{
    "disease_id": "DOID:0070227",
    "recommended_name": {
        "id": "DOID:0070227",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0070227",
        "name": "intrahepatic cholestasis of pregnancy",
        "description": "An intrahepatic cholestasis characterized by reversible cholestasis typically occurring in the second or third trimester of pregnancy, elevated serum aminotransferases and bile acid level and resolution of symptoms by 2 to 3 weeks after delivery."
    },
    "synonyms": [
        {
            "id": "DOID:0070227",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070227",
            "name": "ICP",
            "description": ""
        },
        {
            "id": "DOID:0070227",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070227",
            "name": "gravidic intrahepatic cholestasis",
            "description": ""
        },
        {
            "id": "DOID:0070227",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070227",
            "name": "pregnancy related cholestasis",
            "description": ""
        },
        {
            "id": "DOID:0070227",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070227",
            "name": "recurrent intrahepatic cholestasis of pregnancy",
            "description": ""
        }
    ],
    "children": [
        {
            "id": "DOID:0070228",
            "label": "intrahepatic cholestasis of pregnancy 1",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:0070229",
            "label": "intrahepatic cholestasis of pregnancy 3",
            "link_status": true,
            "children": []
        }
    ],
    "id_list": [
        "DOID:0070228",
        "DOID:0070229",
        "DOID:0070227"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0070227",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070227",
            "categories": []
        }
    ],
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        {
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            "uniprot_ac": "Q803C3",
            "uniprot_id": "HDAC3_DANRE",
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            "glycoprotein": "no",
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                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                    "name": "Histone deacetylase 3",
                    "type": "recommended"
                },
                {
                    "name": "3.5.1.-",
                    "type": "synonym"
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                {
                    "name": "3.5.1.98",
                    "type": "synonym"
                },
                {
                    "name": "HD3",
                    "type": "synonym"
                },
                {
                    "name": "Protein deacetylase HDAC3",
                    "type": "synonym"
                },
                {
                    "name": "Protein deacylase HDAC3",
                    "type": "synonym"
                },
                {
                    "name": "histone deacetylase 3",
                    "type": "synonym"
                },
                {
                    "name": "protein deacetylase HDAC3",
                    "type": "synonym"
                },
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                    "name": "protein deacylase HDAC3",
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                }
            ],
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                    "name": "hdac3",
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                },
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                    "name": "hdac3",
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                {
                    "name": "zgc:55927",
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                }
            ],
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                    "id": "0070227",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0070227"
                }
            ]
        },
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            "uniprot_canonical_ac": "P70380-1",
            "uniprot_ac": "P70380",
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                {
                    "name": "Mus musculus",
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                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                    "name": "Interleukin-18",
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                },
                {
                    "name": "IFN-gamma-inducing factor",
                    "type": "synonym"
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                    "name": "IL-1 gamma",
                    "type": "synonym"
                },
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                    "name": "IL-18",
                    "type": "synonym"
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                    "name": "Interferon gamma-inducing factor",
                    "type": "synonym"
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                    "name": "Interleukin-1 gamma",
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                    "name": "interleukin-1 gamma",
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                    "name": "interleukin-18 isoform a",
                    "type": "synonym"
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                    "name": "Il18",
                    "type": "recommended"
                },
                {
                    "name": "Igif",
                    "type": "synonym"
                },
                {
                    "name": "Il-18",
                    "type": "synonym"
                },
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                    "name": "Il18",
                    "type": "synonym"
                }
            ],
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                    "id": "0070227",
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                }
            ]
        },
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            "uniprot_canonical_ac": "O88895-1",
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                    "glygen_name": "Mouse",
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                }
            ],
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                    "name": "Histone deacetylase 3",
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                {
                    "name": "HDAC3 splicing HDAC3alpha",
                    "type": "synonym"
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                    "name": "HDAC3 splicing HDAC3beta",
                    "type": "synonym"
                },
                {
                    "name": "HDAC3 splicing HDAC3delta",
                    "type": "synonym"
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                {
                    "name": "HDAC3 splicing HDAC3gamma",
                    "type": "synonym"
                },
                {
                    "name": "Protein deacetylase HDAC3",
                    "type": "synonym"
                },
                {
                    "name": "Protein deacylase HDAC3",
                    "type": "synonym"
                },
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                    "name": "histone deacetylase 3",
                    "type": "synonym"
                },
                {
                    "name": "protein deacetylase HDAC3",
                    "type": "synonym"
                },
                {
                    "name": "protein deacylase HDAC3",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Hdac3",
                    "type": "recommended"
                },
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            ],
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                    "id": "0070227",
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                }
            ]
        },
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            "uniprot_ac": "P53096",
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                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
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                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
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                {
                    "name": "Probable histone deacetylase HOS2",
                    "type": "recommended"
                },
                {
                    "name": "3.5.1.98",
                    "type": "synonym"
                },
                {
                    "name": "histone deacetylase HOS2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "HOS2",
                    "type": "recommended"
                },
                {
                    "name": "G1330",
                    "type": "synonym"
                },
                {
                    "name": "HOS2",
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                },
                {
                    "name": "RTL1",
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            ],
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                {
                    "id": "0070227",
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                }
            ]
        },
        {
            "uniprot_canonical_ac": "P97636-1",
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            "refseq_ac": "",
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                {
                    "name": "Rattus norvegicus",
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                }
            ],
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                    "name": "Interferon gamma-inducing factor",
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            ],
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                    "name": "Igif",
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                    "id": "0070227",
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                    "name": "Protein deacetylase HDAC3",
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                    "name": "histone deacetylase subfamily 1",
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                    "name": "Drosophila melanogaster",
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                    "name": "Hdac3",
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                    "name": "histone Deacetylase-3",
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                    "name": "dHDAC3",
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                    "name": "dmHDA402",
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                    "name": "hdac3",
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                    "id": "0070227",
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            "uniprot_canonical_ac": "O15379-1",
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                    "name": "Protein deacetylase HDAC3",
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                    "name": "Protein deacylase HDAC3",
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                    "name": "RPD3-2",
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                    "name": "SMAP45",
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                    "name": "protein deacetylase HDAC3",
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                    "name": "HDAC3",
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                    "id": "0070227",
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                    "name": "IL-18",
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                    "name": "Iboctadekin",
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                    "name": "Interferon gamma-inducing factor",
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                    "name": "Interleukin-1 gamma",
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                    "name": "iboctadekin",
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                    "id": "0070227",
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                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0070227"
}