{
    "title": "Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.",
    "journal": "J. Biol. Chem.",
    "date": "1999",
    "authors": "Oppermann M, Mack M, Proudfoot AE, Olbrich H",
    "reference": {
        "type": "PubMed",
        "id": "10085131",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10085131"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P25098-1",
            "protein_name": "Beta-adrenergic receptor kinase 1",
            "gene_name": "GRK2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P51681-1",
            "protein_name": "C-C chemokine receptor type 5",
            "gene_name": "CCR5",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P25098",
                    "url": "https://www.uniprot.org/uniprotkb/P25098"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 336,
            "end_pos": 336,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "APO-RANTES-stimulated phosphorylation reduced by 15%; APO-RANTES-stimulated phosphorylation reduced by 30-50%; when associated with A-337 or A-342 or A-349; APO-RANTES-stimulated phosphorylation reduced by 80%; when associated with A-337 and A-342 or A-349; No APO-RANTES-stimulated phosphorylation; when associated with A-337; A-342 and A349; abolishes interaction with ARRB2; when associated with S-337; S-342 and S-349.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51681",
                    "url": "https://www.uniprot.org/uniprotkb/P51681"
                },
                {
                    "database": "PubMed",
                    "id": "10085131",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10085131"
                },
                {
                    "database": "PubMed",
                    "id": "11448957",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11448957"
                }
            ],
            "uniprot_canonical_ac": "P51681-1"
        },
        {
            "start_pos": 337,
            "end_pos": 337,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "APO-RANTES-stimulated phosphorylation reduced by 18%; APO-RANTES-stimulated phosphorylation reduced by 30-50% on APO-RANTES stimulation; when associated with A-336 or A-342 or A-349; APO-RANTES-stimulated phosphorylation reduced by 80%; when associated with A-336 and A-342 or A-349; No APO-RANTES-stimulated phosphorylation; when associated with A-336; A-342 and A349; abolishes interaction with ARRB2; when associated with S-336; S-342 and S-349.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51681",
                    "url": "https://www.uniprot.org/uniprotkb/P51681"
                },
                {
                    "database": "PubMed",
                    "id": "10085131",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10085131"
                },
                {
                    "database": "PubMed",
                    "id": "11448957",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11448957"
                }
            ],
            "uniprot_canonical_ac": "P51681-1"
        },
        {
            "start_pos": 342,
            "end_pos": 342,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "APO-RANTES-stimulated phosphorylation reduced by 42%. Phosphorylation reduced by 50% on APO-RANTES stimulation; when associated with A-336 or A-337 or A-349; APO-RANTES-stimulated phosphorylation reduced by 80% when associated with A-336 and A-337 or A-349; No APO-RANTES-stimulated phosphorylation; when associated with A-336; A-337 and A349; abolishes interaction with ARRB2; when associated with S-336; S-337 and S-349.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51681",
                    "url": "https://www.uniprot.org/uniprotkb/P51681"
                },
                {
                    "database": "PubMed",
                    "id": "10085131",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10085131"
                },
                {
                    "database": "PubMed",
                    "id": "11448957",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11448957"
                }
            ],
            "uniprot_canonical_ac": "P51681-1"
        },
        {
            "start_pos": 349,
            "end_pos": 349,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "APO-RANTES-stimulated phosphorylation reduced by 43%; APO-RANTES-stimulated phosphorylation reduced by 30-50%; when associated with A-336 or A-337 or A-342; APO-RANTES-stimulated phosphorylation reduced by 80%; when associated with A-336 and A-337 or A-342; No APO-RANTES-stimulated phosphorylation stimulation; when associated with A-336; A-337 and A347; abolishes interaction with ARRB2; when associated with S-336; S-337 and S-342.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51681",
                    "url": "https://www.uniprot.org/uniprotkb/P51681"
                },
                {
                    "database": "PubMed",
                    "id": "10085131",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10085131"
                },
                {
                    "database": "PubMed",
                    "id": "11448957",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11448957"
                }
            ],
            "uniprot_canonical_ac": "P51681-1"
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 336,
            "end_pos": 336,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine; by BARK1",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51681",
                    "url": "https://www.uniprot.org/uniprotkb/P51681"
                },
                {
                    "database": "iPTMnet",
                    "id": "P51681",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P51681"
                },
                {
                    "database": "PubMed",
                    "id": "10085131",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10085131"
                }
            ],
            "site_lbl": "Ser336",
            "uniprot_canonical_ac": "P51681-1"
        },
        {
            "start_pos": 337,
            "end_pos": 337,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine; by BARK1",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51681",
                    "url": "https://www.uniprot.org/uniprotkb/P51681"
                },
                {
                    "database": "iPTMnet",
                    "id": "P51681",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P51681"
                },
                {
                    "database": "PubMed",
                    "id": "10085131",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10085131"
                },
                {
                    "database": "PubMed",
                    "id": "12403770",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/12403770"
                }
            ],
            "site_lbl": "Ser337",
            "uniprot_canonical_ac": "P51681-1"
        },
        {
            "start_pos": 342,
            "end_pos": 342,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine; by BARK1",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51681",
                    "url": "https://www.uniprot.org/uniprotkb/P51681"
                },
                {
                    "database": "iPTMnet",
                    "id": "P51681",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P51681"
                },
                {
                    "database": "PubMed",
                    "id": "10085131",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10085131"
                }
            ],
            "site_lbl": "Ser342",
            "uniprot_canonical_ac": "P51681-1"
        },
        {
            "start_pos": 349,
            "end_pos": 349,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine; by BARK1",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51681",
                    "url": "https://www.uniprot.org/uniprotkb/P51681"
                },
                {
                    "database": "iPTMnet",
                    "id": "P51681",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P51681"
                },
                {
                    "database": "PubMed",
                    "id": "10085131",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10085131"
                },
                {
                    "database": "PubMed",
                    "id": "21148810",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/21148810"
                },
                {
                    "database": "PubMed",
                    "id": "29283386",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/29283386"
                }
            ],
            "site_lbl": "Ser349",
            "uniprot_canonical_ac": "P51681-1"
        }
    ],
    "record_id": "pubmed.10085131",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 4
                },
                {
                    "field": "total_sites",
                    "count": 4
                }
            ],
            "sort_fields": [
                "start_pos",
                "end_pos",
                "kinase_uniprot_canonical_ac",
                "kinase_gene_name",
                "residue",
                "comment",
                "site_lbl",
                "uniprot_canonical_ac"
            ]
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}