{
    "biomarker_id": "AN6307-2",
    "biomarker_canonical_id": "AN6307",
    "condition": {
        "recommended_name": {
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            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:2394",
            "name": "ovarian cancer",
            "description": "A female reproductive organ cancer that is located_in the ovary."
        },
        "synonyms": [
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "malignant Ovarian tumor",
                "description": ""
            },
            {
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                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "malignant tumour of ovary",
                "description": ""
            },
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                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "ovarian neoplasm",
                "description": ""
            },
            {
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                "name": "ovary neoplasm",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "primary ovarian cancer",
                "description": ""
            },
            {
                "id": "DOID:2394",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:2394",
                "name": "tumor of the Ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer",
                "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas."
            },
            {
                "id": "MONDO:0008170",
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                "name": "ovarian neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
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                "description": ""
            },
            {
                "id": "MONDO:0008170",
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                "name": "tumor of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "tumour of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "cancer of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "cancer of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant neoplasm of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant neoplasm of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian tumor",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovarian tumour",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant ovary neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumor of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumor of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumour of ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "malignant tumour of the ovary",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian malignant tumor",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovarian malignant tumour",
                "description": ""
            },
            {
                "id": "MONDO:0008170",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008170",
                "name": "ovary cancer",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to, 1",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "OVCAS1",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to",
                "description": ""
            },
            {
                "id": "MONDO:0011931",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0011931",
                "name": "ovarian cancer, susceptibility to, 1",
                "description": ""
            },
            {
                "id": "MIM:167000",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/167000",
                "name": "Ovarian cancer",
                "description": "Ovarian cancer"
            }
        ],
        "id": "DOID:2394"
    },
    "biomarker_component": [
        {
            "biomarker": "increased PLAUR level",
            "assessed_biomarker_entity_id": "Q03405-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Urokinase plasminogen activator surface receptor",
                "synonyms": [
                    {
                        "synonym": "Monocyte activation antigen Mo3"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "17204-9"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6307-2",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6307-2"
                },
                {
                    "id": "9581823",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/9581823",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "The median suPAR levels found in each patient group were significantly higher than in the control group. Both ovarian and nonovarian malignant carcinoma subgroups showed a 2-fold increase of suPAR compared to controls. This study shows that the level of the soluble receptor for uPA, a proteinase that is considered to play a key role in physiological and malignant invasion, is increased in serum of a subgroup of ovarian carcinoma patients. Moreover, patients with high suPAR levels showed significantly worse prognosis in survival analysis."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6307-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6307-2"
        },
        {
            "id": "9581823",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/9581823",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The median suPAR levels found in each patient group were significantly higher than in the control group. Both ovarian and nonovarian malignant carcinoma subgroups showed a 2-fold increase of suPAR compared to controls. This study shows that the level of the soluble receptor for uPA, a proteinase that is considered to play a key role in physiological and malignant invasion, is increased in serum of a subgroup of ovarian carcinoma patients. Moreover, patients with high suPAR levels showed significantly worse prognosis in survival analysis."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6307-2",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6307-2",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "The level of urokinase-type plasminogen activator receptor is increased in serum of ovarian cancer patients.",
            "journal": "Cancer research",
            "authors": "Sier CF, Stephens R, Bizik J, Mariani A, Bassan M, Pedersen N, Frigerio L, Ferrari A, Dano K, Brunner N, Blasi F",
            "date": "1998",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9581823",
                    "url": "https://glygen.org/publication/PubMed/9581823"
                }
            ],
            "evidence": [
                {
                    "id": "AN6307-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6307-2"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
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                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
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                    "count": 1
                }
            ],
            "sort_fields": [
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                "journal",
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        }
    ]
}