{
    "biomarker_id": "BB3881-1",
    "biomarker_canonical_id": "BB3881",
    "condition": {
        "recommended_name": {
            "id": "DOID:9074",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:9074",
            "name": "systemic lupus erythematosus",
            "description": "A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart."
        },
        "synonyms": [
            {
                "id": "DOID:9074",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:9074",
                "name": "Lupus Erythematosus, systemic",
                "description": ""
            },
            {
                "id": "DOID:9074",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:9074",
                "name": "SLE - Lupus Erythematosus, systemic",
                "description": ""
            },
            {
                "id": "DOID:9074",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:9074",
                "name": "disseminated lupus erythematosus",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "systemic lupus erythematosus",
                "description": "An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific."
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "Lupus",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "SLE",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "SLE - lupus erythematosus, systemic",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "disseminated lupus erythematosus",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "lupus erythematosus, systemic",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "systemic lupus erythematosus",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "systemic lupus erythematosus (disease)",
                "description": ""
            },
            {
                "id": "MONDO:0007915",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0007915",
                "name": "systemic lupus erythematosus susceptibility to",
                "description": ""
            },
            {
                "id": "MONDO:0010433",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010433",
                "name": "systemic lupus erythematosus, susceptibility to, 15",
                "description": ""
            },
            {
                "id": "MONDO:0010433",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010433",
                "name": "SLEB15",
                "description": ""
            },
            {
                "id": "MONDO:0010433",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0010433",
                "name": "systemic lupus erythematosus, susceptibility to, 15",
                "description": ""
            },
            {
                "id": "MONDO:0011560",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011560",
                "name": "systemic lupus erythematosus, susceptibility to, 3",
                "description": ""
            },
            {
                "id": "MONDO:0011560",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011560",
                "name": "SLEB3",
                "description": ""
            },
            {
                "id": "MONDO:0011560",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011560",
                "name": "systemic lupus erythematosus, susceptibility to, 3",
                "description": ""
            },
            {
                "id": "MONDO:0012036",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012036",
                "name": "systemic lupus erythematosus, susceptibility to, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012036",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012036",
                "name": "SLEB4",
                "description": ""
            },
            {
                "id": "MONDO:0012036",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012036",
                "name": "systemic lupus erythematosus, susceptibility to, 4",
                "description": ""
            },
            {
                "id": "MONDO:0012361",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012361",
                "name": "systemic lupus erythematosus, susceptibility to, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012361",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012361",
                "name": "SLEB5",
                "description": ""
            },
            {
                "id": "MONDO:0012361",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012361",
                "name": "systemic lupus erythematosus, susceptibility to, 5",
                "description": ""
            },
            {
                "id": "MONDO:0012369",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012369",
                "name": "systemic lupus erythematosus, susceptibility to, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012369",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012369",
                "name": "SLEB6",
                "description": ""
            },
            {
                "id": "MONDO:0012369",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012369",
                "name": "systemic lupus erythematosus, susceptibility to, 6",
                "description": ""
            },
            {
                "id": "MONDO:0012403",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012403",
                "name": "systemic lupus erythematosus, susceptibility to, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012403",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012403",
                "name": "SLEB7",
                "description": ""
            },
            {
                "id": "MONDO:0012403",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012403",
                "name": "systemic lupus erythematosus, susceptibility to, 7",
                "description": ""
            },
            {
                "id": "MONDO:0012404",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012404",
                "name": "systemic lupus erythematosus, susceptibility to, 8",
                "description": ""
            },
            {
                "id": "MONDO:0012404",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012404",
                "name": "SLEB8",
                "description": ""
            },
            {
                "id": "MONDO:0012404",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012404",
                "name": "systemic lupus erythematosus, susceptibility to, 8",
                "description": ""
            },
            {
                "id": "MONDO:0012836",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012836",
                "name": "systemic lupus erythematosus, susceptibility to, 12",
                "description": ""
            },
            {
                "id": "MONDO:0012836",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012836",
                "name": "SLEB12",
                "description": ""
            },
            {
                "id": "MONDO:0012836",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012836",
                "name": "systemic lupus erythematosus, susceptibility to, 12",
                "description": ""
            },
            {
                "id": "MONDO:0012884",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012884",
                "name": "systemic lupus erythematosus, susceptibility to, 13",
                "description": ""
            },
            {
                "id": "MONDO:0012884",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012884",
                "name": "SLEB13",
                "description": ""
            },
            {
                "id": "MONDO:0012884",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012884",
                "name": "systemic lupus erythematosus, susceptibility to, 13",
                "description": ""
            },
            {
                "id": "MONDO:0013152",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013152",
                "name": "systemic lupus erythematosus, susceptibility to, 14",
                "description": ""
            },
            {
                "id": "MONDO:0013152",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013152",
                "name": "SLEB14",
                "description": ""
            },
            {
                "id": "MONDO:0013152",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013152",
                "name": "systemic lupus erythematosus, susceptibility to, 14",
                "description": ""
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "autosomal systemic lupus erythematosus type 16",
                "description": "An instance of systemic lupus erythematosus (disease) that is caused by mutations in DNASE1L3."
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "SLEB16",
                "description": ""
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "systemic lupus erythematosus 16",
                "description": ""
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "systemic lupus erythematosus related to DNASE1L3",
                "description": ""
            },
            {
                "id": "MONDO:0013743",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013743",
                "name": "systemic lupus erythematosus type 16",
                "description": ""
            },
            {
                "id": "MIM:152700",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/152700",
                "name": "Systemic lupus erythematosus",
                "description": "Systemic lupus erythematosus"
            },
            {
                "id": "MIM:609939",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/609939",
                "name": "Systemic lupus erythematosus 6",
                "description": "Systemic lupus erythematosus 6"
            },
            {
                "id": "MIM:614420",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/614420",
                "name": "Systemic lupus erythematosus 16",
                "description": "Systemic lupus erythematosus 16"
            }
        ],
        "id": "DOID:9074"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased level of GalNAc on immunoglobulin G",
            "assessed_biomarker_entity_id": "P01825-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Immunoglobulin heavy variable 4-59",
                "synonyms": [
                    {
                        "synonym": "Ig heavy chain V-II region NEWM"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood serum",
                    "namespace": "UBERON",
                    "id": "0001977",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001977",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "BB3881-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/BB3881-1"
                },
                {
                    "id": "40187773",
                    "database": "PubMed",
                    "url": "",
                    "tags": [
                        "assessed_biomarker_entity_id",
                        " assessed_biomarker_entiy",
                        " assessed_entity_type",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "As for the WMOI group, glycan levels of lgG galactose (binding GHA), GalNAc (binding CSA) and Gal\u03b24GlcNAc (binding MAL I) were significantly lower than NPSLE and HC. For patients WMOI, lower binding levels were verified for GHA (preferred to Gal) than in NPSLE, and CSA (preferred to GalNAc) than in NPSLE or PAH."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": ""
        }
    ],
    "evidence_source": [
        {
            "id": "BB3881-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3881-1"
        },
        {
            "id": "40187773",
            "database": "PubMed",
            "url": "",
            "tags": [
                "condition"
            ],
            "evidence_list": [
                {
                    "evidence": "As for the WMOI group, glycan levels of lgG galactose (binding GHA), GalNAc (binding CSA) and Gal\u03b24GlcNAc (binding MAL I) were significantly lower than NPSLE and HC. For patients WMOI, lower binding levels were verified for GHA (preferred to Gal) than in NPSLE, and CSA (preferred to GalNAc) than in NPSLE or PAH."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "BB3881-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/BB3881-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
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            "table_id": "citation",
            "table_stats": [
                {
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            "sort_fields": []
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    ]
}