{
    "uniprot_canonical_ac": "A0A0G2JTY4-1",
    "uniprot_id": [
        {
            "id": "NFAC3_RAT",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JTY4",
            "type": "external"
        }
    ],
    "mass": 115656.0,
    "length": 1076,
    "protein_name": "Nuclear factor of activated T-cells, cytoplasmic 3",
    "gene_name": "Nfatc3",
    "organism": "Rat",
    "refseq_name": "nuclear factor of activated T-cells, cytoplasmic 3 isoform 2",
    "refseq_ac": [
        {
            "id": "NP_001421511",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421511",
            "type": "external"
        }
    ],
    "gene_names_uniprotkb": "Nfatc3; Nfat4",
    "gene_names_refseq": "NFAT4; NFATx; Nfatc3",
    "protein_names_uniprotkb": "Nuclear factor of activated T-cells, cytoplasmic 3; NFATc3; NFATx; T-cell transcription factor NFAT4",
    "protein_names_refseq": "T cell transcription factor NFAT4; nuclear factor of activated T-cells, cytoplasmic 3 isoform 2; nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3",
    "tax_id": 10116,
    "disease": "",
    "pathway": " (rno:361400);  (R-RNO-2025928);  (R-RNO-2871809);  (R-RNO-5607763)",
    "pathway_count": 4,
    "publication_count": 8,
    "publication_id_list": "19538478;22673903;30980393;33495839;34845564;36373478;36825443;38242872",
    "function": "Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (PubMed:30980393). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (PubMed:19538478). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (By similarity). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Induction of cardiomyocyte calcification is dependent on FoxO1/NFATc3/Runx2 signaling., [RefSeq, PubMed]; MiR-339-3p promotes AT1-AA-induced vascular inflammation by upregulating NFATc3 protein expression in vascular smooth muscle cells., [RefSeq, PubMed]; MicroRNA153 attenuates hypoxiainduced excessive proliferation and migration of pulmonary arterial smooth muscle cells by targeting ROCK1 and NFATc3. Erratum:[Mol Med Rep. 2022 Nov;26(5):332. doi: 10.3892/mmr.2022.12848. PMID: 36082819], [RefSeq, PubMed]; MicroRNA153 induces apoptosis by targeting NFATc3 to improve vascular remodeling in pulmonary hypertension., [RefSeq, PubMed]; The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3. Publication Status: Online-Only, [RefSeq, PubMed]",
    "predicted_glycosites": 1,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 1,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 1,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 3,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 0,
    "glyco_site_count": 1,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding",
    "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:0005654 nucleoplasm",
    "go_biological_process": "GO:0014904 myotube cell development;GO:0035886 vascular associated smooth muscle cell differentiation;GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation;GO:0007507 heart development;GO:0043065 positive regulation of apoptotic process",
    "synthesized_glycan_count": 0,
    "hit_score": 0.9,
    "record_id": "A0A0G2JTY4-1",
    "record_type": "protein",
    "filter_code": "0000000.0000101.010000.0000000000001000.00011.001"
}