{
    "uniprot_canonical_ac": "A0A0R4IVC8-1",
    "uniprot_id": [
        {
            "id": "A0A0R4IVC8_DANRE",
            "url": "https://www.uniprot.org/uniprot/A0A0R4IVC8",
            "type": "external"
        }
    ],
    "mass": 15516.0,
    "length": 138,
    "protein_name": "Cytochrome c oxidase subunit 5A, mitochondrial",
    "gene_name": "cox5ab",
    "organism": "Zebrafish",
    "refseq_name": "cytochrome c oxidase subunit 5Ab",
    "refseq_ac": [
        {
            "id": "NP_001292506",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292506",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "cox5ab; Cox5a2; cb01f09; cox5a; mg:cb01f09",
    "gene_names_refseq": "Cox5a2; cb01f09; cox5ab; cox5a; mg:cb01f09",
    "protein_names_uniprotkb": "Cytochrome c oxidase subunit 5A, mitochondrial; Cytochrome c oxidase polypeptide Va",
    "protein_names_refseq": "cytochrome c oxidase subunit 5Ab; cytochrome c oxidase subunit Vab; cytochrome c oxidase subunit Va",
    "tax_id": 7955,
    "disease": "mitochondrial complex IV deficiency nuclear type 20 (Disease Ontology:DOID:0070505)",
    "pathway": " (dre:326962)",
    "pathway_count": 1,
    "publication_count": 11,
    "publication_id_list": "16109975;17761683;20233836;22465854;23594743;27924917;30082823;30428046;32806454;32947675;33482547",
    "function": "##Evidence-Data-START## Transcript exon combination :: EH546885.1, EH577566.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476756 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1, EH546885.1, EH437300.1 and EH483108.1. On Mar 19, 2015 this sequence version replaced XP_700576.1. Publication Note:  This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Analysis of developmental pathology due to cytochrome c oxidase deficiency, [RefSeq, PubMed]; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 1,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "A0A8M1P7E4",
    "ec_number_list": [],
    "go_molecular_function": "GO:0046872 metal ion binding;GO:0004129 cytochrome-c oxidase activity",
    "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV",
    "go_biological_process": "GO:0021522 spinal cord motor neuron differentiation;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0048568 embryonic organ development",
    "synthesized_glycan_count": 0,
    "hit_score": 1.2,
    "record_id": "A0A0R4IVC8-1",
    "record_type": "protein",
    "filter_code": "0000000.0000111.100000.0000000000000001.00000.000"
}