{ "uniprot_canonical_ac": "A0A1D5PS75-1", "uniprot_ac": "A0A1D5PS75", "uniprot_id": "A0A1D5PS75_CHICK", "mass": { "chemical_mass": 60470.0, "monoisotopic_mass": 60470.0 }, "refseq": { "ac": "XP_004938456", "name": "male-specific lethal 3 homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004938456" }, "gene_names": [ { "name": "MSL3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75", "id": "A0A1D5PS75" }, { "name": "MSL3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004938456", "id": "XP_004938456" } ], "protein_names": [ { "name": "MSL complex subunit 3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75/entry#names_and_taxonomy", "id": "A0A1D5PS75" }, { "name": "Male-specific lethal 3 homolog", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75/entry#names_and_taxonomy", "id": "A0A1D5PS75" }, { "name": "Male-specific lethal-3 homolog 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75/entry#names_and_taxonomy", "id": "A0A1D5PS75" }, { "name": "Male-specific lethal-3 protein-like 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75/entry#names_and_taxonomy", "id": "A0A1D5PS75" }, { "name": "male-specific lethal 3 homolog isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004938456", "id": "XP_004938456" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_004938456", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004938456" } ] }, { "annotation": "Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction. The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac. The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome. X up-regulation is required to compensate for autosomal biallelic expression. The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA. Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. May play a role X inactivation in females.", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5P177", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P177#function" }, { "database": "UniProtKB", "id": "ARBA00059382", "url": "https://www.uniprot.org/uniprotkb/ARBA00059382#function" }, { "database": "UniProtKB", "id": "A0A1D5PS75", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75#function" }, { "database": "UniProtKB", "id": "A0A8V0XDN7", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XDN7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PS75", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "MSL3", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75", "locus": {} } ], "crossref": [ { "id": "A0A1D5PS75", "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PS75", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000041433", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000041433", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18983", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18983", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "418641", "url": "https://www.ncbi.nlm.nih.gov/gene/418641", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000953", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000953", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008676", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008676", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026541", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026541", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053820", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053820", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "gga:418641", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:418641", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DTEYAHL", "url": "https://omabrowser.org/oma/group/DTEYAHL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1D5P177", "url": "https://www.orthodb.org/?gene=A0A1D5P177", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A1D5PS75", "url": "https://www.orthodb.org/?gene=A0A1D5PS75", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0X7V1", "url": "https://www.orthodb.org/?gene=A0A8V0X7V1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0XDN7", "url": "https://www.orthodb.org/?gene=A0A8V0XDN7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10880", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10880", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10880:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10880:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05712", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05712", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF22732", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22732", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-3214847", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-3214847", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_004938456", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004938456", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A1D5P177", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P177", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5P177-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P177-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PS75", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PS75-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0X7V1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X7V1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0X7V1-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X7V1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XDN7", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XDN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XDN7-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XDN7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSRGMKFKFHRGERVLCFEPDPTKAKVLYDAKIVDIIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAEDHVLRDTDENRRLQRKLARKAVARMRRKGRKKRRCRLPGVDSVLKSLPAEENDHNSEKTVSSSSDDSDEGTDEEIKSEESDIEERTEMKEDQDTHSKREMEERAINIEIPEVLKKKLEEDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERSRHHQVTPHANMNLHYVPPEKNVELCKEMVDGLRITFDFTLPLILLYPYEQAQFKKVTSSKFFLPIKENSTNTNRNQEELSPSPPLLNPPTPQSTDSQPATAEPATPKRRKAEPEILQSLRRSTRHTSNCDRLSESSASPQPKRRHLETPTSMPKLFLHLEKKTPVHSGSSSPITLTPSKEGSAVFTGFEGRRNNELNEVLSWKLMPENYPPSDQPPPPSYIYGSQHLLRMFVKLPEILGKMCFPDKNLKALVKHFEMFLRFLAEYHDDFFPESAYVAACEAYYSTKNPRAIY", "length": 522, "header": "tr|A0A1D5PS75-1|A0A1D5PS75_CHICK Isoform 1 of MSL complex subunit 3 OS=Gallus gallus OX=9031 GN=MSL3 PE=4 SV=1 CANONICAL=A0A1D5PS75-1" }, "isoforms": [ { "isoform_ac": "A0A1D5P177-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75/entry#A0A1D5P177-1", "sequence": { "sequence": "MTSRGMKFKFHRGERVLCFEPDPTKAKVLYDAKIVDIIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAEDHVLRDTDENRRLQRKLARKAVARMRRKGRKKRRCRLPGVDSVLKSLPAEENDHNSEKTVSSSSDDSDEGTDEEIKSEESDIEERTEMKEDQDTHSKREMEERAINIEIPEVLKKKLEEDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERSRHHQVTPHANMNLHYVPPEKNVELCKEMVDGLRITFDFTLPLILLYPYEQAQFKKVTSSKFFLPIKENSTNTNRNQEELSPSPPLLNPPTPQSTDSQPATAEPATPKRRKAEPEILQSLRRSTRHTSNCDRLSESSASPQPKRRHLETPTSMPKLFLHLEKKTPVHSGSSSPITLTPSKEGSAVFTGFEGRRNNELNEVLSWKLMPENYPPSDQPPPPSYIYGSQHLLRMFVKLPEILGKMCFPDKNLKALVKHFEMFLRPYLCLKCPHPVIWIS", "length": 505, "header": "tr|A0A1D5P177-1|A0A1D5P177_CHICK Computationally mapped isoform of MSL complex subunit 3 OS=Gallus gallus OX=9031 GN=MSL3 PE=4 SV=1 CANONICAL=A0A1D5PS75-1" }, "locus": { "chromosome": "1", "start_pos": 124149181, "end_pos": 124136321, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010004454.1", "url": "https://www.ensembl.org/id/ENSGALT00010004454.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010002708.1", "url": "https://www.ensembl.org/id/ENSGALP00010002708.1" } ] } }, { "isoform_ac": "A0A1D5PS75-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75/entry#A0A1D5PS75-1", "sequence": { "sequence": "MTSRGMKFKFHRGERVLCFEPDPTKAKVLYDAKIVDIIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAEDHVLRDTDENRRLQRKLARKAVARMRRKGRKKRRCRLPGVDSVLKSLPAEENDHNSEKTVSSSSDDSDEGTDEEIKSEESDIEERTEMKEDQDTHSKREMEERAINIEIPEVLKKKLEEDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERSRHHQVTPHANMNLHYVPPEKNVELCKEMVDGLRITFDFTLPLILLYPYEQAQFKKVTSSKFFLPIKENSTNTNRNQEELSPSPPLLNPPTPQSTDSQPATAEPATPKRRKAEPEILQSLRRSTRHTSNCDRLSESSASPQPKRRHLETPTSMPKLFLHLEKKTPVHSGSSSPITLTPSKEGSAVFTGFEGRRNNELNEVLSWKLMPENYPPSDQPPPPSYIYGSQHLLRMFVKLPEILGKMCFPDKNLKALVKHFEMFLRFLAEYHDDFFPESAYVAACEAYYSTKNPRAIY", "length": 522, "header": "tr|A0A1D5PS75-1|A0A1D5PS75_CHICK Isoform 1 of MSL complex subunit 3 OS=Gallus gallus OX=9031 GN=MSL3 PE=4 SV=1 CANONICAL=A0A1D5PS75-1" }, "locus": { "chromosome": "1", "start_pos": 124149181, "end_pos": 124127620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010004457.1", "url": "https://www.ensembl.org/id/ENSGALT00010004457.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010002710.1", "url": "https://www.ensembl.org/id/ENSGALP00010002710.1" } ] } }, { "isoform_ac": "A0A8V0X7V1-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75/entry#A0A8V0X7V1-1", "sequence": { "sequence": "MCFCQWLWIVDIIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAEDHVLRDTDENRRLQRKLARKAVARMRRKGRKKRRCRLPGVDSVLKSLPAEENDHNSEKTVSSSSDDSDEGTDEEIKSEESDIEERTEMKEDQDTHSKREMEERAINIEIPEVLKKKLEEDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERSRHHQVTPHANMNLHYVPPEKNVELCKEMVDGLRITFDFTLPLILLYPYEQAQFKKVTSSKFFLPIKENSTNTNRNQEELSPSPPLLNPPTPQSTDSQPATAEPATPKRRKAEPEILQSLRRSTRHTSNCDRLSESSASPQPKRRHLETPTSMPKLFLHLEKKTPVHSGSSSPITLTPSKEGSAVFTGFEGRRNNELNEVLSWKLMPENYPPSDQPPPPSYIYGSQHLLRMFVKLPEILGKMCFPDKNLKALVKHFEMFLRFLAEYHDDFFPESAYVAACEAYYSTKNPRAIY", "length": 497, "header": "tr|A0A8V0X7V1-1|A0A8V0X7V1_CHICK Computationally mapped isoform of Chromo domain-containing protein OS=Gallus gallus OX=9031 GN=MSL3 PE=4 SV=1 CANONICAL=A0A1D5PS75-1" }, "locus": { "chromosome": "1", "start_pos": 124174606, "end_pos": 124127620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010004462.1", "url": "https://www.ensembl.org/id/ENSGALT00010004462.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010002713.1", "url": "https://www.ensembl.org/id/ENSGALP00010002713.1" } ] } }, { "isoform_ac": "A0A8V0XDN7-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75/entry#A0A8V0XDN7-1", "sequence": { "sequence": "MTSRGMKFKFHRGERVLCFEPDPTKAKVLYDAKIVDIIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAEDHVLRDTDENRRLQRKLARKAVARIKGRKKRRCRLPGVDSVLKSLPAEENDHNSEKTVSSSSDDSDEGTDEEIKSEESDIEERTEMKEDQDTHSKREMEERAINIEIPEVLKKKLEEDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERSRHHQVTPHANMNLHYVPPEKNVELCKEMVDGLRITFDFTLPLILLYPYEQAQFKKVTSSKFFLPIKENSTNTNRNQEELSPSPPLLNPPTPQSTDSQPATAEPATPKRRKAEPEILQSLRRSTRHTSNCDRLSESSASPQPKRRHLETPTSMPKLFLHLEKKTPVHSGSSSPITLTPSKEGSAVFTGFEGRRNNELNEVLSWKLMPENYPPSDQPPPPSYIYGSQHLLRMFVKLPEILGKMCFPDKNLKALVKHFEMFLRFLAEYHDDFFPESAYVAACEAYYSTKNPRAIY", "length": 520, "header": "tr|A0A8V0XDN7-1|A0A1D5PS75_CHICK Computationally mapped isoform of MSL complex subunit 3 OS=Gallus gallus OX=9031 GN=MSL3 PE=4 SV=1 CANONICAL=A0A1D5PS75-1" }, "locus": { "chromosome": "1", "start_pos": 124149181, "end_pos": 124127620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010004460.1", "url": "https://www.ensembl.org/id/ENSGALT00010004460.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010002712.1", "url": "https://www.ensembl.org/id/ENSGALP00010002712.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "gga:418641", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:418641", "resource": "KEGG Pathway" }, { "id": "R-GGA-3214847", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-3214847", "resource": "Reactome", "description": "HATs acetylate histones" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A9H7-1", "protein_name": "MSL complex subunit 3", "gene_name": "Msl3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSASKGMKFQFHSGEKVLCFEPDPTKARVLYDAKIIDVIIGKDEKGRKIPEYLIHFNGWNSSSWDRWAAEDHVLHDTDENRRLQRKLAKKAIARLRGTGKKKRRCRLPGVDSVLKSVPVKEKTKNDENSISSTCHESCGEKNGGIKEHRQRRIKVKTKGKKKVLSLRSRKDMDERTITIEIPEVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHAMMHAHMNVHYVPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQTQYKRVTSSKFFLPIKESTTTTNRSQEELSPSPPLLNPSTPQSTESQPPTGEPATPKRRKAEPEALQSLRRSTRHSTNCDRLSESSSSPQPKRRQQDTSTSMPKLFLHLEKKTPVHSRSSSPIPLTPSKDGSAVFAGFEGRRTNEINEVLSWKLVPDNYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY", "length": 526 }, "evidence": [ { "id": "A0A1D5PS75", "url": "https://omabrowser.org/oma/group/A0A1D5PS75/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1BFW0-1", "protein_name": "MSL complex subunit 3", "gene_name": "MSL3", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSASEGMKFKFHSGEKVLCFEPDPTKARVLYDAKIVDVIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAEDHVLRDTDENRRLQRKLAKKAVARLRSTGRKRKRCRLPGVDSVLKSLPADEKDENDENSISSSSDSEEKDGEISEEGDTEEKTEVKEGPELHTKKEMEERTITIEIPDVLKKKLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHVIPHANMNVHYIPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQVQYKKVTSSKFFLPIKESTTSTNRNQEELSPSPPLLNPSTPQSTESQPTSGEPTTPKRRKGEPEAFQSLRRSTRHSANCDRLSESSASPQPKRRQQDTSASMPKLFLHLEKKTPVHSRSSSPVPLTPSKEGSAVFAGFEGRRTNEINEVLSWKLVPDSYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY", "length": 520 }, "evidence": [ { "id": "A0A1D5PS75", "url": "https://omabrowser.org/oma/group/A0A1D5PS75/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "G3HH51-1", "protein_name": "MSL complex subunit 3", "gene_name": "Msl3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSASEGMKFQFHSGEKVLCFEPDATKARVLYDAKIVDVIVGKDEKGRKIPEYLIHFNGWNSSWDRWASEDHVLHDTDENRRLQRKLAKKAIARLRGAGGKKRRCRLPGVDSVLKSVPVKETTQNDENSISSTCHDSSGEKNEEIKEHRQRRIKVKTKAKKKVLSLRSRKDMDERTITIDIPEVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHAMMHAHMNVHYVPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQAQYKKVTSSKCFLPIKESTTTTNRSQEELSPSPPLLNPSTPQSTESQPLSGEPATPKRRKADPEALQSLRRSTRHSTNCDRLSESSSSPQPKRRQQDTSASMPKLFLHLEKKTPVHSRSSSPIPLTPSKEGSAVFAGFEGRRTNEINEVLSWKLVPDNYPPGDQPPPPSFIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY", "length": 525 }, "evidence": [ { "id": "A0A1D5PS75", "url": "https://omabrowser.org/oma/group/A0A1D5PS75/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8N5Y2-1", "protein_name": "MSL complex subunit 3", "gene_name": "MSL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSASEGMKFKFHSGEKVLCFEPDPTKARVLYDAKIVDVIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAEDHVLRDTDENRRLQRKLARKAVARLRSTGRKKKRCRLPGVDSVLKGLPTEEKDENDENSLSSSSDCSENKDEEISEESDIEEKTEVKEEPELQTRREMEERTITIEIPEVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHVMPHANMNVHYIPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQAQYKKVTSSKFFLPIKESATSTNRSQEELSPSPPLLNPSTPQSTESQPTTGEPATPKRRKAEPEALQSLRRSTRHSANCDRLSESSASPQPKRRQQDTSASMPKLFLHLEKKTPVHSRSSSPIPLTPSKEGSAVFAGFEGRRTNEINEVLSWKLVPDNYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY", "length": 521 }, "evidence": [ { "id": "A0A1D5PS75", "url": "https://omabrowser.org/oma/group/A0A1D5PS75/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WVG9-1", "protein_name": "MSL complex subunit 3", "gene_name": "Msl3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSASEGMKFQFHSGEKVLCFEPDPTKARVLYDAKIIDVIIGKDEKGRKIPEYLIHFNGWNRSWDRWAAEEHVLHDTDENRRLQRKLAKKAIARLRGTGKKKRRCRLPGVDSVLKSVPVKEKSKNDENSVSSTCHESCGEKNGGIKEHRQRRIKVKAKAKKKVLSLRSRKEMDERTITIDIPDVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHAMMHTHMNVHYVPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQTQYKRVTSSKFFLPIKESTTTTNRSQEELSPSPPLLNPSTPQSTESQPPTGEPATPKRRKAEPEALQSLRRSTRHSTNCDRLSESSSSPQPKRRQQDTSASMPKLFLHLEKKTPVHSRSSSPIPLTPSKDGSAVFAGFEGRRPNEINEVLSWKLVPDNYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY", "length": 525 }, "evidence": [ { "id": "A0A1D5PS75", "url": "https://omabrowser.org/oma/group/A0A1D5PS75/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PS75", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75" } ], "pmid": "" }, { "name": "NuA4 histone acetyltransferase complex", "id": "GO:0035267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035267", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PS75", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75" } ], "pmid": "" }, { "name": "MSL complex", "id": "GO:0072487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072487", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PS75", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PS75", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PS75", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PS75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A1D5PS75-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 522, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A1D5PS75-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A1D5PS75" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 298, "end_pos": 300 }, { "start_pos": 59, "end_pos": 61 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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