{
    "biomarker_id": "AN6596-1",
    "biomarker_canonical_id": "AN6596",
    "condition": {
        "recommended_name": {
            "id": "DOID:4159",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:4159",
            "name": "skin cancer",
            "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
        },
        "synonyms": [
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "CA - skin cancer",
                "description": ""
            },
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "malignant neoplasm of skin",
                "description": ""
            },
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "melanoma and Non-melanoma skin cancer",
                "description": ""
            }
        ],
        "id": "DOID:4159"
    },
    "biomarker_component": [
        {
            "biomarker": "increased CTSB level",
            "assessed_biomarker_entity_id": "P07858-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Cathepsin B",
                "synonyms": [
                    {
                        "synonym": "APP secretase"
                    },
                    {
                        "synonym": "APPS"
                    },
                    {
                        "synonym": "Cathepsin B1"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6596-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6596-1"
                },
                {
                    "id": "21673904",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/21673904",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Indeed, significantly elevated levels of Cathepsin B (as determined by unpaired t test) were observed in melanoma patients. However, Cathepsin B levels were also elevated in breast cancer patients, indicating that cathepsin B is not unique to melanoma but may be associated with general tumor progression. Cathepsin B levels were also independent of age and stages of melanoma. In our study, serum cathepsin B levels were elevated in both melanoma and breast cancer patients. Based on these data, it is suggested that cathepsin B might be relevant to the development of a broad range of tumor, possibly contributing to the tumor cell migration and metastasis due to its protease function."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6596-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6596-1"
        },
        {
            "id": "21673904",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/21673904",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Indeed, significantly elevated levels of Cathepsin B (as determined by unpaired t test) were observed in melanoma patients. However, Cathepsin B levels were also elevated in breast cancer patients, indicating that cathepsin B is not unique to melanoma but may be associated with general tumor progression. Cathepsin B levels were also independent of age and stages of melanoma. In our study, serum cathepsin B levels were elevated in both melanoma and breast cancer patients. Based on these data, it is suggested that cathepsin B might be relevant to the development of a broad range of tumor, possibly contributing to the tumor cell migration and metastasis due to its protease function."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6596-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6596-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "IL-8 and cathepsin B as melanoma serum biomarkers.",
            "journal": "International journal of molecular sciences",
            "authors": "Zhang H, Fu T, McGettigan S, Kumar S, Liu S, Speicher D, Schuchter L, Xu X",
            "date": "2011",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21673904",
                    "url": "https://glygen.org/publication/PubMed/21673904"
                }
            ],
            "evidence": [
                {
                    "id": "AN6372-3",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6596-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}