{
    "disease_id": "DOID:0080784",
    "recommended_name": {
        "id": "DOID:0080784",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080784",
        "name": "urinary tract infection",
        "description": "An urinary system disease that is characterized by an infection in any part of the urinary system, including the kidneys, ureters, bladder or urethra."
    },
    "synonyms": [
        {
            "id": "DOID:0080784",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080784",
            "name": "UTI",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0080784"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080784",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080784",
            "categories": []
        }
    ],
    "proteins": [
        {
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            "uniprot_ac": "A0A8M1NE33",
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                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "Heat shock cognate 71 kDa protein",
                    "type": "recommended"
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                {
                    "name": "Heat shock 70 kDa protein-like",
                    "type": "synonym"
                }
            ],
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                    "name": "hspa1b",
                    "type": "recommended"
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                    "type": "synonym"
                },
                {
                    "name": "si:ch211-199o1.2",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080784",
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                }
            ]
        },
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                {
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                }
            ],
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                    "name": "Toll-like receptor 4",
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            ],
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                    "name": "tlr4ba",
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                    "name": "tlr4a",
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                    "name": "Danio rerio",
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                }
            ],
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                {
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                    "type": "recommended"
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                {
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                    "id": "0080784",
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                }
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                    "name": "CXCL8bb",
                    "type": "synonym"
                },
                {
                    "name": "Interleukin-8b.1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "cxcl8_l2_chr17",
                    "type": "synonym"
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                    "name": "il8l2",
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                },
                {
                    "name": "interleukin-8, like 1",
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                {
                    "name": "interleukin-8b.1 precursor",
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                    "name": "Danio rerio",
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                }
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                    "name": "Growth-regulated alpha protein isoform X1",
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                {
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                    "type": "synonym"
                }
            ],
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                {
                    "name": "cxcl8a",
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                    "name": "cxcl8a",
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                {
                    "id": "0080784",
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                    "name": "Danio rerio",
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                }
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                {
                    "name": "Interleukin-1",
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                {
                    "name": "interleukin-1 beta isoform X1",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "il1b",
                    "type": "recommended"
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                {
                    "name": "il1-b",
                    "type": "synonym"
                },
                {
                    "name": "il1b",
                    "type": "synonym"
                },
                {
                    "name": "zgc:111873",
                    "type": "synonym"
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            ],
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                {
                    "id": "0080784",
                    "database": "AGR",
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                }
            ]
        },
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            "uniprot_canonical_ac": "Q810W6-1",
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                {
                    "name": "Mus musculus",
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                    "glygen_name": "Mouse",
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                }
            ],
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                    "name": "C-X-C chemokine receptor type 1",
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                    "name": "C-X-C chemokine receptor type 1",
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                {
                    "name": "CXC chemokine receptor 1",
                    "type": "synonym"
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                    "name": "CXC-R1",
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                    "name": "CXCR-1",
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                    "name": "High affinity interleukin-8 receptor A",
                    "type": "synonym"
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                    "name": "IL-8R A",
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                    "name": "chemokine (C-X-C motif) receptor 1",
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                    "name": "high affinity interleukin-8 receptor A",
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                    "name": "interleukin 8 receptor, alpha",
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                    "name": "Il8ra",
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                    "id": "0080784",
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                    "id": "0080784",
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                    "id": "0080784",
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                    "name": "IL-1 beta",
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                },
                {
                    "name": "dhsc70",
                    "type": "synonym"
                },
                {
                    "name": "hsc70",
                    "type": "synonym"
                }
            ],
            "record_id": "P29843-1",
            "evidence": [
                {
                    "id": "0080784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080784"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P08953-1",
            "uniprot_ac": "P08953",
            "uniprot_id": "TOLL_DROME",
            "refseq_ac": "NP_524518",
            "glycoprotein": "yes",
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                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Protein toll",
                    "type": "recommended"
                },
                {
                    "name": "CG5490-PB",
                    "type": "synonym"
                },
                {
                    "name": "EP1051",
                    "type": "synonym"
                },
                {
                    "name": "TOLL",
                    "type": "synonym"
                },
                {
                    "name": "Tl-PB",
                    "type": "synonym"
                },
                {
                    "name": "Toll-1",
                    "type": "synonym"
                },
                {
                    "name": "protein toll precursor",
                    "type": "synonym"
                },
                {
                    "name": "toll receptor",
                    "type": "synonym"
                },
                {
                    "name": "toll, isoform B",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tl",
                    "type": "recommended"
                },
                {
                    "name": "CG5490",
                    "type": "synonym"
                },
                {
                    "name": "CT17414",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG5490",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG5490",
                    "type": "synonym"
                },
                {
                    "name": "EP(3)1051",
                    "type": "synonym"
                },
                {
                    "name": "EP1051",
                    "type": "synonym"
                },
                {
                    "name": "Fs(1)Tl",
                    "type": "synonym"
                },
                {
                    "name": "Fs(3)Tl",
                    "type": "synonym"
                },
                {
                    "name": "T1",
                    "type": "synonym"
                },
                {
                    "name": "TL",
                    "type": "synonym"
                },
                {
                    "name": "TOLL",
                    "type": "synonym"
                },
                {
                    "name": "TOL",
                    "type": "synonym"
                },
                {
                    "name": "Tl",
                    "type": "synonym"
                },
                {
                    "name": "Toll-1",
                    "type": "synonym"
                },
                {
                    "name": "Toll10B",
                    "type": "synonym"
                },
                {
                    "name": "Toll1",
                    "type": "synonym"
                },
                {
                    "name": "dToll1",
                    "type": "synonym"
                },
                {
                    "name": "dToll",
                    "type": "synonym"
                },
                {
                    "name": "mat(3)9",
                    "type": "synonym"
                },
                {
                    "name": "mel(3)10",
                    "type": "synonym"
                },
                {
                    "name": "mel(3)9",
                    "type": "synonym"
                },
                {
                    "name": "tl",
                    "type": "synonym"
                },
                {
                    "name": "toll-1",
                    "type": "synonym"
                },
                {
                    "name": "toll",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080784"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VJX9-1",
            "uniprot_ac": "Q9VJX9",
            "uniprot_id": "Q9VJX9_DROME",
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                {
                    "name": "Drosophila melanogaster",
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                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG7121-PB",
                    "type": "synonym"
                },
                {
                    "name": "Tehao, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "Tehao, isoform B",
                    "type": "synonym"
                },
                {
                    "name": "Tehao-PB",
                    "type": "synonym"
                },
                {
                    "name": "Toll-5",
                    "type": "synonym"
                },
                {
                    "name": "tehao, isoform B",
                    "type": "synonym"
                },
                {
                    "name": "toll 5",
                    "type": "synonym"
                },
                {
                    "name": "toll receptor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tehao",
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                },
                {
                    "name": "CG7121",
                    "type": "synonym"
                },
                {
                    "name": "CT22017",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG7121",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG7121",
                    "type": "synonym"
                },
                {
                    "name": "Tehao",
                    "type": "synonym"
                },
                {
                    "name": "Tho",
                    "type": "synonym"
                },
                {
                    "name": "Tl-5",
                    "type": "synonym"
                },
                {
                    "name": "Toll 5",
                    "type": "synonym"
                },
                {
                    "name": "Toll-5",
                    "type": "synonym"
                },
                {
                    "name": "Toll5",
                    "type": "synonym"
                },
                {
                    "name": "dTLR5",
                    "type": "synonym"
                },
                {
                    "name": "dToll5",
                    "type": "synonym"
                },
                {
                    "name": "tehao",
                    "type": "synonym"
                },
                {
                    "name": "toll",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VJX9-1",
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                {
                    "id": "0080784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080784"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VPH1-1",
            "uniprot_ac": "Q9VPH1",
            "uniprot_id": "Q9VPH1_DROME",
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            "glycoprotein": "no",
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                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
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                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG5528-PC",
                    "type": "synonym"
                },
                {
                    "name": "Toll-9, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "Toll-9, isoform C",
                    "type": "synonym"
                },
                {
                    "name": "Toll-9-PC",
                    "type": "synonym"
                },
                {
                    "name": "toll receptor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Toll-9",
                    "type": "recommended"
                },
                {
                    "name": "CG5528",
                    "type": "synonym"
                },
                {
                    "name": "CT17508",
                    "type": "synonym"
                },
                {
                    "name": "Dm Toll-9",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG5528",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG5528",
                    "type": "synonym"
                },
                {
                    "name": "TOLL 9",
                    "type": "synonym"
                },
                {
                    "name": "Tak/Toll-like",
                    "type": "synonym"
                },
                {
                    "name": "Tl-5",
                    "type": "synonym"
                },
                {
                    "name": "Tl-9",
                    "type": "synonym"
                },
                {
                    "name": "Toll 9",
                    "type": "synonym"
                },
                {
                    "name": "Toll-6",
                    "type": "synonym"
                },
                {
                    "name": "Toll-9",
                    "type": "synonym"
                },
                {
                    "name": "Toll-like",
                    "type": "synonym"
                },
                {
                    "name": "Toll9",
                    "type": "synonym"
                },
                {
                    "name": "Toll",
                    "type": "synonym"
                },
                {
                    "name": "dTLR9",
                    "type": "synonym"
                },
                {
                    "name": "dToll9",
                    "type": "synonym"
                },
                {
                    "name": "toll",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VPH1-1",
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                {
                    "id": "0080784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080784"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O94907-1",
            "uniprot_ac": "O94907",
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "Dickkopf-related protein 1",
                    "type": "recommended"
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                {
                    "name": "Dickkopf-1",
                    "type": "synonym"
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                {
                    "name": "Dkk-1",
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                },
                {
                    "name": "SK",
                    "type": "synonym"
                },
                {
                    "name": "dickkopf 1 homolog",
                    "type": "synonym"
                },
                {
                    "name": "dickkopf-1 like",
                    "type": "synonym"
                },
                {
                    "name": "dickkopf-like protein 1",
                    "type": "synonym"
                },
                {
                    "name": "dickkopf-related protein 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "dickkopf-related protein 1",
                    "type": "synonym"
                },
                {
                    "name": "hDkk-1",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "DKK1",
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                {
                    "name": "DKK-1",
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                },
                {
                    "name": "DKK1",
                    "type": "synonym"
                },
                {
                    "name": "PRO1008",
                    "type": "synonym"
                },
                {
                    "name": "SK",
                    "type": "synonym"
                }
            ],
            "record_id": "O94907-1",
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                {
                    "id": "0080784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080784"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O60832-1",
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                    "name": "Homo sapiens",
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "H/ACA ribonucleoprotein complex subunit DKC1",
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                {
                    "name": "5.4.99.-",
                    "type": "synonym"
                },
                {
                    "name": "CBF5 homolog",
                    "type": "synonym"
                },
                {
                    "name": "Dyskerin",
                    "type": "synonym"
                },
                {
                    "name": "H/ACA ribonucleoprotein complex subunit 4",
                    "type": "synonym"
                },
                {
                    "name": "H/ACA ribonucleoprotein complex subunit DKC1 isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "H/ACA ribonucleoprotein complex subunit DKC1",
                    "type": "synonym"
                },
                {
                    "name": "Nopp140-associated protein of 57 kDa",
                    "type": "synonym"
                },
                {
                    "name": "Nucleolar protein NAP57",
                    "type": "synonym"
                },
                {
                    "name": "Nucleolar protein family A member 4",
                    "type": "synonym"
                },
                {
                    "name": "dyskeratosis congenita 1, dyskerin",
                    "type": "synonym"
                },
                {
                    "name": "nopp140-associated protein of 57 kDa",
                    "type": "synonym"
                },
                {
                    "name": "nucleolar protein NAP57",
                    "type": "synonym"
                },
                {
                    "name": "nucleolar protein family A member 4",
                    "type": "synonym"
                },
                {
                    "name": "snoRNP protein DKC1",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "DKC1",
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                {
                    "name": "CBF5",
                    "type": "synonym"
                },
                {
                    "name": "CHINE1",
                    "type": "synonym"
                },
                {
                    "name": "DKC1",
                    "type": "synonym"
                },
                {
                    "name": "DKCX",
                    "type": "synonym"
                },
                {
                    "name": "DKC",
                    "type": "synonym"
                },
                {
                    "name": "NAP57",
                    "type": "synonym"
                },
                {
                    "name": "NOLA4",
                    "type": "synonym"
                },
                {
                    "name": "XAP101",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080784"
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            ]
        },
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            "uniprot_canonical_ac": "O14490-1",
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                    "name": "Homo sapiens",
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "Disks large-associated protein 1",
                    "type": "recommended"
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                {
                    "name": "DAP-1",
                    "type": "synonym"
                },
                {
                    "name": "Guanylate kinase-associated protein",
                    "type": "synonym"
                },
                {
                    "name": "PSD-95/SAP90 binding protein 1",
                    "type": "synonym"
                },
                {
                    "name": "PSD-95/SAP90-binding protein 1",
                    "type": "synonym"
                },
                {
                    "name": "SAP90/PSD-95-associated protein 1",
                    "type": "synonym"
                },
                {
                    "name": "SAPAP1",
                    "type": "synonym"
                },
                {
                    "name": "discs large homolog associated protein 1",
                    "type": "synonym"
                },
                {
                    "name": "disks large-associated protein 1 isoform 5",
                    "type": "synonym"
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                {
                    "name": "disks large-associated protein 1",
                    "type": "synonym"
                },
                {
                    "name": "guanylate kinase-associated protein",
                    "type": "synonym"
                },
                {
                    "name": "hGKAP",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "DLGAP1",
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                {
                    "name": "DAP-1-ALPHA",
                    "type": "synonym"
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                {
                    "name": "DAP-1-BETA",
                    "type": "synonym"
                },
                {
                    "name": "DAP-1",
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                },
                {
                    "name": "DAP1",
                    "type": "synonym"
                },
                {
                    "name": "DLGAP1A",
                    "type": "synonym"
                },
                {
                    "name": "DLGAP1B",
                    "type": "synonym"
                },
                {
                    "name": "DLGAP1",
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                },
                {
                    "name": "GKAP",
                    "type": "synonym"
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                {
                    "name": "SAPAP1",
                    "type": "synonym"
                }
            ],
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                    "id": "0080784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080784"
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            ]
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            "uniprot_canonical_ac": "P80188-1",
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                    "name": "Homo sapiens",
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "Neutrophil gelatinase-associated lipocalin",
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                {
                    "name": "25 kDa alpha-2-microglobulin-related subunit of MMP-9",
                    "type": "synonym"
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                {
                    "name": "Lipocalin-2",
                    "type": "synonym"
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                {
                    "name": "NGAL",
                    "type": "synonym"
                },
                {
                    "name": "Oncogene 24p3",
                    "type": "synonym"
                },
                {
                    "name": "Siderocalin",
                    "type": "synonym"
                },
                {
                    "name": "migration-stimulating factor inhibitor",
                    "type": "synonym"
                },
                {
                    "name": "neutrophil gelatinase-associated lipocalin precursor",
                    "type": "synonym"
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                {
                    "name": "neutrophil gelatinase-associated lipocalin",
                    "type": "synonym"
                },
                {
                    "name": "oncogene 24p3",
                    "type": "synonym"
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                {
                    "name": "p25",
                    "type": "synonym"
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                {
                    "name": "siderocalin LCN2",
                    "type": "synonym"
                }
            ],
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                    "name": "LCN2",
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                {
                    "name": "24p3",
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                },
                {
                    "name": "HNL",
                    "type": "synonym"
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                {
                    "name": "LCN2",
                    "type": "synonym"
                },
                {
                    "name": "MSFI",
                    "type": "synonym"
                },
                {
                    "name": "NGAL",
                    "type": "synonym"
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                {
                    "name": "p25",
                    "type": "synonym"
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                {
                    "id": "0080784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080784"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P10145-1",
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                    "name": "Homo sapiens",
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                    "common_name": "Human",
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "Interleukin-8",
                    "type": "recommended"
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                {
                    "name": "(Ala-IL-8)77",
                    "type": "synonym"
                },
                {
                    "name": "(Ser-IL-8)72",
                    "type": "synonym"
                },
                {
                    "name": "C-X-C motif chemokine 8",
                    "type": "synonym"
                },
                {
                    "name": "Chemokine (C-X-C motif) ligand 8",
                    "type": "synonym"
                },
                {
                    "name": "Emoctakin",
                    "type": "synonym"
                },
                {
                    "name": "GCP-1",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein III",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein II",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein IV",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein I",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein VI",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein V",
                    "type": "synonym"
                },
                {
                    "name": "Granulocyte chemotactic protein 1",
                    "type": "synonym"
                },
                {
                    "name": "IL-8(1-77)",
                    "type": "synonym"
                },
                {
                    "name": "IL-8",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form III",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form II",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form IV",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form I",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form VI",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form V",
                    "type": "synonym"
                },
                {
                    "name": "LYNAP",
                    "type": "synonym"
                },
                {
                    "name": "Lymphocyte-derived neutrophil-activating factor",
                    "type": "synonym"
                },
                {
                    "name": "MDNCF-b",
                    "type": "synonym"
                },
                {
                    "name": "MDNCF-c",
                    "type": "synonym"
                },
                {
                    "name": "MDNCF",
                    "type": "synonym"
                },
                {
                    "name": "MONAP",
                    "type": "synonym"
                },
                {
                    "name": "Monocyte-derived neutrophil chemotactic factor",
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                {
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                    "name": "NAF",
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                    "name": "NAP-1",
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                    "name": "Neutrophil-activating factor",
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                {
                    "name": "Neutrophil-activating protein 1",
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                },
                {
                    "name": "Protein 3-10C",
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                    "name": "T-cell chemotactic factor",
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                    "name": "alveolar macrophage chemotactic factor I",
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                {
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                    "name": "beta-thromboglobulin-like protein",
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                    "name": "granulocyte chemotactic protein 1",
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                {
                    "name": "interleukin 8",
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                {
                    "name": "interleukin-8 isoform 1 precursor",
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                {
                    "name": "lung giant cell carcinoma-derived chemotactic protein",
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                {
                    "name": "lymphocyte derived neutrophil activating peptide",
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                    "name": "monocyte-derived neutrophil-activating peptide",
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                {
                    "name": "neutrophil-activating peptide 1",
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                {
                    "name": "small inducible cytokine subfamily B, member 8",
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                    "name": "GCP1",
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}