{
    "biomarker_id": "AN6278-4",
    "biomarker_canonical_id": "AN6278",
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            "resource": "Disease Ontology",
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            {
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                "resource": "Disease Ontology",
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                "description": ""
            },
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                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "mammary cancer",
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            },
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                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "mammary tumor",
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            },
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                "id": "DOID:1612",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:1612",
                "name": "primary breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
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                "name": "hereditary breast carcinoma",
                "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
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                "id": "MONDO:0016419",
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                "description": ""
            },
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                "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, lobular, somatic",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
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                "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                "description": ""
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                "id": "MONDO:0016419",
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                "name": "breast cancer, somatic",
                "description": ""
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                "description": ""
            },
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                "id": "MONDO:0016419",
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                "description": ""
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                "id": "MONDO:0016419",
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                "name": "familial breast carcinoma",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial cancer of breast",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "familial cancer of the breast",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                "name": "hereditary breast cancer",
                "description": ""
            },
            {
                "id": "MONDO:0016419",
                "resource": "MONDO",
                "url": "https://monarchinitiative.org/disease/MONDO:0016419",
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                "description": ""
            },
            {
                "id": "MIM:114480",
                "resource": "MIM",
                "url": "https://www.omim.org/entry/114480",
                "name": "Breast cancer",
                "description": "Breast cancer"
            }
        ],
        "id": "DOID:1612"
    },
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        {
            "biomarker": "increased IL6 level",
            "assessed_biomarker_entity_id": "P05231-1",
            "assessed_entity_type": "protein",
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                    {
                        "synonym": "Interferon beta-2"
                    },
                    {
                        "synonym": "IFN-beta-2"
                    },
                    {
                        "synonym": "CTL differentiation factor"
                    },
                    {
                        "synonym": "CDF"
                    },
                    {
                        "synonym": "B-cell stimulatory factor 2"
                    },
                    {
                        "synonym": "BSF-2"
                    },
                    {
                        "synonym": "Hybridoma growth factor"
                    }
                ]
            },
            "specimen": [
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                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
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                    ],
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                        {
                            "evidence": "The study showed that IL-6, IL-8 and TNF-alpha levels correlated with clinical disease stage and lymph node metastasis as well as with ER and HER2 antigen expression. Specifically, IL-6 and IL-8 seem to have significant potential as prognostic cancer biomarkers."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "prognostic"
        }
    ],
    "evidence_source": [
        {
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            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6278-4"
        },
        {
            "id": "28791816",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/28791816",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "The study showed that IL-6, IL-8 and TNF-alpha levels correlated with clinical disease stage and lymph node metastasis as well as with ER and HER2 antigen expression. Specifically, IL-6 and IL-8 seem to have significant potential as prognostic cancer biomarkers."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6278-4",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6278-4",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "IL-6, IL-8 and TNF-alpha levels correlate with disease stage in breast cancer patients.",
            "journal": "Advances in clinical and experimental medicine : official organ Wroclaw Medical University",
            "authors": "Ma Y, Ren Y, Dai ZJ, Wu CJ, Ji YH, Xu J",
            "date": "2017",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28791816",
                    "url": "https://glygen.org/publication/PubMed/28791816"
                }
            ],
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                {
                    "id": "AN6278-5",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6278-4"
                }
            ]
        }
    ],
    "section_stats": [
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            ],
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}