{
    "disease_id": "DOID:0050456",
    "recommended_name": {
        "id": "DOID:0050456",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050456",
        "name": "Buruli ulcer disease",
        "description": "A primary bacterial infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Mycobacterium ulcerans, which could be transmitted_by insects. The bacterium produces a toxin, named mycolactone, which causes subcutaneous fat necrosis and inhibits an immune response. The infection has_symptom nodule, which is a painless, mobile swelling in the skin."
    },
    "synonyms": [
        {
            "id": "DOID:0050456",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050456",
            "name": "Bairnsdale ulcer",
            "description": ""
        },
        {
            "id": "DOID:0050456",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050456",
            "name": "Daintree ulcer",
            "description": ""
        },
        {
            "id": "DOID:0050456",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050456",
            "name": "Mossman ulcer",
            "description": ""
        },
        {
            "id": "DOID:0050456",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050456",
            "name": "Searl ulcer",
            "description": ""
        },
        {
            "id": "DOID:0050456",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050456",
            "name": "Searle's ulcer",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0050456"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050456",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050456",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "P41251-1",
            "uniprot_ac": "P41251",
            "uniprot_id": "NRAM1_MOUSE",
            "refseq_ac": "NP_038640",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Natural resistance-associated macrophage protein 1",
                    "type": "recommended"
                },
                {
                    "name": "NRAMP 1",
                    "type": "synonym"
                },
                {
                    "name": "Solute carrier family 11 member 1",
                    "type": "synonym"
                },
                {
                    "name": "host resistance locus Bcg/Ity/Lsh",
                    "type": "synonym"
                },
                {
                    "name": "natural resistance-associated macrophage protein 1 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "natural resistance-associated macrophage protein 1",
                    "type": "synonym"
                },
                {
                    "name": "solute carrier family 11 member 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Slc11a1",
                    "type": "recommended"
                },
                {
                    "name": "Bcg",
                    "type": "synonym"
                },
                {
                    "name": "Ity1",
                    "type": "synonym"
                },
                {
                    "name": "Ity",
                    "type": "synonym"
                },
                {
                    "name": "Lsh",
                    "type": "synonym"
                },
                {
                    "name": "Nramp1",
                    "type": "synonym"
                },
                {
                    "name": "Nramp",
                    "type": "synonym"
                },
                {
                    "name": "Slc11a1",
                    "type": "synonym"
                },
                {
                    "name": "ity",
                    "type": "synonym"
                }
            ],
            "record_id": "P41251-1",
            "evidence": [
                {
                    "id": "0050456",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050456"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q12078-1",
            "uniprot_ac": "Q12078",
            "uniprot_id": "SMF3_YEAST",
            "refseq_ac": "NP_013134",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Iron transporter SMF3",
                    "type": "recommended"
                },
                {
                    "name": "putative divalent metal ion transporter SMF3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "SMF3",
                    "type": "recommended"
                },
                {
                    "name": "SMF3",
                    "type": "synonym"
                }
            ],
            "record_id": "Q12078-1",
            "evidence": [
                {
                    "id": "0050456",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050456"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P38925-1",
            "uniprot_ac": "P38925",
            "uniprot_id": "SMF1_YEAST",
            "refseq_ac": "NP_014519",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Manganese transporter SMF1",
                    "type": "recommended"
                },
                {
                    "name": "divalent metal ion transporter SMF1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "SMF1",
                    "type": "recommended"
                },
                {
                    "name": "ESP1",
                    "type": "synonym"
                },
                {
                    "name": "SBS1",
                    "type": "synonym"
                },
                {
                    "name": "SMF1",
                    "type": "synonym"
                }
            ],
            "record_id": "P38925-1",
            "evidence": [
                {
                    "id": "0050456",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050456"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P38778-1",
            "uniprot_ac": "P38778",
            "uniprot_id": "SMF2_YEAST",
            "refseq_ac": "NP_011917",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Manganese transporter SMF2",
                    "type": "recommended"
                },
                {
                    "name": "divalent metal ion transporter SMF2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "SMF2",
                    "type": "recommended"
                },
                {
                    "name": "SMF2",
                    "type": "synonym"
                }
            ],
            "record_id": "P38778-1",
            "evidence": [
                {
                    "id": "0050456",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050456"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P70553-1",
            "uniprot_ac": "P70553",
            "uniprot_id": "NRAM1_RAT",
            "refseq_ac": "NP_001026828",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Natural resistance-associated macrophage protein 1",
                    "type": "recommended"
                },
                {
                    "name": "NRAMP 1",
                    "type": "synonym"
                },
                {
                    "name": "Solute carrier family 11 member 1",
                    "type": "synonym"
                },
                {
                    "name": "natural resistance-associated macrophage protein 1 isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "natural resistance-associated macrophage protein 1",
                    "type": "synonym"
                },
                {
                    "name": "solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1",
                    "type": "synonym"
                },
                {
                    "name": "solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Slc11a1",
                    "type": "recommended"
                },
                {
                    "name": "Bcg",
                    "type": "synonym"
                },
                {
                    "name": "Itg",
                    "type": "synonym"
                },
                {
                    "name": "Lsh",
                    "type": "synonym"
                },
                {
                    "name": "Nramp1",
                    "type": "synonym"
                },
                {
                    "name": "Slc11a1",
                    "type": "synonym"
                }
            ],
            "record_id": "P70553-1",
            "evidence": [
                {
                    "id": "0050456",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050456"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P49283-2",
            "uniprot_ac": "P49283",
            "uniprot_id": "MVL_DROME",
            "refseq_ac": "NP_001163668",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Protein Malvolio",
                    "type": "recommended"
                },
                {
                    "name": "/Divalent metal transporter",
                    "type": "synonym"
                },
                {
                    "name": "CG3671-PD",
                    "type": "synonym"
                },
                {
                    "name": "Mvl-PD",
                    "type": "synonym"
                },
                {
                    "name": "malvolio, isoform D",
                    "type": "synonym"
                },
                {
                    "name": "malvolio",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Mvl",
                    "type": "recommended"
                },
                {
                    "name": "CG3671",
                    "type": "synonym"
                },
                {
                    "name": "DMT1",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG3671",
                    "type": "synonym"
                },
                {
                    "name": "Mvl",
                    "type": "synonym"
                },
                {
                    "name": "NRM2",
                    "type": "synonym"
                },
                {
                    "name": "dNRAMP",
                    "type": "synonym"
                },
                {
                    "name": "mvl",
                    "type": "synonym"
                }
            ],
            "record_id": "P49283-2",
            "evidence": [
                {
                    "id": "0050456",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050456"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P49279-1",
            "uniprot_ac": "P49279",
            "uniprot_id": "NRAM1_HUMAN",
            "refseq_ac": "NP_000569",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Natural resistance-associated macrophage protein 1",
                    "type": "recommended"
                },
                {
                    "name": "Leishmaniasis resistance",
                    "type": "synonym"
                },
                {
                    "name": "NRAMP 1",
                    "type": "synonym"
                },
                {
                    "name": "Solute carrier family 11 member 1",
                    "type": "synonym"
                },
                {
                    "name": "natural resistance-associated macrophage protein 1",
                    "type": "synonym"
                },
                {
                    "name": "solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1",
                    "type": "synonym"
                },
                {
                    "name": "solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1",
                    "type": "synonym"
                },
                {
                    "name": "solute carrier family 11 (sodium/phosphate symporters), member 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "SLC11A1",
                    "type": "recommended"
                },
                {
                    "name": "LSH",
                    "type": "synonym"
                },
                {
                    "name": "NRAMP1",
                    "type": "synonym"
                },
                {
                    "name": "NRAMP",
                    "type": "synonym"
                },
                {
                    "name": "SLC11A1",
                    "type": "synonym"
                }
            ],
            "record_id": "P49279-1",
            "evidence": [
                {
                    "id": "0050456",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050456"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050456"
}