{
    "biomarker_id": "AN6294-1",
    "biomarker_canonical_id": "AN6294",
    "condition": {
        "recommended_name": {
            "id": "DOID:1324",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:1324",
            "name": "lung cancer",
            "description": "A respiratory system cancer that is located_in the lung."
        },
        "synonyms": [
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                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
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                "description": "A malignant neoplasm involving the lung."
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "adenocarcinoma of lung, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "cancer of lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
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                "name": "lung cancer",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
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                "name": "lung cancer, protection against, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
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                "description": ""
            },
            {
                "id": "MONDO:0008903",
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                "name": "lung cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant lung neoplasm",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant lung tumor",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant lung tumour",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant neoplasm of lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant neoplasm of the lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant tumor of lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant tumor of the lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant tumour of lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "malignant tumour of the lung",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "nonsmall cell lung cancer, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0008903",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0012159",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                "name": "lung cancer susceptibility 1",
                "description": ""
            },
            {
                "id": "MONDO:0012159",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                "name": "LNCR1",
                "description": ""
            },
            {
                "id": "MONDO:0012159",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                "name": "lung cancer susceptibility",
                "description": ""
            },
            {
                "id": "MONDO:0012159",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                "name": "lung cancer susceptibility 1",
                "description": ""
            },
            {
                "id": "MONDO:0012942",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                "name": "lung cancer susceptibility 3",
                "description": ""
            },
            {
                "id": "MONDO:0012942",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                "name": "LNCR3",
                "description": ""
            },
            {
                "id": "MONDO:0012942",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                "name": "lung cancer susceptibility 3",
                "description": ""
            },
            {
                "id": "MONDO:0012955",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                "name": "lung cancer susceptibility 4",
                "description": ""
            },
            {
                "id": "MONDO:0012955",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                "name": "LNCR4",
                "description": ""
            },
            {
                "id": "MONDO:0012955",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                "name": "lung cancer susceptibility 4",
                "description": ""
            },
            {
                "id": "MONDO:0013631",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                "name": "lung cancer susceptibility 5",
                "description": ""
            },
            {
                "id": "MONDO:0013631",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                "name": "LNCR5",
                "description": ""
            },
            {
                "id": "MONDO:0013631",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                "name": "lung cancer susceptibility 5",
                "description": ""
            },
            {
                "id": "MIM:211980",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/211980",
                "name": "Lung cancer",
                "description": "Lung cancer"
            }
        ],
        "id": "DOID:1324"
    },
    "biomarker_component": [
        {
            "biomarker": "increased levels of SAA1",
            "assessed_biomarker_entity_id": "P0DJI8-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Serum amyloid A-1 protein",
                "synonyms": [
                    {
                        "synonym": "Amyloid fibril protein AA"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": ""
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6294-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6294-1"
                },
                {
                    "id": "12973732",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/12973732",
                    "tags": [
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                        " assessed_biomarker_entiy",
                        " assessed_entity_type",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": ""
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                    ]
                },
                {
                    "id": "20502455",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/20502455",
                    "tags": [
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                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Study detected increased SAA level in the serum of lung cancer patients and also identified that elevated SAA level may be a non-invasive biomarker useful for the prediction of lung cancer prognosis. A differential protein with m/z 11.6 kDa was detected and identified as an isoform of human serum amyloid A (SAA). It was significantly increased by 1822% in lung cancer patients when compared with the healthy controls, which gave an area under the receiver operator characteristic curve of 0.88. In addition, the protein was also significantly elevated by 77% in lung cancer patients with survival <5 years when compared with patients with survival >/=5 years."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "risk"
        },
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6294-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6294-1"
        },
        {
            "id": "12973732",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/12973732",
            "tags": [
                "condition"
            ],
            "evidence_list": [
                {
                    "evidence": ""
                }
            ]
        },
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            "id": "20502455",
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            "url": "https://glygen.org/publication/PubMed/20502455",
            "tags": [
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                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Study detected increased SAA level in the serum of lung cancer patients and also identified that elevated SAA level may be a non-invasive biomarker useful for the prediction of lung cancer prognosis. A differential protein with m/z 11.6 kDa was detected and identified as an isoform of human serum amyloid A (SAA). It was significantly increased by 1822% in lung cancer patients when compared with the healthy controls, which gave an area under the receiver operator characteristic curve of 0.88. In addition, the protein was also significantly elevated by 77% in lung cancer patients with survival <5 years when compared with patients with survival >/=5 years."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6294-1",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6294-1",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Identification and validation of a potential lung cancer serum biomarker detected by matrix-assisted laser desorption/ionization-time of flight spectra analysis.",
            "journal": "Proteomics",
            "authors": "Howard Brandon A, Wang Michael Z, Campa Michael J, Corro Christina, Fitzgerald Michael C, Patz Edward F",
            "date": "2003-09",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12973732",
                    "url": "https://glygen.org/publication/PubMed/12973732"
                }
            ],
            "evidence": [
                {
                    "id": "BB1498-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6294-1"
                }
            ]
        },
        {
            "title": "Serum amyloid A is elevated in the serum of lung cancer patients with poor prognosis.",
            "journal": "British journal of cancer",
            "authors": "Cho WC, Yip TT, Cheng WW, Au JS",
            "date": "2010",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20502455",
                    "url": "https://glygen.org/publication/PubMed/20502455"
                }
            ],
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                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6294-1"
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        }
    ],
    "section_stats": [
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}