{
    "uniprot_canonical_ac": "A0A1D5PL45-1",
    "uniprot_ac": "A0A1D5PL45",
    "uniprot_id": "A0A1D5PL45_CHICK",
    "mass": {
        "chemical_mass": 53161.0,
        "monoisotopic_mass": 53161.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "ADSS2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45",
            "id": "A0A1D5PL45"
        },
        {
            "name": "ADSS",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45",
            "id": "A0A1D5PL45"
        }
    ],
    "protein_names": [
        {
            "name": "Adenylosuccinate synthetase isozyme 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45/entry#names_and_taxonomy",
            "id": "A0A1D5PL45"
        },
        {
            "name": "6.3.4.4",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45/entry#names_and_taxonomy",
            "id": "A0A1D5PL45"
        },
        {
            "name": "AMPSase 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45/entry#names_and_taxonomy",
            "id": "A0A1D5PL45"
        },
        {
            "name": "AdSS 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45/entry#names_and_taxonomy",
            "id": "A0A1D5PL45"
        },
        {
            "name": "Adenylosuccinate synthetase, acidic isozyme",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45/entry#names_and_taxonomy",
            "id": "A0A1D5PL45"
        },
        {
            "name": "Adenylosuccinate synthetase, liver isozyme",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45/entry#names_and_taxonomy",
            "id": "A0A1D5PL45"
        },
        {
            "name": "IMP--aspartate ligase 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45/entry#names_and_taxonomy",
            "id": "A0A1D5PL45"
        },
        {
            "name": "L-type adenylosuccinate synthetase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45/entry#names_and_taxonomy",
            "id": "A0A1D5PL45"
        }
    ],
    "function": [
        {
            "annotation": "Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A8V0Y1S7",
                    "url": "https://www.uniprot.org/uniprotkb/A0A8V0Y1S7#function"
                },
                {
                    "database": "HAMAP",
                    "id": "MF_03125",
                    "url": "https://hamap.expasy.org/signature/MF_03125"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A8V0Y5N1",
                    "url": "https://www.uniprot.org/uniprotkb/A0A8V0Y5N1#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "ARBA00003779",
                    "url": "https://www.uniprot.org/uniprotkb/ARBA00003779#function"
                },
                {
                    "database": "HAMAP",
                    "id": "MF_03127",
                    "url": "https://hamap.expasy.org/signature/MF_03127"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A1D5PL45",
                    "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A8V0Y5M5",
                    "url": "https://www.uniprot.org/uniprotkb/A0A8V0Y5M5#function"
                }
            ]
        },
        {
            "annotation": "Plays an important role in the de novo pathway of purine nucleotide biosynthesis.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A8V0Y5N1",
                    "url": "https://www.uniprot.org/uniprotkb/A0A8V0Y5N1#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "RU000520",
                    "url": "https://www.uniprot.org/uniprotkb/RU000520#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A1D5PL45",
                    "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A8V0Y5M5",
                    "url": "https://www.uniprot.org/uniprotkb/A0A8V0Y5M5#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Gallus gallus",
            "taxid": 9031,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1D5PL45",
                    "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45"
                }
            ],
            "common_name": "Chicken",
            "glygen_name": "Chicken",
            "reference_species": "Gallus gallus [9031]"
        }
    ],
    "gene": [
        {
            "name": "ADSS2",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45",
            "locus": {
                "chromosome": "3",
                "start_pos": 34480495,
                "end_pos": 34444905,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSGALG00010008285",
                        "url": "https://www.ensembl.org/id/ENSGALG00010008285"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "A0A1D5PL45",
            "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PL45",
            "database": "AlphaFoldDB",
            "categories": []
        },
        {
            "id": "ENSGALG00000010702",
            "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000010702",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd03108",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03108",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001114",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001114",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR018220",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018220",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027417",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027529",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027529",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR033128",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033128",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR042109",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042109",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR042110",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042110",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR042111",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042111",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A0A1D5PL45",
            "url": "https://www.orthodb.org/?gene=A0A1D5PL45",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A0A8V0Y1S7",
            "url": "https://www.orthodb.org/?gene=A0A8V0Y1S7",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A0A8V0Y5M5",
            "url": "https://www.orthodb.org/?gene=A0A8V0Y5M5",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A0A8V0Y5N1",
            "url": "https://www.orthodb.org/?gene=A0A8V0Y5N1",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11846",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11846",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11846:SF13",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11846:SF13",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00709",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00709",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "15753",
            "url": "https://www.rhea-db.org/rhea/15753",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A1D5PL45",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1D5PL45-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8V0Y1S7",
            "url": "https://www.uniprot.org/uniprotkb/A0A8V0Y1S7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8V0Y1S7-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A8V0Y1S7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8V0Y5M5",
            "url": "https://www.uniprot.org/uniprotkb/A0A8V0Y5M5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8V0Y5M5-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A8V0Y5M5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8V0Y5N1",
            "url": "https://www.uniprot.org/uniprotkb/A0A8V0Y5N1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8V0Y5N1-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A8V0Y5N1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MRHPRPAGRRRGQRGRRALPHVPGEAPERAARAMAEHGAPAPAIPNGGCAARLPGNKVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPKVTAFIGNGVVIHLPGLFEETEKNLKKGKGLEGWEKRLVISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDEFSERFKVLANQYKAIYPTLEIDIEGELKKLKAYMEKVKPMVKDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQMRGKEFGVTTGRKRRCGWLDLVQLRYAYMINGFTALALTKLDILDVFPEIKVGVAYKLDGEVIPHFPANHEVLSKVEVKYETLPGWDTDISNARTFDELPVNAQNYVRFIEMELGVPVKWIGVGKSRESMIQLF",
        "length": 484,
        "header": "tr|A0A1D5PL45-1|A0A1D5PL45_CHICK Isoform 1 of Adenylosuccinate synthetase isozyme 2  OS=Gallus gallus OX=9031 GN=ADSS2 PE=3 SV=1 CANONICAL=A0A1D5PL45-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1D5PL45-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45/entry#A0A1D5PL45-1",
            "sequence": {
                "sequence": "MRHPRPAGRRRGQRGRRALPHVPGEAPERAARAMAEHGAPAPAIPNGGCAARLPGNKVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPKVTAFIGNGVVIHLPGLFEETEKNLKKGKGLEGWEKRLVISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDEFSERFKVLANQYKAIYPTLEIDIEGELKKLKAYMEKVKPMVKDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQMRGKEFGVTTGRKRRCGWLDLVQLRYAYMINGFTALALTKLDILDVFPEIKVGVAYKLDGEVIPHFPANHEVLSKVEVKYETLPGWDTDISNARTFDELPVNAQNYVRFIEMELGVPVKWIGVGKSRESMIQLF",
                "length": 484,
                "header": "tr|A0A1D5PL45-1|A0A1D5PL45_CHICK Isoform 1 of Adenylosuccinate synthetase isozyme 2  OS=Gallus gallus OX=9031 GN=ADSS2 PE=3 SV=1 CANONICAL=A0A1D5PL45-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 34476833,
                "end_pos": 34445044,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSGALT00010019813.1",
                        "url": "https://www.ensembl.org/id/ENSGALT00010019813.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSGALP00010011361.1",
                        "url": "https://www.ensembl.org/id/ENSGALP00010011361.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8V0Y1S7-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45/entry#A0A8V0Y1S7-1",
            "sequence": {
                "sequence": "MKKAEPQIQNKNLGGNNAGHTVVVDSVEYDFHLLPSGIINPKVTAFIGNGVVIHLPGLFEETEKNLKKGKGLEGWEKRLVISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDEFSERFKVLANQYKAIYPTLEIDIEGELKKLKAYMEKVKPMVKDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQMRGKEFGVTTGRKRRCGWLDLVQLRYAYMINGFTALALTKLDILDVFPEIKVGVAYKLDGEVIPHFPANHEVLSKVEVKYETLPGWDTDISNARTFDELPVNAQNYVRFIEMELGVPVKWIGVGKSRESMIQLF",
                "length": 408,
                "header": "tr|A0A8V0Y1S7-1|A0A1D5PL45_CHICK Computationally mapped isoform of Adenylosuccinate synthetase isozyme 2  OS=Gallus gallus OX=9031 GN=ADSS2 PE=3 SV=1 CANONICAL=A0A1D5PL45-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 34476833,
                "end_pos": 34456320,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSGALT00010019803.1",
                        "url": "https://www.ensembl.org/id/ENSGALT00010019803.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSGALP00010011351.1",
                        "url": "https://www.ensembl.org/id/ENSGALP00010011351.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8V0Y5M5-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45/entry#A0A8V0Y5M5-1",
            "sequence": {
                "sequence": "MAEHGAPAPAIPNGGCAARLPGNKVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPKVTAFIGNGVVIHLPGLFEETEKNLKKGKGLEGWEKRLVISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDEFSERFKVLANQYKAIYPTLEIDIEGELKKLKAYMEKVKPMVKDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQMRGKEFGVTTGRKRRCGWLDLVQLRYAYMINGFTALALTKLDILDVFPEIKVGVAYKLDGEVIPHFPANHEVLSKVEVKYETLPGWDTDISNARTFDELPVNAQNYVRFIEMELGVPGK",
                "length": 436,
                "header": "tr|A0A8V0Y5M5-1|A0A1D5PL45_CHICK Computationally mapped isoform of Adenylosuccinate synthetase isozyme 2  OS=Gallus gallus OX=9031 GN=ADSS2 PE=3 SV=1 CANONICAL=A0A1D5PL45-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 34476034,
                "end_pos": 34445143,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSGALT00010019807.1",
                        "url": "https://www.ensembl.org/id/ENSGALT00010019807.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSGALP00010011354.1",
                        "url": "https://www.ensembl.org/id/ENSGALP00010011354.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8V0Y5N1-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45/entry#A0A8V0Y5N1-1",
            "sequence": {
                "sequence": "MRHPRPAGRRRGQRGRRALPHVPGEAPERAARAMAEHGAPAPAIPNGGCAARLPGNKVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPKVTAFIGNGVVIHLPGLFEETEKNLKKGKVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDEFSERFKVLANQYKAIYPTLEIDIEGELKKLKAYMEKVKPMVKDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQMRGKEFGVTTGRKRRCGWLDLVQLRYAYMINGFTALALTKLDILDVFPEIKVGVAYKLDGEVIPHFPANHEVLSKVEVKYETLPGWDTDISNARTFDELPVNAQNYVRFIEMELGVPVKWIGVGKSRESMIQLF",
                "length": 467,
                "header": "tr|A0A8V0Y5N1-1|A0A1D5PL45_CHICK Computationally mapped isoform of Adenylosuccinate synthetase isozyme 2  OS=Gallus gallus OX=9031 GN=ADSS2 PE=3 SV=1 CANONICAL=A0A1D5PL45-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 34476833,
                "end_pos": 34445044,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSGALT00010019811.1",
                        "url": "https://www.ensembl.org/id/ENSGALT00010019811.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSGALP00010011359.1",
                        "url": "https://www.ensembl.org/id/ENSGALP00010011359.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [],
    "pathway": [],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "magnesium ion binding",
                        "id": "GO:0000287",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1D5PL45",
                                "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "GTP binding",
                        "id": "GO:0005525",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1D5PL45",
                                "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "adenylosuccinate synthase activity",
                        "id": "GO:0004019",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004019",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1D5PL45",
                                "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL45"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
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            },
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                "name": "Biological Process",
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            "input_participant_list": [],
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