{
    "uniprot_canonical_ac": "A0A193KX02-1",
    "uniprot_id": [
        {
            "id": "TOMT_DANRE",
            "url": "https://www.uniprot.org/uniprot/A0A193KX02",
            "type": "external"
        }
    ],
    "mass": 29608.0,
    "length": 259,
    "protein_name": "Transmembrane O-methyltransferase homolog",
    "gene_name": "tomt",
    "organism": "Zebrafish",
    "refseq_name": "transmembrane O-methyltransferase homolog",
    "refseq_ac": [
        {
            "id": "NP_001411114",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411114",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "tomt; mercury; mrc",
    "gene_names_refseq": "mercury; mrc; tomt",
    "protein_names_uniprotkb": "Transmembrane O-methyltransferase homolog; 2.1.1.6; Protein mercury",
    "protein_names_refseq": "protein mercury; transmembrane O-methyltransferase homolog",
    "tax_id": 7955,
    "disease": "autosomal recessive nonsyndromic deafness 63 (Disease Ontology:DOID:0110515)",
    "pathway": " (dre:110437932);  (R-DRE-379397)",
    "pathway_count": 2,
    "publication_count": 6,
    "publication_id_list": "10526320;23594743;28534737;33376159;36161311;9491988",
    "function": "##Evidence-Data-START## Transcript exon combination :: KX066099.1, SRR32588722.2643588.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476740 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On Sep 8, 2023 this sequence version replaced XP_021322195.1., [RefSeq]; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function. Component of the hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (PubMed:28534737)., [UniProtKB, PubMed, UniProtKB]; The authors found that Tmc1/2 proteins are specifically excluded from the hair bundle in tomt mutants, whereas other mechanotransduction complex proteins can still localize to the bundle. Publication Status: Online-Only, [RefSeq, PubMed]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 1,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "2.1.1.6",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.6",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0016206 catechol O-methyltransferase activity",
    "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016323 basolateral plasma membrane",
    "go_biological_process": "GO:0031223 auditory behavior;GO:0006897 endocytosis;GO:0032502 developmental process;GO:0007605 sensory perception of sound;GO:0042417 dopamine metabolic process",
    "synthesized_glycan_count": 0,
    "hit_score": 0.7,
    "record_id": "A0A193KX02-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000000000000001.00000.000"
}