_id": "Q9VL44_DROME",
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            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
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                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                    "name": "CG4804-PA",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 31A",
                    "type": "synonym"
                },
                {
                    "name": "Spn31A-PA",
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                },
                {
                    "name": "serpin 31A",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Spn31A",
                    "type": "recommended"
                },
                {
                    "name": "CG4804",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG4804",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG4804",
                    "type": "synonym"
                },
                {
                    "name": "Spn31A",
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                }
            ],
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                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A1Z6I3-1",
            "uniprot_ac": "A1Z6I3",
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            "refseq_ac": "NP_610188",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Drosophila melanogaster",
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                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "Serpin domain-containing protein",
                    "type": "recommended"
                },
                {
                    "name": "CG43366-PB",
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                },
                {
                    "name": "uncharacterized protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Dmel\\CG43366",
                    "type": "recommended"
                },
                {
                    "name": "CG12551",
                    "type": "synonym"
                },
                {
                    "name": "CG14470",
                    "type": "synonym"
                },
                {
                    "name": "CG43366",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG43366",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG43366",
                    "type": "synonym"
                }
            ],
            "record_id": "A1Z6I3-1",
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                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VH46-1",
            "uniprot_ac": "Q9VH46",
            "uniprot_id": "Q9VH46_DROME",
            "refseq_ac": "NP_649965",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "CG12807-PA",
                    "type": "synonym"
                },
                {
                    "name": "Serpin 85F",
                    "type": "synonym"
                },
                {
                    "name": "Spn85F-PA",
                    "type": "synonym"
                },
                {
                    "name": "serpin 85F",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Spn85F",
                    "type": "recommended"
                },
                {
                    "name": "CG12807",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG12807",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG12807",
                    "type": "synonym"
                },
                {
                    "name": "Spn85F",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VH46-1",
            "evidence": [
                {
                    "id": "0090030",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090030"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0090030"
}