{
    "disease_id": "DOID:0080810",
    "recommended_name": {
        "id": "DOID:0080810",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080810",
        "name": "acute asthma",
        "description": "An asthma that is characterized by severe and sudden onset of increasing wheezing, airways closing, smooth muscle contraction, mucus plugging and lower airway edema that may be reversible upon treatment."
    },
    "synonyms": [],
    "children": [
        {
            "id": "DOID:9362",
            "label": "status asthmaticus",
            "link_status": true,
            "children": []
        }
    ],
    "id_list": [
        "DOID:9362",
        "DOID:0080810"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080810",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080810",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A8M9Q5Q6-1",
            "uniprot_ac": "A0A8M9Q5Q6",
            "uniprot_id": "A0A8M9Q5Q6_DANRE",
            "refseq_ac": "XP_021334743",
            "glycoprotein": "no",
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                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "Interleukin-1 receptor-like 1 isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-1 receptor-like 1 isoform X1",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "il1rl1",
                    "type": "recommended"
                },
                {
                    "name": "il1rl1",
                    "type": "synonym"
                }
            ],
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            "evidence": [
                {
                    "id": "0080810",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080810"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A0G2KYH9-1",
            "uniprot_ac": "A0A0G2KYH9",
            "uniprot_id": "A0A0G2KYH9_DANRE",
            "refseq_ac": "XP_001342606",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
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                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "Growth-regulated alpha protein isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "growth-regulated alpha protein isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "cxcl8a",
                    "type": "recommended"
                },
                {
                    "name": "cxcl8a",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080810",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080810"
                }
            ]
        },
        {
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            "uniprot_ac": "N0GW19",
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                {
                    "name": "Danio rerio",
                    "taxid": 7955,
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                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "CXCL8bb",
                    "type": "synonym"
                },
                {
                    "name": "Interleukin-8b.1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "cxcl8_l2_chr17",
                    "type": "synonym"
                },
                {
                    "name": "il8l2",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-8, like 1",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-8b.1 precursor",
                    "type": "synonym"
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            ],
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                {
                    "name": "cxcl8b.1",
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                },
                {
                    "name": "cxcl8b.1",
                    "type": "synonym"
                },
                {
                    "name": "il8l1",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080810",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080810"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q99JA4-1",
            "uniprot_ac": "Q99JA4",
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            "refseq_ac": "NP_001268788",
            "glycoprotein": "yes",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cysteinyl leukotriene receptor 1",
                    "type": "recommended"
                },
                {
                    "name": "CysLTR1",
                    "type": "synonym"
                },
                {
                    "name": "Cysteinyl leukotriene D4 receptor",
                    "type": "synonym"
                },
                {
                    "name": "LTD4 receptor",
                    "type": "synonym"
                },
                {
                    "name": "cysteinyl leukotriene D4 receptor",
                    "type": "synonym"
                },
                {
                    "name": "cysteinyl leukotriene receptor 1 isoform a",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Cysltr1",
                    "type": "recommended"
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                {
                    "name": "CysLT1R",
                    "type": "synonym"
                },
                {
                    "name": "Cyslt1r",
                    "type": "synonym"
                },
                {
                    "name": "Cyslt1",
                    "type": "synonym"
                },
                {
                    "name": "Cysltr1",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080810",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080810"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P14719-1",
            "uniprot_ac": "P14719",
            "uniprot_id": "ILRL1_MOUSE",
            "refseq_ac": "NP_001020773",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interleukin-1 receptor-like 1",
                    "type": "recommended"
                },
                {
                    "name": "3.2.2.6",
                    "type": "synonym"
                },
                {
                    "name": "Interleukin-33 receptor alpha chain",
                    "type": "synonym"
                },
                {
                    "name": "Lymphocyte antigen 84",
                    "type": "synonym"
                },
                {
                    "name": "Protein ST2",
                    "type": "synonym"
                },
                {
                    "name": "Protein T1",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-1 receptor-like 1 isoform a precursor",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-33 receptor alpha chain",
                    "type": "synonym"
                },
                {
                    "name": "lymphocyte antigen 84",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Il1rl1",
                    "type": "recommended"
                },
                {
                    "name": "DER4",
                    "type": "synonym"
                },
                {
                    "name": "Fit-1",
                    "type": "synonym"
                },
                {
                    "name": "Il1rl1",
                    "type": "synonym"
                },
                {
                    "name": "Ly84",
                    "type": "synonym"
                },
                {
                    "name": "ST2L",
                    "type": "synonym"
                },
                {
                    "name": "St2-rs1",
                    "type": "synonym"
                },
                {
                    "name": "St2",
                    "type": "synonym"
                },
                {
                    "name": "Ste2",
                    "type": "synonym"
                },
                {
                    "name": "T1/ST2",
                    "type": "synonym"
                },
                {
                    "name": "T1",
                    "type": "synonym"
                }
            ],
            "record_id": "P14719-1",
            "evidence": [
                {
                    "id": "0080810",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080810"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q924T8-1",
            "uniprot_ac": "Q924T8",
            "uniprot_id": "CLTR1_RAT",
            "refseq_ac": "NP_446093",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cysteinyl leukotriene receptor 1",
                    "type": "recommended"
                },
                {
                    "name": "CysLTR1",
                    "type": "synonym"
                },
                {
                    "name": "cysteinyl leukotriene receptor 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Cysltr1",
                    "type": "recommended"
                },
                {
                    "name": "Cyslt1",
                    "type": "synonym"
                },
                {
                    "name": "Cysltr1",
                    "type": "synonym"
                }
            ],
            "record_id": "Q924T8-1",
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                {
                    "id": "0080810",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080810"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q62611-1",
            "uniprot_ac": "Q62611",
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            "refseq_ac": "NP_001121161",
            "glycoprotein": "yes",
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                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
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            ],
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                    "name": "Interleukin-1 receptor-like 1",
                    "type": "recommended"
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                {
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                },
                {
                    "name": "Fit-1",
                    "type": "synonym"
                },
                {
                    "name": "Fos-responsive gene 1 protein",
                    "type": "synonym"
                },
                {
                    "name": "IL-33 receptor",
                    "type": "synonym"
                },
                {
                    "name": "fos-responsive gene 1 protein",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-1 receptor-like 1 isoform Fit-1M precursor",
                    "type": "synonym"
                },
                {
                    "name": "serum St2",
                    "type": "synonym"
                }
            ],
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                    "name": "Il1rl1",
                    "type": "recommended"
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                {
                    "name": "FIT1",
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                },
                {
                    "name": "Fit-1",
                    "type": "synonym"
                },
                {
                    "name": "Fit1",
                    "type": "synonym"
                },
                {
                    "name": "IL33R",
                    "type": "synonym"
                },
                {
                    "name": "Il1rl1",
                    "type": "synonym"
                },
                {
                    "name": "ST2-L",
                    "type": "synonym"
                },
                {
                    "name": "St2",
                    "type": "synonym"
                },
                {
                    "name": "T1/ST2",
                    "type": "synonym"
                },
                {
                    "name": "sST2",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080810",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080810"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9UBT3-1",
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
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                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "Dickkopf-related protein 4",
                    "type": "recommended"
                },
                {
                    "name": "Dickkopf-4",
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                },
                {
                    "name": "Dkk-4",
                    "type": "synonym"
                },
                {
                    "name": "dickkopf-4",
                    "type": "synonym"
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                {
                    "name": "dickkopf-related protein 4 precursor",
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                {
                    "name": "dickkopf-related protein 4",
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                {
                    "name": "hDkk-4",
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                    "name": "DKK4",
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                {
                    "name": "DKK-4",
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                {
                    "name": "DKK4",
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                }
            ],
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                {
                    "id": "0080810",
                    "database": "AGR",
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                }
            ]
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        {
            "uniprot_canonical_ac": "Q01638-1",
            "uniprot_ac": "Q01638",
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "Interleukin-1 receptor-like 1",
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                {
                    "name": "3.2.2.6",
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                },
                {
                    "name": "Protein ST2",
                    "type": "synonym"
                },
                {
                    "name": "homolog of mouse growth stimulation-expressed",
                    "type": "synonym"
                },
                {
                    "name": "interleukin 1 receptor-related protein",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-1 receptor-like 1 isoform 3",
                    "type": "synonym"
                },
                {
                    "name": "suppressor of tumorigenicity 2",
                    "type": "synonym"
                }
            ],
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                    "name": "IL1RL1",
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                {
                    "name": "DER4",
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                    "name": "FIT-1",
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                {
                    "name": "IL1RL1",
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                },
                {
                    "name": "IL33R",
                    "type": "synonym"
                },
                {
                    "name": "ST2L",
                    "type": "synonym"
                },
                {
                    "name": "ST2V",
                    "type": "synonym"
                },
                {
                    "name": "ST2",
                    "type": "synonym"
                },
                {
                    "name": "T1",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080810",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080810"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P10145-1",
            "uniprot_ac": "P10145",
            "uniprot_id": "IL8_HUMAN",
            "refseq_ac": "NP_000575",
            "glycoprotein": "no",
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interleukin-8",
                    "type": "recommended"
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                {
                    "name": "(Ala-IL-8)77",
                    "type": "synonym"
                },
                {
                    "name": "(Ser-IL-8)72",
                    "type": "synonym"
                },
                {
                    "name": "C-X-C motif chemokine 8",
                    "type": "synonym"
                },
                {
                    "name": "Chemokine (C-X-C motif) ligand 8",
                    "type": "synonym"
                },
                {
                    "name": "Emoctakin",
                    "type": "synonym"
                },
                {
                    "name": "GCP-1",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein III",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein II",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein IV",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein I",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein VI",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein V",
                    "type": "synonym"
                },
                {
                    "name": "Granulocyte chemotactic protein 1",
                    "type": "synonym"
                },
                {
                    "name": "IL-8(1-77)",
                    "type": "synonym"
                },
                {
                    "name": "IL-8",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form III",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form II",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form IV",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form I",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form VI",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form V",
                    "type": "synonym"
                },
                {
                    "name": "LYNAP",
                    "type": "synonym"
                },
                {
                    "name": "Lymphocyte-derived neutrophil-activating factor",
                    "type": "synonym"
                },
                {
                    "name": "MDNCF-b",
                    "type": "synonym"
                },
                {
                    "name": "MDNCF-c",
                    "type": "synonym"
                },
                {
                    "name": "MDNCF",
                    "type": "synonym"
                },
                {
                    "name": "MONAP",
                    "type": "synonym"
                },
                {
                    "name": "Monocyte-derived neutrophil chemotactic factor",
                    "type": "synonym"
                },
                {
                    "name": "Monocyte-derived neutrophil-activating peptide",
                    "type": "synonym"
                },
                {
                    "name": "NAF",
                    "type": "synonym"
                },
                {
                    "name": "NAP-1",
                    "type": "synonym"
                },
                {
                    "name": "Neutrophil-activating factor",
                    "type": "synonym"
                },
                {
                    "name": "Neutrophil-activating protein 1",
                    "type": "synonym"
                },
                {
                    "name": "Protein 3-10C",
                    "type": "synonym"
                },
                {
                    "name": "T-cell chemotactic factor",
                    "type": "synonym"
                },
                {
                    "name": "alveolar macrophage chemotactic factor I",
                    "type": "synonym"
                },
                {
                    "name": "beta endothelial cell-derived neutrophil activating peptide",
                    "type": "synonym"
                },
                {
                    "name": "beta-thromboglobulin-like protein",
                    "type": "synonym"
                },
                {
                    "name": "chemokine (C-X-C motif) ligand 8",
                    "type": "synonym"
                },
                {
                    "name": "emoctakin",
                    "type": "synonym"
                },
                {
                    "name": "granulocyte chemotactic protein 1",
                    "type": "synonym"
                },
                {
                    "name": "interleukin 8",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-8 isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "lung giant cell carcinoma-derived chemotactic protein",
                    "type": "synonym"
                },
                {
                    "name": "lymphocyte derived neutrophil activating peptide",
                    "type": "synonym"
                },
                {
                    "name": "monocyte-derived neutrophil chemotactic factor",
                    "type": "synonym"
                },
                {
                    "name": "monocyte-derived neutrophil-activating peptide",
                    "type": "synonym"
                },
                {
                    "name": "neutrophil-activating peptide 1",
                    "type": "synonym"
                },
                {
                    "name": "small inducible cytokine subfamily B, member 8",
                    "type": "synonym"
                },
                {
                    "name": "tumor necrosis factor-induced gene 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CXCL8",
                    "type": "recommended"
                },
                {
                    "name": "CXCL8",
                    "type": "synonym"
                },
                {
                    "name": "GCP-1",
                    "type": "synonym"
                },
                {
                    "name": "GCP1",
                    "type": "synonym"
                },
                {
                    "name": "IL8",
                    "type": "synonym"
                },
                {
                    "name": "LECT",
                    "type": "synonym"
                },
                {
                    "name": "LUCT",
                    "type": "synonym"
                },
                {
                    "name": "LYNAP",
                    "type": "synonym"
                },
                {
                    "name": "MDNCF",
                    "type": "synonym"
                },
                {
                    "name": "MONAP",
                    "type": "synonym"
                },
                {
                    "name": "NAF",
                    "type": "synonym"
                },
                {
                    "name": "NAP-1",
                    "type": "synonym"
                },
                {
                    "name": "NAP1",
                    "type": "synonym"
                },
                {
                    "name": "SCYB8",
                    "type": "synonym"
                }
            ],
            "record_id": "P10145-1",
            "evidence": [
                {
                    "id": "0080810",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080810"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9Y271-1",
            "uniprot_ac": "Q9Y271",
            "uniprot_id": "CLTR1_HUMAN",
            "refseq_ac": "NP_001269115",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cysteinyl leukotriene receptor 1",
                    "type": "recommended"
                },
                {
                    "name": "CysLTR1",
                    "type": "synonym"
                },
                {
                    "name": "Cysteinyl leukotriene D4 receptor",
                    "type": "synonym"
                },
                {
                    "name": "G protein-coupled receptor HG55",
                    "type": "synonym"
                },
                {
                    "name": "G-protein coupled receptor HG55",
                    "type": "synonym"
                },
                {
                    "name": "HMTMF81",
                    "type": "synonym"
                },
                {
                    "name": "LTD4 receptor",
                    "type": "synonym"
                },
                {
                    "name": "cysteinyl leukotriene D4 receptor",
                    "type": "synonym"
                },
                {
                    "name": "cysteinyl leukotriene receptor 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CYSLTR1",
                    "type": "recommended"
                },
                {
                    "name": "CYSLT1R",
                    "type": "synonym"
                },
                {
                    "name": "CYSLT1",
                    "type": "synonym"
                },
                {
                    "name": "CYSLTR1",
                    "type": "synonym"
                },
                {
                    "name": "CYSLTR",
                    "type": "synonym"
                },
                {
                    "name": "HMTMF81",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9Y271-1",
            "evidence": [
                {
                    "id": "0080810",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080810"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0080810"
}