{
    "glytoucan_ac": "G20577LS",
    "species": [
        {
            "taxid": 9606,
            "name": "Homo sapiens",
            "annotation_category": "direct",
            "evidence": [
                {
                    "database": "GlyConnect",
                    "id": "703",
                    "url": "https://glyconnect.expasy.org/browser/compositions/703"
                },
                {
                    "database": "PubMed",
                    "id": "29741879",
                    "url": "https://glygen.org/publication/PubMed/29741879"
                },
                {
                    "database": "PubMed",
                    "id": "7622940",
                    "url": "https://glygen.org/publication/PubMed/7622940"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mass": 3425.25,
    "classification": [
        {
            "type": {
                "name": "N-linked",
                "url": ""
            },
            "subtype": {
                "name": "Arm-fucosylated"
            }
        },
        {
            "type": {
                "name": "N-linked",
                "url": ""
            },
            "subtype": {
                "name": "Complex",
                "url": ""
            }
        },
        {
            "type": {
                "name": "N-linked",
                "url": ""
            },
            "subtype": {
                "name": "Core-fucosylated"
            }
        },
        {
            "type": {
                "name": "N-linked",
                "url": ""
            },
            "subtype": {
                "name": "Tetraantennary"
            }
        }
    ],
    "composition": [
        {
            "name": "6-Deoxy-Hexose",
            "residue": "dhex",
            "count": 5,
            "cid": "840",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/840"
        },
        {
            "name": "Hexose",
            "residue": "hex",
            "count": 9,
            "cid": "206",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/206"
        },
        {
            "name": "N-Acetylhexosamine",
            "residue": "hexnac",
            "count": 6,
            "cid": "899",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/899"
        },
        {
            "name": "Hexuronic Acid",
            "residue": "hexa",
            "count": 0,
            "cid": "610",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/610"
        },
        {
            "name": "2-Amino-2-Deoxy-Hexose",
            "residue": "hexn",
            "count": 0,
            "cid": "739",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/739"
        },
        {
            "name": "N-Acetyl-Neuraminic Acid",
            "residue": "neuac",
            "count": 0,
            "cid": "439197",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/439197"
        },
        {
            "name": "N-Glycolyl-Neuraminic Acid",
            "residue": "neugc",
            "count": 0,
            "cid": "440001",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/440001"
        },
        {
            "name": "Phosphate",
            "residue": "p",
            "count": 0,
            "cid": "1061",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1061"
        },
        {
            "name": "Pentose",
            "residue": "pent",
            "count": 0,
            "cid": "229",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/229"
        },
        {
            "name": "Sulfate",
            "residue": "s",
            "count": 0,
            "cid": "1117",
            "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1117"
        },
        {
            "name": "Other",
            "residue": "other",
            "count": 0
        }
    ],
    "motifs": [],
    "enzyme": [],
    "biomarkers": [],
    "binding_proteins": [],
    "sites": [
        {
            "start_pos": "553",
            "site_seq": "N",
            "site_lbl": "Asn553",
            "residue": "Asn",
            "glycoprotein": [
                {
                    "uniprot_canonical_ac": "P55011-1",
                    "start_pos": 553,
                    "end_pos": 553,
                    "residue": "Asn",
                    "evidence": [
                        {
                            "database": "PubMed",
                            "id": "29741879",
                            "url": "https://glygen.org/publication/PubMed/29741879"
                        },
                        {
                            "database": "GlyConnect",
                            "id": "1761",
                            "url": "https://glyconnect.expasy.org/browser/proteins/1761"
                        }
                    ],
                    "protein_name": "Solute carrier family 12 member 2",
                    "gene_name": "SLC12A2",
                    "tax_id": 9606,
                    "tax_name": "Homo sapiens",
                    "tax_common_name": "Human",
                    "length": 1212,
                    "chemical_mass": 131447.0
                }
            ]
        },
        {
            "start_pos": "553",
            "site_seq": "DATGNVNDTIVTELTNCTSAACK",
            "site_lbl": "Asn553",
            "residue": "Asn",
            "glycoprotein": [
                {
                    "uniprot_canonical_ac": "P55011-1",
                    "start_pos": 553,
                    "end_pos": 553,
                    "residue": "Asn",
                    "evidence": [
                        {
                            "database": "PubMed",
                            "id": "29741879",
                            "url": "https://glygen.org/publication/PubMed/29741879"
                        },
                        {
                            "database": "GlyConnect",
                            "id": "1761",
                            "url": "https://glyconnect.expasy.org/browser/proteins/1761"
                        }
                    ],
                    "protein_name": "Solute carrier family 12 member 2",
                    "gene_name": "SLC12A2",
                    "tax_id": 9606,
                    "tax_name": "Homo sapiens",
                    "tax_common_name": "Human",
                    "length": 1212,
                    "chemical_mass": 131447.0
                }
            ]
        },
        {
            "start_pos": "553",
            "site_seq": "",
            "site_lbl": "N553",
            "residue": "",
            "snv": [
                {
                    "weight": 100,
                    "sequence_org": "N",
                    "sequence_mut": "D",
                    "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NDT->DDT).",
                    "chr_id": "5",
                    "chr_pos": "128141865",
                    "evidence": [
                        {
                            "id": "P55011",
                            "database": "BioMuta",
                            "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/P55011"
                        }
                    ],
                    "disease": [
                        {
                            "disease_id": "DOID:9256",
                            "name": "colorectal cancer",
                            "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum.",
                            "url": "http://disease-ontology.org/term/DOID:9256",
                            "evidence": [
                                {
                                    "id": "9256",
                                    "database": "AGR",
                                    "url": "https://www.alliancegenome.org/disease/DOID:9256"
                                }
                            ]
                        }
                    ]
                },
                {
                    "weight": 100,
                    "sequence_org": "N",
                    "sequence_mut": "I",
                    "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NDT->IDT).",
                    "chr_id": "5",
                    "chr_pos": "128141866",
                    "evidence": [
                        {
                            "id": "rs1439476038",
                            "database": "dbSNP",
                            "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1439476038"
                        },
                        {
                            "id": "rs1439476038",
                            "database": "gnomAD",
                            "url": "http://gnomad.broadinstitute.org/awesome?query=rs1439476038"
                        }
                    ]
                }
            ],
            "glycoprotein": [
                {
                    "uniprot_canonical_ac": "P55011-1",
                    "start_pos": 553,
                    "end_pos": 553,
                    "residue": "Asn",
                    "evidence": [
                        {
                            "database": "PubMed",
                            "id": "29741879",
                            "url": "https://glygen.org/publication/PubMed/29741879"
                        },
                        {
                            "database": "GlyConnect",
                            "id": "1761",
                            "url": "https://glyconnect.expasy.org/browser/proteins/1761"
                        }
                    ],
                    "protein_name": "Solute carrier family 12 member 2",
                    "gene_name": "SLC12A2",
                    "tax_id": 9606,
                    "tax_name": "Homo sapiens",
                    "tax_common_name": "Human",
                    "length": 1212,
                    "chemical_mass": 131447.0
                }
            ]
        },
        {
            "start_pos": "914",
            "site_seq": "N",
            "site_lbl": "Asn914",
            "residue": "Asn",
            "glycoprotein": [
                {
                    "uniprot_canonical_ac": "O75882-1",
                    "start_pos": 914,
                    "end_pos": 914,
                    "residue": "Asn",
                    "evidence": [
                        {
                            "database": "PubMed",
                            "id": "29741879",
                            "url": "https://glygen.org/publication/PubMed/29741879"
                        },
                        {
                            "database": "GlyConnect",
                            "id": "679",
                            "url": "https://glyconnect.expasy.org/browser/proteins/679"
                        }
                    ],
                    "protein_name": "Attractin",
                    "gene_name": "ATRN",
                    "tax_id": 9606,
                    "tax_name": "Homo sapiens",
                    "tax_common_name": "Human",
                    "length": 1429,
                    "chemical_mass": 158537.0
                }
            ]
        },
        {
            "start_pos": "914",
            "site_seq": "AATCINPLnGSVCERPANHSAK",
            "site_lbl": "Asn914",
            "residue": "Asn",
            "glycoprotein": [
                {
                    "uniprot_canonical_ac": "O75882-1",
                    "start_pos": 914,
                    "end_pos": 914,
                    "residue": "Asn",
                    "evidence": [
                        {
                            "database": "PubMed",
                            "id": "29741879",
                            "url": "https://glygen.org/publication/PubMed/29741879"
                        },
                        {
                            "database": "GlyConnect",
                            "id": "679",
                            "url": "https://glyconnect.expasy.org/browser/proteins/679"
                        }
                    ],
                    "protein_name": "Attractin",
                    "gene_name": "ATRN",
                    "tax_id": 9606,
                    "tax_name": "Homo sapiens",
                    "tax_common_name": "Human",
                    "length": 1429,
                    "chemical_mass": 158537.0
                }
            ]
        },
        {
            "start_pos": "914",
            "site_seq": "AATCINPLNGSVCERPANHSAK",
            "site_lbl": "Asn914",
            "residue": "Asn",
            "glycoprotein": [
                {
                    "uniprot_canonical_ac": "O75882-1",
                    "start_pos": 914,
                    "end_pos": 914,
                    "residue": "Asn",
                    "evidence": [
                        {
                            "database": "PubMed",
                            "id": "29741879",
                            "url": "https://glygen.org/publication/PubMed/29741879"
                        },
                        {
                            "database": "GlyConnect",
                            "id": "679",
                            "url": "https://glyconnect.expasy.org/browser/proteins/679"
                        }
                    ],
                    "protein_name": "Attractin",
                    "gene_name": "ATRN",
                    "tax_id": 9606,
                    "tax_name": "Homo sapiens",
                    "tax_common_name": "Human",
                    "length": 1429,
                    "chemical_mass": 158537.0
                }
            ]
        },
        {
            "start_pos": "914",
            "site_seq": "",
            "site_lbl": "N914",
            "residue": "",
            "snv": [
                {
                    "weight": 100,
                    "sequence_org": "N",
                    "sequence_mut": "S",
                    "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NGS->SGS).",
                    "chr_id": "20",
                    "chr_pos": "3582331",
                    "evidence": [
                        {
                            "id": "rs770889604",
                            "database": "dbSNP",
                            "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs770889604"
                        },
                        {
                            "id": "rs770889604",
                            "database": "ExAC",
                            "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs770889604"
                        },
                        {
                            "id": "rs770889604",
                            "database": "gnomAD",
                            "url": "http://gnomad.broadinstitute.org/awesome?query=rs770889604"
                        }
                    ]
                }
            ],
            "glycoprotein": [
                {
                    "uniprot_canonical_ac": "O75882-1",
                    "start_pos": 914,
                    "end_pos": 914,
                    "residue": "Asn",
                    "evidence": [
                        {
                            "database": "PubMed",
                            "id": "29741879",
                            "url": "https://glygen.org/publication/PubMed/29741879"
                        },
                        {
                            "database": "GlyConnect",
                            "id": "679",
                            "url": "https://glyconnect.expasy.org/browser/proteins/679"
                        }
                    ],
                    "protein_name": "Attractin",
                    "gene_name": "ATRN",
                    "tax_id": 9606,
                    "tax_name": "Homo sapiens",
                    "tax_common_name": "Human",
                    "length": 1429,
                    "chemical_mass": 158537.0
                }
            ]
        },
        {
            "start_pos": "111",
            "site_seq": "YPHNHHVVnNTLEGNCSSK",
            "site_lbl": "Asn111",
            "residue": "Asn",
            "glycoprotein": [
                {
                    "uniprot_canonical_ac": "P15586-1",
                    "start_pos": 111,
                    "end_pos": 111,
                    "residue": "Asn",
                    "evidence": [
                        {
                            "database": "PubMed",
                            "id": "29741879",
                            "url": "https://glygen.org/publication/PubMed/29741879"
                        },
                        {
                            "database": "GlyConnect",
                            "id": "796",
                            "url": "https://glyconnect.expasy.org/browser/proteins/796"
                        }
                    ],
                    "protein_name": "N-acetylglucosamine-6-sulfatase",
                    "gene_name": "GNS",
                    "tax_id": 9606,
                    "tax_name": "Homo sapiens",
                    "tax_common_name": "Human",
                    "length": 552,
                    "chemical_mass": 62082.0
                }
            ]
        },
        {
            "start_pos": "111",
            "site_seq": "N",
            "site_lbl": "Asn111",
            "residue": "Asn",
            "glycoprotein": [
                {
                    "uniprot_canonical_ac": "P15586-1",
                    "start_pos": 111,
                    "end_pos": 111,
                    "residue": "Asn",
                    "evidence": [
                        {
                            "database": "PubMed",
                            "id": "29741879",
                            "url": "https://glygen.org/publication/PubMed/29741879"
                        },
                        {
                            "database": "GlyConnect",
                            "id": "796",
                            "url": "https://glyconnect.expasy.org/browser/proteins/796"
                        }
                    ],
                    "protein_name": "N-acetylglucosamine-6-sulfatase",
                    "gene_name": "GNS",
                    "tax_id": 9606,
                    "tax_name": "Homo sapiens",
                    "tax_common_name": "Human",
                    "length": 552,
                    "chemical_mass": 62082.0
                }
            ]
        },
        {
            "start_pos": "111",
            "site_seq": "YPHNHHVVNNTLEGNCSSK",
            "site_lbl": "Asn111",
            "residue": "Asn",
            "glycoprotein": [
                {
                    "uniprot_canonical_ac": "P15586-1",
                    "start_pos": 111,
                    "end_pos": 111,
                    "residue": "Asn",
                    "evidence": [
                        {
                            "database": "PubMed",
                            "id": "29741879",
                            "url": "https://glygen.org/publication/PubMed/29741879"
                        },
                        {
                            "database": "GlyConnect",
                            "id": "796",
                            "url": "https://glyconnect.expasy.org/browser/proteins/796"
                        }
                    ],
                    "protein_name": "N-acetylglucosamine-6-sulfatase",
                    "gene_name": "GNS",
                    "tax_id": 9606,
                    "tax_name": "Homo sapiens",
                    "tax_common_name": "Human",
                    "length": 552,
                    "chemical_mass": 62082.0
                }
            ]
        },
        {
            "start_pos": "111",
            "site_seq": "",
            "site_lbl": "N111",
            "residue": "",
            "snv": [
                {
                    "weight": 100,
                    "sequence_org": "N",
                    "sequence_mut": "K",
                    "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NNT->KNT).",
                    "chr_id": "12",
                    "chr_pos": "64747838",
                    "evidence": [
                        {
                            "id": "P15586",
                            "database": "BioMuta",
                            "url": "https://hivelab.biochemistry.gwu.edu/biomuta/proteinview/P15586"
                        },
                        {
                            "id": "rs1199190795",
                            "database": "dbSNP",
                            "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1199190795"
                        },
                        {
                            "id": "rs1199190795",
                            "database": "TOPMed",
                            "url": "https://www.ncbi.nlm.nih.gov/snp/rs1199190795#frequency_tab"
                        },
                        {
                            "id": "rs1199190795",
                            "database": "gnomAD",
                            "url": "http://gnomad.broadinstitute.org/awesome?query=rs1199190795"
                        },
                        {
                            "id": "rs1199190795",
                            "database": "COSMIC",
                            "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs1199190795"
                        }
                    ],
                    "disease": [
                        {
                            "disease_id": "DOID:10534",
                            "name": "stomach cancer",
                            "description": "A gastrointestinal system cancer that is located_in the stomach.",
                            "url": "http://disease-ontology.org/term/DOID:10534",
                            "evidence": [
                                {
                                    "id": "10534",
                                    "database": "AGR",
                                    "url": "https://www.alliancegenome.org/disease/DOID:10534"
                                },
                                {
                                    "id": "10534",
                                    "database": "AGR",
                                    "url": "https://www.alliancegenome.org/disease/DOID:10534"
                                }
                            ]
                        },
                        {
                            "disease_id": "DOID:0111402",
                            "name": "mucopolysaccharidosis type IIID",
                            "description": "A mucopolysaccharidosis III that has_material_basis_in homozygous or compound heterozygous mutation in GNS on chromosome 12q14.3.",
                            "url": "http://disease-ontology.org/term/DOID:0111402",
                            "evidence": [
                                {
                                    "id": "0009658",
                                    "database": "MONDO",
                                    "url": "https://monarchinitiative.org/disease/MONDO:0009658"
                                },
                                {
                                    "id": "252940",
                                    "database": "MIM",
                                    "url": "https://www.omim.org/entry/252940"
                                },
                                {
                                    "id": "2799",
                                    "database": "GlyCosmos",
                                    "url": "https://glycosmos.org/glycogenes/show/2799#disease"
                                },
                                {
                                    "id": "0111402",
                                    "database": "AGR",
                                    "url": "https://www.alliancegenome.org/disease/DOID:0111402"
                                }
                            ]
                        },
                        {
                            "disease_id": "DOID:0111402",
                            "name": "mucopolysaccharidosis type IIID",
                            "description": "A mucopolysaccharidosis III that has_material_basis_in homozygous or compound heterozygous mutation in GNS on chromosome 12q14.3.",
                            "url": "http://disease-ontology.org/term/DOID:0111402",
                            "evidence": [
                                {
                                    "id": "0009658",
                                    "database": "MONDO",
                                    "url": "https://monarchinitiative.org/disease/MONDO:0009658"
                                },
                                {
                                    "id": "252940",
                                    "database": "MIM",
                                    "url": "https://www.omim.org/entry/252940"
                                },
                                {
                                    "id": "2799",
                                    "database": "GlyCosmos",
                                    "url": "https://glycosmos.org/glycogenes/show/2799#disease"
                                },
                                {
                                    "id": "0111402",
                                    "database": "AGR",
                                    "url": "https://www.alliancegenome.org/disease/DOID:0111402"
                                }
                            ]
                        },
                        {
                            "disease_id": "DOID:0111402",
                            "name": "mucopolysaccharidosis type IIID",
                            "description": "A mucopolysaccharidosis III that has_material_basis_in homozygous or compound heterozygous mutation in GNS on chromosome 12q14.3.",
                            "url": "http://disease-ontology.org/term/DOID:0111402",
                            "evidence": [
                                {
                                    "id": "0009658",
                                    "database": "MONDO",
                                    "url": "https://monarchinitiative.org/disease/MONDO:0009658"
                                },
                                {
                                    "id": "252940",
                                    "database": "MIM",
                                    "url": "https://www.omim.org/entry/252940"
                                },
                                {
                                    "id": "2799",
                                    "database": "GlyCosmos",
                                    "url": "https://glycosmos.org/glycogenes/show/2799#disease"
                                },
                                {
                                    "id": "0111402",
                                    "database": "AGR",
                                    "url": "https://www.alliancegenome.org/disease/DOID:0111402"
                                }
                            ]
                        }
                    ]
                }
            ],
            "glycoprotein": [
                {
                    "uniprot_canonical_ac": "P15586-1",
                    "start_pos": 111,
                    "end_pos": 111,
                    "residue": "Asn",
                    "evidence": [
                        {
                            "database": "PubMed",
                            "id": "29741879",
                            "url": "https://glygen.org/publication/PubMed/29741879"
                        },
                        {
                            "database": "GlyConnect",
                            "id": "796",
                            "url": "https://glyconnect.expasy.org/browser/proteins/796"
                        }
                    ],
                    "protein_name": "N-acetylglucosamine-6-sulfatase",
                    "gene_name": "GNS",
                    "tax_id": 9606,
                    "tax_name": "Homo sapiens",
                    "tax_common_name": "Human",
                    "length": 552,
                    "chemical_mass": 62082.0
                }
            ]
        }
    ],
    "record_id": "G20577LS"
}