{
    "uniprot_canonical_ac": "A0A0R4IXF6-1",
    "uniprot_id": [
        {
            "id": "KAT2A_DANRE",
            "url": "https://www.uniprot.org/uniprot/A0A0R4IXF6",
            "type": "external"
        }
    ],
    "mass": 90624.0,
    "length": 795,
    "protein_name": "Histone acetyltransferase KAT2A",
    "gene_name": "kat2a",
    "organism": "Zebrafish",
    "refseq_name": "",
    "refseq_ac": [],
    "gene_names_uniprotkb": "kat2a",
    "gene_names_refseq": "",
    "protein_names_uniprotkb": "Histone acetyltransferase KAT2A; 2.3.1.-; 2.3.1.48; Histone glutaryltransferase KAT2A; Histone succinyltransferase KAT2A; Lysine acetyltransferase 2A",
    "protein_names_refseq": "",
    "tax_id": 7955,
    "disease": "",
    "pathway": " (dre:555517);  (R-DRE-5250924);  (R-DRE-5689880)",
    "pathway_count": 3,
    "publication_count": 4,
    "publication_id_list": "17997606;23594743;29174768;30424580",
    "function": "Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferasesucc, succinyltransferase or malonyltransferase, depending on the context (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (By similarity). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (By similarity). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (By similarity). Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) (By similarity). Also catalyzes acetylation of histone H1.4 (H1-4) at 'Lys-34' (H1.4K34ac), a modification enriched at promoters of active genes (By similarity). Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Also acetylates non-histone proteins, such as tbx5 (PubMed:29174768). Involved in heart and limb development by mediating acetylation of tbx5 (PubMed:29174768). Together with kat2b, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (PubMed:30424580). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]",
    "predicted_glycosites": 1,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 1,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 1,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 0,
    "glyco_site_count": 1,
    "binding_glycan_count": 0,
    "secondary_ac_list": "A0A0R4IN10;Q1L672",
    "ec_number_list": [
        {
            "id": "2.3.1.48",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
            "type": "external"
        },
        {
            "id": "2.3.1.-",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
            "type": "external"
        },
        {
            "id": "3.6.4.13",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
            "type": "external"
        },
        {
            "id": "2.7.10.2",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
            "type": "external"
        },
        {
            "id": "2.3.1.259",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259",
            "type": "external"
        },
        {
            "id": "3.4.19.12",
            "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
            "type": "external"
        },
        {
            "id": "2.7.7.6",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6",
            "type": "external"
        },
        {
            "id": "2.7.4.3",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
            "type": "external"
        },
        {
            "id": "2.3.1.57",
            "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57",
            "type": "external"
        }
    ],
    "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0106078 histone succinyltransferase activity;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0004402 histone acetyltransferase activity",
    "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0000123 histone acetyltransferase complex;GO:0140672 ATAC complex",
    "go_biological_process": "GO:1903010 regulation of bone development;GO:0006338 chromatin remodeling;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048167 regulation of synaptic plasticity",
    "synthesized_glycan_count": 0,
    "hit_score": 0.5,
    "record_id": "A0A0R4IXF6-1",
    "record_type": "protein",
    "filter_code": "0000000.0000101.100000.0000000000000001.00010.001"
}