{ "uniprot_canonical_ac": "A0A1D5PC43-1", "uniprot_ac": "A0A1D5PC43", "uniprot_id": "A0A1D5PC43_CHICK", "mass": { "chemical_mass": 69994.0, "monoisotopic_mass": 69994.0 }, "refseq": {}, "gene_names": [ { "name": "EYA2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43", "id": "A0A1D5PC43" } ], "protein_names": [ { "name": "Eyes absent homolog", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43/entry#names_and_taxonomy", "id": "A0A1D5PC43" }, { "name": "3.1.3.48", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43/entry#names_and_taxonomy", "id": "A0A1D5PC43" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "EYA2", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43", "locus": { "chromosome": "20", "start_pos": 6104498, "end_pos": 6011009, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010023863", "url": "https://www.ensembl.org/id/ENSGALG00010023863" } ] } } ], "crossref": [ { "id": "A0A1D5PC43", "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PC43", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000004508", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000004508", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02601", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02601", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "395745", "url": "https://www.ncbi.nlm.nih.gov/gene/395745", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038102", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038102", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "XPNCVNV", "url": "https://omabrowser.org/oma/group/XPNCVNV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0ZPI4", "url": "https://www.orthodb.org/?gene=A0A8V0ZPI4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8V0ZYE4", "url": "https://www.orthodb.org/?gene=A0A8V0ZYE4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10190", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10190", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10190:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10190:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00702", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00702", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-5693565", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "10684", "url": "https://www.rhea-db.org/rhea/10684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PC43-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZPG9", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZPG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZPG9-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZPG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZPI4", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZPI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZPI4-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZPI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZWS4", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZWS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZWS4-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZWS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZYE4", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZYE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0ZYE4-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZYE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V1A282", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A282", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V1A282-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A282-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V1A290", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A290", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V1A290-1", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A290-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGLQLVQTLNSTPFMFLWLFHSSSWDLPFLRKGLGVIKAVRARTGGSRPLSSQNRRAAACPELLERGEERERVGHRSKTPRCHRGQAASPASRYKEMLDLVISPSLTVNKECPDRLKLNLTNIYATAPDDIEGNSKAAPQCPLHLYSTKHYPHIVTVQSFPTMATYGQTQYSAGIQQAAAYTAYPPPAQPYGIPSYSIKTEDSLSHSPGQSGFLSYGSSFSTPTAGQAPYTYQMHGTTGIYQGANGLTNSAGFSAVHQEYSSYPSFPQSQYSQYYSSSYNSPYMSTNSISPSAIPTSTYSLQESSHNITSQSTESLSGEYGTTPAKDIETDRHHRGSDGKVRARSKRSNDPSPTADSEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHIDDVSSDDNGQDLSTYNFSADGFHSSAASANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHALKALNLIHSRPNCVNVLVTTTQLIPALAKVLLYGLGTVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 631, "header": "tr|A0A1D5PC43-1|A0A1D5PC43_CHICK Isoform 1 of Eyes absent homolog OS=Gallus gallus OX=9031 GN=EYA2 PE=3 SV=2 CANONICAL=A0A1D5PC43-1" }, "isoforms": [ { "isoform_ac": "A0A1D5PC43-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43/entry#A0A1D5PC43-1", "sequence": { "sequence": "MSGLQLVQTLNSTPFMFLWLFHSSSWDLPFLRKGLGVIKAVRARTGGSRPLSSQNRRAAACPELLERGEERERVGHRSKTPRCHRGQAASPASRYKEMLDLVISPSLTVNKECPDRLKLNLTNIYATAPDDIEGNSKAAPQCPLHLYSTKHYPHIVTVQSFPTMATYGQTQYSAGIQQAAAYTAYPPPAQPYGIPSYSIKTEDSLSHSPGQSGFLSYGSSFSTPTAGQAPYTYQMHGTTGIYQGANGLTNSAGFSAVHQEYSSYPSFPQSQYSQYYSSSYNSPYMSTNSISPSAIPTSTYSLQESSHNITSQSTESLSGEYGTTPAKDIETDRHHRGSDGKVRARSKRSNDPSPTADSEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHIDDVSSDDNGQDLSTYNFSADGFHSSAASANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHALKALNLIHSRPNCVNVLVTTTQLIPALAKVLLYGLGTVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 631, "header": "tr|A0A1D5PC43-1|A0A1D5PC43_CHICK Isoform 1 of Eyes absent homolog OS=Gallus gallus OX=9031 GN=EYA2 PE=3 SV=2 CANONICAL=A0A1D5PC43-1" }, "locus": { "chromosome": "20", "start_pos": 6103705, "end_pos": 6011167, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010058196.1", "url": "https://www.ensembl.org/id/ENSGALT00010058196.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010035351.1", "url": "https://www.ensembl.org/id/ENSGALP00010035351.1" } ] } }, { "isoform_ac": "A0A8V0ZPG9-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43/entry#A0A8V0ZPG9-1", "sequence": { "sequence": "MRYKEMLDLVISPSLTVNKECPDRLKLNLTNIYATAPDDIEGNSKAAPQCPLHLYSTKHYPHIVTVQSFPTMATYGQTQYSAGIQQAAAYTAYPPPAQPYGIPSYSIKTEDSLSHSPGQSGFLSYGSSFSTPTAGQAPYTYQMHGTTGIYQGANGLTNSAGFSAVHQEYSSYPSFPQSQYSQYYSSSYNSPYMSTNSISPSAIPTSTYSLQESSHNITSQSTESLSGEYGTTPAKDIETDRHHRGSDGKVRARSKRSNDPSPTADSEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHIDDVSSDDNGQDLSTYNFSADGFHSSAASANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHALKALNLIHSRPNCVNVLVTTTQLIPALAKVLLYGLGTVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 539, "header": "tr|A0A8V0ZPG9-1|A0A1D5PC43_CHICK Computationally mapped isoform of Eyes absent homolog OS=Gallus gallus OX=9031 GN=EYA2 PE=3 SV=1 CANONICAL=A0A1D5PC43-1" }, "locus": { "chromosome": "20", "start_pos": 6103705, "end_pos": 6042447, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010058159.1", "url": "https://www.ensembl.org/id/ENSGALT00010058159.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010035318.1", "url": "https://www.ensembl.org/id/ENSGALP00010035318.1" } ] } }, { "isoform_ac": "A0A8V0ZPI4-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43/entry#A0A8V0ZPI4-1", "sequence": { "sequence": "MRACLAHAHCARGGRAHSAALRLRYKEMLDLVISPSLTVNKECPDRLKLNLTNIYATAPDDIEGNSKAAPQCPLHLYSTKHYPHIVTVQSFPTMATYGQTQYSAGIQQAAAYTAYPPPAQPYGIPSYSIKTEDSLSHSPGQSGFLSYGSSFSTPTAGQAPYTYQMHGTTGIYQGANGLTNSAGFSAVHQEYSSYPSFPQSQYSQYYSSSYNSPYMSTNSISPSAIPTSTYSLQESSHNITSQSTESLSGEYGTTPAKDIETDRHHRGSDGKVRARSKRSNDPSPTADSEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHIDDVSSDDNGQDLSTYNFSADGFHSSAASANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHALKALNLIHSRPNCVNVLVTTTQLIPALAKVLLYGLGTVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 561, "header": "tr|A0A8V0ZPI4-1|A0A8V0ZPI4_CHICK Computationally mapped isoform of Eyes absent homolog OS=Gallus gallus OX=9031 GN=EYA2 PE=3 SV=1 CANONICAL=A0A1D5PC43-1" }, "locus": { "chromosome": "20", "start_pos": 6103705, "end_pos": 6012415, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010058175.1", "url": "https://www.ensembl.org/id/ENSGALT00010058175.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010035333.1", "url": "https://www.ensembl.org/id/ENSGALP00010035333.1" } ] } }, { "isoform_ac": "A0A8V0ZWS4-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43/entry#A0A8V0ZWS4-1", "sequence": { "sequence": "MFNKHPALIRYKEMLDLVISPSLTVNKECPDRLKLNLTNIYATAPDDIEGNSKAAPQCPLHLYSTKHYPHIVTVQSFPTMATYGQTQYSAGIQQAAAYTAYPPPAQPYGIPSYSIKTEDSLSHSPGQSGFLSYGSSFSTPTAGQAPYTYQMHGTTGIYQGANGLTNSAGFSAVHQEYSSYPSFPQSQYSQYYSSSYNSPYMSTNSISPSAIPTSTYSLQESSHNITSQSTESLSGEYGTTPAKDIETDRHHRGSDGKVRARSKRSNDPSPTADSEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHIDDVSSDDNGQDLSTYNFSADGFHSSAASANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHALKALNLIHSRPNCVNVLVTTTQLIPALAKVLLYGLGTVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 547, "header": "tr|A0A8V0ZWS4-1|A0A8V0ZWS4_CHICK Computationally mapped isoform of Eyes absent homolog OS=Gallus gallus OX=9031 GN=EYA2 PE=3 SV=1 CANONICAL=A0A1D5PC43-1" }, "locus": { "chromosome": "20", "start_pos": 6103705, "end_pos": 6015203, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010058168.1", "url": "https://www.ensembl.org/id/ENSGALT00010058168.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010035327.1", "url": "https://www.ensembl.org/id/ENSGALP00010035327.1" } ] } }, { "isoform_ac": "A0A8V0ZYE4-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43/entry#A0A8V0ZYE4-1", "sequence": { "sequence": "MLDLVISPSLTVNKECPDRLKLNLTNIYATAPDDIEGKSKQSFHSKYEVESGNSKAAPQCPLHLYSTKHYPHIVTVQSFPTMATYGQTQYSAGIQQAAAYTAYPPPAQPYGIPSYSIKTEDSLSHSPGQSGFLSYGSSFSTPTAGQAPYTYQMHGTTGIYQGANGLTNSAGFSAVHQEYSSYPSFPQSQYSQYYSSSYNSPYMSTNSISPSAIPTSTYSLQESSHNITSQSTESLSGEYGTTPAKDIETDRHHRGSDGKVRARSKRSNDPSPTADSEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHIDDVSSDDNGQDLSTYNFSADGFHSSAASANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHALKALNLIHSRPNCVNVLVTTTQLIPALAKVLLYGLGTVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 549, "header": "tr|A0A8V0ZYE4-1|A0A8V0ZYE4_CHICK Computationally mapped isoform of Eyes absent homolog OS=Gallus gallus OX=9031 GN=EYA2 PE=3 SV=1 CANONICAL=A0A1D5PC43-1" }, "locus": { "chromosome": "20", "start_pos": 6103705, "end_pos": 6049545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010058190.1", "url": "https://www.ensembl.org/id/ENSGALT00010058190.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010035346.1", "url": "https://www.ensembl.org/id/ENSGALP00010035346.1" } ] } }, { "isoform_ac": "A0A8V1A282-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43/entry#A0A8V1A282-1", "sequence": { "sequence": "MLDLVISPSLTVNKECPDRLKLNLTNIYATAPDDIEGNSKAAPQCPLHLYSTKHYPHIVTVQSFPTMATYGQTQYSAGIQQAAAYTAYPPPAQPYGIPSYSIKTEDSLSHSPGQSGFLSYGSSFSTPTAGQAPYTYQMHGTTGIYQGANGLTNSAGFSAVHQEYSSYPSFPQSQYSQYYSSSYNSPYMSTNSISPSAIPTSTYSLQESSHNITSQSTESLSGEYGTTPAKDIETDRHHRGSDGKVRARSKRSNDPSPTADSEIERVFVWDLDETIIIFHSLLTGTFASRYGKDCDQIHIDDVSSDDNGQDLSTYNFSADGFHSSAASANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHALKALNLIHSRPNCVNVLVTTTQLIPALAKVLLYGLGTVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 504, "header": "tr|A0A8V1A282-1|A0A8V1A282_CHICK Computationally mapped isoform of Eyes absent homolog OS=Gallus gallus OX=9031 GN=EYA2 PE=3 SV=1 CANONICAL=A0A1D5PC43-1" }, "locus": { "chromosome": "20", "start_pos": 6103705, "end_pos": 6049545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010058183.1", "url": "https://www.ensembl.org/id/ENSGALT00010058183.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010035339.1", "url": "https://www.ensembl.org/id/ENSGALP00010035339.1" } ] } }, { "isoform_ac": "A0A8V1A290-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43/entry#A0A8V1A290-1", "sequence": { "sequence": "MLDLVISPSLTVNKECPDRLKLNLTNIYATAPDDIEVTVQSFPTMATYGQTQYSAGIQQAAAYTAYPPPAQPYGIPSYSIKTEDSLSHSPGQSGFLSYGSSFSTPTAGQAPYTYQMHGTTGIYQGANGLTNSAGFSAVHQEYSSYPSFPQSQYSQYYSSSYNSPYMSTNSISPSAIPTSTYSLQESSHNITSQSTESLSGEYGTTPAKDIETDRHHRGSDGKVRARSKRSNDPSPTADSEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHIDDVSSDDNGQDLSTYNFSADGFHSSAASANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHALKALNLIHSRPNCVNVLVTTTQLIPALAKVLLYGLGTVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 512, "header": "tr|A0A8V1A290-1|A0A8V1A290_CHICK Computationally mapped isoform of Eyes absent homolog OS=Gallus gallus OX=9031 GN=EYA2 PE=3 SV=1 CANONICAL=A0A1D5PC43-1" }, "locus": { "chromosome": "20", "start_pos": 6103705, "end_pos": 6049545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010058194.1", "url": "https://www.ensembl.org/id/ENSGALT00010058194.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010035349.1", "url": "https://www.ensembl.org/id/ENSGALP00010035349.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-GGA-5693565", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-5693565", "resource": "Reactome", "description": "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K1T5-1", "protein_name": "Eyes absent homolog", "gene_name": "Eya2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLEVVISPSLAASSDWGEHGAAVGALTDREGTAKAASLSVPQLFAKSHPRVPPGQSSAAMAAYGQTQYSTGIQQTPPYTAYPPPAQAYGIPPYSIKTEDSLNHSPSQSGFLSYGPSFSTAPAGQSPYTYPVHSECTAGLYQGANGLTNTAGFGSVHQDYPSYPNFPQNQYPQYFSPSYNPPYVPASSLCSSPLSTSTYVLQEAPHNVSQSSESLAGDYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSTDGFHSTAPGASLCLGTGVHGGVDWMRKLAFRYRRVKEMYNTYRNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 533 }, "evidence": [ { "id": "A0A1D5PC43", "url": "https://omabrowser.org/oma/group/A0A1D5PC43/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SBF5-1", "protein_name": "Eyes absent homolog", "gene_name": "EYA2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLELVISPSLTVNSDRPGKVKLNCAEADVWTLSDIEGISTSAAPSVSPLFARPCPRVLPSQPPTAMAAYGQTQYSAGIQQATPYTTYPPPGQAYGIPSYSIKTEDSLNHSPSQSGFLSYSTSFSTPPTGQSPYTYQMHGTAGIYQGANGLTNAAGFGSVHQDYPSYPGFPQSQYSQYYSSSYNPPYVPASSICSSPLSTSTYVLQEASHSVPNQSSESLGGEYNTHNGPSTPAKEGDPDRPPRASDGKLRGRSKRSSDPSPAADNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFSLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 538 }, "evidence": [ { "id": "A0A1D5PC43", "url": "https://omabrowser.org/oma/group/A0A1D5PC43/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O00167-1", "protein_name": "Protein phosphatase EYA2", "gene_name": "EYA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPGFPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 538 }, "evidence": [ { "id": "A0A1D5PC43", "url": "https://omabrowser.org/oma/group/A0A1D5PC43/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O08575-1", "protein_name": "Protein phosphatase EYA2", "gene_name": "Eya2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLEVVTSPSLATSSDWSEHGAAVGTLSDREGIAKSAALSVPQLFVKSHPRVPPGQSSTAMAAYGQTQYSTGIQQAPPYTAYPTPAQAYGIPPYSIKTEDSLNHSPSQSGFLSYGPSFSTAPAGQSPYTYPVHSTAGLYQGANGLTNTAGFGSVHQDYPSYPSFSQNQYPQYFSPSYNPPYVPASSLCSSPLSTSTYVLQEAPHNVPSQSSESLAGDYNTHNGPSTPAKEGDTERPHRASDGKLRGRSKRNSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSTDGFHSTAPGASLCLGTGVHGGVDWMRKLAFRYRRVKEMYNTYRNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 532 }, "evidence": [ { "id": "A0A1D5PC43", "url": "https://omabrowser.org/oma/group/A0A1D5PC43/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q58DB6-1", "protein_name": "Protein phosphatase EYA2", "gene_name": "EYA2", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MLELLVSASLTVNSDRPGKLKPSRADADVWTLSDREGITTSARSVSQLFARPCPRVPPGQPPSAMAAYSQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTPASGQSPYTYQMHGTAGIYQGANGLTNAAGFGTVHQDYPSYPGFPQSQYSQYYSSSYNPPYVPASSICPSPLSTSTYVLQEASHNIPSQSSESLGGEYNTHNGPSTPAKEGDTDRPPRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTASVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 537 }, "evidence": [ { "id": "A0A1D5PC43", "url": "https://omabrowser.org/oma/group/A0A1D5PC43/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "pmid": "" }, { "name": "histone H2AXY142 phosphatase activity", "id": "GO:0140793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140793", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "striated muscle tissue development", "id": "GO:0014706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014706", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "pmid": "" }, { "name": "positive regulation of DNA repair", "id": "GO:0045739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045739", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "pmid": "" }, { "name": "negative regulation of extrinsic apoptotic signaling pathway in absence of ligand", "id": "GO:2001240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001240", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "pmid": "" }, { "name": "extrinsic apoptotic signaling pathway in absence of ligand", "id": "GO:0097192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097192", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "pmid": "" }, { "name": "mitochondrial outer membrane permeabilization", "id": "GO:0097345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097345", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PC43", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" }, { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 442, "end_pos": 444, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PI23-1", "F1P225-1", "A0A8V0XA98-1", "A0A8V0X7T6-1", "A0A8V0XI03-1", "A0A1D5P5S2-1", "A0A1D5PC43-1", "P0C597-1", "Q5F4B1-1", "Q6YI48-1", "Q90687-1", "Q98936-1", "Q9PW71-1", "A0A8V0YWD3-1", "A0A8V0Y719-1", "A0A8V0Z2T2-1", "A0A8V0Z920-1", "A0A8V0ZLS3-1", "A0A8V0YHN7-1", "Q5ZKG5-1", "Q9YH99-1", "Q9YHA0-1", "F1NCC5-1", "F1NAX3-1", "Q5F335-1", "A0A8V0XFP0-1", "A0A3Q2TZZ7-1", "A0A1D5NXI7-1", "Q7T2L9-1", "A0A8V0X4H3-1", "A0A8V0YAF3-1", "A0A8V0XYX4-1", "A0A8V0XVI4-1", "A0A8V0YFZ7-1", "A0A8V0YFC8-1", "A0A8V0YAP9-1", "A0A8V0YVP7-1", "A0A8V0YIN5-1", "A0A8V0ZMU4-1", "A0A8V0ZPJ8-1", "F1NVR5-1", "A0A8V0ZH43-1", "A0A8V0ZVC2-1", "A0A8V0ZQ53-1", "A0A1D5P6Q1-1", "A0A8V1A896-1", "A0A8V0ZVG8-1", "A0A8V1AB05-1", "A0A3Q2UCN1-1", "A0A8V1A4B8-1", "Q9YH98-1", "A0A8V0ZJ28-1", "F1NWE3-1", "O13016-1", "Q9W6V5-1", "E1BRQ8-1", "A0A1D5P6X3-1", "A0A8V0XAP8-1", "A0A1D5PMZ4-1", "F1N842-1", "A0A8V0YC26-1", "A0A8V0ZXB3-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] }, { "id": "R-GGA-5683964", "name": "ATM phosphorylates EYA1-4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PC43-1", "A0A1D5NXI7-1", "A0A8V0XFP0-1" ], "evidence": [ { "id": "R-GGA-5683964", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-5683964" } ] }, { "id": "R-GGA-5683967", "name": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PC43-1", "A0A1D5NXI7-1", "A0A8V0XFP0-1" ], "evidence": [ { "id": "R-GGA-5683967", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-5683967" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A1D5NXI7", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5NXI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5NXI7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5NXI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5NXI7" } ] } ] }, { "uniprot_ac": "A0A1D5P5S2", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5P5S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P5S2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5P5S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P5S2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A1D5P5S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P5S2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5P5S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P5S2" } ] } ] }, { "uniprot_ac": "A0A1D5P6Q1", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5P6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P6Q1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5P6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P6Q1" } ] } ] }, { "uniprot_ac": "A0A1D5P6X3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5P6X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P6X3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5P6X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5P6X3" } ] } ] }, { "uniprot_ac": "A0A1D5PC43", "gene_name": "EYA2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5PC43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5PC43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PC43" } ] } ] }, { "uniprot_ac": "A0A1D5PI23", "gene_name": "DUSP3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5PI23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5PI23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5PI23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A1D5PI23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PI23" } ] } ] }, { "uniprot_ac": "A0A1D5PMZ4", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1D5PMZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PMZ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A1D5PMZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PMZ4" } ] } ] }, { "uniprot_ac": "A0A3Q2TZZ7", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q2TZZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q2TZZ7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q2TZZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q2TZZ7" } ] } ] }, { "uniprot_ac": "A0A3Q2UCN1", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q2UCN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q2UCN1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q2UCN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q2UCN1" } ] } ] }, { "uniprot_ac": "A0A8V0X4H3", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0X4H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X4H3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0X4H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X4H3" } ] } ] }, { "uniprot_ac": "A0A8V0X7T6", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0X7T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X7T6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0X7T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0X7T6" } ] } ] }, { "uniprot_ac": "A0A8V0XA98", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XA98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XA98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0XA98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XA98" } ] } ] }, { "uniprot_ac": "A0A8V0XAP8", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XAP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XAP8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0XAP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XAP8" } ] } ] }, { "uniprot_ac": "A0A8V0XFP0", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XFP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XFP0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0XFP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XFP0" } ] } ] }, { "uniprot_ac": "A0A8V0XI03", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XI03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XI03" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0XI03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XI03" } ] } ] }, { "uniprot_ac": "A0A8V0XVI4", "gene_name": "LOC100858919", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XVI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XVI4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0XVI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XVI4" } ] } ] }, { "uniprot_ac": "A0A8V0XYX4", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XYX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XYX4" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0XYX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XYX4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0XYX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XYX4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0XYX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0XYX4" } ] } ] }, { "uniprot_ac": "A0A8V0Y719", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0Y719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0Y719" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0Y719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0Y719" } ] } ] }, { "uniprot_ac": "A0A8V0YAF3", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YAF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YAF3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YAF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YAF3" } ] } ] }, { "uniprot_ac": "A0A8V0YAP9", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YAP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YAP9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YAP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YAP9" } ] } ] }, { "uniprot_ac": "A0A8V0YC26", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YC26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YC26" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YC26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YC26" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0YC26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YC26" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YC26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YC26" } ] } ] }, { "uniprot_ac": "A0A8V0YFC8", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YFC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YFC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YFC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YFC8" } ] } ] }, { "uniprot_ac": "A0A8V0YFZ7", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YFZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YFZ7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YFZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YFZ7" } ] } ] }, { "uniprot_ac": "A0A8V0YHN7", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YHN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YHN7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YHN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YHN7" } ] } ] }, { "uniprot_ac": "A0A8V0YIN5", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YIN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YIN5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YIN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YIN5" } ] } ] }, { "uniprot_ac": "A0A8V0YVP7", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YVP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YVP7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YVP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YVP7" } ] } ] }, { "uniprot_ac": "A0A8V0YWD3", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0YWD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YWD3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0YWD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0YWD3" } ] } ] }, { "uniprot_ac": "A0A8V0Z2T2", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0Z2T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0Z2T2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0Z2T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0Z2T2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0Z2T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0Z2T2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0Z2T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0Z2T2" } ] } ] }, { "uniprot_ac": "A0A8V0Z920", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0Z920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0Z920" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0Z920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0Z920" } ] } ] }, { "uniprot_ac": "A0A8V0ZH43", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZH43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZH43" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZH43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZH43" } ] } ] }, { "uniprot_ac": "A0A8V0ZJ28", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0A8V0ZJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZJ28" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZJ28" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZJ28" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZJ28" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0A8V0ZJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZJ28" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZJ28" } ] } ] }, { "uniprot_ac": "A0A8V0ZLS3", "gene_name": "LOC419429", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZLS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZLS3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZLS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZLS3" } ] } ] }, { "uniprot_ac": "A0A8V0ZMU4", "gene_name": "DUSP13", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZMU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZMU4" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZMU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZMU4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZMU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZMU4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZMU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZMU4" } ] } ] }, { "uniprot_ac": "A0A8V0ZPJ8", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZPJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZPJ8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZPJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZPJ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZPJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZPJ8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZPJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZPJ8" } ] } ] }, { "uniprot_ac": "A0A8V0ZQ53", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZQ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZQ53" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZQ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZQ53" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZQ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZQ53" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZQ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZQ53" } ] } ] }, { "uniprot_ac": "A0A8V0ZVC2", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZVC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZVC2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZVC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZVC2" } ] } ] }, { "uniprot_ac": "A0A8V0ZVG8", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZVG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZVG8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZVG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZVG8" } ] } ] }, { "uniprot_ac": "A0A8V0ZXB3", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZXB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZXB3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V0ZXB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZXB3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8V0ZXB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZXB3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V0ZXB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V0ZXB3" } ] } ] }, { "uniprot_ac": "A0A8V1A4B8", "gene_name": "PTPRVP", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1A4B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A4B8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V1A4B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A4B8" } ] } ] }, { "uniprot_ac": "A0A8V1A896", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1A896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A896" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V1A896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1A896" } ] } ] }, { "uniprot_ac": "A0A8V1AB05", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8V1AB05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AB05" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8V1AB05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8V1AB05" } ] } ] }, { "uniprot_ac": "E1BRQ8", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BRQ8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BRQ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BRQ8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BRQ8" } ] } ] }, { "uniprot_ac": "F1N842", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N842" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N842" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N842" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N842" } ] } ] }, { "uniprot_ac": "F1NAX3", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "F1NAX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NAX3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1NAX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NAX3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1NAX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NAX3" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "F1NAX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NAX3" } ] } ] }, { "uniprot_ac": "F1NCC5", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1NCC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NCC5" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1NCC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NCC5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1NCC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NCC5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1NCC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NCC5" } ] } ] }, { "uniprot_ac": "F1NVR5", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1NVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NVR5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1NVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NVR5" } ] } ] }, { "uniprot_ac": "F1NWE3", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1NWE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NWE3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1NWE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1NWE3" } ] } ] }, { "uniprot_ac": "F1P225", "gene_name": "LOC423731", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1P225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1P225" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1P225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1P225" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1P225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1P225" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1P225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1P225" } ] } ] }, { "uniprot_ac": "O13016", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O13016", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O13016" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O13016", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O13016" } ] } ] }, { "uniprot_ac": "P0C597", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C597" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C597" } ] } ] }, { "uniprot_ac": "Q5F335", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5F335", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F335" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5F335", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F335" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5F335", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F335" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5F335", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F335" } ] } ] }, { "uniprot_ac": "Q5F4B1", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "Q5F4B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F4B1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5F4B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F4B1" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "Q5F4B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5F4B1" } ] } ] }, { "uniprot_ac": "Q5ZKG5", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "Q5ZKG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZKG5" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5ZKG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZKG5" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "Q5ZKG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZKG5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5ZKG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5ZKG5" } ] } ] }, { "uniprot_ac": "Q6YI48", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6YI48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6YI48" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6YI48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6YI48" } ] } ] }, { "uniprot_ac": "Q7T2L9", "gene_name": "MKP3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q7T2L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7T2L9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q7T2L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7T2L9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q7T2L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7T2L9" } ] }, { 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