{ "uniprot_canonical_ac": "A0A0R4IXF6-1", "uniprot_ac": "A0A0R4IXF6", "uniprot_id": "KAT2A_DANRE", "mass": { "chemical_mass": 90624.0, "monoisotopic_mass": 90624.0 }, "refseq": { "ac": "NP_001410703", "name": "histone acetyltransferase KAT2A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410703" }, "gene_names": [ { "name": "kat2a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6", "id": "A0A0R4IXF6" }, { "name": "gb:dq017634; gcn5; im:7156024", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410703", "id": "NP_001410703" }, { "name": "gb:dq017634", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6", "id": "A0A0R4IXF6" }, { "name": "im:7156024", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6", "id": "A0A0R4IXF6" }, { "name": "kat2a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410703", "id": "NP_001410703" } ], "protein_names": [ { "name": "Histone acetyltransferase KAT2A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6/entry#names_and_taxonomy", "id": "A0A0R4IXF6" }, { "name": "2.3.1.-", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6/entry#names_and_taxonomy", "id": "A0A0R4IXF6" }, { "name": "2.3.1.48", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6/entry#names_and_taxonomy", "id": "A0A0R4IXF6" }, { "name": "Histone glutaryltransferase KAT2A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6/entry#names_and_taxonomy", "id": "A0A0R4IXF6" }, { "name": "Histone succinyltransferase KAT2A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6/entry#names_and_taxonomy", "id": "A0A0R4IXF6" }, { "name": "Lysine acetyltransferase 2A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6/entry#names_and_taxonomy", "id": "A0A0R4IXF6" }, { "name": "PCAF; lysine acetyltransferase 2A; histone succinyltransferase KAT2A; histone glutaryltransferase KAT2A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410703", "id": "NP_001410703" }, { "name": "histone acetyltransferase KAT2A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410703", "id": "NP_001410703" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.3267607.1, SRR32588721.89666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Aug 14, 2023 this sequence version replaced XP_009297593.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.", "evidence": [ { "database": "RefSeq", "id": "NP_001410703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410703" } ] }, { "annotation": "Inhibition of mitochondrial fatty acid beta-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish.", "evidence": [ { "database": "RefSeq", "id": "NP_001410703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410703" }, { "database": "PubMed", "id": "37660921", "url": "https://glygen.org/publication/PubMed/37660921" } ] }, { "annotation": "Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferasesucc, succinyltransferase or malonyltransferase, depending on the context (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (By similarity). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (By similarity). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (By similarity). Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) (By similarity). Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Also acetylates non-histone proteins, such as tbx5 (PubMed:29174768). Involved in heart and limb development by mediating acetylation of tbx5 (PubMed:29174768). Together with kat2b, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (PubMed:30424580). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6#function" }, { "database": "PubMed", "id": "30424580", "url": "https://glygen.org/publication/PubMed/30424580" }, { "database": "PubMed", "id": "29174768", "url": "https://glygen.org/publication/PubMed/29174768" }, { "database": "UniProtKB", "id": "Q92830", "url": "https://www.uniprot.org/uniprotkb/Q92830#function" } ] }, { "annotation": "These studies highlight the importance of KAT2A and KAT2B modulation of TBX5 and their impact on heart and limb development.", "evidence": [ { "database": "RefSeq", "id": "NP_001410703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410703" }, { "database": "PubMed", "id": "29174768", "url": "https://glygen.org/publication/PubMed/29174768" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "kat2a", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6", "locus": {} } ], "crossref": [ { "id": "A0A0R4IXF6", "url": "https://alphafold.ebi.ac.uk/entry/A0A0R4IXF6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSDARG00000104734", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000104734", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04301", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04301", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05509", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05509", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "555517", "url": "https://www.ncbi.nlm.nih.gov/gene/555517", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016376", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016376", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:555517", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:555517", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0R4IXF6", "url": "https://www.orthodb.org/?gene=A0A0R4IXF6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45750", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45750", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45750:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45750:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00439", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00439", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00583", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00583", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF06466", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06466", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A0R4IXF6", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:PR_A0A0R4IXF6", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DRE-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-5689880", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001410703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410703", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16261", "url": "https://www.rhea-db.org/rhea/16261", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "18009", "url": "https://www.rhea-db.org/rhea/18009", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "21992", "url": "https://www.rhea-db.org/rhea/21992", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45948", "url": "https://www.rhea-db.org/rhea/45948", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IXF6-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AB13ABI6", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AB13ABI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABI6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADPAAQSSAQPRLQQAQSSGPTGSNSNPGAGSSDPARPGLSQQQWSSQKKAQVRSFPRAKKLEKLGVFSSCKANDACKCNGWKNPNPPTAARMELQQQAASLTETCRSCGHSLAEHVSHLENVSEEEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMGKPVVEGSLGSPPFEKPNIEQGVLNFVQYKFSHLAPKERQTMYELSKMFLLCLNYWKLETPSQFRQRAQKEDAAAYKVDYTRWLCYCHVPQSNDSLPRYETCQVFGRSLLKSIFTVTRRQLLEKFRVEKDKLPPEKRTLILTHFPKFLSMLEEEIYGENSPIWEADFTMPASEGTQLGHQTVLSPVSISGSPHSKGSSASALGVTGLDVASSEPTIGEKRKLPEALTLEDAKRIRVMGDIPMELVNEVMKTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLSQKSNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHGILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKRQKEIIKKLIERKQNQIRKVYPGLTCFKEGVRQIPVESIPGIRETGWKPSAKEKSKELKDPDLLYNMLKNLLAQIKTHPDAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLKNRYYVTKKLFIADLQRVITNCREYNPPDSEYCKSANTLEKFFYFKLKEAGLIDK", "length": 795, "header": "sp|A0A0R4IXF6-1|KAT2A_DANRE Isoform 1 of Histone acetyltransferase KAT2A OS=Danio rerio OX=7955 GN=kat2a PE=2 SV=1 CANONICAL=A0A0R4IXF6-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IXF6-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6/entry#A0A0R4IXF6-1", "sequence": { "sequence": "MADPAAQSSAQPRLQQAQSSGPTGSNSNPGAGSSDPARPGLSQQQWSSQKKAQVRSFPRAKKLEKLGVFSSCKANDACKCNGWKNPNPPTAARMELQQQAASLTETCRSCGHSLAEHVSHLENVSEEEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMGKPVVEGSLGSPPFEKPNIEQGVLNFVQYKFSHLAPKERQTMYELSKMFLLCLNYWKLETPSQFRQRAQKEDAAAYKVDYTRWLCYCHVPQSNDSLPRYETCQVFGRSLLKSIFTVTRRQLLEKFRVEKDKLPPEKRTLILTHFPKFLSMLEEEIYGENSPIWEADFTMPASEGTQLGHQTVLSPVSISGSPHSKGSSASALGVTGLDVASSEPTIGEKRKLPEALTLEDAKRIRVMGDIPMELVNEVMKTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLSQKSNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHGILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKRQKEIIKKLIERKQNQIRKVYPGLTCFKEGVRQIPVESIPGIRETGWKPSAKEKSKELKDPDLLYNMLKNLLAQIKTHPDAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLKNRYYVTKKLFIADLQRVITNCREYNPPDSEYCKSANTLEKFFYFKLKEAGLIDK", "length": 795, "header": "sp|A0A0R4IXF6-1|KAT2A_DANRE Isoform 1 of Histone acetyltransferase KAT2A OS=Danio rerio OX=7955 GN=kat2a PE=2 SV=1 CANONICAL=A0A0R4IXF6-1" }, "locus": {} }, { "isoform_ac": "A0AB13ABI6-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6/entry#A0AB13ABI6-1", "sequence": { "sequence": "MADPAAQSSAQPRLQQAQSSGPTGSNSNPGAGSSDPARPGLSQQQWSSQKKAQVRSFPRAKKLEKLGVFSSCKANDACKCNGWKNPNPPTAARMELQQQAASLTETCRSCGHSLAEHVSHLENVSEEEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMGKPVVEGSLGSPPFEKPNIEQGVLNFVQYKFSHLAPKERQTMYELSKMFLLCLNYWKLETPSQFRQRAQKEDAAAYKVDYTRWLCYCHVPQSNDSLPRYETCQVFGRSLLKSIFTVTRRQLLEKFRVEKDKLPPEKRTLILTHFPKFLSMLEEEIYGENSPIWEADFTMPASEGTQLGHQTVLSPVSISGSPHSKGSSASALGVTGLDVASSEPTIGEKRKLPEALTLEDAKRIRVMGDIPMELVNEVMKTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLSQKSNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHGILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKRQKEIIKKLIERKQNQIRKVYPGLTCFKEGVRQIPVESIPGIRETGWKPSAKEKSKELKDPDLLYNMLKNLLAQIKTHPDAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLKNRYYVTKKLFIADLQRVITNCREYNPPDSEYCKSANTLEKFFYFKLKEAGLIDK", "length": 795, "header": "tr|A0AB13ABI6-1|KAT2A_DANRE Computationally mapped isoform of Histone acetyltransferase KAT2A OS=Danio rerio OX=7955 GN=kat2a PE=2 SV=1 CANONICAL=A0A0R4IXF6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 23, "start_aa": "Thr", "end_pos": 23, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr23", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "00000000000000001000.00000000001000.0.xxxxx" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression.", "journal": "PLoS Genet.", "date": "2007", "authors": "Bertrand St\u00e9phanie, Thisse Bernard, Tavares Raquel, Sachs Laurent, Chaumot Arnaud, Bardet Pierre-Luc, Escriv\u00e0 H\u00e9ctor, Duffraisse Maryline, Marchand Oriane, Safi Rachid, Thisse Christine, Laudet Vincent", "evidence": [ { "database": "UniProtKB", "id": "A0AB13ABI6", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABI6" } ], "reference": [ { "type": "PubMed", "id": "17997606", "url": "https://glygen.org/publication/PubMed/17997606" } ] }, { "title": "Evolution of JAK-STAT pathway components: mechanisms and role in immune system development.", "journal": "PLoS ONE", "date": "2012", "authors": "Liongue Clifford, O'Sullivan Lynda A, Trengove Monique C, Ward Alister C", "evidence": [ { "database": "UniProtKB", "id": "A0AB13ABI6", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABI6" } ], "reference": [ { "type": "PubMed", "id": "22412924", "url": "https://glygen.org/publication/PubMed/22412924" } ] }, { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0AB13ABI6", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABI6" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "A network of epigenetic regulators guides developmental haematopoiesis in vivo.", "journal": "Nat. Cell Biol.", "date": "2013", "authors": "Huang Hsuan-Ting, Kathrein Katie L, Barton Abby, Gitlin Zachary, Huang Yue-Hua, Ward Thomas P, Hofmann Oliver, Dibiase Anthony, Song Anhua, Tyekucheva Svitlana, Hide Winston, Zhou Yi, Zon Leonard I", "evidence": [ { "database": "UniProtKB", "id": "A0AB13ABI6", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABI6" } ], "reference": [ { "type": "PubMed", "id": "24240475", "url": "https://glygen.org/publication/PubMed/24240475" } ] }, { "title": "Transcriptional and histological alterations in gonad of adult zebrafish after exposure to the synthetic progestin norgestrel.", "journal": "Environ. Toxicol. Chem.", "date": "2017", "authors": "Shi Wen-Jun, Zhao Jian-Liang, Jiang Yu-Xia, Huang Guo-Yong, Liu You-Sheng, Zhang Jin-Na, Ying Guang-Guo", "evidence": [ { "database": "UniProtKB", "id": "A0AB13ABI6", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABI6" } ], "reference": [ { "type": "PubMed", "id": "28631837", "url": "https://glygen.org/publication/PubMed/28631837" } ] }, { "title": "Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.", "journal": "Journal of molecular and cellular cardiology", "date": "2018", "authors": "Ghosh TK, Aparicio-Sanchez JJ, Buxton S, Ketley A, Mohamed T, Rutland CS, Loughna S, Brook JD", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" }, { "database": "RefSeq", "id": "NP_001410703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410703" } ], "reference": [ { "type": "PubMed", "id": "29174768", "url": "https://glygen.org/publication/PubMed/29174768" } ] }, { "title": "Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice.", "journal": "Journal of developmental biology", "date": "2018-11-12", "authors": "Sen Rwik, Pezoa Sofia A, Carpio Shull Lomeli, Hernandez-Lagunas Laura, Niswander Lee A, Artinger Kristin Bruk", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "reference": [ { "type": "PubMed", "id": "30424580", "url": "https://glygen.org/publication/PubMed/30424580" } ] }, { "title": "Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (HDAC) and lysine acetyltransferase (KAT) genes.", "journal": "Gene", "date": "2019", "authors": "Fellous Alexandre, Earley Ryan L, Silvestre Frederic", "evidence": [ { "database": "UniProtKB", "id": "A0AB13ABI6", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABI6" } ], "reference": [ { "type": "PubMed", "id": "30615915", "url": "https://glygen.org/publication/PubMed/30615915" } ] }, { "title": "Medroxyprogesterone acetate affects eye growth and the transcription of associated genes in zebrafish.", "journal": "Ecotoxicol. Environ. Saf.", "date": "2020", "authors": "Shi Wen-Jun, Huang Guo-Yong, Jiang Yu-Xia, Ma Dong-Dong, Chen Hong-Xing, Huang Ming-Zhi, Hou Ling-Ping, Xie Lingtian, Ying Guang-Guo", "evidence": [ { "database": "UniProtKB", "id": "A0AB13ABI6", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABI6" } ], "reference": [ { "type": "PubMed", "id": "32114246", "url": "https://glygen.org/publication/PubMed/32114246" } ] }, { "title": "Building the vertebrate codex using the gene breaking protein trap library.", "journal": "Elife", "date": "2020", "authors": "Ichino Noriko, Serres MaKayla R, Urban Rhianna M, Urban Mark D, Treichel Anthony J, Schaefbauer Kyle J, Tallant Lauren E, Varshney Gaurav K, Skuster Kimberly J, McNulty Melissa S, Daby Camden L, Wang Ying, Liao Hsin-Kai, El-Rass Suzan, Ding Yonghe, Liu Weibin, Anderson Jennifer L, Wishman Mark D, Sabharwal Ankit, Schimmenti Lisa A, Sivasubbu Sridhar, Balciunas Darius, Hammerschmidt Matthias, Farber Steven Arthur, Wen Xiao-Yan, Xu Xiaolei, McGrail Maura, Essner Jeffrey J, Burgess Shawn M, Clark Karl J, Ekker Stephen C", "evidence": [ { "database": "UniProtKB", "id": "A0AB13ABI6", "url": "https://www.uniprot.org/uniprotkb/A0AB13ABI6" } ], "reference": [ { "type": "PubMed", "id": "32779569", "url": "https://glygen.org/publication/PubMed/32779569" } ] }, { "title": "Inhibition of mitochondrial fatty acid \u03b2-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish.", "journal": "The Journal of biological chemistry", "date": "2023-10", "authors": "Zhou Wen-Hao, Luo Yuan, Li Rui-Xin, Degrace Pascal, Jourdan Tony, Qiao Fang, Chen Li-Qiao, Zhang Mei-Ling, Du Zhen-Yu", "evidence": [ { "database": "RefSeq", "id": "NP_001410703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410703" } ], "reference": [ { "type": "PubMed", "id": "37660921", "url": "https://glygen.org/publication/PubMed/37660921" } ] } ], "pathway": [ { "id": "dre:555517", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:555517", "resource": "KEGG Pathway" }, { "id": "R-DRE-5689880", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "histone acetyltransferase complex", "id": "GO:0000123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000123", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "ATAC complex", "id": "GO:0140672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140672", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 17, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "regulation of bone development", "id": "GO:1903010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903010", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "regulation of synaptic plasticity", "id": "GO:0048167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048167", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "positive regulation of cytokine production", "id": "GO:0001819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001819", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "limb development", "id": "GO:0060173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060173", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "bone morphogenesis", "id": "GO:0060349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060349", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "long-term memory", "id": "GO:0007616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007616", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "epigenetic regulation of gene expression", "id": "GO:0040029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040029", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "internal peptidyl-lysine acetylation", "id": "GO:0018393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018393", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "regulation of T cell activation", "id": "GO:0050863", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050863", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "regulation of cartilage development", "id": "GO:0061035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061035", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "regulation of regulatory T cell differentiation", "id": "GO:0045589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045589", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "peptidyl-lysine glutarylation", "id": "GO:0106227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106227", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "histone H3K9 acetyltransferase activity", "id": "GO:0043992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043992", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "protein-lysine-acetyltransferase activity", "id": "GO:0061733", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061733", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "histone succinyltransferase activity", "id": "GO:0106078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106078", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "histone acetyltransferase activity", "id": "GO:0004402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004402", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "histone H3 acetyltransferase activity", "id": "GO:0010484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010484", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" }, { "name": "histone glutaryltransferase activity", "id": "GO:0106229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106229", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IXF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16261", "name": "", "equation": "succinyl-CoA + L-lysyl-[protein] = N(6)-succinyl-L-lysyl-[protein] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0R4IXF6-1" ], "evidence": [ { "id": "16261", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16261" } ] }, { "id": "18009", "name": "", "equation": "glutaryl-CoA + L-lysyl-[protein] = N(6)-glutaryl-L-lysyl-[protein] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0R4IXF6-1" ], "evidence": [ { "id": "18009", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18009" } ] }, { "id": "21992", "name": "", "equation": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q1LUC3-1", "Q6DHD0-1", "A0A8M9QDW0-1", "A0A0R4IXF6-1", "F1Q712-1", "A0A8M1PHR3-1" ], "evidence": [ { "id": "21992", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21992" } ] }, { "id": "45948", "name": "", "equation": "L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A3KPA3-1", "A2CG09-1", "Q1LUC3-1", "Q5SPR8-1", "A0A8M3BER5-1", "Q7SX98-1", "Q66HU5-1", "A0A8M9QDK0-1", "A0A0R4IXF6-1", "Q7ZW29-1", "A0A8M1PHR3-1" ], "evidence": [ { "id": "45948", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45948" } ] }, { "id": "R-DRE-5690080", "name": "USP3,SAGA deubiquitinate Histone H2A,H2B", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A6H8I0-1", "A0A0R4IXF6-1" ], "evidence": [ { "id": "R-DRE-5690080", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-5690080" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0R4IXF6", "gene_name": "kat2a", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A0R4IXF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "A0A0R4IXF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A0R4IXF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IXF6" } ] } ] }, { "uniprot_ac": "A0A8M1PHR3", "gene_name": "kat8", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A8M1PHR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1PHR3" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8M1PHR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1PHR3" } ] } ] }, { "uniprot_ac": "A0A8M3BER5", "gene_name": "kat6b", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A8M3BER5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3BER5" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8M3BER5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3BER5" } ] } ] }, { "uniprot_ac": "A0A8M9QDK0", "gene_name": "ncoa3", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A8M9QDK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9QDK0" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8M9QDK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9QDK0" } ] } ] }, { "uniprot_ac": "A0A8M9QDW0", "gene_name": "kat5b", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A8M9QDW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9QDW0" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8M9QDW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9QDW0" } ] } ] }, { "uniprot_ac": "A2CG09", "gene_name": 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