{
    "biomarker_id": "AN6322-1",
    "biomarker_canonical_id": "AN6322",
    "condition": {
        "recommended_name": {
            "id": "DOID:363",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:363",
            "name": "uterine cancer",
            "description": "A female reproductive organ cancer that is located_in the uterus."
        },
        "synonyms": [
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "CA - cancer of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "Tumour of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "malignant neoplasm of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "malignant uterine tumor",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "neoplasm of uterus",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "uterine tumor",
                "description": ""
            },
            {
                "id": "DOID:363",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:363",
                "name": "uterus neoplasm",
                "description": ""
            }
        ],
        "id": "DOID:363"
    },
    "biomarker_component": [
        {
            "biomarker": "increased MUC16 level",
            "assessed_biomarker_entity_id": "Q8WXI7-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Mucin-16",
                "synonyms": [
                    {
                        "synonym": "Ovarian cancer-related tumor marker CA125"
                    },
                    {
                        "synonym": "CA-125"
                    },
                    {
                        "synonym": "Ovarian carcinoma antigen CA125"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "uterus",
                    "namespace": "UBERON",
                    "id": "0000995",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000995",
                    "loinc_code": "10334-1"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6322-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6322-1"
                },
                {
                    "id": "29958235",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/29958235",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The median levels of CA-125 were 9 to 14 times higher for each parameter that demonstrated extrauterine metastasis (all with P < 0.001). Levels of CA-125 were significantly associated with positive cytology (P < 0.0001), omental disease (P < 0.0001), pelvic or para-aortic lymph node metastasis (P < 0.0001), and adnexal involvement (P < 0.0001)."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "predictive"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6322-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6322-1"
        },
        {
            "id": "29958235",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/29958235",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The median levels of CA-125 were 9 to 14 times higher for each parameter that demonstrated extrauterine metastasis (all with P < 0.001). Levels of CA-125 were significantly associated with positive cytology (P < 0.0001), omental disease (P < 0.0001), pelvic or para-aortic lymph node metastasis (P < 0.0001), and adnexal involvement (P < 0.0001)."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6322-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6322-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Cancer Antigen 125 Levels are Significantly Associated With Prognostic Parameters in Uterine Papillary Serous Carcinoma.",
            "journal": "International journal of gynecological cancer : official journal of the International Gynecological Cancer Society",
            "authors": "Schmidt M, Segev Y, Sadeh R, Suzan E, Feferkorn I, Kaldawy A, Kligun G, Lavie O",
            "date": "2018",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29958235",
                    "url": "https://glygen.org/publication/PubMed/29958235"
                }
            ],
            "evidence": [
                {
                    "id": "AN6746-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6322-1"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}