{
    "disease_id": "DOID:0070028",
    "recommended_name": {
        "id": "DOID:0070028",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0070028",
        "name": "APP-related cerebral amyloid angiopathy",
        "description": "A cerebral amyloid angiopathy that has_material_basis_in an autosomal dominant mutation of APP on chromosome 21q21.3."
    },
    "synonyms": [
        {
            "id": "DOID:0070028",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070028",
            "name": "Cerebral Amyloid Angiopathy, App-Related, Dutch Variant",
            "description": ""
        },
        {
            "id": "DOID:0070028",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070028",
            "name": "Cerebral Amyloid Angiopathy, App-Related, Flemish Variant",
            "description": ""
        },
        {
            "id": "DOID:0070028",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070028",
            "name": "Amyloidosis, Cerebroarterial, App-Related",
            "description": ""
        },
        {
            "id": "DOID:0070028",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070028",
            "name": "HCHWAD",
            "description": ""
        },
        {
            "id": "DOID:0070028",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070028",
            "name": "Cerebral Amyloid Angiopathy, App-Related, Arctic Variant",
            "description": ""
        },
        {
            "id": "DOID:0070028",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070028",
            "name": "Cerebral Amyloid Angiopathy, App-Related, Italian Variant",
            "description": ""
        },
        {
            "id": "DOID:0070028",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070028",
            "name": "Cerebral Amyloid Angiopathy, App-Related, Iowa Variant",
            "description": ""
        },
        {
            "id": "DOID:0070028",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070028",
            "name": "Amyloidosis, Hereditary, With Cerebral Hemorrhage, Dutch Variant",
            "description": ""
        },
        {
            "id": "MONDO:0011583",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011583",
            "name": "cerebral amyloid angiopathy, APP-related",
            "description": "A cerebral amyloid angiopathy that has material basis in an autosomal dominant mutation of APP on chromosome 21q21.3."
        },
        {
            "id": "MONDO:0011583",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011583",
            "name": "HCHWAD",
            "description": ""
        },
        {
            "id": "MONDO:0011583",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011583",
            "name": "amyloidosis, Cerebroarterial, APP-related",
            "description": ""
        },
        {
            "id": "MONDO:0011583",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011583",
            "name": "cerebral amyloid angiopathy, APP-related",
            "description": ""
        },
        {
            "id": "MONDO:0011583",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011583",
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            "description": ""
        },
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            "id": "MIM:605714",
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            "url": "https://www.omim.org/entry/605714",
            "name": "Cerebral amyloid angiopathy, APP-related",
            "description": "Cerebral amyloid angiopathy, APP-related"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0070028"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0070028",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070028",
            "categories": []
        },
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            "id": "MONDO:0011583",
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            "url": "https://monarchinitiative.org/disease/MONDO:0011583",
            "categories": []
        },
        {
            "id": "MIM:605714",
            "database": "MIM",
            "url": "https://www.omim.org/entry/605714",
            "categories": []
        }
    ],
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        {
            "uniprot_canonical_ac": "P12023-1",
            "uniprot_ac": "P12023",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                    "type": "recommended"
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                    "name": "AID(57)",
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                    "type": "synonym"
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                {
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                {
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                {
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                {
                    "name": "Amyloid intracellular domain 57",
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                    "name": "Amyloid intracellular domain 59",
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                    "name": "amyloid-beta precursor protein isoform 1 precursor",
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                    "name": "appican",
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                {
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                {
                    "name": "protease nexin II",
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                    "name": "App",
                    "type": "recommended"
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                    "name": "Adap",
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                    "name": "Ag",
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                    "name": "App",
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                    "name": "Cvap",
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                {
                    "name": "E030013M08Rik",
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                    "name": "betaApp",
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
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                    "glygen_name": "Human",
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                {
                    "name": "AICD-59",
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                    "name": "AID(50)",
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                {
                    "name": "AID(57)",
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                {
                    "name": "AID(59)",
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                {
                    "name": "APPI",
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                    "name": "APP",
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                },
                {
                    "name": "Alpha-CTF",
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                {
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                {
                    "name": "Alzheimer disease amyloid A4 protein homolog",
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                {
                    "name": "Alzheimer disease amyloid protein",
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                {
                    "name": "Amyloid intracellular domain 57",
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                {
                    "name": "Amyloid intracellular domain 59",
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                {
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                {
                    "name": "Amyloid-beta (A4) precursor protein",
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                    "name": "Beta-APP40",
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                {
                    "name": "Beta-APP42",
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                {
                    "name": "Beta-CTF",
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                    "name": "Beta-secretase C-terminal fragment",
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                {
                    "name": "CVAP",
                    "type": "synonym"
                },
                {
                    "name": "Cerebral vascular amyloid peptide",
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                    "name": "PN-II",
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                {
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                {
                    "name": "alzheimer disease amyloid A4 protein homolog",
                    "type": "synonym"
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                {
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                {
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                {
                    "name": "amyloid-beta precursor protein isoform a precursor",
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                {
                    "name": "beta-amyloid peptide(1-40)",
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                    "name": "testicular tissue protein Li 2",
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                    "id": "0070028",
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            "uniprot_canonical_ac": "P08592-1",
            "uniprot_ac": "P08592",
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                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
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                    "name": "Drosophila melanogaster",
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                    "name": "CG7727-PA",
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                {
                    "name": "amyloid Precursor-Like protein",
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                {
                    "name": "amyloid precursor protein like",
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                {
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                    "name": "beta-amyloid-protein-precursor-like",
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                {
                    "name": "BcDNA:GH04413",
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                    "name": "EG:65F1.5",
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                    "name": "appl",
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                    "name": "dAPPL",
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                    "name": "dAPPl",
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                {
                    "name": "dAbeta",
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                    "id": "0070028",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0070028"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0070028"
}