{ "uniprot_canonical_ac": "A0A1D5PI23-1", "uniprot_ac": "A0A1D5PI23", "uniprot_id": "A0A1D5PI23_CHICK", "mass": { "chemical_mass": 20695.0, "monoisotopic_mass": 20695.0 }, "refseq": { "ac": "XP_015154951", "name": "dual specificity protein phosphatase 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015154951" }, "gene_names": [ { "name": "DUSP3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23", "id": "A0A1D5PI23" }, { "name": "DUSP3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015154951", "id": "XP_015154951" } ], "protein_names": [ { "name": "Dual specificity protein phosphatase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23/entry#names_and_taxonomy", "id": "A0A1D5PI23" }, { "name": "3.1.3.16", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23/entry#names_and_taxonomy", "id": "A0A1D5PI23" }, { "name": "3.1.3.48", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23/entry#names_and_taxonomy", "id": "A0A1D5PI23" }, { "name": "dual specificity protein phosphatase 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015154951", "id": "XP_015154951" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052558.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_015154951", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015154951" } ] }, { "annotation": "Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23#function" }, { "database": "UniProtKB", "id": "RU366038", "url": "https://www.uniprot.org/uniprotkb/RU366038#function" } ] }, { "annotation": "Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23#function" }, { "database": "UniProtKB", "id": "ARBA00056294", "url": "https://www.uniprot.org/uniprotkb/ARBA00056294#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "DUSP3", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23", "locus": {} } ], "crossref": [ { "id": "A0A1D5PI23", "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PI23", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000035369", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000035369", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14579", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14579", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "425527", "url": "https://www.ncbi.nlm.nih.gov/gene/425527", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020405", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020405", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "gga:425527", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:425527", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RHKMDVK", "url": "https://omabrowser.org/oma/group/RHKMDVK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1D5PI23", "url": "https://www.orthodb.org/?gene=A0A1D5PI23", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45682", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45682", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45682:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45682:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00782", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00782", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-202670", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-202670", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_015154951", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015154951", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10684", "url": "https://www.rhea-db.org/rhea/10684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "20629", "url": "https://www.rhea-db.org/rhea/20629", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47004", "url": "https://www.rhea-db.org/rhea/47004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PI23-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDYRISVEELNDLLANGSGCYSLPSAHSNEVVPRIHVGNAFIAKNIMKLQRLGITHVLNAAEGKSFMHVNTNAEFYEGTGITYHGIKANDTQEFNLSRYFEEAADFIEKALSQKDGQVFVHCREGYSRSPTLVIAYLMLRQNMDVKSALVTVRQKREIGPNDGFLRQLCQLNEQLVKEGKVKP", "length": 184, "header": "tr|A0A1D5PI23-1|A0A1D5PI23_CHICK Isoform 1 of Dual specificity protein phosphatase OS=Gallus gallus OX=9031 GN=DUSP3 PE=1 SV=1 CANONICAL=A0A1D5PI23-1" }, "isoforms": [ { "isoform_ac": "A0A1D5PI23-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23/entry#A0A1D5PI23-1", "sequence": { "sequence": "MSDYRISVEELNDLLANGSGCYSLPSAHSNEVVPRIHVGNAFIAKNIMKLQRLGITHVLNAAEGKSFMHVNTNAEFYEGTGITYHGIKANDTQEFNLSRYFEEAADFIEKALSQKDGQVFVHCREGYSRSPTLVIAYLMLRQNMDVKSALVTVRQKREIGPNDGFLRQLCQLNEQLVKEGKVKP", "length": 184, "header": "tr|A0A1D5PI23-1|A0A1D5PI23_CHICK Isoform 1 of Dual specificity protein phosphatase OS=Gallus gallus OX=9031 GN=DUSP3 PE=1 SV=1 CANONICAL=A0A1D5PI23-1" }, "locus": { "chromosome": "27", "start_pos": 3108134, "end_pos": 3102408, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010059213.1", "url": "https://www.ensembl.org/id/ENSGALT00010059213.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010036140.1", "url": "https://www.ensembl.org/id/ENSGALP00010036140.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "gga:425527", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:425527", "resource": "KEGG Pathway" }, { "id": "R-GGA-202670", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-202670", "resource": "Reactome", "description": "ERKs are inactivated" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480UG54-1", "protein_name": "Dual specificity protein phosphatase", "gene_name": "DUSP3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGPVELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFEKAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMLRQRMDVRSALSIVRQNREIGPNDGFLAQLCQLNDRLIKEGKLKR", "length": 185 }, "evidence": [ { "id": "A0A1D5PI23", "url": "https://omabrowser.org/oma/group/A0A1D5PI23/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6AF61-1", "protein_name": "Dual specificity protein phosphatase", "gene_name": "Dusp3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAMGCGTTQCLYALCYDDPIKGPAAAMSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVIPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYKDTGITYMGIKANDTQEFNLSAYFERAADFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMLRQKMDVRSALSTVRQNREIGPNDGFLAQLCQLNDRLAEEGKDPWN", "length": 212 }, "evidence": [ { "id": "A0A1D5PI23", "url": "https://omabrowser.org/oma/group/A0A1D5PI23/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A7YY43-1", "protein_name": "Dual specificity protein phosphatase", "gene_name": "DUSP3", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSGPFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFEKAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLVKEGKLKL", "length": 185 }, "evidence": [ { "id": "A0A1D5PI23", "url": "https://omabrowser.org/oma/group/A0A1D5PI23/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "E7EXY0-1", "protein_name": "Dual specificity protein phosphatase", "gene_name": "dusp3a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKKHHSPAKAPLEVTVTDTEATVQQLNKLLSDGSGFYSLPAQHFNEVFPRIYIGNAFVAQNVMRLQRLGVTHILNVAEGNSFMHVNTNAEFYAGTGITYHGIQANDTEQFNISAFFEEAADFIDKALAHGKGKVYVHCREGYSRSPTIVIAYLMLRHKMDVRVATATVRHKREIGPNGGFLCQLCQLNEKLAKEGKLKTK", "length": 200 }, "evidence": [ { "id": "A0A1D5PI23", "url": "https://omabrowser.org/oma/group/A0A1D5PI23/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P51452-1", "protein_name": "Dual specificity protein phosphatase 3", "gene_name": "DUSP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP", "length": 185 }, "evidence": [ { "id": "A0A1D5PI23", "url": "https://omabrowser.org/oma/group/A0A1D5PI23/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D7X3-1", "protein_name": "Dual specificity protein phosphatase 3", "gene_name": "Dusp3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSSFELSVQDLNDLLSDGSGCYSLPSQPCNEVVPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYEDSGITYLGIKANDTQEFNLSAYFERATDFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSTVRQNREIGPNDGFLAQLCQLNDRLAKEGKVKL", "length": 185 }, "evidence": [ { "id": "A0A1D5PI23", "url": "https://omabrowser.org/oma/group/A0A1D5PI23/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "regulation of focal adhesion assembly", "id": "GO:0051893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051893", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "positive regulation of mitotic cell cycle", "id": "GO:0045931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045931", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "negative regulation of ERK1 and ERK2 cascade", "id": "GO:0070373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070373", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "negative regulation of JNK cascade", "id": "GO:0046329", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046329", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "cellular response to epidermal growth factor stimulus", "id": "GO:0071364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071364", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "negative regulation of epidermal growth factor receptor signaling pathway", "id": "GO:0042059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042059", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "negative regulation of T cell receptor signaling pathway", "id": "GO:0050860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050860", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "negative regulation of T cell activation", "id": "GO:0050868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050868", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "axonemal microtubule doublet inner sheath", "id": "GO:0160110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160110", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "protein tyrosine/serine/threonine phosphatase activity", "id": "GO:0008138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008138", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "MAP kinase phosphatase activity", "id": "GO:0033549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033549", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PI23", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PI23-1", "F1P225-1", "A0A8V0XA98-1", "A0A8V0X7T6-1", "A0A8V0XI03-1", "A0A1D5P5S2-1", "A0A1D5PC43-1", "P0C597-1", "Q5F4B1-1", "Q6YI48-1", "Q90687-1", "Q98936-1", "Q9PW71-1", "A0A8V0YWD3-1", "A0A8V0Y719-1", "A0A8V0Z2T2-1", "A0A8V0Z920-1", "A0A8V0ZLS3-1", "A0A8V0YHN7-1", "Q5ZKG5-1", "Q9YH99-1", "Q9YHA0-1", "F1NCC5-1", "F1NAX3-1", "Q5F335-1", "A0A8V0XFP0-1", "A0A3Q2TZZ7-1", "A0A1D5NXI7-1", "Q7T2L9-1", "A0A8V0X4H3-1", "A0A8V0YAF3-1", "A0A8V0XYX4-1", "A0A8V0XVI4-1", "A0A8V0YFZ7-1", "A0A8V0YFC8-1", "A0A8V0YAP9-1", "A0A8V0YVP7-1", "A0A8V0YIN5-1", "A0A8V0ZMU4-1", "A0A8V0ZPJ8-1", "F1NVR5-1", "A0A8V0ZH43-1", "A0A8V0ZVC2-1", "A0A8V0ZQ53-1", "A0A1D5P6Q1-1", "A0A8V1A896-1", "A0A8V0ZVG8-1", "A0A8V1AB05-1", "A0A3Q2UCN1-1", "A0A8V1A4B8-1", "Q9YH98-1", "A0A8V0ZJ28-1", "F1NWE3-1", "O13016-1", "Q9W6V5-1", "E1BRQ8-1", "A0A1D5P6X3-1", "A0A8V0XAP8-1", "A0A1D5PMZ4-1", "F1N842-1", "A0A8V0YC26-1", "A0A8V0ZXB3-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] }, { "id": "20629", "name": "", "equation": "O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8V1AB34-1", "A0A1D5PI23-1", "A0A8V0ZW37-1", "P62207-1", "F1P225-1", "P0C597-1", "P48463-1", "Q9PTJ6-1", "Q9PW71-1", "A0A8V0Z2T2-1", "A0A8V0ZYK3-1", "Q5ZJJ8-1", "Q5ZJQ7-1", "Q9YHA0-1", "A0A1D5PJC6-1", "A0A8V0XTW9-1", "A0A8V0XLK8-1", "A0A8V0Y1D0-1", "A0A8V0ZMU4-1", "A0A8V0ZMX1-1", "A0A8V0ZQ53-1", "A0A8V0ZFN2-1", "A0A8V0ZPJ8-1", "A0A8V0ZWA8-1", "A0A8V1A8D0-1", "E1BTX9-1", "E1BRQ8-1", "A0A8V0ZJ28-1", "Q5ZIM8-1", "A0A8V0XYX4-1", "A0A8V0X9H5-1", "A0A8V0ZE41-1", "E1BYA9-1", "A0A8V0ZXB3-1", "Q7T2L9-1", "Q5F335-1", "F1NXH3-1", "F1NC58-1", "Q5ZL46-1", "A0A1D5P5S2-1", "A0A8V0ZA69-1", "F1N842-1", "A0A8V1A6D3-1", "A0A8V0ZND8-1", "A0A8V0ZS02-1", "A0A8V0YC26-1", "A0A8V1AKZ7-1", "A0A8V1AK42-1" ], "evidence": [ { "id": "20629", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20629" } ] }, { "id": "47004", "name": "", "equation": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5ZIV0-1", "A0A8V0Y3H9-1", "A0A1D5PI23-1", "P62207-1", "A0A8V0ZIN0-1", "F1P225-1", "E1BVM8-1", "A0A8V1ANF4-1", "A0A1D5P5S2-1", "P0C597-1", "P48463-1", "Q9PTJ6-1", "Q9PW71-1", "A0A8V0Z2T2-1", "A0A8V0ZYK3-1", "Q5ZJJ8-1", "Q5ZJQ7-1", "Q9YHA0-1", "F1NCC5-1", "Q5F335-1", "A0A8V0ZE41-1", "A0A1D5PJC6-1", "Q7T2L9-1", "E1BTX9-1", "A0A8V0XTW9-1", "A0A8V0XYX4-1", "A0A8V0XLK8-1", "A0A8V0Y1D0-1", "Q5ZM47-1", "A0A8V0Z256-1", "A0A8V0ZMU4-1", "A0A8V0ZMX1-1", "A0A8V0ZQ53-1", "A0A8V0ZPJ8-1", "A0A8V0ZWA8-1", "A0A8V0ZU36-1", "E1BRQ8-1", "A0A8V1A8D0-1", "A0A8V0ZJ28-1", "Q5ZIM8-1", "A0A8V0X9H5-1", "E1BYA9-1", "A0A8V0ZXB3-1", "A0A8V1AB34-1", "A0A8V0ZFN2-1", "F1NXH3-1", "Q5ZL46-1", "A0A8V0ZW37-1", "A0A8V0ZA69-1", "F1N842-1", "F1NJB8-1", "A0A8V1A6D3-1", "A0A8V0ZND8-1", "A0A8V0ZS02-1", "A0A8V0XYE1-1", "A0A8V0YC26-1", "A0A8V1AKZ7-1", "A0A8V1AK42-1" ], "evidence": [ { "id": "47004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47004" } ] }, { "id": "R-GGA-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PI23-1", "Q5F335-1", "F1NCC5-1" ], "evidence": [ { "id": "R-GGA-203797", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-203797" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A1D5NXI7", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5NXI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5NXI7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5NXI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5NXI7" } ] } ] }, { "uniprot_ac": "A0A1D5P5S2", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5P5S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P5S2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5P5S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P5S2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A1D5P5S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P5S2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5P5S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P5S2" } ] } ] }, { "uniprot_ac": "A0A1D5P6Q1", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5P6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P6Q1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5P6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P6Q1" } ] } ] }, { "uniprot_ac": "A0A1D5P6X3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5P6X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P6X3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5P6X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P6X3" } ] } ] }, { "uniprot_ac": "A0A1D5PC43", "gene_name": "EYA2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5PC43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5PC43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ] } ] }, { "uniprot_ac": "A0A1D5PI23", "gene_name": "DUSP3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5PI23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5PI23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5PI23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A1D5PI23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ] } ] }, { "uniprot_ac": "A0A1D5PJC6", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5PJC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PJC6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A1D5PJC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PJC6" } ] } ] }, { "uniprot_ac": "A0A1D5PMZ4", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5PMZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PMZ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5PMZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PMZ4" } ] } ] }, { "uniprot_ac": "A0A3Q2TZZ7", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q2TZZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q2TZZ7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q2TZZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q2TZZ7" } ] } ] }, { "uniprot_ac": "A0A3Q2UCN1", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q2UCN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q2UCN1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q2UCN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q2UCN1" } ] } ] }, { "uniprot_ac": "A0A8V0X4H3", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0X4H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X4H3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0X4H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X4H3" } ] } ] }, { "uniprot_ac": "A0A8V0X7T6", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0X7T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X7T6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0X7T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X7T6" } ] } ] }, { "uniprot_ac": "A0A8V0X9H5", "gene_name": "PPM1L", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0X9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X9H5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0X9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X9H5" } ] } ] }, { "uniprot_ac": "A0A8V0XA98", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XA98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XA98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0XA98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XA98" } ] } ] }, { "uniprot_ac": "A0A8V0XAP8", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XAP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XAP8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0XAP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XAP8" } ] } ] }, { "uniprot_ac": "A0A8V0XFP0", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XFP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XFP0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0XFP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XFP0" } ] } ] }, { "uniprot_ac": "A0A8V0XI03", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XI03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XI03" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0XI03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XI03" } ] } ] }, { "uniprot_ac": "A0A8V0XLK8", "gene_name": "PPEF2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XLK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XLK8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0XLK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XLK8" } ] } ] }, { "uniprot_ac": "A0A8V0XTW9", "gene_name": "PPP3CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XTW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XTW9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0XTW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XTW9" } ] } ] }, { "uniprot_ac": "A0A8V0XVI4", "gene_name": "LOC100858919", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XVI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XVI4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0XVI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XVI4" } ] } ] }, { "uniprot_ac": "A0A8V0XYE1", "gene_name": "PHLPP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XYE1", "database": "UniProtKB", "url": 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"uniprot_ac": "A0A8V0YAP9", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YAP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YAP9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YAP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YAP9" } ] } ] }, { "uniprot_ac": "A0A8V0YC26", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YC26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YC26" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YC26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YC26" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0YC26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YC26" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YC26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YC26" } ] } ] }, { "uniprot_ac": "A0A8V0YFC8", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YFC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YFC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YFC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YFC8" } ] } ] }, { "uniprot_ac": "A0A8V0YFZ7", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YFZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YFZ7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YFZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YFZ7" } ] } ] }, { "uniprot_ac": "A0A8V0YHN7", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YHN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YHN7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YHN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YHN7" } ] } ] }, { "uniprot_ac": "A0A8V0YIN5", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YIN5", "database": "UniProtKB", "url": 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"ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YWD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YWD3" } ] } ] }, { "uniprot_ac": "A0A8V0Z256", "gene_name": "CDKN3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0Z256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0Z256" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0Z256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0Z256" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0Z256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0Z256" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0Z256", "database": "UniProtKB", "url": 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"ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0Z920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0Z920" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0Z920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0Z920" } ] } ] }, { "uniprot_ac": "A0A8V0ZA69", "gene_name": "PGAM5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZA69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZA69" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZA69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZA69" } ] } ] }, { "uniprot_ac": "A0A8V0ZE41", "gene_name": "PPM1B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZE41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZE41" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZE41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZE41" } ] } ] }, { "uniprot_ac": "A0A8V0ZFN2", "gene_name": "CTDSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZFN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZFN2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZFN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZFN2" } ] } ] }, { "uniprot_ac": "A0A8V0ZH43", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = 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}, { "uniprot_ac": "A0A8V0ZND8", "gene_name": "PTPMT1", "activity": [ { "ec_number": "3.1.3.27", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.", "evidence": [ { "id": "A0A8V0ZND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZND8" } ] }, { "ec_number": "3.1.3.27", "activity": "", "evidence": [ { "id": "A0A8V0ZND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZND8" } ] } ] }, { "uniprot_ac": "A0A8V0ZPJ8", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZPJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZPJ8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZPJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZPJ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZPJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZPJ8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZPJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZPJ8" } ] } ] }, { "uniprot_ac": "A0A8V0ZQ53", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZQ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZQ53" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZQ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZQ53" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZQ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZQ53" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZQ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZQ53" } ] } ] }, { "uniprot_ac": "A0A8V0ZS02", "gene_name": "PPM1F", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZS02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZS02" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZS02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZS02" } ] } ] }, { "uniprot_ac": "A0A8V0ZU36", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZU36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZU36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZU36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZU36" } ] } ] }, { "uniprot_ac": "A0A8V0ZVC2", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZVC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZVC2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZVC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZVC2" } ] } ] }, { "uniprot_ac": "A0A8V0ZVG8", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZVG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZVG8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZVG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZVG8" } ] } ] }, { "uniprot_ac": "A0A8V0ZW37", "gene_name": "CDC14A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZW37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZW37" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZW37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZW37" } ] } ] }, { "uniprot_ac": "A0A8V0ZWA8", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZWA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZWA8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZWA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZWA8" } ] } ] }, { "uniprot_ac": "A0A8V0ZXB3", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZXB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZXB3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZXB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZXB3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZXB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZXB3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZXB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZXB3" } ] } ] }, { "uniprot_ac": "A0A8V0ZYK3", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZYK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZYK3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZYK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZYK3" } ] } ] }, { "uniprot_ac": "A0A8V1A4B8", "gene_name": "PTPRVP", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1A4B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A4B8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V1A4B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A4B8" } ] } ] }, { "uniprot_ac": "A0A8V1A6D3", "gene_name": "DUSP8", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1A6D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A6D3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1A6D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A6D3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V1A6D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A6D3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V1A6D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A6D3" } ] } ] }, { "uniprot_ac": "A0A8V1A896", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1A896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A896" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V1A896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A896" } ] } ] }, { "uniprot_ac": "A0A8V1A8D0", "gene_name": "PPTC7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1A8D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A8D0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V1A8D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A8D0" } ] } ] }, { "uniprot_ac": "A0A8V1AB05", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1AB05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AB05" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V1AB05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AB05" } ] } ] }, { "uniprot_ac": "A0A8V1AB34", "gene_name": "CTDSPL", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1AB34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AB34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V1AB34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AB34" } ] } ] }, { "uniprot_ac": "A0A8V1AK42", "gene_name": "DUSP23", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1AK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AK42" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1AK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AK42" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V1AK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AK42" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V1AK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AK42" } ] } ] }, { "uniprot_ac": "A0A8V1AKZ7", "gene_name": "PPM1E", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1AKZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AKZ7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V1AKZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AKZ7" } ] } ] }, { "uniprot_ac": "A0A8V1ANF4", "gene_name": "SSH2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1ANF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1ANF4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V1ANF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1ANF4" } ] } ] }, { "uniprot_ac": "E1BRQ8", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BRQ8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BRQ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BRQ8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BRQ8" } ] } ] }, { "uniprot_ac": "E1BTX9", "gene_name": "PPEF1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BTX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BTX9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BTX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BTX9" } ] } ] }, { "uniprot_ac": "E1BVM8", "gene_name": "PPM1A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BVM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BVM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BVM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BVM8" } ] } ] }, { "uniprot_ac": "E1BYA9", "gene_name": "ILKAP", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BYA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BYA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BYA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BYA9" } ] } ] }, { "uniprot_ac": "F1N842", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N842" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N842" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N842" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N842" } ] } ] }, { "uniprot_ac": "F1NAX3", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "F1NAX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NAX3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1NAX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NAX3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1NAX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NAX3" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "F1NAX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NAX3" } ] } ] }, { "uniprot_ac": "F1NC58", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "F1NC58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NC58" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1NC58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NC58" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "F1NC58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NC58" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1NC58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NC58" } ] } ] }, { "uniprot_ac": "F1NCC5", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1NCC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NCC5" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1NCC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NCC5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1NCC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NCC5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1NCC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NCC5" } ] } ] }, { "uniprot_ac": "F1NJB8", "gene_name": "PHLPP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1NJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NJB8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1NJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NJB8" } ] } ] }, { "uniprot_ac": "F1NVR5", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1NVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NVR5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1NVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NVR5" } ] } ] }, { "uniprot_ac": "F1NWE3", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1NWE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NWE3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1NWE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NWE3" } ] } ] }, { "uniprot_ac": "F1NXH3", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1NXH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NXH3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1NXH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NXH3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1NXH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NXH3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1NXH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NXH3" } ] } ] }, { "uniprot_ac": "F1P225", "gene_name": "LOC423731", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1P225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1P225" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1P225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1P225" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1P225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1P225" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1P225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1P225" } ] } ] }, { "uniprot_ac": "O13016", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O13016", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O13016" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O13016", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O13016" } ] } ] }, { "uniprot_ac": "P0C597", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C597" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C597" } ] } ] }, { "uniprot_ac": "P48463", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48463", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48463" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48463", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48463" } ] } ] }, { "uniprot_ac": "P62207", "gene_name": "PPP1CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P62207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62207" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P62207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62207" } ] }, { "ec_number": "3.1.3.53", "activity": "O-phospho-L-threonyl-[myosin light chain] + H2O = L-threonyl-[myosin light chain] + phosphate.", "evidence": [ { "id": "P62207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62207" } ] }, { "ec_number": "3.1.3.53", "activity": "", "evidence": [ { "id": "P62207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62207" } ] } ] }, { "uniprot_ac": "Q5F335", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5F335", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F335" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5F335", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F335" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5F335", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F335" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5F335", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F335" } ] } ] }, { "uniprot_ac": "Q5F4B1", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "Q5F4B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F4B1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5F4B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F4B1" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "Q5F4B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F4B1" } ] } ] }, { "uniprot_ac": "Q5ZIM8", "gene_name": "PPP3CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5ZIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZIM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5ZIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZIM8" } ] } ] }, { "uniprot_ac": "Q5ZIV0", "gene_name": "PPP6C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5ZIV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZIV0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5ZIV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZIV0" } ] } ] }, { "uniprot_ac": "Q5ZJJ8", "gene_name": "UBLCP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5ZJJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZJJ8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5ZJJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZJJ8" } ] } ] }, { "uniprot_ac": "Q5ZJQ7", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5ZJQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZJQ7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5ZJQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZJQ7" } ] } ] }, { "uniprot_ac": "Q5ZKG5", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "Q5ZKG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZKG5" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5ZKG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZKG5" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "Q5ZKG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZKG5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5ZKG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZKG5" } ] } ] }, { "uniprot_ac": "Q5ZL46", "gene_name": "EPM2A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5ZL46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZL46" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5ZL46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZL46" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5ZL46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZL46" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5ZL46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZL46" } ] } ] }, { "uniprot_ac": "Q5ZM47", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5ZM47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZM47" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5ZM47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZM47" } ] } ] }, { "uniprot_ac": "Q6YI48", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6YI48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6YI48" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6YI48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6YI48" } ] } ] }, { "uniprot_ac": "Q7T2L9", "gene_name": "MKP3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q7T2L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7T2L9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q7T2L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7T2L9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { 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