{
    "biomarker_id": "AN6402-1",
    "biomarker_canonical_id": "AN6402",
    "condition": {
        "recommended_name": {
            "id": "DOID:1612",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1612",
            "name": "breast cancer",
            "description": "An organ system cancer that originates in the mammary gland."
        },
        "synonyms": [
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "breast tumor",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "malignant neoplasm of breast",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "malignant tumor of the breast",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "mammary cancer",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "mammary tumor",
                "description": ""
            },
            {
                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "primary breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast carcinoma",
                "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, lobular, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial breast carcinoma",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial cancer of breast",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial cancer of the breast",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast carcinoma",
                "description": ""
            },
            {
                "id": "MIM:114480",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/114480",
                "name": "Breast cancer",
                "description": "Breast cancer"
            }
        ],
        "id": "DOID:1612"
    },
    "biomarker_component": [
        {
            "biomarker": "increased CSF1 level",
            "assessed_biomarker_entity_id": "P09603-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Macrophage colony-stimulating factor 1",
                "synonyms": [
                    {
                        "synonym": "Lanimostim"
                    },
                    {
                        "synonym": "Proteoglycan macrophage colony-stimulating factor"
                    },
                    {
                        "synonym": "PG-M-CSF"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6402-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6402-1"
                },
                {
                    "id": "23688065",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/23688065",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Macrophage-colony stimulating factor (M-CSF) regulates growth and differentiation of hematopoietic progenitor cells and functionally activates the maturation of macrophages. The M-CSF in breast cancer patients were investigated and compared with control groups. The medians of M-CSF, which was 464.28 pg/ml in its levels similarly to the level of the commonly accepted tumor marker, which is CA 15-3 at 25.00 U/ml in the total group of breast cancer patients were significantly higher when compared to the healthy subjects, which is 298.55 pg/ml (p < 0.001). In other words, the median levels of M-CSF in breast cancer total group were statistically higher than in benign breast tumor patients group (p = 0.0004)."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "diagnostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6402-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6402-1"
        },
        {
            "id": "23688065",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/23688065",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Macrophage-colony stimulating factor (M-CSF) regulates growth and differentiation of hematopoietic progenitor cells and functionally activates the maturation of macrophages. The M-CSF in breast cancer patients were investigated and compared with control groups. The medians of M-CSF, which was 464.28 pg/ml in its levels similarly to the level of the commonly accepted tumor marker, which is CA 15-3 at 25.00 U/ml in the total group of breast cancer patients were significantly higher when compared to the healthy subjects, which is 298.55 pg/ml (p < 0.001). In other words, the median levels of M-CSF in breast cancer total group were statistically higher than in benign breast tumor patients group (p = 0.0004)."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6402-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6402-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "VEGF, M-CSF and CA 15-3 as a new tumor marker panel in breast malignancies: a multivariate analysis with ROC curve.",
            "journal": "Growth factors (Chur, Switzerland)",
            "authors": "Lawicki S, Bedkowska GE, Szmitkowski M",
            "date": "2013",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23688065",
                    "url": "https://glygen.org/publication/PubMed/23688065"
                }
            ],
            "evidence": [
                {
                    "id": "AN6400-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6402-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}