{
    "biomarker_id": "AN6595-1",
    "biomarker_canonical_id": "AN6595",
    "condition": {
        "recommended_name": {
            "id": "DOID:4159",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:4159",
            "name": "skin cancer",
            "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
        },
        "synonyms": [
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "CA - skin cancer",
                "description": ""
            },
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "malignant neoplasm of skin",
                "description": ""
            },
            {
                "id": "DOID:4159",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:4159",
                "name": "melanoma and Non-melanoma skin cancer",
                "description": ""
            }
        ],
        "id": "DOID:4159"
    },
    "biomarker_component": [
        {
            "biomarker": "increased CXCR4 level",
            "assessed_biomarker_entity_id": "P61073-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "C-X-C chemokine receptor type 4",
                "synonyms": [
                    {
                        "synonym": "Leukocyte-derived seven transmembrane domain receptor"
                    },
                    {
                        "synonym": "LESTR"
                    },
                    {
                        "synonym": "Lipopolysaccharide-associated protein 3"
                    },
                    {
                        "synonym": "LAP-3"
                    },
                    {
                        "synonym": "LPS-associated protein 3"
                    },
                    {
                        "synonym": "Stromal cell-derived factor 1 receptor"
                    },
                    {
                        "synonym": "SDF-1 receptor"
                    },
                    {
                        "synonym": "HM89"
                    },
                    {
                        "synonym": "FB22"
                    },
                    {
                        "synonym": "NPYRL"
                    },
                    {
                        "synonym": "LCR1"
                    },
                    {
                        "synonym": "Fusin"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "skin epidermis",
                    "namespace": "UBERON",
                    "id": "0001003",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001003",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6595-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6595-1"
                },
                {
                    "id": "15756007",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/15756007",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The CXCR4 expression on tumor cells was correlated with an unfavorable prognosis with a median disease-free and overall survival of 22 and 35 months, respectively. The hazard ratios of relapse and death, compared with patients with CXCR4-negative tumors, were 2.5 (95% confidence interval, 1.2-6.1) and 3.1 (95% confidence interval, 1.1-7.2), respectively. This article provides the first evidence that CXCR4 expression could be an independent and powerful prognostic marker in primary cutaneous malignant melanomas."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6595-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6595-1"
        },
        {
            "id": "15756007",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/15756007",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The CXCR4 expression on tumor cells was correlated with an unfavorable prognosis with a median disease-free and overall survival of 22 and 35 months, respectively. The hazard ratios of relapse and death, compared with patients with CXCR4-negative tumors, were 2.5 (95% confidence interval, 1.2-6.1) and 3.1 (95% confidence interval, 1.1-7.2), respectively. This article provides the first evidence that CXCR4 expression could be an independent and powerful prognostic marker in primary cutaneous malignant melanomas."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6595-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6595-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma.",
            "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research",
            "authors": "Scala S, Ottaiano A, Ascierto PA, Cavalli M, Simeone E, Giuliano P, Napolitano M, Franco R, Botti G, Castello G",
            "date": "2005",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15756007",
                    "url": "https://glygen.org/publication/PubMed/15756007"
                }
            ],
            "evidence": [
                {
                    "id": "AN6592-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6595-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}