{
    "uniprot_canonical_ac": "A0A0G2KB30-1",
    "uniprot_id": [
        {
            "id": "A0A0G2KB30_RAT",
            "url": "https://www.uniprot.org/uniprot/A0A0G2KB30",
            "type": "external"
        }
    ],
    "mass": 81073.0,
    "length": 739,
    "protein_name": "F-box/LRR-repeat protein 19",
    "gene_name": "Fbxl19",
    "organism": "Rat",
    "refseq_name": "F-box/LRR-repeat protein 19",
    "refseq_ac": [
        {
            "id": "NP_001402857",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001402857",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Fbxl19",
    "gene_names_refseq": "Fbxl19",
    "protein_names_uniprotkb": "F-box/LRR-repeat protein 19; F-box and leucine-rich repeat protein 19",
    "protein_names_refseq": "F-box/LRR-repeat protein 19",
    "tax_id": 10116,
    "disease": "",
    "pathway": " (R-RNO-8951664);  (R-RNO-983168)",
    "pathway_count": 2,
    "publication_count": 0,
    "publication_id_list": "",
    "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization. Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner. Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration. Also mediates ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis. Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation. In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination., [UniProtKB, UniProtKB, UniProtKB]",
    "predicted_glycosites": 1,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 1,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 1,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 0,
    "glyco_site_count": 1,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0032452 histone demethylase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0045322 unmethylated CpG binding",
    "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex",
    "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process",
    "synthesized_glycan_count": 0,
    "hit_score": 0.1,
    "record_id": "A0A0G2KB30-1",
    "record_type": "protein",
    "filter_code": "0000000.0000001.100000.0000000000001000.00010.001"
}