{
    "biomarker_id": "AN6278-3",
    "biomarker_canonical_id": "AN6278",
    "condition": {
        "recommended_name": {
            "id": "DOID:0080846",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080846",
            "name": "latent autoimmune diabetes in adults",
            "description": "A type 1 diabetes mellitus that is characterized by a less intensive autoimmune process, highly variable -cell destruction, different degrees of insulin resistance and heterogeneous titre and pattern of islet autoantibody, sharing features with both type 1 and type 2 diabetes mellitus."
        },
        "synonyms": [
            {
                "id": "DOID:0080846",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080846",
                "name": "LADA",
                "description": ""
            },
            {
                "id": "DOID:0080846",
                "resource": "Disease Ontology",
                "url": "https://disease-ontology.org/term/DOID:0080846",
                "name": "type 1.5 diabetes",
                "description": ""
            }
        ],
        "id": "DOID:0080846"
    },
    "biomarker_component": [
        {
            "biomarker": "increased IL6 level",
            "assessed_biomarker_entity_id": "P05231-1",
            "assessed_entity_type": "protein",
            "assessed_biomarker_entity": {
                "recommended_name": "Interleukin-6",
                "synonyms": [
                    {
                        "synonym": "Interferon beta-2"
                    },
                    {
                        "synonym": "IFN-beta-2"
                    },
                    {
                        "synonym": "CTL differentiation factor"
                    },
                    {
                        "synonym": "CDF"
                    },
                    {
                        "synonym": "B-cell stimulatory factor 2"
                    },
                    {
                        "synonym": "BSF-2"
                    },
                    {
                        "synonym": "Hybridoma growth factor"
                    }
                ]
            },
            "specimen": [
                {
                    "name": "blood",
                    "namespace": "UBERON",
                    "id": "0000178",
                    "url": "http://purl.obolibrary.org/obo/UBERON_0000178",
                    "loinc_code": "26881-3"
                }
            ],
            "evidence_source": [
                {
                    "id": "AN6278-3",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6278-3"
                },
                {
                    "id": "31772933",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31772933",
                    "tags": [
                        "assessed_biomarker_entity",
                        " biomarker",
                        " specimen"
                    ],
                    "evidence_list": [
                        {
                            "evidence": "Significantly higher IL-15 and IL-6 concentrations, HOMAIR, and markedly lower eGDR in newly diagnosed AD patients and first-degree relatives with positive anti-islet antibodies might suggest the role of these pro-inflammatory cytokines and insulin resistance in the pathogenesis of autoimmune diabetes. IL-15 and IL-6 might be used as biomarkers of the risk of autoimmune diabetes development."
                        }
                    ]
                }
            ]
        }
    ],
    "best_biomarker_role": [
        {
            "role": "risk"
        }
    ],
    "evidence_source": [
        {
            "id": "AN6278-3",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6278-3"
        },
        {
            "id": "31772933",
            "database": "PubMed",
            "url": "https://glygen.org/publication/PubMed/31772933",
            "tags": [
                "best_biomarker_role",
                " condition"
            ],
            "evidence_list": [
                {
                    "evidence": "Significantly higher IL-15 and IL-6 concentrations, HOMAIR, and markedly lower eGDR in newly diagnosed AD patients and first-degree relatives with positive anti-islet antibodies might suggest the role of these pro-inflammatory cytokines and insulin resistance in the pathogenesis of autoimmune diabetes. IL-15 and IL-6 might be used as biomarkers of the risk of autoimmune diabetes development."
                }
            ]
        }
    ],
    "crossref": [
        {
            "id": "AN6278-3",
            "database": "BiomarkerKB",
            "url": "https://biomarkerkb.org/biomarker/AN6278-3",
            "categories": [
                "Biomarkers"
            ]
        }
    ],
    "citation": [
        {
            "title": "Interleukin-6 and Interleukin-15 as Possible Biomarkers of the Risk of Autoimmune Diabetes Development.",
            "journal": "BioMed research international",
            "authors": "Siewko K, Maciulewski R, Zielinska-Maciulewska A, Poplawska-Kita A, Szumowski P, Wawrusiewicz-Kurylonek N, Lipinska D, Milewski R, Gorska M, Kretowski A, Szelachowska M",
            "date": "2019",
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31772933",
                    "url": "https://glygen.org/publication/PubMed/31772933"
                }
            ],
            "evidence": [
                {
                    "id": "AN6278-1",
                    "database": "BiomarkerKB",
                    "url": "https://biomarkerkb.org/biomarker/AN6278-3"
                }
            ]
        }
    ],
    "section_stats": [
        {
            "table_id": "biomarker_component",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "biomarker",
                "assessed_biomarker_entity_id",
                "assessed_entity_type",
                "assessed_biomarker_entity.recommended_name"
            ]
        },
        {
            "table_id": "citation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "authors",
                "date"
            ]
        }
    ]
}