{
    "disease_id": "DOID:0060158",
    "recommended_name": {
        "id": "DOID:0060158",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0060158",
        "name": "acquired metabolic disease",
        "description": "A disease of metabolism that has_material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption."
    },
    "synonyms": [],
    "children": [
        {
            "id": "DOID:0050032",
            "label": "mineral metabolism disease",
            "link_status": false,
            "children": [
                {
                    "id": "DOID:10575",
                    "label": "calcium metabolism disease",
                    "link_status": false,
                    "children": [
                        {
                            "id": "DOID:12678",
                            "label": "hypercalcemia",
                            "link_status": true,
                            "children": [
                                {
                                    "id": "DOID:0060699",
                                    "label": "familial hypocalciuric hypercalcemia",
                                    "link_status": true,
                                    "children": [
                                        {
                                            "id": "DOID:0060700",
                                            "label": "familial hypocalciuric hypercalcemia 1",
                                            "link_status": true,
                                            "children": []
                                        },
                                        {
                                            "id": "DOID:0060701",
                                            "label": "familial hypocalciuric hypercalcemia 2",
                                            "link_status": true,
                                            "children": []
                                        },
                                        {
                                            "id": "DOID:0060702",
                                            "label": "familial hypocalciuric hypercalcemia 3",
                                            "link_status": true,
                                            "children": []
                                        }
                                    ]
                                },
                                {
                                    "id": "DOID:0061135",
                                    "label": "infantile hypercalcemia 2",
                                    "link_status": true,
                                    "children": []
                                },
                                {
                                    "id": "DOID:0061136",
                                    "label": "infantile hypercalcemia 1",
                                    "link_status": true,
                                    "children": []
                                }
                            ]
                        },
                        {
                            "id": "DOID:182",
                            "label": "calcinosis",
                            "link_status": true,
                            "children": [
                                {
                                    "id": "DOID:0080170",
                                    "label": "normophosphatemic familial tumoral calcinosis",
                                    "link_status": true,
                                    "children": []
                                },
                                {
                                    "id": "DOID:0111063",
                                    "label": "hyperphosphatemic familial tumoral calcinosis",
                                    "link_status": true,
                                    "children": []
                                },
                                {
                                    "id": "DOID:6652",
                                    "label": "diffuse idiopathic skeletal hyperostosis",
                                    "link_status": true,
                                    "children": []
                                }
                            ]
                        }
                    ]
                },
                {
                    "id": "DOID:2351",
                    "label": "iron metabolism disease",
                    "link_status": true,
                    "children": [
                        {
                            "id": "DOID:0050711",
                            "label": "aceruloplasminemia",
                            "link_status": true,
                            "children": []
                        },
                        {
                            "id": "DOID:12119",
                            "label": "hemosiderosis",
                            "link_status": true,
                            "children": []
                        }
                    ]
                },
                {
                    "id": "DOID:2485",
                    "label": "phosphorus metabolism disease",
                    "link_status": false,
                    "children": [
                        {
                            "id": "DOID:0050336",
                            "label": "hypophosphatemia",
                            "link_status": true,
                            "children": []
                        },
                        {
                            "id": "DOID:0050459",
                            "label": "hyperphosphatemia",
                            "link_status": true,
                            "children": []
                        }
                    ]
                },
                {
                    "id": "DOID:4500",
                    "label": "hypokalemia",
                    "link_status": true,
                    "children": []
                }
            ]
        },
        {
            "id": "DOID:0050758",
            "label": "metabolic acidosis",
            "link_status": true,
            "children": [
                {
                    "id": "DOID:1837",
                    "label": "diabetic ketoacidosis",
                    "link_status": true,
                    "children": []
                },
                {
                    "id": "DOID:3650",
                    "label": "lactic acidosis",
                    "link_status": true,
                    "children": []
                }
            ]
        },
        {
            "id": "DOID:12700",
            "label": "hyperprolactinemia",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:1920",
            "label": "hyperuricemia",
            "link_status": true,
            "children": [
                {
                    "id": "DOID:0112127",
                    "label": "HRPT-related hyperuricemia",
                    "link_status": true,
                    "children": []
                }
            ]
        },
        {
            "id": "DOID:374",
            "label": "nutrition disease",
            "link_status": true,
            "children": [
                {
                    "id": "DOID:5113",
                    "label": "nutritional deficiency disease",
                    "link_status": true,
                    "children": [
                        {
                            "id": "DOID:0050083",
                            "label": "Keshan disease",
                            "link_status": true,
                            "children": []
                        },
                        {
                            "id": "DOID:0070313",
                            "label": "thiamine deficiency disease",
                            "link_status": false,
                            "children": [
                                {
                                    "id": "DOID:10915",
                                    "label": "Wernicke-Korsakoff syndrome",
                                    "link_status": true,
                                    "children": []
                                }
                            ]
                        },
                        {
                            "id": "DOID:11249",
                            "label": "vitamin K deficiency bleeding",
                            "link_status": true,
                            "children": []
                        },
                        {
                            "id": "DOID:11801",
                            "label": "protein-energy malnutrition",
                            "link_status": true,
                            "children": []
                        },
                        {
                            "id": "DOID:13381",
                            "label": "pernicious anemia",
                            "link_status": true,
                            "children": []
                        },
                        {
                            "id": "DOID:14026",
                            "label": "folic acid deficiency anemia",
                            "link_status": true,
                            "children": []
                        },
                        {
                            "id": "DOID:8454",
                            "label": "riboflavin deficiency",
                            "link_status": true,
                            "children": []
                        },
                        {
                            "id": "DOID:8455",
                            "label": "pyridoxine deficiency anemia",
                            "link_status": true,
                            "children": []
                        },
                        {
                            "id": "DOID:8456",
                            "label": "choline deficiency disease",
                            "link_status": true,
                            "children": []
                        },
                        {
                            "id": "DOID:8457",
                            "label": "pellagra",
                            "link_status": true,
                            "children": []
                        }
                    ]
                },
                {
                    "id": "DOID:654",
                    "label": "overnutrition",
                    "link_status": true,
                    "children": [
                        {
                            "id": "DOID:9970",
                            "label": "obesity",
                            "link_status": true,
                            "children": [
                                {
                                    "id": "DOID:11981",
                                    "label": "morbid obesity",
                                    "link_status": true,
                                    "children": []
                                }
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "id": "DOID:9969",
            "label": "carotenemia",
            "link_status": true,
            "children": []
        }
    ],
    "id_list": [
        "DOID:12119",
        "DOID:0050758",
        "DOID:0050336",
        "DOID:10915",
        "DOID:0061135",
        "DOID:11981",
        "DOID:0112127",
        "DOID:9969",
        "DOID:0070313",
        "DOID:13381",
        "DOID:8456",
        "DOID:9970",
        "DOID:10575",
        "DOID:374",
        "DOID:4500",
        "DOID:0080170",
        "DOID:8454",
        "DOID:11249",
        "DOID:0060702",
        "DOID:6652",
        "DOID:0060701",
        "DOID:12678",
        "DOID:0050083",
        "DOID:2485",
        "DOID:0111063",
        "DOID:0050711",
        "DOID:0050459",
        "DOID:12700",
        "DOID:8455",
        "DOID:0060700",
        "DOID:0061136",
        "DOID:1837",
        "DOID:0050032",
        "DOID:0060699",
        "DOID:0060158",
        "DOID:2351",
        "DOID:5113",
        "DOID:8457",
        "DOID:14026",
        "DOID:654",
        "DOID:182",
        "DOID:1920",
        "DOID:11801",
        "DOID:3650"
    ],
    "unlinked_id_list": [
        "DOID:10575",
        "DOID:0070313",
        "DOID:2485",
        "DOID:0050032"
    ],
    "crossref": [
        {
            "id": "DOID:0060158",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060158",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0AB32TQQ9-1",
            "uniprot_ac": "A0AB32TQQ9",
            "uniprot_id": "A0AB32TQQ9_DANRE",
            "refseq_ac": "NP_001002338",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "triacylglycerol lipase",
                    "type": "recommended"
                },
                {
                    "name": "3.1.1.3",
                    "type": "synonym"
                },
                {
                    "name": "patatin-like phospholipase domain containing 3 isoform 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "pnpla3",
                    "type": "recommended"
                },
                {
                    "name": "pnpla3",
                    "type": "synonym"
                },
                {
                    "name": "zgc:92195",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AB32TQQ9-1",
            "evidence": [
                {
                    "id": "0060158",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060158"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9PW80-1",
            "uniprot_ac": "Q9PW80",
            "uniprot_id": "IF2B3_DANRE",
            "refseq_ac": "NP_571566",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Insulin-like growth factor 2 mRNA-binding protein 3",
                    "type": "recommended"
                },
                {
                    "name": "Decapentaplegic and Vg-related 1 RNA-binding protein",
                    "type": "synonym"
                },
                {
                    "name": "IGF-II mRNA-binding protein 3",
                    "type": "synonym"
                },
                {
                    "name": "IGF2 mRNA-binding protein 3",
                    "type": "synonym"
                },
                {
                    "name": "IMP-3",
                    "type": "synonym"
                },
                {
                    "name": "IMP3",
                    "type": "synonym"
                },
                {
                    "name": "VICKZ family member 3",
                    "type": "synonym"
                },
                {
                    "name": "Vg1 RBP",
                    "type": "synonym"
                },
                {
                    "name": "Vg1 RNA-binding protein",
                    "type": "synonym"
                },
                {
                    "name": "Vg1-RBP",
                    "type": "synonym"
                },
                {
                    "name": "decapentaplegic and Vg-related 1 RNA-binding protein",
                    "type": "synonym"
                },
                {
                    "name": "insulin-like growth factor 2 mRNA-binding protein 3",
                    "type": "synonym"
                },
                {
                    "name": "vg1 RNA-binding protein",
                    "type": "synonym"
                },
                {
                    "name": "vg1-RBP",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "igf2bp3",
                    "type": "recommended"
                },
                {
                    "name": "dvr1rbp",
                    "type": "synonym"
                },
                {
                    "name": "igf2bp3",
                    "type": "synonym"
                },
                {
                    "name": "vickz3",
                    "type": "synonym"
                },
                {
                    "name": "wu:fb79c12",
                    "type": "synonym"
                },
                {
                    "name": "wu:fe06h09",
                    "type": "synonym"
                },
                {
                    "name": "zVg1RBP",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9PW80-1",
            "evidence": [
                {
                    "id": "0060158",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060158"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A0R4IVY2-1",
            "uniprot_ac": "A0A0R4IVY2",
            "uniprot_id": "A0A0R4IVY2_DANRE",
            "refseq_ac": "NP_001082843",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Uncharacterized protein LOC557028",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein LOC557028",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "igf2bp2b",
                    "type": "recommended"
                },
                {
                    "name": "igf2bp2b",
                    "type": "synonym"
                },
                {
                    "name": "si:dkey-24b15.4",
                    "type": "synonym"
                },
                {
                    "name": "wu:fb81e12",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A0R4IVY2-1",
            "evidence": [
                {
                    "id": "0060158",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060158"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q08CK7-1",
            "uniprot_ac": "Q08CK7",
            "uniprot_id": "IF2B1_DANRE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Insulin-like growth factor 2 mRNA-binding protein 1",
                    "type": "recommended"
                },
                {
                    "name": "IGF-II mRNA-binding protein 1",
                    "type": "synonym"
                },
                {
                    "name": "IGF2 mRNA-binding protein 1",
                    "type": "synonym"
                },
                {
                    "name": "IMP-1",
                    "type": "synonym"
                },
                {
                    "name": "VICKZ family member 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "igf2bp1",
                    "type": "recommended"
                },
                {
                    "name": "CRDBP",
                    "type": "synonym"
                },
                {
                    "name": "IMP1",
                    "type": "synonym"
                },
                {
                    "name": "fb96d05",
                    "type": "synonym"
                },
                {
                    "name": "vickz1",
                    "type": "synonym"
                },
                {
                    "name": "wu:fb18f03",
                    "type": "synonym"
                },
                {
                    "name": "wu:fb96d05",
                    "type": "synonym"
                },
                {
                    "name": "wu:fi72a06",
                    "type": "synonym"
                },
                {
                    "name": "zgc:152963",
                    "type": "synonym"
                }
            ],
            "record_id": "Q08CK7-1",
            "evidence": [
                {
                    "id": "0060158",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060158"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9WVK0-1",
            "uniprot_ac": "Q9WVK0",
            "uniprot_id": "ATRAP_MOUSE",
            "refseq_ac": "NP_033772",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Type-1 angiotensin II receptor-associated protein",
                    "type": "recommended"
                },
                {
                    "name": "AT1 receptor-associated protein",
                    "type": "synonym"
                },
                {
                    "name": "type-1 angiotensin II receptor-associated protein isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "type-1 angiotensin II receptor-associated protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Agtrap",
                    "type": "recommended"
                },
                {
                    "name": "3300002E14Rik",
                    "type": "synonym"
                },
                {
                    "name": "AT1R",
                    "type": "synonym"
                },
                {
                    "name": "Agtrap",
                    "type": "synonym"
                },
                {
                    "name": "Atrap",
                    "type": "synonym"
                },
                {
                    "name": "D4Wsu124e",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9WVK0-1",
            "evidence": [
                {
                    "id": "0060158",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060158"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q91WW7-1",
            "uniprot_ac": "Q91WW7",
            "uniprot_id": "PLPL3_MOUSE",
            "refseq_ac": "NP_473429",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "1-acylglycerol-3-phosphate O-acyltransferase Pnpla3",
                    "type": "recommended"
                },
                {
                    "name": "1-acylglycerol-3-phosphate O-acyltransferase Pnpla3 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "1-acylglycerol-3-phosphate O-acyltransferase Pnpla3",
                    "type": "synonym"
                },
                {
                    "name": "2.3.1.51",
                    "type": "synonym"
                },
                {
                    "name": "3.1.1.3",
                    "type": "synonym"
                },
                {
                    "name": "3.1.1.4",
                    "type": "synonym"
                },
                {
                    "name": "ADPN",
                    "type": "synonym"
                },
                {
                    "name": "Acylglycerol transacylase",
                    "type": "synonym"
                },
                {
                    "name": "Adiponutrin",
                    "type": "synonym"
                },
                {
                    "name": "Calcium-independent phospholipase A2-epsilon",
                    "type": "synonym"
                },
                {
                    "name": "Lysophosphatidic acid acyltransferase",
                    "type": "synonym"
                },
                {
                    "name": "Patatin-like phospholipase domain-containing protein 3",
                    "type": "synonym"
                },
                {
                    "name": "acylglycerol O-acyltransferase",
                    "type": "synonym"
                },
                {
                    "name": "acylglycerol transacylase",
                    "type": "synonym"
                },
                {
                    "name": "adiponutrin",
                    "type": "synonym"
                },
                {
                    "name": "calcium-independent phospholipase A2-epsilon",
                    "type": "synonym"
                },
                {
                    "name": "iPLA2-epsilon",
                    "type": "synonym"
                },
                {
                    "name": "lysophosphatidic acid acyltransferase",
                    "type": "synonym"
                },
                {
                    "name": "patatin-like phospholipase domain-containing protein 3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Pnpla3",
                    "type": "recommended"
                },
                {
                    "name": "Adpn",
                    "type": "synonym"
                },
                {
                    "name": "Pnpla3",
                    "type": "synonym"
                }
            ],
            "record_id": "Q91WW7-1",
            "evidence": [
                {
                    "id": "0060158",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060158"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q32LZ8-1",
            "uniprot_ac": "Q32LZ8",
            "uniprot_id": "PLPL5_MOUSE",
            "refseq_ac": "NP_083703",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Patatin-like phospholipase domain-containing protein 5",
                    "type": "recommended"
                },
                {
                    "name": "3.1.1.3",
                    "type": "synonym"
                },
                {
                    "name": "patatin-like phospholipase domain-containing protein 5",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Pnpla5",
                    "type": "recommended"
                },
                {
                    "name": "4833426H19Rik",
                    "type": "synonym"
                },
                {
                    "name": "GS2L",
                    "type": "synonym"
                },
                {
                    "name": "Pnpla5",
                    "type": "synonym"
                }
            ],
            "record_id": "Q32LZ8-1",
            "evidence": [
                {
                    "id": "0060158",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060158"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q3V1D5-1",
            "uniprot_ac": "Q3V1D5",
            "uniprot_id": "PLPL1_MOUSE",
            "refseq_ac": "NP_001030057",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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    "record_id": "doid.0060158"
}
