{ "uniprot_canonical_ac": "A0A1D5PLX8-1", "uniprot_ac": "A0A1D5PLX8", "uniprot_id": "A0A1D5PLX8_CHICK", "mass": { "chemical_mass": 92064.0, "monoisotopic_mass": 92064.0 }, "refseq": { "ac": "XP_004939382", "name": "diacylglycerol kinase beta isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004939382" }, "gene_names": [ { "name": "DGKB", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8", "id": "A0A1D5PLX8" }, { "name": "DGKB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004939382", "id": "XP_004939382" } ], "protein_names": [ { "name": "Diacylglycerol kinase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8/entry#names_and_taxonomy", "id": "A0A1D5PLX8" }, { "name": "2.7.1.107", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8/entry#names_and_taxonomy", "id": "A0A1D5PLX8" }, { "name": "DAG kinase", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8/entry#names_and_taxonomy", "id": "A0A1D5PLX8" }, { "name": "diacylglycerol kinase beta isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004939382", "id": "XP_004939382" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_004939382", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004939382" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "DGKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8", "locus": { "chromosome": "2", "start_pos": 27288801, "end_pos": 27623438, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010004094", "url": "https://www.ensembl.org/id/ENSGALG00010004094" } ] } } ], "crossref": [ { "id": "A0A1D5PLX8", "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PLX8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000033561", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000033561", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20845", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20845", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20891", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20891", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "772367", "url": "https://www.ncbi.nlm.nih.gov/gene/772367", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001206", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001206", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038199", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038199", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046349", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047470", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047470", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "gga:772367", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:772367", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HNGKSDH", "url": "https://omabrowser.org/oma/group/HNGKSDH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1D5PLX8", "url": "https://www.orthodb.org/?gene=A0A1D5PLX8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0XFY5", "url": "https://www.orthodb.org/?gene=A0A8V0XFY5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0XIN3", "url": "https://www.orthodb.org/?gene=A0A8V0XIN3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0XLE3", "url": "https://www.orthodb.org/?gene=A0A8V0XLE3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0XN17", "url": "https://www.orthodb.org/?gene=A0A8V0XN17", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0XN21", "url": "https://www.orthodb.org/?gene=A0A8V0XN21", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11255", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11255", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11255:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11255:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00130", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00130", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00609", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00609", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00781", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00781", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14513", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14513", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-114508", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-114508", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_004939382", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004939382", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10272", "url": "https://www.rhea-db.org/rhea/10272", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40323", "url": "https://www.rhea-db.org/rhea/40323", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40327", "url": "https://www.rhea-db.org/rhea/40327", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "43428", "url": "https://www.rhea-db.org/rhea/43428", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PLX8-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XFY5", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XFY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XFY5-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XFY5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XIN3", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XIN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XIN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XIN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XLE3", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XLE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XLE3-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XLE3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XN17", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XN17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XN17-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XN17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XN21", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XN21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0XN21-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XN21-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSQEKWLNLSPGEFSQLQKYAEYSTKKIKDVLEEFHGSGVLAKYNPEGKQDILNQTIDLEGFKLFMKTFLEAELPDDFIEHLFTSFSNKVSHCSPLIKNKPQLLSGVKVSEERWKQMPGLRLNKGTSTSRPPTPANLNLPDAIQLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGYLDSSELENIIAQMMHVAEYLEWDITELSPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVSRAPASCIKTYVKSKKNTDVMHHFWVEGNCPTKCDKCHKTIKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTSICPVVLTLPTSGGLLPEERQATVKKEKGCLQQMNKLGERNKMQRANSITVDGQGLQITPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLAGNGPMPGLNFFRDVPEFRVLACGGDGTVGWILDCIEKANLLKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSSEILLDRWKFEVIPNDKDEKGDPVPYNIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGIQLDLINISLEGIAILNIPSMHGGSNLWGETKKRRSHRRTEKKRSDKRTTVTDAKELKFVCQDLSDQLMEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFSSIIKRTRNHSKE", "length": 814, "header": "tr|A0A1D5PLX8-1|A0A1D5PLX8_CHICK Isoform 1 of Diacylglycerol kinase OS=Gallus gallus OX=9031 GN=DGKB PE=3 SV=2 CANONICAL=A0A1D5PLX8-1" }, "isoforms": [ { "isoform_ac": "A0A1D5PLX8-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8/entry#A0A1D5PLX8-1", "sequence": { "sequence": "MTSQEKWLNLSPGEFSQLQKYAEYSTKKIKDVLEEFHGSGVLAKYNPEGKQDILNQTIDLEGFKLFMKTFLEAELPDDFIEHLFTSFSNKVSHCSPLIKNKPQLLSGVKVSEERWKQMPGLRLNKGTSTSRPPTPANLNLPDAIQLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGYLDSSELENIIAQMMHVAEYLEWDITELSPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVSRAPASCIKTYVKSKKNTDVMHHFWVEGNCPTKCDKCHKTIKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTSICPVVLTLPTSGGLLPEERQATVKKEKGCLQQMNKLGERNKMQRANSITVDGQGLQITPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLAGNGPMPGLNFFRDVPEFRVLACGGDGTVGWILDCIEKANLLKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSSEILLDRWKFEVIPNDKDEKGDPVPYNIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGIQLDLINISLEGIAILNIPSMHGGSNLWGETKKRRSHRRTEKKRSDKRTTVTDAKELKFVCQDLSDQLMEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFSSIIKRTRNHSKE", "length": 814, "header": "tr|A0A1D5PLX8-1|A0A1D5PLX8_CHICK Isoform 1 of Diacylglycerol kinase OS=Gallus gallus OX=9031 GN=DGKB PE=3 SV=2 CANONICAL=A0A1D5PLX8-1" }, "locus": { "chromosome": "2", "start_pos": 27591477, "end_pos": 27291437, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010009529.1", "url": "https://www.ensembl.org/id/ENSGALT00010009529.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010005611.1", "url": "https://www.ensembl.org/id/ENSGALP00010005611.1" } ] } }, { "isoform_ac": "A0A8V0XFY5-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8/entry#A0A8V0XFY5-1", "sequence": { "sequence": "MTSQEKWLNLSPGEFSQLQKYAEYSTKKIKDVLEEFHGSGVLAKYNPEGTIDLEGFKLFMKTFLEAELPDDFIEHLFTSFSNKVSHCSPLIKNKPQLLSGVKVSEERWKQMPGLRLNKGTSTSRPPTPANLNLPDAIQLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGYLDSSELENIIAQMMHVAEYLEWDITELSPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVSRAPASCIKTYVKSKKNTDVMHHFWVEGNCPTKCDKCHKTIKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTSICPVVLTLPTSGGLLPEERQATVKKEKGCLQQMNKLGERNKMQRANSITVDGQGLQITPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLAGNGPMPGLNFFRDVPEFRVLACGGDGTVGWILDCIEKANLLKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSSEILLDRWKFEVIPNDKDEKGDPVPYNIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGIQLDLINISLEGIAILNIPSMHGGSNLWGETKKRRSHRRTEKKRSDKRTTVTDAKELKFVCQDLSDQLMEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFSSIIKRTRNHSKE", "length": 807, "header": "tr|A0A8V0XFY5-1|A0A1D5PLX8_CHICK Computationally mapped isoform of Diacylglycerol kinase OS=Gallus gallus OX=9031 GN=DGKB PE=3 SV=1 CANONICAL=A0A1D5PLX8-1" }, "locus": { "chromosome": "2", "start_pos": 27591477, "end_pos": 27291437, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010009531.1", "url": "https://www.ensembl.org/id/ENSGALT00010009531.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010005613.1", "url": "https://www.ensembl.org/id/ENSGALP00010005613.1" } ] } }, { "isoform_ac": "A0A8V0XIN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8/entry#A0A8V0XIN3-1", "sequence": { "sequence": "MTSQEKWLNLSPGEFSQLQKYAEYSTKKIKDVLEEFHGSGVLAKYNPEGTIDLEGFKLFMKTFLEAELPDDFIEHLFTSFSNKVSHCSPLIKNKPQLLSGVKVSEERWKQMPGLRLNKGTSTSRPPTPANLNLPDAIQLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGYLDSSELENIIAQMMHVAEYLEWDITELSPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVSRAPASCIKTYVKSKKNTDVMHHFWVEGNCPTKCDKCHKTIKCYQGLTGLHCVWCQITERQATVKKEKGCLQQMNKLGERNKMQRANSITVDGQGLQITPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLAGNGPMPGLNFFRDVPEFRVLACGGDGTVGWILDCIEKANLLKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSSEILLDRWKFEVIPNDKDEKGDPVPYNIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGIQLDLINISLEGIAILNIPSMHGGSNLWGETKKRRSHRRTEKKRSDKRTTVTDAKELKFVCQDLSDQLMEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFSSIIKRTRNHSKE", "length": 763, "header": "tr|A0A8V0XIN3-1|A0A1D5PLX8_CHICK Computationally mapped isoform of Diacylglycerol kinase OS=Gallus gallus OX=9031 GN=DGKB PE=3 SV=1 CANONICAL=A0A1D5PLX8-1" }, "locus": { "chromosome": "2", "start_pos": 27591477, "end_pos": 27291437, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010009538.1", "url": "https://www.ensembl.org/id/ENSGALT00010009538.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010005616.1", "url": "https://www.ensembl.org/id/ENSGALP00010005616.1" } ] } }, { "isoform_ac": "A0A8V0XLE3-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8/entry#A0A8V0XLE3-1", "sequence": { "sequence": "MERMKNKFWYFEFGTSETFSATCKKLHESVEIECDGIQLDLINISLEGIAILNIPSMHGGSNLWGETKKRRSHRRTEKKRSDKRTTVTDAKELKFVCQDLSDQLMEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFSSIIKRTRNHSKE", "length": 194, "header": "tr|A0A8V0XLE3-1|A0A1D5PLX8_CHICK Computationally mapped isoform of Diacylglycerol kinase OS=Gallus gallus OX=9031 GN=DGKB PE=3 SV=1 CANONICAL=A0A1D5PLX8-1" }, "locus": { "chromosome": "2", "start_pos": 27414480, "end_pos": 27291437, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010009522.1", "url": "https://www.ensembl.org/id/ENSGALT00010009522.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010005607.1", "url": "https://www.ensembl.org/id/ENSGALP00010005607.1" } ] } }, { "isoform_ac": "A0A8V0XN17-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8/entry#A0A8V0XN17-1", "sequence": { "sequence": "MTSQEKWLNLSPGEFSQLQKYAEYSTKKIKDVLEEFHGSGVLAKYNPEGKQDILNQTIDLEGFKLFMKTFLEAELPDDFIEHLFTSFSNKVSHCSPLIKNKPQLLSGVKVSEERWKQMPGLRLNKGTSTSRPPTPANLNLPDAIQLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGYLDSSELENIIAQMMHVAEYLEWDITELSPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVSRAPASCIKTYVKSKKNTDVMHHFWVEGNCPTKCDKCHKTIKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTSICPVVLERQATVKKEKGCLQQMNKLGERNKMQRANSITVDGQGLQITPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLAGNGPMPGLNFFRDVPEFRVLACGGDGTVGWILDCIEKANLLKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSSEILLDRWKFEVIPNDKDEKGDPVPYNIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGIQLDLINISLEGIAILNIPSMHGGSNLWGETKKRRSHRRTEKKRSDKRTTVTDAKELKFVCQDKNYPQEPSPYVDGSSSKNWSFLLYHQKNKEPQQGISLCSLVFRKSISFVGLWNIYA", "length": 764, "header": "tr|A0A8V0XN17-1|A0A1D5PLX8_CHICK Computationally mapped isoform of Diacylglycerol kinase OS=Gallus gallus OX=9031 GN=DGKB PE=3 SV=1 CANONICAL=A0A1D5PLX8-1" }, "locus": { "chromosome": "2", "start_pos": 27591477, "end_pos": 27291372, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010009528.1", "url": "https://www.ensembl.org/id/ENSGALT00010009528.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010005610.1", "url": "https://www.ensembl.org/id/ENSGALP00010005610.1" } ] } }, { "isoform_ac": "A0A8V0XN21-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8/entry#A0A8V0XN21-1", "sequence": { "sequence": "MTSQEKWLNLSPGEFSQLQKYAEYSTKKIKDVLEEFHGSGVLAKYNPEGKQDILNQTIDLEGFKLFMKTFLEAELPDDFIEHLFTSFSNKVSHCSPLIKNKPQLLSGVKVSEERWKQMPGLRLNKGTSTSRPPTPANLNLPDAIQLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGYLDSSELENIIAQMMHVAEYLEWDITELSPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVSRAPASCIKTYVKSKKNTDVMHHFWVEGNCPTKCDKCHKTIKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTSICPVVLERQATVKKEKGCLQQMNKLGERNKMQRANSITVDGQGLQITPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLAGNGPMPGLNFFRDVPEFRVLACGGDGTVGWILDCIEKANLLKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSSEILLDRWKFEVIPNDKDEKGDPVPYNIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGIQLDLINISLEGIAILNIPSMHGGSNLWGETKKRRSHRRTEKKRSDKRTTVTDAKELKFVCQDLSDQLMEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFSSIIKRTRNHSKE", "length": 803, "header": "tr|A0A8V0XN21-1|A0A1D5PLX8_CHICK Computationally mapped isoform of Diacylglycerol kinase OS=Gallus gallus OX=9031 GN=DGKB PE=3 SV=1 CANONICAL=A0A1D5PLX8-1" }, "locus": { "chromosome": "2", "start_pos": 27591477, "end_pos": 27291437, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010009534.1", "url": "https://www.ensembl.org/id/ENSGALT00010009534.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010005615.1", "url": "https://www.ensembl.org/id/ENSGALP00010005615.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 134, "start_aa": "Thr", "end_pos": 134, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr134", "evidence": [ { "id": "GLY_001161", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001161" } ], "filter_code": "00000000000000001000.00000000001000.0.xxxxx" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "gga:772367", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:772367", "resource": "KEGG Pathway" }, { "id": "R-GGA-114508", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-114508", "resource": "Reactome", "description": "Effects of PIP2 hydrolysis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q1NKG7-1", "protein_name": "Diacylglycerol kinase", "gene_name": "DGKB", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGTIDFEGFKLFMKTFLEAELPDDFTTHLFMSFSNKFPHSSPMVKSKPALLSSGLKMNKGAITPPRTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKKNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLTLPTSGVSAPEERQATVKREKGSSQQSNKVTDKNKMQRANSVTVDGQGLQITPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLAGNGPMPGLNFFRDVPDFRVLACGGDGTVGWILDCIEKANVVKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTLIDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKIIHKNQAPMLMGPPPKTGLFCSLVKRTRNRSKE", "length": 795 }, "evidence": [ { "id": "A0A1D5PLX8", "url": "https://omabrowser.org/oma/group/A0A1D5PLX8/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "P49621-1", "protein_name": "Diacylglycerol kinase beta", "gene_name": "Dgkb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPNVKSKPALLSGGLRMNKGAITPPRSSPANTCFPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIIGQMMHVAEYLEWDVTELNPILHEMMEEIDYDRDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCARAPPSCIKTYVKSKKNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQTTLHNKCASHLKPECDCGPLKDHILPPTTICPVVLTMPTAGTSVPEERQSTAKKEKGSSQQPNKVTDKNKMQRANSVTMDGQGLQITPIPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLHFFRDVPDFRVLACGGDGTVGWILDCIEKANVVKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIESSTEIMLDRWKFEVTPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLQGIAILNIPSMHGGSNLWGESKKKRSHRRIEKKGSDKRPTLTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLIKRTRNRSKE", "length": 801 }, "evidence": [ { "id": "A0A1D5PLX8", "url": "https://omabrowser.org/oma/group/A0A1D5PLX8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6NS52-1", "protein_name": "Diacylglycerol kinase beta", "gene_name": "Dgkb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPNVKSKPALLSGGLRMNKGAITPPRSSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIIGQMMHVAEYLEWDVTELNPILHEMMEEIDYDRDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKKNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQTTLHNKCASHLKPECDCGPLKDHILPPTTICPVVLTMPSAGASVPEERQSTAKKEKSSSQQPNKATDKNKMQRANSVTMDGQGLQITPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLHFFRDVPDFRVLACGGDGTVGWILDCIEKANVVKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIESSTEIMLDRWKFEVTPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKKRSHRRIEKKGSDKRPTLTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLIKRTRNRSKE", "length": 802 }, "evidence": [ { "id": "A0A1D5PLX8", "url": "https://omabrowser.org/oma/group/A0A1D5PLX8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y6T7-1", "protein_name": "Diacylglycerol kinase beta", "gene_name": "DGKB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLVKRTRNRSKE", "length": 804 }, "evidence": [ { "id": "A0A1D5PLX8", "url": "https://omabrowser.org/oma/group/A0A1D5PLX8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP-dependent diacylglycerol kinase activity", "id": "GO:0004143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004143", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" }, { "name": "phospholipase C-activating G protein-coupled receptor signaling pathway", "id": "GO:0007200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007200", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" }, { "name": "diacylglycerol metabolic process", "id": "GO:0046339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046339", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" }, { "name": "phosphatidic acid biosynthetic process", "id": "GO:0006654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006654", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" }, { "name": "response to bacterium", "id": "GO:0009617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009617", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" }, { "name": "modulation of chemical synaptic transmission", "id": "GO:0050804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050804", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" }, { "name": "regulation of postsynapse organization", "id": "GO:0099175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099175", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PLX8", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" }, { "start_pos": 563, "end_pos": 565, "annotation": "n_glycosylation_sequon" }, { "start_pos": 663, "end_pos": 665, "annotation": "n_glycosylation_sequon" }, { "start_pos": 810, "end_pos": 812, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10272", "name": "", "equation": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PLX8-1", "A0A8V0ZWR7-1", "A0A8V0ZZL0-1", "A0A8V0ZUG5-1", "A0A8V1AJ79-1", "A0A8V0X8Y2-1", "A0A8V0YBN5-1", "A0A8V0YKR7-1", "A0A8V0YNI7-1", "A0A8V0ZLQ0-1", "A0A8V0YKJ3-1" ], "evidence": [ { "id": "10272", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10272" } ] }, { "id": "40323", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PLX8-1", "A0A8V0ZZL0-1", "A0A8V0ZWR7-1", "A0A8V0YNI7-1", "A0A8V0ZLQ0-1" ], "evidence": [ { "id": "40323", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40323" } ] }, { "id": "40327", "name": "", "equation": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PLX8-1", "A0A8V0X8Y2-1", "A0A8V0ZZL0-1", "A0A8V0ZUG5-1", "A0A8V0ZWR7-1", "A0A8V1AJ79-1", "A0A8V0YNI7-1", "A0A8V0YBN5-1", "A0A8V0YKR7-1", "A0A8V0ZLQ0-1", "A0A8V0YKJ3-1" ], "evidence": [ { "id": "40327", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40327" } ] }, { "id": "43428", "name": "", "equation": "1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PLX8-1", "A0A8V0ZZL0-1", "A0A8V0ZWR7-1", "A0A8V0ZLQ0-1" ], "evidence": [ { "id": "43428", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43428" } ] }, { "id": "R-GGA-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-ALL-114519" ], "output_participant_list": [ "R-ALL-76108" ], "enzyme_list": [ "A0A8V0YKR7-1", "A0A1D5PLX8-1" ], "evidence": [ { "id": "R-GGA-426240", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-426240" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-114519", "participant_name": "DAG [plasma membrane]", "crossref": [ { "id": "17815", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-76108", "participant_name": "1,2-daG3P [cytosol]", "crossref": [ { "id": "58608", "database": "ChEBI", "url": "" }, { "id": "DIACYLGLYCEROL-PYROPHOSPHATE", "database": "AraCyc", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" }, { "id": "25202796", "database": "PubChem Compound", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A1D5PLX8", "gene_name": "DGKB", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A1D5PLX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A1D5PLX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PLX8" } ] } ] }, { "uniprot_ac": "A0A8V0X8Y2", "gene_name": "DGKH", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A8V0X8Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X8Y2" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A8V0X8Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X8Y2" } ] } ] }, { "uniprot_ac": "A0A8V0YBN5", "gene_name": "DGKQ", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A8V0YBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YBN5" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A8V0YBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YBN5" } ] } ] }, { "uniprot_ac": "A0A8V0YKJ3", "gene_name": "AGK", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A8V0YKJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YKJ3" } ] }, { "ec_number": "2.7.1.94", "activity": "a monoacylglycerol + ATP = a monoacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A8V0YKJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YKJ3" } ] }, { "ec_number": "2.7.1.138", "activity": "an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A8V0YKJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YKJ3" } ] }, { "ec_number": "2.7.1.138", "activity": "", "evidence": [ { "id": "A0A8V0YKJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YKJ3" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A8V0YKJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YKJ3" } ] }, { "ec_number": "2.7.1.94", "activity": "", "evidence": [ { "id": "A0A8V0YKJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YKJ3" } ] } ] }, { "uniprot_ac": "A0A8V0YKR7", "gene_name": "DGKK", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A8V0YKR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YKR7" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A8V0YKR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YKR7" } ] } ] }, { "uniprot_ac": "A0A8V0YNI7", "gene_name": "DGKI", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A8V0YNI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YNI7" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A8V0YNI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YNI7" } ] } ] }, { "uniprot_ac": "A0A8V0ZLQ0", "gene_name": "DGKZ", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A8V0ZLQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZLQ0" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A8V0ZLQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZLQ0" } ] } ] }, { "uniprot_ac": "A0A8V0ZUG5", "gene_name": "DGKD", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A8V0ZUG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZUG5" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A8V0ZUG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZUG5" } ] } ] }, { "uniprot_ac": "A0A8V0ZWR7", "gene_name": "DGKG", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A8V0ZWR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZWR7" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A8V0ZWR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZWR7" } ] } ] }, { "uniprot_ac": "A0A8V0ZZL0", "gene_name": "DGKA", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A8V0ZZL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZZL0" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A8V0ZZL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZZL0" } ] } ] }, { "uniprot_ac": "A0A8V1AJ79", "gene_name": "DGKE", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A8V1AJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AJ79" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A8V1AJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AJ79" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A1D5PLX8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 814, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A1D5PLX8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A1D5PLX8" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.107", "ec_name": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "2.7.1.107", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107" }, { "id": "2.7.1.107", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.107" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 134 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 55, "end_pos": 57 }, { "start_pos": 563, "end_pos": 565 }, { "start_pos": 663, "end_pos": 665 }, { "start_pos": 810, "end_pos": 812 }, { "start_pos": 9, "end_pos": 11 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }