{
    "disease_id": "DOID:0080361",
    "recommended_name": {
        "id": "DOID:0080361",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080361",
        "name": "trimethylaminuria",
        "description": "An inherited metabolic disorder characterized by the inability to break down trimethylamine and has_material_basis_in homozygous or compound heterozygous mutation in the gene encoding flavin-containing monooxygenase-3 on chromosome 1q24."
    },
    "synonyms": [
        {
            "id": "DOID:0080361",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080361",
            "name": "fish-odor syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0018767",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0018767",
            "name": "severe primary trimethylaminuria",
            "description": "Any trimethylaminuria in which the cause of the disease is a mutation in the FMO3 gene."
        },
        {
            "id": "MONDO:0018767",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0018767",
            "name": "trimethylaminuria",
            "description": ""
        },
        {
            "id": "MONDO:0018767",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0018767",
            "name": "TMAU",
            "description": ""
        },
        {
            "id": "MONDO:0018767",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0018767",
            "name": "TMAuria",
            "description": ""
        },
        {
            "id": "MONDO:0018767",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0018767",
            "name": "fish malodor syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0018767",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0018767",
            "name": "fish odor syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0018767",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0018767",
            "name": "fish odour syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0018767",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0018767",
            "name": "stale fish syndrome",
            "description": ""
        },
        {
            "id": "MIM:602079",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/602079",
            "name": "Trimethylaminuria",
            "description": "Trimethylaminuria"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0080361"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080361",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080361",
            "categories": []
        },
        {
            "id": "MONDO:0018767",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0018767",
            "categories": []
        },
        {
            "id": "MIM:602079",
            "database": "MIM",
            "url": "https://www.omim.org/entry/602079",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q5TZD3-1",
            "uniprot_ac": "Q5TZD3",
            "uniprot_id": "Q5TZD3_DANRE",
            "refseq_ac": "NP_001038294",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Flavin-containing monooxygenase",
                    "type": "recommended"
                },
                {
                    "name": "1.-.-.-",
                    "type": "synonym"
                },
                {
                    "name": "si:dkey-239i20.2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "si:dkey-239i20.2",
                    "type": "recommended"
                },
                {
                    "name": "si:ch211-191d7.2",
                    "type": "synonym"
                },
                {
                    "name": "si:dkey-239i20.2",
                    "type": "synonym"
                },
                {
                    "name": "zgc:171329",
                    "type": "synonym"
                }
            ],
            "record_id": "Q5TZD3-1",
            "evidence": [
                {
                    "id": "0080361",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080361"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0AA53ECJ5-1",
            "uniprot_ac": "A0AA53ECJ5",
            "uniprot_id": "A0AA53ECJ5_DANRE",
            "refseq_ac": "XP_005160478",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Flavin-containing monooxygenase",
                    "type": "recommended"
                },
                {
                    "name": "1.-.-.-",
                    "type": "synonym"
                },
                {
                    "name": "si:dkey-239i20.4 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "si:dkey-239i20.4",
                    "type": "recommended"
                },
                {
                    "name": "fc14c11",
                    "type": "synonym"
                },
                {
                    "name": "si:dkey-239i20.4",
                    "type": "synonym"
                },
                {
                    "name": "wu:fc14c11",
                    "type": "synonym"
                },
                {
                    "name": "zgc:153645",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AA53ECJ5-1",
            "evidence": [
                {
                    "id": "0080361",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080361"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P97501-1",
            "uniprot_ac": "P97501",
            "uniprot_id": "FMO3_MOUSE",
            "refseq_ac": "NP_032056",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Flavin-containing monooxygenase 3",
                    "type": "recommended"
                },
                {
                    "name": "1.14.13.148",
                    "type": "synonym"
                },
                {
                    "name": "1.14.13.32",
                    "type": "synonym"
                },
                {
                    "name": "1.14.13.8",
                    "type": "synonym"
                },
                {
                    "name": "Dimethylaniline monooxygenase [N-oxide-forming] 3",
                    "type": "synonym"
                },
                {
                    "name": "Dimethylaniline oxidase 3",
                    "type": "synonym"
                },
                {
                    "name": "FMO 3",
                    "type": "synonym"
                },
                {
                    "name": "Hepatic flavin-containing monooxygenase 3",
                    "type": "synonym"
                },
                {
                    "name": "Trimethylamine monooxygenase",
                    "type": "synonym"
                },
                {
                    "name": "dimethylaniline monooxygenase [N-oxide-forming] 3",
                    "type": "synonym"
                },
                {
                    "name": "dimethylaniline oxidase 3",
                    "type": "synonym"
                },
                {
                    "name": "flavin-containing monooxygenase 3",
                    "type": "synonym"
                },
                {
                    "name": "hepatic flavin-containing monooxygenase 3",
                    "type": "synonym"
                },
                {
                    "name": "trimethylamine monooxygenase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Fmo3",
                    "type": "recommended"
                },
                {
                    "name": "Fmo3",
                    "type": "synonym"
                }
            ],
            "record_id": "P97501-1",
            "evidence": [
                {
                    "id": "0080361",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080361"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P31513-1",
            "uniprot_ac": "P31513",
            "uniprot_id": "FMO3_HUMAN",
            "refseq_ac": "NP_001002294",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Flavin-containing monooxygenase 3",
                    "type": "recommended"
                },
                {
                    "name": "1.14.13.148",
                    "type": "synonym"
                },
                {
                    "name": "1.14.13.32",
                    "type": "synonym"
                },
                {
                    "name": "1.14.13.8",
                    "type": "synonym"
                },
                {
                    "name": "Dimethylaniline monooxygenase [N-oxide-forming] 3",
                    "type": "synonym"
                },
                {
                    "name": "Dimethylaniline oxidase 3",
                    "type": "synonym"
                },
                {
                    "name": "FMO 3",
                    "type": "synonym"
                },
                {
                    "name": "FMO II",
                    "type": "synonym"
                },
                {
                    "name": "FMO form 2",
                    "type": "synonym"
                },
                {
                    "name": "Hepatic flavin-containing monooxygenase 3",
                    "type": "synonym"
                },
                {
                    "name": "Trimethylamine monooxygenase",
                    "type": "synonym"
                },
                {
                    "name": "dimethylaniline monooxygenase [N-oxide-forming] 3",
                    "type": "synonym"
                },
                {
                    "name": "dimethylaniline oxidase 3",
                    "type": "synonym"
                },
                {
                    "name": "flavin containing monooxygenase 3",
                    "type": "synonym"
                },
                {
                    "name": "flavin-containing monooxygenase 3 isoform a",
                    "type": "synonym"
                },
                {
                    "name": "hepatic flavin-containing monooxygenase-3",
                    "type": "synonym"
                },
                {
                    "name": "trimethylamine monooxygenase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "FMO3",
                    "type": "recommended"
                },
                {
                    "name": "FMO3",
                    "type": "synonym"
                },
                {
                    "name": "FMOII",
                    "type": "synonym"
                },
                {
                    "name": "TMAU",
                    "type": "synonym"
                },
                {
                    "name": "dJ127D3.1",
                    "type": "synonym"
                }
            ],
            "record_id": "P31513-1",
            "evidence": [
                {
                    "id": "602079",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/602079"
                },
                {
                    "id": "0080361",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080361"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P38866-1",
            "uniprot_ac": "P38866",
            "uniprot_id": "FMO1_YEAST",
            "refseq_ac": "NP_012046",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Thiol-specific monooxygenase",
                    "type": "recommended"
                },
                {
                    "name": "1.14.13.-",
                    "type": "synonym"
                },
                {
                    "name": "Flavin-dependent monooxygenase",
                    "type": "synonym"
                },
                {
                    "name": "N,N-dimethylaniline monooxygenase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "FMO1",
                    "type": "recommended"
                },
                {
                    "name": "FMO1",
                    "type": "synonym"
                }
            ],
            "record_id": "P38866-1",
            "evidence": [
                {
                    "id": "0080361",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080361"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9EQ76-1",
            "uniprot_ac": "Q9EQ76",
            "uniprot_id": "FMO3_RAT",
            "refseq_ac": "NP_445885",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Flavin-containing monooxygenase 3",
                    "type": "recommended"
                },
                {
                    "name": "1.14.13.148",
                    "type": "synonym"
                },
                {
                    "name": "1.14.13.32",
                    "type": "synonym"
                },
                {
                    "name": "1.14.13.8",
                    "type": "synonym"
                },
                {
                    "name": "Dimethylaniline monooxygenase [N-oxide-forming] 3",
                    "type": "synonym"
                },
                {
                    "name": "Dimethylaniline oxidase 3",
                    "type": "synonym"
                },
                {
                    "name": "FMO 3",
                    "type": "synonym"
                },
                {
                    "name": "Hepatic flavin-containing monooxygenase 3",
                    "type": "synonym"
                },
                {
                    "name": "Trimethylamine monooxygenase",
                    "type": "synonym"
                },
                {
                    "name": "dimethylaniline monooxygenase [N-oxide-forming] 3",
                    "type": "synonym"
                },
                {
                    "name": "dimethylaniline oxidase 3",
                    "type": "synonym"
                },
                {
                    "name": "flavin containing monooxygenase 3",
                    "type": "synonym"
                },
                {
                    "name": "flavin-containing monooxygenase 3",
                    "type": "synonym"
                },
                {
                    "name": "hepatic flavin-containing monooxygenase 3",
                    "type": "synonym"
                },
                {
                    "name": "trimethylamine monooxygenase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Fmo3",
                    "type": "recommended"
                },
                {
                    "name": "Fmo3",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9EQ76-1",
            "evidence": [
                {
                    "id": "0080361",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080361"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "F1M9D6-1",
            "uniprot_ac": "F1M9D6",
            "uniprot_id": "F1M9D6_RAT",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Signal transducer and activator of transcription",
                    "type": "recommended"
                }
            ],
            "gene_names": [
                {
                    "name": "Stat1",
                    "type": "recommended"
                },
                {
                    "name": "Stat4",
                    "type": "synonym"
                }
            ],
            "record_id": "F1M9D6-1",
            "evidence": [
                {
                    "id": "0080361",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080361"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9W1E9-1",
            "uniprot_ac": "Q9W1E9",
            "uniprot_id": "Q9W1E9_DROME",
            "refseq_ac": "NP_611859",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Flavin-containing monooxygenase",
                    "type": "recommended"
                },
                {
                    "name": "1.-.-.-",
                    "type": "synonym"
                },
                {
                    "name": "CG3006-PA",
                    "type": "synonym"
                },
                {
                    "name": "Flavin-containing monooxygenase 1",
                    "type": "synonym"
                },
                {
                    "name": "Fmo-1-PA",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Fmo1",
                    "type": "recommended"
                },
                {
                    "name": "CG3006",
                    "type": "synonym"
                },
                {
                    "name": "DmFMO-1",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG3006",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG3006",
                    "type": "synonym"
                },
                {
                    "name": "Dmfmo1",
                    "type": "synonym"
                },
                {
                    "name": "FMO-1",
                    "type": "synonym"
                },
                {
                    "name": "Fmo-1",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9W1E9-1",
            "evidence": [
                {
                    "id": "0080361",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080361"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0080361"
}