{ "uniprot_canonical_ac": "A0A1D5PI43-1", "uniprot_ac": "A0A1D5PI43", "uniprot_id": "A0A1D5PI43_CHICK", "mass": { "chemical_mass": 58575.0, "monoisotopic_mass": 58575.0 }, "refseq": { "ac": "XP_416766", "name": "amine oxidase [flavin-containing] B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_416766" }, "gene_names": [ { "name": "MAOB", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43", "id": "A0A1D5PI43" }, { "name": "MAOB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_416766", "id": "XP_416766" } ], "protein_names": [ { "name": "Amine oxidase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43/entry#names_and_taxonomy", "id": "A0A1D5PI43" }, { "name": "1.4.3.-", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43/entry#names_and_taxonomy", "id": "A0A1D5PI43" }, { "name": "amine oxidase [flavin-containing] B isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_416766", "id": "XP_416766" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_416766.1. COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_416766", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_416766" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "MAOB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43", "locus": {} } ], "crossref": [ { "id": "A0A1D5PI43", "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PI43", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000032836", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000032836", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "418561", "url": "https://www.ncbi.nlm.nih.gov/gene/418561", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001613", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001613", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050703", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050703", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "gga:418561", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:418561", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PIHWAGT", "url": "https://omabrowser.org/oma/group/PIHWAGT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1D5PI43", "url": "https://www.orthodb.org/?gene=A0A1D5PI43", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0YDQ2", "url": "https://www.orthodb.org/?gene=A0A8V0YDQ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0YDQ6", "url": "https://www.orthodb.org/?gene=A0A8V0YDQ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0YIE1", "url": "https://www.orthodb.org/?gene=A0A8V0YIE1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0YIE5", "url": "https://www.orthodb.org/?gene=A0A8V0YIE5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43563", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43563", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43563:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43563:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01593", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01593", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-141333", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-141333", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_416766", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_416766", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "26414", "url": "https://www.rhea-db.org/rhea/26414", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A1D5PI43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PI43-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YDQ2", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YDQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YDQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YDQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YDQ6", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YDQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YDQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YDQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YIE1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YIE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YIE1-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YIE1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YIE5", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YIE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YIE5-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YIE5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQKCDVVVVGGGISGLSAAKLLTEAGLNVVLLEANDRVGGRTFTVKNKQVKYVDLGGAYVGPTQNRLLRLSKELGIETYKVNEVEQLIHHVKGKSYPFKGAFPPLWNPLAYLDYNNLWRTMDEMGKEIPNEAPWKAPHAEEWDRMTMQDFIDKICWTKAAKSFATLFVNVDVTSEPHEVSALWFLWYVKQCGGTARIFSTTNGGQERKFVGGSGQISEKIMERLGGRVKLKKPVVRIDQSGENVVVETLDHELYEGKYVISAIPPVLCLKIHFNPPLPPMRNQLINRIPMGSVIKCIVYYKETFWRKKGYCGTMMIEDEDAAIGLTLDDTKPDGSFPAIIGFILARKCRRLTNLTKEERKTRLCELYAKVLGSEEALHPVHYEEKNWCEEQYSGGCYTAYFPPGVMTQYGRILRQPIGKIYFAGTETATEWSGYMEGAIQAGERAAREVLFAMKKIPDTEIWKPEPESIDVPALPITTTFWERNLPSVPGLLKLIGFSTFFTSVAAAGLFAYRKGLLVRN", "length": 521, "header": "tr|A0A1D5PI43-1|A0A1D5PI43_CHICK Isoform 1 of Amine oxidase OS=Gallus gallus OX=9031 GN=MAOB PE=1 SV=1 CANONICAL=A0A1D5PI43-1" }, "isoforms": [ { "isoform_ac": "A0A1D5PI43-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43/entry#A0A1D5PI43-1", "sequence": { "sequence": "MAQKCDVVVVGGGISGLSAAKLLTEAGLNVVLLEANDRVGGRTFTVKNKQVKYVDLGGAYVGPTQNRLLRLSKELGIETYKVNEVEQLIHHVKGKSYPFKGAFPPLWNPLAYLDYNNLWRTMDEMGKEIPNEAPWKAPHAEEWDRMTMQDFIDKICWTKAAKSFATLFVNVDVTSEPHEVSALWFLWYVKQCGGTARIFSTTNGGQERKFVGGSGQISEKIMERLGGRVKLKKPVVRIDQSGENVVVETLDHELYEGKYVISAIPPVLCLKIHFNPPLPPMRNQLINRIPMGSVIKCIVYYKETFWRKKGYCGTMMIEDEDAAIGLTLDDTKPDGSFPAIIGFILARKCRRLTNLTKEERKTRLCELYAKVLGSEEALHPVHYEEKNWCEEQYSGGCYTAYFPPGVMTQYGRILRQPIGKIYFAGTETATEWSGYMEGAIQAGERAAREVLFAMKKIPDTEIWKPEPESIDVPALPITTTFWERNLPSVPGLLKLIGFSTFFTSVAAAGLFAYRKGLLVRN", "length": 521, "header": "tr|A0A1D5PI43-1|A0A1D5PI43_CHICK Isoform 1 of Amine oxidase OS=Gallus gallus OX=9031 GN=MAOB PE=1 SV=1 CANONICAL=A0A1D5PI43-1" }, "locus": { "chromosome": "1", "start_pos": 111354699, "end_pos": 111305848, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010027607.1", "url": "https://www.ensembl.org/id/ENSGALT00010027607.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010015813.1", "url": "https://www.ensembl.org/id/ENSGALP00010015813.1" } ] } }, { "isoform_ac": "A0A8V0YDQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43/entry#A0A8V0YDQ2-1", "sequence": { "sequence": "MAQKCDVVVVGGGISGLSAAKLLTEAGLNVVLLEANDRVGGRTFTVKNKQVKYVDLGGAYVGPTQNRLLRLSKELGIETYKVNEVEQLIHHVKQSGRVKIMYCKSAK", "length": 107, "header": "tr|A0A8V0YDQ2-1|A0A1D5PI43_CHICK Computationally mapped isoform of Amine oxidase OS=Gallus gallus OX=9031 GN=MAOB PE=1 SV=1 CANONICAL=A0A1D5PI43-1" }, "locus": { "chromosome": "1", "start_pos": 111332021, "end_pos": 111305848, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010027602.1", "url": "https://www.ensembl.org/id/ENSGALT00010027602.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010015809.1", "url": "https://www.ensembl.org/id/ENSGALP00010015809.1" } ] } }, { "isoform_ac": "A0A8V0YDQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43/entry#A0A8V0YDQ6-1", "sequence": { "sequence": "MAQKCDVVVVGGGISGLSAAKLLTEAGLNVVLLEANDRVGGRTFTVKNKQVKYVDLGGAYVGPTQNRLLRLSKELGIETYKVNEVEQLIHHVKIPNEAPWKAPHAEEWDRMTMQDFIDKICWTKAAKSFATLFVNVDVTSEPHEVSALWFLWYVKQCGGTARIFSTTNGGQERKFVGGSGQISEKIMERLGGRVKLKKPVVRIDQSGENVVVETLDHELYEGKYVISAIPPVLCLKIHFNPPLPPMRNQLINRIPMGSVIKCIVYYKETFWRKKGYCGTMMIEDEDAAIGLTLDDTKPDGSFPAIIGFILARKCRRLTNLTKEERKTRLCELYAKVLGSEEALHPVHYEEKNWCEEQYSGGCYTAYFPPGVMTQYGRILRQPIGKIYFAGTETATEWSGYMEGAIQAGERAAREVLFAMKKIPDTEIWKPEPESIDVPALPITTTFWERNLPSVPGLLKLIGFSTFFTSVAAAGLFAYRKGLLVRN", "length": 486, "header": "tr|A0A8V0YDQ6-1|A0A1D5PI43_CHICK Computationally mapped isoform of Amine oxidase OS=Gallus gallus OX=9031 GN=MAOB PE=1 SV=1 CANONICAL=A0A1D5PI43-1" }, "locus": { "chromosome": "1", "start_pos": 111354699, "end_pos": 111305848, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010027609.1", "url": "https://www.ensembl.org/id/ENSGALT00010027609.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010015814.1", "url": "https://www.ensembl.org/id/ENSGALP00010015814.1" } ] } }, { "isoform_ac": "A0A8V0YIE1-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43/entry#A0A8V0YIE1-1", "sequence": { "sequence": "MAQKCDVVVVGGGISGLSAAKLLTEAGLNVVLLEANDRVGGRTFTVKNKQVKYVDLGGAYVGPTQNRLLRLSKELGIETYKVNEVEQLIHHVKTSRVRETATEVEVWALSKENLSVDHKCLNTWIARGRLGCKQPFAIICGHL", "length": 143, "header": "tr|A0A8V0YIE1-1|A0A8V0YIE1_CHICK Computationally mapped isoform of monoamine oxidase OS=Gallus gallus OX=9031 GN=MAOB PE=1 SV=1 CANONICAL=A0A1D5PI43-1" }, "locus": { "chromosome": "1", "start_pos": 111326524, "end_pos": 111305848, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010027599.1", "url": "https://www.ensembl.org/id/ENSGALT00010027599.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010015807.1", "url": "https://www.ensembl.org/id/ENSGALP00010015807.1" } ] } }, { "isoform_ac": "A0A8V0YIE5-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43/entry#A0A8V0YIE5-1", "sequence": { "sequence": "MGLSAAKLLTEAGLNVVLLEANDRVGGRTFTVKNKQVKYVDLGGAYVGPTQNRLLRLSKELGIETYKVNEVEQLIHHVKGKSYPFKGAFPPLWNPLAYLDYNNLWRTMDEMGKEIPNEAPWKAPHAEEWDRMTMQDFIDKICWTKAAKSFATLFVNVDVTSEPHEVSALWFLWYVKQCGGTARIFSTTNGGQERKFVGGSGQISEKIMERLGGRVKLKKPVVRIDQSGENVVVETLDHELYEGKYVISAIPPVLCLKIHFNPPLPPMRNQLINRIPMGSVIKCIVYYKETFWRKKGYCGTMMIEDEDAAIGLTLDDTKPDGSFPAIIGFILARKCRRLTNLTKEERKTRLCELYAKVLGSEEALHPVHYEEKNWCEEQYSGGCYTAYFPPGVMTQYGRILRQPIGKIYFAGTETATEWSGYMEGAIQAGERAAREVLFAMKKIPDTEIWKPEPESIDVPALPITTTFWERNLPSVPGLLKLIGFSTFFTSVAAAGLFAYRKGLLVRN", "length": 507, "header": "tr|A0A8V0YIE5-1|A0A8V0YIE5_CHICK Computationally mapped isoform of monoamine oxidase OS=Gallus gallus OX=9031 GN=MAOB PE=1 SV=1 CANONICAL=A0A1D5PI43-1" }, "locus": { "chromosome": "1", "start_pos": 111354699, "end_pos": 111323524, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010027606.1", "url": "https://www.ensembl.org/id/ENSGALT00010027606.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010015812.1", "url": "https://www.ensembl.org/id/ENSGALP00010015812.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "gga:418561", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:418561", "resource": "KEGG Pathway" }, { "id": "R-GGA-141333", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-141333", "resource": "Reactome", "description": "Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A140T837-1", "protein_name": "Amine oxidase", "gene_name": "MAOB", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSSKCDVVVVGGGISGMAAAKLLHDSGLNVIVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNHILRLSKELGLETYKVNEVERLIHHTKGKSYPFRGSFPSVWNPITYLDHNNLWRTMDDMGREIPSDAPWKAPLAEQWDLMTMKELLDKICWTESSKQLAILFVNLCVTAEIHEVSALWFLWYVKQCGGTTRIFSTSNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIHIDQTGENVLVETLNHELYEAKYVISAVPPVLGMKIHFNPPLPMMRNQLITRVPLGSVIKSIVYYKEPFWRNMDYCGSMIIEGEEAPVAYALDDTKPDGSYPAIIGFILAHKARKLARLTKEERLKKLCDLYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTSYFPPGIMTQYGRVLRQPVGRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWLPEPESVDVPAKPITTTFLQRHLPSVPGLLKLIGLTTIFSATALGYLAHKRGLLVRI", "length": 520 }, "evidence": [ { "id": "A0A1D5PI43", "url": "https://omabrowser.org/oma/group/A0A1D5PI43/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "P19643-1", "protein_name": "Amine oxidase [flavin-containing] B", "gene_name": "Maob", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF", "length": 520 }, "evidence": [ { "id": "A0A1D5PI43", "url": "https://omabrowser.org/oma/group/A0A1D5PI43/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P27338-1", "protein_name": "Amine oxidase [flavin-containing] B", "gene_name": "MAOB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV", "length": 520 }, "evidence": [ { "id": "A0A1D5PI43", "url": "https://omabrowser.org/oma/group/A0A1D5PI43/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54IT3-1", "protein_name": "Probable flavin-containing monoamine oxidase A", "gene_name": "maoA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSTLYDVVIVGGGLTGLNAAYQFKKAGLNVMVLKPKDRFGGRTESIKVEDYWFDLGGQWMGGTHKYLKELCDELGVKSFPQYDEGKHVLEINGKKVYYQGNISNLNKSYNLEGLFESISKIDELSAELNPDKPYAHSKSKEYDQLTVAQWVEKNVKGNDARSIIDWFCRVCVAAEPTEVSFLFFLHFIRTAGNYGLLADIHGGAQQDRLIGGSQQISEGLAKKIGEKHYTLNAPVRSIIQDANQCTIKTDNGSTYRSKYIVVAIPPTLAGRIHYSPSMPPRRDELTQRMPMGSVIKTITIYDEPFWRKEGYSAEAISDKGPIFICYDDSSHDDKKTAIVGFIAASAAKDWAEKSPEERKRAVLDCYARWWGPKALSPRIFLEKSWKEEEYSRGCYLGYTSPGTLYQCGEHLRAPVGRIHWAGTETASVWIGYMEGALESGFRVSKEIKDKLLNSKL", "length": 456 }, "evidence": [ { "id": "A0A1D5PI43", "url": "https://omabrowser.org/oma/group/A0A1D5PI43/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8BW75-1", "protein_name": "Amine oxidase [flavin-containing] B", "gene_name": "Maob", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNKSDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDNNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTKSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVIVKTLNHEIYEAKYVISAIPPALGMKIHYSPPLPMLRNQLISRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGTYAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESLDVPARPITSTFLERHLPSVPGLLKLFGLTTILSATALGFLAHKRGLFVHF", "length": 520 }, "evidence": [ { "id": "A0A1D5PI43", "url": "https://omabrowser.org/oma/group/A0A1D5PI43/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43" } ], "pmid": "" }, { "name": "primary methylamine oxidase activity", "id": "GO:0008131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008131", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43" } ], "pmid": "" }, { "name": "flavin adenine dinucleotide binding", "id": "GO:0050660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050660", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 354, "end_pos": 356, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "26414", "name": "", "equation": "a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PI43-1", "A0A8V0YBI7-1" ], "evidence": [ { "id": "26414", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/26414" } ] }, { "id": "R-GGA-141200", "name": "MAOB:FAD oxidatively deaminates of PEA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial outer membrane", "input_participant_list": [ "R-ALL-500605" ], "output_participant_list": [ "R-ALL-500607" ], "enzyme_list": [ "A0A1D5PI43-1" ], "evidence": [ { "id": "R-GGA-141200", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-141200" } ] }, { "id": "R-GGA-141202", "name": "MAOB:FAD oxidatively deaminates TYR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial outer membrane", "input_participant_list": [ "R-ALL-500606" ], "output_participant_list": [ "R-ALL-500608" ], "enzyme_list": [ "A0A1D5PI43-1" ], "evidence": [ { "id": "R-GGA-141202", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-141202" } ] }, { "id": "R-GGA-9677929", "name": "MAOB inhibitors bind MAOB:FAD", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial outer membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PI43-1" ], "evidence": [ { "id": "R-GGA-9677929", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-9677929" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-500605", "participant_name": "PEA [cytosol]", "crossref": [ { "id": "18397", "database": "ChEBI", "url": "" }, { "id": "C05332", "database": "COMPOUND", "url": "" }, { "id": "8144848", "database": "PubChem Substance", "url": "" }, { "id": "2144", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000006579654", "database": "ZINC", "url": "" }, { "id": "HMDB0012275", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-500606", "participant_name": "TYR [cytosol]", "crossref": [ { "id": "15760", "database": "ChEBI", "url": "" }, { "id": "8143353", "database": "PubChem Substance", "url": "" }, { "id": "C00483", "database": "COMPOUND", "url": "" }, { "id": "2150", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000000002233", "database": "ZINC", "url": "" }, { "id": "HMDB0000306", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-500607", "participant_name": "Phenylacetaldehyde [cytosol]", "crossref": [ { "id": "8143568", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0006236", "database": "HMDB Metabolite", "url": "" }, { "id": "16424", "database": "ChEBI", "url": "" }, { "id": "ZINC000000895323", "database": "ZINC", "url": "" }, { "id": "C00601", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-500608", "participant_name": "HPHAC [cytosol]", "crossref": [ { "id": "8143296", "database": "PubChem Substance", "url": "" }, { "id": "ZINC000000901834", "database": "ZINC", "url": "" }, { "id": "15621", "database": "ChEBI", "url": "" }, { "id": "HMDB0003767", "database": "HMDB Metabolite", "url": "" }, { "id": "C03765", "database": "COMPOUND", "url": "" }, { "id": "6635", "database": "Guide to Pharmacology - Ligands", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A1D5PI43", "gene_name": "MAOB", "activity": [ { "ec_number": "1.4.3.4", "activity": "a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2.", "evidence": [ { "id": "A0A1D5PI43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43" } ] }, { "ec_number": "1.4.3.4", "activity": "", "evidence": [ { "id": "A0A1D5PI43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43" } ] }, { "ec_number": "1.4.3.-", "activity": "", "evidence": [ { "id": "A0A1D5PI43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI43" } ] } ] }, { "uniprot_ac": "A0A8V0YBI7", "gene_name": "MAOA", "activity": [ { "ec_number": "1.4.3.-", "activity": "", "evidence": [ { "id": "A0A8V0YBI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YBI7" } ] }, { "ec_number": "1.4.3.4", "activity": "a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2.", "evidence": [ { "id": "A0A8V0YBI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YBI7" } ] }, { "ec_number": "1.4.3.4", "activity": "", "evidence": [ { "id": "A0A8V0YBI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YBI7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A1D5PI43-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 521, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A1D5PI43-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A1D5PI43" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.4.3.4", "ec_name": "a secondary aliphatic amine + O2 + H2O = a 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