{
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    "biomarker_canonical_id": "AN6483",
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            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:3571",
            "name": "liver cancer",
            "description": "A hepatobiliary system cancer that is located_in the liver."
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        "synonyms": [
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                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "Ca liver - primary",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "Resectable malignant neoplasm of Liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "hepatic cancer",
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            },
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                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "hepatic neoplasm",
                "description": ""
            },
            {
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                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
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                "description": ""
            },
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                "id": "DOID:3571",
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                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant tumor of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "non-resectable primary hepatic malignant neoplasm",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "primary liver cancer",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "primary malignant neoplasm of liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "resectable malignant neoplasm of the liver",
                "description": ""
            },
            {
                "id": "DOID:3571",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:3571",
                "name": "malignant neoplasm of liver, not specified as primary or secondary",
                "description": ""
            }
        ],
        "id": "DOID:3571"
    },
    "biomarker_component": [
        {
            "biomarker": "increased GATA-4 level",
            "assessed_biomarker_entity_id": "P43694-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Transcription factor GATA-4",
                "synonyms": [
                    {
                        "synonym": "GATA-binding factor 4"
                    }
                ]
            },
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                {
                    "name": "liver",
                    "namespace": "UBERON",
                    "id": "0002107",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0002107",
                    "loinc_code": ""
                }
            ],
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                    "database": "BiomarkerKB",
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                },
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                    "url": "https://glygen.org/publication/PubMed/27788486",
                    "tags": [
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                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "This GATA4/miR125b/DKK3 axis may be a major regulator of growth, migration, invasion, and survival in hepatoma cells, and is therefore a potential therapeutic target or biomarker for progression in HB patients. GATA4 expression and activity were high in liver tumors in children, but not in adults."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6483-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6483-1"
        },
        {
            "id": "27788486",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/27788486",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "This GATA4/miR125b/DKK3 axis may be a major regulator of growth, migration, invasion, and survival in hepatoma cells, and is therefore a potential therapeutic target or biomarker for progression in HB patients. GATA4 expression and activity were high in liver tumors in children, but not in adults."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6483-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6483-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "GATA4 promotes hepatoblastoma cell proliferation by altering expression of miR125b and DKK3.",
            "journal": "Oncotarget",
            "authors": "Pei Y, Yao Q, Yuan S, Xie B, Liu Y, Ye C, Zhuo H",
            "date": "2016",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27788486",
                    "url": "https://glygen.org/publication/PubMed/27788486"
                }
            ],
            "evidence": [
                {
                    "id": "AN6482-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6483-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
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                    "count": 1
                }
            ],
            "sort_fields": [
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                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
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}