{ "uniprot_canonical_ac": "A0A1D5PL04-1", "uniprot_ac": "A0A1D5PL04", "uniprot_id": "A0A1D5PL04_CHICK", "mass": { "chemical_mass": 44626.0, "monoisotopic_mass": 44626.0 }, "refseq": { "ac": "XP_004944662", "name": "Krueppel-like factor 15 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004944662" }, "gene_names": [ { "name": "KLF15", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04", "id": "A0A1D5PL04" }, { "name": "KLF15", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004944662", "id": "XP_004944662" } ], "protein_names": [ { "name": "Krueppel-like factor 15", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04/entry#names_and_taxonomy", "id": "A0A1D5PL04" }, { "name": "Krueppel-like factor 15 isoform X3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004944662", "id": "XP_004944662" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052543.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_004944662", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004944662" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "KLF15", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04", "locus": { "chromosome": "12", "start_pos": 10806952, "end_pos": 10833065, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010021173", "url": "https://www.ensembl.org/id/ENSGALG00010021173" } ] } } ], "crossref": [ { "id": "A0A1D5PL04", "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PL04", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000036133", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000036133", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21580", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21580", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "427588", "url": "https://www.ncbi.nlm.nih.gov/gene/427588", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "gga:427588", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:427588", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NAAASWW", "url": "https://omabrowser.org/oma/group/NAAASWW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1D5PL04", "url": "https://www.orthodb.org/?gene=A0A1D5PL04", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0ZB62", "url": "https://www.orthodb.org/?gene=A0A8V0ZB62", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0ZB70", "url": "https://www.orthodb.org/?gene=A0A8V0ZB70", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0ZGV4", "url": "https://www.orthodb.org/?gene=A0A8V0ZGV4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF44", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF44", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_004944662", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004944662", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PL04-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZB62", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZB62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZB62-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZB62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZB70", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZB70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZB70-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZB70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZGV4", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZGV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZGV4-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZGV4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVDHLVPTDESFASTRSSLGYFRDMTAGVRSYQMLPSPLSEDDSDSSSFCSCSSPESQVLSSSYGSTSSAESQDSILDYLLSQASLGNTAASWWDKRRLQPIVKEEYFRLPEFAVDMEDSGPFQPTLEEIEEFLEENMELELKERPKSETKDLRACSQVSVASLQQKDHMLPNATLKESKNEQLSSSTEGGQASNGGVSLENGIPVMLQIQPVQIKQESSTSPSSQGPAQENIKIAQLLVNIQGQTFALVPQIVQSSNLNLPSKFVRIAPVPIAAKPIGPGGMIQGQTGIIMGQKFQKNPAAELIKMHKCSFPGCTKMYTKSSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHVKVHRFPRSSRSVRSVN", "length": 403, "header": "tr|A0A1D5PL04-1|A0A1D5PL04_CHICK Isoform 1 of Krueppel-like factor 15 OS=Gallus gallus OX=9031 GN=KLF15 PE=4 SV=3 CANONICAL=A0A1D5PL04-1" }, "isoforms": [ { "isoform_ac": "A0A1D5PL04-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04/entry#A0A1D5PL04-1", "sequence": { "sequence": "MVDHLVPTDESFASTRSSLGYFRDMTAGVRSYQMLPSPLSEDDSDSSSFCSCSSPESQVLSSSYGSTSSAESQDSILDYLLSQASLGNTAASWWDKRRLQPIVKEEYFRLPEFAVDMEDSGPFQPTLEEIEEFLEENMELELKERPKSETKDLRACSQVSVASLQQKDHMLPNATLKESKNEQLSSSTEGGQASNGGVSLENGIPVMLQIQPVQIKQESSTSPSSQGPAQENIKIAQLLVNIQGQTFALVPQIVQSSNLNLPSKFVRIAPVPIAAKPIGPGGMIQGQTGIIMGQKFQKNPAAELIKMHKCSFPGCTKMYTKSSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHVKVHRFPRSSRSVRSVN", "length": 403, "header": "tr|A0A1D5PL04-1|A0A1D5PL04_CHICK Isoform 1 of Krueppel-like factor 15 OS=Gallus gallus OX=9031 GN=KLF15 PE=4 SV=3 CANONICAL=A0A1D5PL04-1" }, "locus": { "chromosome": "12", "start_pos": 10815078, "end_pos": 10808747, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010051308.1", "url": "https://www.ensembl.org/id/ENSGALT00010051308.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010030499.1", "url": "https://www.ensembl.org/id/ENSGALP00010030499.1" } ] } }, { "isoform_ac": "A0A8V0ZB62-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04/entry#A0A8V0ZB62-1", "sequence": { "sequence": "MDISSQQLHTSGSSRAFCTLQPLCNSRIQPALHGAGRETERIWPREVKAAQKGSHLNLRCVVYAAGIPVGARPGMVDHLVPTDESFASTRSSLGYFRDMTAGVRSYQMLPSPLSEDDSDSSSFCSCSSPESQVLSSSYGSTSSAESQDSILDYLLSQASLGNTAASWWDKRRLQPIVKEEYFRLPEFAVDMEDSGPFQPTLEEIEEFLEENMELELKERPKSETKDLRACSQVSVASLQQKDHMLPNATLKESKNEQLSSSTEGGQASNGGVSLENGIPVMLQIQPVQIKQESSTSPSSQGPAQENIKIAQLLVNIQGQTFALVPQIVQSSNLNLPSKFVRIAPVPIAAKPIGPGGMIQGQTGIIMGQKFQKNPAAELIKMHKCSFPGCTKMYTKSSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHVKVHRFPRSSRSVRSVN", "length": 477, "header": "tr|A0A8V0ZB62-1|A0A8V0ZB62_CHICK Computationally mapped isoform of Krueppel-like factor 15 OS=Gallus gallus OX=9031 GN=KLF15 PE=4 SV=1 CANONICAL=A0A1D5PL04-1" }, "locus": { "chromosome": "12", "start_pos": 10821355, "end_pos": 10808747, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010051317.1", "url": "https://www.ensembl.org/id/ENSGALT00010051317.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010030507.1", "url": "https://www.ensembl.org/id/ENSGALP00010030507.1" } ] } }, { "isoform_ac": "A0A8V0ZB70-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04/entry#A0A8V0ZB70-1", "sequence": { "sequence": "MLSLLNDTCSPWVPLVCRKTHFSPQLRCRQMSPEVGALGSHLNLRCVVYAAGIPVGARPGMVDHLVPTDESFASTRSSLGYFRDMTAGVRSYQMLPSPLSEDDSDSSSFCSCSSPESQVLSSSYGSTSSAESQDSILDYLLSQASLGNTAASWWDKRRLQPIVKEEYFRLPEFAVDMEDSGPFQPTLEEIEEFLEENMELELKERPKSETKDLRACSQVSVASLQQKDHMLPNATLKESKNEQLSSSTEGGQASNGGVSLENGIPVMLQIQPVQIKQESSTSPSSQGPAQENIKIAQLLVNIQGQTFALVPQIVQSSNLNLPSKFVRIAPVPIAAKPIGPGGMIQGQTGIIMGQKFQKNPAAELIKMHKCSFPGCTKMYTKSSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHVKVHRFPRSSRSVRSVN", "length": 463, "header": "tr|A0A8V0ZB70-1|A0A8V0ZB70_CHICK Computationally mapped isoform of Krueppel-like factor 15 OS=Gallus gallus OX=9031 GN=KLF15 PE=4 SV=1 CANONICAL=A0A1D5PL04-1" }, "locus": { "chromosome": "12", "start_pos": 10831910, "end_pos": 10808747, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010051321.1", "url": "https://www.ensembl.org/id/ENSGALT00010051321.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010030512.1", "url": "https://www.ensembl.org/id/ENSGALP00010030512.1" } ] } }, { "isoform_ac": "A0A8V0ZGV4-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04/entry#A0A8V0ZGV4-1", "sequence": { "sequence": "MSSSLFWLFERSRGSHLNLRCVVYAAGIPVGARPGMVDHLVPTDESFASTRSSLGYFRDMTAGVRSYQMLPSPLSEDDSDSSSFCSCSSPESQVLSSSYGSTSSAESQDSILDYLLSQASLGNTAASWWDKRRLQPIVKEEYFRLPEFAVDMEDSGPFQPTLEEIEEFLEENMELELKERPKSETKDLRACSQVSVASLQQKDHMLPNATLKESKNEQLSSSTEGGQASNGGVSLENGIPVMLQIQPVQIKQESSTSPSSQGPAQENIKIAQLLVNIQGQTFALVPQIVQSSNLNLPSKFVRIAPVPIAAKPIGPGGMIQGQTGIIMGQKFQKNPAAELIKMHKCSFPGCTKMYTKSSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHVKVHRFPRSSRSVRSVN", "length": 438, "header": "tr|A0A8V0ZGV4-1|A0A8V0ZGV4_CHICK Computationally mapped isoform of Krueppel-like factor 15 OS=Gallus gallus OX=9031 GN=KLF15 PE=4 SV=1 CANONICAL=A0A1D5PL04-1" }, "locus": { "chromosome": "12", "start_pos": 10824330, "end_pos": 10808747, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010051318.1", "url": "https://www.ensembl.org/id/ENSGALT00010051318.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010030509.1", "url": "https://www.ensembl.org/id/ENSGALP00010030509.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "gga:427588", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:427588", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9UIH9-1", "protein_name": "Krueppel-like factor 15", "gene_name": "KLF15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVDHLLPVDENFSSPKCPVGYLGDRLVGRRAYHMLPSPVSEDDSDASSPCSCSSPDSQALCSCYGGGLGTESQDSILDFLLSQATLGSGGGSGSSIGASSGPVAWGPWRRAAAPVKGEHFCLPEFPLGDPDDVPRPFQPTLEEIEEFLEENMEPGVKEVPEGNSKDLDACSQLSAGPHKSHLHPGSSGRERCSPPPGGASAGGAQGPGGGPTPDGPIPVLLQIQPVPVKQESGTGPASPGQAPENVKVAQLLVNIQGQTFALVPQVVPSSNLNLPSKFVRIAPVPIAAKPVGSGPLGPGPAGLLMGQKFPKNPAAELIKMHKCTFPGCSKMYTKSSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHIKVHRFPRSSRSVRSVN", "length": 416 }, "evidence": [ { "id": "A0A1D5PL04", "url": "https://omabrowser.org/oma/group/A0A1D5PL04/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "pmid": "" }, { "name": "response to insulin", "id": "GO:0032868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "pmid": "" }, { "name": "intracellular glucose homeostasis", "id": "GO:0001678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001678", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "pmid": "" }, { "name": "regulation of Wnt signaling pathway", "id": "GO:0030111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030111", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "pmid": "" }, { "name": "cardiac muscle hypertrophy in response to stress", "id": "GO:0014898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014898", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "pmid": "" }, { "name": "positive regulation of D-glucose import", "id": "GO:0046326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046326", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "pmid": "" }, { "name": "glial cell differentiation", "id": "GO:0010001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010001", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "pmid": "" }, { "name": "podocyte differentiation", "id": "GO:0072112", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072112", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PL04", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PL04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 173, "end_pos": 175 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": 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