{
    "biomarker_id": "BD0261-1",
    "biomarker_canonical_id": "BD0261",
    "condition": {
        "recommended_name": {
            "id": "DOID:0080600",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080600",
            "name": "COVID-19",
            "description": "A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a subtype of Betacoronavirus pandemicum."
        },
        "synonyms": [
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019 Novel Coronavirus (2019-nCoV)",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "COVID19",
                "description": ""
            },
            {
                "id": "DOID:0080600",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080600",
                "name": "SARS-CoV-2 infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "COVID-19",
                "description": "A disease caused by infection with severe acute respiratory syndrome coronavirus 2."
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019-nCoV infection",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "coronavirus disease 2019",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2 infectious disease",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019 novel coronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "2019-nCoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-CoV-2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "SARS-coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "beta-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "betacoronavirus",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "severe acute respiratory syndrome coronavirus 2",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoV",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-CoVs",
                "description": ""
            },
            {
                "id": "MONDO:0100096",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0100096",
                "name": "-coronavirus",
                "description": ""
            }
        ],
        "id": "DOID:0080600"
    },
    "biomarker_component": [
        {
            "biomarker": "increased NT-proBNP level",
            "assessed_biomarker_entity_id": "P01160-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Natriuretic peptides A",
                "synonyms": [
                    {
                        "synonym": "Cardiodilatin"
                    },
                    {
                        "synonym": "CDD"
                    },
                    {
                        "synonym": "CDD-ANF"
                    },
                    {
                        "synonym": "Pro atrial natriuretic factor 1-30"
                    },
                    {
                        "synonym": "proANF 1-30"
                    },
                    {
                        "synonym": "Atrial natriuretic factor"
                    },
                    {
                        "synonym": "ANF"
                    },
                    {
                        "synonym": "Atrial natriuretic factor 1-33"
                    },
                    {
                        "synonym": "ANF 1-33"
                    },
                    {
                        "synonym": "Pro atrial natriuretic peptide 95-126"
                    },
                    {
                        "synonym": "proANP 95-126"
                    },
                    {
                        "synonym": "Pro atrial natriuretic factor 99-126"
                    },
                    {
                        "synonym": "proANF 99-126"
                    },
                    {
                        "synonym": "Pro atrial natriuretic peptide 79-98"
                    },
                    {
                        "synonym": "proANP 79-98"
                    },
                    {
                        "synonym": "Pro atrial natriuretic peptide 1-30"
                    },
                    {
                        "synonym": "proANP 1-30"
                    },
                    {
                        "synonym": "Long-acting natriuretic hormone"
                    },
                    {
                        "synonym": "LANH"
                    },
                    {
                        "synonym": "Atrial natriuretic factor 3-33"
                    },
                    {
                        "synonym": "ANF 3-33"
                    },
                    {
                        "synonym": "Pro atrial natriuretic factor 79-98"
                    },
                    {
                        "synonym": "proANF 79-98"
                    },
                    {
                        "synonym": "Pro atrial natriuretic peptide 31-67"
                    },
                    {
                        "synonym": "proANP 31-67"
                    },
                    {
                        "synonym": "Atrial natriuretic factor 8-33"
                    },
                    {
                        "synonym": "ANF 8-33"
                    },
                    {
                        "synonym": "Pro atrial natriuretic factor 31-67"
                    },
                    {
                        "synonym": "proANF 31-67"
                    },
                    {
                        "synonym": "CDD 95-126"
                    },
                    {
                        "synonym": "Cardionatrin"
                    },
                    {
                        "synonym": "Atriopeptin III"
                    },
                    {
                        "synonym": "CDD-ANP (99-126)"
                    },
                    {
                        "synonym": "Alpha-atrial natriuretic peptide"
                    },
                    {
                        "synonym": "Atriopeptin I"
                    },
                    {
                        "synonym": "CDD-ANP (95-126)"
                    },
                    {
                        "synonym": "Atriopeptin II"
                    },
                    {
                        "synonym": "Alpha-hANP"
                    },
                    {
                        "synonym": "Atrial natriuretic peptide prohormone"
                    },
                    {
                        "synonym": "preproANP"
                    },
                    {
                        "synonym": "proANP"
                    },
                    {
                        "synonym": "Atrial natriuretic factor prohormone"
                    },
                    {
                        "synonym": "proANF"
                    },
                    {
                        "synonym": "preproCDD-ANF"
                    },
                    {
                        "synonym": "Atriopeptigen"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "20569-0"
                }
            ],
            "evidence_source": [
                {
                    "id": "BD0261-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BD0261-1"
                },
                {
                    "id": "32305557",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32305557",
                    "tags": [
                        "assessed_biomarker_entity",
                        " assessed_biomarker_entity_id",
                        " biomarker"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "More severe COVID-19 infection is associated with higher mean troponin (SMD 0.53, 95% CI 0.30 to 0.75, p < 0.001), with a similar trend for creatine kinase-MB, myoglobin, and NT-proBNP. hsTnI and NT-proBNP levels increased during the course of hospitalization only in non-survivors."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "monitoring"
        }
    ],
    "evidence_source": [
        {
            "id": "BD0261-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BD0261-1"
        },
        {
            "id": "32305557",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/32305557",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "More severe COVID-19 infection is associated with higher mean troponin (SMD 0.53, 95% CI 0.30 to 0.75, p < 0.001), with a similar trend for creatine kinase-MB, myoglobin, and NT-proBNP. hsTnI and NT-proBNP levels increased during the course of hospitalization only in non-survivors."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BD0261-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BD0261-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "The impact of 2019 novel coronavirus on heart injury: A Systematic review and Meta-analysis.",
            "journal": "Progress in cardiovascular diseases",
            "authors": "Li JW, Han TW, Woodward M, Anderson CS, Zhou H, Chen YD, Neal B",
            "date": "2020",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32305557",
                    "url": "https://glygen.org/publication/PubMed/32305557"
                }
            ],
            "evidence": [
                {
                    "id": "AN6373-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BD0261-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}