{
    "biomarker_id": "AN6442-2",
    "biomarker_canonical_id": "AN6442",
    "condition": {
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            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:9256",
            "name": "colorectal cancer",
            "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
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            },
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                "description": ""
            },
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                "description": ""
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            {
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                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
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                "name": "colon cancer, advanced, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "colon cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "colorectal cancer",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
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                "description": ""
            },
            {
                "id": "MONDO:0005575",
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                "description": ""
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            {
                "id": "MONDO:0005575",
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                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "colorectum cancer",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant colorectal neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant colorectal tumor",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant colorectal tumour",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant colorectum neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant large bowel neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant large bowel tumor",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant large bowel tumour",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant large intestine neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant large intestine tumor",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant large intestine tumour",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
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                "name": "malignant neoplasm of colorectum",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant neoplasm of large bowel",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant neoplasm of large intestine",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant neoplasm of the large bowel",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant neoplasm of the large intestine",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant tumor of large bowel",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
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                "name": "malignant tumor of large intestine",
                "description": ""
            },
            {
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                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant tumor of the large bowel",
                "description": ""
            },
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                "id": "MONDO:0005575",
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                "name": "malignant tumor of the large intestine",
                "description": ""
            },
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                "id": "MONDO:0005575",
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                "name": "malignant tumour of large bowel",
                "description": ""
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                "name": "malignant tumour of large intestine",
                "description": ""
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            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
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                "name": "malignant tumour of the large bowel",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "malignant tumour of the large intestine",
                "description": ""
            },
            {
                "id": "MONDO:0005575",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0005575",
                "name": "CRC",
                "description": ""
            },
            {
                "id": "MIM:114500",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/114500",
                "name": "Colorectal cancer",
                "description": "Colorectal cancer"
            }
        ],
        "id": "DOID:9256"
    },
    "biomarker_component": [
        {
            "biomarker": "increased LGALS3 level",
            "assessed_biomarker_entity_id": "P17931-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Galectin-3",
                "synonyms": [
                    {
                        "synonym": "Galactoside-binding protein"
                    },
                    {
                        "synonym": "GALBP"
                    },
                    {
                        "synonym": "Carbohydrate-binding protein 35"
                    },
                    {
                        "synonym": "CBP 35"
                    },
                    {
                        "synonym": "Lectin L-29"
                    },
                    {
                        "synonym": "IgE-binding protein"
                    },
                    {
                        "synonym": "Mac-2 antigen"
                    },
                    {
                        "synonym": "L-31"
                    },
                    {
                        "synonym": "35 kDa lectin"
                    },
                    {
                        "synonym": "Laminin-binding protein"
                    },
                    {
                        "synonym": "Galactose-specific lectin 3"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "colon",
                    "namespace": "UBERON",
                    "id": "0001155",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0001155",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6442-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6442-2"
                },
                {
                    "id": "28085015",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/28085015",
                    "tags": [
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                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "High expression of tumoral gal-3 was associated with tumor size, poor differentiation and negatively related to low E-cadherin expression. Multivariate analysis revealed that tumoral gal-3 expression was the only independent predictor of both tumor recurrence and overall survival after resection."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6442-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6442-2"
        },
        {
            "id": "28085015",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/28085015",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "High expression of tumoral gal-3 was associated with tumor size, poor differentiation and negatively related to low E-cadherin expression. Multivariate analysis revealed that tumoral gal-3 expression was the only independent predictor of both tumor recurrence and overall survival after resection."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6442-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6442-2",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Over expression of galectin-3 associates with short-term poor prognosis in stage II colon cancer.",
            "journal": "Cancer biomarkers : section A of Disease markers",
            "authors": "Huang Z, Ai Z, Li N, Xi H, Gao X, Wang F, Tan X, Liu H",
            "date": "2016",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28085015",
                    "url": "https://glygen.org/publication/PubMed/28085015"
                }
            ],
            "evidence": [
                {
                    "id": "AN6444-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6442-2"
                }
            ]
        }
    ],
    "section_stats": [
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                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
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                "assessed_biomarker_entity_id",
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                "assessed_biomarker_entity.recommended_name"
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}