{
    "biomarker_id": "AN6503-1",
    "biomarker_canonical_id": "AN6503",
    "condition": {
        "recommended_name": {
            "id": "DOID:1793",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1793",
            "name": "pancreatic cancer",
            "description": "An endocrine gland cancer located_in the pancreas."
        },
        "synonyms": [
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca body of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca head of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "Ca tail of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of body of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of head of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "malignant neoplasm of tail of pancreas",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreas neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreatic neoplasm",
                "description": ""
            },
            {
                "id": "DOID:1793",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1793",
                "name": "pancreatic tumor",
                "description": ""
            }
        ],
        "id": "DOID:1793"
    },
    "biomarker_component": [
        {
            "biomarker": "increased GDF15 level",
            "assessed_biomarker_entity_id": "Q99988-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Growth/differentiation factor 15",
                "synonyms": [
                    {
                        "synonym": "Macrophage inhibitory cytokine 1"
                    },
                    {
                        "synonym": "MIC-1"
                    },
                    {
                        "synonym": "NSAID-activated gene 1 protein"
                    },
                    {
                        "synonym": "NAG-1"
                    },
                    {
                        "synonym": "NSAID-regulated gene 1 protein"
                    },
                    {
                        "synonym": "NRG-1"
                    },
                    {
                        "synonym": "Prostate differentiation factor"
                    },
                    {
                        "synonym": "Placental TGF-beta"
                    },
                    {
                        "synonym": "Placental bone morphogenetic protein"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6503-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6503-1"
                },
                {
                    "id": "16428484",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/16428484",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Ninety percent of patients with pancreatic cancer had MIC-1 levels >2 SD above age-matched controls. By logistic regression analysis, MIC-1 and CA19-9 were significant independent predictors of diagnosis. Receiver operating characteristic curve analysis showed that MIC-1 was significantly better than CA19-9 in differentiating patients with pancreatic cancer from healthy controls (area under the curve is 0.99 and 0.78, respectively; P = 0.003), but not in distinguishing pancreatic cancer from chronic pancreatitis (area under the curve of 0.81 and 0.74, respectively; P = 0.63). In the differentiation of patients with resectable pancreatic cancer from controls, serum MIC-1 outperforms other markers including CA19-9."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6503-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6503-1"
        },
        {
            "id": "16428484",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/16428484",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Ninety percent of patients with pancreatic cancer had MIC-1 levels >2 SD above age-matched controls. By logistic regression analysis, MIC-1 and CA19-9 were significant independent predictors of diagnosis. Receiver operating characteristic curve analysis showed that MIC-1 was significantly better than CA19-9 in differentiating patients with pancreatic cancer from healthy controls (area under the curve is 0.99 and 0.78, respectively; P = 0.003), but not in distinguishing pancreatic cancer from chronic pancreatitis (area under the curve of 0.81 and 0.74, respectively; P = 0.63). In the differentiation of patients with resectable pancreatic cancer from controls, serum MIC-1 outperforms other markers including CA19-9."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6503-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6503-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Serum markers in patients with resectable pancreatic adenocarcinoma: macrophage inhibitory cytokine 1 versus CA19-9.",
            "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research",
            "authors": "Koopmann J, Rosenzweig CN, Zhang Z, Canto MI, Brown DA, Hunter M, Yeo C, Chan DW, Breit SN, Goggins M",
            "date": "2006",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16428484",
                    "url": "https://glygen.org/publication/PubMed/16428484"
                }
            ],
            "evidence": [
                {
                    "id": "AN6501-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6503-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}