{
    "title": "ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.",
    "journal": "Genes &amp; development",
    "date": "1999",
    "authors": "Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway CA, Ghosh S",
    "reference": {
        "type": "PubMed",
        "id": "10465784",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10465784"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q9Y4K3-1",
            "protein_name": "TNF receptor-associated factor 6",
            "gene_name": "TRAF6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P02671-1",
            "protein_name": "Fibrinogen alpha chain",
            "gene_name": "FGA",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00206-1",
            "protein_name": "Toll-like receptor 4",
            "gene_name": "TLR4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O15524-1",
            "protein_name": "Suppressor of cytokine signaling 1",
            "gene_name": "SOCS1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P09429-1",
            "protein_name": "High mobility group protein B1",
            "gene_name": "HMGB1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q06187-1",
            "protein_name": "Tyrosine-protein kinase BTK",
            "gene_name": "BTK",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q6IA17-1",
            "protein_name": "Single Ig IL-1-related receptor",
            "gene_name": "SIGIRR",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P05109-1",
            "protein_name": "Protein S100-A8",
            "gene_name": "S100A8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P06702-1",
            "protein_name": "Protein S100-A9",
            "gene_name": "S100A9",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99836-1",
            "protein_name": "Myeloid differentiation primary response protein MyD88",
            "gene_name": "MYD88",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P23297-1",
            "protein_name": "Protein S100-A1",
            "gene_name": "S100A1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P02675-1",
            "protein_name": "Fibrinogen beta chain",
            "gene_name": "FGB",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9NWZ3-1",
            "protein_name": "Interleukin-1 receptor-associated kinase 4",
            "gene_name": "IRAK4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9QZH6-1",
            "protein_name": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial",
            "gene_name": "Ecsit",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "P02679-1",
            "protein_name": "Fibrinogen gamma chain",
            "gene_name": "FGG",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O60603-1",
            "protein_name": "Toll-like receptor 2",
            "gene_name": "TLR2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P58753-1",
            "protein_name": "Toll/interleukin-1 receptor domain-containing adapter protein",
            "gene_name": "TIRAP",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O43187-1",
            "protein_name": "Interleukin-1 receptor-associated kinase-like 2",
            "gene_name": "IRAK2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P08571-1",
            "protein_name": "Monocyte differentiation antigen CD14",
            "gene_name": "CD14",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9BQ95-1",
            "protein_name": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial",
            "gene_name": "ECSIT",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y2C9-1",
            "protein_name": "Toll-like receptor 6",
            "gene_name": "TLR6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13233-1",
            "protein_name": "Mitogen-activated protein kinase kinase kinase 1",
            "gene_name": "MAP3K1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P51617-1",
            "protein_name": "Interleukin-1 receptor-associated kinase 1",
            "gene_name": "IRAK1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P16671-1",
            "protein_name": "Platelet glycoprotein 4",
            "gene_name": "CD36",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q15399-1",
            "protein_name": "Toll-like receptor 1",
            "gene_name": "TLR1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y616-1",
            "protein_name": "Interleukin-1 receptor-associated kinase 3",
            "gene_name": "IRAK3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y6Y9-1",
            "protein_name": "Lymphocyte antigen 96",
            "gene_name": "LY96",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9U6M0-1",
            "protein_name": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial",
            "gene_name": "ECSIT",
            "tax_name": "Fruit fly"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Y4K3",
                    "url": "https://www.uniprot.org/uniprotkb/Q9Y4K3"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "record_id": "pubmed.10465784",
    "abstract": "",
    "glycosylation": [],
    "mutagenesis": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 28
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}
