{
    "biomarker_id": "AN6711-1",
    "biomarker_canonical_id": "AN6711",
    "condition": {
        "recommended_name": {
            "id": "DOID:263",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:263",
            "name": "kidney cancer",
            "description": "A urinary system cancer that is located_in the kidney."
        },
        "synonyms": [
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant neoplasm of kidney except pelvis",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "malignant tumour of kidney",
                "description": ""
            },
            {
                "id": "DOID:263",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:263",
                "name": "renal cancer",
                "description": ""
            }
        ],
        "id": "DOID:263"
    },
    "biomarker_component": [
        {
            "biomarker": "decreased ALKBH5 level",
            "assessed_biomarker_entity_id": "Q6P6C2-2",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "RNA demethylase ALKBH5",
                "synonyms": [
                    {
                        "synonym": "Alkylated DNA repair protein alkB homolog 5"
                    },
                    {
                        "synonym": "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "kidney",
                    "namespace": "UBERON",
                    "id": "0002113",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002113",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6711-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6711-1"
                },
                {
                    "id": "31985880",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31985880",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "ALKBH5 was significantly reduced in RCC compared to normal tissue (P < 0.001), low expression levels of ALKBH5 and FTO were correlated with a shorter overall survival (OS: ALKBH5 log-rank P = 0.007; FTO log-rank P = 0.033) and cancer-specific survival (CSS: ALKBH5 log-rank P = 0.018; FTO log-rank P = 0.029"
                        }
                    ]
                },
                {
                    "id": "34683137",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/34683137",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": ". Univariate analysis showed that higher FTO expression was associated with better overall and progression free survival in both ccRCC and pRCC patients. No associations were disclosed concerning ALKBH5 expressions levels."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6711-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6711-1"
        },
        {
            "id": "31985880",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31985880",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "ALKBH5 was significantly reduced in RCC compared to normal tissue (P < 0.001), low expression levels of ALKBH5 and FTO were correlated with a shorter overall survival (OS: ALKBH5 log-rank P = 0.007; FTO log-rank P = 0.033) and cancer-specific survival (CSS: ALKBH5 log-rank P = 0.018; FTO log-rank P = 0.029"
                }
            ]
        },
        {
            "id": "34683137",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/34683137",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": ". Univariate analysis showed that higher FTO expression was associated with better overall and progression free survival in both ccRCC and pRCC patients. No associations were disclosed concerning ALKBH5 expressions levels."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6711-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6711-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "The N6 -methyladenosine (m6 A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity-associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma.",
            "journal": "BJU international",
            "authors": "Strick Alexander, von Hagen Felix, Gundert Larissa, Kl\u00fcmper Niklas, Tolkach Yuri, Schmidt Doris, Kristiansen Glen, Toma Marieta, Ritter Manuel, Ellinger J\u00f6rg",
            "date": "2020-04",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31985880",
                    "url": "https://glygen.org/publication/PubMed/31985880"
                }
            ],
            "evidence": [
                {
                    "id": "AN6710-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6711-1"
                }
            ]
        },
        {
            "title": "Deregulation of N6-Methyladenosine RNA Modification and Its Erasers FTO/ALKBH5 among the Main Renal Cell Tumor Subtypes.",
            "journal": "Journal of personalized medicine",
            "authors": "Guimar\u00e3es-Teixeira Catarina, Barros-Silva Daniela, Lobo Jo\u00e3o, Soares-Fernandes Diana, Const\u00e2ncio Vera, Leite-Silva Pedro, Silva-Santos Rui, Braga Isaac, Henrique Rui, Miranda-Gon\u00e7alves Vera, Jer\u00f3nimo Carmen",
            "date": "2021-09-30",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34683137",
                    "url": "https://glygen.org/publication/PubMed/34683137"
                }
            ],
            "evidence": [
                {
                    "id": "AN6711-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6711-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}