{ "uniprot_canonical_ac": "A0A0R4IX64-1", "uniprot_ac": "A0A0R4IX64", "uniprot_id": "A0A0R4IX64_DANRE", "mass": { "chemical_mass": 73492.0, "monoisotopic_mass": 73492.0 }, "refseq": {}, "gene_names": [ { "name": "LOC137487234", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64", "id": "A0A0R4IX64" }, { "name": "lratb.1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64", "id": "A0A0R4IX64" } ], "protein_names": [ { "name": "Si:ch73-132f6.5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64/entry#names_and_taxonomy", "id": "A0A0R4IX64" }, { "name": "Uncharacterized protein lratb.1 isoform X1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64/entry#names_and_taxonomy", "id": "A0A0R4IX64" } ], "function": [], "disease": [ { "disease_id": "DOID:0110188", "recommended_name": { "id": "DOID:0110188", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110188", "name": "Leber congenital amaurosis 14", "description": "A Leber congenital amaurosis that has_material_basis_in mutation in the LRAT gene on chromosome 4q31." }, "synonyms": [ { "id": "DOID:0110188", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110188", "name": "LCA14", "description": "" }, { "id": "MONDO:0013231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013231", "name": "Leber congenital amaurosis 14", "description": "Any Leber congenital amaurosis in which the cause of the disease is a mutation in the LRAT gene." }, { "id": "MONDO:0013231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013231", "name": "LCA14", "description": "" }, { "id": "MONDO:0013231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013231", "name": "LRAT Leber congenital amaurosis", "description": "" }, { "id": "MONDO:0013231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013231", "name": "Leber congenital amaurosis 14", "description": "" }, { "id": "MONDO:0013231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013231", "name": "Leber congenital amaurosis caused by mutation in LRAT", "description": "" }, { "id": "MONDO:0013231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013231", "name": "Leber congenital amaurosis type 14", "description": "" }, { "id": "MONDO:0013231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013231", "name": "retinal dystrophy, early-onset severe", "description": "" }, { "id": "MONDO:0013231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013231", "name": "retinal dystrophy, early-onset Severe, LRAT-related", "description": "" }, { "id": "MONDO:0013231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013231", "name": "retinitis pigmentosa, juvenile", "description": "" }, { "id": "MONDO:0013231", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013231", "name": "retinitis pigmentosa, juvenile, LRAT-related", "description": "" }, { "id": "MIM:613341", "resource": "MIM", "url": "https://www.omim.org/entry/613341", "name": "Leber congenital amaurosis 14", "description": "Leber congenital amaurosis 14" } ], "unlinked_id_list": [], "evidence": [ { "id": "0110188", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110188" } ] }, { "disease_id": "DOID:10584", "recommended_name": { "id": "DOID:10584", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10584", "name": "retinitis pigmentosa", "description": "A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss." }, "synonyms": [ { "id": "DOID:10584", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10584", "name": "pericentral pigmentary retinopathy", "description": "" }, { "id": "MONDO:0019200", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019200", "name": "retinitis pigmentosa", "description": "Retinitis pigmentosa (RP) is an inherited retinal dystrophy leading to progressive loss of the photoreceptors and retinal pigment epithelium and resulting in blindness usually after several decades." }, { "id": "MONDO:0019200", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019200", "name": "retinitis pigmentosa", "description": "" }, { "id": "MONDO:0019200", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019200", "name": "pericentral pigmentary retinopathy", "description": "" }, { "id": "MONDO:0019200", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019200", "name": "Rod-cone dystrophy", "description": "" }, { "id": "MIM:268000", "resource": "MIM", "url": "https://www.omim.org/entry/268000", "name": "Retinitis pigmentosa", "description": "Retinitis pigmentosa" } ], "unlinked_id_list": [], "evidence": [ { "id": "10584", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10584" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IX64", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "lratb.1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-060810-31", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060810-31", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000096594", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000096594", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSDARG00000104660", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000104660", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "137487234", "url": "https://www.ncbi.nlm.nih.gov/gene/137487234", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "553501", "url": "https://www.ncbi.nlm.nih.gov/gene/553501", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042288", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042288", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056362", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056362", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:137487234", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:137487234", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "dre:553501", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:553501", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YEHIGFP", "url": "https://omabrowser.org/oma/group/YEHIGFP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IX64", "url": "https://www.orthodb.org/?gene=A0A0R4IX64", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A2R8PZT4", "url": "https://www.orthodb.org/?gene=A0A2R8PZT4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46678", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46678", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46678:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46678:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47708", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47708", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47708:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47708:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04970", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04970", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07287", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07287", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF23544", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23544", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_009304590", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009304590", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4IX64", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IX64-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8PZT4", "url": "https://www.uniprot.org/uniprotkb/A0A2R8PZT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8PZT4-1", "url": "https://www.uniprot.org/uniprotkb/A0A2R8PZT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M9Q803", "url": "https://www.uniprot.org/uniprotkb/A0A8M9Q803", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M9Q803-1", "url": "https://www.uniprot.org/uniprotkb/A0A8M9Q803-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-030131-9581", "url": "https://zfin.org/ZDB-GENE-030131-9581", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] }, { "id": "ZDB-GENE-060810-31", "url": "https://zfin.org/ZDB-GENE-060810-31", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MANLTRVSGSLHRLTVKVCSTSPLPFCGYSVLYPHSLSNVKSATVRCFARDSRHRHNIRHYSSSAHKTVRIGCASGFWGDTATSVPQLIYGGKLDFLVFDYLSEITMSLLSAAKAKAPQMGYAPDFVLSLSPFINDISKRGIRVVSNAGGVNPLACGAALQEVIQKAGLDLKVAVVTGDDLMPQKDSLTELRMTDAERKKPLPKTVHSMNVYLGALPIKRCLDLGADIVVTGRCVDSAVVLGPLMHSFAWDGSNHDLLAAGSLAGHLIECGAQATGGIFTDWHTVPDWDNMGFPVVECSADGSFTLCKPPKTGGLVSFGTVAEQLVYEIGDPRHYLLPDVTCDFSNVTITEITDVDGGAVKVGGAKGSPPSGDYKVCATYMDGFRATAVCPVGGPRAVEKARRTAESIIKRTQRIFKQLGLEDYTEVNIQVLGAEDTYGPHAVNTGVREAVVWMAVHHKQKKALEFFSREVAPAGTGMAPGLTAIVGGRPRISPVLKPFFFLYPKSDLEVQIHVNGEHVETHREAVSEPSLGETHNSSLRSEESSLSSTDLPSGPHTFRLEELAYTRSGDKGDSANIGVIARHPQYFPYLKKFITAEVVEQYFQHLIRKDQTGQPSVIRYELPGIHGLNFILLNSLGGGGVASLRSDPQGKAYGQMLLDYKLQGLPDLKSLINQKRVED", "length": 679, "header": "tr|A0A0R4IX64-1|A0A0R4IX64_DANRE Isoform 1 of Si:ch73-132f6.5 OS=Danio rerio OX=7955 GN=lratb.1 PE=1 SV=1 CANONICAL=A0A0R4IX64-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IX64-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64/entry#A0A0R4IX64-1", "sequence": { "sequence": "MANLTRVSGSLHRLTVKVCSTSPLPFCGYSVLYPHSLSNVKSATVRCFARDSRHRHNIRHYSSSAHKTVRIGCASGFWGDTATSVPQLIYGGKLDFLVFDYLSEITMSLLSAAKAKAPQMGYAPDFVLSLSPFINDISKRGIRVVSNAGGVNPLACGAALQEVIQKAGLDLKVAVVTGDDLMPQKDSLTELRMTDAERKKPLPKTVHSMNVYLGALPIKRCLDLGADIVVTGRCVDSAVVLGPLMHSFAWDGSNHDLLAAGSLAGHLIECGAQATGGIFTDWHTVPDWDNMGFPVVECSADGSFTLCKPPKTGGLVSFGTVAEQLVYEIGDPRHYLLPDVTCDFSNVTITEITDVDGGAVKVGGAKGSPPSGDYKVCATYMDGFRATAVCPVGGPRAVEKARRTAESIIKRTQRIFKQLGLEDYTEVNIQVLGAEDTYGPHAVNTGVREAVVWMAVHHKQKKALEFFSREVAPAGTGMAPGLTAIVGGRPRISPVLKPFFFLYPKSDLEVQIHVNGEHVETHREAVSEPSLGETHNSSLRSEESSLSSTDLPSGPHTFRLEELAYTRSGDKGDSANIGVIARHPQYFPYLKKFITAEVVEQYFQHLIRKDQTGQPSVIRYELPGIHGLNFILLNSLGGGGVASLRSDPQGKAYGQMLLDYKLQGLPDLKSLINQKRVED", "length": 679, "header": "tr|A0A0R4IX64-1|A0A0R4IX64_DANRE Isoform 1 of Si:ch73-132f6.5 OS=Danio rerio OX=7955 GN=lratb.1 PE=1 SV=1 CANONICAL=A0A0R4IX64-1" }, "locus": {} }, { "isoform_ac": "A0A2R8PZT4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64/entry#A0A2R8PZT4-1", "sequence": { "sequence": "MLDSLSLLLEKTLLLAHFNFFSTTSSKQERCTKRREESTYFQRGDLLEVPRTLFTHFGIYLGDNKVAHLMPDILPVLTSNKSHLQNVVTNKRLLLGVLYKYASVRVDTVEDFAYGSNILLNTMDTTLRKQPLAAEEVARRAEKLVGHFPYSLMWNNCEHFVTYCRYGTAVSLQTDQFCESLKSIIRDQRSILLTTVIGMLSMFFVGIAPSTALPTFIIPFILWMAG", "length": 226, "header": "tr|A0A2R8PZT4-1|A0A0R4IX64_DANRE Computationally mapped isoform of Si:ch73-132f6.5 OS=Danio rerio OX=7955 GN=lratb.1 PE=1 SV=1 CANONICAL=A0A0R4IX64-1" }, "locus": {} }, { "isoform_ac": "A0A8M9Q803-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64/entry#A0A8M9Q803-1", "sequence": { "sequence": "MANLTRVSGSLHRLTVKVCSTSPLPFCGYSVLYPHSLSNVKSATVRCFARDSRHRHNIRHYSSSAHKTVRIGCASGFWGDTATSVPQLIYGGKLDFLVFDYLSEITMSLLSAAKAKAPQMGYAPDFVLSLSPFINDISKRGIRVVSNAGGVNPLACGAALQEVIQKAGLDLKVAVVTGDDLMPQKDSLTELRMTDAERKKPLPKTVHSMNVYLGALPIKRCLDLGADIVVTGRCVDSAVVLGPLMHSFAWDGSNHDLLAAGSLAGHLIECGAQATGGIFTDWHTVPDWDNMGFPVVECSADGSFTLCKPPKTGGLVSFGTVAEQLVYEIGDPRHYLLPDVTCDFSNVTITEITDVDGGAVKVGGAKGSPPSGDYKVCATYMDGFRATAVCPVGGPRAVEKARRTAESIIKRTQRIFKQLGLEDYTEVNIQVLGAEDTYGPHAVNTGVREAVVWMAVHHKQKKALEFFSREVAPAGTGMAPGLTAIVGGRPRISPVLKPFFFLYPKSDLEVQIHVNGEHVETHREAVSEPSLGETHNSSLRSEESSLSSTDLPSGPHTFRLEELAYTRSGDKGDSANIGVIARHPQYFPYLKKFITAEVVEQYFQHLIRKDQTGQPSVIRFIGGKIYSVTQSCGHGYDLVVLC", "length": 642, "header": "tr|A0A8M9Q803-1|A0A0R4IX64_DANRE Computationally mapped isoform of Si:ch73-132f6.5 OS=Danio rerio OX=7955 GN=lratb.1 PE=1 SV=1 CANONICAL=A0A0R4IX64-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A8M9Q803", "url": "https://www.uniprot.org/uniprotkb/A0A8M9Q803" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] } ], "pathway": [ { "id": "dre:137487234", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:137487234", "resource": "KEGG Pathway" }, { "id": "dre:553501", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:553501", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YS78-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC100857197", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSFAALLRLRRPRLLRPVPRPQRWNRRRGSGCEPPAGAAVRIGCASGFWGDTAAAVPQLLYGGKLDFLVFDYLSEITMSLLTAAKARSPVLGYAPDFISTAMAPYIKDIHRKGIRVISNAGGINPLACAATLQEVAEKADIDLKIAVITGDDLMSEKENLRGAGITDLESGKPFPDSVHSMNVYLGARPISRALDLGADVVITGRCVDSGIVLGALIHSFGWNRDEFDLLAAGSLAGHLIECGAQCTGGIFTDWHVVPDWHNIGFPIVECSSEGDLIISKPPDTGGLISFGTVAEQLVYELGNPQRYLLPDVTCDFSEVSITEIPGFEGGAVKVHGAKGSPPSTFYKVSATYLDGFRATAVCPVGGPKAVQKGKLTAESILKRTRFMFSQLGYEDYSAVNIQVLGSEDTYGPHARRSIDGQGPREAVIWLAVHHKQKEALEIFSKEIAPAGAGMAPGLTGVIGGRPRISPVLKPFFFRYPKSNVQINLFLNGQYVETFEEDLTFTSDEAVSFDPPRINSELKDLPSGHHTYRLEDLAYTRSGDKGNSANIGVIARHPLYYPYLKKTLTAQALENYFEHLLEREKPEEELVSRYELPGIHALNFVLKNSLGGGGIASLRSDPQGKALGQMLLDFQIKNVPDLKSLIE", "length": 646 }, "evidence": [ { "id": "A0A0R4IX64", "url": "https://omabrowser.org/oma/group/A0A0R4IX64/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B3DHX4-1", "protein_name": "Lecithin retinol acyltransferase-like", "gene_name": "lratb.2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFPLQFFSLFYIAVLADFEEKKKRQTLQYDLSKYKRGDLLEVPRTLFTHFGIYLGNNRVAHLIPDILPVWTTDQKAIQKMVTNNRLILGVIAKKASVRVDSVEDFAYGAEILVNHMDKVCSRAAFEGEEVARRAEKLCGSVVYSLLWYNCEHYVMYCRYGTSMSFQTYQFCKAVRKIVCSKMSSLISLLLGLFIMFYLQSVTLFGILPTIIIPFTIWMAS", "length": 220 }, "evidence": [ { "id": "MGI:1891259", "url": "https://alliancegenome.org/gene/MGI:1891259#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1Q7T8-1", "protein_name": "2.3.1.135", "gene_name": "lrata", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLDSLTFLFEKFFLFSNFNLFKSIWQPEKEECAVKCHPALRRGDLLEVQRTLFIHYGIYLGENRVAHLMPDIMPLLTSNKQHIKPVVTNKRLILGCMYRLASIRVDSVEDFAYGAPILTNDMDKKMKCQVLANEEVARRAEKLVGDIPYSLLWNNCEHFVTYCRYGTPVSEQTDKFCNCLKSIIRDQRSVALTIGMGVMYILCFGLAPSTTLPTILIPFILWMAG", "length": 225 }, "evidence": [ { "id": "MGI:1891259", "url": "https://alliancegenome.org/gene/MGI:1891259#orthology", "database": "AGR" }, { "id": "HGNC:6685", "url": "https://alliancegenome.org/gene/HGNC:6685#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O95237-1", "protein_name": "Lecithin retinol acyltransferase", "gene_name": "LRAT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKNPMLEVVSLLLEKLLLISNFTLFSSGAAGEDKGRNSFYETSSFHRGDVLEVPRTHLTHYGIYLGDNRVAHMMPDILLALTDDMGRTQKVVSNKRLILGVIVKVASIRVDTVEDFAYGANILVNHLDESLQKKALLNEEVARRAEKLLGFTPYSLLWNNCEHFVTYCRYGTPISPQSDKFCETVKIIIRDQRSVLASAVLGLASIVCTGLVSYTTLPAIFIPFFLWMAG", "length": 230 }, "evidence": [ { "id": "MGI:1891259", "url": "https://alliancegenome.org/gene/MGI:1891259#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060810-31", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060810-31#orthology", "database": "AGR" }, { "id": "HGNC:6685", "url": "https://alliancegenome.org/gene/HGNC:6685#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54RD7-1", "protein_name": "DUF1446-domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKMKQTTTTTIKMNKDILRIGSGAGYQGDRVPPAVQLVEKGKLDYLVLECLAERTLTDSIRRMKNNGKGYDPRLKEWLTSLLPPAKKRNVTIITNMGAADPKGAGEEAFEIAKSLGLNHIKIVVISENIHNNDNNQNNSNNNNNNNKKYNIKLSSTNGFAVDGGLDSDQHSIEENWEVGCTYLGADAIIDALKLNPDLVIAGRVADPSLFVAPIAFTFGWDLKNDMNLIAQATLAGHLLECACHLTGGYFAHPLGRDMKFEDLLNLSLPFCDIDCNGRIILGKVEGSGGELSERTCKQQLTYEIGNPKEYITPDAIVDFSKVEFIPISENSVIARGAIGTQRPKTLLRLVARNAGFKAWAEVSYGGLGCVERAYWANKLIYHWMESRKKGIMNDVFSYLLGYNSLYFPHGSNFSYPPISIEKLLNNNNSNNDNNNNNNDNNNNNNNSNNNDINIKNFQQFNNQYPPEVRLRLDGLFQNKEDAEALGMELQGLGLCGPAGGGGFAFGIKKDVRLVKQLIPREKINWNTFIFQNNNNNNNNNNNNNNNNNNNLNSINNGYKIINNNNNNDLDIFINEFKTIKNQNIITYSKGFRFNRCNKNNNNNSSNSNNNNNNNSNNNGKVLLYNICHSRSGDKGDTTNVSLIPYDIKDFDRIKKVVTKEWVSKIYGNLLRGEPDISIYSLPGISSLNIVLNNALDGGVCVSRRIDRHGKTLSDLILNQWVDLPKLSNL", "length": 729 }, "evidence": [ { "id": "A0A0R4IX64", "url": "https://omabrowser.org/oma/group/A0A0R4IX64/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9JI60-1", "protein_name": "Lecithin retinol acyltransferase", "gene_name": "Lrat", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKNPMLEAASLLLEKLLLISNFKLFSVSVPGGGTGKNRPYEISSFVRGDVLEVSRTHFIHYGIYLGENRVAHLMPDILLALTNDKERTQKVVSNKRLLLGVICKVASIRVDTVEDFAYGADILVNHLDGTLKKKSLLNEEVARRAEQQLGLTPYSLLWNNCEHFVTYCRYGSRISPQAEKFYDTVKIIIRDQRSSLASAVLGLASIVYTGLASYMTLPAICIPFCLWMMSG", "length": 231 }, "evidence": [ { "id": "MGI:1891259", "url": "https://alliancegenome.org/gene/MGI:1891259#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060810-31", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060810-31#orthology", "database": "AGR" }, { "id": "HGNC:6685", "url": "https://alliancegenome.org/gene/HGNC:6685#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JI61-1", "protein_name": "Lecithin retinol acyltransferase", "gene_name": "Lrat", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKNSMLEAASLLLEKLLLISNFKIFSVCAPGGGTGKKHPYEINSFLRGDVLEVSRTHFTHYGIYLGDNRVAHLMPDILLALTSDKERTQKVVSNKRLLPGVICKVASIRVDTVEDFAYGADILVNHLDETLKKKSLLNEEVARRAEQQLGLTPYSLLWNNCEHFVTYCRYGSPISPQAEKFHETVKILIRDQRSCLASAVLGLVSIIYTGLASYMTLPAVCIPFCLWMMSG", "length": 231 }, "evidence": [ { "id": "MGI:1891259", "url": "https://alliancegenome.org/gene/MGI:1891259#orthology", "database": "AGR" }, { "id": "HGNC:6685", "url": "https://alliancegenome.org/gene/HGNC:6685#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidylcholine-retinol O-acyltransferase activity", "id": "GO:0047173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047173", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IX64", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "rough endoplasmic reticulum", "id": "GO:0005791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005791", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IX64", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IX64", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "retinol metabolic process", "id": "GO:0042572", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042572", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IX64", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64" } ], "pmid": "" }, { "name": "vitamin A metabolic process", "id": "GO:0006776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006776", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IX64", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IX64" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 346, "end_pos": 348, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 536, "end_pos": 538, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 346, "end_pos": 348 }, { "start_pos": 3, "end_pos": 5 }, { "start_pos": 536, "end_pos": 538 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }