{
    "biomarker_id": "AN6718-2",
    "biomarker_canonical_id": "AN6718",
    "condition": {
        "recommended_name": {
            "id": "DOID:11934",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:11934",
            "name": "head and neck cancer",
            "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
        },
        "synonyms": [
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "head and neck neoplasm",
                "description": ""
            },
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "head and neck tumours",
                "description": ""
            },
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "head/neck neoplasm",
                "description": ""
            },
            {
                "id": "DOID:11934",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:11934",
                "name": "tumor of head and neck",
                "description": ""
            }
        ],
        "id": "DOID:11934"
    },
    "biomarker_component": [
        {
            "biomarker": "increased IL1B level",
            "assessed_biomarker_entity_id": "P01584-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Interleukin-1 beta",
                "synonyms": [
                    {
                        "synonym": "Catabolin"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "saliva",
                    "namespace": "UBERON",
                    "id": "0001836",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001836",
                    "loinc_code": "13629-1"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6718-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6718-2"
                },
                {
                    "id": "21109482",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/21109482",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "IL1B protein and IL8 protein as well as S100P mRNA were increased the most between all OSCC patients and controls with a fold change of 3.96, 3.09, and 3.24 respectively. Combined markers proved to be the strongest discriminator of OSCC with an AUC of 0.86 for all cancer patients (IL1B protein + SAT1 mRNA + DUSP1 mRNA), 0.85 for T1-T2 (IL1B mRNA + SAT1 mRNA + DUSP1 mRNA), and 0.88 for T3-T4 (IL1B protein + DUSP1 mRNA) (Figure 1\u00ac\u2020and\u00ac\u2020Table 3). The sensitivity/specificity for these groups were 0.89/0.78, 0.67/0.96, and 0.82/0.84 respectively."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6718-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6718-2"
        },
        {
            "id": "21109482",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/21109482",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "IL1B protein and IL8 protein as well as S100P mRNA were increased the most between all OSCC patients and controls with a fold change of 3.96, 3.09, and 3.24 respectively. Combined markers proved to be the strongest discriminator of OSCC with an AUC of 0.86 for all cancer patients (IL1B protein + SAT1 mRNA + DUSP1 mRNA), 0.85 for T1-T2 (IL1B mRNA + SAT1 mRNA + DUSP1 mRNA), and 0.88 for T3-T4 (IL1B protein + DUSP1 mRNA) (Figure 1\u00ac\u2020and\u00ac\u2020Table 3). The sensitivity/specificity for these groups were 0.89/0.78, 0.67/0.96, and 0.82/0.84 respectively."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6718-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6718-2",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population.",
            "journal": "Oral oncology",
            "authors": "Brinkmann O, Kastratovic DA, Dimitrijevic MV, Konstantinovic VS, Jelovac DB, Antic J, Nesic VS, Markovic SZ, Martinovic ZR, Akin D, Spielmann N, Zhou H, Wong DT",
            "date": "2011",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21109482",
                    "url": "https://glygen.org/publication/PubMed/21109482"
                }
            ],
            "evidence": [
                {
                    "id": "AN6372-6",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6718-2"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}