{
    "uniprot_canonical_ac": "A0A061IGN0-1",
    "uniprot_id": [
        {
            "id": "A0A061IGN0_CRIGR",
            "url": "https://www.uniprot.org/uniprot/A0A061IGN0",
            "type": "external"
        }
    ],
    "mass": 74373.0,
    "length": 686,
    "protein_name": "Phosphatidylinositol-binding clathrin assembly protein",
    "gene_name": "Picalm",
    "organism": "Hamster",
    "refseq_name": "",
    "refseq_ac": [],
    "gene_names_uniprotkb": "Picalm; H671_3g9101",
    "gene_names_refseq": "",
    "protein_names_uniprotkb": "Phosphatidylinositol-binding clathrin assembly protein",
    "protein_names_refseq": "",
    "tax_id": 10029,
    "disease": "",
    "pathway": " (cge:100761959)",
    "pathway_count": 1,
    "publication_count": 3,
    "publication_id_list": "23929341;29704459;32410221",
    "function": "Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
    "predicted_glycosites": 1,
    "predicted_n_glycosites": 0,
    "predicted_o_glycosites": 1,
    "mined_glycosites": 0,
    "mined_n_glycosites": 0,
    "mined_o_glycosites": 0,
    "reported_n_glycosites": 0,
    "reported_o_glycosites": 0,
    "reported_n_glycosites_with_glycan": 0,
    "reported_o_glycosites_with_glycan": 0,
    "total_reported_n_glycosites": 0,
    "total_reported_o_glycosites": 0,
    "total_n_glycosites": 0,
    "total_o_glycosites": 1,
    "reported_fully_resolved_glycans": 0,
    "reported_phosphosites": 0,
    "reported_mutagensis": 0,
    "reported_glycation": 0,
    "reported_snv": 0,
    "reported_interactions": 0,
    "missing_score": 10000,
    "biomarker_type": "",
    "glycan_count": 0,
    "disease_count": 0,
    "glyco_site_count": 1,
    "binding_glycan_count": 0,
    "secondary_ac_list": "",
    "ec_number_list": [],
    "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005545 1-phosphatidylinositol binding;GO:0000149 SNARE binding;GO:0032050 clathrin heavy chain binding",
    "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005905 clathrin-coated pit;GO:0030136 clathrin-coated vesicle;GO:0008021 synaptic vesicle",
    "go_biological_process": "GO:0048813 dendrite morphogenesis;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane",
    "synthesized_glycan_count": 0,
    "hit_score": 0.4,
    "record_id": "A0A061IGN0-1",
    "record_type": "protein",
    "filter_code": "0000000.0000101.100000.0000000010000000.00010.001"
}