{
    "uniprot_canonical_ac": "A0A0R4IXF0-1",
    "uniprot_id": [
        {
            "id": "A0A0R4IXF0_DANRE",
            "url": "https://www.uniprot.org/uniprot/A0A0R4IXF0",
            "type": "external"
        }
    ],
    "mass": 22111.0,
    "length": 192,
    "protein_name": "FAS-associated death domain protein",
    "gene_name": "fadd",
    "organism": "Zebrafish",
    "refseq_name": "FAS-associated death domain protein",
    "refseq_ac": [
        {
            "id": "NP_001373289",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001373289",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "fadd",
    "gene_names_refseq": "fadd",
    "protein_names_uniprotkb": "FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associated death domain protein",
    "protein_names_refseq": "FAS-associated death domain protein",
    "tax_id": 7955,
    "disease": "immunodeficiency 90 (Disease Ontology:DOID:0061060); Alzheimer's disease (Disease Ontology:DOID:10652); leukemia (Disease Ontology:DOID:1240); acute myeloid leukemia (Disease Ontology:DOID:9119)",
    "pathway": " (dre:562317);  (R-DRE-3371378);  (R-DRE-5218900);  (R-DRE-5357786);  (R-DRE-5357905);  (R-DRE-5675482);  (R-DRE-69416);  (R-DRE-75158)",
    "pathway_count": 8,
    "publication_count": 11,
    "publication_id_list": "16888647;17656375;20573960;22357656;23594743;24627485;27356472;27471679;27834691;31492028;33535128",
    "function": "##Evidence-Data-START## Transcript exon combination :: BC114285.1, EE111276.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505375, SAMEA4476736 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Aug 21, 2020 this sequence version replaced XP_001923893.1. Publication Note:  This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling., [UniProtKB, UniProtKB]; Establish that pax2 in combination with vax2 directly regulate the fas-associated death domain (fadd) gene, [RefSeq, PubMed]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 4,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "A0A8M1QLU8",
    "ec_number_list": [],
    "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0089720 caspase binding;GO:0005123 death receptor binding",
    "go_cellular_component": "GO:0005737 cytoplasm;GO:0031265 CD95 death-inducing signaling complex",
    "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0001819 positive regulation of cytokine production;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway;GO:0097191 extrinsic apoptotic signaling pathway",
    "synthesized_glycan_count": 0,
    "hit_score": 1.2,
    "record_id": "A0A0R4IXF0-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000000000000001.00000.000"
}