{ "glytoucan_ac": "G08539HC", "species": [ { "taxid": 9606, "name": "Homo sapiens", "annotation_category": "direct", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000888", "url": "https://data.glygen.org/GLY_000888" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" }, { "taxid": 10090, "name": "Mus musculus", "annotation_category": "direct", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "mass": 2849.04, "classification": [ { "type": { "name": "N-linked", "url": "" }, "subtype": { "name": "Arm-fucosylated" } }, { "type": { "name": "N-linked", "url": "" }, "subtype": { "name": "Bisected" } }, { "type": { "name": "N-linked", "url": "" }, "subtype": { "name": "Complex", "url": "" } }, { "type": { "name": "N-linked", "url": "" }, "subtype": { "name": "Core-fucosylated" } }, { "type": { "name": "N-linked", "url": "" }, "subtype": { "name": "Tetraantennary" } } ], "composition": [ { "name": "6-Deoxy-Hexose", "residue": "dhex", "count": 1, "cid": "840", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/840" }, { "name": "Hexose", "residue": "hex", "count": 6, "cid": "206", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/206" }, { "name": "N-Acetylhexosamine", "residue": "hexnac", "count": 7, "cid": "899", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/899" }, { "name": "Hexuronic Acid", "residue": "hexa", "count": 0, "cid": "610", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/610" }, { "name": "2-Amino-2-Deoxy-Hexose", "residue": "hexn", "count": 0, "cid": "739", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/739" }, { "name": "N-Acetyl-Neuraminic Acid", "residue": "neuac", "count": 1, "cid": "439197", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/439197" }, { "name": "N-Glycolyl-Neuraminic Acid", "residue": "neugc", "count": 0, "cid": "440001", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/440001" }, { "name": "Phosphate", "residue": "p", "count": 0, "cid": "1061", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1061" }, { "name": "Pentose", "residue": "pent", "count": 0, "cid": "229", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/229" }, { "name": "Sulfate", "residue": "s", "count": 0, "cid": "1117", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/1117" }, { "name": "Other", "residue": "other", "count": 0 } ], "motifs": [], "enzyme": [], "biomarkers": [], "binding_proteins": [], "sites": [ { "start_pos": "279", "site_seq": "N", "site_lbl": "Asn279", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "Q6YHK3-1", "start_pos": 279, "end_pos": 279, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "Data Submission", "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888" } ], "protein_name": "CD109 antigen", "gene_name": "CD109", "tax_id": 9606, "tax_name": "Homo sapiens", "tax_common_name": "Human", "length": 1445, "chemical_mass": 161689.0 } ] }, { "start_pos": "279", "site_seq": "NITKTFKINGSANFSFNDEEMK", "site_lbl": "Asn279", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "Q6YHK3-1", "start_pos": 279, "end_pos": 279, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "Data Submission", "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888" } ], "protein_name": "CD109 antigen", "gene_name": "CD109", "tax_id": 9606, "tax_name": "Homo sapiens", "tax_common_name": "Human", "length": 1445, "chemical_mass": 161689.0 } ] }, { "start_pos": "279", "site_seq": "", "site_lbl": "N279", "residue": "", "snv": [ { "weight": 100, "sequence_org": "N", "sequence_mut": "H", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NIT->HIT).", "chr_id": "6", "chr_pos": "73762460", "evidence": [ { "id": "rs1773672744", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1773672744" }, { "id": "rs1773672744", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1773672744#frequency_tab" } ] } ], "glycoprotein": [ { "uniprot_canonical_ac": "Q6YHK3-1", "start_pos": 279, "end_pos": 279, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "Data Submission", "id": "GLY_000888", "url": "http://data.glygen.org/GLY_000888" } ], "protein_name": "CD109 antigen", "gene_name": "CD109", "tax_id": 9606, "tax_name": "Homo sapiens", "tax_common_name": "Human", "length": 1445, "chemical_mass": 161689.0 } ] }, { "start_pos": "1047", "site_seq": "N", "site_lbl": "Asn1047", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "Q810U3-1", "start_pos": 1047, "end_pos": 1047, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Neurofascin", "gene_name": "Nfasc", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 1240, "chemical_mass": 137975.0 } ] }, { "start_pos": "1047", "site_seq": "PGTDFVVEYIDSNHTK", "site_lbl": "Asn1047", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "Q810U3-1", "start_pos": 1047, "end_pos": 1047, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Neurofascin", "gene_name": "Nfasc", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 1240, "chemical_mass": 137975.0 } ] }, { "start_pos": "262", "site_seq": "SNYSVIDLTPVAAILPK", "site_lbl": "Asn262", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "Q8BTJ4-1", "start_pos": 262, "end_pos": 262, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Bis(5'-adenosyl)-triphosphatase enpp4", "gene_name": "Enpp4", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 456, "chemical_mass": 51611.0 } ] }, { "start_pos": "1021", "site_seq": "NTSLSSSAIYTDLAPFK", "site_lbl": "Asn1021", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "Q0V8T9-1", "start_pos": 1021, "end_pos": 1021, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Contactin-associated protein like 5-1", "gene_name": "Cntnap5a", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 1304, "chemical_mass": 145711.0 } ] }, { "start_pos": "278", "site_seq": "TKVPSGIEEGTVPDNTSSTSGK", "site_lbl": "Asn278", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "Q9EPU5-1", "start_pos": 278, "end_pos": 278, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Tumor necrosis factor receptor superfamily member 21", "gene_name": "Tnfrsf21", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 655, "chemical_mass": 71983.0 } ] }, { "start_pos": "278", "site_seq": "N", "site_lbl": "Asn278", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "Q9EPU5-1", "start_pos": 278, "end_pos": 278, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Tumor necrosis factor receptor superfamily member 21", "gene_name": "Tnfrsf21", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 655, "chemical_mass": 71983.0 } ] }, { "start_pos": "389", "site_seq": "AGFEYAFDQLQNSNITR", "site_lbl": "Asn389", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "Q6PHS9-1", "start_pos": 389, "end_pos": 389, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-2", "gene_name": "Cacna2d2", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 1154, "chemical_mass": 130385.0 } ] }, { "start_pos": "389", "site_seq": "N", "site_lbl": "Asn389", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "Q6PHS9-1", "start_pos": 389, "end_pos": 389, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-2", "gene_name": "Cacna2d2", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 1154, "chemical_mass": 130385.0 } ] }, { "start_pos": "153", "site_seq": "WEGELGTDLVSIPHGPNVTVR", "site_lbl": "Asn153", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "P56818-1", "start_pos": 153, "end_pos": 153, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Beta-secretase 1", "gene_name": "Bace1", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 501, "chemical_mass": 55748.0 } ] }, { "start_pos": "153", "site_seq": "N", "site_lbl": "Asn153", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "P56818-1", "start_pos": 153, "end_pos": 153, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Beta-secretase 1", "gene_name": "Bace1", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 501, "chemical_mass": 55748.0 } ] }, { "start_pos": "153", "site_seq": "", "site_lbl": "N153", "residue": "", "snv": [ { "weight": 100, "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVT->DVT).", "chr_id": "9", "chr_pos": "45766031", "evidence": [ { "id": "rs3389015629", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389015629" } ] } ], "glycoprotein": [ { "uniprot_canonical_ac": "P56818-1", "start_pos": 153, "end_pos": 153, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Beta-secretase 1", "gene_name": "Bace1", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 501, "chemical_mass": 55748.0 } ] }, { "start_pos": "153", "site_seq": "", "site_lbl": "", "residue": "", "mutagenesis": [ { "weight": 100, "sequence_org": "N", "sequence_mut": "S", "comment": "Decreases bisecting N-acetylglucosamine levels. Almost abolishes bisecting N-acetylglucosamine levels but has no effect on surface expression; when associated with S-223.", "evidence": [ { "database": "UniProtKB", "id": "P56818", "url": "https://www.uniprot.org/uniprotkb/P56818" }, { "database": "PubMed", "id": "26467158", "url": "https://glygen.org/publication/PubMed/26467158" } ] } ], "glycoprotein": [ { "uniprot_canonical_ac": "P56818-1", "start_pos": 153, "end_pos": 153, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Beta-secretase 1", "gene_name": "Bace1", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 501, "chemical_mass": 55748.0 } ] }, { "start_pos": "67", "site_seq": "VYSGVVSLSTENIYSFNHTSHPGQVTAVR", "site_lbl": "Asn67", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "Q6AXF6-1", "start_pos": 67, "end_pos": 67, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "SID1 transmembrane family member 1", "gene_name": "Sidt1", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 827, "chemical_mass": 93896.0 } ] }, { "start_pos": "67", "site_seq": "N", "site_lbl": "Asn67", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "Q6AXF6-1", "start_pos": 67, "end_pos": 67, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "SID1 transmembrane family member 1", "gene_name": "Sidt1", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 827, "chemical_mass": 93896.0 } ] }, { "start_pos": "347", "site_seq": "DNFTLIPEGTNGTEER", "site_lbl": "Asn347", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "O08553-1", "start_pos": 347, "end_pos": 347, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Dihydropyrimidinase-related protein 2", "gene_name": "Dpysl2", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 572, "chemical_mass": 62278.0 } ] }, { "start_pos": "347", "site_seq": "", "site_lbl": "N347", "residue": "", "snv": [ { "weight": 100, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NFT->SFT).", "chr_id": "14", "chr_pos": "67052474", "evidence": [ { "id": "rs3389337017", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389337017" } ] } ], "glycoprotein": [ { "uniprot_canonical_ac": "O08553-1", "start_pos": 347, "end_pos": 347, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Dihydropyrimidinase-related protein 2", "gene_name": "Dpysl2", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 572, "chemical_mass": 62278.0 } ] }, { "start_pos": "348", "site_seq": "NISSEEKTLDGHMVVR", "site_lbl": "Asn348", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "P13595-1", "start_pos": 348, "end_pos": 348, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Neural cell adhesion molecule 1", "gene_name": "Ncam1", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 1115, "chemical_mass": 119427.0 } ] }, { "start_pos": "348", "site_seq": "NISSEEK", "site_lbl": "Asn348", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "P13595-1", "start_pos": 348, "end_pos": 348, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Neural cell adhesion molecule 1", "gene_name": "Ncam1", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 1115, "chemical_mass": 119427.0 } ] }, { "start_pos": "348", "site_seq": "N", "site_lbl": "Asn348", "residue": "Asn", "glycoprotein": [ { "uniprot_canonical_ac": "P13595-1", "start_pos": 348, "end_pos": 348, "residue": "Asn", "evidence": [ { "database": "DOI", "id": "10.1101/2023.09.13.557529", "url": "https://glygen.org/publication/DOI/10.1101/2023.09.13.557529" }, { "database": "GlyGen", "id": "GLY_000889", "url": "https://data.glygen.org/GLY_000889" } ], "protein_name": "Neural cell adhesion molecule 1", "gene_name": "Ncam1", "tax_id": 10090, "tax_name": "Mus musculus", "tax_common_name": "Mouse", "length": 1115, "chemical_mass": 119427.0 } ] } ], "record_id": "G08539HC" }