{ "uniprot_canonical_ac": "A0A193KX02-1", "uniprot_ac": "A0A193KX02", "uniprot_id": "TOMT_DANRE", "mass": { "chemical_mass": 29608.0, "monoisotopic_mass": 29608.0 }, "refseq": { "ac": "NP_001411114", "name": "transmembrane O-methyltransferase homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411114" }, "gene_names": [ { "name": "tomt", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02", "id": "A0A193KX02" }, { "name": "mercury; mrc", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411114", "id": "NP_001411114" }, { "name": "mercury", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02", "id": "A0A193KX02" }, { "name": "mrc", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02", "id": "A0A193KX02" }, { "name": "tomt", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411114", "id": "NP_001411114" } ], "protein_names": [ { "name": "Transmembrane O-methyltransferase homolog", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02/entry#names_and_taxonomy", "id": "A0A193KX02" }, { "name": "2.1.1.6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02/entry#names_and_taxonomy", "id": "A0A193KX02" }, { "name": "Protein mercury", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02/entry#names_and_taxonomy", "id": "A0A193KX02" }, { "name": "protein mercury", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411114", "id": "NP_001411114" }, { "name": "transmembrane O-methyltransferase homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411114", "id": "NP_001411114" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: KX066099.1, SRR32588722.2643588.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476740 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On Sep 8, 2023 this sequence version replaced XP_021322195.1.", "evidence": [ { "database": "RefSeq", "id": "NP_001411114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411114" } ] }, { "annotation": "Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function. Component of the hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (PubMed:28534737).", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02#function" }, { "database": "PubMed", "id": "28534737", "url": "https://glygen.org/publication/PubMed/28534737" }, { "database": "UniProtKB", "id": "P21964", "url": "https://www.uniprot.org/uniprotkb/P21964#function" } ] }, { "annotation": "The authors found that Tmc1/2 proteins are specifically excluded from the hair bundle in tomt mutants, whereas other mechanotransduction complex proteins can still localize to the bundle. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001411114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411114" }, { "database": "PubMed", "id": "28534737", "url": "https://glygen.org/publication/PubMed/28534737" } ] } ], "disease": [ { "disease_id": "DOID:0110515", "recommended_name": { "id": "DOID:0110515", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110515", "name": "autosomal recessive nonsyndromic deafness 63", "description": "An autosomal recessive nonsyndromic deafness that is characterized by prelingual onset with severe to profound, stable hearing loss and has_material_basis_in mutation in the LRTOMT gene on chromosome 11q13." }, "synonyms": [ { "id": "DOID:0110515", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110515", "name": "DFNB63", "description": "" }, { "id": "DOID:0110515", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110515", "name": "autosomal recessive deafness 63", "description": "" }, { "id": "MONDO:0012670", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012670", "name": "autosomal recessive nonsyndromic hearing loss 63", "description": "Any autosomal recessive nonsyndromic deafness in which the cause of the disease is a mutation in the LRTOMT gene." }, { "id": "MONDO:0012670", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012670", "name": "autosomal recessive nonsyndromic hearing loss 63", "description": "" }, { "id": "MONDO:0012670", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012670", "name": "DFNB63", "description": "" }, { "id": "MONDO:0012670", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012670", "name": "LRTOMT autosomal recessive nonsyndromic deafness", "description": "" }, { "id": "MONDO:0012670", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012670", "name": "autosomal recessive deafness 63", "description": "" }, { "id": "MONDO:0012670", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012670", "name": "autosomal recessive nonsyndromic deafness 63", "description": "" }, { "id": "MONDO:0012670", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012670", "name": "autosomal recessive nonsyndromic deafness caused by mutation in LRTOMT", "description": "" }, { "id": "MONDO:0012670", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012670", "name": "autosomal recessive nonsyndromic deafness type 63", "description": "" }, { "id": "MONDO:0012670", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012670", "name": "deafness, autosomal recessive 63", "description": "" }, { "id": "MONDO:0012670", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012670", "name": "deafness, autosomal recessive type 63", "description": "" }, { "id": "MIM:611451", "resource": "MIM", "url": "https://www.omim.org/entry/611451", "name": "Deafness, autosomal recessive, 63", "description": "Deafness, autosomal recessive, 63" } ], "unlinked_id_list": [], "evidence": [ { "id": "0110515", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110515" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "tomt", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-160629-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-160629-1", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "A0A193KX02", "url": "https://alphafold.ebi.ac.uk/entry/A0A193KX02", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSDARG00000115463", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000115463", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "110437932", "url": "https://www.ncbi.nlm.nih.gov/gene/110437932", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002935", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002935", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:110437932", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:110437932", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KWRVHRT", "url": "https://omabrowser.org/oma/group/KWRVHRT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A193KX02", "url": "https://www.orthodb.org/?gene=A0A193KX02", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43836", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43836", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43836:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43836:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01596", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01596", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A193KX02", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:PR_A0A193KX02", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DRE-379397", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-379397", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001411114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411114", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17877", "url": "https://www.rhea-db.org/rhea/17877", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A193KX02-1", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AB13ABH8", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AB13ABH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AB32T7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AB32T7Z5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AB32T7Z5-1", "url": "https://www.uniprot.org/uniprotkb/A0AB32T7Z5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-160629-1", "url": "https://zfin.org/ZDB-GENE-160629-1", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MVSPAIALAFLPLLLTLIIRYRYYFVLLYRAVLTRWVRDCLSGISREERAFQYILTHATPGDSQSILDTFDTWCSKVEFISNIGPKKGKILDRLLQENCPITVLELGTHCGYSTVRMARSLPIGARIYSVEMDQRNAQVAEKIIRLAGFDDDMVELIQRPSDEVIPRLREDLGVERLDLVLMDHWKRCYLPDLHLLEDSGLIGQGSIILADNVIFPGAPNFLRYARRCGLYEVRVHRATLEYMRGIPDGMAELTYIGIK", "length": 259, "header": "sp|A0A193KX02-1|TOMT_DANRE Isoform 1 of Transmembrane O-methyltransferase homolog OS=Danio rerio OX=7955 GN=tomt PE=2 SV=1 CANONICAL=A0A193KX02-1" }, "isoforms": [ { "isoform_ac": "A0A193KX02-1", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02/entry#A0A193KX02-1", "sequence": { "sequence": "MVSPAIALAFLPLLLTLIIRYRYYFVLLYRAVLTRWVRDCLSGISREERAFQYILTHATPGDSQSILDTFDTWCSKVEFISNIGPKKGKILDRLLQENCPITVLELGTHCGYSTVRMARSLPIGARIYSVEMDQRNAQVAEKIIRLAGFDDDMVELIQRPSDEVIPRLREDLGVERLDLVLMDHWKRCYLPDLHLLEDSGLIGQGSIILADNVIFPGAPNFLRYARRCGLYEVRVHRATLEYMRGIPDGMAELTYIGIK", "length": 259, "header": "sp|A0A193KX02-1|TOMT_DANRE Isoform 1 of Transmembrane O-methyltransferase homolog OS=Danio rerio OX=7955 GN=tomt PE=2 SV=1 CANONICAL=A0A193KX02-1" }, "locus": {} }, { "isoform_ac": "A0AB13ABH8-1", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02/entry#A0AB13ABH8-1", "sequence": { "sequence": "MVSPAIALAFLPLLLTLIIRYRYYFVLLYRAVLTRWVRDCLSGISREERAFQYILTHATPGDSQSILDTFDTWCSKVEFISNIGPKKGKILDRLLQENCPITVLELGTHCGYSTVRMARSLPIGARIYSVEMDQRNAQVAEKIIRLAGFDDDMVELIQRPSDEVIPRLREDLGVERLDLVLMDHWKRCYLPDLHLLEDSGLIGQGSIILADNVIFPGAPNFLRYARRCGLYEVRVHRATLEYMRGIPDGMAELTYIGIK", "length": 259, "header": "tr|A0AB13ABH8-1|TOMT_DANRE Computationally mapped isoform of Transmembrane O-methyltransferase homolog OS=Danio rerio OX=7955 GN=tomt PE=2 SV=1 CANONICAL=A0A193KX02-1" }, "locus": {} }, { "isoform_ac": "A0AB32T7Z5-1", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02/entry#A0AB32T7Z5-1", "sequence": { "sequence": "MMSCCGHMTLQVKWRLRCSIIIHEEESDWLLEPVSLHTCLSVCFLSSLSSVILRSVLKMVSPAIALAFLPLLLTLIIRYRYYFVLLYRAVLTRWVRDCLSGISREERAFQYILTHATPGDSQSILDTFDTWCSKVEFISNIGPKKGKILDRLLQENCPITVLELGTHCGYSTVRMARSLPIGARIYSVEMDQRNAQVAEKIIRLAGFDDDMVELIQRPSDEVIPRLREDLGVERLDLVLMDHWKRCYLPDLHLLEDSGLIGQGSIILADNVIFPGAPNFLRYARRCGLYEVRVHRATLEYMRGIPDGMAELTYIGIK", "length": 317, "header": "tr|A0AB32T7Z5-1|TOMT_DANRE Computationally mapped isoform of Transmembrane O-methyltransferase homolog OS=Danio rerio OX=7955 GN=tomt PE=2 SV=1 CANONICAL=A0A193KX02-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Defective calmodulin-dependent rapid apical endocytosis in zebrafish sensory hair cell mutants.", "journal": "J. Neurobiol.", "date": "1999", "authors": "Seiler C, Nicolson T", "evidence": [ { "database": "UniProtKB", "id": "A0AB13ABH8", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABH8" } ], "reference": [ { "type": "PubMed", "id": "10526320", "url": "https://glygen.org/publication/PubMed/10526320" } ] }, { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0AB32T7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AB32T7Z5" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).", "journal": "eLife", "date": "2017", "authors": "Erickson T, Morgan CP, Olt J, Hardy K, Busch-Nentwich E, Maeda R, Clemens R, Krey JF, Nechiporuk A, Barr-Gillespie PG, Marcotti W, Nicolson T", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" }, { "database": "RefSeq", "id": "NP_001411114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411114" } ], "reference": [ { "type": "PubMed", "id": "28534737", "url": "https://glygen.org/publication/PubMed/28534737" } ] }, { "title": "Retrograde Mitochondrial Transport Is Essential for Organelle Distribution and Health in Zebrafish Neurons.", "journal": "J. Neurosci.", "date": "2021", "authors": "Mandal Amrita, Wong Hiu-Tung C, Pinter Katherine, Mosqueda Natalie, Beirl Alisha, Lomash Richa Madan, Won Sehoon, Kindt Katie S, Drerup Catherine M", "evidence": [ { "database": "UniProtKB", "id": "A0AB13ABH8", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABH8" } ], "reference": [ { "type": "PubMed", "id": "33376159", "url": "https://glygen.org/publication/PubMed/33376159" } ] }, { "title": "Alone in a crowd: effect of a nonfunctional lateral line on expression of the social hormone parathyroid hormone 2.", "journal": "Biol. Open", "date": "2022", "authors": "Venuto Alexandra, Smith Cameron P, Cameron-Pack Marybelle, Erickson Timothy", "evidence": [ { "database": "UniProtKB", "id": "A0AB13ABH8", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABH8" } ], "reference": [ { "type": "PubMed", "id": "36161311", "url": "https://glygen.org/publication/PubMed/36161311" } ] }, { "title": "Genetic analysis of vertebrate sensory hair cell mechanosensation: the zebrafish circler mutants.", "journal": "Neuron", "date": "1998", "authors": "Nicolson T, R\u00fcsch A, Friedrich R W, Granato M, Ruppersberg J P, N\u00fcsslein-Volhard C", "evidence": [ { "database": "UniProtKB", "id": "A0AB13ABH8", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABH8" } ], "reference": [ { "type": "PubMed", "id": "9491988", "url": "https://glygen.org/publication/PubMed/9491988" } ] } ], "pathway": [ { "id": "dre:110437932", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:110437932", "resource": "KEGG Pathway" }, { "id": "R-DRE-379397", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-379397", "resource": "Reactome", "description": "Enzymatic degradation of dopamine by COMT" } ], "orthologs": [ { "uniprot_canonical_ac": "A1Y9I9-1", "protein_name": "Transmembrane O-methyltransferase homolog", "gene_name": "Tomt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSPAIALAFLPLVVTLLVRYRHHFRLLVRTVLLRGFRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSCCEYLSHMGPVKGQILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGSRLLTVERDSRTAAVAEKVIRLAGFDEQMVELIAGSSEEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPHGATVLADHVLFPGAPRFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYTGPG", "length": 258 }, "evidence": [ { "id": "MGI:3769724", "url": "https://alliancegenome.org/gene/MGI:3769724#orthology", "database": "AGR" }, { "id": "RGD:1561509", "url": "https://alliancegenome.org/gene/RGD:1561509#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-160629-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-160629-1#orthology", "database": "AGR" }, { "id": "A0A193KX02", "url": "https://omabrowser.org/oma/group/A0A193KX02/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B6CZ62-1", "protein_name": "Transmembrane O-methyltransferase homolog", "gene_name": "Tomt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSPAIALAFLPLVVTLLVRYRHHFRLLVRTVLLRSFRDCLSGLRIEERAFSYVITHALPGDPGHILTTLDHWSSCCEYLSHMGPIKGQILMRLVEEKAPACVLELGTHCGYSTLLIARALPPGSRLLTVERDSRTAAVAEKVIRLAGFDEQMVELIAGSSEEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPHGATVLADHVLFPGAPRFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYTGPG", "length": 258 }, "evidence": [ { "id": "MGI:3769724", "url": "https://alliancegenome.org/gene/MGI:3769724#orthology", "database": "AGR" }, { "id": "RGD:1561509", "url": "https://alliancegenome.org/gene/RGD:1561509#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-160629-1", "url": 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"GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "O-methyltransferase activity", "id": "GO:0008171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008171", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" }, { "name": "catechol O-methyltransferase activity", "id": "GO:0016206", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016206", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "auditory behavior", "id": "GO:0031223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031223", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" }, { "name": "developmental process", "id": "GO:0032502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032502", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" }, { "name": "dopamine metabolic process", "id": "GO:0042417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042417", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" }, { "name": "detection of mechanical stimulus involved in sensory perception", "id": "GO:0050974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050974", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" }, { "name": "inner ear receptor cell stereocilium organization", "id": "GO:0060122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060122", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" }, { "name": "hair cell differentiation", "id": "GO:0035315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035315", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" }, { "name": "catecholamine catabolic process", "id": "GO:0042424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042424", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" }, { "name": "neuromast development", "id": "GO:0048884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048884", "evidence": [ { "database": "UniProtKB", "id": "A0A193KX02", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17877", "name": "", "equation": "a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F4ZGF2-1", "A4IG53-1", "A0A193KX02-1" ], "evidence": [ { "id": "17877", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17877" } ] }, { "id": "R-DRE-8955010", "name": "LRTOMT transfers Met to DA, forming 3MT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A193KX02-1" ], "evidence": [ { "id": "R-DRE-8955010", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-8955010" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A193KX02", "gene_name": "tomt", "activity": [ { "ec_number": "2.1.1.6", "activity": "a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0A193KX02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ] }, { "ec_number": "2.1.1.6", "activity": "", "evidence": [ { "id": "A0A193KX02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A193KX02" } ] } ] }, { "uniprot_ac": "A4IG53", "gene_name": "comtb", "activity": [ { "ec_number": "2.1.1.6", "activity": "a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A4IG53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IG53" } ] }, { "ec_number": "2.1.1.6", "activity": "", "evidence": [ { "id": "A4IG53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IG53" } ] } ] }, { "uniprot_ac": "F4ZGF2", "gene_name": "comta", "activity": [ { "ec_number": "2.1.1.6", "activity": "a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "F4ZGF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F4ZGF2" } ] }, { "ec_number": "2.1.1.6", "activity": "", "evidence": [ { "id": "F4ZGF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F4ZGF2" } ] } ] } ], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.6", "ec_name": "a catechol + S-adenosyl-L-methionine = a guaiacol + 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