{
    "disease_id": "DOID:0050784",
    "recommended_name": {
        "id": "DOID:0050784",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050784",
        "name": "primary progressive multiple sclerosis",
        "description": "A multiple sclerosis that is characterized by steady worsening of neurologic functioning, without any distinct relapses or periods of remission. The rate of progression may vary over time, with occasional plateaus or temporary improvements, but the progression is continuous."
    },
    "synonyms": [
        {
            "id": "DOID:0050784",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050784",
            "name": "PPMS",
            "description": ""
        },
        {
            "id": "DOID:0050784",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050784",
            "name": "Primary-progressive MS",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0050784"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050784",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050784",
            "categories": []
        }
    ],
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                }
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                    "type": "synonym"
                },
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                    "name": "uncharacterized protein LOC368846 precursor",
                    "type": "synonym"
                }
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                {
                    "name": "mhc2d8.45b1",
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                    "name": "mhc2d8.45b1",
                    "type": "synonym"
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                    "name": "si:busm1-228j01.6",
                    "type": "synonym"
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                    "name": "si:dz228j01.6",
                    "type": "synonym"
                }
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                    "name": "il-4alpha",
                    "type": "synonym"
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                    "name": "interleukin-4 receptor subunit alpha isoform 2 precursor",
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                    "name": "soluble IL-4 receptor alpha",
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                    "id": "0050784",
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                    "name": "grn",
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                    "name": "sb:eu337",
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                    "name": "wu:fb11g12",
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                    "name": "Group-specific component",
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                    "name": "zgc:92753",
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                    "name": "Epithelin/granulin precursor",
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                    "name": "Glycoprotein of 88 Kda",
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                {
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                    "name": "proepithelin",
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                {
                    "name": "progranulin precursor",
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                {
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                {
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                {
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                {
                    "name": "92 kDa type IV collagenase",
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                {
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                    "name": "GELB",
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                    "name": "Gelatinase B",
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                    "name": "Azoreductase",
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                    "name": "DT-diaphorase",
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                },
                {
                    "name": "NAD(P)H dehydrogenase [quinone] 1 isoform a",
                    "type": "synonym"
                },
                {
                    "name": "NAD(P)H dehydrogenase, quinone 1",
                    "type": "synonym"
                },
                {
                    "name": "NAD(P)H-quinone oxidoreductase",
                    "type": "synonym"
                },
                {
                    "name": "NAD(P)H:Quinone acceptor oxidoreductase type 1",
                    "type": "synonym"
                },
                {
                    "name": "NAD(P)H:menadione oxidoreductase 1",
                    "type": "synonym"
                },
                {
                    "name": "NAD(P)H:quinone oxidoreductase 1",
                    "type": "synonym"
                },
                {
                    "name": "NAD(P)H:quinone oxireductase",
                    "type": "synonym"
                },
                {
                    "name": "Phylloquinone reductase",
                    "type": "synonym"
                },
                {
                    "name": "QR1",
                    "type": "synonym"
                },
                {
                    "name": "Quinone reductase 1",
                    "type": "synonym"
                },
                {
                    "name": "azoreductase",
                    "type": "synonym"
                },
                {
                    "name": "diaphorase (NADH/NADPH) (cytochrome b-5 reductase)",
                    "type": "synonym"
                },
                {
                    "name": "diaphorase-4",
                    "type": "synonym"
                },
                {
                    "name": "dioxin-inducible 1",
                    "type": "synonym"
                },
                {
                    "name": "menadione reductase",
                    "type": "synonym"
                },
                {
                    "name": "phylloquinone reductase",
                    "type": "synonym"
                },
                {
                    "name": "quinone reductase 1",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "NQO1",
                    "type": "recommended"
                },
                {
                    "name": "DHQU",
                    "type": "synonym"
                },
                {
                    "name": "DIA4",
                    "type": "synonym"
                },
                {
                    "name": "DTD",
                    "type": "synonym"
                },
                {
                    "name": "NMOR1",
                    "type": "synonym"
                },
                {
                    "name": "NMORI",
                    "type": "synonym"
                },
                {
                    "name": "NQO1",
                    "type": "synonym"
                },
                {
                    "name": "QR1",
                    "type": "synonym"
                }
            ],
            "record_id": "P15559-1",
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                {
                    "id": "0050784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050784"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O60258-1",
            "uniprot_ac": "O60258",
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Fibroblast growth factor 17",
                    "type": "recommended"
                },
                {
                    "name": "FGF-17",
                    "type": "synonym"
                },
                {
                    "name": "fibroblast growth factor 17 isoform 2 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "FGF17",
                    "type": "recommended"
                },
                {
                    "name": "FGF-13",
                    "type": "synonym"
                },
                {
                    "name": "FGF-17",
                    "type": "synonym"
                },
                {
                    "name": "FGF17",
                    "type": "synonym"
                },
                {
                    "name": "HH20",
                    "type": "synonym"
                },
                {
                    "name": "PRO187",
                    "type": "synonym"
                }
            ],
            "record_id": "O60258-1",
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                {
                    "id": "0050784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050784"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q15465-1",
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
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                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Sonic hedgehog protein",
                    "type": "recommended"
                },
                {
                    "name": "3.1.-.-",
                    "type": "synonym"
                },
                {
                    "name": "HHG-1",
                    "type": "synonym"
                },
                {
                    "name": "SHH signaling molecule",
                    "type": "synonym"
                },
                {
                    "name": "SHH",
                    "type": "synonym"
                },
                {
                    "name": "Shh N-terminal processed signaling domains",
                    "type": "synonym"
                },
                {
                    "name": "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains",
                    "type": "synonym"
                },
                {
                    "name": "ShhNC",
                    "type": "synonym"
                },
                {
                    "name": "ShhNp",
                    "type": "synonym"
                },
                {
                    "name": "shh unprocessed N-terminal signaling and C-terminal autoprocessing domains",
                    "type": "synonym"
                },
                {
                    "name": "sonic hedgehog homolog",
                    "type": "synonym"
                },
                {
                    "name": "sonic hedgehog protein isoform 1 preproprotein",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "SHH",
                    "type": "recommended"
                },
                {
                    "name": "HHG1",
                    "type": "synonym"
                },
                {
                    "name": "HLP3",
                    "type": "synonym"
                },
                {
                    "name": "HPE3",
                    "type": "synonym"
                },
                {
                    "name": "MCOPCB5",
                    "type": "synonym"
                },
                {
                    "name": "SHH",
                    "type": "synonym"
                },
                {
                    "name": "SMMCI",
                    "type": "synonym"
                },
                {
                    "name": "ShhNC",
                    "type": "synonym"
                },
                {
                    "name": "TPTPS",
                    "type": "synonym"
                },
                {
                    "name": "TPT",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050784",
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                }
            ]
        },
        {
            "uniprot_canonical_ac": "P14780-1",
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                {
                    "name": "Homo sapiens",
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "Matrix metalloproteinase-9",
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                },
                {
                    "name": "3.4.24.35",
                    "type": "synonym"
                },
                {
                    "name": "92 kDa gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "92 kDa type IV collagenase",
                    "type": "synonym"
                },
                {
                    "name": "GELB",
                    "type": "synonym"
                },
                {
                    "name": "Gelatinase B",
                    "type": "synonym"
                },
                {
                    "name": "MMP-9",
                    "type": "synonym"
                },
                {
                    "name": "macrophage gelatinase",
                    "type": "synonym"
                },
                {
                    "name": "matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)",
                    "type": "synonym"
                },
                {
                    "name": "matrix metalloproteinase-9 preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "type V collagenase",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "MMP9",
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                {
                    "name": "CLG4B",
                    "type": "synonym"
                },
                {
                    "name": "GELB",
                    "type": "synonym"
                },
                {
                    "name": "MANDP2",
                    "type": "synonym"
                },
                {
                    "name": "MMP-9",
                    "type": "synonym"
                },
                {
                    "name": "MMP9",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050784"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P28799-1",
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                    "name": "Homo sapiens",
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                    "name": "Progranulin",
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                    "name": "Acrogranin",
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                {
                    "name": "Epithelin precursor",
                    "type": "synonym"
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                {
                    "name": "Epithelin-1",
                    "type": "synonym"
                },
                {
                    "name": "Epithelin-2",
                    "type": "synonym"
                },
                {
                    "name": "GP88",
                    "type": "synonym"
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                {
                    "name": "Glycoprotein 88",
                    "type": "synonym"
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                {
                    "name": "Glycoprotein of 88 Kda",
                    "type": "synonym"
                },
                {
                    "name": "Granulin A",
                    "type": "synonym"
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                {
                    "name": "Granulin B",
                    "type": "synonym"
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                {
                    "name": "Granulin C",
                    "type": "synonym"
                },
                {
                    "name": "Granulin D",
                    "type": "synonym"
                },
                {
                    "name": "Granulin E",
                    "type": "synonym"
                },
                {
                    "name": "Granulin F",
                    "type": "synonym"
                },
                {
                    "name": "Granulin G",
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                },
                {
                    "name": "Granulin precursor",
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                },
                {
                    "name": "PC cell-derived growth factor",
                    "type": "synonym"
                },
                {
                    "name": "PCDGF",
                    "type": "synonym"
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                {
                    "name": "PEPI",
                    "type": "synonym"
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                {
                    "name": "PGRN",
                    "type": "synonym"
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                {
                    "name": "Proepithelin",
                    "type": "synonym"
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                {
                    "name": "acrogranin",
                    "type": "synonym"
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                {
                    "name": "glycoprotein 88",
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                },
                {
                    "name": "glycoprotein of 88 Kda",
                    "type": "synonym"
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                {
                    "name": "granulin-epithelin",
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                {
                    "name": "granulins",
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                {
                    "name": "proepithelin",
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                {
                    "name": "progranulin precursor",
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                {
                    "name": "progranulin",
                    "type": "synonym"
                }
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                    "name": "GRN",
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                    "name": "CLN11",
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                    "name": "FTD2",
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                    "name": "GEP",
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                    "name": "GP88",
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                    "name": "GRN",
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                    "name": "PCDGF",
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                    "name": "PEPI",
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                {
                    "name": "PGRN",
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            ],
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                    "id": "0050784",
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            ]
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                    "name": "Homo sapiens",
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                {
                    "name": "Insulin-like growth factor-binding protein 3",
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                    "name": "IBP-3",
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                {
                    "name": "IGF-binding protein 3",
                    "type": "synonym"
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                {
                    "name": "IGFBP-3",
                    "type": "synonym"
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                {
                    "name": "acid stable subunit of the 140 K IGF complex",
                    "type": "synonym"
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                {
                    "name": "binding protein 29",
                    "type": "synonym"
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                {
                    "name": "binding protein 53",
                    "type": "synonym"
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                {
                    "name": "growth hormone-dependent binding protein",
                    "type": "synonym"
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                {
                    "name": "insulin-like growth factor-binding protein 3 isoform b precursor",
                    "type": "synonym"
                }
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                    "name": "IGFBP3",
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                {
                    "name": "BP-53",
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                    "name": "IBP-3",
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                {
                    "name": "IBP3",
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                {
                    "name": "IGFBP-3",
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                },
                {
                    "name": "IGFBP3",
                    "type": "synonym"
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                    "id": "0050784",
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                    "name": "Homo sapiens",
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            ],
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                    "name": "Vitamin D-binding protein",
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                    "name": "DBP-maf",
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                {
                    "name": "DBP",
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                {
                    "name": "Gc protein-derived macrophage activating factor",
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                    "name": "Gc-MAF",
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                {
                    "name": "Gc-globulin",
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                {
                    "name": "GcMAF",
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                {
                    "name": "Gc",
                    "type": "synonym"
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                {
                    "name": "Group-specific component",
                    "type": "synonym"
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                {
                    "name": "VDB",
                    "type": "synonym"
                },
                {
                    "name": "Vitamin D-binding protein-macrophage activating factor",
                    "type": "synonym"
                },
                {
                    "name": "epididymis secretory protein Li 51",
                    "type": "synonym"
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                {
                    "name": "gc protein-derived macrophage activating factor",
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                },
                {
                    "name": "gc-globulin",
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                {
                    "name": "group-specific component (vitamin D binding protein)",
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                {
                    "name": "vitamin D-binding alpha-globulin",
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                {
                    "name": "vitamin D-binding protein isoform 1 precursor",
                    "type": "synonym"
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                {
                    "name": "vitamin D-binding protein-macrophage activating factor",
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                },
                {
                    "name": "vitamin D-binding protein",
                    "type": "synonym"
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                    "name": "GC",
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                    "name": "DBP-maf",
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                {
                    "name": "DBP/GC",
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                {
                    "name": "DBP",
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                {
                    "name": "GC",
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                {
                    "name": "GRD3",
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                {
                    "name": "Gc-MAF",
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                {
                    "name": "GcMAF",
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                {
                    "name": "HEL-S-51",
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                    "name": "VDBG",
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                {
                    "name": "VDBP",
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                {
                    "name": "VDB",
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                    "id": "0050784",
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                    "name": "Cholinesterase",
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                    "name": "3.1.1.8",
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                {
                    "name": "Acylcholine acylhydrolase",
                    "type": "synonym"
                },
                {
                    "name": "Butyrylcholine esterase",
                    "type": "synonym"
                },
                {
                    "name": "Choline esterase II",
                    "type": "synonym"
                },
                {
                    "name": "Pseudocholinesterase",
                    "type": "synonym"
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                {
                    "name": "acylcholine acylhydrolase",
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                {
                    "name": "butyrylcholine esterase",
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                {
                    "name": "choline esterase II",
                    "type": "synonym"
                },
                {
                    "name": "cholinesterase (serum) 2",
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                },
                {
                    "name": "cholinesterase 1",
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                },
                {
                    "name": "cholinesterase precursor",
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                {
                    "name": "pseudocholinesterase",
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                    "name": "BCHED",
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                {
                    "name": "BCHE",
                    "type": "synonym"
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                {
                    "name": "CHE1",
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                {
                    "name": "CHE2",
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                {
                    "name": "E1",
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                    "id": "0050784",
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            ]
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            ],
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                    "name": "Interleukin-4 receptor subunit alpha",
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                    "name": "IL-4 receptor subunit alpha",
                    "type": "synonym"
                },
                {
                    "name": "IL-4-binding protein",
                    "type": "synonym"
                },
                {
                    "name": "IL-4R subunit alpha",
                    "type": "synonym"
                },
                {
                    "name": "IL-4R-alpha",
                    "type": "synonym"
                },
                {
                    "name": "IL-4RA",
                    "type": "synonym"
                },
                {
                    "name": "IL4-BP",
                    "type": "synonym"
                },
                {
                    "name": "interleukin 13 receptor",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-4 receptor alpha chain",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-4 receptor subunit alpha isoform a precursor",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-4 receptor subunit alpha",
                    "type": "synonym"
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                {
                    "name": "IL4R",
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                {
                    "name": "582J2.1",
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                },
                {
                    "name": "CD124",
                    "type": "synonym"
                },
                {
                    "name": "IL-4RA",
                    "type": "synonym"
                },
                {
                    "name": "IL4RA",
                    "type": "synonym"
                },
                {
                    "name": "IL4R",
                    "type": "synonym"
                }
            ],
            "record_id": "P24394-1",
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                {
                    "id": "0050784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050784"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P01911-1",
            "uniprot_ac": "P01911",
            "uniprot_id": "DRB1_HUMAN",
            "refseq_ac": "NP_001230894",
            "glycoprotein": "yes",
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                {
                    "name": "Homo sapiens",
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                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "HLA class II histocompatibility antigen, DRB1 beta chain",
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                },
                {
                    "name": "HLA class II histocompatibility antigen, DR-1 beta chain",
                    "type": "synonym"
                },
                {
                    "name": "HLA-DRB1",
                    "type": "synonym"
                },
                {
                    "name": "Human leukocyte antigen DRB1",
                    "type": "synonym"
                },
                {
                    "name": "MHC class II HLA-DR beta 1 chain",
                    "type": "synonym"
                },
                {
                    "name": "human leucocyte antigen DRB1",
                    "type": "synonym"
                },
                {
                    "name": "lymphocyte antigen DRB1",
                    "type": "synonym"
                },
                {
                    "name": "major histocompatibility complex, class II, DR beta 1 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "HLA-DRB1",
                    "type": "recommended"
                },
                {
                    "name": "DRB1",
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                },
                {
                    "name": "HLA-DR1B",
                    "type": "synonym"
                },
                {
                    "name": "HLA-DRB1",
                    "type": "synonym"
                },
                {
                    "name": "HLA-DRB",
                    "type": "synonym"
                },
                {
                    "name": "SS1",
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                }
            ],
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                {
                    "id": "0050784",
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                }
            ]
        },
        {
            "uniprot_canonical_ac": "P01920-1",
            "uniprot_ac": "P01920",
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                {
                    "name": "Homo sapiens",
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                }
            ],
            "protein_names": [
                {
                    "name": "HLA class II histocompatibility antigen, DQ beta 1 chain",
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                {
                    "name": "HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor",
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                {
                    "name": "HLA class II histocompatibility antigen, DQ beta 1 chain",
                    "type": "synonym"
                },
                {
                    "name": "MHC class II DQ beta chain",
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                },
                {
                    "name": "MHC class II HLA-DQ beta glycoprotein",
                    "type": "synonym"
                },
                {
                    "name": "MHC class II antigen DQB1",
                    "type": "synonym"
                },
                {
                    "name": "MHC class II antigen HLA-DQ-beta-1",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "HLA-DQB1",
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                },
                {
                    "name": "CELIAC1",
                    "type": "synonym"
                },
                {
                    "name": "HLA-DQB1",
                    "type": "synonym"
                },
                {
                    "name": "HLA-DQB",
                    "type": "synonym"
                },
                {
                    "name": "IDDM1",
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                }
            ],
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                {
                    "id": "0050784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050784"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8WXS8-1",
            "uniprot_ac": "Q8WXS8",
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                    "name": "Homo sapiens",
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "A disintegrin and metalloproteinase with thrombospondin motifs 14",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.-",
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                },
                {
                    "name": "A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform 2 preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "ADAM-TS 14",
                    "type": "synonym"
                },
                {
                    "name": "ADAM-TS14",
                    "type": "synonym"
                },
                {
                    "name": "ADAMTS-14",
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                },
                {
                    "name": "a disintegrin and metalloproteinase with thrombospondin motifs 14",
                    "type": "synonym"
                },
                {
                    "name": "a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ADAMTS14",
                    "type": "recommended"
                },
                {
                    "name": "ADAMTS14",
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                }
            ],
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                {
                    "id": "0050784",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050784"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050784"
}