{
    "uniprot_canonical_ac": "A0A0R4IRU6-1",
    "uniprot_id": [
        {
            "id": "A0A0R4IRU6_DANRE",
            "url": "https://www.uniprot.org/uniprot/A0A0R4IRU6",
            "type": "external"
        }
    ],
    "mass": 84176.0,
    "length": 752,
    "protein_name": "Rho GTPase-activating protein 24",
    "gene_name": "arhgap24",
    "organism": "Zebrafish",
    "refseq_name": "rho GTPase-activating protein 24 isoform X1",
    "refseq_ac": [
        {
            "id": "XP_001339010",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001339010",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "arhgap24",
    "gene_names_refseq": "arhgap24",
    "protein_names_uniprotkb": "Rho GTPase-activating protein 24; Rho-type GTPase-activating protein 24",
    "protein_names_refseq": "rho GTPase-activating protein 24 isoform X1",
    "tax_id": 7955,
    "disease": "",
    "pathway": " (dre:100005116);  (R-DRE-8980692);  (R-DRE-9013148);  (R-DRE-9013149)",
    "pathway_count": 4,
    "publication_count": 1,
    "publication_id_list": "23594743",
    "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 9, 2008 this sequence version replaced XP_001339010.1. COMPLETENESS: full length., [RefSeq]; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis., [UniProtKB, UniProtKB]",
    "predicted_glycosites": 0,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 0,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 0,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 0,
    "glyco_site_count": 0,
    "binding_glycan_count": 0,
    "secondary_ac_list": "A0A8M1PUP4",
    "ec_number_list": [],
    "go_molecular_function": "GO:0005096 GTPase activator activity",
    "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005925 focal adhesion;GO:0042995 cell projection",
    "go_biological_process": "GO:0007165 signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction;GO:1900028 negative regulation of ruffle assembly;GO:0030154 cell differentiation;GO:0035313 wound healing, spreading of epidermal cells",
    "synthesized_glycan_count": 0,
    "hit_score": 0.2,
    "record_id": "A0A0R4IRU6-1",
    "record_type": "protein",
    "filter_code": "0000000.0000101.100000.0000000000000001.00000.000"
}