{ "uniprot_canonical_ac": "A0A0R4IVV0-1", "uniprot_ac": "A0A0R4IVV0", "uniprot_id": "MTP_DANRE", "mass": { "chemical_mass": 96988.0, "monoisotopic_mass": 96988.0 }, "refseq": { "ac": "NP_998135", "name": "microsomal triglyceride transfer protein large subunit precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998135" }, "gene_names": [ { "name": "mttp", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0", "id": "A0A0R4IVV0" }, { "name": "mtp; stl; wu:fd36b01; zgc:111876; zgc:136353", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998135", "id": "NP_998135" }, { "name": "mtp", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0", "id": "A0A0R4IVV0" }, { "name": "mttp", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998135", "id": "NP_998135" } ], "protein_names": [ { "name": "Microsomal triglyceride transfer protein large subunit", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0/entry#names_and_taxonomy", "id": "A0A0R4IVV0" }, { "name": "microsomal triglyceride transfer protein large subunit precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998135", "id": "NP_998135" }, { "name": "stalactite; microsomal triglyceride transfer protein large subunit", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998135", "id": "NP_998135" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: AJ428850.1, BC135020.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Jun 25, 2025 this sequence version replaced NP_998135.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.", "evidence": [ { "database": "RefSeq", "id": "NP_998135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998135" } ] }, { "annotation": "Analysis of developmental expression and nutritional regulation of zebrafish homolog to mammalian microsomal triglyceride transfer protein large subunit", "evidence": [ { "database": "RefSeq", "id": "NP_998135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998135" }, { "database": "PubMed", "id": "15614773", "url": "https://glygen.org/publication/PubMed/15614773" } ] }, { "annotation": "Catalyzes the transport of triglyceride between phospholipid surfaces (PubMed:17924655). Catalyzes the transport of cholesteryl ester, and phospholipid between phospholipid surfaces (By similarity). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:17924655, PubMed:22581286). Required for yolk lipid utilization and absorption of dietary lipids in larvae (PubMed:17176039).", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0#function" }, { "database": "PubMed", "id": "17176039", "url": "https://glygen.org/publication/PubMed/17176039" }, { "database": "PubMed", "id": "22581286", "url": "https://glygen.org/publication/PubMed/22581286" }, { "database": "UniProtKB", "id": "P55157", "url": "https://www.uniprot.org/uniprotkb/P55157#function" }, { "database": "PubMed", "id": "17924655", "url": "https://glygen.org/publication/PubMed/17924655" } ] }, { "annotation": "In a genetic study of lipid transport and metabolism, larval levels of microsomal triglyceride transfer protein (Mtp), the protein responsible for packaging triacylglycerol and beta-lipoproteins into lipoprotein particles, are unchanged by feeding.", "evidence": [ { "database": "RefSeq", "id": "NP_998135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998135" }, { "database": "PubMed", "id": "17176039", "url": "https://glygen.org/publication/PubMed/17176039" } ] } ], "disease": [ { "disease_id": "DOID:0080208", "recommended_name": { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "metabolic dysfunction-associated steatotic liver disease", "description": "A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and no other discernible cause with normal to no alcohol use. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol." }, "synonyms": [ { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "nonalcoholic fatty liver disease", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "non-alcoholic fatty liver disease", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "NAFLD", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "metabolic dysfunction-associated fatty liver disease", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "metabolic dysfunction-related steatotic liver disease", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "MAFLD", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "MASLD", "description": "" }, { "id": "DOID:0080208", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080208", "name": "metabolic-associated fatty liver disease", "description": "" }, { "id": "MONDO:0013246", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013246", "name": "fatty liver disease, nonalcoholic, susceptibility to, 2", "description": "" }, { "id": "MONDO:0013246", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013246", "name": "NAFLD2", "description": "" }, { "id": "MONDO:0013246", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013246", "name": "fatty liver disease, nonalcoholic, susceptibility to, 2", "description": "" }, { "id": "MONDO:0021105", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021105", "name": "NAFLD1", "description": "" }, { "id": "MONDO:0021105", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021105", "name": "NAFLD1", "description": "" }, { "id": "MONDO:0021105", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021105", "name": "fatty liver disease, nonalcoholic, susceptibility to, 1", "description": "" }, { "id": "MONDO:0021105", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0021105", "name": "liver disease, alcoholic, susceptibility to, 1", "description": "" }, { "id": "MIM:613282", "resource": "MIM", "url": "https://www.omim.org/entry/613282", "name": "Non-alcoholic fatty liver disease 1", "description": "Non-alcoholic fatty liver disease 1" } ], "unlinked_id_list": [], "evidence": [ { "id": "0080208", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080208" } ] }, { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "unlinked_id_list": [ "DOID:11130" ], "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] }, { "disease_id": "DOID:1168", "recommended_name": { "id": "DOID:1168", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1168", "name": "familial hyperlipidemia", "description": "" }, "synonyms": [ { "id": "DOID:1168", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1168", "name": "familial hyperlipoproteinemia", "description": "" }, { "id": "DOID:1168", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1168", "name": "hyperlipemia", "description": "" } ], "unlinked_id_list": [ "DOID:0111417" ], "evidence": [ { "id": "1168", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1168" } ] }, { "disease_id": "DOID:13810", "recommended_name": { "id": "DOID:13810", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13810", "name": "familial hypercholesterolemia", "description": "A familial hyperlipidemia characterized by very high levels of low-density lipoprotein (LDL) and early cardiovascular disease." }, "synonyms": [ { "id": "DOID:13810", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13810", "name": "Fredrickson type IIa hyperlipoproteinemia", "description": "" }, { "id": "DOID:13810", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13810", "name": "Fredrickson type IIa lipidaemia", "description": "" }, { "id": "DOID:13810", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13810", "name": "familial hyperbetalipoproteinaemia", "description": "" }, { "id": "DOID:13810", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13810", "name": "familial hypercholesteremia", "description": "" }, { "id": "DOID:13810", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13810", "name": "hyperbetalipoproteinemia", "description": "" }, { "id": "DOID:13810", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13810", "name": "type II hyperlipidemia", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "hypercholesterolemia, familial, 1", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "FHCL1", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "LDL cholesterol level QTL2", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "LDL receptor disorder", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "hypercholesterolemia, familial", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "hypercholesterolemia, familial, 1", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "hypercholesterolemia, familial, due to ldlr defect, modifier of", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "hypercholesterolemia, familial, modifier of", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "hypercholesterolemic xanthomatosis, familial", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "hyperlipoproteinemia, type 2", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "hyperlipoproteinemia, type 2A", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "FHC", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "hyper-low-density-lipoproteinemia", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "hypercholesterolemia, susceptibility to", "description": "" }, { "id": "MONDO:0007750", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007750", "name": "low density lipoprotein cholesterol level quantitative trait locus 2", "description": "" }, { "id": "MIM:143890", "resource": "MIM", "url": "https://www.omim.org/entry/143890", "name": "Hypercholesterolemia, familial, 1", "description": "Hypercholesterolemia, familial, 1" } ], "unlinked_id_list": [], "evidence": [ { "id": "13810", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13810" } ] }, { "disease_id": "DOID:1386", "recommended_name": { "id": "DOID:1386", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1386", "name": "abetalipoproteinemia", "description": "A hypolipoproteinemia that is characterized by an inability to fully absorb dietary fats, cholesterol and fat-soluble vitamins, has_material_basis_in an autosomal recessive disorder of lipid metabolism that has_material_basis_in mutation in the microsomal triglyceride transfer protein that catalyzes the transport of lipids and is required in the secretion of BETA-LIPOPROTEINS." }, "synonyms": [ { "id": "DOID:1386", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1386", "name": "microsomal triglyceride transfer protein deficiency disease", "description": "" }, { "id": "DOID:1386", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1386", "name": "familial hypobetalipoproteinemia", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "abetalipoproteinemia", "description": "Abetalipoproteinemia/ homozygous familial hypobetalipoproteinemia (ABL/HoFHBL) is a severe form of familial hypobetalipoproteinemia characterized by permanently low levels (below the 5th percentile) of apolipoprotein B and LDL cholesterol, and by growth delay, malabsorption, hepatomegaly, and neurological and neuromuscular manifestations." }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "Bassen-Kornzweig disease", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "abetalipoproteinemia", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "familial hypobetalipoproteinemia", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "homozygous familial hypobetalipoproteinemia", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "microsomal triglyceride transfer protein deficiency disease", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "ABL", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "Bassen Kornzweig syndrome", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "Bassen-Kornzweig syndrome", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "Betalipoprotein deficiency disease", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "MTP deficiency", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "abetalipoproteinemia neuropathy", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "acanthocytosis", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "apolipoprotein B deficiency", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "congenital betalipoprotein deficiency syndrome", "description": "" }, { "id": "MONDO:0008692", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008692", "name": "microsomal triglyceride transfer Protein deficiency", "description": "" }, { "id": "MIM:200100", "resource": "MIM", "url": "https://www.omim.org/entry/200100", "name": "Abetalipoproteinemia", "description": "Abetalipoproteinemia" } ], "unlinked_id_list": [], "evidence": [ { "id": "1386", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1386" } ] }, { "disease_id": "DOID:2018", "recommended_name": { "id": "DOID:2018", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2018", "name": "hyperinsulinism", "description": "" }, "synonyms": [ { "id": "DOID:2018", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2018", "name": "hyperinsulinemia", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "2018", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2018" } ] }, { "disease_id": "DOID:9452", "recommended_name": { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "steatotic liver disease", "description": "A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in at least 5% of hepatocytes." }, "synonyms": [ { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "Fatty change of liver", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "Steatosis of liver", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "alcoholic fatty liver", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "hepatic lipidosis", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "SLD", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "fatty liver disease", "description": "" }, { "id": "DOID:9452", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9452", "name": "hepatic steatosis", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "visceral steatosis, congenital", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "visceral steatosis, congenital", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "White liver disease", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "fatal neonatal hepatic steatosis", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "fatty liver disease, congenital", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "fatty metamorphosis of viscera", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "steatosis of liver", "description": "" }, { "id": "MONDO:0009220", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009220", "name": "visceral steatosis", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "9452", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9452" } ] }, { "disease_id": "DOID:9970", "recommended_name": { "id": "DOID:9970", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "synonyms": [ { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "inherited obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity (disease)", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "leanness, inherited, autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "monogenic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, association with, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, early-onset, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, late-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, mild, early-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, and type II diabetes, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MIM:601665", "resource": "MIM", "url": "https://www.omim.org/entry/601665", "name": "Obesity", "description": "Obesity" } ], "unlinked_id_list": [], "evidence": [ { "id": "9970", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "mttp", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-040419-2", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040419-2", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IVV0", "url": "https://alphafold.ebi.ac.uk/entry/A0A0R4IVV0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSDARG00000008637", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000008637", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "406207", "url": "https://www.ncbi.nlm.nih.gov/gene/406207", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001747", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001747", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015819", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015819", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039988", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039988", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:406207", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:406207", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HVWGGSA", "url": "https://omabrowser.org/oma/group/HVWGGSA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IVV0", "url": "https://www.orthodb.org/?gene=A0A0R4IVV0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13024", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13024", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13024:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13024:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01347", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19444", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19444", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A0R4IVV0", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:PR_A0A0R4IVV0", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DRE-8964041", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-8964041", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_998135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998135", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "38571", "url": "https://www.rhea-db.org/rhea/38571", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "38895", "url": "https://www.rhea-db.org/rhea/38895", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "39007", "url": "https://www.rhea-db.org/rhea/39007", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "39011", "url": "https://www.rhea-db.org/rhea/39011", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IVV0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-040419-2", "url": "https://zfin.org/ZDB-GENE-040419-2", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MMPVAGLLLCVTAVLCTSALGAGPRLDNGKLYRYSYSTEVGLNRPTGSPGGNVGFRISSDVDINLAWRNPEIQDEQLLQVKISNIQVESAGKHSRKNNIFHGSSAESILGKVRLEALQRPFLVLWKMGKIRSLYAQKAEPATVKNLKRGVASMLMMQLKSGKMSEADASGKCLVEYKVNKHQVIRTKHLETCKSQETGFTTHSPVLGISGKCAAETVITLENGIIKSADAKETHVLSINARHKAATKVLSRQSLTLKAIEAGPAEVAGKDVAGVVKALDDKFLSVGVIVEKTKPKCKGCPNLMETWKAVRSQLEPNSLSKAEAPRSFLTLVHSLRKSSKSEILTVLQNCSKTALPQLVDAVTSAQTPSSLSAILEFLDFSKKDGLILQERFLYACGFASHPTESMLQSLLEVSQGKIGSTEIKESVVIIMGALLRKLCLKGACDLPAVLKVKELLLAGPDSTQEESEVQMYLLALKNALLPEGIPVLAKYAESEVGAYSTIAITALQRYDPALITAEVKKALNRIYHQNQRIYEKNVRAAAADVIMSSNPSYMEVKNLLLSIGHLPHEMNKYMLSKIQDVLRFQMPAYKLVRQVMKDMISHNYDRFSKTGSSSAYSGFMAETVDVTCTYNLDILYSGSGVLRRSNMNIYGQSNNALLHGLQVTIEAQGLESLIAATPDEGEEELESFAGMSALLFDVQLRPVTFFKGYSDLMSKMFSMSGDPINVVKGLILLTDHSQVIPLQSGLRASAEFQAGLSIDISGGMEFSLWYRESKTSVNNRGALVIIGNMTVDTDFVSAGVEVGFETEATLDFITTVQFSEYPFLVCMQMDKTTFPFRETVSKQEKLPTGQMFSRKRSRDQVVPGSEFPLHQENSNMCKKVFEPAW", "length": 884, "header": "sp|A0A0R4IVV0-1|MTP_DANRE Isoform 1 of Microsomal triglyceride transfer protein large subunit OS=Danio rerio OX=7955 GN=mttp PE=1 SV=1 CANONICAL=A0A0R4IVV0-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IVV0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0/entry#A0A0R4IVV0-1", "sequence": { "sequence": "MMPVAGLLLCVTAVLCTSALGAGPRLDNGKLYRYSYSTEVGLNRPTGSPGGNVGFRISSDVDINLAWRNPEIQDEQLLQVKISNIQVESAGKHSRKNNIFHGSSAESILGKVRLEALQRPFLVLWKMGKIRSLYAQKAEPATVKNLKRGVASMLMMQLKSGKMSEADASGKCLVEYKVNKHQVIRTKHLETCKSQETGFTTHSPVLGISGKCAAETVITLENGIIKSADAKETHVLSINARHKAATKVLSRQSLTLKAIEAGPAEVAGKDVAGVVKALDDKFLSVGVIVEKTKPKCKGCPNLMETWKAVRSQLEPNSLSKAEAPRSFLTLVHSLRKSSKSEILTVLQNCSKTALPQLVDAVTSAQTPSSLSAILEFLDFSKKDGLILQERFLYACGFASHPTESMLQSLLEVSQGKIGSTEIKESVVIIMGALLRKLCLKGACDLPAVLKVKELLLAGPDSTQEESEVQMYLLALKNALLPEGIPVLAKYAESEVGAYSTIAITALQRYDPALITAEVKKALNRIYHQNQRIYEKNVRAAAADVIMSSNPSYMEVKNLLLSIGHLPHEMNKYMLSKIQDVLRFQMPAYKLVRQVMKDMISHNYDRFSKTGSSSAYSGFMAETVDVTCTYNLDILYSGSGVLRRSNMNIYGQSNNALLHGLQVTIEAQGLESLIAATPDEGEEELESFAGMSALLFDVQLRPVTFFKGYSDLMSKMFSMSGDPINVVKGLILLTDHSQVIPLQSGLRASAEFQAGLSIDISGGMEFSLWYRESKTSVNNRGALVIIGNMTVDTDFVSAGVEVGFETEATLDFITTVQFSEYPFLVCMQMDKTTFPFRETVSKQEKLPTGQMFSRKRSRDQVVPGSEFPLHQENSNMCKKVFEPAW", "length": 884, "header": "sp|A0A0R4IVV0-1|MTP_DANRE Isoform 1 of Microsomal triglyceride transfer protein large subunit OS=Danio rerio OX=7955 GN=mttp PE=1 SV=1 CANONICAL=A0A0R4IVV0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 348, "start_aa": "Asn", "end_pos": 348, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn348", "evidence": [ { "id": "A0A0R4IVV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0#ptm_processing" }, { "id": "PRU00498", "database": "", "url": "" } ], "filter_code": "00100000000000000000.00010000000000.0.xxxxx" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 787, "start_aa": "Asn", "end_pos": 787, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn787", "evidence": [ { "id": "A0A0R4IVV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.xxxxx" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Developmental expression and nutritional regulation of a zebrafish gene homologous to mammalian microsomal triglyceride transfer protein large subunit.", "journal": "Dev. Dyn.", "date": "2005", "authors": "Marza Esther, Barthe Christophe, Andr\u00e9 Mich\u00e8le, Villeneuve Laure, H\u00e9lou Chantal, Babin Patrick J", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" }, { "database": "RefSeq", "id": "NP_998135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998135" } ], "reference": [ { "type": "PubMed", "id": "15614773", "url": "https://glygen.org/publication/PubMed/15614773" } ] }, { "title": "Microsomal triglyceride transfer protein is required for yolk lipid utilization and absorption of dietary lipids in zebrafish larvae.", "journal": "Biochemistry", "date": "2006-12-26", "authors": "Schlegel Amnon, Stainier Didier Y R", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" }, { "database": "RefSeq", "id": "NP_998135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998135" } ], "reference": [ { "type": "PubMed", "id": "17176039", "url": "https://glygen.org/publication/PubMed/17176039" } ] }, { "title": "Acquisition of triacylglycerol transfer activity by microsomal triglyceride transfer protein during evolution.", "journal": "Biochemistry", "date": "2007-10-30", "authors": "Rava Paul, Hussain M Mahmood", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "reference": [ { "type": "PubMed", "id": "17924655", "url": "https://glygen.org/publication/PubMed/17924655" } ] }, { "title": "ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1.", "journal": "Nature medicine", "date": "2012-06", "authors": "Avraham-Davidi Inbal, Ely Yona, Pham Van N, Castranova Daniel, Grunspan Moshe, Malkinson Guy, Gibbs-Bar Liron, Mayseless Oded, Allmog Gabriella, Lo Brigid, Warren Carmen M, Chen Tom T, Ungos Josette, Kidd Kameha, Shaw Kenna, Rogachev Ilana, Wan Wuzhou, Murphy Philip M, Farber Steven A, Carmel Liran, Shelness Gregory S, Iruela-Arispe M Luisa, Weinstein Brant M, Yaniv Karina", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "reference": [ { "type": "PubMed", "id": "22581286", "url": "https://glygen.org/publication/PubMed/22581286" } ] }, { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] } ], "pathway": [ { "id": "dre:406207", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:406207", "resource": "KEGG Pathway" }, { "id": "R-DRE-8964041", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-8964041", "resource": "Reactome", "description": "LDL remodeling" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A1W8-1", "protein_name": "Microsomal triglyceride transfer protein large subunit", "gene_name": "Mttp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFLDGGKGKLQDSVGYRISSDVDVVLLWRNPDGDDDQLIQVTITAVNVENAGQQRGEKSIFKGKSTPKIVGKDNLEALRRPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQLTSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSGFTTANQVLGVTSKATSVTTYKIEDSFVTAVVAEETRAFALNFLQTVAGKIVSKQKLELKTTEAGPRMVPGKQVAGVIKAIDSKYKAIPIVGQVLQSVCKGCPSLAEHWQSIRKHLEPENLSNAEAVQSFLAFIQHLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPASLEAILDFLDFKSDSSIILQERFLYACGFASHPDEELLQALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAVVEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPVSHLATTVLQRYDASFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNNPSYMDVKNILLSIGELPKEMNKYMLTIVQDILHFEMPASKMIRRVLKEMIVHNYDRFSKSGSSSAYTGYVERSPHAASTYSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDIQLQSGLKANMDIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDITVDSSFVKAGLESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTGRGYVSRRRKESLVPGCELPLHQENSEMCNVVFPPQPESGNSGGGWF", "length": 896 }, "evidence": [ { "id": "MGI:106926", "url": "https://alliancegenome.org/gene/MGI:106926#orthology", "database": "AGR" }, { "id": "HGNC:7467", "url": "https://alliancegenome.org/gene/HGNC:7467#orthology", "database": "AGR" }, { "id": "RGD:1308388", "url": "https://alliancegenome.org/gene/RGD:1308388#orthology", "database": "AGR" }, { "id": "FB:FBgn0266369", "url": "https://alliancegenome.org/gene/FB:FBgn0266369#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040419-2", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040419-2#orthology", "database": "AGR" }, { "id": "A0A0R4IVV0", "url": "https://omabrowser.org/oma/group/A0A0R4IVV0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1MDA1-1", "protein_name": "Microsomal triglyceride transfer protein large subunit", "gene_name": "MTTP", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVFLDRGKGNLQDSVGYRISSNVDVALLWRSPDGDDNQLIQITMKDVNLENVNQQRGEKSIFKGKKSSQIIRKENLEAMQRPVLLHLIHGKIKEFYSYQNEPAAIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAHQDKVTKIKALDSCKIERAGFTTPHQVLGVTSKATSVTTYKIEDSFVVAVLSEEIRALRLNFLQSIAGKIVSRQKLELKTTEASVRLKPGKQVAAIIKAVDSKYTAIPIVGQVFQSKCKGCPSLSEHWQSIRKHLQPDNLSKAEAVRSFLAFIKHLRTAKKEEILQILKAENKEVLPQLVDAVTSAQTPDSLDAILDFLDFKSTESVILQERFLYACAFASHPDEELLRALISKFKGSFGSNDIRESVMIIIGALVRKLCQNQGCKLKGVIEAKKLILGGLEKAEKKEDIVMYLLALKNARLPEGIPLLLKYTETGEGPISHLAATTLQRYDVPFITDEVKKTMNRIYHQNRKIHEKTVRTTAAAIILKNNPSYMEVKNILLSIGELPKEMNKYMLSIVQDILRFETPASKMVRQVLKEMVAHNYDRFSKSGSSSAYTGYVERTSHSASTYSLDILYSGSGILRRSNLNIFQYIEKTPLHGIQVVIEAQGLEALIAATPDEGEENLDSYAGLSALLFDVQLRPVTFFNGYSDLMSKMLSASSDPMSVVKGLLLLIDHSQELQLQSGLKANMDVQGGLAIDITGAMEFSLWYRESKTRVKNRVSVLITGGITVDSSFVKAGLEIGAETEAGLEFISTVQFSQYPFLVCLQMDKEDVPYRQFETKYERLSTGRGYISRKRKESLIGGCEFPLHQENSDMCKVVFAPQPESSSSGWF", "length": 894 }, "evidence": [ { "id": "A0A0R4IVV0", "url": "https://omabrowser.org/oma/group/A0A0R4IVV0/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "F1S0Z3-1", "protein_name": "Microsomal triglyceride transfer protein large subunit", "gene_name": "MTTP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLKYSTEVFLDRGKGNLQDSVGYQISSNVDVVLLWRSPDGDDDQLIQITIKDVKVENVNQQRGEKSIFKGKKPPQIIRKENLEALQRPVLLHLIHGKVKEFYSYQNEPPAIQNLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAHQDKVTKIKALDSCTIERSGFTTRNQVLGVTSKATSVTTYKIEDSFVVAVLAEEIHALRLNFLQTIAGKIVSKQKLELKTTEAGPRLKSGKQVAAIIKAVDSKYTAIPIVGQVFQSECKGCSSLSQHWQSVRKHLQPDNLSKTEAVRSFLTFIQHLRTAKKEEILQILKAENKDILPQLVDAVTSAQTPDSLDAILDFLDFKSDSNIILQERFLYACGFASHPDEELLRALISKFKGSFGSNDIRESVMIIIGALVRKLCQNEGCKLKAVVDAKKLILGGLERAEKKEDTMMYLLALKNARLPEGIPLLLKYAEAAEGPISHLAVTTLQRYDAPFITDEVKKTMNRIYHQTRKVHEKTVRTTAAAVILNNNPSYMEVKNILLSIGELPKEMNKYMLSIVQDILRFEMPASKMVRRVLKEMVAHNYDRFSKSGSSSAYTGYIERGPHSASTYSLDILYSGSGILRRSNLNIFQYVGKTPLHAIQVVIEAQGLEALIAATPDEGEENLDSYAGLSPLLFDVQLRPVTFFNGYSDLMSKMLSASSDPISVVKGLILLIDHSQELQLQSGLKANMEVQGGLAIDISGSMEFSLWYRESKTRVKNRVTVVITGDITVDSSFVKAGLEISAETEAGLEFISTVQFSQYPFLVCLQMDRDGIPYRQLETKYERLSTGRGYVSRKRKEILVAGSEFPLHQENSEMCKVVFAPEPESSSSGWF", "length": 894 }, "evidence": [ { "id": "A0A0R4IVV0", "url": "https://omabrowser.org/oma/group/A0A0R4IVV0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M9QWS9-1", "protein_name": "Microsomal triglyceride transfer protein", "gene_name": "MTTP", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MIVLTVLFLCIISTYSASVKGHTTGPSLSNDRLYRFAYTAEVYVDRAKASLQKSAGYRFSAGVDVNLLWRNPENDDDQLIKVMIRNVQVENVNERPSDKSIFKGKSTEKIIGKEYLEALQRPMVLELARGKVQNFYSYENEPGFTQNLKRGLASLFQLQMHSGSVREVDISGKCNVTYQVRQDQVTKIKALDTCEIEKTGFTSHNQILDVNTKATSATIYVLEDSFIKSIKAEENYVFLLNSRRKTGAKIVSKQKLELQSVEAGPGLIAGKHVAGVIKTLDSSYVSMPLVAETVKSECKKCPSLSEHWKSIKEHMHPEKLSKAEAARSFLSFIQNIRKATKEEILQIIKTENKELLPQIVDAITSAQTPASLEAILEFLDFKDASTSVLQERFLYACGFASHPSEMLLRSLTSKFKGDIANEEIRETLVIVMGELIRKLCDREGCKLPAVVEAKKLILGRLEKPKKDDNVRMYLLALKNALLPEAIPLLLKYAESDEGHISNAAVTALQRYDPSFLTNEVKKTMNRIYHQNRKVHEKTVRTTAAAIILNSNPSYMEVKNILLSIGELPLEMNKYMLSIIQDILQLEKPSSKTVRKVLKDMRAHNYERFSKPGSSSAYSGYITRGPDISSTYGLDILYSGSGILRRSNLNIHVFDRNAQLHAGQVVIEAQGLESIIAATPDEGEENLDSFAGMSAILFDVQLRPVTFFQGYGDLMSKMLSATGDPISVVKGLILLTDYSQEFQLQSGPRASADFQGGLAIDISGGMEFSLWYRESKTNVKNRIAMFVAGNAEVDSFFLKTGMETTLEIETALDFISTVQFSQYPFLVCMQMDRVGSPFRHSVTKYESLPSGRRYTARRGKAEMLEGCEYPLHQENSNMCRKVFSTASDSSGSWF", "length": 893 }, "evidence": [ { "id": "A0A0R4IVV0", "url": "https://omabrowser.org/oma/group/A0A0R4IVV0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O08601-1", "protein_name": "Microsomal triglyceride transfer protein large subunit", "gene_name": "Mttp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFLDGGKGKPQDSVGYKISSDVDVVLLWRNPDGDDDQVIQVTITAVNVENAGQQRGEKSIFQGKSTPKIIGKDNLEALQRPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSGFTTANQVLGVSSKATSVTTYKIEDSFVTAVLAEETRAFALNFQQTIAGKIVSKQKLELKTTEAGPRMIPGKQVAGVIKAVDSKYKAIPIVGQVLERVCKGCPSLAEHWKSIRKNLEPENLSKAEAVQSFLAFIQHLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPDSLEAILDFLDFKSDSSIILQERFLYACGFATHPDEELLRALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAVVEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPVSHLATTVLQRYDVSFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNPSYMDVKNILLSIGELPKEMNKYMLTVVQDILHFEMPASKMIRRVLKEMAVHNYDRFSKSGSSSAYTGYVERSPRAASTYSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDIQLQSGLKANMEIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDVTVDASFVKAGVESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTGRGYVSRRRKESLVAGCELPLHQENSEMCNVVFPPQPESDNSGGWF", "length": 894 }, "evidence": [ { "id": "MGI:106926", "url": "https://alliancegenome.org/gene/MGI:106926#orthology", "database": "AGR" }, { "id": "HGNC:7467", "url": "https://alliancegenome.org/gene/HGNC:7467#orthology", "database": "AGR" }, { "id": "RGD:1308388", "url": "https://alliancegenome.org/gene/RGD:1308388#orthology", "database": "AGR" }, { "id": "FB:FBgn0266369", "url": "https://alliancegenome.org/gene/FB:FBgn0266369#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040419-2", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040419-2#orthology", "database": "AGR" }, { "id": "A0A0R4IVV0", "url": "https://omabrowser.org/oma/group/A0A0R4IVV0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P55157-1", "protein_name": "Microsomal triglyceride transfer protein large subunit", "gene_name": "MTTP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF", "length": 894 }, "evidence": [ { "id": "MGI:106926", "url": "https://alliancegenome.org/gene/MGI:106926#orthology", "database": "AGR" }, { "id": "HGNC:7467", "url": "https://alliancegenome.org/gene/HGNC:7467#orthology", "database": "AGR" }, { "id": "RGD:1308388", "url": "https://alliancegenome.org/gene/RGD:1308388#orthology", "database": "AGR" }, { "id": "FB:FBgn0266369", "url": "https://alliancegenome.org/gene/FB:FBgn0266369#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040419-2", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040419-2#orthology", "database": "AGR" }, { "id": "A0A0R4IVV0", "url": "https://omabrowser.org/oma/group/A0A0R4IVV0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VIH3-1", "protein_name": "Microsomal triacylglycerol transfer protein", "gene_name": "Mtp", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MENKNKKCLRTLLLLALFLGLLEDGKTALIAPNSQQIFKLQNQVILQELGRDSSSAETSYTFETDLKINSVWSGDEDQLLEVFISGSKVDASGKARSITRIPDRPFYISLVRGQPDKVIAHTSKDQSLLNLERGIASLLQLRLDASQEEELDVSGLCRVSYNVKSSTKVEKTKRDCSLWDLRVNYNPEEALGVTQQAQETVFYELSSEGTLLHAESQENHRLNLAAKPDVGSFVKSSLILQHVSQGSEEVKQLQLGSLDKAIQSLLEWYRVFELESDVDGMISAIKEQTLEDQLKASLTELQSADVGKSSLALAYVKLIPLARITRQEQFEDLLTEHAEVLPQLVDLLGAVQTFDAHNATFGFLYKESETTSEQLDLLEKYLQSLAVATHPDRKIVEHLFGLLEQESIKKHLKLRESVIQTVATLTRQSGLDVEDPLLKEVRSYLLQGLTSKEPTLYIRALQNLQDPATIEALLEHAQTGEAPNLSVAALQALKAFPLGSFNSSHRLQFESIFYQRKRRFDSSARTLALDIILSLRPTQEQLGNFLDYLASNDRQFEIKTYVLQKLRMLAEKCPRFRALFKSELVKRRHVNNYNVLGQKGLTTVLTRQLSQAPAFNETLLSTQEVYQGILKRGSVEFLLHAGRSQASSFKLGIYTAGLGSLVGDGDSGDGNDAIPADDEFSEDEAVTAGMEISVQGAQLRPLVFFSGQTELMGHVWGGSASDSTPAYQATTLSQDNEHYIILTSGATLHWRVLGARSVDLNGKVGFSLWNRNAQTEIQQNTGSAVLGHLAVGFTYAKLVQDFSITHEPKLSLNADLDFYSGIKLCMQLQRPEQLLKQTNVRSVFLQSVDRPYAKHVRSTLSHKTAGCTFALNQKNNEMCNLIFRDL", "length": 886 }, "evidence": [ { "id": "MGI:106926", "url": "https://alliancegenome.org/gene/MGI:106926#orthology", "database": "AGR" }, { "id": "HGNC:7467", "url": "https://alliancegenome.org/gene/HGNC:7467#orthology", "database": "AGR" }, { "id": "RGD:1308388", "url": "https://alliancegenome.org/gene/RGD:1308388#orthology", "database": "AGR" }, { "id": "FB:FBgn0266369", "url": "https://alliancegenome.org/gene/FB:FBgn0266369#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040419-2", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040419-2#orthology", "database": "AGR" }, { "id": "A0A0R4IVV0", "url": "https://omabrowser.org/oma/group/A0A0R4IVV0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "lipid transporter activity", "id": "GO:0005319", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005319", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "phospholipid transporter activity", "id": "GO:0005548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005548", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "phosphatidylethanolamine transfer activity", "id": "GO:1904121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904121", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "lipid transfer activity", "id": "GO:0120013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120013", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "lipoprotein metabolic process", "id": "GO:0042157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042157", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "lipoprotein biosynthetic process", "id": "GO:0042158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042158", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "lipoprotein transport", "id": "GO:0042953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042953", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "cholesterol homeostasis", "id": "GO:0042632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042632", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "digestion", "id": "GO:0007586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007586", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "sprouting angiogenesis", "id": "GO:0002040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002040", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "protein secretion", "id": "GO:0009306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009306", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "long-chain fatty acid transport", "id": "GO:0015909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015909", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "plasma lipoprotein particle assembly", "id": "GO:0034377", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034377", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" }, { "name": "medium-chain fatty acid transport", "id": "GO:0001579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001579", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IVV0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IVV0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 787, "end_pos": 789, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "38571", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "38571", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38571" } ] }, { "id": "38895", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "38895", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38895" } ] }, { "id": "39007", "name": "", "equation": "a cholesterol ester(in) = a cholesterol ester(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "39007", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39007" } ] }, { "id": "39011", "name": "", "equation": "a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "39011", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39011" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.agr", "label": "AGR Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 348, 787 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 348, "end_pos": 350 }, { "start_pos": 787, "end_pos": 789 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { 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