{
    "uniprot_canonical_ac": "A0A0U1RPR8-1",
    "uniprot_id": [
        {
            "id": "GUC2D_MOUSE",
            "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8",
            "type": "external"
        }
    ],
    "mass": 122528.0,
    "length": 1117,
    "protein_name": "Guanylate cyclase D",
    "gene_name": "Gucy2d",
    "organism": "Mouse",
    "refseq_name": "guanylate cyclase D precursor",
    "refseq_ac": [
        {
            "id": "NP_001124165",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Gucy2d",
    "gene_names_refseq": "Gucy2d",
    "protein_names_uniprotkb": "Guanylate cyclase D; 4.6.1.2",
    "protein_names_refseq": "guanylate cyclase D precursor; guanylate cyclase D; guanylyl cyclase 2d; guanylyl cyclase D; olfactory guanylyl cyclase GC-D",
    "tax_id": 10090,
    "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791)",
    "pathway": " (mmu:14918)",
    "pathway_count": 1,
    "publication_count": 10,
    "publication_id_list": "14993224;17702944;17724338;20637621;21750661;25428506;27881908;32841674;35820727;9096404",
    "function": "Functions as an olfactory receptor activated by urine odorants, uroguanylin and guanylin and as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2) (PubMed:17702944, PubMed:17724338, PubMed:20637621). Has guanylate cyclase activity upon binding of the ligand (By similarity). Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency (PubMed:17724338, PubMed:20637621). Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference (PubMed:20637621)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Mg(2+) binding to GCAPs is critical for setting the actual dynamic range of RetGC regulation by GCAPs at physiological levels of free Ca(2+), [RefSeq, PubMed]; Sensory neurons expressing the atypical olfactory receptor guanylyl cyclase D are required for the acquisition of odor preferences by mice in diverse social contexts., [RefSeq, PubMed]; The S248W mutation contributes to Leber congenital amaurosis 1 by hampering the expression, processing, and/or cellular transport of GUCY2D, rather than its enzymatic properties. Publication Status: Online-Only, [RefSeq, PubMed]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 1,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [
        {
            "id": "4.6.1.2",
            "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding",
    "go_cellular_component": "GO:0060170 ciliary membrane;GO:0016020 membrane",
    "go_biological_process": "GO:0042048 olfactory behavior;GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0007608 sensory perception of smell",
    "synthesized_glycan_count": 0,
    "hit_score": 1.1,
    "record_id": "A0A0U1RPR8-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.010000.0000000000100000.00000.000"
}